emerin

Summary

Gene Symbol: emerin
Description: emerin
Alias: EDMD, LEMD5, STA, emerin, LEM domain containing 5
Species: human
Products:     emerin

Top Publications

  1. Nagano A, Koga R, Ogawa M, Kurano Y, Kawada J, Okada R, et al. Emerin deficiency at the nuclear membrane in patients with Emery-Dreifuss muscular dystrophy. Nat Genet. 1996;12:254-9 pubmed
    ..This gene encodes a hitherto unknown protein named 'emerin'...
  2. Holt I, Ostlund C, Stewart C, Man N, Worman H, Morris G. Effect of pathogenic mis-sense mutations in lamin A on its interaction with emerin in vivo. J Cell Sci. 2003;116:3027-35 pubmed
    ..studied the effects of nine pathogenic mutations on the ability of lamin A to assemble normally and to localize emerin normally at the nuclear rim...
  3. Holaska J, Wilson K. Multiple roles for emerin: implications for Emery-Dreifuss muscular dystrophy. Anat Rec A Discov Mol Cell Evol Biol. 2006;288:676-80 pubmed
    ..muscular dystrophy (X-EDMD) is inherited through mutations in EMD, which encodes a nuclear membrane protein named emerin. Emerin is expressed in most cells, but EDMD strikes specific tissues...
  4. Brachner A, Braun J, Ghodgaonkar M, Castor D, Zlopasa L, Ehrlich V, et al. The endonuclease Ankle1 requires its LEM and GIY-YIG motifs for DNA cleavage in vivo. J Cell Sci. 2012;125:1048-57 pubmed publisher
    The LEM domain (for lamina-associated polypeptide, emerin, MAN1 domain) defines a group of nuclear proteins that bind chromatin through interaction of the LEM motif with the conserved DNA crosslinking protein, barrier-to-autointegration ..
  5. Leach N, Bjerke S, Christensen D, Bouchard J, Mou F, Park R, et al. Emerin is hyperphosphorylated and redistributed in herpes simplex virus type 1-infected cells in a manner dependent on both UL34 and US3. J Virol. 2007;81:10792-803 pubmed publisher
    ..Here, we show that HSV-1 infection causes relocalization of the LEM domain protein emerin. In cells infected with wild-type virus, emerin becomes more mobile in the nuclear membrane, and in cells infected ..
  6. Ura S, Hayashi Y, Goto K, Astejada M, Murakami T, Nagato M, et al. Limb-girdle muscular dystrophy due to emerin gene mutations. Arch Neurol. 2007;64:1038-41 pubmed
    ..Muscle biopsy and mutation analysis results. Immunohistochemistry revealed an absence of emerin staining in muscle biopsy specimens. Mutation analysis identified nonsense mutations in EMD...
  7. Amanchy R, Kalume D, Iwahori A, Zhong J, Pandey A. Phosphoproteome analysis of HeLa cells using stable isotope labeling with amino acids in cell culture (SILAC). J Proteome Res. 2005;4:1661-71 pubmed
    ..Because of its sensitivity and general applicability, our approach will be useful for investigating signaling pathways in a global fashion and for using phosphoproteomics for functional annotation of genomes. ..
  8. Holaska J, Kowalski A, Wilson K. Emerin caps the pointed end of actin filaments: evidence for an actin cortical network at the nuclear inner membrane. PLoS Biol. 2004;2:E231 pubmed publisher
    X-linked Emery-Dreifuss muscular dystrophy is caused by loss of emerin, a LEM-domain protein of the nuclear inner membrane...
  9. Markiewicz E, Tilgner K, Barker N, van de Wetering M, Clevers H, Dorobek M, et al. The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleus. EMBO J. 2006;25:3275-85 pubmed
    b>Emerin is a type II inner nuclear membrane (INM) protein of unknown function. Emerin function is likely to be important because, when it is mutated, emerin promotes both skeletal muscle and heart defects...

More Information

Publications85

  1. Berk J, Tifft K, Wilson K. The nuclear envelope LEM-domain protein emerin. Nucleus. 2013;4:298-314 pubmed publisher
    b>Emerin, a conserved LEM-domain protein, is among the few nuclear membrane proteins for which extensive basic knowledge--biochemistry, partners, functions, localizations, posttranslational regulation, roles in development and links to ..
  2. Mislow J, Holaska J, Kim M, Lee K, Segura Totten M, Wilson K, et al. Nesprin-1alpha self-associates and binds directly to emerin and lamin A in vitro. FEBS Lett. 2002;525:135-40 pubmed
    ..Biochemical analysis demonstrated that nesprin-1alpha dimers bind directly to the nucleoplasmic domain of emerin, an inner nuclear membrane protein, with an affinity of 4 nM...
  3. Wheeler M, Davies J, Zhang Q, Emerson L, Hunt J, Shanahan C, et al. Distinct functional domains in nesprin-1alpha and nesprin-2beta bind directly to emerin and both interactions are disrupted in X-linked Emery-Dreifuss muscular dystrophy. Exp Cell Res. 2007;313:2845-57 pubmed
    b>Emerin and specific isoforms of nesprin-1 and -2 are nuclear membrane proteins which are binding partners in multi-protein complexes spanning the nuclear envelope...
  4. Lee K, Haraguchi T, Lee R, Koujin T, Hiraoka Y, Wilson K. Distinct functional domains in emerin bind lamin A and DNA-bridging protein BAF. J Cell Sci. 2001;114:4567-73 pubmed
    Loss of emerin, a lamin-binding nuclear membrane protein, causes Emery-Dreifuss muscular dystrophy. We analyzed 13 site-directed mutations, and four disease-causing mutations that do not disrupt emerin stability or localization...
  5. Haque F, Mazzeo D, Patel J, Smallwood D, Ellis J, Shanahan C, et al. Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes. J Biol Chem. 2010;285:3487-98 pubmed publisher
    ..Here, we identify emerin and short nesprin-2 isoforms as novel nucleoplasmic binding partners of SUN1/2...
  6. Cartegni L, Di Barletta M, Barresi R, Squarzoni S, Sabatelli P, Maraldi N, et al. Heart-specific localization of emerin: new insights into Emery-Dreifuss muscular dystrophy. Hum Mol Genet. 1997;6:2257-64 pubmed
    ..The EDMD geneencodes a novel ubiquitous protein, emerin, which decorates the nuclear rim of many cell types...
  7. Bione S, Maestrini E, Rivella S, Mancini M, Regis S, Romeo G, et al. Identification of a novel X-linked gene responsible for Emery-Dreifuss muscular dystrophy. Nat Genet. 1994;8:323-7 pubmed
    ..The EDMD gene encodes a novel serine-rich protein termed emerin, which contains a 20 amino acid hydrophobic domain at the C terminus, similar to that described for many membrane ..
  8. Bione S, Small K, Aksmanovic V, D Urso M, Ciccodicola A, Merlini L, et al. Identification of new mutations in the Emery-Dreifuss muscular dystrophy gene and evidence for genetic heterogeneity of the disease. Hum Mol Genet. 1995;4:1859-63 pubmed
    ..unrelated X-linked familial cases were studied and they all carried different mutations, showing that lack of emerin in cardiac and skeletal muscle is the cause of the X-linked disease...
  9. Salpingidou G, Smertenko A, Hausmanowa Petrucewicz I, Hussey P, Hutchison C. A novel role for the nuclear membrane protein emerin in association of the centrosome to the outer nuclear membrane. J Cell Biol. 2007;178:897-904 pubmed
    The type II inner nuclear membrane protein emerin is a component of the LINC complex that connects the nuclear lamina to the actin cytoskeleton...
  10. Karst M, Herron K, Olson T. X-linked nonsyndromic sinus node dysfunction and atrial fibrillation caused by emerin mutation. J Cardiovasc Electrophysiol. 2008;19:510-5 pubmed publisher
    ..Loss-of-function truncation mutations in EMD, encoding the nuclear membrane protein emerin, cause X-linked Emery-Dreifuss muscular dystrophy (EDMD) characterized by localized contractures and skeletal ..
  11. Tunnah D, Sewry C, Vaux D, Schirmer E, Morris G. The apparent absence of lamin B1 and emerin in many tissue nuclei is due to epitope masking. J Mol Histol. 2005;36:337-44 pubmed
    Immunolocalization studies have concluded that the nuclear membrane protein, emerin, is absent from many cell types and that lamin B1 is absent from adult heart and skeletal muscle...
  12. Brown C, Scharner J, Felice K, Meriggioli M, Tarnopolsky M, Bower M, et al. Novel and recurrent EMD mutations in patients with Emery-Dreifuss muscular dystrophy, identify exon 2 as a mutation hot spot. J Hum Genet. 2011;56:589-94 pubmed publisher
    ..X-linked EDMD arises from mutations in the EMD gene, which encodes for a nuclear membrane protein termed emerin. In this study, we describe novel and recurrent EMD mutations identified in 18 probands and three carriers from a ..
  13. Zhang Q, Ragnauth C, Skepper J, Worth N, Warren D, Roberts R, et al. Nesprin-2 is a multi-isomeric protein that binds lamin and emerin at the nuclear envelope and forms a subcellular network in skeletal muscle. J Cell Sci. 2005;118:673-87 pubmed
    ..The smaller isoforms of nesprin-2 co-localize with and bind lamin A and emerin at the inner nuclear envelope (NE)...
  14. Wolff N, Gilquin B, Courchay K, Callebaut I, Worman H, Zinn Justin S. Structural analysis of emerin, an inner nuclear membrane protein mutated in X-linked Emery-Dreifuss muscular dystrophy. FEBS Lett. 2001;501:171-6 pubmed
    ..The X-linked form of EDMD is caused by mutations in the emerin gene, whereas autosomal dominant EDMD is caused by mutations in the lamin A/C gene...
  15. Haraguchi T, Koujin T, Segura Totten M, Lee K, Matsuoka Y, Yoneda Y, et al. BAF is required for emerin assembly into the reforming nuclear envelope. J Cell Sci. 2001;114:4575-85 pubmed
    Mutations in emerin cause the X-linked recessive form of Emery-Dreifuss muscular dystrophy (EDMD)...
  16. Lattanzi G, Cenni V, Marmiroli S, Capanni C, Mattioli E, Merlini L, et al. Association of emerin with nuclear and cytoplasmic actin is regulated in differentiating myoblasts. Biochem Biophys Res Commun. 2003;303:764-70 pubmed
    b>Emerin is a nuclear envelope protein whose biological function remains to be elucidated. Mutations of emerin gene cause the Emery-Dreifuss muscular dystrophy, a neuromuscular disorder also linked to mutations of lamin A/C...
  17. Holaska J, Rais Bahrami S, Wilson K. Lmo7 is an emerin-binding protein that regulates the transcription of emerin and many other muscle-relevant genes. Hum Mol Genet. 2006;15:3459-72 pubmed
    X-linked Emery-Dreifuss muscular dystrophy (X-EDMD) is inherited through mutations in emerin, a nuclear membrane protein...
  18. Tifft K, Bradbury K, Wilson K. Tyrosine phosphorylation of nuclear-membrane protein emerin by Src, Abl and other kinases. J Cell Sci. 2009;122:3780-90 pubmed publisher
    X-linked recessive Emery-Dreifuss muscular dystrophy (EDMD) is caused by loss of emerin, a nuclear-membrane protein with roles in nuclear architecture, gene regulation and signaling...
  19. Farina A, Santarelli R, Bloise R, Gonnella R, Granato M, Bei R, et al. KSHV ORF67 encoded lytic protein localizes on the nuclear membrane and alters emerin distribution. Virus Res. 2013;175:143-50 pubmed publisher
    ..of infected or transfected cells showed that p29 expression resulted in delocalization and hyperphosphorylation of emerin, whereas other nuclear lamin associated proteins, such as LUMA, LB1 and LBR were not affected...
  20. Sakaki M, Koike H, Takahashi N, Sasagawa N, Tomioka S, Arahata K, et al. Interaction between emerin and nuclear lamins. J Biochem. 2001;129:321-7 pubmed
    b>Emerin is an inner nuclear membrane protein that is involved in X-linked recessive Emery-Dreifuss muscular dystrophy (X-EDMD)...
  21. Mansharamani M, Wilson K. Direct binding of nuclear membrane protein MAN1 to emerin in vitro and two modes of binding to barrier-to-autointegration factor. J Biol Chem. 2005;280:13863-70 pubmed
    ..Many regions of human MAN1 are homologous to emerin, a LEM domain nuclear protein, loss of which causes Emery-Dreifuss muscular dystrophy (EDMD)...
  22. Holaska J, Lee K, Kowalski A, Wilson K. Transcriptional repressor germ cell-less (GCL) and barrier to autointegration factor (BAF) compete for binding to emerin in vitro. J Biol Chem. 2003;278:6969-75 pubmed
    b>Emerin belongs to the "LEM domain" family of nuclear proteins, which contain a characteristic approximately 40-residue LEM motif...
  23. Rowat A, Lammerding J, Ipsen J. Mechanical properties of the cell nucleus and the effect of emerin deficiency. Biophys J. 2006;91:4649-64 pubmed
    ..envelope stability in disease and found that mouse embryo fibroblasts lacking the inner nuclear membrane protein, emerin, had a significantly decreased ratio of the area expansion to shear moduli (K/mu) compared to wild-type cells (2...
  24. Wilkinson F, Holaska J, Zhang Z, Sharma A, Manilal S, Holt I, et al. Emerin interacts in vitro with the splicing-associated factor, YT521-B. Eur J Biochem. 2003;270:2459-66 pubmed
    b>Emerin is a nuclear membrane protein that interacts with lamin A/C at the nuclear envelope. Mutations in either emerin or lamin A/C cause Emery-Dreifuss muscular dystrophy (EDMD)...
  25. Meyer A, Almendrala D, Go M, Krauss S. Structural protein 4.1R is integrally involved in nuclear envelope protein localization, centrosome-nucleus association and transcriptional signaling. J Cell Sci. 2011;124:1433-44 pubmed publisher
    ..Here we show that 4.1R, the nuclear envelope protein emerin and the intermediate filament protein lamin A/C co-immunoprecipitate, and that 4...
  26. Hirano Y, Segawa M, Ouchi F, Yamakawa Y, Furukawa K, Takeyasu K, et al. Dissociation of emerin from barrier-to-autointegration factor is regulated through mitotic phosphorylation of emerin in a xenopus egg cell-free system. J Biol Chem. 2005;280:39925-33 pubmed
    b>Emerin is the gene product of STA whose mutations cause Emery-Dreifuss muscular dystrophy. It is an inner nuclear membrane protein and phosphorylated in a cell cycle-dependent manner...
  27. Hausmanowa Petrusewicz I, Madej Pilarczyk A, Marchel M, Opolski G. Emery-Dreifuss dystrophy: a 4-year follow-up on a laminopathy of special interest. Neurol Neurochir Pol. 2009;43:415-20 pubmed
    The authors present the results of a 4-year follow-up of patients with Emery-Dreifuss dystrophy (EDMD) included in a project on laminopathies...
  28. Ellis J, Craxton M, Yates J, Kendrick Jones J. Aberrant intracellular targeting and cell cycle-dependent phosphorylation of emerin contribute to the Emery-Dreifuss muscular dystrophy phenotype. J Cell Sci. 1998;111 ( Pt 6):781-92 pubmed
    The product of the X-linked Emery-Dreifuss muscular dystrophy gene is a protein called emerin, which is localized to the nuclear membrane...
  29. Haraguchi T, Holaska J, Yamane M, Koujin T, Hashiguchi N, Mori C, et al. Emerin binding to Btf, a death-promoting transcriptional repressor, is disrupted by a missense mutation that causes Emery-Dreifuss muscular dystrophy. Eur J Biochem. 2004;271:1035-45 pubmed
    Loss of functional emerin, a nuclear membrane protein, causes X-linked recessive Emery-Dreifuss muscular dystrophy...
  30. Clements L, Manilal S, Love D, Morris G. Direct interaction between emerin and lamin A. Biochem Biophys Res Commun. 2000;267:709-14 pubmed
    b>Emerin is the protein of the inner nuclear membrane that is affected by mutation in X-linked Emery-Dreifuss muscular dystrophy. The autosomal dominant form of the disease is caused by mutations in the lamin A/C gene...
  31. Jaffer I, Chan N, Roberts R, Fredenburgh J, Eikelboom J, Weitz J. Comparison of the ecarin chromogenic assay and diluted thrombin time for quantification of dabigatran concentrations. J Thromb Haemost. 2017;: pubmed publisher
    ..We compared ecarin chromogenic assay (STA-ECA-II) and dilute thrombin time (dTT) in patient samples...
  32. Hodgson R, Walton M, Biswas M, Mebrahtu T, Woolacott N. Ustekinumab for Treating Moderately to Severely Active Crohn's Disease after Prior Therapy: An Evidence Review Group Perspective of a NICE Single Technology Appraisal. Pharmacoeconomics. 2018;36:387-398 pubmed publisher
    As part of the single technology appraisal (STA) process, the National Institute for Health and Care Excellence (NICE) invited Janssen to submit evidence on the clinical and cost effectiveness of their drug ustekinumab, an interleukin-12/..
  33. Seshima F, Aoki H, Takeuchi T, Suzuki E, Irokawa D, Makino Oi A, et al. Periodontal regenerative therapy with enamel matrix derivative in the treatment of intrabony defects: a prospective 2-year study. BMC Res Notes. 2017;10:256 pubmed publisher
    ..In this population of patients, the treatment of intrabony defects with EMD yielded clinically favorable outcomes, as assessed by periodontal and radiographical parameters, over a period of 2 years. ..
  34. Abe H, Katsuta T, Miki K, Higashi T, Inoue T. Temporary Steno-occlusive Change in the Donor Artery During Mouth Opening (Big Bite Ischemic Phenomenon) After Superficial Temporal Artery to Middle Cerebral Artery Bypass in Adult Patients with Moyamoya Disease and Atherosclerosis. Acta Neurochir Suppl. 2016;123:123-8 pubmed publisher
    Superficial temporal artery (STA) to middle cerebral artery (MCA) bypass is one of the most common surgical procedures performed for direct extracranial (EC) to intracranial (IC) bypasses...
  35. Smith C, Housh T, Hill E, Keller J, Johnson G, Schmidt R. Are there mode-specific and fatigue-related electromechanical delay responses for maximal isokinetic and isometric muscle actions?. J Electromyogr Kinesiol. 2017;37:9-14 pubmed publisher
    ..There were, however, fatigue-induced pretest to posttest increases in EMDE-M, EMDM-F, and EMDE-F which remained elongated after 3-min of recovery, but returned to pretest values after 5-min of recovery. ..
  36. Niu K, Anijs T, Sluiter V, Homminga J, Sprengers A, Marra M, et al. In situ comparison of A-mode ultrasound tracking system and skin-mounted markers for measuring kinematics of the lower extremity. J Biomech. 2018;72:134-143 pubmed publisher
    ..Kinematic measurements associated with skin-mounted markers are subject to soft tissue artifacts (STA), since the markers follow skin movement, thus generating errors when used to represent motions of underlying bone ..
  37. Meaburn K, Levy N, Toniolo D, Bridger J. Chromosome positioning is largely unaffected in lymphoblastoid cell lines containing emerin or A-type lamin mutations. Biochem Soc Trans. 2005;33:1438-40 pubmed
    ..g. emerin and A-type lamins...
  38. Martins S, Eide T, Steen R, Jahnsen T, Skålhegg B S, Collas P. HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics. J Cell Sci. 2000;113 Pt 21:3703-13 pubmed
    ..HA95 resides in a complex together with lamin B receptor (LBR), lamina-associated polypeptide (LAP)2 and emerin, integral proteins of the inner nuclear membrane...
  39. Aimetti M, Ferrarotti F, Mariani G, Romano F. A novel flapless approach versus minimally invasive surgery in periodontal regeneration with enamel matrix derivative proteins: a 24-month randomized controlled clinical trial. Clin Oral Investig. 2017;21:327-337 pubmed publisher
    ..The use of EMD as an adjunct to non-surgical periodontal treatment may be considered a suitable option to treat defects mainly in the anterior sextants. ..
  40. Rausch D, Ruan X, Nandre R, Duan Q, Hashish E, Casey T, et al. Antibodies derived from a toxoid MEFA (multiepitope fusion antigen) show neutralizing activities against heat-labile toxin (LT), heat-stable toxins (STa, STb), and Shiga toxin 2e (Stx2e) of porcine enterotoxigenic Escherichia coli (ETEC). Vet Microbiol. 2017;202:79-89 pubmed publisher
    ..ETEC enterotoxins including heat-labile toxin (LT) and heat-stable toxins type Ia (porcine-type STa) and type II (STb) stimulate fluid hyper-secretion, leading to watery diarrhea...
  41. de Vilmorin P, Slocum A, Jaber T, Schaefer O, Ruppach H, Genest P. Achieving a Successful Scale-Down Model and Optimized Economics through Parvovirus Filter Validation using Purified TrueSpikeTM Viruses. PDA J Pharm Sci Technol. 2015;69:440-9 pubmed publisher
    ..This article describes how improvements in mammalian virus spike purity ensure the validity of the log reduction value obtained with the scale-down model and support economically optimized filter usage. ..
  42. Mikami K, Medová M, Nisa L, Francica P, Glück A, Tschan M, et al. Impact of p53 Status on Radiosensitization of Tumor Cells by MET Inhibition-Associated Checkpoint Abrogation. Mol Cancer Res. 2015;13:1544-53 pubmed publisher
    ..The current data point for a therapeutic advantage for an approach combining MET targeting along with DNA-damaging agents for MET-positive/p53-negative tumors. ..
  43. Menovsky T, Sener S, Kamerling N, Plazier M, Boogaarts J, Lukes A. Preservation and Microsurgical Repair of the Superficial Temporal Artery During Pterional Craniotomy. World Neurosurg. 2016;89:72-7 pubmed publisher
    To study the rate of superficial temporal artery (STA) preservation and the effectiveness of STA reconstruction in patients undergoing a pterional craniotomy...
  44. Jacque J, Stevenson M. The inner-nuclear-envelope protein emerin regulates HIV-1 infectivity. Nature. 2006;441:641-5 pubmed
    ..Here we show that emerin, an integral inner-nuclear-envelope protein, is necessary for HIV-1 infection...
  45. Accardo A, Galli F, Mansi R, Del Pozzo L, Aurilio M, Morisco A, et al. Pre-clinical evaluation of eight DOTA coupled gastrin-releasing peptide receptor (GRP-R) ligands for in vivo targeting of receptor-expressing tumors. EJNMMI Res. 2016;6:17 pubmed publisher
    ..The BN8 compound (DOTA-PEG-DPhe-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH2) showed high affinity, the longest serum stability, and the highest target-to-background ratios in ..
  46. Clément J, Dumas R, Hagemeister N, de Guise J. Soft tissue artifact compensation in knee kinematics by multi-body optimization: Performance of subject-specific knee joint models. J Biomech. 2015;48:3796-802 pubmed publisher
    Soft tissue artifact (STA) distort marker-based knee kinematics measures and make them difficult to use in clinical practice...
  47. Waitschat S, Wharmby M, Stock N. Flow-synthesis of carboxylate and phosphonate based metal-organic frameworks under non-solvothermal reaction conditions. Dalton Trans. 2015;44:11235-40 pubmed publisher
    ..Synthesis of the aluminium carboxylate CAU-13 was also performed, to demonstrate the versatility of the device. Finally the reactor was used to synthesise a new cadmium phosphonate framework, bearing the STA-12 network.
  48. Jafferali M, Figueroa R, Hasan M, Hallberg E. Spindle associated membrane protein 1 (Samp1) is required for the differentiation of muscle cells. Sci Rep. 2017;7:16655 pubmed publisher
    ..Samp1 (Spindle Associated Membrane Protein 1), a transmembrane nuclear envelope protein, which interacts with emerin and lamin A, both of which are linked to Emery-Dreifuss muscular dystrophy (EDMD)...
  49. Campanella V, Libonati A, Nardi R, Angotti V, Gallusi G, Montemurro E, et al. Single tooth anesthesia versus conventional anesthesia: a cross-over study. Clin Oral Investig. 2018;22:3205-3213 pubmed publisher
    ..served as his/her own control being subject to two anesthesia techniques: conventional and Single Tooth Anesthesia (STA) performed with the Wand...
  50. Rockenfeller R, Gunther M. Extracting low-velocity concentric and eccentric dynamic muscle properties from isometric contraction experiments. Math Biosci. 2016;278:77-93 pubmed publisher
    ..Fourth, because of an inconsistency in literature, we developed a simple method to determine switching times of the neural stimulation and thus electro-mechanical delay (EMD) values from measuring muscle force in ICEs only. ..
  51. Xu Y, Luo M, Li T, Song G. ECG Signal De-noising and Baseline Wander Correction Based on CEEMDAN and Wavelet Threshold. Sensors (Basel). 2017;17: pubmed publisher
  52. Sangeux M, Barré A, Aminian K. Evaluation of knee functional calibration with and without the effect of soft tissue artefact. J Biomech. 2017;62:53-59 pubmed publisher
    ..of thigh and shank marker clusters were captured simultaneously to investigate the effect of soft tissue artefact (STA)...
  53. Yadav S, Libotte F, Buono E, Valia S, Farina G, Faggioni A, et al. EBV early lytic protein BFRF1 alters emerin distribution and post-translational modification. Virus Res. 2017;232:113-122 pubmed publisher
    ..Here we show that EBV replication causes the delocalization of emerin, a cellular LEM-domain protein normally distributed on the nuclear rim...
  54. Herlan S, Roser F, Ebner F, Tatagiba M. The midline suboccipital subtonsillar approach to the cerebellomedullary cistern: how I do it. Acta Neurochir (Wien). 2017;159:1613-1617 pubmed publisher
    ..To gain access to this area, we use the midline suboccipital subtonsillar approach (STA)...
  55. Wang C, Kemao Q, Da F. Automatic fringe enhancement with novel bidimensional sinusoids-assisted empirical mode decomposition. Opt Express. 2017;25:24299-24311 pubmed publisher
    ..A series of experiments show that the proposed method is accurate, efficient and robust to various fringe patterns even with poor quality, rendering it a potential tool for practical use...
  56. Solayar G, Chinappa J, Harris I, Chen D, Macdessi S. A Comparison of Plain Radiography with Computer Tomography in Determining Coronal and Sagittal Alignments following Total Knee Arthroplasty. Malays Orthop J. 2017;11:45-52 pubmed publisher
    ..Hip-knee-angle (HKA), sagittal femoral angle (SFA) and sagittal tibial angle (STA) measurements were taken by two observers from plain radiographs and compared with CT alignment...
  57. Fan J, Yu L, Zhao J. Comparative transcriptome analysis reveals involvement of TLR-2 signaling in the pathogenesis of intracranial aneurysm. J Clin Neurosci. 2018;47:258-263 pubmed publisher
    In this study, we collected and analyzed 15 aneurysmal and 17 superficial temporal artery (STA) specimens from 32 Chinese patients with intracranial aneurysm...
  58. Alekseev A, Pichugin A, Danilov V. [A supraorbital trans-eyebrow approach in surgery of chiasmatic-sellar and anterior cranial fossa tumors]. Zh Vopr Neirokhir Im N N Burdenko. 2017;81:36-45 pubmed publisher
    to analyze 31 resections of chiasmatic-sellar region (CSR) and anterior cranial fossa (ACF) tumors using the supraorbital trans-eyebrow approach (STA).
  59. De Leo V, Cappelli V, Morgante G, Di Sabatino A. [The role of vitamin D in assisted reproduction techniques]. Minerva Ginecol. 2018;70:268-285 pubmed publisher
    ..Over the last few years, vitamin D has been suggested to have a role in assisted reproduction techniques. ..
  60. Yamada T, Kobayashi T. A novel emerin mutation in a Japanese patient with Emery-Dreifuss muscular dystrophy. Hum Genet. 1996;97:693-4 pubmed
    Sequencing of the STA gene in a patient with Emery-Dreifuss muscular dystrophy showed a 1-bp deletion of C at nucleotide 672 or 673...
  61. Muchir A, Massart C, van Engelen B, Lammens M, Bonne G, Worman H. Proteasome-mediated degradation of integral inner nuclear membrane protein emerin in fibroblasts lacking A-type lamins. Biochem Biophys Res Commun. 2006;351:1011-7 pubmed
    ..nonsense mutation, there was a decreased steady-state expression of the integral inner nuclear membrane proteins emerin and nesprin-1alpha associated with their mislocalization to the bulk endoplasmic reticulum and a ..
  62. Jin Z, Xu C, Duan W, Yang J, Tian P. [The level of IL-2 and IL-6 in stimulated peripheral lymphocyte supernatants of kidney transplant recipients can predict acute renal allograft rejection]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017;33:1024-1029 pubmed
    ..52 kidney transplant recipients, including 22 ones with acute rejection (AR) and 30 with stable allograft function (STA)...
  63. Arikawa H, Matsumoto K, Fujiki T. Polyhydroxyalkanoate production from sucrose by Cupriavidus necator strains harboring csc genes from Escherichia coli W. Appl Microbiol Biotechnol. 2017;101:7497-7507 pubmed publisher
    ..5-fold higher than that produced using glucose solution. ..
  64. Amine K, El Amrani Y, Chemlali S, Kissa J. Alternatives to connective tissue graft in the treatment of localized gingival recessions: A systematic review. J Stomatol Oral Maxillofac Surg. 2017;: pubmed publisher
    ..The comparison between PRF and others technique was affected by large uncertainty. ADM, XCM and EMD assisted to CAF might be considered alternatives of CTG in the treatment of Miller class I and II gingival recession. ..
  65. Park C, Oh J, Jung H, Choi Y, Rahman S, Kim S, et al. Effects of the incorporation of ε-aminocaproic acid/chitosan particles to fibrin on cementoblast differentiation and cementum regeneration. Acta Biomater. 2017;61:134-143 pubmed publisher
    ..Furthermore, the modified fibrin could improve repair and regeneration of tooth roof-of-furcation defects, which has spatial curvatures and geometrical difficulties and hardly regenerates periodontal tissues. ..
  66. Yi Zhang -, Su S, Peng Xu -, Dezhong Yao -. Performance evaluation of Noise-Assisted Multivariate Empirical Mode Decomposition and its application to multichannel EMG signals. Conf Proc IEEE Eng Med Biol Soc. 2017;2017:3457-3460 pubmed publisher
    ..It has a vital clinical implication in exploring the neuromuscular patterns that enable the multiple muscle groups to coordinate while performing functional activities of daily living...
  67. Duan Q, Huang J, Xiao N, Seo H, Zhang W. Neutralizing Anti-Heat-Stable Toxin (STa) Antibodies Derived from Enterotoxigenic Escherichia coli Toxoid Fusions with STa Proteins Containing N12S, L9A/N12S, or N12S/A14T Mutations Show Little Cross-Reactivity with Guanylin or Uroguanylin. Appl Environ Microbiol. 2018;84: pubmed publisher
    Heat-stable toxin (STa)-producing enterotoxigenic Escherichia coli (ETEC) strains are a top cause of moderate-to-severe diarrhea in children from developing countries and a common cause of travelers' diarrhea...
  68. Li P, Meinke P, Huong L, Wehnert M, Noegel A. Contribution of SUN1 mutations to the pathomechanism in muscular dystrophies. Hum Mutat. 2014;35:452-61 pubmed publisher
    ..We analyzed fibroblasts from a patient who had a mutation in the EMD gene (p.L84Pfs*6) leading to loss of Emerin and a heterozygous mutation in SUN1 (p.A203V). The second patient harbored a heterozygous mutation in LAP2alpha (p...
  69. Helbling Leclerc A, Bonne G, Schwartz K. Emery-Dreifuss muscular dystrophy. Eur J Hum Genet. 2002;10:157-61 pubmed
    ..The genes known to be responsible for EDMD encode proteins associated with the nuclear envelope: the emerin and the lamins A and C.
  70. Kimura T, Morita A. Occipital Artery to Middle Cerebral Artery Bypass: Operative Nuances. World Neurosurg. 2017;108:201-205 pubmed publisher
    Superficial temporal artery (STA)-middle cerebral artery (MCA) anastomosis is a common procedure for vascular neurosurgeons, and it is used in a variety of diseases...
  71. Wang Y, Yamaguchi H, Huo L, Du Y, Lee H, Lee H, et al. The translocon Sec61beta localized in the inner nuclear membrane transports membrane-embedded EGF receptor to the nucleus. J Biol Chem. 2010;285:38720-9 pubmed publisher
    ..The newly identified Sec61? function provides an alternative pathway for nuclear transport that can be utilized by membrane-embedded proteins such as full-length EGFR. ..
  72. Collins C, Ellis J, Holaska J. MAPK signaling pathways and HDAC3 activity are disrupted during differentiation of emerin-null myogenic progenitor cells. Dis Model Mech. 2017;10:385-397 pubmed publisher
    Mutations in the gene encoding emerin cause Emery-Dreifuss muscular dystrophy (EDMD). Emerin is an integral inner nuclear membrane protein and a component of the nuclear lamina...
  73. Nandre R, Duan Q, Wang Y, Zhang W. Passive antibodies derived from intramuscularly immunized toxoid fusion 3xSTaN12S-dmLT protect against STa+ enterotoxigenic Escherichia coli (ETEC) diarrhea in a pig model. Vaccine. 2017;35:552-556 pubmed publisher
    ..ETEC heat-labile toxin (LT) and heat-stable toxin (STa) toxoid fusion 3xSTaN12S-dmLT was demonstrated recently to induce neutralizing antitoxin antibodies in ..
  74. Berk J, Simon D, Jenkins Houk C, Westerbeck J, Grønning Wang L, Carlson C, et al. The molecular basis of emerin-emerin and emerin-BAF interactions. J Cell Sci. 2014;127:3956-69 pubmed publisher
    b>Emerin is a conserved membrane component of nuclear lamina structure. Here, we report an advance in understanding the molecular basis of emerin function: intermolecular emerin-emerin association...
  75. Rudenskaia G, Tverskaia S, Chukhrova A, Zakliaz minskaia E, Kuropatkina I, Dadali E, et al. [Clinical, genealogical and molecular genetic study of Emery-Dreifuss muscular dystrophy]. Zh Nevrol Psikhiatr Im S S Korsakova. 2006;106:58-65 pubmed
    A search for emerin and lamin A/C (LMNA) mutations was performed in a group of 63 unrelated patients with probable Emery-Dreifuss muscular dystrophy (EDMD) and other MD's with concomitant dilated cardiomyopathy (DCMP)...
  76. Ju W, Brown W, Zhong N. Association of progerin-interactive partner proteins with lamina proteins: Mel18 is associated with emerin in HGPS. Beijing Da Xue Xue Bao Yi Xue Ban. 2009;41:397-401 pubmed
    ..An association of Mel18 with emerin was observed in HGPS, but not in WT cells...