ENO1

Summary

Gene Symbol: ENO1
Description: enolase 1
Alias: ENO1L1, HEL-S-17, MPB1, NNE, PPH, alpha-enolase, c-myc promoter-binding protein-1, 2-phospho-D-glycerate hydro-lyase, MYC promoter-binding protein 1, alpha enolase like 1, enolase 1, (alpha), enolase-alpha, epididymis secretory protein Li 17, non-neural enolase, phosphopyruvate hydratase, plasminogen-binding protein, tau-crystallin
Species: human
Products:     ENO1

Top Publications

  1. Perconti G, Ferro A, Amato F, Rubino P, Randazzo D, Wolff T, et al. The kelch protein NS1-BP interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. Biochim Biophys Acta. 2007;1773:1774-85 pubmed
    ..These findings further support the distinct roles of alpha-enolase and its MBP-1 variant in maintaining cell homeostasis. Moreover, our data suggest a novel function for NS1-BP in the control of cell proliferation. ..
  2. White R, Adkison L, Dowler L, Ray R. Chromosomal localization of the human gene encoding c-myc promoter-binding protein (MPB1) to chromosome 1p35-pter. Genomics. 1997;39:406-8 pubmed
    We report the mapping of the human gene MPB1 (c-myc promoter binding protein), a recently identified gene regulatory protein. MPB1 binds to the c-myc P2 promoter and exerts a negative regulatory role on c-myc transcription...
  3. Castegna A, Thongboonkerd V, Klein J, Lynn B, Markesbery W, Butterfield D. Proteomic identification of nitrated proteins in Alzheimer's disease brain. J Neurochem. 2003;85:1394-401 pubmed
    ....
  4. Subramanian A, Miller D. Structural analysis of alpha-enolase. Mapping the functional domains involved in down-regulation of the c-myc protooncogene. J Biol Chem. 2000;275:5958-65 pubmed
    ..Our data suggest that alpha-enolase plays an important role in regulation of c-myc promoter activity in the form of an alternative translation product MBP-1, which is distinct from its role as a glycolytic enzyme. ..
  5. Castegna A, Aksenov M, Thongboonkerd V, Klein J, Pierce W, Booze R, et al. Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: dihydropyrimidinase-related protein 2, alpha-enolase and heat shock cognate 71. J Neurochem. 2002;82:1524-32 pubmed
    ..These results are discussed with reference to potential involvement of these oxidatively modified proteins in neurodegeneration in AD brain. ..
  6. Zhang Y, Li M, Liu Y, Han N, Zhang K, Xiao T, et al. [ENO1 protein levels in the tumor tissues and circulating plasma samples of non-small cell lung cancer patients]. Zhongguo Fei Ai Za Zhi. 2010;13:1089-93 pubmed publisher
    ..The aim of this study is to examine the levels of alpha-enolase (ENO1) protein in the tumor tissues and peripheral plasma samples obtained from non-small cell lung cancer (NSCLC) ..
  7. Cappello P, Tomaino B, Chiarle R, Ceruti P, Novarino A, Castagnoli C, et al. An integrated humoral and cellular response is elicited in pancreatic cancer by alpha-enolase, a novel pancreatic ductal adenocarcinoma-associated antigen. Int J Cancer. 2009;125:639-48 pubmed publisher
    ..It is thus a promising and clinically relevant molecular target candidate for immunotherapeutic approaches as new adjuvants to conventional treatments in pancreatic cancer...
  8. Jeyabalan J, Nesbit M, Galvanovskis J, Callaghan R, Rorsman P, Thakker R. SEDLIN forms homodimers: characterisation of SEDLIN mutations and their interactions with transcription factors MBP1, PITX1 and SF1. PLoS ONE. 2010;5:e10646 pubmed publisher
    ..Our studies demonstrate that SEDLIN is present in the nucleus, forms homodimers and that SEDT-associated mutations cause a loss of interaction with the transcription factors MBP1, PITX1 and SF1. ..
  9. Ghosh A, Majumder M, Steele R, White R, Ray R. A novel 16-kilodalton cellular protein physically interacts with and antagonizes the functional activity of c-myc promoter-binding protein 1. Mol Cell Biol. 2001;21:655-62 pubmed
    ..Additionally, MIP-2A antagonizes cell growth regulatory role of MBP-1. Taken together, these results suggest the functional interaction of MIP-2A and MBP-1 in cell growth regulation. ..
  10. Muller F, Colla S, Aquilanti E, Manzo V, Genovese G, Lee J, et al. Passenger deletions generate therapeutic vulnerabilities in cancer. Nature. 2012;488:337-42 pubmed publisher
    ..The glycolytic gene enolase 1 (ENO1) in the 1p36 locus is deleted in glioblastoma (GBM), which is tolerated by the expression of ENO2...

Detail Information

Publications62

  1. Perconti G, Ferro A, Amato F, Rubino P, Randazzo D, Wolff T, et al. The kelch protein NS1-BP interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. Biochim Biophys Acta. 2007;1773:1774-85 pubmed
    ..These findings further support the distinct roles of alpha-enolase and its MBP-1 variant in maintaining cell homeostasis. Moreover, our data suggest a novel function for NS1-BP in the control of cell proliferation. ..
  2. White R, Adkison L, Dowler L, Ray R. Chromosomal localization of the human gene encoding c-myc promoter-binding protein (MPB1) to chromosome 1p35-pter. Genomics. 1997;39:406-8 pubmed
    We report the mapping of the human gene MPB1 (c-myc promoter binding protein), a recently identified gene regulatory protein. MPB1 binds to the c-myc P2 promoter and exerts a negative regulatory role on c-myc transcription...
  3. Castegna A, Thongboonkerd V, Klein J, Lynn B, Markesbery W, Butterfield D. Proteomic identification of nitrated proteins in Alzheimer's disease brain. J Neurochem. 2003;85:1394-401 pubmed
    ....
  4. Subramanian A, Miller D. Structural analysis of alpha-enolase. Mapping the functional domains involved in down-regulation of the c-myc protooncogene. J Biol Chem. 2000;275:5958-65 pubmed
    ..Our data suggest that alpha-enolase plays an important role in regulation of c-myc promoter activity in the form of an alternative translation product MBP-1, which is distinct from its role as a glycolytic enzyme. ..
  5. Castegna A, Aksenov M, Thongboonkerd V, Klein J, Pierce W, Booze R, et al. Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: dihydropyrimidinase-related protein 2, alpha-enolase and heat shock cognate 71. J Neurochem. 2002;82:1524-32 pubmed
    ..These results are discussed with reference to potential involvement of these oxidatively modified proteins in neurodegeneration in AD brain. ..
  6. Zhang Y, Li M, Liu Y, Han N, Zhang K, Xiao T, et al. [ENO1 protein levels in the tumor tissues and circulating plasma samples of non-small cell lung cancer patients]. Zhongguo Fei Ai Za Zhi. 2010;13:1089-93 pubmed publisher
    ..The aim of this study is to examine the levels of alpha-enolase (ENO1) protein in the tumor tissues and peripheral plasma samples obtained from non-small cell lung cancer (NSCLC) ..
  7. Cappello P, Tomaino B, Chiarle R, Ceruti P, Novarino A, Castagnoli C, et al. An integrated humoral and cellular response is elicited in pancreatic cancer by alpha-enolase, a novel pancreatic ductal adenocarcinoma-associated antigen. Int J Cancer. 2009;125:639-48 pubmed publisher
    ..It is thus a promising and clinically relevant molecular target candidate for immunotherapeutic approaches as new adjuvants to conventional treatments in pancreatic cancer...
  8. Jeyabalan J, Nesbit M, Galvanovskis J, Callaghan R, Rorsman P, Thakker R. SEDLIN forms homodimers: characterisation of SEDLIN mutations and their interactions with transcription factors MBP1, PITX1 and SF1. PLoS ONE. 2010;5:e10646 pubmed publisher
    ..Our studies demonstrate that SEDLIN is present in the nucleus, forms homodimers and that SEDT-associated mutations cause a loss of interaction with the transcription factors MBP1, PITX1 and SF1. ..
  9. Ghosh A, Majumder M, Steele R, White R, Ray R. A novel 16-kilodalton cellular protein physically interacts with and antagonizes the functional activity of c-myc promoter-binding protein 1. Mol Cell Biol. 2001;21:655-62 pubmed
    ..Additionally, MIP-2A antagonizes cell growth regulatory role of MBP-1. Taken together, these results suggest the functional interaction of MIP-2A and MBP-1 in cell growth regulation. ..
  10. Muller F, Colla S, Aquilanti E, Manzo V, Genovese G, Lee J, et al. Passenger deletions generate therapeutic vulnerabilities in cancer. Nature. 2012;488:337-42 pubmed publisher
    ..The glycolytic gene enolase 1 (ENO1) in the 1p36 locus is deleted in glioblastoma (GBM), which is tolerated by the expression of ENO2...
  11. Hsiao K, Shih N, Fang H, Huang T, Kuo C, Chu P, et al. Surface α-enolase promotes extracellular matrix degradation and tumor metastasis and represents a new therapeutic target. PLoS ONE. 2013;8:e69354 pubmed publisher
    ..This study demonstrated that surface α-enolase promotes extracellular matrix degradation and invasion of cancer cells and that targeting surface α-enolase is a promising approach to suppress tumor metastasis. ..
  12. Ray R, Miller D. Cloning and characterization of a human c-myc promoter-binding protein. Mol Cell Biol. 1991;11:2154-61 pubmed
    ..Coexpression of the MBP-1 protein repress transcription from the human c-myc promoter, suggesting that MBP-1 may act as a negative regulatory factor for the human c-myc gene. ..
  13. Jang B, Jeon Y, Choi J, Park M, Kim J, Ishigami A, et al. Peptidylarginine deiminase modulates the physiological roles of enolase via citrullination: links between altered multifunction of enolase and neurodegenerative diseases. Biochem J. 2012;445:183-92 pubmed publisher
    ..In the present study, we report that citrullination diversely regulates the biological functions of ENO1 (α-enolase) and NSE (neuron-specific enolase)...
  14. Oliva D, Cali L, Feo S, Giallongo A. Complete structure of the human gene encoding neuron-specific enolase. Genomics. 1991;10:157-65 pubmed
    ..A comparison of the 5'-flanking region of the human gamma-enolase gene with the same region of the rat gene revealed a high degree of sequence conservation. ..
  15. Yonglitthipagon P, Pairojkul C, Bhudhisawasdi V, Mulvenna J, Loukas A, Sripa B. Proteomics-based identification of α-enolase as a potential prognostic marker in cholangiocarcinoma. Clin Biochem. 2012;45:827-34 pubmed publisher
    To investigate the association of expression status of α-enolase (ENO1) and clinicopathological outcomes of CCA patients...
  16. Bae S, Kim H, Lee N, Won C, Kim H, Hwang Y, et al. α-Enolase expressed on the surfaces of monocytes and macrophages induces robust synovial inflammation in rheumatoid arthritis. J Immunol. 2012;189:365-72 pubmed publisher
    Enolase (ENO1) is a multifunctional glycolytic enzyme expressed abundantly in the cytosol. It has been implicated in autoimmune and inflammatory diseases. Serum Abs against ENO1 were reported in rheumatoid arthritis (RA)...
  17. Tsai S, Chien I, SHEN W, Kuo Y, Jin Y, Wong T, et al. ENO1, a potential prognostic head and neck cancer marker, promotes transformation partly via chemokine CCL20 induction. Eur J Cancer. 2010;46:1712-23 pubmed publisher
    ..report aims to study the prognostic implication, and determine the cellular role and action mechanism of glycolytic ENO1 overexpression in head and neck cancer...
  18. Beckner M, Fellows Mayle W, Zhang Z, Agostino N, Kant J, Day B, et al. Identification of ATP citrate lyase as a positive regulator of glycolytic function in glioblastomas. Int J Cancer. 2010;126:2282-95 pubmed publisher
    ..prompted investigation of ACLY gene expression in gliomas for survival data and correlation with expression of ENO1, that encodes enolase 1...
  19. Wygrecka M, Marsh L, Morty R, Henneke I, Guenther A, Lohmeyer J, et al. Enolase-1 promotes plasminogen-mediated recruitment of monocytes to the acutely inflamed lung. Blood. 2009;113:5588-98 pubmed publisher
    ..These data suggest an important mechanism of inflammatory cell invasion mediated by increased cell-surface expression of ENO-1. ..
  20. Hsu K, Hsieh R, Lee Y, Chao C, Wu K, Tseng M, et al. The activated Notch1 receptor cooperates with alpha-enolase and MBP-1 in modulating c-myc activity. Mol Cell Biol. 2008;28:4829-42 pubmed publisher
    ..Here we demonstrated that N1IC interacted with the c-Myc-regulating proteins alpha-enolase and c-myc promoter binding protein 1 (MBP-1)...
  21. Ghosh A, Steele R, Ray R. MBP-1 physically associates with histone deacetylase for transcriptional repression. Biochem Biophys Res Commun. 1999;260:405-9 pubmed
    ....
  22. Ejeskär K, Krona C, Caren H, Zaibak F, Li L, Martinsson T, et al. Introduction of in vitro transcribed ENO1 mRNA into neuroblastoma cells induces cell death. BMC Cancer. 2005;5:161 pubmed
    ..One common genetic feature in aggressive tumours is 1p-deletion. The alpha-enolase (ENO1) gene is located in chromosome region 1p36.2, within the common region of deletion in neuroblastoma...
  23. Moscato S, Pratesi F, Sabbatini A, Chimenti D, Scavuzzo M, Passatino R, et al. Surface expression of a glycolytic enzyme, alpha-enolase, recognized by autoantibodies in connective tissue disorders. Eur J Immunol. 2000;30:3575-84 pubmed
    ..Autoantibodies specific for alpha-enolase could play a pathogenic role, either by a cytopathic effect or by interfering with membrane fibrinolytic activity. ..
  24. Pancholi V. Multifunctional alpha-enolase: its role in diseases. Cell Mol Life Sci. 2001;58:902-20 pubmed
    ....
  25. Lopez Alemany R, Longstaff C, Hawley S, Mirshahi M, Fábregas P, Jardi M, et al. Inhibition of cell surface mediated plasminogen activation by a monoclonal antibody against alpha-Enolase. Am J Hematol. 2003;72:234-42 pubmed
    ..These data suggest that, although leukocytic cells display several molecules that bind plasminogen, alpha-enolase is responsible for the majority of the promotion of plasminogen activation on the surfaces of leukocytic cells. ..
  26. Ito S, Honma T, Ishida K, Wada N, Sasaoka S, Hosoda M, et al. Differential expression of the human alpha-enolase gene in oral epithelium and squamous cell carcinoma. Cancer Sci. 2007;98:499-505 pubmed
    alpha-Enolase and c-myc promoter binding protein 1 are encoded by a single gene, ENO1, and are synthesized from the same transcript through alternative use of translational start sites...
  27. Giallongo A, Oliva D, Cali L, Barba G, Barbieri G, Feo S. Structure of the human gene for alpha-enolase. Eur J Biochem. 1990;190:567-73 pubmed
    ..Furthermore, various sequences similar to known regulatory elements were detected. ..
  28. Feo S, Arcuri D, Piddini E, Passantino R, Giallongo A. ENO1 gene product binds to the c-myc promoter and acts as a transcriptional repressor: relationship with Myc promoter-binding protein 1 (MBP-1). FEBS Lett. 2000;473:47-52 pubmed
    ..The finding that a transcriptional repressor of the c-myc oncogene is an alternatively translated product of the ENO1 gene, which maps to a region of human chromosome 1 frequently deleted in human cancers, makes ENO1 a potential ..
  29. Newman S, Sultana R, Perluigi M, Coccia R, Cai J, Pierce W, et al. An increase in S-glutathionylated proteins in the Alzheimer's disease inferior parietal lobule, a proteomics approach. J Neurosci Res. 2007;85:1506-14 pubmed
    ..This study demonstrates that specific proteins are sensitive to S-glutathionylation, which most likely is due to their sensitivity to cysteine oxidation initiated by the increase in oxidative stress in the AD brain. ..
  30. Hsu K, Hsieh R, Wu C, Chi C, Lee Y, Kuo M, et al. MBP-1 suppresses growth and metastasis of gastric cancer cells through COX-2. Mol Biol Cell. 2009;20:5127-37 pubmed publisher
    The c-Myc promoter binding protein 1 (MBP-1) is a transcriptional suppressor of c-myc expression and involved in control of tumorigenesis. Gastric cancer is one of the most frequent neoplasms and lethal malignancies worldwide...
  31. Ghosh A, Steele R, Ray R. c-myc Promoter-binding protein 1 (MBP-1) regulates prostate cancer cell growth by inhibiting MAPK pathway. J Biol Chem. 2005;280:14325-30 pubmed
    ..Together, our results suggested a novel role of MBP-1 for suppression of prostate cancer cell growth by regulating the MEK5-mediated signaling pathway. ..
  32. Ghosh A, Steele R, Ray R. Knockdown of MBP-1 in human prostate cancer cells delays cell cycle progression. J Biol Chem. 2006;281:23652-7 pubmed
    ..2 cells restored cyclin A and cyclin B1 expression. Together, these results suggest that knockdown of MBP-1 in prostate cancer cells perturbs cell proliferation by inhibiting cyclin A and cyclin B1 expression. ..
  33. Arza B, Felez J, Lopez Alemany R, Miles L, Munoz Canoves P. Identification of an epitope of alpha-enolase (a candidate plasminogen receptor) by phage display. Thromb Haemost. 1997;78:1097-103 pubmed
    ..These data indicate that this sequence contains the epitope recognized by mAB 9C12 and is, therefore, exposed on the cell surface, further suggesting that alpha-enolase and alpha-ERM share common amino acid sequences. ..
  34. Price S, Pangloli P, Dia V. Pepsin-pancreatin hydrolysis reduced the ability of lunasin-enriched material to inhibit activation of the inflammasomes in THP-1 human macrophages. Food Funct. 2017;: pubmed publisher
    ..The objective of this work was to determine the effect of pepsin-pancreatin hydrolysis (PPH) on the ability of lunasin-enriched preparation (LEP) to inhibit inflammasome activation in differentiated THP-1 ..
  35. Safaei A, Rezaei Tavirani M, Zamanian Azodi M, Lashay A, Mohammadi S, Ghasemi Broumand M, et al. Diabetic Retinopathy and Laser Therapy in Rats: A Protein-Protein Interaction Network Analysis. J Lasers Med Sci. 2017;8:S20-S21 pubmed publisher
    ..and cluster screening identified hub-bottelneck genes, including Aldoa, HSPD1, Pgam2, Mapk3, SLC2A4, Ctnnb1, Ywhab, HSPA8, GAPDH and Actb for DR rats versus healthy control and ENO1, Aldoa, GAPDH for DR samples after laser therapy.
  36. Arce P, Vera C, Escudero D, Guerrero J, Lappin A, Oliver A, et al. Structural diversity in Cu(i) complexes of the PNP ligand: from pincer to binuclear coordination modes and their effects upon the electrochemical and photophysical properties. Dalton Trans. 2017;46:13432-13445 pubmed publisher
    ..of the uncoordinated phosphorus atoms in (1), reaction with a second Cu(i) atom bearing secondary ligands (PPh3, phen or dmp) allows the formation of new complexes: a bimetallic helicate [Cu(PNP)2(phen)]<..
  37. Ganguly S, Renz D, Giles L, Gagnon K, McCormick L, Conradie J, et al. Cobalt- and Rhodium-Corrole-Triphenylphosphine Complexes Revisited: The Question of a Noninnocent Corrole. Inorg Chem. 2017;: pubmed publisher
    ..X-ray absorption spectroscopic studies showed that the Co K rising edge of Co[TPC](PPh3) (TPC = triphenylcorrole) is red-shifted by ∼1...
  38. Nishi T, Tsukuda T, Nishikawa M, Tsubomura T. Crystal structure of [N,N-bis-(di-phenyl-phospho-ro-thio-yl)amidato-κ2S,S']bis-(tri-phenyl-phosphane-κP)copper(I) di-chloro-methane monosolvate. Acta Crystallogr E Crystallogr Commun. 2017;73:1105-1107 pubmed publisher
    ..or [Cu(dppaS2)(PPh3)2]·CH2Cl2, is a neutral mononuclear copper(I) complex bearing an N<..
  39. Emerson King J, Knighton R, Gyton M, Chaplin A. Rotaxane synthesis exploiting the M(i)/M(iii) redox couple. Dalton Trans. 2017;46:11645-11655 pubmed publisher
    ..and iridium(iii) through hydrogenation of readily accessible rhodium(i) and iridium(i) complexes [M(COD)(PPh3)2][BArF4] (M = Rh, 2a; Ir, 2b) and reaction with a bipyridyl ..
  40. Sanchez T, Zhang G, Li J, Dai L, Mirshahidi S, Wall N, et al. Immunoseroproteomic Profiling in African American Men with Prostate Cancer: Evidence for an Autoantibody Response to Glycolysis and Plasminogen-Associated Proteins. Mol Cell Proteomics. 2016;15:3564-3580 pubmed
    ..a number of proteins associated with both the glycolysis and plasminogen pathways, particularly to alpha-enolase (ENO1). The proteomic data is deposited in ProteomeXchange with identifier PXD003968...
  41. Nadisauskiene R, Dobozinskas P, Kacerauskiene J, Kliucinskas M, Zhumagali I, Kokenova M, et al. The impact of the implementation of the postpartum haemorrhage management guidelines at the first regional perinatal centre in Southern Kazakhstan. BMC Pregnancy Childbirth. 2016;16:238 pubmed publisher
    Postpartum haemorrhage (PPH) remains one of the most common causes of maternal morbidity and mortality. Therefore, clearly written PPH management guidelines should be used in clinical practice...
  42. Afshar K, Werner M, Tse Y, Glotzer M, GONCZY P. Regulation of cortical contractility and spindle positioning by the protein phosphatase 6 PPH-6 in one-cell stage C. elegans embryos. Development. 2010;137:237-47 pubmed publisher
    ..Here, we characterize the requirements for protein phosphatase PPH-6 and its associated subunit SAPS-1 in one-cell stage C. elegans embryos...
  43. Lung J, Liu K, Chang J, Leu S, Shih N. MBP-1 is efficiently encoded by an alternative transcript of the ENO1 gene but post-translationally regulated by proteasome-dependent protein turnover. FEBS J. 2010;277:4308-21 pubmed publisher
    ..suppressor of tumorigenesis and thought to be the product of alternative translation initiation of the α-enolase (ENO1) transcript...
  44. Bottermann K, Reinartz M, Barsoum M, Kötter S, Gödecke A. Systematic Analysis Reveals Elongation Factor 2 and α-Enolase as Novel Interaction Partners of AKT2. PLoS ONE. 2013;8:e66045 pubmed publisher
    ..Taken together, these findings point to new aspects of AKT2-mediated signal transduction in protein synthesis and glucose metabolism. ..
  45. Chhetri S, Gautam R. Acoustic Analysis Before and After Voice Therapy for Laryngeal Pathology. Kathmandu Univ Med J (KUMJ). 2015;13:323-7 pubmed
    ..including fundamental frequency, jitters, shimmers, Harmonic to noise ratio (HNR), Normalized noise energy (NNE) were analyzed before and after voice therapy...
  46. Zhao S, Wang L, Liu Y, Chen L, Xie Z. Stereochemically Dependent Synthesis of Two Cu(I) Cluster-Based Coordination Polymers with Thermochromic Luminescence. Inorg Chem. 2017;56:13975-13981 pubmed publisher
    ..and trans-1,2-bis(4-(pyridin-2-yl)phenyl)ethane (cis- and trans-bpype) ligands and {Cu4I4(PPh3)4} as starting materials...
  47. Sæmundsson Þ, Morino C, Helgason J, Conway S, Pétursson H. The triggering factors of the Móafellshyrna debris slide in northern Iceland: Intense precipitation, earthquake activity and thawing of mountain permafrost. Sci Total Environ. 2017;: pubmed publisher
    ..Furthermore, the slide occurred after three seismic episodes, whose epicentres were located ~60km NNE of Móafellshyrna Mountain...
  48. Yu X, Yang S, Zhang Y, Guo M, Yamamoto Y, Bao M. Intermolecular Amidation of Quinoline N-Oxides with Arylsulfonamides under Metal-Free Conditions. Org Lett. 2017;19:6088-6091 pubmed publisher
    ..The intermolecular amidation of quinoline N-oxides with sulfonamides proceeded smoothly in the presence of PhI(OAc)2 and PPh3 to afford N-(quinolin-2-yl)sulfonamides in satisfactory to excellent yields.
  49. Chang Y, Wu M, Lin J, Sheu B, Muta T, Inoue H, et al. Induction of cyclooxygenase-2 overexpression in human gastric epithelial cells by Helicobacter pylori involves TLR2/TLR9 and c-Src-dependent nuclear factor-kappaB activation. Mol Pharmacol. 2004;66:1465-77 pubmed
    ..The COX-2 overexpression may contribute to the carcinogenesis in patients colonized with these strains. ..
  50. Zhou W, Cao G, Shen G, Zhu X, Gui Y, Ye J, et al. Visible-Light-Driven Palladium-Catalyzed Radical Alkylation of C-H Bonds with Unactivated Alkyl Bromides. Angew Chem Int Ed Engl. 2017;: pubmed publisher
    Reported herein is a novel visible-light photoredox system with Pd(PPh3 )4 as the sole catalyst for the realization of the first direct cross-coupling of C(sp3 )-H bonds in N-aryl tetrahydroisoquinolines ..
  51. Collins P, Cannings John R, Bruynseels D, Mallaiah S, Dick J, Elton C, et al. Viscoelastometric-guided early fibrinogen concentrate replacement during postpartum haemorrhage: OBS2, a double-blind randomized controlled trial. Br J Anaesth. 2017;119:411-421 pubmed publisher
    Postpartum haemorrhage (PPH) can be exacerbated by haemostatic failure. We hypothesized that early fibrinogen replacement, guided by viscoelastometric testing, reduces blood product usage and bleed size.
  52. Letchworth P, Duffy S, Phillips D. Improving non-technical skills (teamwork) in post-partum haemorrhage: A grouped randomised trial. Eur J Obstet Gynecol Reprod Biol. 2017;217:154-160 pubmed publisher
    ..on teamwork and associated non-technical (NTS) and technical skills when teams manage post-partum haemorrhage (PPH) in the simulated environment...
  53. Gao S, Hu X. Nickel-catalyzed ring-opening of α-hydroxycyclobutenones with a remarkable ligand effect. Chem Commun (Camb). 2017;53:10540-10543 pubmed publisher
    ..A remarkable ligand effect was observed during transformations following the ring-opening. The employment of PPh3 leads to the formation of 2-furanones 2 through a migration of an alkoxyl group, and 2-furanones 3 were ..
  54. Huang T, Huang L, Jiang Y, Hu F, Sun Z, Pan G, et al. Direct self-focusing synthesis of monodisperse [Au8(PPh3)7]2+ nanoclusters. Dalton Trans. 2017;46:12239-12244 pubmed publisher
    ..In this study, we found that Au(PPh3)2Cl could be used as an effective precursor for the direct synthesis of atomically ..
  55. Bock A, Tucker N, Kelher M, Khan S, Gonzalez E, Wohlauer M, et al. α-Enolase Causes Proinflammatory Activation of Pulmonary Microvascular Endothelial Cells and Primes Neutrophils Through Plasmin Activation of Protease-Activated Receptor 2. Shock. 2015;44:137-42 pubmed publisher
    ..Enolase increases after injury and may activate pulmonary endothelial cells and prime PMNs through plasmin activity and PAR-2 activation. Such proinflammatory endothelial activation may predispose to PMN-mediated organ injury. ..
  56. Mishra K, Agrahari A, Tiwari V. One-pot synthesis of oxazolidine-2-thione and thiozolidine-2-thione from sugar azido-alcohols. Carbohydr Res. 2017;450:1-9 pubmed publisher
    ..thiozolidine-2-thiones has been accomplished from corresponding sugar azido alcohols utilizing Staudinger reaction (PPh3 and CS2) via isothiocynate route...
  57. Paludo G, Lorenzatto K, Bonatto D, Ferreira H. Systems biology approach reveals possible evolutionarily conserved moonlighting functions for enolase. Comput Biol Chem. 2015;58:1-8 pubmed publisher
    ..Overall, our results provided evidences of enolase multifunctionality and evolutionary conservation of enolase PPIs at all these levels. ..
  58. Erdem A, Sahin Y, Dogan N, Umudum Z, Bayar F, Bulut C, et al. Effects of sevoflurane and propofol on S100β and neuron-specific enolase protein levels during cardiopulmonary bypass. Niger J Clin Pract. 2016;19:278-83 pubmed publisher
    ..001 and 0.047, respectively). Our findings showed that both S100β and NSE levels similarly increased during CPB and immediately after CPB during sevoflurane and propofol based anesthesia. ..
  59. Fischer Fodor E, Vălean A, Virag P, Ilea P, Tatomir C, Imre Lucaci F, et al. Gallium phosphinoarylbisthiolato complexes counteract drug resistance of cancer cells. Metallomics. 2014;6:833-44 pubmed publisher
    ..of two recently synthesized gallium phosphinoarylbisthiolato complexes was studied, having the formula [X][Ga{PPh(2-SC6H4)2-κ(3)S,S',P}{PPh(2-SC6H4)2-κ(2)S,S'}] where [X] is either the NEt3H (1) or PPh4 (2) cation...
  60. Roy S, Pramanik S, Patra S, Adhikari B, Mondal A, Ganguly S, et al. Ambient-Stable Bis-Azoaromatic-Centered Diradical [(L•)M(L•)] Complexes of Rh(III): Synthesis, Structure, Redox, and Spin-Spin Interaction. Inorg Chem. 2017;56:12764-12774 pubmed publisher
    ..The less stable monoradical [RhIII(1•-)Cl2(PPh3)3] (3) has also been isolated as a minor product...
  61. Alvarez M, García M, Garcia Vivo D, Rueda M, Ruiz M, Toyos A, et al. Terminal vs. bridging coordination of CO and NO ligands after decarbonylation of [W2Cp2(μ-PR2)(CO)3(NO)] complexes (R = Ph, Cy). An experimental and computational study. Dalton Trans. 2017;46:10440-10451 pubmed publisher
    Compounds [M2Cp2(μ-PPh2)(CO)3(NO)] (M = Mo, W) were prepared by reacting the corresponding radicals [M2Cp2(μ-PPh2)(CO)4] with NO, and displayed a ..
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    Objective Postpartum hemorrhage (PPH) has a continuously rising incidence worldwide, suggesting suboptimal care. An important step in optimizing care is the translation of evidence-based guidelines into comprehensive hospital protocols...