ENL

Summary

Gene Symbol: ENL
Description: MLLT1, super elongation complex subunit
Alias: ENL, LTG19, YEATS1, protein ENL, CTC-503J8.6, ENL/MLL fusion, MLL/ENL fusion protein, MLLT1/MLL fusion, YEATS domain-containing protein 1, myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 1, myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1
Species: human
Products:     ENL

Top Publications

  1. Yokoyama A, Lin M, Naresh A, Kitabayashi I, Cleary M. A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription. Cancer Cell. 2010;17:198-212 pubmed publisher
    AF4 and ENL family proteins are frequently fused with MLL, and they comprise a higher order complex (designated AEP) containing the P-TEFb transcription elongation factor...
  2. He N, Chan C, Sobhian B, Chou S, Xue Y, Liu M, et al. Human Polymerase-Associated Factor complex (PAFc) connects the Super Elongation Complex (SEC) to RNA polymerase II on chromatin. Proc Natl Acad Sci U S A. 2011;108:E636-45 pubmed publisher
    ..The Super Elongation Complex (SEC), containing transcription elongation activators/coactivators P-TEFb, ELL2, AFF4/1, ENL, and AF9, is recruited by HIV-1 Tat and mixed lineage leukemia (MLL) proteins to activate the expression of HIV-1 ..
  3. Tkachuk D, Kohler S, Cleary M. Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias. Cell. 1992;71:691-700 pubmed
    ..11 transcript codes for a chimeric protein containing the AT hook motifs fused to a previously undescribed protein (ENL) from chromosome 19...
  4. He N, Liu M, Hsu J, Xue Y, Chou S, Burlingame A, et al. HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription. Mol Cell. 2010;38:428-38 pubmed publisher
    ..Using a sequential affinity-purification scheme, we have identified human transcription factors/coactivators AFF4, ENL, AF9, and elongation factor ELL2 as components of the Tat-P-TEFb complex...
  5. Sobhian B, Laguette N, Yatim A, Nakamura M, Levy Y, Kiernan R, et al. HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP. Mol Cell. 2010;38:439-51 pubmed publisher
    ..Tatcom1 consists of the core active P-TEFb, MLL-fusion partners involved in leukemia (AF9, AFF4, AFF1, ENL, and ELL), and PAF1 complex...
  6. Yamamoto K, Seto M, Komatsu H, Iida S, Akao Y, Kojima S, et al. Two distinct portions of LTG19/ENL at 19p13 are involved in t(11;19) leukemia. Oncogene. 1993;8:2617-25 pubmed
    ..basis for the heterogeneity, we isolated cDNA clones of a translocation-associated gene on chromosome 19, LTG19, as well as chimeric cDNAs from KOPN-1...
  7. Garcia Cuellar M, Zilles O, Schreiner S, Birke M, Winkler T, Slany R. The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3. Oncogene. 2001;20:411-9 pubmed
    ..This event truncates the proto-oncogene MLL and fuses the 5' end of MLL in frame with the ENL gene. ENL contributes a crucial protein-protein interaction domain to the resulting oncoprotein MLL-ENL...
  8. Zeisig D, Bittner C, Zeisig B, Garcia Cuellar M, Hess J, Slany R. The eleven-nineteen-leukemia protein ENL connects nuclear MLL fusion partners with chromatin. Oncogene. 2005;24:5525-32 pubmed
    ..In two-hybrid studies, ENL interacted with AF4 and AF5q31 as well as with a fragment of AF10...
  9. Rubnitz J, Morrissey J, Savage P, Cleary M. ENL, the gene fused with HRX in t(11;19) leukemias, encodes a nuclear protein with transcriptional activation potential in lymphoid and myeloid cells. Blood. 1994;84:1747-52 pubmed
    ..We have characterized the transcriptional transactivation properties of Enl, a protein that is fused to Hrx in t(11;19) leukemias...

More Information

Publications118 found, 100 shown here

  1. Rowe R, Lummertz da Rocha E, Sousa P, Missios P, Morse M, Marion W, et al. The developmental stage of the hematopoietic niche regulates lineage in MLL-rearranged leukemia. J Exp Med. 2019;216:527-538 pubmed publisher
    ..In MLL-ENL leukemia, the neonatal microenvironment potentiated B-lymphoid differentiation compared with the adult...
  2. Charytoniuk T, Iłowska N, Berk K, Drygalski K, Chabowski A, Konstantynowicz Nowicka K. The effect of enterolactone on sphingolipid pathway and hepatic insulin resistance development in HepG2 cells. Life Sci. 2019;217:1-7 pubmed publisher
    ..Therefore, the aim of this study was to ascertain whether enterolactone (ENL), a commonly known phytoestrogen, may affect sphingolipid metabolism and decrease hepatic insulin resistance ..
  3. Berk K, Drygalski K, Harasim Symbor E, Charytoniuk T, Iłowska N, Łukaszuk B, et al. The effect of enterolactone on liver lipid precursors of inflammation. Life Sci. 2019;221:341-347 pubmed publisher
    The aim of this study was to assess the effects of enterolactone (ENL) on lipid fractions fatty acids composition affecting hepatocyte inflammation development...
  4. Suryawati N, Saputra H. Erythema nodosum leprosum presenting as sweet's syndrome-like reaction in a borderline lepromatous leprosy patient. Int J Mycobacteriol. 2018;7:191-194 pubmed publisher
    Erythema nodosum leprosum (ENL) is characterized by tender erythematous nodules, accompanied by fever, malaise, arthralgia, and systemic complications...
  5. Park S, You E, Park C, Jang S, Cho Y, Yoon C, et al. The Incidence and Immunophenotypic and Genetic Features of JL1 Expressing Cells and the Therapeutic Potential of an Anti-JL1 Antibody in De Novo Pediatric Acute Leukemias. Ann Lab Med. 2019;39:358-366 pubmed publisher
    ..Future studies should examine the prognostic impact of JL1 expression in pediatric acute leukemias. ..
  6. Kamezaki K, Luchsinger L, Snoeck H. Differential requirement for wild-type Flt3 in leukemia initiation among mouse models of human leukemia. Exp Hematol. 2014;42:192-203.e1 pubmed publisher
    ..models established by retroviral transduction of leukemic fusion proteins, deletion of Flt3 strongly inhibits MLL-ENL and to lesser extent p210(BCR-ABL)-induced leukemogenesis, but has no effect in MLL-AF9 or AML1-ETO9a models...
  7. Jiang J, Gai Z, Wang Y, Fan K, Sun L, Wang H, et al. Comprehensive proteome analyses of lysine acetylation in tea leaves by sensing nitrogen nutrition. BMC Genomics. 2018;19:840 pubmed publisher
    ..and glycolysis were found to be acetylated, including LHCA1, LHCA3, LHCB6, psaE, psaD, psaN, GAPDH, PEPC, ENL and petC...
  8. Arora N, Manipadam M, Nair S. Frequency and distribution of lymphoma types in a tertiary care hospital in South India: analysis of 5115 cases using the World Health Organization 2008 classification and comparison with world literature. Leuk Lymphoma. 2013;54:1004-11 pubmed publisher
    ..Mixed cellularity (MC-CHL) (n = 488, 45%) was the major subtype of HL. Primary extranodal lymphoma (ENL) accounted for 32.8% (n = 1321) of all NHLs and most frequently involved the gastrointestinal tract...
  9. Li X, Li X, Jiang Y, Liu Z, Cui Y, Fung K, et al. Structure-guided development of YEATS domain inhibitors by targeting π-π-π stacking. Nat Chem Biol. 2018;14:1140-1149 pubmed publisher
    ..in the selective inhibitors preferentially binding to individual YEATS-containing proteins including AF9 and ENL with submicromolar affinities...
  10. Liu F, Gao L, Jing Y, Xu Y, Ding Y, Zhou M, et al. Detection and clinical significance of gene rearrangements in Chinese patients with adult acute lymphoblastic leukemia. Leuk Lymphoma. 2013;54:1521-6 pubmed publisher
    ..15% (90/256) for the 10 fusion genes. BCR-ABL1, FUS-ERG, MLL-AF4, ETV6-RUNX1, E2A-PBX1, dupMLL, MLL-AF10, MLL-ENL, SET-NUP214 and SIL-TAL1 were detected in 36 (14.06%), 14 (5.47%), 14 (5.47%), four (1.56%), four (1.56%), five (1...
  11. Bowers L, Lineberger C, Ford N, Rossi E, Punjala A, Camp K, et al. The flaxseed lignan secoisolariciresinol diglucoside decreases local inflammation, suppresses NFκB signaling, and inhibits mammary tumor growth. Breast Cancer Res Treat. 2019;173:545-557 pubmed publisher
    Exposure to the polyphenolic plant lignan secoisolariciresinol diglucoside (SDG) and its metabolite enterolactone (ENL) has been associated with reduced breast cancer progression, particularly for estrogen receptor alpha (ERα)-negative ..
  12. Almousa A, Meurens F, Krol E, Alcorn J. Linoorbitides and enterolactone mitigate inflammation-induced oxidative stress and loss of intestinal epithelial barrier integrity. Int Immunopharmacol. 2018;64:42-51 pubmed publisher
    ..This study investigated the ability of flax linoorbitides (LOBs) and enterolactone (ENL), to mitigate inflammation-induced loss of intestinal epithelial barrier integrity and oxidative stress in vitro...
  13. Schexnaydre E, Gerstmeier J, Garscha U, Jordan P, Werz O, Newcomer M. A 5‑lipoxygenase-specific sequence motif impedes enzyme activity and confers dependence on a partner protein. Biochim Biophys Acta Mol Cell Biol Lipids. 2019;1864:543-551 pubmed publisher
    ..A 5-LOX mutant in which KKK653-655 is replaced by ENL was transfected into HEK293 cells in the absence and presence of FLAP...
  14. Chowdhry S, Shukla A, D Souza P, Dhali T, Jaiswal P. Treatment of severe refractory erythema nodosum leprosum with tumor necrosis factor inhibitor Etanercept. Int J Mycobacteriol. 2016;5:223-5 pubmed publisher
    Erythema nodosum leprosum (ENL) is a common complication of lepromatous leprosy. Some patients unresponsive to conventional, first-line therapeutics develop recurrent, recalcitrant ENL...
  15. Dias A, Silva C, Santos J, Batista Silva L, Acosta C, Fontes A, et al. DNA Sensing via TLR-9 Constitutes a Major Innate Immunity Pathway Activated during Erythema Nodosum Leprosum. J Immunol. 2016;197:1905-13 pubmed publisher
    ..course of lepromatous leprosy may be interrupted by acute inflammatory episodes known as erythema nodosum leprosum (ENL)...
  16. van der Linden M, Seslija L, Schneider P, Driessen E, Castro P, Stumpel D, et al. Identification of genes transcriptionally responsive to the loss of MLL fusions in MLL-rearranged acute lymphoblastic leukemia. PLoS ONE. 2015;10:e0120326 pubmed publisher
    ..For this, we performed gene expression profiling after siRNA-mediated repression of MLL-AF4, MLL-ENL, and AF4-MLL in MLL-rearranged ALL cell line models...
  17. Suzuki K, Kimura T, Shinoda H, Bai G, Daniels M, Arai Y, et al. Five colour variants of bright luminescent protein for real-time multicolour bioimaging. Nat Commun. 2016;7:13718 pubmed publisher
    ..Here we report five new spectral variants of the bright luminescent protein, enhanced Nano-lantern (eNL), made by concatenation of the brightest luciferase, NanoLuc, with various colour hues of fluorescent proteins...
  18. Kumar P, Kumar H, Sundaresan L, Ghosh A, Kathirvel P, Thilak A, et al. Thalidomide remodels developing heart in chick embryo: discovery of a thalidomide mediated hematoma in heart muscle. Naunyn Schmiedebergs Arch Pharmacol. 2018;391:1093-1105 pubmed publisher
    ..caused by thalidomide in 1960s, the drug came to clinical use again for the treatment of erythema nodosum leprosum (ENL) and multiple myeloma...
  19. Yahalom J, Illidge T, Specht L, Hoppe R, Li Y, Tsang R, et al. Modern radiation therapy for extranodal lymphomas: field and dose guidelines from the International Lymphoma Radiation Oncology Group. Int J Radiat Oncol Biol Phys. 2015;92:11-31 pubmed publisher
    ..Radiation therapy (RT) is frequently used as either primary therapy (particularly for indolent ENL), consolidation after systemic therapy, salvage treatment, or palliation...
  20. Wai D, Szyszka T, Campbell A, Kwong C, Wilkinson White L, Silva A, et al. The BRD3 ET domain recognizes a short peptide motif through a mechanism that is conserved across chromatin remodelers and transcriptional regulators. J Biol Chem. 2018;293:7160-7175 pubmed publisher
    ..NMR-based structural analysis revealed that, surprisingly, this mode of interaction is shared by the AF9 and ENL transcriptional coregulators that contain an acetyl-lysine-binding YEATS domain and regulate transcriptional ..
  21. Hsu C, Zhao D, Shi J, Peng D, Guan H, Li Y, et al. Gas41 links histone acetylation to H2A.Z deposition and maintenance of embryonic stem cell identity. Cell Discov. 2018;4:28 pubmed publisher
    ..structure of the Gas41 YEATS domain in complex with the H3K27ac peptide revealed that, similar to the AF9 and ENL YEATS domains, Gas41 YEATS forms a serine-lined aromatic cage for acetyllysine recognition...
  22. Aoki Y, Watanabe T, Saito Y, Kuroki Y, Hijikata A, Takagi M, et al. Identification of CD34+ and CD34- leukemia-initiating cells in MLL-rearranged human acute lymphoblastic leukemia. Blood. 2015;125:967-80 pubmed publisher
    Translocation of the mixed-lineage leukemia (MLL) gene with AF4, AF9, or ENL results in acute leukemia with both lymphoid and myeloid involvement...
  23. Kumar N, Sharma U, Singh C, Singh B. Thalidomide: chemistry, therapeutic potential and oxidative stress induced teratogenicity. Curr Top Med Chem. 2012;12:1436-55 pubmed
    ..of a marketed drug came in 1998 when it received FDA approval for the treatment of erythema nodosum leprosum (ENL). Recently, the drug has got FDA approval for the treatment of multiple myeloma...
  24. Saini C, Tarique M, Ramesh V, Khanna N, Sharma A. γδ T cells are associated with inflammation and immunopathogenesis of leprosy reactions. Immunol Lett. 2018;200:55-65 pubmed publisher
    ..T cells were significantly increased in both Reversal reaction (RR) and Erythema nodosum leprosum (ENL) reaction patients. These cells produced significant amount of IL-17 and IFN-γ...
  25. Mahajan V, Abhinav C, Mehta K, Chauhan P. Erythema nodosum leprosum mimicking Sweet's syndrome: an uncommon presentation. Lepr Rev. 2014;85:322-7 pubmed
    Erythema nodosum leprosum (ENL) lesions may uncommonly develop ulceration, necrosis, pustulation or bullae...
  26. Zhou J, Ng Y, Chng W. ENL: structure, function, and roles in hematopoiesis and acute myeloid leukemia. Cell Mol Life Sci. 2018;75:3931-3941 pubmed publisher
    b>ENL/MLLT1 is a distinctive member of the KMT2 family based on its structural homology. ENL is a histone acetylation reader and a critical component of the super elongation complex...
  27. Lokken A, Achille N, Chang M, Lin J, Kuntimaddi A, Leach B, et al. Importance of a specific amino acid pairing for murine MLL leukemias driven by MLLT1/3 or AFF1/4. Leuk Res. 2014;38:1309-15 pubmed publisher
  28. Hullar M, Lancaster S, Li F, Tseng E, Beer K, Atkinson C, et al. Enterolignan-producing phenotypes are associated with increased gut microbial diversity and altered composition in premenopausal women in the United States. Cancer Epidemiol Biomarkers Prev. 2015;24:546-54 pubmed publisher
    Lignans in plant foods are metabolized by gut bacteria to the enterolignans, enterodiol (END) and enterolactone (ENL). Enterolignans have biologic activities important to the prevention of cancer and chronic diseases...
  29. Jaskulski S, Jung A, Rudolph A, Johnson T, Thöne K, Herpel E, et al. Genistein and enterolactone in relation to Ki-67 expression and HER2 status in postmenopausal breast cancer patients. Mol Nutr Food Res. 2017;61: pubmed publisher
    ..We examined associations between the major metabolites of lignans and isoflavones - enterolactone (ENL) and genistein (GEN) - respectively, and Ki-67 expression and HER2 in tumor tissue of breast cancer patients...
  30. Okuda H, Stanojevic B, Kanai A, Kawamura T, Takahashi S, Matsui H, et al. Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia. J Clin Invest. 2017;127:1918-1931 pubmed publisher
    The eleven-nineteen leukemia (ENL) protein family, composed of ENL and AF9, is a common component of 3 transcriptional modulators: AF4-ENL-P-TEFb complex (AEP), DOT1L-AF10-ENL complex (referred to as the DOT1L complex) and polycomb-..
  31. Katsura M, Nishina H, Shigemori Y, Nakanishi T. Extranodal lymphoma originating in the gluteal muscle with adjacent bone involvement and mimicking a soft tissue sarcoma. Int J Surg Case Rep. 2015;7C:161-4 pubmed publisher
    Extranodal lymphoma (ENL) in the muscles is a rare manifestation of non-Hodgkin lymphoma (NHL)...
  32. Magnani C, Mezzanotte C, Cappuzzello C, Bardini M, Tettamanti S, Fazio G, et al. Preclinical efficacy and safety of CD19CAR Cytokine-induced killer (CIK) cells transfected with Sleeping Beauty transposon for the treatment of acute lymphoblastic leukemia. Hum Gene Ther. 2018;: pubmed publisher
    ..CARCIK-CD19 remained fully functional both in vitro and in a established patient-derived xenograft (PDX) of MLL-ENL rearranged acute lymphoblastic leukemia (ALL)...
  33. de Macedo C, de Carvalho F, Amaral J, de Mendonça Ochs S, Assis E, Sarno E, et al. Leprosy and its reactional episodes: Serum levels and possible roles of omega-3 and omega-6-derived lipid mediators. Cytokine. 2018;112:87-94 pubmed publisher
    ..The most frequent M. leprae-specific hypersensitivity reactions are erythema nodosum leprosum (ENL) and type-1 (reversal) reaction (T1R)...
  34. Di Y, Ji S, Wolf P, Krol E, Alcorn J. Enterolactone glucuronide and ?-glucuronidase in antibody directed enzyme prodrug therapy for targeted prostate cancer cell treatment. AAPS PharmSciTech. 2017;18:2336-2345 pubmed publisher
    ..preclinical and animal studies demonstrated an anticancer effect of flaxseed lignans, particularly enterolactone (ENL), against prostate cancer...
  35. Shamseddine L, Majzoub Z. Relative Translucency of a Multilayered Ultratranslucent Zirconia Material. J Contemp Dent Pract. 2017;18:1099-1106 pubmed
    ..four layers [dentin layer (DEL), first transitional layer (FTL), second transitional layer (STL), and enamel layer (ENL)] and four different thicknesses (0.4, 0.6, 0.8, and 1 mm) were milled from blanks...
  36. Egnell M, Kesse Guyot E, Galan P, Touvier M, Rayner M, Jewell J, et al. Impact of Front-of-Pack Nutrition Labels on Portion Size Selection: An Experimental Study in a French Cohort. Nutrients. 2018;10: pubmed publisher
    ..governments (Nutri-Score and Multiple Traffic Lights (MTL)) and one designed by industry (Evolved Nutrition Label (ENL)) are currently being discussed...
  37. Zghal I, Zgolli H, Fekih O, Chebbi A, Bouguila H, Nacef L. [Macula analysis by spectral domain OCT in rhegmatogenous retinal detachment surgery]. J Fr Ophtalmol. 2015;38:181-92 pubmed publisher
    ..001), disruptions of the MLE and/or IS/OS junction (P<0.001), as well as cystic cavities in the ENL and/or INL (P=0.002)...
  38. Rêgo J, de Lima Santana N, Machado P, Ribeiro Alves M, de Toledo Pinto T, Castellucci L, et al. Whole blood profiling of leprosy type 1(reversal) reactions highlights prominence of innate immune response genes. BMC Infect Dis. 2018;18:422 pubmed publisher
    ..permanent disabilities in leprosy are type 1 or reversal reactions (RR) and type 2 or erythema nodosum leprosum (ENL)...
  39. Burmeister T, Meyer C, Gröger D, Hofmann J, Marschalek R. Evidence-based RT-PCR methods for the detection of the 8 most common MLL aberrations in acute leukemias. Leuk Res. 2015;39:242-7 pubmed publisher
    ..methods for the reliable detection of the 8 most common MLL aberrations (MLL-AF4, MLL-AF6, MLL-AF9, MLL-AF10, MLL-ENL, MLL-ELL, MLL-EPS15, MLL PTD), together accounting for around 90% of MLL-r cases...
  40. Giridhar P, Mallick S, Bhasker S, Pathy S, Mohanti B, Biswas A, et al. Head and neck extra nodal NHL (HNENL)--Treatment Outcome and Pattern of failure--A Single Institution Experience. Asian Pac J Cancer Prev. 2015;16:6267-72 pubmed
    Extra nodal lymphoma (ENL) constitutes about 33 % of all non-Hodgkin's lymphoma. 18-28% develops in the head and neck region. A multimodality treatment with multi-agent chemotherapy (CT) and radiotherapy (RT) is considered optimum...
  41. Oliveira J, Rêgo J, de Lima Santana N, Braz M, Jamieson S, Vieira T, et al. The -308 bp TNF gene polymorphism influences tumor necrosis factor expression in leprosy patients in Bahia State, Brazil. Infect Genet Evol. 2016;39:147-154 pubmed publisher
    ..PB) and 47 multibacillary (MB) without reactions, and 69 reversal reaction (RR) and 78 erythema nodosum leprosum (ENL) with reactions. Logistic regression was used to compare patient groups with 331 healthy controls...
  42. van Duursen M, Nijmeijer S, Ruchirawat S, van den Berg M. Chemopreventive actions by enterolactone and 13 VIOXX-related lactone derivatives in H295R human adrenocortical carcinoma cells. Toxicol Lett. 2010;192:271-7 pubmed publisher
    ..We studied the naturally occurring phytochemical enterolactone (ENL) and 13 VIOXX-related lactone derivatives (CRI-1 to CRI-13) for their effects on CYP17 activity and expression and ..
  43. Shivappa N, Wirth M, Murphy E, Hurley T, Hebert J. Association between the Dietary Inflammatory Index (DII) and urinary enterolignans and C-reactive protein from the National Health and Nutrition Examination Survey-2003-2008. Eur J Nutr. 2019;58:797-805 pubmed publisher
    ..Data came from NHANES 2003-2008. Enterolignans [enterodiol (END) and enterolactone (ENL)] and CRP were assayed from urine and serum specimens, respectively...
  44. Kobayashi S, Obata M, Hagihara M, Motohashi K, Ito S, Ohshima R, et al. The presence of mature granulocytes/monocytes derived from leukemic cells in MLL-associated leukemia. Int J Hematol. 2009;90:591-596 pubmed publisher
    ..MLL partner genes were AF6, AF9, ELL, and ENL, respectively...
  45. Ren G, Chen C, Chen W, Huang Y, Qin L, Chen L. The treatment effects of flaxseed-derived secoisolariciresinol diglycoside and its metabolite enterolactone on benign prostatic hyperplasia involve the G protein-coupled estrogen receptor 1. Appl Physiol Nutr Metab. 2016;41:1303-1310 pubmed
    ..The present study showed that enterolactone (ENL), the mammalian metabolite of SDG, shared the similar binding site of G1 on a new type of membranous estrogen ..
  46. Tang R, Chen M, Zhou K, Chen D, Yu J, Hu W, et al. Prenatal lignan exposures, pregnancy urine estrogen profiles and birth outcomes. Environ Pollut. 2015;205:261-8 pubmed publisher
    ..positive associations between gestational age and urinary matairesinol (MAT), enterodiol (END) and enterolactone (ENL), as well as 16-hydroxylation pathway EMs...
  47. Yang N, Huh J, Chung W, Cho M, Ryu K, Chung H. KMT2A (MLL)-MLLT1 rearrangement in blastic plasmacytoid dendritic cell neoplasm. Cancer Genet. 2015;208:464-7 pubmed publisher
    ..We suggest that the pathogenesis of BPDCN could be associated with KMT2A (MLL) rearrangement (especially with KMT2A (MLL)-MLLT1) and further study on a larger number of cases is needed. ..
  48. Hungria E, Oliveira R, Penna G, Aderaldo L, Pontes M, Cruz R, et al. Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil. Infect Dis Poverty. 2016;5:110 pubmed
    ..and according to the development of leprosy reactions (reversal reaction/RR and erythema nodosum leprosum/ENL), and whether they had a positive or negative bacillary index/BI. More than half of the patients (55...
  49. Bergmann A, Castellano G, Alten J, Ammerpohl O, Kolarova J, Nordlund J, et al. DNA methylation profiling of pediatric B-cell lymphoblastic leukemia with KMT2A rearrangement identifies hypomethylation at enhancer sites. Pediatr Blood Cancer. 2017;64: pubmed publisher
    ..In summary, DNA methylation changes in KMT2Ar ALL target enhancers, genes involved in leukemogenesis and normal hematopoiesis, as well as transcription factor networks. ..
  50. Garcia Cuellar M, Büttner C, Bartenhagen C, Dugas M, Slany R. Leukemogenic MLL-ENL Fusions Induce Alternative Chromatin States to Drive a Functionally Dichotomous Group of Target Genes. Cell Rep. 2016;15:310-22 pubmed publisher
    ..Global transcription rates and chromatin changes accompanying the transformation process induced by MLL-ENL were monitored by nascent RNA-seq and ChIP-seq, revealing 165 direct target genes separated into two distinct ..
  51. Ney Garcia D, de Souza M, de Figueiredo A, Othman M, Rittscher K, Abdelhay E, et al. Molecular characterization of KMT2A fusion partner genes in 13 cases of pediatric leukemia with complex or cryptic karyotypes. Hematol Oncol. 2016;: pubmed publisher
    ..We conclude that the combination of molecular techniques used in this study can efficiently identify KMT2A fusion partners in complex pediatric acute leukemia karyotypes. Copyright © 2016 John Wiley & Sons, Ltd. ..
  52. Dubey A, Biswas S, Sinha E, Chakma J, Kamal R, Arora M, et al. Association of Nitric Oxide Synthase2 gene polymorphisms with leprosy reactions in northern Indian population. Infect Genet Evol. 2017;51:67-73 pubmed publisher
    ..frequency with leprosy cases (BL and LL) who were not suffering from any reactional episodes compared to cases with ENL reaction {OR=0.30, 95% CI (0.10-0.86), p=0.024}...
  53. Germano G, Morello G, Aveic S, Pinazza M, Minuzzo S, Frasson C, et al. ZNF521 sustains the differentiation block in MLL-rearranged acute myeloid leukemia. Oncotarget. 2017;8:26129-26141 pubmed publisher
    ..Finally, we determined that both MLL-AF9 and MLL-ENL fusion proteins directly interacted with ZNF521 promoter activating its transcription...
  54. Costa P, Fraga L, Kowalski T, Daxbacher E, Schuler Faccini L, Vianna F. Erythema Nodosum Leprosum: Update and challenges on the treatment of a neglected condition. Acta Trop. 2018;183:134-141 pubmed publisher
    Erythema Nodosum Leprosum (ENL) occurs due to the immunological complication of multibacillary leprosy and is characterized by painful nodules and systemic compromising...
  55. Doescher M, Lee C, Saelens B, Lee C, Berke E, Adachi Mejia A, et al. Utilitarian and Recreational Walking Among Spanish- and English-Speaking Latino Adults in Micropolitan US Towns. J Immigr Minor Health. 2017;19:237-245 pubmed publisher
    ..SSLs reported lower amounts of recreational walking than ENLs (p = 0.004). ESL-ENL differences were not significant...
  56. Bilardi R, Anstee N, Glaser S, Robati M, Vandenberg C, Cory S. Impact of loss of BH3-only proteins on the development and treatment of MLL-fusion gene-driven AML in mice. Cell Death Dis. 2016;7:e2351 pubmed publisher
    ..3 (BH3)-only proteins impact on acute myeloid leukemia (AML), we generated mixed lineage leukemia (MLL)-AF9 and MLL-ENL AMLs from BH3-only gene knockout mice...
  57. Yokogawa T, Sasaki Y, Ando H, Yamamoto K, Mikage M. Pharmacological evaluation for improvement of Kanazawa Sutra, medicinal thread for anal fistula. J Nat Med. 2017;71:339-348 pubmed publisher
    ..We found that MJB extracts showed similar biological activity to Euphorbia neriifolia latex (ENL), an ingredient of KS...
  58. Reimer J, Knöß S, Labuhn M, Charpentier E, Göhring G, Schlegelberger B, et al. CRISPR-Cas9-induced t(11;19)/MLL-ENL translocations initiate leukemia in human hematopoietic progenitor cells in vivo. Haematologica. 2017;102:1558-1566 pubmed publisher
    ..efficiently transduced human CD34+ hematopoietic stem and progenitor cells and induced the t(11;19)/MLL-ENL translocation...
  59. Shields B, Jackson J, Metcalf D, Shi W, Huang Q, Garnham A, et al. Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2a. Genes Dev. 2016;30:78-91 pubmed publisher
    ..Hhex is overexpressed in acute myeloid leukemia (AML) and is essential for the initiation and propagation of MLL-ENL-induced AML but dispensable for normal myelopoiesis, indicating a specific requirement for Hhex for leukemic growth...
  60. Yokoyama A. Transcriptional activation by MLL fusion proteins in leukemogenesis. Exp Hematol. 2017;46:21-30 pubmed publisher
    ..Fusion proteins of MLL and a component of the AF4 family/ENL family/P-TEFb complex (AEP) are responsible for two-thirds of MLL-associated leukemia cases...
  61. Biagi L, Ramkissoon C, Facchinetti A, Leal Y, Vehí J. Modeling the Error of the Medtronic Paradigm Veo Enlite Glucose Sensor. Sensors (Basel). 2017;17: pubmed publisher
    ..The aim of this study is to derive the model of the error of the second generation Medtronic Paradigm Veo Enlite (ENL) sensor and compare it with the Dexcom SEVEN PLUS (7P), G4 PLATINUM (G4P), and advanced G4 for Artificial Pancreas ..
  62. Watson A, Riffelmacher T, Stranks A, Williams O, de Boer J, Cain K, et al. Autophagy limits proliferation and glycolytic metabolism in acute myeloid leukemia. Cell Death Discov. 2015;1: pubmed
    ..Crucially, heterozygous loss of autophagy in an MLL-ENL model of AML led to increased proliferation in vitro, a glycolytic shift, and more aggressive leukemias in vivo...
  63. Okuda H, Kanai A, Ito S, Matsui H, Yokoyama A. AF4 uses the SL1 components of RNAP1 machinery to initiate MLL fusion- and AEP-dependent transcription. Nat Commun. 2015;6:8869 pubmed publisher
    ..In most cases, MLL fuses with a gene encoding a component of the AEP (AF4 family/ENL family/P-TEFb) coactivator complex...
  64. Charng W, Karaca E, Coban Akdemir Z, Gambin T, Atik M, Gu S, et al. Exome sequencing in mostly consanguineous Arab families with neurologic disease provides a high potential molecular diagnosis rate. BMC Med Genomics. 2016;9:42 pubmed publisher
    ..Novel candidate disease gene discovery is facilitated by paralog studies and through the use of informatics tools and available databases to identify additional evidence for pathogenicity. Not applicable. ..
  65. Schmitz V, Prata R, Barbosa M, Mendes M, Brandão S, Amadeu T, et al. Expression of CD64 on Circulating Neutrophils Favoring Systemic Inflammatory Status in Erythema Nodosum Leprosum. PLoS Negl Trop Dis. 2016;10:e0004955 pubmed publisher
    Erythema Nodosum Leprosum (ENL) is an immune reaction in leprosy that aggravates the patient´s clinical condition...
  66. Di Cio S, Bøggild T, Connelly J, Sutherland D, Gautrot J. Differential integrin expression regulates cell sensing of the matrix nanoscale geometry. Acta Biomater. 2017;50:280-292 pubmed publisher
    ..Here we develop a new nanopatterning technique, electrospun nanofiber lithography (ENL), which allows the production of a quasi-2D fibrous nanopattern with controlled dimensions (250-1000nm) and ..
  67. Zhao D, Li Y, Xiong X, Chen Z, Li H. YEATS Domain-A Histone Acylation Reader in Health and Disease. J Mol Biol. 2017;429:1994-2002 pubmed publisher
    ..The Yaf9, ENL, AF9, Taf14, Sas5 (YEATS) domain is an emerging reader module that selectively recognizes histone lysine acylation ..
  68. Zhou F, Furuhashi K, Son M, Toyozaki M, Yoshizawa F, Miura Y, et al. Antidiabetic effect of enterolactone in cultured muscle cells and in type 2 diabetic model db/db mice. Cytotechnology. 2017;69:493-502 pubmed publisher
    Enterolactone (ENL) is formed by the conversion of dietary precursors like strawberry lignans via the gut microbiota...
  69. Monroe S, Jo S, Sanders D, Basrur V, Elenitoba Johnson K, Slany R, et al. MLL-AF9 and MLL-ENL alter the dynamic association of transcriptional regulators with genes critical for leukemia. Exp Hematol. 2011;39:77-86.e1-5 pubmed publisher
    ..Consistent with earlier purifications of ENL and AF4 from 293 cells, the 90 amino acid C-terminal domain of AF9 associates with many other MLL translocation ..
  70. Liu H, Liu J, Wang S, Zeng Z, Li T, Liu Y, et al. Enterolactone has stronger effects than enterodiol on ovarian cancer. J Ovarian Res. 2017;10:49 pubmed publisher
    ..Enterodiol (END) and enterolactone (ENL) are mammalian lignans, which can reduce the risk of various cancers...
  71. Drygalski K, Berk K, Charytoniuk T, Iłowska N, Łukaszuk B, Chabowski A, et al. Does the enterolactone (ENL) affect fatty acid transporters and lipid metabolism in liver?. Nutr Metab (Lond). 2017;14:69 pubmed publisher
    ..Hence, the aim of the present study was to evaluate the effect(s) of enterolactone (ENL), a metabolite of secoisolariciresinol (SECO), on lipid metabolism together with changes in the expression of fatty ..
  72. Thirman M, Levitan D, Kobayashi H, Simon M, Rowley J. Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia. Proc Natl Acad Sci U S A. 1994;91:12110-4 pubmed
    ..3 breakpoint that results in the fusion of MLL to the ENL gene...
  73. Elia L, Grammatico S, Paoloni F, Vignetti M, Rago A, Cenfra N, et al. Clinical outcome and monitoring of minimal residual disease in patients with acute lymphoblastic leukemia expressing the MLL/ENL fusion gene. Am J Hematol. 2011;86:993-7 pubmed publisher
    We analyzed 12 MLL/ENL positive ALL patients consecutively diagnosed between 1999 and 2009. The MLL/ENL fusion was identified in 4/150 (2.6%), 8/993 (0.8%), and 0/70 of pediatric, adult, and elderly patients, respectively...
  74. Lu H, Li Z, Xue Y, Schulze Gahmen U, Johnson J, Krogan N, et al. AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation. Proc Natl Acad Sci U S A. 2014;111:E15-24 pubmed publisher
    ..Our data identify AFF1 as a ubiquitous P-TEFb partner and demonstrate that full Tat transactivation requires the complete SEC. ..
  75. Morgado Palacin I, Day A, Murga M, Lafarga V, Anton M, Tubbs A, et al. Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML. Sci Signal. 2016;9:ra91 pubmed publisher
    ..sensor of DNA replication stress, induced chromosomal breakage and death of mouse AML(MLL) cells (with an MLL-ENL fusion and a constitutively active N-RAS independently of p53...
  76. Patel A, Vought V, Dharmarajan V, Cosgrove M. A conserved arginine-containing motif crucial for the assembly and enzymatic activity of the mixed lineage leukemia protein-1 core complex. J Biol Chem. 2008;283:32162-75 pubmed publisher
    ..We demonstrate that WDR5's recognition of arginine 3765 of MLL1 is essential for the assembly and enzymatic activity of the MLL1 core complex in vitro. ..
  77. Karn J, Stoltzfus C. Transcriptional and posttranscriptional regulation of HIV-1 gene expression. Cold Spring Harb Perspect Med. 2012;2:a006916 pubmed publisher
    ..In cells that are not fully activated, limiting levels of Tat and Rev act as potent blocks to premature virus production. ..
  78. Liu M, Hsu J, Chan C, Li Z, Zhou Q. The ubiquitin ligase Siah1 controls ELL2 stability and formation of super elongation complexes to modulate gene transcription. Mol Cell. 2012;46:325-34 pubmed publisher
    ..Given its importance in formation of SECs, the Siah1 ubiquitination pathway provides a fresh avenue for developing strategies to control disease-related transcription. ..
  79. Barretto N, Karahalios D, You D, Hemenway C. An AF9/ENL-targted peptide with therapeutic potential in mixed lineage leukemias. J Exp Ther Oncol. 2014;10:293-300 pubmed
    Misregulation of transcription elongation is proposed to underlie the pathobiology of MLL leukemia. AF4, AF9, and ENL, common MLL fusion partners, are found in complex with positive transcription elongation factor b (P-TEFb)...
  80. Negera E, Walker S, Girma S, Doni S, Tsegaye D, Lambert S, et al. Clinico-pathological features of erythema nodosum leprosum: A case-control study at ALERT hospital, Ethiopia. PLoS Negl Trop Dis. 2017;11:e0006011 pubmed publisher
    Leprosy reactions are a significant cause of morbidity in leprosy population. Erythema nodosum leprosum (ENL) is an immunological complication affecting approximately 50% of patients with lepromatous leprosy (LL) and 10% of borderline ..
  81. Hetzner K, Garcia Cuellar M, Büttner C, Slany R. The interaction of ENL with PAF1 mitigates polycomb silencing and facilitates murine leukemogenesis. Blood. 2017;: pubmed publisher
    b>ENL is a chromatin reader present in complexes stimulating transcriptional elongation. It is fused to MLL in leukemia and missense mutations have been identified in Wilms' tumor and AML...
  82. Wallström P, Drake I, Sonestedt E, Gullberg B, Bjartell A, Olsson H, et al. Plasma enterolactone and risk of prostate cancer in middle-aged Swedish men. Eur J Nutr. 2018;57:2595-2606 pubmed publisher
    Enterolactone (ENL) is formed in the human gut after consumption of lignans, has estrogenic properties, and has been associated with risk of prostate cancer...
  83. Gué M, Sun J, Boudier T. Simultaneous localization of MLL, AF4 and ENL genes in interphase nuclei by 3D-FISH: MLL translocation revisited. BMC Cancer. 2006;6:20 pubmed
    ..relative positions of the MLL gene with both the most frequent partner gene (AF4) and a less frequent partner gene (ENL), should elucidate the MLL translocation mechanism...
  84. Maethner E, Garcia Cuellar M, Breitinger C, Takacova S, Divoky V, Hess J, et al. MLL-ENL inhibits polycomb repressive complex 1 to achieve efficient transformation of hematopoietic cells. Cell Rep. 2013;3:1553-66 pubmed publisher
    ..Here, we provide evidence that MLL-ENL also inhibits Polycomb-mediated silencing as a prerequisite for efficient transformation...
  85. Miles F, Navarro S, Schwarz Y, Gu H, Djukovic D, Randolph T, et al. Plasma metabolite abundances are associated with urinary enterolactone excretion in healthy participants on controlled diets. Food Funct. 2017;8:3209-3218 pubmed publisher
    ..Enterolactone (ENL) and enterodiol, were measured in 24 h urine samples collected on the penultimate day of each study period using GC-..
  86. Mohan M, Herz H, Takahashi Y, Lin C, Lai K, Zhang Y, et al. Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom). Genes Dev. 2010;24:574-89 pubmed publisher
    ..Dot1 complex (DotCom), which includes several of the mixed lineage leukemia (MLL) partners in leukemia such as ENL, AF9/MLLT3, AF17/MLLT6, and AF10/MLLT10, as well as the known Wnt pathway modifiers TRRAP, Skp1, and beta-catenin...
  87. Mueller D, Garcia Cuellar M, Bach C, Buhl S, Maethner E, Slany R. Misguided transcriptional elongation causes mixed lineage leukemia. PLoS Biol. 2009;7:e1000249 pubmed publisher
    ..elongation complex that has been previously found associated with the eleven-nineteen leukemia protein (ENL). We show that this complex consists of a tight core stabilized by recursive protein-protein interactions...
  88. Nilson K, Price D. The Role of RNA Polymerase II Elongation Control in HIV-1 Gene Expression, Replication, and Latency. Genet Res Int. 2011;2011:726901 pubmed publisher
    ..HIV, the causative agent of AIDS, is a worldwide health concern. It is hoped that knowledge of the mechanisms regulating the expression of the HIV genome will lead to treatments and ultimately a cure. ..
  89. Taube R, Peterlin M. Lost in transcription: molecular mechanisms that control HIV latency. Viruses. 2013;5:902-27 pubmed publisher
  90. Lee S, Park T, Won S, Song J, Lee K, Choi J, et al. Three-way translocation involving MLL, MLLT1, and a novel third partner, NRXN1, in a patient with acute lymphoblastic leukemia and t(2;19;11) (p12;p13.3;q23). Cancer Genet Cytogenet. 2010;197:32-8 pubmed publisher
    ..The apparent three-way translocation thus identified is noteworthy because few studies have reported complex rearrangements involving 11q23 and 19p13.3 in acute leukemias. ..
  91. Afrin S, Zhang C, Meyer C, Stinson C, Pham T, Bruxner T, et al. Targeted Next-Generation Sequencing for Detecting MLL Gene Fusions in Leukemia. Mol Cancer Res. 2018;16:279-285 pubmed publisher
    ..Furthermore, this assay rapidly and reliably identifies MLL partner genes and patient-specific fusion sequences that could be used for monitoring minimal residual disease. Mol Cancer Res; 16(2); 279-85. ©2017 AACR. ..
  92. Wan L, Wen H, Li Y, Lyu J, Xi Y, Hoshii T, et al. ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia. Nature. 2017;543:265-269 pubmed publisher
    ..Here we show that the YEATS domain-containing protein ENL, but not its paralogue AF9, is required for disease maintenance in acute myeloid leukaemia...