eNOS

Summary

Gene Symbol: eNOS
Description: nitric oxide synthase 3
Alias: ECNOS, eNOS, nitric oxide synthase, endothelial, EC-NOS, NOS type III, NOSIII, cNOS, constitutive NOS, endothelial NOS, nitric oxide synthase 3 (endothelial cell), nitric oxide synthase 3 transcript variant eNOS-delta20, nitric oxide synthase 3 transcript variant eNOS-delta20-21, nitric oxide synthase 3 transcript variant eNOS-delta21
Species: human
Products:     eNOS

Top Publications

  1. Casas J, Cavalleri G, Bautista L, Smeeth L, Humphries S, Hingorani A. Endothelial nitric oxide synthase gene polymorphisms and cardiovascular disease: a HuGE review. Am J Epidemiol. 2006;164:921-35 pubmed
    ..The need for large-scale genetic association studies using tagging polymorphisms is warranted to confirm or refute a role of the NOS3 gene in coronary heart disease. ..
  2. Naber C, Baumgart D, Altmann C, Siffert W, Erbel R, Heusch G. eNOS 894T allele and coronary blood flow at rest and during adenosine-induced hyperemia. Am J Physiol Heart Circ Physiol. 2001;281:H1908-12 pubmed
    The 894T allele of a G894T polymorphism in the endothelial nitric oxide synthase (eNOS) gene is associated with decreased eNOS activity, cleavage of the protein, and endothelial dysfunction...
  3. Saini V, Bhatnagar M, Bhattacharjee J. Endothelial nitric oxide synthase Glu298Asp (G894T) gene polymorphism in coronary artery disease patients with type 2 diabetes mellitus. Diabetes Metab Syndr. 2012;6:106-9 pubmed publisher
    ..This study determined the role of endothelial nitric oxide synthase (eNOS) Glu298Asp polymorphism and intergenotypic variation of plasma nitric oxide (NO) levels in coronary artery disease (..
  4. Rahimi Z, Nourozi Rad R, Rahimi Z, Parsian A. Strong interaction between T allele of endothelial nitric oxide synthase with B1 allele of cholesteryl ester transfer protein TaqIB highly elevates the risk of coronary artery disease and type 2 diabetes mellitus. Hum Genomics. 2012;6:20 pubmed publisher
    ..004). Our findings, for the first time, indicate that NOS3 T allele strongly interacts with CETP B1 allele to augment the risk of CAD and T2DM in the population of Western Iran. ..
  5. Bianco B, Ghirelli Filho M, Cavalheiro C, Cavalcanti V, Peluso C, Gava M, et al. Variants in endothelial nitric oxide synthase (eNOS) gene in idiopathic infertile Brazilian men. Gene. 2013;519:13-7 pubmed publisher
    ..The aim of the study was to analyze the distribution of the of endothelial nitric oxide synthase (eNOS) gene (T-786C, G894T, e 4a/b) polymorphisms in idiopathic infertile Brazilian men and evaluate the possible role of ..
  6. Zigra A, Rallidis L, Anastasiou G, Merkouri E, Gialeraki A. eNOS gene variants and the risk of premature myocardial infarction. Dis Markers. 2013;34:431-6 pubmed publisher
    Endothelial nitric oxide synthase (eNOS) as well as nitric oxide play an important role in the regulation of cardiovascular function...
  7. Kanias T, Wang L, Lippert A, Kim Shapiro D, Gladwin M. Red blood cell endothelial nitric oxide synthase does not modulate red blood cell storage hemolysis. Transfusion. 2013;53:981-9 pubmed publisher
    The red blood cell (RBC) endothelial nitric oxide synthase (eNOS) has been shown to regulate intrinsic RBC rheologic properties, such as membrane deformability, suggesting that a functional eNOS could be important in RBC viability and ..
  8. Cheema B, Kohli H, Sharma R, Bhansali A, Khullar M. Endothelial nitric oxide synthase gene polymorphism and type 2 diabetic retinopathy among Asian Indians. Acta Diabetol. 2012;49:481-8 pubmed publisher
    Endothelial nitric oxide synthase (eNOS) has been shown to play an essential role in retinal vascular function, and disequilibrium in its production can lead to diabetic retinopathy (DR)...
  9. Horn P, Cortese Krott M, Amabile N, Hundsdörfer C, Kröncke K, Kelm M, et al. Circulating microparticles carry a functional endothelial nitric oxide synthase that is decreased in patients with endothelial dysfunction. J Am Heart Assoc. 2012;2:e003764 pubmed publisher
    ..and endothelial cells, we hypothesized that MPs may harbor functional enzymes including an endothelial NO synthase (eNOS). Using immunoprecipitation and Western blot analysis, we found that human circulating MPs carry an eNOS...

More Information

Publications295 found, 100 shown here

  1. Ekmekci A, Ozcan K, Gungor B, Abaci N, Osmonov D, Zencirci A, et al. The relationship between endothelial nitric oxide synthase 4a/4b gene polymorphism and premature coronary artery disease. Acta Cardiol. 2013;68:464-8 pubmed
    ..Endothelial nitric oxide synthase (eNOS) intron 4a/b polymorphism has been shown to be related to plasma nitric oxide concentrations and coronary artery ..
  2. Yang Y, Du K, Liu Z, Lu X. Endothelial nitric oxide synthase (eNOS) 4b/a gene polymorphisms and coronary artery disease: evidence from a meta-analysis. Int J Mol Sci. 2014;15:7987-8003 pubmed publisher
    A variety of studies have suggested that the 4b/a polymorphism in the endothelial nitric oxide synthase (eNOS) was associated with coronary artery disease (CAD) risk. However, the data remain conflicting...
  3. Weiss J, Fränkl S, Flammer J, Grieshaber M, Hollo G, Teuchner B, et al. No difference in genotype frequencies of polymorphisms of the nitric oxide pathway between Caucasian normal and high tension glaucoma patients. Mol Vis. 2012;18:2174-81 pubmed
    ..These results therefore suggest the absence of a relevant relationship with different glaucoma forms in Caucasians. ..
  4. Cortese Krott M, Rodriguez Mateos A, Sansone R, Kuhnle G, Thasian Sivarajah S, Krenz T, et al. Human red blood cells at work: identification and visualization of erythrocytic eNOS activity in health and disease. Blood. 2012;120:4229-37 pubmed publisher
    ..ESI-MS/MS-based peptide sequencing and enzymatic assay we further demonstrate that human RBCs contain an endothelial NOS (eNOS) that converts L-(3)H-arginine to L-(3)H-citrulline in a Ca(2+)/calmodulin-dependent fashion...
  5. Arun Kumar A, Umamaheswaran G, Padmapriya R, Balachandar J, Adithan C. Endothelial nitric oxide synthase gene polymorphisms and the risk of acute myocardial infarction in a South Indian population. Mol Biol Rep. 2013;40:1275-81 pubmed publisher
    ..05) but the odds ratio (0.6) did not show risk for MI. The present study showed lack of association between NOS3 gene polymorphisms and MI in South Indian population. ..
  6. Narne P, Ponnaluri K, Singh S, Siraj M, Ishaq M. Association of the genetic variants of endothelial nitric oxide synthase gene with angiographically defined coronary artery disease and myocardial infarction in South Indian patients with type 2 diabetes mellitus. J Diabetes Complications. 2013;27:255-61 pubmed publisher
    The polymorphic variants of endothelial nitric oxide synthase (eNOS) gene have been implicated in endothelial dysfunction and are highly relevant to macroangiopathies...
  7. Abdel Aziz T, Mohamed R. Association of endothelial nitric oxide synthase gene polymorphisms with classical risk factors in development of premature coronary artery disease. Mol Biol Rep. 2013;40:3065-71 pubmed publisher
    Genetic polymorphism of the endothelial nitric oxide synthase (eNOS) affects the pathogenesis of atherosclerosis and associated with premature coronary artery disease (PCAD)...
  8. Demirçubuk A, Coskun M, Demiryurek S, Dokuyucu R, Oztuzcu S, Taviloğlu Z, et al. Endothelial NOS gene Glu298Asp polymorphism in preterm neonates with respiratory distress syndrome. Pediatr Pulmonol. 2013;48:976-80 pubmed publisher
    ..According to few studies in recent years, endothelial nitric oxide synthase (eNOS) gene polymorphisms are found to be partially responsible for liability to RDS...
  9. Tian G, Zeng X, Wang X, Zhang L, Zhang W, Wei W. Association between the endothelial nitric oxide synthase gene Glu298Asp polymorphism and coronary heart disease: a meta?analysis of 39 case?control studies. Mol Med Rep. 2013;7:1310-8 pubmed publisher
    Numerous studies have indicated that the human endothelial nitric oxide synthase (eNOS) gene Glu298Asp polymorphism is associated with coronary heart disease (CHD) susceptibility, however, their conclusions are inconsistent...
  10. Kallel A, Sbaï M, Sediri Y, Abdessalem S, Mourali M, Feki M, et al. Polymorphisms of the NOS3 gene and risk of myocardial infarction in the Tunisian population. Cytokine. 2013;64:646-51 pubmed publisher
    Controversial results regarding the association of eNOS gene (NOS3) polymorphisms with myocardial infarction (MI) have been reported...
  11. Häkli T, Romppanen E, Hiltunen M, Helisalmi S, Punnonen K, Heinonen S. Endothelial nitric oxide synthase polymorphism in preeclampsia. J Soc Gynecol Investig. 2003;10:154-7 pubmed
    We wished to determine whether genetic variability in the gene encoding endothelial nitric oxide synthase (eNOS) modifies individual susceptibility to the development of preeclampsia...
  12. Nagase S, Suzuki H, Wang Y, Kikuchi S, Hirayama A, Ueda A, et al. Association of ecNOS gene polymorphisms with end stage renal diseases. Mol Cell Biochem. 2003;244:113-8 pubmed
    ..Several polymorphisms of the endothelial NO synthase (eNOS) gene have been reported. For instance, tandem 27-bp repeats in intron 4 of the eNOS gene are polymorphic, i.e...
  13. Tai S, Robb G, Marsden P. Endothelial nitric oxide synthase: a new paradigm for gene regulation in the injured blood vessel. Arterioscler Thromb Vasc Biol. 2004;24:405-12 pubmed
    ..molecular mechanisms involved in the constitutive and regulated expression of endothelial nitric oxide synthase (eNOS) mRNA expression present a new level of complexity to the study of endothelial gene regulation in health and ..
  14. Rios D, Callegari Jacques S, Hutz M. Endothelial nitric oxide synthase and fractalkine chemokine receptor polymorphisms on angiographically assessed coronary atherosclerosis. Clin Chim Acta. 2005;362:138-46 pubmed
    ..The endothelial nitric oxide synthase (eNOS) produces nitric oxide that acts on the vascular wall and circulating blood cells, lessening the inflammatory ..
  15. Antoniades C, Tousoulis D, Vasiliadou C, Pitsavos C, Chrysochoou C, Panagiotakos D, et al. Genetic polymorphism on endothelial nitric oxide synthase affects endothelial activation and inflammatory response during the acute phase of myocardial infarction. J Am Coll Cardiol. 2005;46:1101-9 pubmed
    This study sought to evaluate the effect of genetic polymorphism G894T on endothelial nitric oxide synthase (eNOS); on the risk for myocardial infarction (MI); and on the release of von Willebrand factor (vWF), interleukin (IL)-6, IL-1b, ..
  16. Kitsios G, Zintzaras E. An NOS3 Haplotype is Protective against Hypertension in a Caucasian Population. Int J Hypertens. 2010;2010:865031 pubmed publisher
    ..5%) compared to cases (2%). These results indicate that although individual NOS3 polymorphisms are not associated with hypertension, a rare haplotype of the gene might be protective against the development of hypertension. ..
  17. Aras O, Hanson N, Bakanay S, Tsai M, Gulec S. Endothelial nitric oxide gene polymorphism (Glu298Asp) is not associated with coronary artery disease in Turkish population. Thromb Haemost. 2002;87:347-9 pubmed
  18. Nakayama M, Yoshimura M, Sakamoto T, Shimasaki Y, Nakamura S, Ito T, et al. Synergistic interaction of T-786-->C polymorphism in the endothelial nitric oxide synthase gene and smoking for an enhanced risk for coronary spasm. Pharmacogenetics. 2003;13:683-8 pubmed
    ..In the females, ACh-induced vasoconstrictions were significantly greater in Groups B, C and D than in Group A. The T-786-->C polymorphism and smoking combine to increase the risk of coronary spasm. ..
  19. Lin H, Tsai C, Tsai F, Chen W, Tsai S, Fan S. Distribution of oxidation enzyme eNOS and myeloperoxidase in primary open angle glaucoma. J Clin Lab Anal. 2005;19:87-92 pubmed
    ..between primary open angle glaucoma (POAG) and two polymorphisms in the epithelial nitric oxide synthase (eNOS) gene, and one polymorphism in the myeloperoxidase (MPO) gene...
  20. Berger K, Stögbauer F, Stoll M, Wellmann J, Huge A, Cheng S, et al. The glu298asp polymorphism in the nitric oxide synthase 3 gene is associated with the risk of ischemic stroke in two large independent case-control studies. Hum Genet. 2007;121:169-78 pubmed
    ..Using large sample sizes and a replication study approach, we found evidence for a role of a polymorphism in the nitric oxide synthase 3 gene in stroke onset. ..
  21. Saluja R, Jyoti A, Chatterjee M, Habib S, Verma A, Mitra K, et al. Molecular and biochemical characterization of nitric oxide synthase isoforms and their intracellular distribution in human peripheral blood mononuclear cells. Biochim Biophys Acta. 2011;1813:1700-7 pubmed publisher
    ..We observed constitutive expression of full length NOS isoforms (nNOS, iNOS and eNOS) in PBMCs: with the highest expression of iNOS in comparison to nNOS and eNOS...
  22. Colombo M, Paradossi U, Andreassi M, Botto N, Manfredi S, Masetti S, et al. Endothelial nitric oxide synthase gene polymorphisms and risk of coronary artery disease. Clin Chem. 2003;49:389-95 pubmed
    Endothelial nitric oxide synthase (eNOS) could be a candidate gene for coronary artery disease (CAD)...
  23. Dengel D, Brown M, Ferrell R, Reynolds T, Supiano M. A preliminary study on T-786C endothelial nitric oxide synthase gene and renal hemodynamic and blood pressure responses to dietary sodium. Physiol Res. 2007;56:393-401 pubmed
    The purpose of the present study was to examine the role of the T-786C endothelial nitric oxide synthase (eNOS) gene polymorphism on changes in renal hemodynamics and blood pressure due to Na(+) loading...
  24. Thameem F, Puppala S, Arar N, Stern M, Blangero J, Duggirala R, et al. Endothelial nitric oxide synthase (eNOS) gene polymorphisms and their association with type 2 diabetes-related traits in Mexican Americans. Diab Vasc Dis Res. 2008;5:109-13 pubmed publisher
    Genetic variants of the endothelial nitric oxide synthase (eNOS) gene such as T-786C, Glu298Asp and 27bp-VNTR have been examined for their association with type 2 diabetes (T2DM)-related traits in various populations but not in Mexican ..
  25. Lin S, Qu H, Qiu M. Allele A in intron 4 of ecNOS gene will not increase the risk of diabetic nephropathy in type 2 diabetes of Chinese population. Nephron. 2002;91:768 pubmed
  26. Liakopoulos O, Dorge H, Popov A, Schmitto J, Cattaruzza M, Schoendube F. Influence of eNOS gene polymorphisms (894G/T; - 786C/T) on postoperative hemodynamics after cardiac surgery. Thorac Cardiovasc Surg. 2006;54:233-8 pubmed
    ..in vascular reactivity have been associated with variable NO release due to 894G/T and -786C/T polymorphisms of the eNOS gene...
  27. Li J, Wu X, Li X, Feng G, He L, Shi Y. The endothelial nitric oxide synthase gene is associated with coronary artery disease: a meta-analysis. Cardiology. 2010;116:271-8 pubmed publisher
    Previous case-control studies have suggested that the endothelial nitric oxide synthase (eNOS) gene polymorphisms (G894T, 4b/a, T-786C) are associated with coronary artery disease (CAD)...
  28. Chen P, Tsai A, Wu K. Cysteine 99 of endothelial nitric oxide synthase (NOS-III) is critical for tetrahydrobiopterin-dependent NOS-III stability and activity. Biochem Biophys Res Commun. 1995;215:1119-29 pubmed
    ..However, its binding sites and functional roles remain elusive. Here, we demonstrated that cys-99 of human endothelial NOS (ecNOS) is critical for BH4 involvement in NOS catalytic activity and stability...
  29. Chang K, Baek S, Seung K, Kim P, Ihm S, Chae J, et al. The Glu298Asp polymorphism in the endothelial nitric oxide synthase gene is strongly associated with coronary spasm. Coron Artery Dis. 2003;14:293-9 pubmed
    ..We investigated whether the Glu298Asp polymorphism in the endothelial nitric oxide synthase (eNOS) gene is a definite risk factor for coronary spasm and whether diffuse spasm involving normal-looking coronary ..
  30. Via M, Gonzalez Perez E, Esteban E, López Alomar A, Vacca L, Vona G, et al. Molecular variation in endothelial nitric oxide synthase gene (eNOS) in western Mediterranean populations. Coll Antropol. 2003;27:117-24 pubmed
    Endothelial nitric oxide synthase (eNOS or NOS3) is the main responsible for nitric oxide (NO) production in vascular system and different polymorphisms have been identified in epidemiological studies...
  31. Sandrim V, de Syllos R, Lisboa H, Tres G, Tanus Santos J. Endothelial nitric oxide synthase haplotypes affect the susceptibility to hypertension in patients with type 2 diabetes mellitus. Atherosclerosis. 2006;189:241-6 pubmed
    Type 2 diabetes mellitus (T2DM) and hypertension (HT) commonly coexist. While endothelial nitric oxide synthase (eNOS) haplotypes have been associated with HT, it is unknown whether eNOS genotypes/haplotypes are associated with altered ..
  32. Cruz Gonzalez I, Corral E, Sanchez Ledesma M, Sánchez Rodríguez A, Martin Luengo C, Gonzalez Sarmiento R. Association between -T786C NOS3 polymorphism and resistant hypertension: a prospective cohort study. BMC Cardiovasc Disord. 2009;9:35 pubmed publisher
    ..24; p 0.004). Our results indicate that genotype -786CC of the NOS3 gene increase the susceptibility to suffer resistant hypertension, which suggest that resistance to conventional therapy could be determined at the endothelial level. ..
  33. Kim J, Chang H, Lee S, Kim J, Kim K, Lee S, et al. Endothelial nitric oxide synthase gene polymorphisms in Behçet's disease and rheumatic diseases with vasculitis. Ann Rheum Dis. 2003;62:1083-7 pubmed
    ..BD) or other rheumatic diseases with vasculitis and two polymorphisms of the endothelial nitric oxide synthase (eNOS) gene, which include the Glu298Asp polymorphism in exon 7 and a variable number of tandem repeats (VNTR) ..
  34. Duda D, Fukumura D, Jain R. Role of eNOS in neovascularization: NO for endothelial progenitor cells. Trends Mol Med. 2004;10:143-5 pubmed
    ..Recent data have revealed the predominant role of endothelial nitric oxide synthase (eNOS), an endothelial-cell-specific isoform of NO producing enzyme, in both angiogenesis (the development of new blood ..
  35. Theppeang K, Schwartz B, Lee B, Lustberg M, Silbergeld E, Kelsey K, et al. Associations of patella lead with polymorphisms in the vitamin D receptor, delta-aminolevulinic acid dehydratase and endothelial nitric oxide synthase genes. J Occup Environ Med. 2004;46:528-37 pubmed
    ..the vitamin D receptor (VDR), delta-aminolevulinic acid dehydratase (ALAD), and endothelial nitric oxide synthase (eNOS) genes with patella lead concentrations in 652 lead workers in the Republic of Korea...
  36. Fatini C, Sofi F, Gori A, Sticchi E, Marcucci R, Lenti M, et al. Endothelial nitric oxide synthase -786T>C, but not 894G>T and 4a4b, polymorphism influences plasma homocysteine concentrations in persons with normal vitamin status. Clin Chem. 2005;51:1159-64 pubmed
    ..The aim of this study was to investigate the role of endothelial nitric oxide synthase (eNOS) -786T>C, 894G>T, and 4a4b polymorphisms in influencing Hcy concentrations...
  37. Wolff B, Braun C, Schlüter C, Grabe H, Popowski K, Volzke H, et al. Endothelial nitric oxide synthase Glu(298)-->Asp polymorphism, carotid atherosclerosis and intima-media thickness in a general population sample. Clin Sci (Lond). 2005;109:475-81 pubmed
    The Glu(298)-->Asp (E298D; 894G-->T) polymorphism of eNOS (endothelial nitric oxide synthase) has been related with cardiovascular disease...
  38. Nakayama M, Yoshimura M, Sakamoto T, Abe K, Yamamuro M, Shono M, et al. A -786T>C polymorphism in the endothelial nitric oxide synthase gene reduces serum nitrite/nitrate levels from the heart due to an intracoronary injection of acetylcholine. Pharmacogenet Genomics. 2006;16:339-45 pubmed
    We identified a -786T>C polymorphism in the eNOS gene, and this polymorphism was strongly associated with coronary spasm...
  39. Godfrey V, Chan S, Cassidy A, Butler R, Choy A, Fardon T, et al. The functional consequence of the Glu298Asp polymorphism of the endothelial nitric oxide synthase gene in young healthy volunteers. Cardiovasc Drug Rev. 2007;25:280-8 pubmed
    To assess the role of the endothelial nitric oxide synthase (eNOS) gene variant as a risk factor for atherosclerosis we sought to investigate whether the Glu298Asp polymorphism of the eNOS gene is associated with functional changes in the ..
  40. Nurkalem Z, Tangurek B, Zencirci E, Alper A, Aksu H, Erer B, et al. Endothelial nitric oxide synthase gene (T-786C) polymorphism in patients with slow coronary flow. Coron Artery Dis. 2008;19:85-8 pubmed publisher
    ..we aimed to investigate the relationship between T-786C polymorphism of the endothelial nitric oxide synthase (eNOS) gene and slow coronary flow (SCF)...
  41. Guldiken B, Sipahi T, Guldiken S, Ustundag S, Budak M, Turgut N, et al. Glu298Asp polymorphism of the endothelial nitric oxide synthase gene in Turkish patients with ischemic stroke. Mol Biol Rep. 2009;36:1539-43 pubmed publisher
    ..and the genotypic distribution of the Glu298Asp gene polymorphism at exon 7 of endothelial nitric oxide synthase (eNOS) gene in Turkish ischemic stroke patients compared to appropriate healthy controls, and to correlate the genetic ..
  42. Sivasli E, Babaoglu M, Yasar U, Yurdakok M, Bozkurt A, Korkmaz A, et al. Association between the Glu298Asp and T(-786)C polymorphisms of the endothelial nitric oxide synthase gene and respiratory distress in preterm neonates. Turk J Pediatr. 2010;52:145-9 pubmed
    Genetic polymorphisms in the gene that codes for endothelial nitric oxide synthase (eNOS) have been associated with less nitric oxide availability and with various cardiovascular diseases in humans...
  43. El Din Bessa S, Hamdy S. Impact of nitric oxide synthase Glu298Asp polymorphism on the development of end-stage renal disease in type 2 diabetic Egyptian patients. Ren Fail. 2011;33:878-84 pubmed publisher
    ..This study aimed to investigate the role of endothelial nitric oxide synthase (eNOS) gene polymorphism in type 2 diabetic patients with end-stage renal disease (ESRD) and to elucidate any alteration ..
  44. Gratton J, Fontana J, O Connor D, Garcia Cardena G, McCabe T, Sessa W. Reconstitution of an endothelial nitric-oxide synthase (eNOS), hsp90, and caveolin-1 complex in vitro. Evidence that hsp90 facilitates calmodulin stimulated displacement of eNOS from caveolin-1. J Biol Chem. 2000;275:22268-72 pubmed
    The activity of endothelial nitric-oxide synthase (eNOS) is regulated by its subcellular localization, phosphorylation and through its interaction with different proteins...
  45. Noiri E, Satoh H, Taguchi J, Brodsky S, Nakao A, Ogawa Y, et al. Association of eNOS Glu298Asp polymorphism with end-stage renal disease. Hypertension. 2002;40:535-40 pubmed
    ..The present study aimed to elucidate the Glu298Asp polymorphism of endothelial NO synthase (eNOS) in patients with end-stage renal disease (ESRD) and its role as a predisposing factor for cardiovascular ..
  46. Fulton D, Babbitt R, Zoellner S, Fontana J, Acevedo L, McCabe T, et al. Targeting of endothelial nitric-oxide synthase to the cytoplasmic face of the Golgi complex or plasma membrane regulates Akt- versus calcium-dependent mechanisms for nitric oxide release. J Biol Chem. 2004;279:30349-57 pubmed
    The heterogeneous localization of endothelial nitricoxide synthase (eNOS) on the Golgi complex versus the plasma membrane has made it difficult to dissect the regulation of each pool of enzyme...
  47. Afrasyap L, Ozturk G. NO level and endothelial NO synthase gene polymorphism (Glu298Asp) in the patients with coronary artery disease from the Turkish population. Acta Biochim Biophys Sin (Shanghai). 2004;36:661-6 pubmed
    Nitric oxide is synthesized from L-arginine by endothelial nitric oxide synthase encoded by eNOS gene...
  48. Sandrim V, Coelho E, Nobre F, Arado G, Lanchote V, Tanus Santos J. Susceptible and protective eNOS haplotypes in hypertensive black and white subjects. Atherosclerosis. 2006;186:428-32 pubmed
    Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene have been inconsistently associated with hypertension...
  49. Tangurek B, Ozer N, Sayar N, Terzi S, Yilmaz H, Dayi S, et al. The relationship between endothelial nitric oxide synthase gene polymorphism (T-786 C) and coronary artery disease in the Turkish population. Heart Vessels. 2006;21:285-90 pubmed
    Previous studies revealed that there were various mutations on endothelial nitric oxide synthase (eNOS) gene and these mutations might be a risk factor for coronary artery disease (CAD), myocardial infarction (MI), and hypertension (HT)...
  50. Szabó G, Kunstár A, Acsády G. Methylentetrahydrofolate reductase and nitric oxide synthase polymorphism in patients with atherosclerosis and diabetes. Pathol Oncol Res. 2009;15:631-7 pubmed publisher
    ..Therefore in this study we investigated whether the eNOS and MTHFR gene polymorphisms is associated with myocardial infarction and stroke in patients with or without ..
  51. Safarinejad M, Khoshdel A, Shekarchi B, Taghva A, Safarinejad S. Association of the T-786C, G894T and 4a/4b polymorphisms of the endothelial nitric oxide synthase gene with vasculogenic erectile dysfunction in Iranian subjects. BJU Int. 2011;107:1994-2001 pubmed publisher
    ..of the T-786C, G894T and variable number of tandem repeats (VNTRs) in intron 4 (a/b) polymorphisms of the eNOS gene in Iranian subjects with vasculogenic erectile dysfunction (ED)...
  52. Medeiros R, Morais A, Vasconcelos A, Costa S, Carrilho S, Oliveira J, et al. Endothelial nitric oxide synthase gene polymorphisms and the shedding of circulating tumour cells in the blood of prostate cancer patients. Cancer Lett. 2003;189:85-90 pubmed
    The involvement of endothelial nitric oxide synthase (ecNOS) gene polymorphisms (ecNOS4a/b and Glu-Asp298) on the shedding of tumor cells in the blood of 61 patients with prostate cancer (PCa), was analyzed...
  53. Webb A, Milsom A, Rathod K, Chu W, Qureshi S, Lovell M, et al. Mechanisms underlying erythrocyte and endothelial nitrite reduction to nitric oxide in hypoxia: role for xanthine oxidoreductase and endothelial nitric oxide synthase. Circ Res. 2008;103:957-64 pubmed publisher
    ..Whereas endothelial nitric oxide synthase (eNOS) inhibition had no effect on vascular nitrite reductase activity, in RBCs L-NAME, L-NMMA, and L-arginine inhibited ..
  54. Li Y, Zhai Z, Yang Y, Pang B, Wang H, Zhang W, et al. Association of the 894G>T polymorphism in the endothelial nitric oxide synthase gene with risk of venous thromboembolism in Chinese population. Thromb Res. 2011;127:324-7 pubmed publisher
    Endothelium derived nitric oxide (NO) is a key mediator of vascular homeostasis. Endothelial nitric oxide synthase (eNOS) gene, by affecting the expression and functional activity of the eNOS enzyme, thereby reducing NO availability, may ..
  55. Tanus Santos J, Desai M, Flockhart D. Effects of ethnicity on the distribution of clinically relevant endothelial nitric oxide variants. Pharmacogenetics. 2001;11:719-25 pubmed
    Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene have been associated inconsistently with cardiovascular diseases...
  56. Landau R, Xie H, Dishy V, Wood A, Stein C, Smiley R. No association of the Asp298 variant of the endothelial nitric oxide synthase gene with preeclampsia. Am J Hypertens. 2004;17:391-4 pubmed
    ..Polymorphisms of the endothelial nitric oxide synthase (eNOS) gene affect NO production and have been associated with hypertension and preeclampsia in a Japanese population...
  57. Rusai K, Vannay A, Szebeni B, Borgulya G, Fekete A, Vasarhelyi B, et al. Endothelial nitric oxide synthase gene T-786C and 27-bp repeat gene polymorphisms in retinopathy of prematurity. Mol Vis. 2008;14:286-90 pubmed
    ..Endothelial nitric oxide synthase (eNOS) is believed to play a central role in both retinal angiogenesis and vasculogenesis...
  58. Sandrim V, Palei A, Cavalli R, Araújo F, Ramos E, Duarte G, et al. eNOS haplotypes associated with gestational hypertension or preeclampsia. Pharmacogenomics. 2008;9:1467-73 pubmed publisher
    Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene have been inconsistently associated with preeclampsia...
  59. Möllsten A, Lajer M, Jorsal A, Tarnow L. The endothelial nitric oxide synthase gene and risk of diabetic nephropathy and development of cardiovascular disease in type 1 diabetes. Mol Genet Metab. 2009;97:80-4 pubmed publisher
    ..Our conclusion is that the NOS3-gene may be involved in the development of diabetic nephropathy in patients with type 1 diabetes and can be predictive of CVD during follow-up. ..
  60. Majumdar V, Nagaraja D, Karthik N, Christopher R. Association of endothelial nitric oxide synthase gene polymorphisms with early-onset ischemic stroke in South Indians. J Atheroscler Thromb. 2010;17:45-53 pubmed
    ..to investigate the association of T-786C, G894T and 4a/b polymorphisms in the endothelial nitric oxide synthase (eNOS) gene with early-onset ischemic stroke in South Indians...
  61. Salvi E, Kutalik Z, Glorioso N, Benaglio P, Frau F, Kuznetsova T, et al. Genomewide association study using a high-density single nucleotide polymorphism array and case-control design identifies a novel essential hypertension susceptibility locus in the promoter region of endothelial NO synthase. Hypertension. 2012;59:248-55 pubmed publisher
    ..This finding supports the hypothesis that there may be a causal genetic variation at this locus. ..
  62. Magalhães da Silva T, Rocha A, Lacchini R, Marques C, Silva E, Tanus Santos J, et al. Association of polymorphisms of endothelial nitric oxide synthase (eNOS) gene with the risk of primary open angle glaucoma in a Brazilian population. Gene. 2012;502:142-6 pubmed publisher
    The present study aimed to investigate the association of endothelial nitric oxide synthase (eNOS) gene polymorphisms with primary open angle glaucoma (POAG)...
  63. Zhang R, Min W, Sessa W. Functional analysis of the human endothelial nitric oxide synthase promoter. Sp1 and GATA factors are necessary for basal transcription in endothelial cells. J Biol Chem. 1995;270:15320-6 pubmed
    To gain insights into the mechanisms of endothelial nitric oxide synthase (eNOS) gene expression, we have cloned the eNOS promoter and fused it to a luciferase reporter gene to map regions of the promoter important for basal transcription ..
  64. Sandrim V, Yugar Toledo J, Desta Z, Flockhart D, Moreno H, Tanus Santos J. Endothelial nitric oxide synthase haplotypes are related to blood pressure elevation, but not to resistance to antihypertensive drug therapy. J Hypertens. 2006;24:2393-7 pubmed
    ..Although endothelial nitric oxide synthase (eNOS) haplotypes have been associated with hypertension, it is unknown whether eNOS genotypes/haplotypes are associated ..
  65. Bhandary U, Bhandary U, Tse W, Yang B, Knowles M, Demaine A. Endothelial nitric oxide synthase polymorphisms are associated with hypertension and cardiovascular disease in renal transplantation. Nephrology (Carlton). 2008;13:348-55 pubmed publisher
    ..6% and 30.1%, respectively, P < 0.025; -786C: 54.2%, 42.8% and 34.4%, respectively, P < 0.01). The 894T and -786C alleles of the NOS3 gene were significantly associated with both hypertension and CVD in renal allograft recipients. ..
  66. Cherney D, Scholey J, Zhou J, Zimpelmann J, Kennedy C, Burns K, et al. Endothelial nitric oxide synthase gene polymorphisms and the renal hemodynamic response to L-arginine. Kidney Int. 2009;75:327-32 pubmed publisher
    ..Some studies found that a polymorphism (G894T) in the endothelial NOS gene was associated with decreased nitric oxide bioactivity and vascular complications...
  67. Lembo G, De Luca N, Battagli C, Iovino G, Aretini A, Musicco M, et al. A common variant of endothelial nitric oxide synthase (Glu298Asp) is an independent risk factor for carotid atherosclerosis. Stroke. 2001;32:735-40 pubmed
    Endothelium-derived NO is formed from L-arginine by endothelial NO synthase (eNOS) encoded by the NOS 3 gene on chromosome 7...
  68. Nagib El Kilany G, Nayel E, Hazzaa S. Nitric oxide synthase gene G298 allele. Is it a marker for microvascular angina in hypertensive patients?. Cardiovasc Radiat Med. 2004;5:113-8 pubmed
    ..The aim of the present study is to investigate the gene of endothelial nitric oxide synthase (eNOS), as the polymorphism of this gene may be a putative candidate for HPN and initiate the process of atherosclerosis...
  69. Wang G, Moniri N, Ozawa K, Stamler J, Daaka Y. Nitric oxide regulates endocytosis by S-nitrosylation of dynamin. Proc Natl Acad Sci U S A. 2006;103:1295-300 pubmed
  70. Kang J, Wiggs J, Rosner B, Hankinson S, Abdrabou W, Fan B, et al. Endothelial nitric oxide synthase gene variants and primary open-angle glaucoma: interactions with sex and postmenopausal hormone use. Invest Ophthalmol Vis Sci. 2010;51:971-9 pubmed publisher
    ..Interactions were observed between NOS3 SNPs and female sex and postmenopausal hormone use in the women in relation to HTPOAG. These findings should be confirmed in different racial/ethnic groups. ..
  71. Jafari Y, Rahimi Z, Vaisi raygani A, Rezaei M. Interaction of eNOS polymorphism with MTHFR variants increase the risk of diabetic nephropathy and its progression in type 2 diabetes mellitus patients. Mol Cell Biochem. 2011;353:23-34 pubmed publisher
    The present study has investigated the role of endothelial nitric oxide (eNOS) G894T polymorphism and its interaction with methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C variants on the predisposition to diabetic nephropathy ..
  72. Peck G, Smeeth L, Whittaker J, Casas J, Hingorani A, Sharma P. The genetics of primary haemorrhagic stroke, subarachnoid haemorrhage and ruptured intracranial aneurysms in adults. PLoS ONE. 2008;3:e3691 pubmed publisher
    ..Importantly, for several alleles previously found to be associated with protection from ischaemic stroke, there was a trend towards an increased risk of haemorrhagic stroke. ..
  73. Popov A, Henker C, Schmitto J, Wiese C, Coskun K, Moerer O, et al. Clinical relevance of eNOS T-786C polymorphism for hospital mortality and morbidity in cardiac surgical patients. J Cardiovasc Surg (Torino). 2010;51:265-72 pubmed
    The endothelial nitric oxide (eNOS) gene T-786C polymorphism may influence as a genetic risk factor cardiovascular diseases and shows association with cardiovascular mortality...
  74. Min B, Na J, Juhng S, Park M, Park J, Kim H. A polymorphism (G894T) in eNOS increases the risk of coronary atherosclerosis rather than intracranial atherosclerosis in Koreans. Acta Neurol Belg. 2010;110:255-62 pubmed
    The aim of this study was to investigate whether genetic variations in the eNOS gene were associated with intracranial and extracranial atherosclerosis in Koreans...
  75. Shoukry A, Shalaby S, Abdelazim S, Abdelazim M, Ramadan A, Ismail M, et al. Endothelial nitric oxide synthase gene polymorphisms and the risk of diabetic nephropathy in type 2 diabetes mellitus. Genet Test Mol Biomarkers. 2012;16:574-9 pubmed publisher
    ..Endothelial nitric oxide synthase (eNOS) gene polymorphisms that affect eNOS activity are associated with endothelial dysfunction...
  76. Degen B, Schmidt S, Ritz E. A polymorphism in the gene for the endothelial nitric oxide synthase and diabetic nephropathy. Nephrol Dial Transplant. 2001;16:185 pubmed
  77. Fricker R, Hesse C, Weiss J, Tayrouz Y, Hoffmann M, Unnebrink K, et al. Endothelial venodilator response in carriers of genetic polymorphisms involved in NO synthesis and degradation. Br J Clin Pharmacol. 2004;58:169-77 pubmed
    Polymorphisms of the NOSIII gene and of the CYBA gene have been associated with a number of pathological conditions such as arterial hypertension, coronary artery disease, and myocardial infarction...
  78. Akagawa H, Kasuya H, Onda H, Yoneyama T, Sasahara A, Kim C, et al. Influence of endothelial nitric oxide synthase T-786C single nucleotide polymorphism on aneurysm size. J Neurosurg. 2005;102:68-71 pubmed
    Among patients with aneurysms, those with heterozygous (T/C) endothelial nitric oxide synthase (eNOS) T-786C single nucleotide polymorphism (SNP), a mutation reducing endothelial nitric oxide synthesis, are reported to have larger ..