eNOS

Summary

Gene Symbol: eNOS
Description: nitric oxide synthase 3
Alias: ECNOS, eNOS, nitric oxide synthase, endothelial, EC-NOS, NOS type III, NOSIII, cNOS, constitutive NOS, endothelial NOS, nitric oxide synthase 3 (endothelial cell), nitric oxide synthase 3 transcript variant eNOS-delta20, nitric oxide synthase 3 transcript variant eNOS-delta20-21, nitric oxide synthase 3 transcript variant eNOS-delta21
Species: human
Products:     eNOS

Top Publications

  1. Naber C, Baumgart D, Altmann C, Siffert W, Erbel R, Heusch G. eNOS 894T allele and coronary blood flow at rest and during adenosine-induced hyperemia. Am J Physiol Heart Circ Physiol. 2001;281:H1908-12 pubmed
    The 894T allele of a G894T polymorphism in the endothelial nitric oxide synthase (eNOS) gene is associated with decreased eNOS activity, cleavage of the protein, and endothelial dysfunction...
  2. Saini V, Bhatnagar M, Bhattacharjee J. Endothelial nitric oxide synthase Glu298Asp (G894T) gene polymorphism in coronary artery disease patients with type 2 diabetes mellitus. Diabetes Metab Syndr. 2012;6:106-9 pubmed publisher
    ..This study determined the role of endothelial nitric oxide synthase (eNOS) Glu298Asp polymorphism and intergenotypic variation of plasma nitric oxide (NO) levels in coronary artery disease (..
  3. Rahimi Z, Nourozi Rad R, Rahimi Z, Parsian A. Strong interaction between T allele of endothelial nitric oxide synthase with B1 allele of cholesteryl ester transfer protein TaqIB highly elevates the risk of coronary artery disease and type 2 diabetes mellitus. Hum Genomics. 2012;6:20 pubmed publisher
    ..004). Our findings, for the first time, indicate that NOS3 T allele strongly interacts with CETP B1 allele to augment the risk of CAD and T2DM in the population of Western Iran. ..
  4. Bianco B, Ghirelli Filho M, Cavalheiro C, Cavalcanti V, Peluso C, Gava M, et al. Variants in endothelial nitric oxide synthase (eNOS) gene in idiopathic infertile Brazilian men. Gene. 2013;519:13-7 pubmed publisher
    ..The aim of the study was to analyze the distribution of the of endothelial nitric oxide synthase (eNOS) gene (T-786C, G894T, e 4a/b) polymorphisms in idiopathic infertile Brazilian men and evaluate the possible role of ..
  5. Zigra A, Rallidis L, Anastasiou G, Merkouri E, Gialeraki A. eNOS gene variants and the risk of premature myocardial infarction. Dis Markers. 2013;34:431-6 pubmed publisher
    Endothelial nitric oxide synthase (eNOS) as well as nitric oxide play an important role in the regulation of cardiovascular function...
  6. Kanias T, Wang L, Lippert A, Kim Shapiro D, Gladwin M. Red blood cell endothelial nitric oxide synthase does not modulate red blood cell storage hemolysis. Transfusion. 2013;53:981-9 pubmed publisher
    The red blood cell (RBC) endothelial nitric oxide synthase (eNOS) has been shown to regulate intrinsic RBC rheologic properties, such as membrane deformability, suggesting that a functional eNOS could be important in RBC viability and ..
  7. Cheema B, Kohli H, Sharma R, Bhansali A, Khullar M. Endothelial nitric oxide synthase gene polymorphism and type 2 diabetic retinopathy among Asian Indians. Acta Diabetol. 2012;49:481-8 pubmed publisher
    Endothelial nitric oxide synthase (eNOS) has been shown to play an essential role in retinal vascular function, and disequilibrium in its production can lead to diabetic retinopathy (DR)...
  8. Horn P, Cortese Krott M, Amabile N, Hundsdörfer C, Kröncke K, Kelm M, et al. Circulating microparticles carry a functional endothelial nitric oxide synthase that is decreased in patients with endothelial dysfunction. J Am Heart Assoc. 2012;2:e003764 pubmed publisher
    ..and endothelial cells, we hypothesized that MPs may harbor functional enzymes including an endothelial NO synthase (eNOS). Using immunoprecipitation and Western blot analysis, we found that human circulating MPs carry an eNOS...
  9. Ekmekci A, Ozcan K, Gungor B, Abaci N, Osmonov D, Zencirci A, et al. The relationship between endothelial nitric oxide synthase 4a/4b gene polymorphism and premature coronary artery disease. Acta Cardiol. 2013;68:464-8 pubmed
    ..Endothelial nitric oxide synthase (eNOS) intron 4a/b polymorphism has been shown to be related to plasma nitric oxide concentrations and coronary artery ..

More Information

Publications117 found, 100 shown here

  1. Yang Y, Du K, Liu Z, Lu X. Endothelial nitric oxide synthase (eNOS) 4b/a gene polymorphisms and coronary artery disease: evidence from a meta-analysis. Int J Mol Sci. 2014;15:7987-8003 pubmed publisher
    A variety of studies have suggested that the 4b/a polymorphism in the endothelial nitric oxide synthase (eNOS) was associated with coronary artery disease (CAD) risk. However, the data remain conflicting...
  2. Weiss J, Fränkl S, Flammer J, Grieshaber M, Hollo G, Teuchner B, et al. No difference in genotype frequencies of polymorphisms of the nitric oxide pathway between Caucasian normal and high tension glaucoma patients. Mol Vis. 2012;18:2174-81 pubmed
    ..These results therefore suggest the absence of a relevant relationship with different glaucoma forms in Caucasians. ..
  3. Cortese Krott M, Rodriguez Mateos A, Sansone R, Kuhnle G, Thasian Sivarajah S, Krenz T, et al. Human red blood cells at work: identification and visualization of erythrocytic eNOS activity in health and disease. Blood. 2012;120:4229-37 pubmed publisher
    ..ESI-MS/MS-based peptide sequencing and enzymatic assay we further demonstrate that human RBCs contain an endothelial NOS (eNOS) that converts L-(3)H-arginine to L-(3)H-citrulline in a Ca(2+)/calmodulin-dependent fashion...
  4. Arun Kumar A, Umamaheswaran G, Padmapriya R, Balachandar J, Adithan C. Endothelial nitric oxide synthase gene polymorphisms and the risk of acute myocardial infarction in a South Indian population. Mol Biol Rep. 2013;40:1275-81 pubmed publisher
    ..05) but the odds ratio (0.6) did not show risk for MI. The present study showed lack of association between NOS3 gene polymorphisms and MI in South Indian population. ..
  5. Narne P, Ponnaluri K, Singh S, Siraj M, Ishaq M. Association of the genetic variants of endothelial nitric oxide synthase gene with angiographically defined coronary artery disease and myocardial infarction in South Indian patients with type 2 diabetes mellitus. J Diabetes Complications. 2013;27:255-61 pubmed publisher
    The polymorphic variants of endothelial nitric oxide synthase (eNOS) gene have been implicated in endothelial dysfunction and are highly relevant to macroangiopathies...
  6. Abdel Aziz T, Mohamed R. Association of endothelial nitric oxide synthase gene polymorphisms with classical risk factors in development of premature coronary artery disease. Mol Biol Rep. 2013;40:3065-71 pubmed publisher
    Genetic polymorphism of the endothelial nitric oxide synthase (eNOS) affects the pathogenesis of atherosclerosis and associated with premature coronary artery disease (PCAD)...
  7. Demirçubuk A, Coskun M, Demiryurek S, Dokuyucu R, Oztuzcu S, Taviloğlu Z, et al. Endothelial NOS gene Glu298Asp polymorphism in preterm neonates with respiratory distress syndrome. Pediatr Pulmonol. 2013;48:976-80 pubmed publisher
    ..According to few studies in recent years, endothelial nitric oxide synthase (eNOS) gene polymorphisms are found to be partially responsible for liability to RDS...
  8. Tian G, Zeng X, Wang X, Zhang L, Zhang W, Wei W. Association between the endothelial nitric oxide synthase gene Glu298Asp polymorphism and coronary heart disease: a meta?analysis of 39 case?control studies. Mol Med Rep. 2013;7:1310-8 pubmed publisher
    Numerous studies have indicated that the human endothelial nitric oxide synthase (eNOS) gene Glu298Asp polymorphism is associated with coronary heart disease (CHD) susceptibility, however, their conclusions are inconsistent...
  9. Kallel A, Sbaï M, Sediri Y, Abdessalem S, Mourali M, Feki M, et al. Polymorphisms of the NOS3 gene and risk of myocardial infarction in the Tunisian population. Cytokine. 2013;64:646-51 pubmed publisher
    Controversial results regarding the association of eNOS gene (NOS3) polymorphisms with myocardial infarction (MI) have been reported...
  10. Liu J, Sessa W. Identification of covalently bound amino-terminal myristic acid in endothelial nitric oxide synthase. J Biol Chem. 1994;269:11691-4 pubmed
    Endothelial nitric oxide synthase (eNOS) is unique among the nitric oxide synthase family of proteins due to the presence of an N-myristoylation consensus sequence elucidated from the cloning of its cDNA...
  11. Hillermann R, Carelse K, Gebhardt G. The Glu298Asp variant of the endothelial nitric oxide synthase gene is associated with an increased risk for abruptio placentae in pre-eclampsia. J Hum Genet. 2005;50:415-9 pubmed
    ..gene variant Met235Threo, which has been associated with pre-eclampsia and the endothelial nitric oxide synthase (eNOS) polymorphism Glu298Asp, which has been associated with both pre-eclampsia and abruptio placentae, a condition that ..
  12. Oess S, Icking A, Fulton D, Govers R, Muller Esterl W. Subcellular targeting and trafficking of nitric oxide synthases. Biochem J. 2006;396:401-9 pubmed
    ..In the present review, we discuss the mechanisms and triggers for subcellular routing and dynamic redistribution of NO synthases and the ensuing consequences for NO production and action. ..
  13. Song J, Kim O, Kim H, Bae S, Hong S, Oh D, et al. Endothelial nitric oxide synthase gene polymorphisms and the risk of silent brain infarction. Int J Mol Med. 2010;25:819-23 pubmed
    ..In this study, we investigated polymorphisms in the endothelial nitric oxide synthase (eNOS) gene (i.e., -786T>C, 4a4b and 894G>T) as possible risk factors for SBI...
  14. Ghazali D, Rehman A, Rahman A. Candidate gene polymorphisms and their association with hypertension in Malays. Clin Chim Acta. 2008;388:46-50 pubmed
    ..A single nucleotide variant of the angiotensinogene gene (AGT M235T) and endothelial nitric oxide synthase gene (eNOS G894T) have been associated with hypertension...
  15. Berdeli A, Sekuri C, Sirri Cam F, Ercan E, Sagcan A, Tengiz I, et al. Association between the eNOS (Glu298Asp) and the RAS genes polymorphisms and premature coronary artery disease in a Turkish population. Clin Chim Acta. 2005;351:87-94 pubmed
    ..Our objective was to investigate the association between the polymorphisms of eNOS (Glu298Asp) and the RAS genes and premature CAD in a Turkish population...
  16. Persu A, Stoenoiu M, Messiaen T, Davila S, Robino C, El Khattabi O, et al. Modifier effect of ENOS in autosomal dominant polycystic kidney disease. Hum Mol Genet. 2002;11:229-41 pubmed
    ..Thus, ENOS, the gene coding for the endothelial nitric oxide synthase (eNOS), could have a modifier effect in ADPKD...
  17. Rodríguez Esparragón F, Rodriguez Perez J, Macías Reyes A, Alamo Santana F. Peroxisome proliferator-activated receptor-gamma2-Pro12Ala and endothelial nitric oxide synthase-4a/bgene polymorphisms are associated with essential hypertension. J Hypertens. 2003;21:1649-55 pubmed
    ..The endothelial nitric oxide synthase (eNOS) (4a/b) gene polymorphism contributes to coronary heart disease and hypertension risk...
  18. Fatini C, Sofi F, Sticchi E, Gensini F, Gori A, Fedi S, et al. Influence of endothelial nitric oxide synthase gene polymorphisms (G894T, 4a4b, T-786C) and hyperhomocysteinemia on the predisposition to acute coronary syndromes. Am Heart J. 2004;147:516-21 pubmed
    ..In this study we investigated the role of endothelial nitric oxide synthase (eNOS) polymorphisms as predisposing factors to acute coronary syndromes (ACS)...
  19. Nelson K, Dambrosia J, Iovannisci D, Cheng S, Grether J, Lammer E. Genetic polymorphisms and cerebral palsy in very preterm infants. Pediatr Res. 2005;57:494-9 pubmed
    ..polymorphisms (SNPs) showing evidence of association with development of CP were endothelial nitric oxide synthase (eNOS) A(-922)G, factor 7 (F7) arg353gln and del(-323)10bp-ins, and lymphotoxin A (LTA) thr26asn...
  20. Sandrim V, de Syllos R, Lisboa H, Tres G, Tanus Santos J. Influence of eNOS haplotypes on the plasma nitric oxide products concentrations in hypertensive and type 2 diabetes mellitus patients. Nitric Oxide. 2007;16:348-55 pubmed
    Endothelial nitric oxide synthase (eNOS) haplotypes are associated with hypertension (HT) in patients with or without type 2 diabetes mellitus (T2DM)...
  21. Tamemoto H, Ishikawa S, Kawakami M. Association of the Glu298Asp polymorphism of the eNOS Gene with ischemic heart disease in Japanese diabetic subjects. Diabetes Res Clin Pract. 2008;80:275-9 pubmed publisher
    We analysed the association of the Glu298Asp polymorphism of the endothelial nitric oxide synthase (eNOS) gene with ischemic heart disease (IHD) and albuminuria in 337 Japanese diabetes patients...
  22. Mamoulakis D, Bitsori M, Galanakis E, Vazgiourakis V, Panierakis C, Goulielmos G. Intron 4 polymorphism of the endothelial nitric oxide synthase eNOS gene and early microangiopathy in type 1 diabetes. Int J Immunogenet. 2009;36:153-7 pubmed publisher
    ..Endothelium-derived NO is formed from L-arginine by endothelial NO synthase (eNOS), and earlier studies have provided evidence for altered NO metabolism and impaired endothelial function in ..
  23. Tsujita Y, Baba S, Yamauchi R, Mannami T, Kinoshita M, Yamamoto R, et al. Association analyses between genetic polymorphisms of endothelial nitric oxide synthase gene and hypertension in Japanese: The Suita Study. J Hypertens. 2001;19:1941-8 pubmed
    ..Recently, endothelial nitric oxide synthase (eNOS) gene polymorphisms were reported to be associated with hypertension or coronary spasm...
  24. Zhang M, Zhang C, Shen Y, Wang J, Li X, Zhang Y, et al. Biogenesis of short intronic repeat 27-nucleotide small RNA from endothelial nitric-oxide synthase gene. J Biol Chem. 2008;283:14685-93 pubmed publisher
    Endothelial nitric-oxide synthase (eNOS) is a constitutively expressed gene in endothelium that produces NO and is critical for vascular integrity...
  25. Seremak Mrozikiewicz A, Drews K, Barlik M, Sieroszewski P, Grzeskowiak E, Mrozikiewicz P. The significance of -786T > C polymorphism of endothelial NO synthase (eNOS) gene in severe preeclampsia. J Matern Fetal Neonatal Med. 2011;24:432-6 pubmed publisher
    ..Highly polymorphic endothelial nitric oxide synthase (eNOS) activity belongs to the factors significantly influencing vaso-motor tone in placenta and PE susceptibility...
  26. Kang J, Wiggs J, Rosner B, Haines J, Abdrabou W, Pasquale L. Endothelial nitric oxide synthase gene variants and primary open-angle glaucoma: interactions with hypertension, alcohol intake, and cigarette smoking. Arch Ophthalmol. 2011;129:773-80 pubmed publisher
    ..004). Interactions were not observed with alcohol intake. The associations between hypertension and cigarette smoking in relation to POAG depended on NOS3 SNPs. ..
  27. Besler C, Heinrich K, Rohrer L, Doerries C, Riwanto M, Shih D, et al. Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease. J Clin Invest. 2011;121:2693-708 pubmed publisher
    ..of HDL are highly heterogeneous, and the impact of HDL of patients with CAD on the activation of endothelial eNOS and eNOS-dependent pathways is unknown...
  28. Gan Y, Chen C. The 27-bp VNTR polymorphism in intron 4 of the human eNOS gene in healthy Singaporean Chinese, Indians, and Malays. Biochem Genet. 2012;50:52-62 pubmed publisher
    Human endothelial nitric oxide synthase (eNOS) is one isoform of the nitric oxide synthases that are responsible for nitric oxide synthesis from L-arginine. The gene encoding eNOS contains a 27-bp VNTR polymorphism in intron 4...
  29. Rahimi Z, Vaisi raygani A, Rahimi Z, Parsian A. Concomitant presence of endothelial nitric oxide 894T and angiotensin II-converting enzyme D alleles are associated with diabetic nephropathy in a Kurdish population from Western Iran. Nephrology (Carlton). 2012;17:175-81 pubmed publisher
    ..D) polymorphism of the angiotensin II-converting enzyme (ACE) gene in combination with endothelial nitric oxide (eNOS) G894T polymorphism on the predisposition to diabetic nephropathy (DN)...
  30. Wu Z, Xiong Y, Gajanayake T, Ming X, Yang Z. p38 Mitogen-activated protein kinase is required for glucosamine-induced endothelial nitric oxide synthase uncoupling and plasminogen-activator inhibitor expression. Circ J. 2012;76:2015-22 pubmed
    ..HBP) is implicated in increased plasminogen activator inhibitor-1 (PAI-1), and endothelial nitric oxide synthase (eNOS) dysfunction in diabetes...
  31. Lee W, Hwang T, Oh G, Kwon S, Choi Y, Park J. Genetic factors associated with endothelial dysfunction affect the early onset of coronary artery disease in Korean males. Vasc Med. 2001;6:103-8 pubmed
    ..with endothelial function and the development of coronary artery disease (CAD), endothelial nitric oxide synthase (ecNOS) gene a/b polymorphism and NADH/NADPH oxidase p22 phox gene C242T polymorphism were examined in 305 Korean male ..
  32. Tempfer C, Dorman K, Deter R, O Brien W, Gregg A. An endothelial nitric oxide synthase gene polymorphism is associated with preeclampsia. Hypertens Pregnancy. 2001;20:107-18 pubmed
    ..01). These data provide evidence for an association between NOS3 and preeclampsia. In defined ethnic groups, this NOS3 may offer predictive information regarding the subsequent development of preeclampsia and its clinical course. ..
  33. Medeiros R, Morais A, Vasconcelos A, Costa S, Pinto D, Oliveira J, et al. Outcome in prostate cancer: association with endothelial nitric oxide synthase Glu-Asp298 polymorphism at exon 7. Clin Cancer Res. 2002;8:3433-7 pubmed
    The endothelial cell-specific form of nitric oxide synthases (ecNOS) was mapped at 7q35-q36 and plays an important role in vascular development and tumor growth in human prostate cancer...
  34. Pereira A, Sposito A, Mota G, Cunha R, Herkenhoff F, Mill J, et al. Endothelial nitric oxide synthase gene variant modulates the relationship between serum cholesterol levels and blood pressure in the general population: new evidence for a direct effect of lipids in arterial blood pressure. Atherosclerosis. 2006;184:193-200 pubmed
    ..We tested for an association of the expressed NO synthase (eNOS) Glu298Asp gene variant and plasma levels of lipids and lipoproteins in the determination of systolic blood ..
  35. Franks P, Luan J, Barroso I, Brage S, Gonzalez Sanchez J, Ekelund U, et al. Variation in the eNOS gene modifies the association between total energy expenditure and glucose intolerance. Diabetes. 2005;54:2795-801 pubmed
    ..Energy expenditure induces the endothelial NO synthase (eNOS) gene, providing a mechanism for insulin-independent glucose disposal...
  36. Salimi S, Firoozrai M, Nourmohammadi I, Shabani M, Mohebbi A. Endothelial nitric oxide synthase gene intron4 VNTR polymorphism in patients with coronary artery disease in Iran. Indian J Med Res. 2006;124:683-8 pubmed
    Endo-derived nitric oxide (NO) is synthesized from L-arginine by endothelium nitric oxide synthase (eNOS) encoded by the NOS3 gene on chromosome7...
  37. Cine N, Hatemi A, Erginel Unaltuna N. Association of a polymorphism of the ecNOS gene with myocardial infarction in a subgroup of Turkish MI patients. Clin Genet. 2002;61:66-70 pubmed
    In this study we examined a possible association between a 27 base pair (bp)-repeat polymorphism in intron 4 of the ecNOS gene and myocardial infarction (MI) in a subgroup of the Turkish population...
  38. Shimizu T, Onuma T, Kawamori R, Makita Y, Tomino Y. Endothelial nitric oxide synthase gene and the development of diabetic nephropathy. Diabetes Res Clin Pract. 2002;58:179-85 pubmed
    ..nephropathy Intron 4 insertion/deletion polymorphism of the constitutive endothelial nitric oxide synthase (ecNOS) gene may be related to diabetic nephropathy...
  39. Cattaruzza M, Guzik T, Słodowski W, Pelvan A, Becker J, Halle M, et al. Shear stress insensitivity of endothelial nitric oxide synthase expression as a genetic risk factor for coronary heart disease. Circ Res. 2004;95:841-7 pubmed
    ..The -786C/T SNP of the nos-3 gene thus constitutes a genetic risk factor for CHD, presumably due to binding of an inhibitory transcription factor to the C-type promoter blocking shear stress-dependent maintenance of NOS-3 expression. ..
  40. Chen W, Srinivasan S, Li S, Boerwinkle E, Berenson G. Gender-specific influence of NO synthase gene on blood pressure since childhood: the Bogalusa Heart Study. Hypertension. 2004;44:668-73 pubmed
    ..In conclusion, the endothelial NO synthase gene influences the long-term burden and trend of blood pressure since childhood in females and may contribute to their predisposition to hypertension. ..
  41. Gibson C, MacLennan A, Dekker G, Goldwater P, Dambrosia J, Munroe D, et al. Genetic polymorphisms and spontaneous preterm birth. Obstet Gynecol. 2007;109:384-91 pubmed
    ..cerebral palsy, preterm birth was associated with polymorphisms in genes for endothelial nitric oxide synthase (eNOS -922, P=.012), plasminogen activator inhibitor-2 (P=.015 and .019), and alpha adducin (ADD1, P=.047)...
  42. Zhang M, Zhang C, Shen Y, Wang J, Li X, Chen L, et al. Effect of 27nt small RNA on endothelial nitric-oxide synthase expression. Mol Biol Cell. 2008;19:3997-4005 pubmed publisher
    We have reported previously that the 27nt repeat polymorphism in endothelial nitric-oxide synthase (eNOS) intron 4--a source of 27nt small RNA--inhibits eNOS expression...
  43. Chen P, Wu K. Two synthetic peptides corresponding to the proximal heme-binding domain and CD1 domain of human endothelial nitric-oxide synthase inhibit the oxygenase activity by interacting with CaM. Arch Biochem Biophys. 2009;486:132-40 pubmed publisher
    Human endothelial nitric-oxide synthase (eNOS) is a complex enzyme, requiring binding of calmodulin (CaM) for electron transfer...
  44. Gad M, Abdel Rahman M, Hashad I, Abdel Maksoud S, Farag N, Abou Aisha K. Endothelial nitric oxide synthase (G894T) gene polymorphism in a random sample of the Egyptian population: comparison with myocardial infarction patients. Genet Test Mol Biomarkers. 2012;16:695-700 pubmed publisher
    The aim of this study was to detect endothelial nitric oxide synthase (eNOS) Glu298Asp gene variants in a random sample of the Egyptian population, compare it with those from other populations, and attempt to correlate these variants with ..
  45. Nadaud S, Bonnardeaux A, Lathrop M, Soubrier F. Gene structure, polymorphism and mapping of the human endothelial nitric oxide synthase gene. Biochem Biophys Res Commun. 1994;198:1027-33 pubmed
    ..A highly polymorphic (CA) repeat within intron 13 was studied, allowing the precise genetic mapping of the gene to chromosome 7, within a 4 cM interval delimited by genethon markers AFM199Zd4 and AFM074Xg5. ..
  46. Sofowora G, Dishy V, Xie H, Imamura H, Nishimi Y, Morales C, et al. In-vivo effects of Glu298Asp endothelial nitric oxide synthase polymorphism. Pharmacogenetics. 2001;11:809-14 pubmed
    ..This polymorphism may only have clinical significance in the presence of endothelial dysfunction. ..
  47. Medeiros R, Morais A, Vasconcelos A, Costa S, Pinto D, Oliveira J, et al. Endothelial nitric oxide synthase gene polymorphisms and genetic susceptibility to prostate cancer. Eur J Cancer Prev. 2002;11:343-50 pubmed
    The endothelial cell-specific form of nitric oxide synthases (ecNOS) is localized at 7q35-q36 and is involved in vascular development and tumour growth in human prostate cancer...
  48. Asensi V, Montes A, Valle E, Ocaña M, Astudillo A, Alvarez V, et al. The NOS3 (27-bp repeat, intron 4) polymorphism is associated with susceptibility to osteomyelitis. Nitric Oxide. 2007;16:44-53 pubmed
    ..This is the first report of an association between a NOS3 polymorphism and the risk of developing OM. ..
  49. Hu C, Wang C, Lee J, Hsieh C, Cheng C, Chang S, et al. Association between polymorphisms of ACE, B2AR, ANP and ENOS and cardiovascular diseases: a community-based study in the Matsu area. Clin Chem Lab Med. 2007;45:20-5 pubmed
    ..ACE), atrial natriuretic peptide (ANP), beta(2)-adrenal receptor (B2AR) and endothelial nitric oxide synthase (ENOS) genes were explored in a community-based setting...
  50. Yemisci M, Sinici I, Ozkara H, Hayran M, Ay H, Celtikci B, et al. Protective role of 27bp repeat polymorphism in intron 4 of eNOS gene in lacunar infarction. Free Radic Res. 2009;43:272-9 pubmed publisher
    Association of the three potential endothelial nitric oxide synthase gene (eNOS) polymorphisms (T-786C in promoter region, G894T in exon 7 and tandem 27-bp repeats in intron 4) with an increased risk of lacunar infarction (LI) were ..
  51. Aggarwal P, Jain V, Jha V. Endothelial nitric oxide synthase, angiotensin-converting enzyme and angiotensinogen gene polymorphisms in hypertensive disorders of pregnancy. Hypertens Res. 2010;33:473-7 pubmed publisher
    ..The complexity of interaction between these genetic abnormalities requires further studies. ..
  52. Safarinejad M, Safarinejad S, Shafiei N, Safarinejad S. Effects of the T-786C, G894T, and Intron 4 VNTR (4a/b) polymorphisms of the endothelial nitric oxide synthase gene on the risk of prostate cancer. Urol Oncol. 2013;31:1132-40 pubmed publisher
    ..Endothelial nitric oxide synthase (eNOS) gene polymorphisms significantly affects serum NO concentrations...
  53. Schmoelzer I, Renner W, Paulweber B, Malaimare L, Iglseder B, Schmid P, et al. Lack of association of the Glu298Asp polymorphism of endothelial nitric oxide synthase with manifest coronary artery disease, carotid atherosclerosis and forearm vascular reactivity in two Austrian populations. Eur J Clin Invest. 2003;33:191-8 pubmed
    ..We suggest additional investigations to be performed in populations at different risk for coronary events to further elucidate the possible contribution of this polymorphism to vascular disease. ..
  54. Xu J, Xie Z, Reece R, Pimental D, Zou M. Uncoupling of endothelial nitric oxidase synthase by hypochlorous acid: role of NAD(P)H oxidase-derived superoxide and peroxynitrite. Arterioscler Thromb Vasc Biol. 2006;26:2688-95 pubmed
    ..of leukocyte-derived myeloperoxidase (MPO), oxidizes the zinc-thiolate center of endothelial nitric oxide synthase (eNOS) and uncouples the enzyme...
  55. Augeri A, Tsongalis G, Van Heest J, Maresh C, Thompson P, Pescatello L. The endothelial nitric oxide synthase -786 T>C polymorphism and the exercise-induced blood pressure and nitric oxide responses among men with elevated blood pressure. Atherosclerosis. 2009;204:e28-34 pubmed publisher
    A polymorphism (-786 T>C) in the promoter region of the endothelial nitric oxide synthase gene (eNOS) has important functional characteristics...
  56. Safarinejad M, Shafiei N, Safarinejad S. The role of endothelial nitric oxide synthase (eNOS) T-786C, G894T, and 4a/b gene polymorphisms in the risk of idiopathic male infertility. Mol Reprod Dev. 2010;77:720-7 pubmed publisher
    ..This study aims to examine if there is an association between endothelial nitric oxide synthase (eNOS) T-786C, G894T, and 4a/b gene polymorphisms and idiopathic male infertility...
  57. Suganthalakshmi B, Anand R, Kim R, Mahalakshmi R, Karthikprakash S, Namperumalsamy P, et al. Association of VEGF and eNOS gene polymorphisms in type 2 diabetic retinopathy. Mol Vis. 2006;12:336-41 pubmed
    ..The objective of this study was to examine the genetic variations of the VEGF and eNOS gene and assess their possible relationship to DR in type 2 diabetic patients in the Indian population...
  58. Ji Y, Ferracci G, Warley A, Ward M, Leung K, Samsuddin S, et al. beta-Actin regulates platelet nitric oxide synthase 3 activity through interaction with heat shock protein 90. Proc Natl Acad Sci U S A. 2007;104:8839-44 pubmed
    ..These observations suggest that beta-actin plays a critical role in regulating NO formation and signaling in platelets. ..
  59. Imamura A, Takahashi R, Murakami R, Kataoka H, Cheng X, Numaguchi Y, et al. The effects of endothelial nitric oxide synthase gene polymorphisms on endothelial function and metabolic risk factors in healthy subjects: the significance of plasma adiponectin levels. Eur J Endocrinol. 2008;158:189-95 pubmed publisher
    Genetic variants of the endothelial nitric oxide synthase (eNOS) gene, Glu298Asp and T-786C, have been reported to be associated with cardiovascular disease...
  60. Katakami N, Kaneto H, Matsuoka T, Takahara M, Imamura K, Ishibashi F, et al. Accumulation of gene polymorphisms related to oxidative stress is associated with myocardial infarction in Japanese type 2 diabetic patients. Atherosclerosis. 2010;212:534-8 pubmed publisher
    ..Accumulation of gene polymorphisms related to oxidative stress is likely associated with the prevalence of MI in type 2 diabetic patients, suggesting that the combined information about these variants is useful to assess the risk of MI. ..
  61. Monti L, Barlassina C, Citterio L, Galluccio E, Berzuini C, Setola E, et al. Endothelial nitric oxide synthase polymorphisms are associated with type 2 diabetes and the insulin resistance syndrome. Diabetes. 2003;52:1270-5 pubmed
    Endothelial nitric oxide synthase (eNOS) variants were previously demonstrated in cardiovascular disease...
  62. Gouni Berthold I, Giannakidou E, Muller Wieland D, Faust M, Kotzka J, Berthold H, et al. Peroxisome proliferator-activated receptor-gamma2 Pro12Ala and endothelial nitric oxide synthase-4a/b gene polymorphisms are not associated with hypertension in diabetes mellitus type 2. J Hypertens. 2005;23:301-8 pubmed
    ..of the peroxisome proliferator-activated receptor gamma (PPARgamma) and the endothelial nitric oxide-synthase (eNOS) genes, respectively, have been associated with hypertension in some but not all studies...
  63. Sun L, Wang C, Wu A, Yan B, Li D, Zhang J, et al. [Gene polymorphism of the endothelial nitric oxide synthase enzyme and pulmonary hypertension in patient with chronic obstructive pulmonary disease]. Zhonghua Jie He He Hu Xi Za Zhi. 2008;31:335-40 pubmed
    ..In stepwise logistic regression analysis for predicting pulmonary artery pressure, the polymorphism of eNOS gene, the level of Nox and smoking were found to be independent variables...
  64. Esposti R, Sponton C, Malagrino P, Carvalho F, Peres E, Puga G, et al. Influence of eNOS gene polymorphism on cardiometabolic parameters in response to physical training in postmenopausal women. Braz J Med Biol Res. 2011;44:855-63 pubmed
    ..The objective of this study was to determine whether single nucleotide polymorphism of the endothelial NO synthase (eNOS) gene at positions -786T>C, G894T (Glu298Asp) and at the variable number of tandem repeat (VNTR) Intron 4b/a ..
  65. Bashford M, Hefler L, Vertrees T, Roa B, Gregg A. Angiotensinogen and endothelial nitric oxide synthase gene polymorphisms among Hispanic patients with preeclampsia. Am J Obstet Gynecol. 2001;184:1345-50; discussion 1350-1 pubmed
    ..10). The AGT*T allele was not associated with the development of preeclampsia. Independently of the presence of an AGT*T allele, the NOS3*A allele was associated with a higher blood pressure at an earlier gestational age. ..
  66. Nassar B, Bevin L, Johnstone D, O Neill B, Bata I, Kirkland S, et al. Relationship of the Glu298Asp polymorphism of the endothelial nitric oxide synthase gene and early-onset coronary artery disease. Am Heart J. 2001;142:586-9 pubmed
    The Glu298Asp polymorphism of endothelial nitric oxide synthase (eNOS) gene has been associated with coronary artery disease (CAD) in some but not all studies...
  67. Dell Omo G, Penno G, Pucci L, Fotino C, Lucchesi D, Del Prato S, et al. Lack of association between endothelial nitric oxide synthase gene polymorphisms, microalbuminuria and endothelial dysfunction in hypertensive men. J Hypertens. 2007;25:1389-95 pubmed
    ..To assess that hypothesis, we evaluated the association of albuminuria with eNOS genotypes and their interacting potential with the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) ..
  68. Pereira T, Rudnicki M, Cheung B, Baum L, Yamada Y, Oliveira P, et al. Three endothelial nitric oxide (NOS3) gene polymorphisms in hypertensive and normotensive individuals: meta-analysis of 53 studies reveals evidence of publication bias. J Hypertens. 2007;25:1763-74 pubmed
    ..Future research should preferentially focus on gene-environment interactions as well as haplotype analyses. ..
  69. Presciuttini S, Curcio M, Chillemi R, Barbuti S, Scatena F, Carli G, et al. Promoter polymorphisms of the NOS3 gene are associated with hypnotizability-dependent vascular response to nociceptive stimulation. Neurosci Lett. 2009;467:252-5 pubmed publisher
    ..b>Endothelial NOS is encoded by the NOS3 locus...
  70. Kuzmanić Samija R, Primorac D, Resic B, Lozić B, Krzelj V, Tomasović M, et al. Association of NOS3 tag polymorphisms with hypoxic-ischemic encephalopathy. Croat Med J. 2011;52:396-402 pubmed
    ..10 for rs3918227, OR=1.68 for rs1800779, and OR=1.76 for rs1799983, assuming an additive model. Despite the limited number of HIE patients, we observed genotypic and haplotype associations of NOS3 polymorphisms with HIE. ..
  71. Dahgam S, Nyberg F, Modig L, Naluai A, Olin A. Single nucleotide polymorphisms in the NOS2 and NOS3 genes are associated with exhaled nitric oxide. J Med Genet. 2012;49:200-5 pubmed publisher
    ..9%, 95% CI 4.6% to 42.0%). These results suggest that NOS2 is the major NOS gene determining variability in exhaled nitric oxide in the healthy adult population, while NOS3 may play a more important role in asthmatic adults. ..
  72. Lee Y, Cheon K, Lee H, Kim W, Rhee Y, Kim D. Gene polymorphisms of endothelial nitric oxide synthase and angiotensin-converting enzyme in patients with asthma. Allergy. 2000;55:959-63 pubmed
    Nitric oxide, including that produced by endothelial constitutive nitric oxide synthase (ecNOS), may regulate vascular and airway tone in the lungs and may influence various aspects of airway homeostasis...
  73. Karvonen J, Kauma H, Kervinen K, Rantala M, Ikäheimo M, Paivansalo M, et al. Endothelial nitric oxide synthase gene Glu298Asp polymorphism and blood pressure, left ventricular mass and carotid artery atherosclerosis in a population-based cohort. J Intern Med. 2002;251:102-10 pubmed
    ..the association between the Glu298Asp polymorphism of the NO producing gene, endothelial nitric oxide synthase (eNOS), and hypertension, left ventricular mass (LVM) and carotid artery intima-media thickness (IMT) in a population-..
  74. Topal G, Brunet A, Millanvoye E, Boucher J, Rendu F, Devynck M, et al. Homocysteine induces oxidative stress by uncoupling of NO synthase activity through reduction of tetrahydrobiopterin. Free Radic Biol Med. 2004;36:1532-41 pubmed
    ..Here, we examine the participation of endothelial NO synthase (eNOS) in the homocysteine-induced alterations of NO/O(2)(-) balance in endothelial cells from human umbilical cord vein...
  75. Kim Y, Park H, Lee H, Ha E, Suh S, Oh S, et al. Reduced L-arginine level and decreased placental eNOS activity in preeclampsia. Placenta. 2006;27:438-44 pubmed
    ..Moreover, it has been reported that asymmetric dimethylarginine (ADMA) acts as is an endogenous inhibitor of endothelial NOS (eNOS) by competing with the enzyme for L-arginine...
  76. Wang S, Davis S, Cerhan J, Hartge P, Severson R, Cozen W, et al. Polymorphisms in oxidative stress genes and risk for non-Hodgkin lymphoma. Carcinogenesis. 2006;27:1828-34 pubmed
  77. Olcay A, Ekmekci C, Ozbek U, Sezer M, Barcin C, Arslan E, et al. Negative association of endothelial nitric oxide gene polymorphism with hypertension in Turkish patients: effect of ecNOS polymorphism on left ventricular hypertrophy. Cardiovasc Ultrasound. 2006;4:33 pubmed
    ..0001. Endothelial nitric oxide synthase 4a/b gene polymorphism is not associated with hypertension in Turkish patients. 4a/a genotype was associated with higher interventricular septal thickness in hypertensive patients. ..
  78. Yeh C, Santella R, Hsieh L, Sung F, Tang R. An intron 4 VNTR polymorphism of the endothelial nitric oxide synthase gene is associated with early-onset colorectal cancer. Int J Cancer. 2009;124:1565-71 pubmed publisher
    Endothelial-derived nitric oxide, which is produced by endothelial nitric oxide synthase (eNOS), may play an important role in colorectal carcinogenesis...
  79. Kingah P, Luu H, Volcik K, Morrison A, Nettleton J, Boerwinkle E. Association of NOS3 Glu298Asp SNP with hypertension and possible effect modification of dietary fat intake in the ARIC study. Hypertens Res. 2010;33:165-9 pubmed publisher
    ..We recommend further exploration of the relationship between NOS3 Glu298Asp and triglycerides in African Americans. ..
  80. Schuller M, Stelcl M, Rybníèek O, Buèková D, Izakovièová Hollá L. The ecNOS gene in allergic Czech children. Allergy. 2002;57:368-9 pubmed
  81. Kerkeni M, Addad F, Chauffert M, Myara A, Ben Farhat M, Miled A, et al. Hyperhomocysteinemia, endothelial nitric oxide synthase polymorphism, and risk of coronary artery disease. Clin Chem. 2006;52:53-8 pubmed
    ..The G894T variant of endothelial nitric oxide synthase (eNOS) was postulated to be associated with hyperhomocysteinemia and could influence individual susceptibility to CAD...
  82. Xin Y, Song X, Xue H, Liu Z, Wang X, Wang H, et al. A common variant of the eNOS gene (E298D) is an independent risk factor for left ventricular hypertrophy in human essential hypertension. Clin Sci (Lond). 2009;117:67-73 pubmed publisher
    b>eNOS (endothelial NO synthase) plays a critical role in the development of ventricular remodelling and cardiac hypertrophy...
  83. Misono M, Maeda S, Iemitsu M, Nakata Y, Otsuki T, Sugawara J, et al. Combination of polymorphisms in the beta2-adrenergic receptor and nitric oxide synthase 3 genes increases the risk for hypertension. J Hypertens. 2009;27:1377-83 pubmed publisher
    ..We revealed that a combination of the Arg16Gly and Glu298Asp polymorphisms in ADRB2 and NOS3, respectively, remarkably increased the risk for hypertension in middle-aged and elderly humans. ..
  84. Testa A, Spoto B, Sanguedolce M, Parlongo R, Pisano A, Tripepi G, et al. eNOS and caveolin-1 gene polymorphisms interaction and intima media thickness: a proof of concept study in ESRD patients. Am J Hypertens. 2012;25:103-8 pubmed publisher
    ..in endothelial cells and appropriate localization in caveolae is fundamental for endothelial nitric oxide synthase (eNOS) activity...