ELOVL5

Summary

Gene Symbol: ELOVL5
Description: ELOVL fatty acid elongase 5
Alias: HELO1, SCA38, dJ483K16.1, elongation of very long chain fatty acids protein 5, 3-keto acyl-CoA synthase ELOVL5, ELOVL FA elongase 5, ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast), fatty acid elongase 1, homolog of yeast long chain polyunsaturated fatty acid elongation enzyme 2, spinocerebellar ataxia 38, very long chain 3-ketoacyl-CoA synthase 5, very long chain 3-oxoacyl-CoA synthase 5
Species: human
Products:     ELOVL5

Top Publications

  1. Barragan I, Marcos I, Borrego S, Antinolo G. Mutation screening of three candidate genes, ELOVL5, SMAP1 and GLULD1 in autosomal recessive retinitis pigmentosa. Int J Mol Med. 2005;16:1163-7 pubmed
    ..b>ELOVL5, SMAP1 and GLULD1 were selected on the basis of their location, tissue expression and/or function...
  2. Leonard A, Kelder B, Bobik E, Chuang L, Lewis C, Kopchick J, et al. Identification and expression of mammalian long-chain PUFA elongation enzymes. Lipids. 2002;37:733-40 pubmed
    ..Biophys. Acta 1486, 219-231, 2000). We searched the database using the translated sequence of human elongase ELOVL5, whose encoded enzyme elongates monounsaturated and polyunsaturated FA, as a query to identify the enzyme(s) ..
  3. Morales E, Bustamante M, Gonzalez J, Guxens M, Torrent M, Mendez M, et al. Genetic variants of the FADS gene cluster and ELOVL gene family, colostrums LC-PUFA levels, breastfeeding, and child cognition. PLoS ONE. 2011;6:e17181 pubmed publisher
    ..Tag SNPs were genotyped both in mothers and children (13 in the FADS cluster, 6 in ELOVL2, and 7 in ELOVL5)...
  4. Aragón Herrera A, Feijóo Bandín S, Abella V, Alvarez L, Roselló Lletí E, Portolés M, et al. Serelaxin (recombinant human relaxin-2) treatment affects the endogenous synthesis of long chain poly-unsaturated fatty acids and induces substantial alterations of lipidome and metabolome profiles in rat cardiac tissue. Pharmacol Res. 2019;144:51-65 pubmed publisher
    ..Atrial levels of Elovl5 (Elongation of very long chain fatty acids protein 5), Fads1 (Δ5-fatty acid desaturase) and Fads2 (Δ6-fatty acid desaturase), key enzymes of ..
  5. Kanemaki N, Tchedre K, Imayasu M, Kawarai S, Sakaguchi M, Yoshino A, et al. Dogs and humans share a common susceptibility gene SRBD1 for glaucoma risk. PLoS ONE. 2013;8:e74372 pubmed publisher
    ..In this study, we investigated the association between polymorphisms of the glaucoma candidate genes, SRBD1, ELOVL5, and ADAMTS10, and glaucoma in Shiba-Inus and Shih-Tzus...
  6. Shkurnikov M, Poloznikov A, Nikulin S, Schumacher U, Wicklein D, Stürken C, et al. Transcriptome Guided Drug Combination Suppresses Proliferation of Breast Cancer Cells. Bull Exp Biol Med. 2019;166:656-660 pubmed publisher
    ..We have previously detected two molecular markers of relapses in patients with malignant breast tumors: ELOVL5 and IGFBP6. Poor prognosis is associated with low expression of these markers...
  7. Nielsen B, Gøtterup L, Jørgensen T, Hansen B, Hansen L, Mortensen J, et al. n-3 PUFA biosynthesis by the copepod Apocyclops royi documented using fatty acid profile analysis and gene expression analysis. Biol Open. 2019;8: pubmed publisher
    ..Transcripts correlating to the four enzymes Elovl4, Elovl5, Fad Δ5 and Fad Δ6 in the n-3 PUFA biosynthetic pathway were identified...
  8. Zou W, Lin Z, Huang Y, Limbu S, Wen X. Molecular cloning and functional characterization of elongase (elovl5) and fatty acyl desaturase (fads2) in sciaenid, Nibea diacanthus (Lacepède, 1802). Gene. 2019;695:1-11 pubmed publisher
    ..The elongase cDNA sequence encoded a polypeptide of 294 amino acids exhibiting Elovl5 activity, which effectively elongated both C18 (18:2n-6, 18:3n-3 and 18:3n-6) and C20 (20:4n-6 and 20:5n-3) ..
  9. Shmarakov I, Jiang H, Liu J, Fernandez E, Blaner W. Hepatic stellate cell activation: A source for bioactive lipids. Biochim Biophys Acta Mol Cell Biol Lipids. 2019;1864:629-642 pubmed publisher
    ..HSCs along with an upregulation of transcription of fatty acid desaturases (Scd1, Scd2) and elongases (Elovl5, Elovl6)...

More Information

Publications90

  1. Carmona Antoñanzas G, Tocher D, Taggart J, Leaver M. An evolutionary perspective on Elovl5 fatty acid elongase: comparison of Northern pike and duplicated paralogs from Atlantic salmon. BMC Evol Biol. 2013;13:85 pubmed publisher
    ..Here we characterise a pike fatty acyl elongase, elovl5, and compare it to Atlantic salmon elovl5a and elovl5b duplicates...
  2. Liao K, Ran Z, Meng R, Xu J, Cao J, Xu X, et al. Long-chain polyunsaturated fatty acid biosynthesis and its response to cadmium exposure in silver pomfret. Aquat Toxicol. 2019;206:61-71 pubmed publisher
    ..Our results showed that fatty acyl desaturase 2 (Fads2) and elongases of very long-chain fatty acids 5 (Elovl5), two key enzymes involved in LC-PUFA biosynthesis, enabled silver pomfret to biosynthesize 20:3n-6 and 20:4n-3 ..
  3. Li Y, Zeng X, Dong Y, Chen C, You C, Tang G, et al. Hnf4α Is Involved in LC-PUFA Biosynthesis by Up-Regulating Gene Transcription of Elongase in Marine Teleost Siganus canaliculatus. Int J Mol Sci. 2018;19: pubmed publisher
    ..by two fatty acyl desaturases (fad) including Δ4 Fad and Δ6/Δ5 Fad as well as two elongases (Elovl4 and Elovl5)...
  4. Cormier H, Rudkowska I, Lemieux S, Couture P, Julien P, Vohl M. Effects of FADS and ELOVL polymorphisms on indexes of desaturase and elongase activities: results from a pre-post fish oil supplementation. Genes Nutr. 2014;9:437 pubmed publisher
    ..Twenty-eight SNPs from FADS1, FADS2, FADS3, ELOVL2 and ELOVL5 were genotyped using TaqMan technology...
  5. Machado A, Tørresen O, Kabeya N, Couto A, Petersen B, Felício M, et al. "Out of the Can": A Draft Genome Assembly, Liver Transcriptome, and Nutrigenomics of the European Sardine, Sardina pilchardus. Genes (Basel). 2018;9: pubmed publisher
    ..a proof of principle of the value of this dataset, we established the presence and function of enzymes (Elovl2, Elovl5, and Fads2) that have pivotal roles in the biosynthesis of long chain polyunsaturated fatty acids, essential ..
  6. Rodriguez Cruz M, Sánchez González R, Sánchez García A, López Alarcón M. Coexisting role of fasting or feeding and dietary lipids in the control of gene expression of enzymes involved in the synthesis of saturated, monounsaturated and polyunsaturated fatty acids. Gene. 2012;496:28-36 pubmed publisher
    ..A higher content of LC-PUFAs was observed due to a high expression of Elovl2 and Elovl5, although Fads2 was suppressed by dietary lipids...
  7. Hwang J, Lee H, Go M, Jang H, Choi N, Bae J, et al. Genome-wide methylation analysis identifies ELOVL5 as an epigenetic biomarker for the risk of type 2 diabetes mellitus. Sci Rep. 2018;8:14862 pubmed publisher
    ..external validation, we replicated the T2D-association at a novel CpG signal in the ELOVL fatty acid elongase 5 (ELOVL5) gene specific to T2D-discordant MZTW...
  8. Robichaud P, Munganyiki J, Boilard E, Surette M. Polyunsaturated fatty acid elongation and desaturation in activated human T-cells: ELOVL5 is the key elongase. J Lipid Res. 2018;59:2383-2396 pubmed publisher
    ..No quantifiable ELOVL2 was measured. Knockdown of ELOVL5 in T-cells and Jurkat cells significantly affected cellular monounsaturated and PUFA profiles and strongly ..
  9. Song Y, Luo Z, Pan Y, Zhang L, Chen Q, Zheng J. Three unsaturated fatty acid biosynthesis-related genes in yellow catfish Pelteobagrus fulvidraco: Molecular characterization, tissue expression and transcriptional regulation by leptin. Gene. 2015;563:1-9 pubmed publisher
    ..desaturase-1 (SCD1), Δ6 fatty acyl desaturases (Fads2 (Δ6)) and elongase of very long-chain fatty acid 5 (ELOVL5) were firstly isolated and characterized from yellow catfish, Pelteobagrus fulvidraco...
  10. Mabuchi F, Sakurada Y, Kashiwagi K, Yamagata Z, Iijima H, Tsukahara S. Involvement of genetic variants associated with primary open-angle glaucoma in pathogenic mechanisms and family history of glaucoma. Am J Ophthalmol. 2015;159:437-44.e2 pubmed publisher
    ..191 control subjects were genotyped for 5 non-IOP-related genetic variants predisposing to POAG near the SRBD1, ELOVL5, CDKN2B/CDKN2B-AS1, SIX1/SIX6, and ATOH7 genes...
  11. Hoile S, Clarke Harris R, Huang R, Calder P, Mori T, Beilin L, et al. Supplementation with N-3 long-chain polyunsaturated fatty acids or olive oil in men and women with renal disease induces differential changes in the DNA methylation of FADS2 and ELOVL5 in peripheral blood mononuclear cells. PLoS ONE. 2014;9:e109896 pubmed publisher
    ..in methylation) 2/22 fatty acid desaturase (FADS)-2 CpGs, while n-3 LCPUFA, but not OO, altered (>10%) 1/12 ELOVL5 CpGs in men...
  12. Ferraz R, Kabeya N, Lopes Marques M, Machado A, Ribeiro R, Salaro A, et al. A complete enzymatic capacity for long-chain polyunsaturated fatty acid biosynthesis is present in the Amazonian teleost tambaqui, Colossoma macropomum. Comp Biochem Physiol B Biochem Mol Biol. 2019;227:90-97 pubmed publisher
    ..aimed at cloning and functionally characterizing genes encoding key desaturase and elongase enzymes, namely fads2, elovl5 and elovl2, involved in the LC-PUFA biosynthetic pathways in tambaqui...
  13. Kuah M, Jaya Ram A, Shu Chien A. A fatty acyl desaturase (fads2) with dual Δ6 and Δ5 activities from the freshwater carnivorous striped snakehead Channa striata. Comp Biochem Physiol A Mol Integr Physiol. 2016;201:146-155 pubmed publisher
    ..of Δ6/Δ5 Fads2 desaturase here complements the previous discovery of a Δ4 Fads2 desaturase and an Elovl5 elongase, lending proof to the existence of all the required enzymatic machinery to biosynthesise LC-PUFA from C18 ..
  14. Gregory M, James M. Rainbow trout (Oncorhynchus mykiss) Elov15 and Elov12 differ in selectivity for elongation of omega-3 docosapentaenoic acid. Biochim Biophys Acta. 2014;1841:1656-60 pubmed
    ..study is the first to identify an Elov12 in rainbow trout (Oncorhynchus mykiss) and functionally chafacterise the Elovl5 and Elovl2 using a yeast expression system. Elovl5 was active with C18-20 PUFA substrates and not C22 PUFA...
  15. Kuah M, Jaya Ram A, Shu Chien A. The capacity for long-chain polyunsaturated fatty acid synthesis in a carnivorous vertebrate: Functional characterisation and nutritional regulation of a Fads2 fatty acyl desaturase with Δ4 activity and an Elovl5 elongase in striped snakehead (Channa. Biochim Biophys Acta. 2015;1851:248-60 pubmed publisher
    ..is capable of Δ4 and Δ5 desaturation activities, while the elongase showed the characteristics of Elovl5 elongases...
  16. Morais S, Mourente G, Martínez A, Gras N, Tocher D. Docosahexaenoic acid biosynthesis via fatty acyl elongase and Δ4-desaturase and its modulation by dietary lipid level and fatty acid composition in a marine vertebrate. Biochim Biophys Acta. 2015;1851:588-97 pubmed publisher
    ..Fatty acyl elongation (Elovl5) and desaturation (Δ4Fad) activities were measured in isolated enterocytes and hepatocytes incubated with ..
  17. Xue X, Hixson S, Hori T, Booman M, Parrish C, Anderson D, et al. Atlantic salmon (Salmo salar) liver transcriptome response to diets containing Camelina sativa products. Comp Biochem Physiol Part D Genomics Proteomics. 2015;14:1-15 pubmed publisher
    ..btg1, dnph1, lect-2, clra, klf9, and fadsd6a], and three additional genes involved in lipid metabolism [elovl2, elovl5 (2 paralogues), and fadsd5], were subjected to QPCR with liver templates from all 5 dietary treatments...
  18. Weitkunat K, Schumann S, Petzke K, Blaut M, Loh G, Klaus S. Effects of dietary inulin on bacterial growth, short-chain fatty acid production and hepatic lipid metabolism in gnotobiotic mice. J Nutr Biochem. 2015;26:929-37 pubmed publisher
    ..of genes involved in lipogenesis (Fasn, Gpam) and fatty acid elongation/desaturation (Scd1, Elovl3, Elovl6, Elovl5, Fads1 and Fads2) were decreased in inulin-fed animals...
  19. Li S, Monroig O, Wang T, Yuan Y, Carlos Navarro J, Hontoria F, et al. Functional characterization and differential nutritional regulation of putative Elovl5 and Elovl4 elongases in large yellow croaker (Larimichthys crocea). Sci Rep. 2017;7:2303 pubmed publisher
    In the present study, two elongases, Elovl4 and Elovl5, were functionally characterized and their transcriptional regulation in response to n-3 LC-PUFA administration were investigated in vivo and in vitro...
  20. Santiago Valtierra F, Peñalva D, Luquez J, Furland N, Vásquez C, Reyes J, et al. Elovl4 and Fa2h expression during rat spermatogenesis: a link to the very-long-chain PUFAs typical of germ cell sphingolipids. J Lipid Res. 2018;59:1175-1189 pubmed publisher
    ..Along with Elovl5 and Elovl2, Elovl4 was actively transcribed in the adult testis...
  21. Chen C, Zhang J, Zhang M, You C, Liu Y, Wang S, et al. miR-146a is involved in the regulation of vertebrate LC-PUFA biosynthesis by targeting elovl5 as demonstrated in rabbitfish Siganus canaliculatus. Gene. 2018;676:306-314 pubmed publisher
    ..The expression of miR-146a displayed an inverse pattern with that of elongase 5 (Elovl5), a key enzyme catalyzing the elongation of C18 (18:4n3 and 18:3n6) and C20 (20:5n3 and 20:..
  22. Shi H, Du Y, Zhang C, Sun C, He Y, Wu Y, et al. Fatty acid elongase 5 (ELOVL5) alters the synthesis of long-chain unsaturated fatty acids in goat mammary epithelial cells. J Dairy Sci. 2018;101:4586-4594 pubmed publisher
    ..In nonruminant species, fatty acid elongase 5 (ELOVL5) is a key enzyme for endogenous synthesis of long-chain unsaturated fatty acids...
  23. Zhu B, Niu H, Zhang W, Wang Z, Liang Y, Guan L, et al. Genome wide association study and genomic prediction for fatty acid composition in Chinese Simmental beef cattle using high density SNP array. BMC Genomics. 2017;18:464 pubmed publisher
    ..obtained several candidate genes which may be involved in fatty acid biosynthesis including elongation of very long chain fatty acids protein 5 (ELOVL5), fatty acid synthase (FASN), caspase 2 (CASP2) and thyroglobulin (TG)...
  24. Vahmani P, Meadus W, Rolland D, Duff P, Dugan M. Trans10,cis15 18:2 Isolated from Beef Fat Does Not Have the Same Anti-Adipogenic Properties as Trans10,cis12-18:2 in 3T3-L1 Adipocytes. Lipids. 2016;51:1231-1239 pubmed
    ..of genes related to fatty acid synthesis (ACACA, FASN), delta-9 desaturation (SCD1), fatty acid elongation (ELOVL5), and fatty acid uptake (LPL) and upregulated (P < 0...
  25. Kabeya N, Yamamoto Y, Cummins S, Elizur A, Yazawa R, Takeuchi Y, et al. Polyunsaturated fatty acid metabolism in a marine teleost, Nibe croaker Nibea mitsukurii: Functional characterization of Fads2 desaturase and Elovl5 and Elovl4 elongases. Comp Biochem Physiol B Biochem Mol Biol. 2015;188:37-45 pubmed publisher
    ..The present study aimed to investigate the biochemical functions of the Elovl5, Elovl4 and Fads2 enzymes involved in the DHA biosynthetic pathway in the Nibe croaker...
  26. Kjellqvist S, Klose C, Surma M, Hindy G, Mollet I, Johansson A, et al. Identification of Shared and Unique Serum Lipid Profiles in Diabetes Mellitus and Myocardial Infarction. J Am Heart Assoc. 2016;5: pubmed
    ..Fatty acid desaturases (FADS) and elongation of very long chain fatty acid protein 5 (ELOVL5) activities were estimated by calculating product to precursor ratios of polyunsaturated fatty acids in complex ..
  27. Carmona Antoñanzas G, Zheng X, Tocher D, Leaver M. Regulatory divergence of homeologous Atlantic salmon elovl5 genes following the salmonid-specific whole-genome duplication. Gene. 2016;591:34-42 pubmed publisher
    Fatty acyl elongase 5 (elovl5) is a critical enzyme in the vertebrate biosynthetic pathway which produces the physiologically essential long-chain polyunsaturated fatty acids (LC-PUFA), docosahexenoic acid (DHA), and eicosapentenoic acid (..
  28. Lin Z, Huang Y, Zou W, Rong H, Hao M, Wen X. Cloning, tissue distribution, functional characterization and nutritional regulation of a fatty acyl Elovl5 elongase in chu's croaker Nibea coibor. Gene. 2018;659:11-21 pubmed publisher
    ..report on the molecular cloning, tissue distribution, functional characterization and nutritional regulation of a elovl5 gene from Nibea coibor...
  29. Jin M, Monroig O, Navarro J, Tocher D, Zhou Q. Molecular and functional characterisation of two elovl4 elongases involved in the biosynthesis of very long-chain (>C24) polyunsaturated fatty acids in black seabream Acanthopagrus schlegelii. Comp Biochem Physiol B Biochem Mol Biol. 2017;212:41-50 pubmed publisher
    ..schlegelii Elovl4-like elongases, Elovl4a and Elovl4b, characterised in the present study, along with those of the Elovl5 and fatty acyl desaturase (Fads2) proteins of A...
  30. Sudano M, Rascado T, Tata A, Belaz K, Santos V, Valente R, et al. Lipidome signatures in early bovine embryo development. Theriogenology. 2016;86:472-484.e1 pubmed publisher
    ..early bovine embryonic development and associate with the mRNA abundance of lipid metabolism-related genes (ACSL3, ELOVL5, and ELOVL6) and with the amount of cytoplasmic lipid droplets...
  31. Tripathy S, Lytle K, Stevens R, Bain J, Newgard C, Greenberg A, et al. Fatty acid elongase-5 (Elovl5) regulates hepatic triglyceride catabolism in obese C57BL/6J mice. J Lipid Res. 2014;55:1448-64 pubmed publisher
    ..induces obesity and fatty liver in C57BL/6J mice and suppresses expression of the PPAR-target gene, FA elongase 5 (Elovl5). Elovl5 plays a key role in MUFA and PUFA synthesis...
  32. Gonzalez Bengtsson A, Asadi A, Gao H, Dahlman Wright K, Jacobsson A. Estrogen Enhances the Expression of the Polyunsaturated Fatty Acid Elongase Elovl2 via ER? in Breast Cancer Cells. PLoS ONE. 2016;11:e0164241 pubmed publisher
    ..We demonstrate a robust up-regulation in the expression of the fatty acid elongases Elovl2 and Elovl5 upon estradiol stimulation in MCF7 cells, which was sustained for more than 24 hours...
  33. Ren H, Yu J, Xu P, Tang Y. Single nucleotide polymorphisms of Δ6-desaturase and Elovl5 segments and their associations with common carp (Cyprinus carpio) growth traits. Genet Mol Res. 2015;14:12848-54 pubmed publisher
    ..The Δ6-desaturase and Elovl5 elongase genes produce essential enzymes in the biosynthetic pathway of HUFAs...
  34. Borroni B, Di Gregorio E, Orsi L, Vaula G, Costanzi C, Tempia F, et al. Clinical and neuroradiological features of spinocerebellar ataxia 38 (SCA38). Parkinsonism Relat Disord. 2016;28:80-6 pubmed publisher
    SCA38 (MIM 611805) caused by mutations within the ELOVL5 gene, which encodes an enzyme involved in the synthesis of long-chain fatty acids with a high and specific expression in Purkinje cells, has recently been identified...
  35. Wang S, Chen J, Jiang D, Zhang Q, You C, Tocher D, et al. Hnf4? is involved in the regulation of vertebrate LC-PUFA biosynthesis: insights into the regulatory role of Hnf4? on expression of liver fatty acyl desaturases in the marine teleost Siganus canaliculatus. Fish Physiol Biochem. 2018;44:805-815 pubmed publisher
    ..is able to synthesize LC-PUFA as it has all the key enzyme activities required including ?6?5 Fads2, ?4 Fads2, Elovl5, and Elovl4...
  36. Jaya Ram A, Shu Chien A, Kuah M. Echium oil increased the expression of a Δ4 Fads2 fatty acyl desaturase and the deposition of n-3 long-chain polyunsaturated fatty acid in comparison with linseed oil in striped snakehead (Channa striata) muscle. Fish Physiol Biochem. 2016;42:1107-22 pubmed publisher
    ..whether the presence of a desaturase (Fads2) capable of ∆4 desaturation activities and an elongase (Elovl5) will leverage the provision of dietary SDA to produce a higher rate of LC-PUFA bioconversion...
  37. Geay F, Wenon D, Mellery J, Tinti E, Mandiki S, Tocher D, et al. Dietary Linseed Oil Reduces Growth While Differentially Impacting LC-PUFA Synthesis and Accretion into Tissues in Eurasian Perch (Perca fluviatilis). Lipids. 2015;50:1219-32 pubmed publisher
    ..However, fads2 and elovl5 gene expression and FADS2 enzyme activity were comparable between the two groups...
  38. Coutelier M, Coarelli G, Monin M, Konop J, Davoine C, Tesson C, et al. A panel study on patients with dominant cerebellar ataxia highlights the frequency of channelopathies. Brain. 2017;140:1579-1594 pubmed publisher
    ..Variants in AFG3L2 (n = 7) came next in frequency, and variants were rarely found in STBN2 (n = 2), ELOVL5, FGF14, STUB1 and TTBK2 (n = 1 each). Interestingly, possible risk factor variants were detected in SPG7 and POLG...
  39. Lauritzen L, Sørensen L, Harsløf L, Ritz C, Stark K, Astrup A, et al. Mendelian randomization shows sex-specific associations between long-chain PUFA-related genotypes and cognitive performance in Danish schoolchildren. Am J Clin Nutr. 2017;106:88-95 pubmed publisher
    ..b>Design: Associations between selected FADS1/2 SNPs (rs1535, rs174448, and rs174468) and ELOVL5 rs2397142, whole-blood fatty acid composition, and performance in the d2 Test of Attention and a reading test ..
  40. Zhang W, Zhang J, Cui L, Ma J, Chen C, Ai H, et al. Genetic architecture of fatty acid composition in the longissimus dorsi muscle revealed by genome-wide association studies on diverse pig populations. Genet Sel Evol. 2016;48:5 pubmed publisher
    ..The genes ELOVL5, ELOVL6, ELOVL7, FASN, SCD and THRSP, which have functions that are directly relevant to fatty acid metabolism, ..
  41. Zhang M, Li C, Li F, Li H, Liu X, Loor J, et al. Estrogen Promotes Hepatic Synthesis of Long-Chain Polyunsaturated Fatty Acids by Regulating ELOVL5 at Post-Transcriptional Level in Laying Hens. Int J Mol Sci. 2017;18: pubmed publisher
    ..In this study, we detected that ELOVL5, which plays a key role in the biosynthesis of omega-3 (n-3) and omega-6 (n-6) polyunsaturated ..
  42. Lorenz S, Barøy T, Sun J, Nome T, Vodák D, Bryne J, et al. Unscrambling the genomic chaos of osteosarcoma reveals extensive transcript fusion, recurrent rearrangements and frequent novel TP53 aberrations. Oncotarget. 2016;7:5273-88 pubmed publisher
    ..certain recurrent rearrangements were identified and further validated in patient biopsies, including a PMP22-ELOVL5 gene fusion, genomic structural variations affecting RB1, MTAP/CDKN2A and MDM2, and, most frequently, ..
  43. Dai W, Panserat S, Kaushik S, Terrier F, Plagnes Juan E, Seiliez I, et al. Hepatic fatty acid biosynthesis is more responsive to protein than carbohydrate in rainbow trout during acute stimulations. Am J Physiol Regul Integr Comp Physiol. 2016;310:R74-86 pubmed publisher
    ..FAS) and ATP citrate lyase (ACLY)], lipid bioconversion [elongation of very long chain fatty acids like-5 (Elovl5), Elovl2, Δ6 fatty acyl desaturase (D6D) and stearoyl-CoA desaturase-1 (SCD1)], NADPH production [glucose-6-..
  44. Rocha Rodrigues S, Rodríguez A, Gonçalves I, Moreira A, Maciel E, Santos S, et al. Impact of physical exercise on visceral adipose tissue fatty acid profile and inflammation in response to a high-fat diet regimen. Int J Biochem Cell Biol. 2017;87:114-124 pubmed publisher
    ..ET increased eWAT fatty acid desaturase 1 (FADS1) and elongase 5 (ELOVL5) protein content in both diet types...
  45. Monroig Ã, Lopes Marques M, Navarro J, Hontoria F, Ruivo R, Santos M, et al. Evolutionary functional elaboration of the Elovl2/5 gene family in chordates. Sci Rep. 2016;6:20510 pubmed publisher
    ..Here we examine key components of the LC-PUFA cascade, the Elovl2/Elovl5 elongases, from amphioxus, an invertebrate chordate, the sea lamprey, a representative of agnathans, and the ..
  46. Li W, Feng Z, Song X, Zhu W, Hu Y. Cloning, expression and functional characterization of the polyunsaturated fatty acid elongase (ELOVL5) gene from sea cucumber (Apostichopus japonicus). Gene. 2016;593:217-224 pubmed publisher
    ..To study the function of elongase genes in the PUFA biosynthesis of Apostichopus japonicus, we cloned an ELOVL5 homology gene from intestinal cDNA of A. japonicus (Aj-ELOVL5)...
  47. Lemos M, Chiaia H, Berton M, Feitosa F, Aboujaoud C, Camargo G, et al. Genome-wide association between single nucleotide polymorphisms with beef fatty acid profile in Nellore cattle using the single step procedure. BMC Genomics. 2016;17:213 pubmed publisher
    ..The identification of such regions and the respective candidate genes, such as ELOVL5, ESSRG, PCYT1A and genes of the ABC group (ABC5, ABC6 and ABC10), should contribute to form a genetic basis of the ..
  48. Zhou X, Wan D, Zhang Y, Zhang Y, Long C, Chen S, et al. Diurnal variations in polyunsaturated fatty acid contents and expression of genes involved in their de novo synthesis in pigs. Biochem Biophys Res Commun. 2017;483:430-434 pubmed publisher
    ..variations were also observed in mRNA expression of FASD1 (Delta 5-desaturase), FASD2 (Delta 6-desaturase), ELOVL5 (fatty acid elongase 5) and ELOVL2 in liver, with an unexpectedly high level at night...
  49. Xie D, Chen F, Lin S, You C, Wang S, Zhang Q, et al. Long-chain polyunsaturated fatty acid biosynthesis in the euryhaline herbivorous teleost Scatophagus argus: Functional characterization, tissue expression and nutritional regulation of two fatty acyl elongases. Comp Biochem Physiol B Biochem Mol Biol. 2016;198:37-45 pubmed publisher
    ..One has 885bp of open read fragment (ORF) encoding a protein with 294 amino acid (aa) showing Elovl5 activity functionally characterized by heterologous expression in yeast, which was primarily active for the ..
  50. Kemiläinen H, Huhtinen K, Auranen A, Carpén O, Strauss L, Poutanen M. The Expression of HSD17B12 Is Associated with COX-2 Expression and Is Increased in High-Grade Epithelial Ovarian Cancer. Oncology. 2018;94:233-242 pubmed publisher
    ..study its coexpression with its upstream and downstream enzymes in the AA pathway, namely elongation of very long chain fatty acids protein 5 (ELOVL5) and cyclooxygenase-2 (COX-2), respectively...
  51. Aimola I, Inuwa H, Nok A, Mamman A, Bieker J. Cis-vaccenic acid induces differentiation and up-regulates gamma globin synthesis in K562, JK1 and transgenic mice erythroid progenitor stem cells. Eur J Pharmacol. 2016;776:9-18 pubmed publisher
    ..Inhibition of JK-1 and Transgenic mice bone marrow erythroid progenitor stem cells Fatty acid elongase 5 (Elovl5) and Δ(9) desaturase suppressed the γ-globin inductive effects of CVA...
  52. You C, Jiang D, Zhang Q, Xie D, Wang S, Dong Y, et al. Cloning and expression characterization of peroxisome proliferator-activated receptors (PPARs) with their agonists, dietary lipids, and ambient salinity in rabbitfish Siganus canaliculatus. Comp Biochem Physiol B Biochem Mol Biol. 2017;206:54-64 pubmed publisher
    ..the PPAR agonists 2-bromopalmitate (2-Bro) and fenofibrate (FF) increased the expression of PPAR?, SREBP1c and Elovl5, whereas FF depressed the expression of ?6/?5 Fad...
  53. Silva Brito F, Magnoni L, Fonseca S, Peixoto M, Castro L, Cunha I, et al. Dietary Oil Source and Selenium Supplementation Modulate Fads2 and Elovl5 Transcriptional Levels in Liver and Brain of Meagre (Argyrosomus regius). Lipids. 2016;51:729-41 pubmed publisher
    ..We analyzed changes in fatty acid (FA) desaturase 2 (fads2) and FA elongase 5 (elovl5) mRNA levels in livers and brains in response to FO replacement with a blend of vegetable oils (VO) and selenium (..
  54. Warzych E, Pawlak P, Pszczola M, Cieslak A, Madeja Z, Lechniak D. Interactions of bovine oocytes with follicular elements with respect to lipid metabolism. Anim Sci J. 2017;88:1491-1497 pubmed publisher
    ..in oocytes (BODIPY staining), mRNA expression of seven genes in cumulus and granulosa cells (SCD, FADS2, ELOVL2, ELOVL5, GLUT1, GLUT3, GLUT8; real time polymerase chain reaction) and fatty acid (FA) composition in FF (gas ..
  55. Warzych E, Pawlak P, Pszczola M, Cieslak A, Lechniak D. Prepubertal heifers versus cows-The differences in the follicular environment. Theriogenology. 2017;87:36-47 pubmed publisher
    ..number in oocytes, expression of seven genes involved in energy metabolism (fatty acids [FAs] metabolism-ELOVL2, ELOVL5, SCD, FADS2, glucose transport-GLUT1, GLUT3, GLUT8) in CC and GC as well as FA composition and glucose ..
  56. Zhang J, Qin X, Liang A, Kim E, Lawrence P, Park W, et al. Fads3 modulates docosahexaenoic acid in liver and brain. Prostaglandins Leukot Essent Fatty Acids. 2017;123:25-32 pubmed publisher
    ..levels were significantly downregulated whereas expression levels of elongation of very long chain 2 (Elovl2) and Elovl5 genes were upregulated compared to age-matched WT...
  57. Yamashita Y, Nishiumi S, Kono S, Takao S, Azuma T, Yoshida M. Differences in elongation of very long chain fatty acids and fatty acid metabolism between triple-negative and hormone receptor-positive breast cancer. BMC Cancer. 2017;17:589 pubmed publisher
    ..TN and EP+H- tumors demonstrated stronger ELOVL1 and 6 staining than the corresponding normal breast tissues, but ELOVL5 was not stained strongly in the TN or EP+H- tumors...
  58. Kabeya N, Chiba M, Haga Y, Satoh S, Yoshizaki G. Cloning and functional characterization of fads2 desaturase and elovl5 elongase from Japanese flounder Paralichthys olivaceus. Comp Biochem Physiol B Biochem Mol Biol. 2017;214:36-46 pubmed publisher
    ..Japanese flounder fatty acid desaturase 2 (Fads2) and elongation of very long-chain fatty acids protein 5 (Elovl5) in order to precisely characterize the LC-PUFA biosynthesis pathway...
  59. Tripathy S, Jump D. Elovl5 regulates the mTORC2-Akt-FOXO1 pathway by controlling hepatic cis-vaccenic acid synthesis in diet-induced obese mice. J Lipid Res. 2013;54:71-84 pubmed publisher
    Elevated hepatic expression of fatty acid elongase-5 (Elovl5) induces FoxO1 phosphorylation, lowers FoxO1 nuclear content, and suppresses expression of genes involved in gluconeogenesis (GNG)...
  60. Soh J, Iqbal J, Queiroz J, Fernandez Hernando C, Hussain M. MicroRNA-30c reduces hyperlipidemia and atherosclerosis in mice by decreasing lipid synthesis and lipoprotein secretion. Nat Med. 2013;19:892-900 pubmed publisher
    ..Raising miR-30c levels might be useful in treating hyperlipidemias and associated disorders. ..
  61. Li M, Zhai S, Xie Q, Tian L, Li X, Zhang J, et al. Effects of Dietary n-6:n-3 PUFA Ratios on Lipid Levels and Fatty Acid Profile of Cherry Valley Ducks at 15-42 Days of Age. J Agric Food Chem. 2017;65:9995-10002 pubmed publisher
    ..The hepatic expression of FADS2, ELOVL5, FADS1, and ELOVL2 increased on a quadratic function with decreasing dietary n-6:n-3 PUFA ratios...
  62. Kalogeropoulos A, Psaty B, Vasan R, Georgiopoulou V, Smith A, Smith N, et al. Validation of the health ABC heart failure model for incident heart failure risk prediction: the Cardiovascular Health Study. Circ Heart Fail. 2010;3:495-502 pubmed publisher
    ..This tool may be used to identify individuals to whom to target heart failure prevention efforts. ..
  63. Nayak M, Pradhan A, Giri S, Samanta M, Konkimalla V, Saha A. Molecular characterization, tissue distribution and differential nutritional regulation of putative Elovl5 elongase in silver barb (Puntius gonionotus). Comp Biochem Physiol B Biochem Mol Biol. 2018;217:27-39 pubmed publisher
    ..In the present study elovl5-like elongase full-length cDNA was cloned and characterized by RACE (rapid amplification of cDNA ends), and ..
  64. Meguro A, Inoko H, Ota M, Mizuki N, Bahram S. Genome-wide association study of normal tension glaucoma: common variants in SRBD1 and ELOVL5 contribute to disease susceptibility. Ophthalmology. 2010;117:1331-8.e5 pubmed publisher
    ..NTG-associated SNPs, rs3213787 and rs735860, are located in an intron of SRBD1 and the 3'-untranslated region of ELOVL5 (P = 2.5 x 10(-9), odds ratio = 2.80 and P = 4.1 x 10(-6), odds ratio = 1.69), respectively...
  65. Boot A, Oosting J, van Eendenburg J, Kuppen P, Morreau H, van Wezel T. Methylation associated transcriptional repression of ELOVL5 in novel colorectal cancer cell lines. PLoS ONE. 2017;12:e0184900 pubmed publisher
    ..Our analysis identified ELOVL5, FAM127B, MTERF1, ZNF606 to be subject to transcriptional downregulation through DNA hypermethylation in CRC...
  66. Jack Roberts C, Joselit Y, Nanobashvili K, Bretter R, Malysheva O, Caudill M, et al. Choline Supplementation Normalizes Fetal Adiposity and Reduces Lipogenic Gene Expression in a Mouse Model of Maternal Obesity. Nutrients. 2017;9: pubmed publisher
    ..mRNA levels of lipogenic genes such as Acc1, Fads1, and Elovl5, as well as the transcription factor Srebp1c that favors lipogenesis were downregulated (p < ..
  67. Liu Z, Zeng S, Zeng J, Zhou Y, Zeng X, Jiang H, et al. SCA38 is rare in Mainland China. J Neurol Sci. 2015;358:333-4 pubmed publisher
    ..Recently, mutations in the elongation of a very long chain fatty acids-5 gene (ELOVL5) were reported to cause a SCA38 subtype...
  68. Di Gregorio E, Borroni B, Giorgio E, Lacerenza D, Ferrero M, Lo Buono N, et al. ELOVL5 mutations cause spinocerebellar ataxia 38. Am J Hum Genet. 2014;95:209-17 pubmed publisher
    ..Targeted resequencing identified a single missense mutation (c.689G>T [p.Gly230Val]) in ELOVL5. Mutation screening of 456 independent SCA-affected individuals identified the same mutation in two further ..
  69. Leonard A, Bobik E, Dorado J, Kroeger P, Chuang L, Thurmond J, et al. Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids. Biochem J. 2000;350 Pt 3:765-70 pubmed
    ..The resulting full-length sequence, termed HELO1, consisted of 897 bp, which encoded 299 amino acids...
  70. Leonard A, Pereira S, Sprecher H, Huang Y. Elongation of long-chain fatty acids. Prog Lipid Res. 2004;43:36-54 pubmed
  71. Roy S, Chakraborty H, Kumar V, Behera B, Rana R, Babu G. In Silico Structural Studies and Molecular Docking Analysis of Delta6-desaturase in HUFA Biosynthetic Pathway. Anim Biotechnol. 2017;:1-13 pubmed publisher
    ..Protein association analysis showed a high confidence score with acyl-CoA synthetase, elovl5, elovl2, and phospholipase A2...
  72. Aslibekyan S, Jensen M, Campos H, Linkletter C, Loucks E, Ordovas J, et al. Genetic variation in fatty acid elongases is not associated with intermediate cardiovascular phenotypes or myocardial infarction. Eur J Clin Nutr. 2012;66:353-9 pubmed publisher
    Elongases 2, 4 and 5, encoded by genes ELOVL2, ELOVL4 and ELOVL5, have a key role in the biosynthesis of very long chain polyunsaturated fatty acids (PUFAs)...
  73. Shikama A, Shinozaki H, Takeuchi Y, Matsuzaka T, Aita Y, Murayama T, et al. Identification of human ELOVL5 enhancer regions controlled by SREBP. Biochem Biophys Res Commun. 2015;465:857-63 pubmed publisher
    Fatty acid elongase 5 (ELOVL5) is an enzyme involved in the synthesis of polyunsaturated fatty acids...
  74. Mabuchi F, Sakurada Y, Kashiwagi K, Yamagata Z, Iijima H, Tsukahara S. Association between SRBD1 and ELOVL5 gene polymorphisms and primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2011;52:4626-9 pubmed publisher
    The S1 RNA binding domain 1 (SRBD1) and elongation of long-chain fatty acids family member 5 (ELOVL5) have been reported to be susceptibility genes for early-onset normal-tension glaucoma (NTG)...
  75. Chisaguano A, Montes R, Pérez Berezo T, Castellote A, Guerendiain M, Bustamante M, et al. Gene expression of desaturase (FADS1 and FADS2) and Elongase (ELOVL5) enzymes in peripheral blood: association with polyunsaturated fatty acid levels and atopic eczema in 4-year-old children. PLoS ONE. 2013;8:e78245 pubmed publisher
    ..We analyzed whether mRNA-expression of genes encoding key enzymes of LC-PUFA synthesis (FADS1, FADS2 and ELOVL5) is associated with circulating LC-PUFA levels and risk of AE in 4-year-old children...
  76. Li X, Gan Z, Ding Z, Wu Y, Chen X, Tian H, et al. Genetic Variants in the ELOVL5 but not ELOVL2 Gene Associated with Polyunsaturated Fatty Acids in Han Chinese Breast Milk. Biomed Environ Sci. 2017;30:64-67 pubmed publisher
    ..Carriers of minor alleles of SNPs (rs2397142 and rs9357760) in ELOVL5 were associated with higher levels of linoleic acid (LA), dihomo-?-linolenic acid (DGLA), arachidonic acid (AA), ..
  77. Fadhlaoui M, Pierron F, Couture P. Temperature and metal exposure affect membrane fatty acid composition and transcription of desaturases and elongases in fathead minnow muscle and brain. Ecotoxicol Environ Saf. 2018;148:632-643 pubmed publisher
    ..this end, muscle and brain membrane FA composition and FA desaturase (fads2, degs2 and scd2) and elongase (elovl2, elovl5 and elovl6) gene transcription levels were analyzed in fathead minnows (Pimephales promelas) acclimated for eight ..
  78. Bouaziz M, Bejaoui S, Rabeh I, Besbes R, El Cafsi M, Falcon J. Impact of temperature on sea bass, Dicentrarchus labrax, retina: Fatty acid composition, expression of rhodopsin and enzymes of lipid and melatonin metabolism. Exp Eye Res. 2017;159:87-97 pubmed publisher
    ..and mRNA abundance of key enzymes of lipid metabolism: fatty acid desaturase-2 (FADS2), fatty acid elongase-5 (ELOVL5), sterol regulatory element-binding protein-1 (SREBP-1), triglyceride lipase and phospholipase A2 (PLA2)...
  79. Manes M, Alberici A, Di Gregorio E, Boccone L, Premi E, Mitro N, et al. Docosahexaenoic acid is a beneficial replacement treatment for spinocerebellar ataxia 38. Ann Neurol. 2017;82:615-621 pubmed publisher
    b>Spinocerebellar ataxia 38 (SCA38) is caused by mutations in the ELOVL5 gene, which encodes an elongase involved in the synthesis of polyunsaturated fatty acids, including docosahexaenoic acid (DHA)...
  80. Ohno Y, Suto S, Yamanaka M, Mizutani Y, Mitsutake S, Igarashi Y, et al. ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis. Proc Natl Acad Sci U S A. 2010;107:18439-44 pubmed publisher
    ..Finally, knockdown of ELOVL1 caused a reduction in the activity of the Src kinase LYN, confirming that C24-sphingolipids are particularly important in membrane microdomain function. ..
  81. Hoxha E, Gabriele R, Balbo I, Ravera F, Masante L, Zambelli V, et al. Motor Deficits and Cerebellar Atrophy in Elovl5 Knock Out Mice. Front Cell Neurosci. 2017;11:343 pubmed publisher
    ..type 38 (SCA38) is caused by missense mutations in the very long chain fatty acid elongase 5 gene, ELOVL5. The main clinical findings in this disease are ataxia, hyposmia and cerebellar atrophy...