ELOVL3

Summary

Gene Symbol: ELOVL3
Description: ELOVL fatty acid elongase 3
Alias: CIG-30, CIG30, elongation of very long chain fatty acids protein 3, 3-keto acyl-CoA synthase ELOVL3, ELOVL FA elongase 3, cold-inducible glycoprotein of 30 kDa, elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3, very long chain 3-ketoacyl-CoA synthase 3, very long chain 3-oxoacyl-CoA synthase 3
Species: human
Products:     ELOVL3

Top Publications

  1. Song X, Li B, Wang H, Zou X, Gao R, Zhang W, et al. Asthma alleviates obesity in males through regulating metabolism and energy expenditure. Biochim Biophys Acta Mol Basis Dis. 2018;: pubmed publisher
    ..of AMPK/Sirt1/PGC1α signaling promoted the expression of the thermogenic genes like ucp1, PRDM16, cidea, Elovl3, PPARα, which occurred in brown adipocyte tissue and subcutaneous white adipose tissue...
  2. Guttman Yassky E, Bissonnette R, Ungar B, Suárez Fariñas M, Ardeleanu M, Esaki H, et al. Dupilumab progressively improves systemic and cutaneous abnormalities in atopic dermatitis patients. J Allergy Clin Immunol. 2018;: pubmed publisher
    ..increased expression of epidermal differentiation, barrier, and lipid-metabolism genes (FLG/LOR/claudins/ELOVL3). Dupilumab reduced lesional epidermal thickness versus placebo (week 4, P=0.001; week 16, P=0.0002)...
  3. Takeda Y, Kang H, Lih F, Jiang H, Blaner W, Jetten A. Retinoid acid-related orphan receptor γ, RORγ, participates in diurnal transcriptional regulation of lipid metabolic genes. Nucleic Acids Res. 2014;42:10448-59 pubmed publisher
    ..metabolic genes, including the insulin-induced gene 2a, Insig2a, elongation of very long chain fatty acids-like 3, Elovl3 and sterol 12α-hydroxylase, Cyp8b1, by enhancing their expression at ZT20-4...
  4. Tomilov A, Bettaieb A, Kim K, Sahdeo S, Tomilova N, Lam A, et al. Shc depletion stimulates brown fat activity in vivo and in vitro. Aging Cell. 2014;13:1049-58 pubmed publisher
    ..Levels of brown fat-specific markers of differentiation, UCP1, PRDM16, ELOVL3, and Cox8b, were higher in ShcKO BAT...
  5. Maher R, Barbash S, Lynch D, Swoap S. Group housing and nest building only slightly ameliorate the cold stress of typical housing in female C57BL/6J mice. Am J Physiol Regul Integr Comp Physiol. 2015;308:R1070-9 pubmed publisher
    ..as assessed by heart rate (HR), blood pressure (BP), triiodothyronine (T3), brown adipose (BAT) expression of Elovl3 mRNA, and BAT lipid content...
  6. Timmermans S, Van Hauwermeiren F, Puimège L, Dejager L, Van Wonterghem E, Vanhooren V, et al. Determining differentially expressed miRNAs and validating miRNA--target relationships using the SPRET/Ei mouse strain. Mamm Genome. 2015;26:94-107 pubmed publisher
    ..This resulted in the confirmation of six previously unknown miR-target interactions: miR-146a, Zdhhc2; miR-150, Elovl3, Kcnk5, and Nrd1d2; miR-155, Camta1; and miR-592, Steap2...
  7. Kuipers E, Dam A, Held N, Mol I, Houtkooper R, Rensen P, et al. Quercetin Lowers Plasma Triglycerides Accompanied by White Adipose Tissue Browning in Diet-Induced Obese Mice. Int J Mol Sci. 2018;19: pubmed publisher
    ..Furthermore, quercetin also markedly increased mRNA expression of Ucp1 (+229%, p < 0.05) and Elovl3 (+138%, p < 0.05), specifically in sWAT...
  8. Araki M, Nakagawa Y, Oishi A, Han S, Wang Y, Kumagai K, et al. The Peroxisome Proliferator-Activated Receptor α (PPARα) Agonist Pemafibrate Protects against Diet-Induced Obesity in Mice. Int J Mol Sci. 2018;19: pubmed publisher
    ..i>Ucp1, Cidea and Cpt1b in inguinal adipose tissue (iWAT) and the mitochondrial marker Elovl3 in brown adipose tissue (BAT)...
  9. Malik K, He H, Huynh T, Tran G, Mueller K, Doytcheva K, et al. Ichthyosis molecular fingerprinting shows profound Th17-skewing and a unique barrier genomic signature. J Allergy Clin Immunol. 2018;: pubmed publisher
    ..junction alterations of AD (LOR, FLG, CLDN 1), but showed characteristic alterations in lipid metabolism genes (ELOVL3, GAL), with parallel reductions in extracellular lipids and corneocyte compaction in all ichthyoses except EI, ..

More Information

Publications28

  1. Brunner P, Israel A, Zhang N, Leonard A, Wen H, Huynh T, et al. Early-onset pediatric atopic dermatitis is characterized by TH2/TH17/TH22-centered inflammation and lipid alterations. J Allergy Clin Immunol. 2018;141:2094-2106 pubmed publisher
    ..Defects in the lipid barrier (eg, ELOVL fatty acid elongase 3 [ELOVL3] and diacylglycerol o-acyltransferase 2 [DGAT2]) and tight junction regulation (eg, claudins 8 and 23) were ..
  2. Piao Z, Zhai B, Jiang X, Dong M, Yan C, Lin J, et al. Reduced adiposity by compensatory WAT browning upon iBAT removal in mice. Biochem Biophys Res Commun. 2018;501:807-813 pubmed publisher
    ..dynamic morphological changes in BAT were confirmed by gene expression changes in ADRB3 and PGC1?, while UCP1 and ELOVL3 expression was continuously up-regulated throughout the entire cold exposure period...
  3. Xu J, Liu D, Yin H, Tong H, Li S, Yan Y. Fatty acids promote bovine skeletal muscle satellite cell differentiation by regulating ELOVL3 expression. Cell Tissue Res. 2018;373:499-508 pubmed publisher
    ..Additionally, FA-induced bovine MDSC differentiation increased ELOVL3 expression and relocation of ELOVL3 to cytoplasmic lipid droplets in the differentiation of bovine MDSCs...
  4. Defour M, Dijk W, Ruppert P, Nascimento E, Schrauwen P, Kersten S. The Peroxisome Proliferator-Activated Receptor ? is dispensable for cold-induced adipose tissue browning in mice. Mol Metab. 2018;10:39-54 pubmed publisher
    ..Furthermore, cold-mediated induction of genes related to thermogenesis such as Ucp1, Elovl3, Cox7a1, Cox8, and Cidea, as well as many PPAR target genes, was similar in wildtype and PPAR?-/- mice...
  5. Ji L, Gupta M, Feldman B. Vitamin D Regulates Fatty Acid Composition in Subcutaneous Adipose Tissue Through Elovl3. Endocrinology. 2016;157:91-7 pubmed publisher
    ..We revealed that a specific elongase enzyme (Elovl3), which has an important role in brown fat biology, is directly regulated by VDR and likely contributes to the ..
  6. Ewald D, Malajian D, Krueger J, Workman C, Wang T, Tian S, et al. Meta-analysis derived atopic dermatitis (MADAD) transcriptome defines a robust AD signature highlighting the involvement of atherosclerosis and lipid metabolism pathways. BMC Med Genomics. 2015;8:60 pubmed publisher
    ..the first time in vivo, correlated Th2 immune activation with downregulation of key epidermal lipids (FA2H, FAR2, ELOVL3), emphasizing the role of cytokines on the barrier disruption in AD...
  7. Weitkunat K, Schumann S, Petzke K, Blaut M, Loh G, Klaus S. Effects of dietary inulin on bacterial growth, short-chain fatty acid production and hepatic lipid metabolism in gnotobiotic mice. J Nutr Biochem. 2015;26:929-37 pubmed publisher
    ..Hepatic expression of genes involved in lipogenesis (Fasn, Gpam) and fatty acid elongation/desaturation (Scd1, Elovl3, Elovl6, Elovl5, Fads1 and Fads2) were decreased in inulin-fed animals...
  8. Kretz M, Siprashvili Z, Chu C, Webster D, Zehnder A, Qu K, et al. Control of somatic tissue differentiation by the long non-coding RNA TINCR. Nature. 2013;493:231-5 pubmed publisher
    ..genes, many of which are mutated in human skin diseases, including FLG, LOR, ALOXE3, ALOX12B, ABCA12, CASP14 and ELOVL3. TINCR-deficient epidermis lacked terminal differentiation ultrastructure, including keratohyalin granules and ..
  9. Ruiz Larrañaga O, Langa J, Rendo F, Manzano C, Iriondo M, Estonba A. Genomic selection signatures in sheep from the Western Pyrenees. Genet Sel Evol. 2018;50:9 pubmed publisher
    ..the strongest signals and harbored several candidate genes related to energy metabolism and morphology (BBS9, ELOVL3 and LDB1), immunity (NFKB2), and reproduction (H2AFZ)...
  10. Zhang F, Ai W, Hu X, Meng Y, Yuan C, Su H, et al. Phytol stimulates the browning of white adipocytes through the activation of AMP-activated protein kinase (AMPK) α in mice fed high-fat diet. Food Funct. 2018;9:2043-2050 pubmed publisher
    ..mRNA and/or protein expression of brown adipocyte markers (UCP1, PRDM16, PGC1α, PDH, Cyto C, Cidea and Elovl3) and beige adipocyte markers (CD137 and TMEM26)...
  11. Ohno Y, Suto S, Yamanaka M, Mizutani Y, Mitsutake S, Igarashi Y, et al. ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis. Proc Natl Acad Sci U S A. 2010;107:18439-44 pubmed publisher
    ..Finally, knockdown of ELOVL1 caused a reduction in the activity of the Src kinase LYN, confirming that C24-sphingolipids are particularly important in membrane microdomain function. ..
  12. Kobayashi T, Zadravec D, Jacobsson A. ELOVL2 overexpression enhances triacylglycerol synthesis in 3T3-L1 and F442A cells. FEBS Lett. 2007;581:3157-63 pubmed
    ..of very long-chain fatty acids (ELOVL) members were overexpressed in two preadipocyte cell lines, ELOVL2 and ELOVL3 in 3T3-L1 cells, and ELOVL1-3 in F442A cells...
  13. Monne M, Gafvelin G, Nilsson R, von Heijne G. N-tail translocation in a eukaryotic polytopic membrane protein: synergy between neighboring transmembrane segments. Eur J Biochem. 1999;263:264-9 pubmed
    We have used the natural N-glycosylation site in the N-tail of cig30, a eukaryotic polytopic membrane protein, as a marker for N-tail translocation across the microsomal membrane...
  14. Leonard A, Bobik E, Dorado J, Kroeger P, Chuang L, Thurmond J, et al. Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids. Biochem J. 2000;350 Pt 3:765-70 pubmed
    ..Furthermore, the HELO1 gene is located on chromosome 6, best known for encoding the major histocompatibility complex, which is essential to the human immune response. ..
  15. Fontao F, Barnes L, Kaya G, Saurat J, Sorg O. High susceptibility of Lrig1 sebaceous stem cells to TCDD in mice. Toxicol Sci. 2017;: pubmed publisher
    ..of CYP1A1 within the glands, and (iii) a dramatic repression of the genes encoding the sebogenic enzymes AWAT1, ELOVL3 and SCD1. These effects were reversible...
  16. Kristof E, Doan Xuan Q, Sárvári A, Klusóczki Á, Fischer Posovszky P, Wabitsch M, et al. Clozapine modifies the differentiation program of human adipocytes inducing browning. Transl Psychiatry. 2016;6:e963 pubmed publisher
    ..Furthermore, clozapine significantly upregulated ELOVL3, CIDEA, CYC1, PGC1A and TBX1 genes but not ZIC1 suggesting induction of the beige-like and not the classical brown ..
  17. Westerberg R, Tvrdik P, Unden A, Månsson J, Norlen L, Jakobsson A, et al. Role for ELOVL3 and fatty acid chain length in development of hair and skin function. J Biol Chem. 2004;279:5621-9 pubmed
    ..Here, we report that the Elovl3 gene product, which belongs to a highly conserved family of microsomal enzymes involved in the formation of very ..
  18. Liu D, Xu J, Tong H, Li S, Yan Y. Effect of ELOVL3 expression on bovine skeletal muscle-derived satellite cell differentiation. Biochem Biophys Res Commun. 2017;493:1457-1463 pubmed publisher
    b>ELOVL3 is involved in elongating saturated and monounsaturated fatty acids, and is a critical enzyme for lipid accumulation in brown adipocytes during the early phase of tissue recruitment...
  19. Loyd C, Liu Y, Kim T, Holleman C, Galloway J, Bethea M, et al. LDB1 Regulates Energy Homeostasis During Diet-Induced Obesity. Endocrinology. 2017;158:1289-1297 pubmed publisher
    ..energy expenditure during DIO was associated with significantly altered BAT gene expression, specifically Cidea, Elovl3, Cox7a1, and Dio2...