Gene Symbol: env
Species: Human T-lymphotropic virus 1
Malik K, Even J, Karpas A. Molecular cloning and complete nucleotide sequence of an adult T cell leukaemia virus/human T cell leukaemia virus type I (ATLV/HTLV-I) isolate of Caribbean origin: relationship to other members of the ATLV/HTLV-I subgroup. J Gen Virol. 1988;69 ( Pt 7):1695-710 pubmed publisher
..Analysis of defective proviral clones isolated from the same genomic library is also reported, and suggests a pattern of proviral sequence deletions during the biogenesis of defective proviruses...
Capdepont S, Londos Gagliardi D, Joubert M, Correze P, Lafon M, Guillemain B, et al
. New insights in HTLV-I phylogeny by sequencing and analyzing the entire envelope gene. AIDS Res Hum Retroviruses. 2005;21:28-42 pubmed
..It is thus important to study the genetic variability of the viral env gene as well as its variation in terms of evolution...
Manel N, Battini J, Sitbon M. Human T cell leukemia virus envelope binding and virus entry are mediated by distinct domains of the glucose transporter GLUT1. J Biol Chem. 2005;280:29025-9 pubmed publisher
..Therefore, binding involves a discrete determinant in the carboxyl terminal ECL6, whereas post-binding events engage extracellular sequences in the amino and carboxyl terminus of GLUT1...
Li K, Zhang S, Kronqvist M, Wallin M, Ekstr m M, Derse D, et al
. Intersubunit disulfide isomerization controls membrane fusion of human T-cell leukemia virus Env. J Virol. 2008;82:7135-43 pubmed publisher
Human T-cell leukemia virus (HTLV-1) Env carries a typical disulfide isomerization motif, C(225)XXC, in the C-terminal domain SU...
Kannian P, Fernandez S, Jones K, Green P. Human T lymphotropic virus type 1 SU residue 195 plays a role in determining the preferential CD4+ T cell immortalization/transformation tropism. J Virol. 2013;87:9344-52 pubmed publisher
..The slower emergence of the CD8(+) T cell predominance in Ach.195-infected cultures suggests that other residues/domains contribute to this tropism preference. ..
Blot V, Delamarre L, Perugi F, Pham D, B nichou S, Benarous R, et al
. Human Dlg protein binds to the envelope glycoproteins of human T-cell leukemia virus type 1 and regulates envelope mediated cell-cell fusion in T lymphocytes. J Cell Sci. 2004;117:3983-93 pubmed publisher
..we identified hDlg as a cellular binding partner of a viral membrane integral protein, the envelope glycoprotein (Env) of human T-cell leukemia virus type 1 (HTLV-1)...
Kiyasu J, Sagara Y, Kohno K, Sato K, Kimura Y, Hashikawa K, et al
. Frequent expression of gp46 in adult T-cell leukemia/lymphoma: an immunohistochemical study of 40 cases. Pathol Int. 2010;60:774-8 pubmed publisher
..0%). These results suggest that gp46-197 immunohistochemical staining can be a useful histological indicator for prediction of the aggressiveness of ATLL and prognosis for ATLL patients. ..
Maeda Y, Terasawa H, Tanaka Y, Mitsuura C, Nakashima K, Yusa K, et al
. Separate cellular localizations of human T-lymphotropic virus 1 (HTLV-1) Env and glucose transporter type 1 (GLUT1) are required for HTLV-1 Env-mediated fusion and infection. J Virol. 2015;89:502-11 pubmed publisher
Interaction of the envelope glycoprotein (Env) of human T-lymphotropic virus 1 (HTLV-1) with the glucose transporter type 1 (GLUT1) expressed in target cells is essential for viral entry...
Wilson K, B r S, Maerz A, Alizon M, Poumbourios P. The conserved glycine-rich segment linking the N-terminal fusion peptide to the coiled coil of human T-cell leukemia virus type 1 transmembrane glycoprotein gp21 is a determinant of membrane fusion function. J Virol. 2005;79:4533-9 pubmed publisher
..Retroviral glycoprotein fusion function thus appears to require flexibility within the glycine-rich segment and hydrophobic contacts mediated by this segment...