eNOS

Summary

Gene Symbol: eNOS
Description: nitric oxide synthase 3
Alias: ECNOS, eNOS, nitric oxide synthase, endothelial, EC-NOS, NOS type III, NOSIII, cNOS, constitutive NOS, endothelial NOS, nitric oxide synthase 3 (endothelial cell), nitric oxide synthase 3 transcript variant eNOS-delta20, nitric oxide synthase 3 transcript variant eNOS-delta20-21, nitric oxide synthase 3 transcript variant eNOS-delta21
Species: human
Products:     eNOS

Top Publications

  1. Zhuo M, Huang Y, Chen J, Sun L, Yang R, Chen H, et al. Endothelium-specific overexpression of human IC53 downregulates endothelial nitric oxide synthase activity and elevates systolic blood pressure in mice. Cardiovasc Res. 2009;84:292-9 pubmed publisher
    ..endothelium-dependent vasodilation, reduced nitric oxide (NO) production and decreased endothelial NO synthase (eNOS) expression, and activity in the tg mice...
  2. Naber C, Baumgart D, Altmann C, Siffert W, Erbel R, Heusch G. eNOS 894T allele and coronary blood flow at rest and during adenosine-induced hyperemia. Am J Physiol Heart Circ Physiol. 2001;281:H1908-12 pubmed
    The 894T allele of a G894T polymorphism in the endothelial nitric oxide synthase (eNOS) gene is associated with decreased eNOS activity, cleavage of the protein, and endothelial dysfunction...
  3. Saini V, Bhatnagar M, Bhattacharjee J. Endothelial nitric oxide synthase Glu298Asp (G894T) gene polymorphism in coronary artery disease patients with type 2 diabetes mellitus. Diabetes Metab Syndr. 2012;6:106-9 pubmed publisher
    ..This study determined the role of endothelial nitric oxide synthase (eNOS) Glu298Asp polymorphism and intergenotypic variation of plasma nitric oxide (NO) levels in coronary artery disease (..
  4. Rahimi Z, Nourozi Rad R, Rahimi Z, Parsian A. Strong interaction between T allele of endothelial nitric oxide synthase with B1 allele of cholesteryl ester transfer protein TaqIB highly elevates the risk of coronary artery disease and type 2 diabetes mellitus. Hum Genomics. 2012;6:20 pubmed publisher
    ..004). Our findings, for the first time, indicate that NOS3 T allele strongly interacts with CETP B1 allele to augment the risk of CAD and T2DM in the population of Western Iran. ..
  5. Bianco B, Ghirelli Filho M, Cavalheiro C, Cavalcanti V, Peluso C, Gava M, et al. Variants in endothelial nitric oxide synthase (eNOS) gene in idiopathic infertile Brazilian men. Gene. 2013;519:13-7 pubmed publisher
    ..The aim of the study was to analyze the distribution of the of endothelial nitric oxide synthase (eNOS) gene (T-786C, G894T, e 4a/b) polymorphisms in idiopathic infertile Brazilian men and evaluate the possible role of ..
  6. Zigra A, Rallidis L, Anastasiou G, Merkouri E, Gialeraki A. eNOS gene variants and the risk of premature myocardial infarction. Dis Markers. 2013;34:431-6 pubmed publisher
    Endothelial nitric oxide synthase (eNOS) as well as nitric oxide play an important role in the regulation of cardiovascular function...
  7. Kanias T, Wang L, Lippert A, Kim Shapiro D, Gladwin M. Red blood cell endothelial nitric oxide synthase does not modulate red blood cell storage hemolysis. Transfusion. 2013;53:981-9 pubmed publisher
    The red blood cell (RBC) endothelial nitric oxide synthase (eNOS) has been shown to regulate intrinsic RBC rheologic properties, such as membrane deformability, suggesting that a functional eNOS could be important in RBC viability and ..
  8. Cheema B, Kohli H, Sharma R, Bhansali A, Khullar M. Endothelial nitric oxide synthase gene polymorphism and type 2 diabetic retinopathy among Asian Indians. Acta Diabetol. 2012;49:481-8 pubmed publisher
    Endothelial nitric oxide synthase (eNOS) has been shown to play an essential role in retinal vascular function, and disequilibrium in its production can lead to diabetic retinopathy (DR)...
  9. Horn P, Cortese Krott M, Amabile N, Hundsdörfer C, Kröncke K, Kelm M, et al. Circulating microparticles carry a functional endothelial nitric oxide synthase that is decreased in patients with endothelial dysfunction. J Am Heart Assoc. 2012;2:e003764 pubmed publisher
    ..and endothelial cells, we hypothesized that MPs may harbor functional enzymes including an endothelial NO synthase (eNOS). Using immunoprecipitation and Western blot analysis, we found that human circulating MPs carry an eNOS...

More Information

Publications399 found, 100 shown here

  1. Ekmekci A, Ozcan K, Gungor B, Abaci N, Osmonov D, Zencirci A, et al. The relationship between endothelial nitric oxide synthase 4a/4b gene polymorphism and premature coronary artery disease. Acta Cardiol. 2013;68:464-8 pubmed
    ..Endothelial nitric oxide synthase (eNOS) intron 4a/b polymorphism has been shown to be related to plasma nitric oxide concentrations and coronary artery ..
  2. Yang Y, Du K, Liu Z, Lu X. Endothelial nitric oxide synthase (eNOS) 4b/a gene polymorphisms and coronary artery disease: evidence from a meta-analysis. Int J Mol Sci. 2014;15:7987-8003 pubmed publisher
    A variety of studies have suggested that the 4b/a polymorphism in the endothelial nitric oxide synthase (eNOS) was associated with coronary artery disease (CAD) risk. However, the data remain conflicting...
  3. Weiss J, Fränkl S, Flammer J, Grieshaber M, Hollo G, Teuchner B, et al. No difference in genotype frequencies of polymorphisms of the nitric oxide pathway between Caucasian normal and high tension glaucoma patients. Mol Vis. 2012;18:2174-81 pubmed
    ..These results therefore suggest the absence of a relevant relationship with different glaucoma forms in Caucasians. ..
  4. Cortese Krott M, Rodriguez Mateos A, Sansone R, Kuhnle G, Thasian Sivarajah S, Krenz T, et al. Human red blood cells at work: identification and visualization of erythrocytic eNOS activity in health and disease. Blood. 2012;120:4229-37 pubmed publisher
    ..ESI-MS/MS-based peptide sequencing and enzymatic assay we further demonstrate that human RBCs contain an endothelial NOS (eNOS) that converts L-(3)H-arginine to L-(3)H-citrulline in a Ca(2+)/calmodulin-dependent fashion...
  5. Arun Kumar A, Umamaheswaran G, Padmapriya R, Balachandar J, Adithan C. Endothelial nitric oxide synthase gene polymorphisms and the risk of acute myocardial infarction in a South Indian population. Mol Biol Rep. 2013;40:1275-81 pubmed publisher
    ..05) but the odds ratio (0.6) did not show risk for MI. The present study showed lack of association between NOS3 gene polymorphisms and MI in South Indian population. ..
  6. Narne P, Ponnaluri K, Singh S, Siraj M, Ishaq M. Association of the genetic variants of endothelial nitric oxide synthase gene with angiographically defined coronary artery disease and myocardial infarction in South Indian patients with type 2 diabetes mellitus. J Diabetes Complications. 2013;27:255-61 pubmed publisher
    The polymorphic variants of endothelial nitric oxide synthase (eNOS) gene have been implicated in endothelial dysfunction and are highly relevant to macroangiopathies...
  7. Abdel Aziz T, Mohamed R. Association of endothelial nitric oxide synthase gene polymorphisms with classical risk factors in development of premature coronary artery disease. Mol Biol Rep. 2013;40:3065-71 pubmed publisher
    Genetic polymorphism of the endothelial nitric oxide synthase (eNOS) affects the pathogenesis of atherosclerosis and associated with premature coronary artery disease (PCAD)...
  8. Demirçubuk A, Coskun M, Demiryurek S, Dokuyucu R, Oztuzcu S, Taviloğlu Z, et al. Endothelial NOS gene Glu298Asp polymorphism in preterm neonates with respiratory distress syndrome. Pediatr Pulmonol. 2013;48:976-80 pubmed publisher
    ..According to few studies in recent years, endothelial nitric oxide synthase (eNOS) gene polymorphisms are found to be partially responsible for liability to RDS...
  9. Tian G, Zeng X, Wang X, Zhang L, Zhang W, Wei W. Association between the endothelial nitric oxide synthase gene Glu298Asp polymorphism and coronary heart disease: a meta?analysis of 39 case?control studies. Mol Med Rep. 2013;7:1310-8 pubmed publisher
    Numerous studies have indicated that the human endothelial nitric oxide synthase (eNOS) gene Glu298Asp polymorphism is associated with coronary heart disease (CHD) susceptibility, however, their conclusions are inconsistent...
  10. Kallel A, Sbaï M, Sediri Y, Abdessalem S, Mourali M, Feki M, et al. Polymorphisms of the NOS3 gene and risk of myocardial infarction in the Tunisian population. Cytokine. 2013;64:646-51 pubmed publisher
    Controversial results regarding the association of eNOS gene (NOS3) polymorphisms with myocardial infarction (MI) have been reported...
  11. Szolnoki Z, Havasi V, Bene J, Komlosi K, Szoke D, Somogyvari F, et al. Endothelial nitric oxide synthase gene interactions and the risk of ischaemic stroke. Acta Neurol Scand. 2005;111:29-33 pubmed
    Endothelial nitric oxide synthase (eNOS), which produces NO, plays an important role in the endothelial function under a wide range of physiological conditions...
  12. DeMeo D, Campbell E, Barker A, Brantly M, Eden E, McElvaney N, et al. IL10 polymorphisms are associated with airflow obstruction in severe alpha1-antitrypsin deficiency. Am J Respir Cell Mol Biol. 2008;38:114-20 pubmed
    ..Haplotype analysis of IL10 SNPs suggested the strongest association with IL10 promoter SNPs. IL10 is likely an important modifier gene for the development of COPD in individuals with severe AAT deficiency. ..
  13. Ezzidi I, Mtiraoui N, Mohamed M, Mahjoub T, Kacem M, Almawi W. Endothelial nitric oxide synthase Glu298Asp, 4b/a, and T-786C polymorphisms in type 2 diabetic retinopathy. Clin Endocrinol (Oxf). 2008;68:542-6 pubmed
    The possible association between the endothelial nitric oxide (eNOS) gene T-786C (promoter region), 27-bp repeat 4b/4a (intron 4), and Glu298Asp (exon 7) polymorphisms with diabetic retinopathy (DR) was investigated...
  14. Serrano N, Diaz L, Casas J, Hingorani A, Moreno de Lucca D, Páez M. Frequency of eNOS polymorphisms in the Colombian general population. BMC Genet. 2010;11:54 pubmed publisher
    ..It has been suggested that polymorphisms in endothelial nitric oxide synthase (eNOS) can affect the response of the vascular endothelium to increased oxidative stress...
  15. Buchholz T, Lohse P, Kosian E, Thaler C. Vasoconstrictively acting AT1R A1166C and NOS3 4/5 polymorphisms in recurrent spontaneous abortions (RSA). Am J Reprod Immunol. 2004;51:323-8 pubmed
    ..Vasoconstriction is influenced by the expression of endothelial nitric oxide synthase (eNOS) and of the angiotensinogen II type 1 receptor (AT1R)...
  16. Kobashi G, Ohta K, Yamada H, Hata A, Minakami H, Sakuragi N, et al. 4G/5G variant of plasminogen activator inhibitor-1 gene and severe pregnancy-induced hypertension: subgroup analyses of variants of angiotensinogen and endothelial nitric oxide synthase. J Epidemiol. 2009;19:275-80 pubmed
  17. Wu R, Ma N. Expression of nitric oxide synthase and guanylate cyclase in the human ciliary body and trabecular meshwork. Chin Med J (Engl). 2012;125:129-33 pubmed
    ..This study was designed to investigate the expression and distribution of NO synthase (NOS) isoforms and guanylate cyclase (GC) in human ciliary body, trabecular meshwork and the Schlemm's canal...
  18. Vannemreddy P, Notarianni C, Yanamandra K, Napper D, Bocchini J. Is an endothelial nitric oxide synthase gene mutation a risk factor in the origin of intraventricular hemorrhage?. Neurosurg Focus. 2010;28:E11 pubmed publisher
    Studies have shown decreased levels of nitric oxide (NO), the product of endothelial NO synthase (eNOS) gene activity, in infants with respiratory conditions and intraventricular hemorrhage (IVH)...
  19. Chen L, Huang C, Yeh H, Lee C, Shyu M, Hsieh F, et al. Polymorphisms in the endothelial nitric oxide synthase gene may be protective against preeclampsia in a Chinese population. Reprod Sci. 2007;14:175-81 pubmed
    The association between the endothelial nitric oxide synthase (eNOS) gene with vascular diseases in Western populations and with severe preeclampsia (PE) in the Japanese population have been demonstrated, lacing the data in Chinese ..
  20. Nakayama M, Yasue H, Yoshimura M, Shimasaki Y, Kugiyama K, Ogawa H, et al. T-786-->C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm. Circulation. 1999;99:2864-70 pubmed
    ..We searched for the possible mutations in the endothelial nitric oxide synthase (eNOS) gene in patients with coronary spasm...
  21. Gavin K, Seals D, Silver A, Moreau K. Vascular endothelial estrogen receptor alpha is modulated by estrogen status and related to endothelial function and endothelial nitric oxide synthase in healthy women. J Clin Endocrinol Metab. 2009;94:3513-20 pubmed publisher
    ..Endothelial-dependent dilation (EDD; brachial artery flow-mediated dilation) and endothelial nitric oxide synthase (eNOS) expression and activation were also measured in a subgroup of women...
  22. Jaramillo P, Lanas C, Lanas F, Salazar L. Polymorphisms of the NOS3 gene in Southern Chilean subjects with coronary artery disease and controls. Clin Chim Acta. 2010;411:258-62 pubmed publisher
    ..produced by oxidation of l-arginine to l-citruline for the action at the endothelial nitric oxide synthase (eNOS) is considered an important atheroprotective factor...
  23. Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher A. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature. 1999;399:601-5 pubmed
    Nitric oxide (NO) produced by the endothelial NO synthase (eNOS) is a fundamental determinant of cardiovascular homesotasis: it regulates systemic blood pressure, vascular remodelling and angiogenesis...
  24. Bellini M, Figueira M, Piccoli M, Marumo J, Cendoroglo M, Neto M, et al. Association of endothelial nitric oxide synthase gene intron 4 polymorphism with end-stage renal disease. Nephrology (Carlton). 2007;12:289-93 pubmed
    ..In the endothelial nitric oxide synthase (eNOS) intron 4 polymorphism, the presence of the aa genotype has been associated with cardiovascular and renal disease...
  25. Colombo M, Andreassi M, Paradossi U, Botto N, Manfredi S, Masetti S, et al. Evidence for association of a common variant of the endothelial nitric oxide synthase gene (Glu298-->Asp polymorphism) to the presence, extent, and severity of coronary artery disease. Heart. 2002;87:525-8 pubmed
    Genetic variants of endothelial nitric oxide synthase (eNOS) could influence individual susceptibility to coronary artery disease...
  26. Liao Q, Wang D, Sun H. Association of genetic polymorphisms of eNOS with glaucoma. Mol Vis. 2011;17:153-8 pubmed
    ..In the present study, we aimed to investigate the association of endothelial nitric oxide synthase (eNOS) gene polymorphisms with primary open angle glaucoma (POAG) and primary closed angle glaucoma (PCAG)...
  27. Awata T, Neda T, Iizuka H, Kurihara S, Ohkubo T, Takata N, et al. Endothelial nitric oxide synthase gene is associated with diabetic macular edema in type 2 diabetes. Diabetes Care. 2004;27:2184-90 pubmed
    We examined the endothelial nitric oxide (eNOS) gene polymorphisms to assess its possible association with diabetic retinopathy and macular edema. A total of 226 patients with type 2 diabetes and 186 healthy subjects were studied...
  28. Cam S, Sekuri C, Tengiz I, Ercan E, Sagcan A, Akin M, et al. The G894T polymorphism on endothelial nitric oxide synthase gene is associated with premature coronary artery disease in a Turkish population. Thromb Res. 2005;116:287-92 pubmed
    ..The eNOS gene polymorphism was analysed in 115 (mean age, 48.1+/-7...
  29. Ingelsson E, Syvanen A, Lind L. Endothelium-dependent vasodilation in conduit and resistance vessels in relation to the endothelial nitric oxide synthase gene. J Hum Hypertens. 2008;22:569-78 pubmed publisher
    ..This SNP has previously been related to coronary heart disease, and our findings should stimulate to replication and exploration of the association of NOS3 variation with endothelial function in other settings. ..
  30. Sandrim V, Palei A, Sertorio J, Cavalli R, Duarte G, Tanus Santos J. Effects of eNOS polymorphisms on nitric oxide formation in healthy pregnancy and in pre-eclampsia. Mol Hum Reprod. 2010;16:506-10 pubmed publisher
    ..However, no previous study has examined whether genetic variations in the endothelial NO synthase (eNOS) affect this alteration. We hypothesized that PE decreases NO formation depending on eNOS polymorphisms...
  31. Erbs S, Baither Y, Linke A, Adams V, Shu Y, Lenk K, et al. Promoter but not exon 7 polymorphism of endothelial nitric oxide synthase affects training-induced correction of endothelial dysfunction. Arterioscler Thromb Vasc Biol. 2003;23:1814-9 pubmed
    Background- Polymorphisms in the promoter (T-786C) and exon 7 (G894T) of the endothelial nitric oxide synthase (eNOS) gene were shown to be associated with reduced vascular NO production or increased proteolytic cleavage of eNOS...
  32. Fernandez M, Ruiz R, Gonzalez M, Ramirez Lorca R, Couto C, Ramos A, et al. Association of NOS3 gene with metabolic syndrome in hypertensive patients. Thromb Haemost. 2004;92:413-8 pubmed
    Recent data from animal models indicate that the eNOS null mice present a phenotype that resemble the human metabolic syndrome (hypertension, insulin resistance and hypertriglyceridemia)...
  33. Munshi A, Rajeshwar K, Kaul S, Chandana E, Shafi G, Anila A, et al. VNTR polymorphism in intron 4 of the eNOS gene and the risk of ischemic stroke in a South Indian population. Brain Res Bull. 2010;82:247-50 pubmed publisher
    ..the Variable Number of Tandem Repeats (VNTR) polymorphism in intron 4 of the endothelial nitric oxide synthase (eNOS) gene is associated with ischemic stroke in a South Indian population...
  34. Santos K, Crispim D, Canani L, Ferrugem P, Gross J, Roisenberg I. Association of eNOS gene polymorphisms with renal disease in Caucasians with type 2 diabetes. Diabetes Res Clin Pract. 2011;91:353-62 pubmed publisher
    ..study we investigated if the -786T>C, the VNTR intron 4 a/b and the 894G>T (Glu298Asp) polymorphisms in the eNOS gene were associated with renal disease in 617 type 2 diabetic Caucasian-Brazilians...
  35. Kobashi G, Yamada H, Ohta K, Kato E, Ebina Y, Fujimoto S. Endothelial nitric oxide synthase gene (NOS3) variant and hypertension in pregnancy. Am J Med Genet. 2001;103:241-4 pubmed
    ..The odds ratios of the factors were 2.7, 2.3, 2.2, and 2.1, respectively. Our results suggested that the Asp298 of NOS3 is a potent, independent risk factor for HP. ..
  36. Davis M, Grumbach I, Fukai T, Cutchins A, Harrison D. Shear stress regulates endothelial nitric-oxide synthase promoter activity through nuclear factor kappaB binding. J Biol Chem. 2004;279:163-8 pubmed
    We have previously demonstrated that shear stress increases transcription of the endothelial nitric-oxide synthase (eNOS) by a pathway involving activation of the tyrosine kinase c-Src and extracellular signal-related kinase 1/2 (ERK1/2)...
  37. Khurana V, Meissner I, Sohni Y, Bamlet W, McClelland R, Cunningham J, et al. The presence of tandem endothelial nitric oxide synthase gene polymorphisms identifying brain aneurysms more prone to rupture. J Neurosurg. 2005;102:526-31 pubmed
    ..prone to rupture may be identified on the basis of an individual's genotype for endothelial nitric oxide synthase (eNOS), a critical vasomodulatory protein found to be increasingly relevant to the pathobiology of aneurysms...
  38. Thors B, Halldórsson H, Jónsdóttir G, Thorgeirsson G. Mechanism of thrombin mediated eNOS phosphorylation in endothelial cells is dependent on ATP levels after stimulation. Biochim Biophys Acta. 2008;1783:1893-902 pubmed publisher
    ..the role of AMP-activated protein kinase (AMPK) in mediating thrombin stimulation of endothelial NO-synthase (eNOS)...
  39. Luizon M, Izidoro Toledo T, Simoes A, Tanus Santos J. Endothelial nitric oxide synthase polymorphisms and haplotypes in Amerindians. DNA Cell Biol. 2009;28:329-34 pubmed publisher
    Interethnic disparities in the distribution of endothelial nitric oxide synthase (eNOS) polymorphisms may affect nitric oxide (NO)-mediated effects of and responses to drugs...
  40. Deng F, Hu Q, Tang B, He F, Guo S, Chen J, et al. Endothelial nitric oxide synthase gene intron 4, 27 bp repeat polymorphism and essential hypertension in the Kazakh Chinese population. Acta Biochim Biophys Sin (Shanghai). 2007;39:311-6 pubmed
    ..The polymorphism of eNOS in the two groups was detected with polymerase chain reaction assays and the genotype frequencies in each group ..
  41. Zeng Z, Li L, Zhang Z, Li Y, Wei Z, Huang K, et al. A meta-analysis of three polymorphisms in the endothelial nitric oxide synthase gene (NOS3) and their effect on the risk of diabetic nephropathy. Hum Genet. 2010;127:373-81 pubmed publisher
    ..16, 1.01-1.34, 95% CI) with little heterogeneity. In summary, our meta-analysis of the effect of NOS3 gene polymorphisms on the risk of DN supports the involvement of the NOS3 gene in the pathogenesis of DN. ..
  42. Asakimori Y, Yorioka N, Taniguchi Y, Ito T, Ogata S, Kyuden Y, et al. T(-786)-->C polymorphism of the endothelial nitric oxide synthase gene influences the progression of renal disease. Nephron. 2002;91:747-51 pubmed
    Polymorphism of the endothelial nitric oxide synthase (ecNOS) gene may be involved in renal disease. Recently, T(-786)-->C polymorphism affecting ecNOS gene transcription has been reported...
  43. Logan J, Chakravarthy U, Hughes A, Patterson C, Jackson J, Rankin S. Evidence for association of endothelial nitric oxide synthase gene in subjects with glaucoma and a history of migraine. Invest Ophthalmol Vis Sci. 2005;46:3221-6 pubmed
    ..This study provides evidence of an association between the NOS3 gene and subjects with glaucoma who have a history of migraine. Unlike in other studies, no evidence was found of an association between ET-1 and glaucoma. ..
  44. Marangoni K, Neves A, Cardoso A, Santos W, Faria P, Goulart L. The endothelial nitric oxide synthase Glu-298-Asp polymorphism and its mRNA expression in the peripheral blood of patients with prostate cancer and benign prostatic hyperplasia. Cancer Detect Prev. 2006;30:7-13 pubmed
    The endothelial nitric oxide synthase (ecNOS) has an important role in vascular development and in the carcinogenesis process of prostate cancer (PCa)...
  45. Kim I, Bae J, Lim S, Cha D, Cho H, Kim S, et al. Influence of endothelial nitric oxide synthase gene polymorphisms (-786T>C, 4a4b, 894G>T) in Korean patients with coronary artery disease. Thromb Res. 2007;119:579-85 pubmed
    Endothelium-derived nitric oxide (NO) is synthesized from l-arginine by endothelial nitric oxide synthase (eNOS) encoded by the eNOS3 gene on chromosome 7...
  46. Agirbasli M, Guney A, Ozturhan H, Agirbasli D, Ulucan K, Sevinc D, et al. Multifactor dimensionality reduction analysis of MTHFR, PAI-1, ACE, PON1, and eNOS gene polymorphisms in patients with early onset coronary artery disease. Eur J Cardiovasc Prev Rehabil. 2011;18:803-9 pubmed publisher
    ..tetrahydrofolate reductase C677T, plasminogen activator inhibitor 4G/5G, endothelial nitric oxide synthase (eNOS) 3-27 base pair repeat, insertion, or deletion of a 287 bp Alu repeat sequence polymorhism of angiotensin I ..
  47. Weiss J, Haefeli W, Gasse C, Hoffmann M, Weyman J, Gibbs S, et al. Lack of evidence for association of high altitude pulmonary edema and polymorphisms of the NO pathway. High Alt Med Biol. 2003;4:355-66 pubmed
    ..The results of this study suggest that none of these genetic variants plays a substantial role in the pathogenesis of HAPE in Caucasians, but does not exclude epistatic effects that might still involve the genetic systems studied here. ..
  48. Uthra S, Raman R, Mukesh B, Padmaja Kumari R, Paul P, Lakshmipathy P, et al. Intron 4 VNTR of endothelial nitric oxide synthase (eNOS) gene and diabetic retinopathy in type 2 patients in southern India. Ophthalmic Genet. 2007;28:77-81 pubmed
    A 27-bp variable number tandem repeat (VNTR) in intron 4 of endothelial nitric oxide synthase (eNOS) gene has been associated with the risk for developing diabetic retinopathy (DR) in various ethnic populations...
  49. Schneider M, Erdmann J, Delles C, Fleck E, Regitz Zagrosek V, Schmieder R. Functional gene testing of the Glu298Asp polymorphism of the endothelial NO synthase. J Hypertens. 2000;18:1767-73 pubmed
    To test whether the Glu298Asp polymorphism of the endothelial nitric oxide synthase (eNOS) gene is of functional relevance in humans by altering endothelium-dependent vasodilation...
  50. Khurana V, Sohni Y, Mangrum W, McClelland R, O Kane D, Meyer F, et al. Endothelial nitric oxide synthase gene polymorphisms predict susceptibility to aneurysmal subarachnoid hemorrhage and cerebral vasospasm. J Cereb Blood Flow Metab. 2004;24:291-7 pubmed
    ..In humans, the gene encoding the endothelial isoform of nitric oxide synthase (eNOS) is known to be polymorphic, with certain polymorphisms associated with increased cardiovascular disease ..
  51. Serrano N, Casas J, Diaz L, Páez C, Mesa C, Cifuentes R, et al. Endothelial NO synthase genotype and risk of preeclampsia: a multicenter case-control study. Hypertension. 2004;44:702-7 pubmed
    Polymorphisms in the endothelial NO synthase (eNOS) gene have been evaluated as risk factors for preeclampsia. However, data from small studies are conflicting...
  52. Rippin J, Patel A, Belyaev N, Gill G, Barnett A, Bain S. Nitric oxide synthase gene polymorphisms and diabetic nephropathy. Diabetologia. 2003;46:426-8 pubmed
    ..The previous suggestion from smaller studies that the intron 4 polymorphism in NOS3 could play a role in susceptibility to the disease is not confirmed. ..
  53. Yoshimura T, Chowdhury F, Yoshimura M, Okamura H. Genetic and environmental contributions to severe preeclampsia: lack of association with the endothelial nitric oxide synthase Glu298Asp variant in a developing country. Gynecol Obstet Invest. 2003;56:10-3 pubmed
    We recently identified a missense variant (Glu298Asp) within exon 7 of the endothelial nitric oxide synthase (eNOS) gene that is associated with severe preeclampsia in the Japanese population...
  54. Chrysohoou C, Panagiotakos D, Pitsavos C, Antoniades C, Skoumas J, Brown M, et al. Evidence for association between endothelial nitric oxide synthase gene polymorphism (G894T) and inflammatory markers: the ATTICA study. Am Heart J. 2004;148:733-8 pubmed
    ..point mutation of guanine to thymine at nucleotide position 894 (G894T) of the endothelial nitric oxide synthase (eNOS) gene on inflammatory and oxidative stress markers...
  55. Taverna M, Elgrably F, Selmi H, Selam J, Slama G. The T-786C and C774T endothelial nitric oxide synthase gene polymorphisms independently affect the onset pattern of severe diabetic retinopathy. Nitric Oxide. 2005;13:88-92 pubmed
    ..Recently, we reported a strong association between the eNOS4b/a endothelial nitric oxide synthase (eNOS) polymorphism and severe DR...
  56. Djuric T, Zivkovic M, Stankovic A, Mecanin S, Alavantic D. Endothelial NOS G894 T and MMP-3 5A/6A gene polymorphisms and hypertension in Serbian population. J Clin Lab Anal. 2005;19:241-6 pubmed
    ..associated with artery stiffening and elevated blood pressure, whereas results considering association of endothelial NOS (eNOS) G894 T polymorphism with hypertension are controversial...
  57. Rios D, D Onofrio L, Souza J, Queiroz A, Raduy Maron L, Silva Neto N, et al. Smoking-dependent and haplotype-specific effects of endothelial nitric oxide synthase gene polymorphisms on angiographically assessed coronary artery disease in Caucasian- and African-Brazilians. Atherosclerosis. 2007;193:135-41 pubmed
    The nitric oxide produced by endothelial nitric oxide synthase (eNOS) plays a pivotal role in protecting the arterial wall from damages and atherosclerosis...
  58. Vimaleswaran K, Franks P, Barroso I, Brage S, Ekelund U, Wareham N, et al. Habitual energy expenditure modifies the association between NOS3 gene polymorphisms and blood pressure. Am J Hypertens. 2008;21:297-302 pubmed publisher
    The endothelial nitric-oxide synthase (NOS3) gene encodes the enzyme (eNOS) that synthesizes the molecule nitric oxide, which facilitates endothelium-dependent vasodilation in response to physical activity...
  59. Yildiz P, Oflaz H, Cine N, Erginel Unaltuna N, Erzengin F, Yilmaz V. Gene polymorphisms of endothelial nitric oxide synthase enzyme associated with pulmonary hypertension in patients with COPD. Respir Med. 2003;97:1282-8 pubmed
    ..the role of polymorphisms of the angiotensin-converting enzyme (ACE) and endothelial nitric oxide synthase (eNOS) genes on pulmonary hypertension (PH) in patients with chronic obstructive pulmonary disease (COPD)...
  60. Li R, Lyn D, Lapu Bula R, Oduwole A, Igho Pemu P, Lankford B, et al. Relation of endothelial nitric oxide synthase gene to plasma nitric oxide level, endothelial function, and blood pressure in African Americans. Am J Hypertens. 2004;17:560-7 pubmed
    The role of eNOS gene polymorphisms on plasma nitrite or nitrate (NOx) level, endothelial function, and blood pressure (BP) remains unclear...
  61. Salimi S, Firoozrai M, Zand H, Nakhaee A, Shafiee S, Tavilani H, et al. Endothelial nitric oxide synthase gene Glu298Asp polymorphism in patients with coronary artery disease. Ann Saudi Med. 2010;30:33-7 pubmed publisher
    ..These results suggest that CAD is associated with Glu298Asp polymorphism of the NOS3 gene in our population and that this polymorphism is an independent risk factor for CAD. ..
  62. Niu W, Qi Y. An updated meta-analysis of endothelial nitric oxide synthase gene: three well-characterized polymorphisms with hypertension. PLoS ONE. 2011;6:e24266 pubmed publisher
    Numerous individually underpowered association studies have been conducted on endothelial nitric oxide synthase (eNOS) genetic variants across different ethnic populations, however, the results are often irreproducible...
  63. Suzuki H, Nagase S, Kikuchi S, Wang Y, Koyama A. Association of a missense Glu298Asp mutation of the endothelial nitric oxide synthase gene with end stage renal disease. Clin Chem. 2000;46:1858-60 pubmed
  64. Casas J, Bautista L, Humphries S, Hingorani A. Endothelial nitric oxide synthase genotype and ischemic heart disease: meta-analysis of 26 studies involving 23028 subjects. Circulation. 2004;109:1359-65 pubmed
    Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene may influence the risk of ischemic heart disease (IHD), but data from published studies with individually low statistical power are conflicting...
  65. Rashid G, Bernheim J, Green J, Benchetrit S. Parathyroid hormone stimulates the endothelial nitric oxide synthase through protein kinase A and C pathways. Nephrol Dial Transplant. 2007;22:2831-7 pubmed
    ..production of nitric oxide, and acute PTH effect is characterized by vasodilation, the effect of PTH on the endothelial NOS (eNOS) system was measured in cultured human umbilical cord vein endothelial cells (HUVEC) and the pathways ..
  66. Jemaa R, Ben Ali S, Kallel A, Feki M, Elasmi M, Taieb S, et al. Association of a 27-bp repeat polymorphism in intron 4 of endothelial constitutive nitric oxide synthase gene with hypertension in a Tunisian population. Clin Biochem. 2009;42:852-6 pubmed publisher
    Nitric oxide (NO) produced by endothelial nitric oxide synthase (eNOS) mediates endothelium-dependent vasodilatation and antithrombotic action...
  67. Aoyagi M, Arvai A, Tainer J, Getzoff E. Structural basis for endothelial nitric oxide synthase binding to calmodulin. EMBO J. 2003;22:766-75 pubmed
    ..Here, the crystallographic structure of Ca(2+)-loaded CaM bound to a 20 residue peptide comprising the endothelial NOS (eNOS) CaM-binding region establishes their individual conformations and intermolecular interactions, and ..
  68. Heltianu C, Costache G, Gafencu A, Diaconu M, Bodeanu M, Cristea C, et al. Relationship of eNOS gene variants to diseases that have in common an endothelial cell dysfunction. J Cell Mol Med. 2005;9:135-42 pubmed
    ..Aware of the role of eNO and ACE in EC dysfunction, we questioned whether polymorphism of eNOS and/or ACE gene may be a common denominator in these pathologies...
  69. Sampaio M, Hirata M, Hirata R, Santos F, Picciotti R, Luchessi A, et al. AMI is associated with polymorphisms in the NOS3 and FGB but not in PAI-1 genes in young adults. Clin Chim Acta. 2007;377:154-62 pubmed
    ..018) than the other haplotypes. Our data suggest NOS3 and FGB polymorphisms are associated with AMI. NOS3 is also related to hypertension, endothelial dysfunction and variation on serum cholesterol in young adults with AMI. ..
  70. Brouet A, Sonveaux P, Dessy C, Balligand J, Feron O. Hsp90 ensures the transition from the early Ca2+-dependent to the late phosphorylation-dependent activation of the endothelial nitric-oxide synthase in vascular endothelial growth factor-exposed endothelial cells. J Biol Chem. 2001;276:32663-9 pubmed
    ..factor (VEGF) exerts its angiogenic effects partly through the activation of endothelial nitric-oxide synthase (eNOS)...