eosinophil cationic protein

Summary

Gene Symbol: eosinophil cationic protein
Description: ribonuclease A family member 3
Alias: ECP, RAF1, RNS3, eosinophil cationic protein, RNase 3, cytotoxic ribonuclease, ribonuclease 3, ribonuclease, RNase A family, 3
Species: human
Products:     eosinophil cationic protein

Top Publications

  1. Hamann K, Ten R, Loegering D, Jenkins R, Heise M, Schad C, et al. Structure and chromosome localization of the human eosinophil-derived neurotoxin and eosinophil cationic protein genes: evidence for intronless coding sequences in the ribonuclease gene superfamily. Genomics. 1990;7:535-46 pubmed
    Human genomic DNAs for the eosinophil granule proteins, eosinophil-derived neurotoxin (EDN) and eosinophil cationic protein (ECP), were isolated from genomic libraries...
  2. Gleich G, Loegering D, Bell M, Checkel J, Ackerman S, McKean D. Biochemical and functional similarities between human eosinophil-derived neurotoxin and eosinophil cationic protein: homology with ribonuclease. Proc Natl Acad Sci U S A. 1986;83:3146-50 pubmed
    Eosinophil-derived neurotoxin (EDN) and eosinophil cationic protein (ECP) were isolated from lysates of human eosinophil granules by gel filtration and ion exchange chromatography on heparin-Sepharose...
  3. Noguchi E, Iwama A, Takeda K, Takeda T, Kamioka M, Ichikawa K, et al. The promoter polymorphism in the eosinophil cationic protein gene and its influence on the serum eosinophil cationic protein level. Am J Respir Crit Care Med. 2003;167:180-4 pubmed
    Asthma is characterized by reversible airway obstruction and airway inflammation. Serum levels of eosinophil cationic protein (ECP) might reflect eosinophilic airway inflammation and asthma activity...
  4. Kim Y, Kumaraswami V, Choi E, Mu J, Follmann D, Zimmerman P, et al. Genetic polymorphisms of eosinophil-derived neurotoxin and eosinophil cationic protein in tropical pulmonary eosinophilia. Am J Trop Med Hyg. 2005;73:125-30 pubmed
    Because eosinophil-derived neurotoxin (EDN) and eosinophil cationic protein (ECP) are critical in the pathogenesis of tropical pulmonary eosinophilia (TPE), we analyzed genetic polymorphisms of both in 181 individuals from southern India ..
  5. Jönsson U, Bystrom J, Stalenheim G, Venge P. Polymorphism of the eosinophil cationic protein-gene is related to the expression of allergic symptoms. Clin Exp Allergy. 2002;32:1092-5 pubmed
    We have found a polymorphism in the ECP (eosinophil cationic protein)-gene at position 434 according to GenBank accession number NM 002935...
  6. Carreras E, Boix E, Navarro S, Rosenberg H, Cuchillo C, Nogués M. Surface-exposed amino acids of eosinophil cationic protein play a critical role in the inhibition of mammalian cell proliferation. Mol Cell Biochem. 2005;272:1-7 pubmed
    b>Eosinophil cationic protein (ECP) is a ribonuclease secreted from activated eosinophils that may cause tissue injure as a result of eosinophilic inflammation...
  7. Fan T, Chang H, Chen I, Wang H, Chang M. A heparan sulfate-facilitated and raft-dependent macropinocytosis of eosinophil cationic protein. Traffic. 2007;8:1778-95 pubmed
    b>Eosinophil cationic protein (ECP), a human RNAseA superfamily member, highly implicated in asthma pathology, is toxic to bronchial epithelial cells following its endocytosis...
  8. Torrent M, Navarro S, Moussaoui M, Nogués M, Boix E. Eosinophil cationic protein high-affinity binding to bacteria-wall lipopolysaccharides and peptidoglycans. Biochemistry. 2008;47:3544-55 pubmed publisher
    The eosinophil cationic protein (ECP) is an eosinophil-secreted RNase involved in the immune host defense, with a cytotoxic activity against a wide range of pathogens...
  9. Torrent M, de la Torre B, Nogués V, Andreu D, Boix E. Bactericidal and membrane disruption activities of the eosinophil cationic protein are largely retained in an N-terminal fragment. Biochem J. 2009;421:425-34 pubmed publisher
    ECP (eosinophil cationic protein) is an eosinophil secretion protein with antipathogen activities involved in the host immune defence system...

More Information

Publications105 found, 100 shown here

  1. Niccoli G, Ferrante G, Cosentino N, Conte M, Belloni F, Marino M, et al. Eosinophil cationic protein: A new biomarker of coronary atherosclerosis. Atherosclerosis. 2010;211:606-11 pubmed publisher
    ..We aimed at assessing the role of eosinophil cationic protein (ECP), a sensitive marker of eosinophil activation, and C-reactive protein (CRP) in coronary artery ..
  2. Gabay J, Scott R, Campanelli D, Griffith J, Wilde C, Marra M, et al. Antibiotic proteins of human polymorphonuclear leukocytes. Proc Natl Acad Sci U S A. 1989;86:5610-4 pubmed
    ..The other, named azurocidin, was abundant and comparable to bactericidal permeability-increasing factor in its contribution to the killing of Escherichia coli. ..
  3. Boix E, Nikolovski Z, Moiseyev G, Rosenberg H, Cuchillo C, Nogués M. Kinetic and product distribution analysis of human eosinophil cationic protein indicates a subsite arrangement that favors exonuclease-type activity. J Biol Chem. 1999;274:15605-14 pubmed
    With the use of a high yield prokaryotic expression system, large amounts of human eosinophil cationic protein (ECP) have been obtained. This has allowed a thorough kinetic study of the ribonuclease activity of this protein...
  4. Boix E, Leonidas D, Nikolovski Z, Nogués M, Cuchillo C, Acharya K. Crystal structure of eosinophil cationic protein at 2.4 A resolution. Biochemistry. 1999;38:16794-801 pubmed
    b>Eosinophil cationic protein (ECP) is located in the matrix of the eosinophil's large specific granule and has marked toxicity for a variety of helminth parasites, hemoflagellates, bacteria, single-stranded RNA virus, and mammalian cells ..
  5. Trulson A, Bystrom J, Engstrom A, Larsson R, Venge P. The functional heterogeneity of eosinophil cationic protein is determined by a gene polymorphism and post-translational modifications. Clin Exp Allergy. 2007;37:208-18 pubmed
    ..and takes part in parasite killing and tissue-destructive processes by secretion of proteins such as eosinophil cationic protein (ECP)...
  6. Munthe Kaas M, Gerritsen J, Carlsen K, Undlien D, Egeland T, Skinningsrud B, et al. Eosinophil cationic protein (ECP) polymorphisms and association with asthma, s-ECP levels and related phenotypes. Allergy. 2007;62:429-36 pubmed
    b>Eosinophil cationic protein (ECP) is a potent cytotoxic secretory protein with bactericidal and antiviral properties. ECP is released by activated eosinophils and regarded as a marker of eosinophilic inflammation...
  7. Navarro S, Aleu J, Jimenez M, Boix E, Cuchillo C, Nogués M. The cytotoxicity of eosinophil cationic protein/ribonuclease 3 on eukaryotic cell lines takes place through its aggregation on the cell membrane. Cell Mol Life Sci. 2008;65:324-37 pubmed
    Human eosinophil cationic protein (ECP)/ ribonuclease 3 (RNase 3) is a protein secreted from the secondary granules of activated eosinophils...
  8. Torrent M, Sanchez D, Buzon V, Nogués M, Cladera J, Boix E. Comparison of the membrane interaction mechanism of two antimicrobial RNases: RNase 3/ECP and RNase 7. Biochim Biophys Acta. 2009;1788:1116-25 pubmed publisher
    b>Eosinophil cationic protein (ECP/RNase 3) and the skin derived ribonuclease 7 (RNase 7) are members of the RNase A superfamily. RNase 3 is mainly expressed in eosinophils whereas RNase 7 is primarily secreted by keratinocytes...
  9. Eriksson J, Reimert C, Kabatereine N, Kazibwe F, Ireri E, Kadzo H, et al. The 434(G>C) polymorphism within the coding sequence of Eosinophil Cationic Protein (ECP) correlates with the natural course of Schistosoma mansoni infection. Int J Parasitol. 2007;37:1359-66 pubmed
    ..b>Eosinophil cationic protein (ECP) is a secretory protein of eosinophil granulocytes that efficiently kills the larval stage of S...
  10. Fan T, Fang S, Hwang C, Hsu C, Lu X, Hung S, et al. Characterization of molecular interactions between eosinophil cationic protein and heparin. J Biol Chem. 2008;283:25468-74 pubmed publisher
    b>Eosinophil cationic protein (ECP) is currently used as a biomarker for airway inflammation. It is a heparin-binding ribonuclease released by activated eosinophils. Its cytotoxicity toward cancer cell lines is blocked by heparin...
  11. Rubin J, Zagai U, Blom K, Trulson A, Engström Å, Venge P. The coding ECP 434(G>C) gene polymorphism determines the cytotoxicity of ECP but has minor effects on fibroblast-mediated gel contraction and no effect on RNase activity. J Immunol. 2009;183:445-51 pubmed publisher
    b>Eosinophil cationic protein (ECP) is a secretory protein of the eosinophil granulocyte, a cell involved in innate immunity...
  12. Kang I, An X, Oh Y, Lee S, Jung H, Chae S, et al. Identification of polymorphisms in the RNase3 gene and the association with allergic rhinitis. Eur Arch Otorhinolaryngol. 2010;267:391-5 pubmed publisher
    b>Eosinophil cationic protein (ECP), a potent cytotoxic molecule, is released by activated eosinophils. ECP has been suggested to be involved in tissue remodeling of allergic diseases...
  13. Zhang J, Rosenberg H. Sequence variation at two eosinophil-associated ribonuclease loci in humans. Genetics. 2000;156:1949-58 pubmed
    ..sequences of 2417 nucleotides at the two EAR loci, the eosinophil-derived neurotoxin (EDN, RNase 2) and eosinophil cationic protein (ECP, RNase 3), from >50 human individuals. Our data demonstrate that the nucleotide diversities (0...
  14. Jönsson U, Håkansson L, Jogi R, Janson C, Venge P. Associations of ECP (eosinophil cationic protein)-gene polymorphisms to allergy, asthma, smoke habits and lung function in two Estonian and Swedish sub cohorts of the ECRHS II study. BMC Pulm Med. 2010;10:36 pubmed publisher
    The Eosinophil Cationic Protein (ECP) is a potent multifunctional protein. Three common polymorphisms are present in the ECP gene, which determine the function and production of the protein...
  15. Carlson M, Venge P, Lampinen M. C3b-induced eosinophil degranulation involves PI3-kinases and is inhibited by protein kinase C activity. APMIS. 2011;119:119-26 pubmed publisher
    ..The aim of this study was to investigate if selective release of eosinophil cationic protein (ECP), eosinophil protein X/eosinophil derived-neurotoxin (EPX/EDN) and eosinophil peroxidase (EPO) ..
  16. Hassel B, de Souza G, Stensland M, Ivanovic J, Voie Ø, Dahlberg D. The proteome of pus from human brain abscesses: host-derived neurotoxic proteins and the cell-type diversity of CNS pus. J Neurosurg. 2017;:1-9 pubmed publisher
    ..Some of the identified proteins have well-known neurotoxic effects, e.g., eosinophil cationic protein and nonsecretory ribonuclease (also known as eosinophil-derived neurotoxin)...
  17. Rajamanickam A, Munisankar S, Bhootra Y, Dolla C, Nutman T, Babu S. Elevated Systemic Levels of Eosinophil, Neutrophil, and Mast Cell Granular Proteins in Strongyloides Stercoralis Infection that Diminish following Treatment. Front Immunol. 2018;9:207 pubmed publisher
    ..To this end, we measured the plasma levels of eosinophil cationic protein, eosinophil-derived neurotoxin, eosinophil peroxidase, eosinophil major basic protein, neutrophil ..
  18. Li Z, Long Y, Bai M, Li J, Feng Z. Neutrophil and Eosinophil Granule Proteins as Potential Biomarkers of Assessing Disease Activity and Severity in Patients With Ulcerative Colitis. J Clin Lab Anal. 2016;30:776-8 pubmed publisher
    ..In this study, we assessed fecal eosinophil cationic protein (FECP), fecal myeloperoxidase (FMPO), and fecal calprotectin (FC) as surrogate markers of disease ..
  19. Kim M, Yoo J, Kim J, Park J, Han E, Jang W, et al. Association of FLG single nucleotide variations with clinical phenotypes of atopic dermatitis. PLoS ONE. 2017;12:e0190077 pubmed publisher
    ..Serologic parameters such as serum eosinophil cationic protein (ECP) and eosinophil derived neurotoxin (EDN) were measured...
  20. Moideen K, Kumar N, Nair D, Banurekha V, Bethunaickan R, Babu S. Heightened Systemic Levels of Neutrophil and Eosinophil Granular Proteins in Pulmonary Tuberculosis and Reversal following Treatment. Infect Immun. 2018;86: pubmed publisher
    ..neutrophil elastase, proteinase 3, major basic protein (MBP), eosinophil-derived neurotoxin (EDN), eosinophil cationic protein (ECP), and eosinophil peroxidase (EPX) in these individuals...
  21. Pham D, Ban G, Kim S, Shin Y, Ye Y, Chwae Y, et al. Neutrophil autophagy and extracellular DNA traps contribute to airway inflammation in severe asthma. Clin Exp Allergy. 2017;47:57-70 pubmed publisher
    ..production; the effects of NETs on PBEs were examined by investigating the activation and release of eosinophil cationic protein (ECP) and eosinophil-derived neurotoxin (EDN)...
  22. Wright B, Ochkur S, Olson N, Shim K, Jacobsen E, Rank M, et al. Normalized serum eosinophil peroxidase levels are inversely correlated with esophageal eosinophilia in eosinophilic esophagitis. Dis Esophagus. 2017;: pubmed publisher
    ..195 cells/?L, P = 0.008). Absolute median serum eosinophil peroxidase, eosinophil cationic protein, and eosinophil derived neurotoxin did not differ between groups; however, when normalized for absolute ..
  23. Kanazawa H, Yoshida N, Iino Y. New Insights into Eosinophilic Otitis Media. Curr Allergy Asthma Rep. 2015;15:76 pubmed publisher
    ..effusion containing eosinophils and immunoglobulin E (IgE), eosinophil chemoattractants, such as eosinophil cationic protein, interleukin-5, and eotaxin. Local sensitization against foreign agents such as fungi or bacteria (e.g...
  24. Mokra D, Drgova A, Mokry J, Antosova M, Durdik P, Calkovska A. N-acetylcysteine effectively diminished meconium-induced oxidative stress in adult rabbits. J Physiol Pharmacol. 2015;66:101-10 pubmed
    ..To evaluate participation of eosinophils in the meconium-induced inflammation, eosinophil cationic protein (ECP) was detected in plasma and lung homogenate...
  25. Shute J, Calzetta L, Cardaci V, di Toro S, Page C, Cazzola M. Inhaled nebulised unfractionated heparin improves lung function in moderate to very severe COPD: A pilot study. Pulm Pharmacol Ther. 2018;48:88-96 pubmed publisher
    ..that the basic proteins lactoferrin, platelet factor-4 (PF-4), IL-8 and polyarginine, as a model of the eosinophil cationic protein (ECP), found in COPD sputum neutralise the anticoagulant activity of heparin...
  26. Adu B, Dodoo D, Adukpo S, Gyan B, Hedley P, Goka B, et al. Polymorphisms in the RNASE3 gene are associated with susceptibility to cerebral malaria in Ghanaian children. PLoS ONE. 2011;6:e29465 pubmed publisher
    ..falciparum induces eosinophilia and found a significantly higher serum level of eosinophil cationic protein (ECP) in CM patients than in uncomplicated malaria (UM) and severe malaria anemia (SA) patients...
  27. Castro N, Neves P, Cestaro J, Melo V, Schneider A, Pfeifer L. Use of prostaglandin F2? as ovulatory stimulus for synchronizing dairy cattle. Res Vet Sci. 2018;118:151-154 pubmed publisher
    ..three groups to receive: 1) 2mL of Saline (Control Group, n=25), 2) 150?g of PGF (PGF Group, n=25) or 3) 1mg of ECP (ECP Group, n=23). Diameter of ovulatory follicle was larger in the PGF and Control than ECP Group (P=0...
  28. Hohlfeld J, Schmiedl A, Erpenbeck V, Venge P, Krug N. Eosinophil cationic protein alters pulmonary surfactant structure and function in asthma. J Allergy Clin Immunol. 2004;113:496-502 pubmed
    ..which, on activation, release inflammatory mediators, especially reactive granula proteins such as eosinophil cationic protein (ECP)...
  29. Boix E, Pulido D, Moussaoui M, Nogués M, Russi S. The sulfate-binding site structure of the human eosinophil cationic protein as revealed by a new crystal form. J Struct Biol. 2012;179:1-9 pubmed publisher
    The human eosinophil cationic protein (ECP), also known as RNase 3, is an eosinophil secretion protein that is involved in innate immunity and displays antipathogen and proinflammatory activities...
  30. Lien P, Kuo P, Chen C, Chang H, Fang S, Wu W, et al. In silico prediction and in vitro characterization of multifunctional human RNase3. Biomed Res Int. 2013;2013:170398 pubmed publisher
    ..In this study, we provide novel insights to identify functional regions of hRNase3 that may have implications for all hRNaseA superfamily members. ..
  31. Fichter A, Ritschl L, Borgmann A, Humbs M, Luppa P, Wolff K, et al. Development of an Extracorporeal Perfusion Device for Small Animal Free Flaps. PLoS ONE. 2016;11:e0147755 pubmed publisher
    Extracorporeal perfusion (ECP) might prolong the vital storage capabilities of composite free flaps, potentially opening a wide range of clinical applications...
  32. de Oliveira P, de Oliveira Lopes D, do Vale Coelho I, Pereira M. Cytotoxic Activities of Eosinophil Cationic Protein and Eosinophil-derived Neurotoxin: In Silico Analysis. Cancer Genomics Proteomics. 2015;12:397-402 pubmed
    b>Eosinophil cationic protein (ECP) and eosinophil derived-neurotoxin (EDN) are homologous ribonuclease (RNAse) A family proteins...
  33. Hähnel V, Dormann F, Nitsopoulos A, Friedle A, Ahrens N. A method for the quantification of 8-methoxypsoralen by mass spectrometry for offline extracorporeal photopheresis. Photochem Photobiol Sci. 2017;16:193-200 pubmed publisher
    Extracorporeal photopheresis (ECP) is an efficient method to treat various autoimmune diseases, cutaneous T-cell lymphoma, and graft-versus-host disease...
  34. Del Fante C, Perotti C. Extracorporeal photopheresis for bronchiolitis obliterans syndrome after allogeneic stem cell transplant: An emerging therapeutic approach?. Transfus Apher Sci. 2017;56:17-19 pubmed publisher
    ..In this scenario, extracorporeal photopheresis (ECP) bursts as a new immunomodulatory approach with a different philosophical purpose...
  35. Hsu C, Chang C, Liao Y, Wu S, Chen C. Solution structure and base specificity of cytotoxic RC-RNase 2 from Rana catesbeiana. Arch Biochem Biophys. 2015;584:70-8 pubmed publisher
    ..RC-RNase 2, a cytotoxic ribonuclease isolated from oocytes of bullfrog Rana catesbeiana, consists of 105 residues linked with 4 disulfide ..
  36. Ezzouhairi S. [Evaluation of the efficacy of diode laser endocyclophotocoagulation combined with cataract surgery in glaucoma]. J Fr Ophtalmol. 2015;38:844-54 pubmed publisher
    ..in the surgical management of glaucoma; the diode laser coupled to an endoscope, endocyclophotocoagulation (ECP), is an emerging technology in the treatment of glaucoma...
  37. Lind L, Siegbahn A, Lindahl B, Stenemo M, Sundström J, Ärnlöv J. Discovery of New Risk Markers for Ischemic Stroke Using a Novel Targeted Proteomics Chip. Stroke. 2015;46:3340-7 pubmed publisher
    ..Of these, N-terminal pro-B-type natriuretic peptide (P=0.0032), adrenomedullin (P=0.018), and eosinophil cationic protein (P=0.0071) were replicated in ULSAM after adjustment for established stroke risk factors...
  38. Saising J, Nguyen M, Härtner T, Ebner P, Al Mamun Bhuyan A, Berscheid A, et al. Rhodomyrtone (Rom) is a membrane-active compound. Biochim Biophys Acta Biomembr. 2018;1860:1114-1124 pubmed publisher
    ..potential within seconds and at low doses, causes release of ATP and even the excretion of cytoplasmic proteins (ECP), but does not induce pore-formation as for example nisin...
  39. Rea C, Tran K, Jorina M, Wenren L, Hawryluk E, Toomey S. A Randomized Controlled Trial of an Eczema Care Plan. Acad Pediatr. 2018;18:789-796 pubmed publisher
    To test whether an eczema care plan (ECP) would improve provider documentation and management, decrease eczema severity, and increase patient quality of life (QOL) in the pediatric primary care setting...
  40. de Waure C, Capri S, Veneziano M, Specchia M, Cadeddu C, Di Nardo F, et al. Extracorporeal Photopheresis for Second-Line Treatment of Chronic Graft-versus-Host Diseases: Results from a Health Technology Assessment in Italy. Value Health. 2015;18:457-66 pubmed publisher
    ..a comparative, cost-effectiveness, and budget impact analysis of Therakos online extracorporeal photopheresis (ECP) compared with the main alternatives used for the treatment of steroid-refractory/resistant chronic graft-versus-..
  41. Liu C, Schindler E, Leroy M, Martin Bredahl K, Dino M, Shah K, et al. Safety and collection efficiency with a lower transfusion threshold for extracorporeal photopheresis in adult patients with graft-versus-host disease. Vox Sang. 2017;112:379-387 pubmed publisher
    Extracorporeal photopheresis (ECP) is an established treatment for graft-versus-host disease (GVHD). Various haematocrit thresholds have been used to trigger red blood cells transfusion prior to ECP...
  42. Pecoraro Y, Carillo C, Diso D, Mantovani S, Cimino G, De Giacomo T, et al. Efficacy of Extracorporeal Photopheresis in Patients With Bronchiolitis Obliterans Syndrome After Lung Transplantation. Transplant Proc. 2017;49:695-698 pubmed publisher
    ..Extracorporeal photopheresis (ECP) seems to reduce the rate of lung function decline in transplant recipients with progressive BOS...
  43. Bennett M, Melton C, Annaberdiyev A, Wang G, Shulenburger L, Mitas L. A new generation of effective core potentials for correlated calculations. J Chem Phys. 2017;147:224106 pubmed publisher
    ..The key improvements include consistent use of correlated methods throughout ECP constructions and improved transferability as required for an accurate description of molecular systems over a ..
  44. Lodin K, Lekander M, Syk J, Alving K, Andréasson A. Associations between self-rated health, sickness behaviour and inflammatory markers in primary care patients with allergic asthma: a longitudinal study. NPJ Prim Care Respir Med. 2017;27:67 pubmed publisher
    ..disorder associated with elevated levels of immunoglobulin E (IgE), serum eosinophilic cationic protein (S-ECP), plasma eosinophil-derived neurotoxin (P-EDN) and fraction of exhaled nitric oxide (FENO)...
  45. Elmose C, Sverrild A, van der Sluis S, Kyvik K, Backer V, Thomsen S. Genetic factors explain half of all variance in serum eosinophil cationic protein. Clin Exp Allergy. 2014;44:1525-30 pubmed publisher
    b>Eosinophil cationic protein (ECP) is one of four basic proteins of the secretory granules of eosinophils. It has a variety of functions associated with inflammatory responses...
  46. Sakkal S, Miller S, Apostolopoulos V, Nurgali K. Eosinophils in Cancer: Favourable or Unfavourable?. Curr Med Chem. 2016;23:650-66 pubmed
    ..Eosinophils secrete a variety of cytokines and factors including eosinophil cationic protein, eosinophil-derived neurotoxin, peroxidase and major basic protein which have either anti-tumor effects ..
  47. Jaudszus A, Mainz J, Pittag S, Dornaus S, Dopfer C, Roth A, et al. Effects of a dietary intervention with conjugated linoleic acid on immunological and metabolic parameters in children and adolescents with allergic asthma--a placebo-controlled pilot trial. Lipids Health Dis. 2016;15:21 pubmed publisher
    ..specific IgE, in vitro allergen-induced cytokine production in peripheral blood mononuclear cells (PBMC), plasma ECP, urinary 8-oxodG as marker of oxidation, fatty acid profiles of erythrocytes, and routine haematological parameters ..
  48. Mahmood A, Longo R. Structural and relative energy assessments of DFT functionals and the MP2 method to describe the gas phase methylation of nitronates: [R(1)R(2)CNO2](-) + CH3I. Phys Chem Chem Phys. 2016;18:17062-70 pubmed publisher
    ..The basis sets involved an effective core potential (ECP) for describing the inner electrons of iodine such as LANL2DZdp and aug-cc-pVXZ-PP (X = D, T, and Q), and all-..
  49. Uslenghi G, Vater A, Rodríguez Aguilar S, Cabodevila J, Callejas S. Effect of estradiol cypionate and GnRH treatment on plasma estradiol-17? concentrations, synchronization of ovulation and on pregnancy rates in suckled beef cows treated with FTAI-based protocols. Reprod Domest Anim. 2016;51:693-9 pubmed publisher
    ..150 mg of D-cloprostenol and were randomly assigned to four treatment groups (n = 10/treatment): Group ECP: 1 mg of estradiol cypionate at PID removal, Group EB: 1 mg of EB 24 hr after PID removal, Group GnRH: 10 ?g of ..
  50. Papageorgiou I, Abberton T, Fuller M, Tipper J, Fisher J, Ingham E. Biological Effects of Clinically Relevant CoCr Nanoparticles in the Dura Mater: An Organ Culture Study. Nanomaterials (Basel). 2014;4:485-504 pubmed publisher
    ..ELISA analysis revealed that there was significant release of cytokines including IL-8, IL-6, TNF-α, ECP and also the matrix protein, tenascin-C...
  51. de Lima Bezerra Cavalcanti H, Bruno Rocha G. Spin states of Mn(III) meso-tetraphenylporphyrin chloride assessed by density functional methods. J Mol Model. 2017;23:363 pubmed publisher
    ..GGA, meta-GGA and hybrid functionals), in combination with a variety of basis sets and effective core potentials (ECP) for their ability to predict the ground spin state of Mn(III) meso-tetraphenylporphyrin chloride complex, labeled ..
  52. HetmaÅ„czyk J, HetmaÅ„czyk Å, MigdaÅ‚ Mikuli A, Mikuli E. Vibrations and reorientations of NH3 molecules in [Mn(NH3)6](ClO4)2 studied by infrared spectroscopy and theoretical (DFT) calculations. Spectrochim Acta A Mol Biomol Spectrosc. 2015;136 Pt C:1515-22 pubmed publisher
    ..by comparison with respective theoretical spectra calculated using DFT method (B3LYP functional, LANL2DZ ECP basis set (on Mn atom) and 6-311+G(d,p) basis set (on H, N, Cl, O atoms) for the isolated equilibrium two models (..
  53. Niccoli G, Calvieri C, Minelli S, Copponi G, Montone R, Montone R, et al. Permanent polymer of drug eluting stents increases eosinophil cationic protein levels following percutaneous coronary intervention independently of C-reactive protein. Atherosclerosis. 2014;237:816-20 pubmed publisher
    To assess eosinophil cationic protein (ECP) and C-reactive protein (CRP) serum levels at three time points according to different stent types...
  54. Liu R, Chen H, Zhang R, Zhou Z, Hou Z, Gao D, et al. Comparative Transcriptome Analysis of Vibrio splendidus JZ6 Reveals the Mechanism of Its Pathogenicity at Low Temperatures. Appl Environ Microbiol. 2016;82:2050-2061 pubmed publisher
    ..factor (extracellular metalloprotease) was also found to be highly expressed in the extracellular product (ECP) of JZ6 at 10°C, and this ECP exhibited obvious cytotoxicity to oyster primary hemocytes, A549 cells, and L929 ..
  55. Gorka K, Soja J, Jakieła B, Plutecka H, Gross Sondej I, Cmiel A, et al. Relationship between the thickness of bronchial wall layers, emphysema score, and markers of remodeling in bronchoalveolar lavage fluid in patients with chronic obstructive pulmonary disease. Pol Arch Med Wewn. 2016;126:402-10 pubmed publisher
    ..1, transforming growth factor ?1 [TGF-?1]) and inflammatory markers (neutrophil elastase, eosinophil cationic protein) were measured in BALF samples using an enzyme-linked immunosorbent assay...
  56. Chieregato K, Alghisi A, Borghero C, Elice F, Raimondi R, Zanetti E, et al. Evaluation of lymphocytes inactivation by extracorporeal photopheresis using tetrazolium salt based-assay. Transfus Apher Sci. 2015;53:242-5 pubmed publisher
    Extracorporeal photopheresis (ECP) is accepted as a second-line therapy for the treatment of acute and chronic steroid-refractory graft versus host disease (GvHD), cutaneous T-cell lymphoma and solid organ transplantation...
  57. Medina A, Mancera J, Martínez Manzanares E, Moriñigo M, Arijo S. Identification of Vibrio harveyi proteins involved in the specific immune response of Senegalese sole (Solea senegalensis, Kaup). Fish Shellfish Immunol. 2015;47:377-80 pubmed publisher
    ..harveyi bacterin supplemented with inactivated extracellular polymeric substances (ECP) and Freund incomplete adjuvant to obtain polyclonal antiserum...
  58. Hollander D, Pennesi M, Alvarado J. Management of plateau iris syndrome with cataract extraction and endoscopic cyclophotocoagulation. Exp Eye Res. 2017;158:190-194 pubmed publisher
    ..biomicroscopy (UBM) following iridotomy, underwent cataract extraction and endoscopic cyclophotocoagulation (ECP). The ciliary body was treated for a median of 180° (range of 120-360°)...
  59. Sundström J, Söderholm M, Borné Y, Nilsson J, Persson M, Östling G, et al. Eosinophil Cationic Protein, Carotid Plaque, and Incidence of Stroke. Stroke. 2017;48:2686-2692 pubmed publisher
    ECP (eosinophil cationic protein) is a marker of eosinophil activity and degranulation, which has been linked to atherosclerosis and cardiovascular disease...
  60. Nikolovski Z, Buzon V, Ribo M, Moussaoui M, Vilanova M, Cuchillo C, et al. Thermal unfolding of eosinophil cationic protein/ribonuclease 3: a nonreversible process. Protein Sci. 2006;15:2816-27 pubmed
    b>Eosinophil cationic protein (ECP)/ribonuclease 3 is a member of the RNase A superfamily involved in inflammatory processes mediated by eosinophils...
  61. Silva A, Levy L, Trindade J, Mendonça P, Silva C, Lopes A. Faecal and serum levels of eosinophil cationic protein in a healthy paediatric population. Scand J Clin Lab Invest. 2007;67:757-66 pubmed
    b>Eosinophil cationic protein (ECP) has been regarded as an excellent marker of eosinophil activation in various diseases where eosinophil-mediated inflammation plays a role...
  62. Behnecke A, Mayr S, Schick B, Iro H, Raithel M. Evaluation of ECP release from intact tissue biopsies from patients with nasal polyps. Inflamm Res. 2008;57 Suppl 1:S65-6 pubmed publisher
  63. Tas D, Ozer H, Erken E. Serum eosinophil cationic protein levels in Behçet's disease and its relation to clinical activity. Asian Pac J Allergy Immunol. 2013;31:67-72 pubmed
    b>Eosinophil cationic protein (ECP) is a matrix protein of eosinophils and has been reported to reflect eosinophil activity. Few studies have examined the role of eosinophils in the pathogenesis of Behçet's disease...
  64. Trautinger F. Phototherapy of mycosis fungoides. G Ital Dermatol Venereol. 2017;152:597-606 pubmed publisher
    ..Patients with erythroderma and blood involvement benefit from treatment with extracorporeal photochemotherapy (ECP) where peripheral blood is exposed to PUVA...
  65. de Oliveira P, de Lima P, Oliveira D, Pereira M. Eosinophil cationic protein: overview of biological and genetic features. DNA Cell Biol. 2012;31:1442-6 pubmed publisher
    The eosinophil cationic protein (ECP) is a small polypeptide that originates from activated eosinophil granulocytes. A wide range of stimuli has been shown to induce the secretion of ECP...
  66. Xia G, Wang Y, Huang Z. The Correlation of Serum Myeloid-Related Protein-8/14 and Eosinophil Cationic Protein in Patients with Coronary Artery Disease. Biomed Res Int. 2016;2016:4980251 pubmed publisher
    To investigate the changes in serum Myeloid-Related Protein 8/14 (MRP8/14) and Eosinophil Cationic Protein (ECP) levels in patients with different types of coronary artery diseases (CAD) and assess the value of MRP8/14 and ECP detection ..
  67. Siotto M, Aprile I, Simonelli I, Pazzaglia C, Ventriglia M, Santoro M, et al. An exploratory study of BDNF and oxidative stress marker alterations in subacute and chronic stroke patients affected by neuropathic pain. J Neural Transm (Vienna). 2017;124:1557-1566 pubmed publisher
    ..metal status were evaluated: copper, iron, transferrin, ferritin, ceruloplasmin concentration (iCp) and activity (eCp), Total Antioxidant status (TAS), Cp/Tf ratio, eCp/iCp ratio, and non-ceruloplasmin bound copper (Non-Cp Cu)...
  68. Rosenberg H, Ackerman S, Tenen D. Human eosinophil cationic protein. Molecular cloning of a cytotoxin and helminthotoxin with ribonuclease activity. J Exp Med. 1989;170:163-76 pubmed
    We have isolated a 725-bp full-length cDNA clone for the human eosinophil cationic protein (ECP)...
  69. Savignano C, Rinaldi C, Tursi V, Dolfini C, Isola M, Livi U, et al. Extracorporeal photochemotherapy in heart transplant rejection: A single-center experience. Transfus Apher Sci. 2017;56:520-524 pubmed publisher
    The addition of extracorporeal photochemotherapy (ECP) to standard immunosuppressive therapy has been suggested to be beneficial in the treatment of recurrent/persistent heart rejection...
  70. Takeno S, Yoshimura H, Kubota K, Taruya T, Ishino T, Hirakawa K. Comparison of Nasal Nitric Oxide Levels between the Inferior Turbinate Surface the Middle Meatus in Patients with Symptomatic Allergic Rhinitis. Allergol Int. 2014;63:475-483 pubmed publisher
    ..The analysis of nasal brushing cells revealed significantly higher eosinophil cationic protein and nitrotyrosine levels in the AR groups...
  71. Yerrabothala S, Talebian L, Klinker K, Hickman J, Hill J, Hayes C, et al. Extracorporeal photopheresis for graft versus host disease: Identifying a clinical pathway and associated resource utilization. J Clin Apher. 2017;: pubmed publisher
    Extracorporeal photopheresis (ECP) is an established therapy for the treatment of graft-versus-host-disease (GVHD) following an allogeneic stem cell transplant...
  72. Darvishi Cheshmeh Soltani R, Mashayekhi M. Decomposition of ibuprofen in water via an electrochemical process with nano-sized carbon black-coated carbon cloth as oxygen-permeable cathode integrated with ultrasound. Chemosphere. 2018;194:471-480 pubmed publisher
    ..IBP)-polluted aquatic phase using a novel oxygen-permeable cathode (OPC)-equipped electrochemical process (ECP) integrated with ultrasound (US)...
  73. Davidsson A, Schmekel B. Histamine release from blood cells and serum ECP in patients with asthma, during and after a mild pollen season. Inflamm Res. 2005;54 Suppl 1:S76-7 pubmed
  74. Monteseirín J, Vega A, Chacón P, Camacho M, El Bekay R, Asturias J, et al. Neutrophils as a novel source of eosinophil cationic protein in IgE-mediated processes. J Immunol. 2007;179:2634-41 pubmed
    The production of eosinophil cationic protein (ECP) in IgE-mediated diseases has been associated mainly with eosinophils, although no IgE-dependent ECP release has been observed in these cells...
  75. Peona V, De Amici M, Quaglini S, Bellaviti G, Castellazzi A, Marseglia G, et al. Serum eosinophilic cationic protein: is there a role in respiratory disorders?. J Asthma. 2010;47:131-4 pubmed publisher
    Eosinophilic cationic protein (ECP) has been widely investigated in the clinical practice as a potential biomarker for asthma. However, there are conflicting data concerning its validity in other respiratory disorders...
  76. Niccoli G, Sgueglia G, Conte M, Cosentino N, Minelli S, Belloni F, et al. Eosinophil cationic protein and clinical outcome after bare metal stent implantation. Atherosclerosis. 2011;215:166-9 pubmed publisher
    we assessed the association between baseline eosinophil cationic protein (ECP) levels, a sensitive marker of eosinophil activation, and clinical outcome in patients undergoing bare metal stent (BMS) implantation...
  77. Pulido D, Moussaoui M, Nogués M, Torrent M, Boix E. Towards the rational design of antimicrobial proteins: single point mutations can switch on bactericidal and agglutinating activities on the RNase A superfamily lineage. FEBS J. 2013;280:5841-52 pubmed publisher
    ..In an effort to identify the minimal requirements for the eosinophil cationic protein (ECP or RNase 3) antimicrobial properties we applied site-directed mutagenesis on its closest family ..
  78. Wang H, Chang H, Pai T, Wu C, Lee Y, Chang Y, et al. Transcriptional regulation of human eosinophil RNases by an evolutionary- conserved sequence motif in primate genome. BMC Mol Biol. 2007;8:89 pubmed
    Human eosinophil-derived neurotoxin (edn) and eosinophil cationic protein (ecp) are members of a subfamily of primate ribonuclease (rnase) genes...
  79. Choi G, Kim J, Shin Y, Ye Y, Kim S, Park H. Eosinophil activation and novel mediators in the aspirin-induced nasal response in AERD. Clin Exp Allergy. 2013;43:730-40 pubmed publisher
    ..b>Eosinophil cationic protein (ECP) and cysteinyl leucotriene (CysLT) levels were measured using an ImmunoCAP system and ELISA ..
  80. Ribeiro C, Martins M, Bressiani A, Bressiani J, Leyva M, de Queiroz A. Electrochemical preparation and characterization of PNIPAM-HAp scaffolds for bone tissue engineering. Mater Sci Eng C Mater Biol Appl. 2017;81:156-166 pubmed publisher
    ..The electrochemical polymerization (ECP) of acrylic monomers has received an increased attention in recent years due to its versatility in the production ..
  81. Miranda W, Oh J. Effusive-Constrictive Pericarditis. Cardiol Clin. 2017;35:551-558 pubmed publisher
    Effusive-constrictive pericarditis (ECP) corresponds to the coexistence of a hemodynamically significant pericardial effusion and decreased pericardial compliance...
  82. Pérez Bartolomé F, Rodrigues I, Goyal S, Bloch E, S Lim W, Alaghband P, et al. Phacoemulsification plus endoscopic cyclophotocoagulation versus phacoemulsification alone in primary open-angle glaucoma. Eur J Ophthalmol. 2017;: pubmed publisher
    To examine the efficacy and safety of combined phacoemulsification and endoscopic cyclophotocoagulation (phaco-ECP) compared to phacoemulsification alone in patients with primary open-angle glaucoma (POAG).
  83. Schneiderman J. Extracorporeal photopheresis: cellular therapy for the treatment of acute and chronic graft-versus-host disease. Hematology Am Soc Hematol Educ Program. 2017;2017:639-644 pubmed publisher
    ..Extracorporeal photopheresis (ECP) is a widely used cellular therapy currently approved by the US Food and Drug Administration for use in patients ..
  84. Dall Amico R, Montini G, Murer L, Andreetta B, Zacchello G, Gambino A, et al. Extracorporeal photochemotherapy after cardiac transplantation: a new therapeutic approach to allograft rejection. Int J Artif Organs. 2000;23:49-54 pubmed
    Photopheresis (ECP) is a new immunomodulatory therapy in which recipient lymphocytes are treated extracorporeally with 8-methoxypsoralen and ultraviolet light...
  85. Tian J, Lu H, Liu Y, Sun C, Xue H, Meng W, et al. [The measuring of ECP and IgE in middle ear effusion of patients with otitis media of effusion]. Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2006;20:449-50, 453 pubmed
    To study the relationship between otitis media of effusion (OME) and allergy by investigating eosinophil cationic protein in middle ear effusion ( MECP), middle ear effusion IgE (MIgE) and serum eosinophil cationic protein (SECP)...
  86. Woschnagg C, Rubin J, Venge P. Eosinophil cationic protein (ECP) is processed during secretion. J Immunol. 2009;183:3949-54 pubmed publisher
    ..b>Eosinophil cationic protein (ECP) is a basic and potentially cytotoxic granule protein that is released from the eosinophil upon ..
  87. Boumendjel A, Tridon A, Messarah M, Ughetto S, Meharzi S, Boulakoud M. Eosinophilic activity and bronchial hyperresponsiveness within an asthmatic paediatric population. Allergol Immunopathol (Madr). 2012;40:301-5 pubmed publisher
    Our study aims to assess the importance of serum eosinophil cationic protein (ECP) levels as a non-invasive marker of bronchial hyperresponsiveness (BHR) in children with asthma, and may predict objectively the asthmatic severity and ..
  88. Mastrianni D, Eddy R, Rosenberg H, Corrette S, Shows T, Tenen D, et al. Localization of the human eosinophil Charcot-Leyden crystal protein (lysophospholipase) gene (CLC) to chromosome 19 and the human ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2 and RNS3) to. Genomics. 1992;13:240-2 pubmed
  89. Mallorquí Fernández G, Pous J, Peracaula R, Aymami J, Maeda T, Tada H, et al. Three-dimensional crystal structure of human eosinophil cationic protein (RNase 3) at 1.75 A resolution. J Mol Biol. 2000;300:1297-307 pubmed
    b>Eosinophil cationic protein (ECP; RNase 3) is a human ribonuclease found only in eosinophil leukocytes that belongs to the RNase A superfamily. This enzyme is bactericidal, helminthotoxic and cytotoxic to mammalian cells and tissues...
  90. Jung J, Kang H, Lee H, Park H, Cho S, Min K, et al. Expression levels of eosinophil granule protein mRNAs in induced sputum reflect airway hyperresponsiveness and airflow limitation. Tohoku J Exp Med. 2014;233:49-56 pubmed
    ..extracellular release of a number of eosinophil granule proteins, including major basic protein (MBP), eosinophil cationic protein (ECP), eosinophil peroxidase (EPO), and eosinophil-derived neurotoxin...
  91. Shigesato M, Elia J, Tschann M, Bullock H, Hurwitz E, Wu Y, et al. Pharmacy access to Ulipristal acetate in major cities throughout the United States. Contraception. 2018;97:264-269 pubmed publisher
    Ulipristal acetate (UPA) is a prescription emergency contraceptive pill (ECP)...
  92. Boix E, Carreras E, Nikolovski Z, Cuchillo C, Nogués M. Identification and characterization of human eosinophil cationic protein by an epitope-specific antibody. J Leukoc Biol. 2001;69:1027-35 pubmed
    The eosinophil cationic protein (ECP) is a basic secretion protein involved in the immune response system...