ELOVL3

Summary

Gene Symbol: ELOVL3
Description: ELOVL fatty acid elongase 3
Alias: CIG-30, CIG30, elongation of very long chain fatty acids protein 3, 3-keto acyl-CoA synthase ELOVL3, ELOVL FA elongase 3, cold-inducible glycoprotein of 30 kDa, elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3, very long chain 3-ketoacyl-CoA synthase 3, very long chain 3-oxoacyl-CoA synthase 3
Species: human

Top Publications

  1. pmc Shc depletion stimulates brown fat activity in vivo and in vitro
    Alexey Tomilov
    Department of Molecular Biosciences, UC Davis, Davis, CA, 95616, USA
    Aging Cell 13:1049-58. 2014
  2. pmc ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis
    Yusuke Ohno
    Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12 jo, Nishi 6 choume, Kita ku, Sapporo 060 0812, Japan
    Proc Natl Acad Sci U S A 107:18439-44. 2010
  3. doi The formation of brown adipose tissue induced by transgenic over-expression of PPARγ2
    Ying Zhou
    Key Laboratory of Swine Genetics and Breeding of the Ministry of Agriculture, College of Animal Sciences, Huazhong Agricultural University, Wuhan 430070, China
    Biochem Biophys Res Commun 446:959-64. 2014
  4. pmc Dose-dependent effect of estrogen suppresses the osteo-adipogenic transdifferentiation of osteoblasts via canonical Wnt signaling pathway
    Bo Gao
    Institute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical University, Xi an, People s Republic of China
    PLoS ONE 9:e99137. 2014
  5. pmc Ontogeny of hepatic energy metabolism genes in mice as revealed by RNA-sequencing
    Helen J Renaud
    Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, United States of America
    PLoS ONE 9:e104560. 2014
  6. pmc Retinoid acid-related orphan receptor γ, RORγ, participates in diurnal transcriptional regulation of lipid metabolic genes
    Yukimasa Takeda
    Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Nucleic Acids Res 42:10448-59. 2014
  7. doi Determining differentially expressed miRNAs and validating miRNA--target relationships using the SPRET/Ei mouse strain
    S Timmermans
    Inflammation Research Center IRC, VIB Ghent University, Technologiepark 927, Zwijnaarde, 9052, Ghent, Belgium
    Mamm Genome 26:94-107. 2015
  8. doi Group housing and nest building only slightly ameliorate the cold stress of typical housing in female C57BL/6J mice
    Rebecca L Maher
    Department of Biology, Williams College, Williamstown, Massachusetts
    Am J Physiol Regul Integr Comp Physiol 308:R1070-9. 2015
  9. doi Effects of dietary inulin on bacterial growth, short-chain fatty acid production and hepatic lipid metabolism in gnotobiotic mice
    Karolin Weitkunat
    German Institute of Human Nutrition in Potsdam Rehbruecke Group of Physiology of Energy Metabolism, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    J Nutr Biochem 26:929-37. 2015
  10. pmc Vitamin D Regulates Fatty Acid Composition in Subcutaneous Adipose Tissue Through Elovl3
    Lijuan Ji
    Department of Pediatrics, Division of Pediatric Endocrinology, Stanford University School of Medicine, Stanford, California 94305 5457
    Endocrinology 157:91-7. 2016

Scientific Experts

  • P Tvrdik
  • J E Gudjonsson
  • Tsutomu Kobayashi
  • Tsuyoshi Nagase
  • Anders Jacobsson
  • Damir Zadravec
  • Andreas Jakobsson
  • Herve Guillou
  • Rolf Westerberg
  • Annelie Brolinson
  • Lijuan Ji
  • E Kristof
  • Madhumita Patel
  • Christine Loyd
  • Rebecca L Maher
  • S Timmermans
  • Karolin Weitkunat
  • Johanna A Jorgensen
  • Bo Gao
  • Alexey Tomilov
  • Yukimasa Takeda
  • Helen J Renaud
  • Ying Zhou
  • Clara Gabás-Rivera
  • Hirokazu Matsumoto
  • Markus Kretz
  • Dagmar Fehrenschild
  • Hyejung Park
  • Yusuke Ohno
  • Tanya M Quist
  • Takashi Mizutani
  • Ana Anzulovich
  • Magnus Monné
  • Mario R Capecchi
  • Jan Erik Månsson
  • Hyo Jung Moon
  • Kirk M Habegger
  • Brian J Feldman
  • Chad Steele
  • Du Young Ko
  • Thomas A Swain
  • Glenn C Rowe
  • Mihir Gupta
  • Yanping Liu
  • Z Balajthy
  • Maigen Bethea
  • L Fesus
  • P Fischer-Posovszky
  • Á Klusóczki
  • Teayoun Kim
  • Jamie Galloway
  • Benjamin N Ediger
  • P Bai
  • Doris A Stoffers
  • Byeongmoon Jeong
  • A K Sárvári
  • Martin Young
  • Cassie Holleman
  • Chad S Hunter
  • Yawen Tang
  • Q M Doan-Xuan
  • M Wabitsch
  • Z Bacso
  • Sara Schumann
  • Steven J Swoap
  • L Puimege
  • F Van Hauwermeiren
  • V Vanhooren
  • L Dejager
  • R E Vandenbroucke
  • P Mestdagh
  • Michael Blaut
  • Klaus Jürgen Petzke
  • E Van Wonterghem
  • Shayna M Barbash
  • Gunnar Loh
  • Susanne Klaus
  • Daniel V Lynch
  • C Libert
  • Curtis D Klaassen
  • Yue Julia Cui
  • Jun Shi
  • Bo Zuo
  • Gino Cortopassi
  • Zhuqing Ren
  • Stephen Griffey
  • Douglas Rowland
  • Natalia Tomilova
  • Qiang Huang
  • Wangjun Wu

Detail Information

Publications39

  1. pmc Shc depletion stimulates brown fat activity in vivo and in vitro
    Alexey Tomilov
    Department of Molecular Biosciences, UC Davis, Davis, CA, 95616, USA
    Aging Cell 13:1049-58. 2014
    ..Levels of brown fat-specific markers of differentiation, UCP1, PRDM16, ELOVL3, and Cox8b, were higher in ShcKO BAT...
  2. pmc ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis
    Yusuke Ohno
    Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12 jo, Nishi 6 choume, Kita ku, Sapporo 060 0812, Japan
    Proc Natl Acad Sci U S A 107:18439-44. 2010
    ..Finally, knockdown of ELOVL1 caused a reduction in the activity of the Src kinase LYN, confirming that C24-sphingolipids are particularly important in membrane microdomain function...
  3. doi The formation of brown adipose tissue induced by transgenic over-expression of PPARγ2
    Ying Zhou
    Key Laboratory of Swine Genetics and Breeding of the Ministry of Agriculture, College of Animal Sciences, Huazhong Agricultural University, Wuhan 430070, China
    Biochem Biophys Res Commun 446:959-64. 2014
    ..The transgenic mice had remarkably elevated mRNA level of UCP1, Elovl3, PGC1α and Cebpα in subcutaneous fat...
  4. pmc Dose-dependent effect of estrogen suppresses the osteo-adipogenic transdifferentiation of osteoblasts via canonical Wnt signaling pathway
    Bo Gao
    Institute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical University, Xi an, People s Republic of China
    PLoS ONE 9:e99137. 2014
    ..05). Moreover, the expression levels of brown adipocyte markers (Myf5, Elovl3, and Cidea) and undifferentiated adipocyte markers (Dlk1, Gata2, and Wnt10b) were also affected by 17β-estradiol ..
  5. pmc Ontogeny of hepatic energy metabolism genes in mice as revealed by RNA-sequencing
    Helen J Renaud
    Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, United States of America
    PLoS ONE 9:e104560. 2014
    ..These data shed new light on the ontogeny of homeostatic regulation of hepatic energy metabolism, which could ultimately provide new therapeutic targets for metabolic diseases. ..
  6. pmc Retinoid acid-related orphan receptor γ, RORγ, participates in diurnal transcriptional regulation of lipid metabolic genes
    Yukimasa Takeda
    Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Nucleic Acids Res 42:10448-59. 2014
    ..metabolic genes, including the insulin-induced gene 2a, Insig2a, elongation of very long chain fatty acids-like 3, Elovl3 and sterol 12α-hydroxylase, Cyp8b1, by enhancing their expression at ZT20-4...
  7. doi Determining differentially expressed miRNAs and validating miRNA--target relationships using the SPRET/Ei mouse strain
    S Timmermans
    Inflammation Research Center IRC, VIB Ghent University, Technologiepark 927, Zwijnaarde, 9052, Ghent, Belgium
    Mamm Genome 26:94-107. 2015
    ..This resulted in the confirmation of six previously unknown miR-target interactions: miR-146a, Zdhhc2; miR-150, Elovl3, Kcnk5, and Nrd1d2; miR-155, Camta1; and miR-592, Steap2...
  8. doi Group housing and nest building only slightly ameliorate the cold stress of typical housing in female C57BL/6J mice
    Rebecca L Maher
    Department of Biology, Williams College, Williamstown, Massachusetts
    Am J Physiol Regul Integr Comp Physiol 308:R1070-9. 2015
    ..as assessed by heart rate (HR), blood pressure (BP), triiodothyronine (T3), brown adipose (BAT) expression of Elovl3 mRNA, and BAT lipid content...
  9. doi Effects of dietary inulin on bacterial growth, short-chain fatty acid production and hepatic lipid metabolism in gnotobiotic mice
    Karolin Weitkunat
    German Institute of Human Nutrition in Potsdam Rehbruecke Group of Physiology of Energy Metabolism, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    J Nutr Biochem 26:929-37. 2015
    ..Hepatic expression of genes involved in lipogenesis (Fasn, Gpam) and fatty acid elongation/desaturation (Scd1, Elovl3, Elovl6, Elovl5, Fads1 and Fads2) were decreased in inulin-fed animals...
  10. pmc Vitamin D Regulates Fatty Acid Composition in Subcutaneous Adipose Tissue Through Elovl3
    Lijuan Ji
    Department of Pediatrics, Division of Pediatric Endocrinology, Stanford University School of Medicine, Stanford, California 94305 5457
    Endocrinology 157:91-7. 2016
    ..We revealed that a specific elongase enzyme (Elovl3), which has an important role in brown fat biology, is directly regulated by VDR and likely contributes to the ..
  11. pmc Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids
    A E Leonard
    Department of Strategic Discovery Research, Ross Products Division, Abbott Laboratories, 3300 Stelzer Road, Columbus, OH 43219, USA
    Biochem J 350:765-70. 2000
    ..Furthermore, the HELO1 gene is located on chromosome 6, best known for encoding the major histocompatibility complex, which is essential to the human immune response...
  12. doi Composite System of Graphene Oxide and Polypeptide Thermogel As an Injectable 3D Scaffold for Adipogenic Differentiation of Tonsil-Derived Mesenchymal Stem Cells
    Madhumita Patel
    Department of Chemistry and Nanoscience, Ewha Womans University, 52 Ewhayeodae gil, Seodaemun gu, Seoul, Korea
    ACS Appl Mater Interfaces 8:5160-9. 2016
    ..solution significantly enhances the expression of adipogenic biomarkers, including PPAR-γ, CEBP-α, LPL, AP2, ELOVL3, and HSL, compared to both a pure hydrogel system and a composite system of G/P, graphene-incorporated hydrogel...
  13. pmc Clozapine modifies the differentiation program of human adipocytes inducing browning
    E Kristof
    Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary
    Transl Psychiatry 6:e963. 2016
    ..Furthermore, clozapine significantly upregulated ELOVL3, CIDEA, CYC1, PGC1A and TBX1 genes but not ZIC1 suggesting induction of the beige-like and not the classical brown ..
  14. doi Ldb1 Regulates Energy Homeostasis During Diet-Induced Obesity
    Christine Loyd
    1 Comprehensive Diabetes Center and Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Alabama at Birmingham, Birmingham, AL 35294
    Endocrinology . 2016
    ..energy expenditure during DIO was associated with significantly altered BAT gene expression, specifically Cidea, Elovl3, Cox7a1, and Dio2...
  15. ncbi Competition between neighboring topogenic signals during membrane protein insertion into the ER
    Magnus Monné
    Department of Biochemistry and Biophysics, Stockholm University, Sweden
    FEBS J 272:28-36. 2005
    ..tail and the lumenal domain following the second transmembrane segment (TM2) in the multispanning mouse protein Cig30. In the wild-type protein, the N-terminal tail translocates across the membrane before the downstream lumenal ..
  16. doi Dietary oleanolic acid mediates circadian clock gene expression in liver independently of diet and animal model but requires apolipoprotein A1
    Clara Gabás-Rivera
    Departamento Bioquímica y Biología Molecular y Celular, Facultad de Veterinaria, Instituto de Investigación Sanitaria de Aragón IIS, Universidad de Zaragoza, Spain CIBER de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Spain
    J Nutr Biochem 24:2100-9. 2013
    ..Bmal1 and the other core component of the circadian clock, Clock, together with Elovl3, Tubb2a and Cldn1 expressions, were significantly increased, while Amy2a5, Usp2, Per3 and Thrsp were significantly ..
  17. doi The SNP in the promoter region of the bovine ELOVL5 gene influences economic traits including subcutaneous fat thickness
    Hirokazu Matsumoto
    Laboratory of Animal Breeding and Genetics, Graduate School of Agricultural Science, Kobe University, Kobe 657 8501, Japan
    Mol Biol Rep 40:3231-7. 2013
    ..As a result, five synonymous mutations were detected in the coding regions of the ELOVL1, ELOVL2, ELOVL3 and ELOVL5 genes. In addition, six mutations were identified in promoter region of the ELOVL5...
  18. pmc Control of somatic tissue differentiation by the long non-coding RNA TINCR
    Markus Kretz
    The Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 493:231-5. 2013
    ..genes, many of which are mutated in human skin diseases, including FLG, LOR, ALOXE3, ALOX12B, ABCA12, CASP14 and ELOVL3. TINCR-deficient epidermis lacked terminal differentiation ultrastructure, including keratohyalin granules and ..
  19. doi Very long-chain-fatty acids enhance adipogenesis through coregulation of Elovl3 and PPARγ in 3T3-L1 cells
    Takeshi Kobayashi
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka, Japan
    Am J Physiol Endocrinol Metab 302:E1461-71. 2012
    Here, we show that Elovl3 (elongation of very long-chain fatty acids 3) was involved in the regulation of the progression of adipogenesis through activation of peroxisome proliferator-activated receptor (PPAR)γ in mouse adipocytic 3T3-L1 ..
  20. pmc Assessment of the psoriatic transcriptome in a large sample: additional regulated genes and comparisons with in vitro models
    Johann E Gudjonsson
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Invest Dermatol 130:1829-40. 2010
    ..369 downregulated), of which over 600 are to our knowledge previously unreported, including S100A7A, THRSP, and ELOVL3. Strongly upregulated genes included SERPINB4, PI3, DEFB4, and several S100-family members...
  21. doi TCF/Lef1-mediated control of lipid metabolism regulates skin barrier function
    Dagmar Fehrenschild
    Center for Molecular Medicine Cologne CMMC, University of Cologne, Cologne, Germany
    J Invest Dermatol 132:337-45. 2012
    ..Molecular analysis revealed that TCF/Lef1 signaling regulates expression of lipid-modifying enzymes, such as Elovl3 and stearoyl coenzyme A desaturase 1 (SCD1), which are key regulators of barrier function...
  22. ncbi Elovl3: a model gene to dissect homeostatic links between the circadian clock and nutritional status
    Ana Anzulovich
    Unit on Temporal Gene Expression, Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    J Lipid Res 47:2690-700. 2006
    The ELOVL3 protein is a very long-chain fatty acid elongase found in liver, skin, and brown adipose tissues...
  23. ncbi N-tail translocation in a eukaryotic polytopic membrane protein: synergy between neighboring transmembrane segments
    M Monne
    Department of Biochemistry, Stockholm University, Stockholm, Sweden
    Eur J Biochem 263:264-9. 1999
    We have used the natural N-glycosylation site in the N-tail of cig30, a eukaryotic polytopic membrane protein, as a marker for N-tail translocation across the microsomal membrane...
  24. ncbi Cig30 and Pitx3 genes are arranged in a partially overlapping tail-to-tail array resulting in complementary transcripts
    P Tvrdik
    The Wenner Gren Institute, Arrhenius Laboratories F3, Stockholm University, S 106 91 Stockholm, Sweden
    J Biol Chem 274:26387-92. 1999
    The mouse Cig30 gene codes for a 30-kDa membrane glycoprotein, which appears to have a role in the recruitment of brown adipose tissue...
  25. pmc Role of a new mammalian gene family in the biosynthesis of very long chain fatty acids and sphingolipids
    P Tvrdik
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    J Cell Biol 149:707-18. 2000
    ..The Ssc1 gene appears to be ubiquitously expressed, whereas Ssc2 and Cig30 show a restricted expression pattern...
  26. ncbi A double-deletion mutation in the Pitx3 gene causes arrested lens development in aphakia mice
    D K Rieger
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts, 02115, USA
    Genomics 72:61-72. 2001
    ..5 to newborn (5 +/- 1% of the wildtype levels at E13.5), while an involvement of the flanking Gbf1 and Cig30 genes in the aberrant lens development is highly unlikely based on expression analysis...
  27. ncbi Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs
    Takashi Matsuzaka
    Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki 305 8575, Japan
    J Lipid Res 43:911-20. 2002
    ..and characterized a murine cDNA clone that is highly similar to a fatty acyl-CoA elongase gene family such as Cig30, Sscs, and yeast ELOs...
  28. ncbi Role for ELOVL3 and fatty acid chain length in development of hair and skin function
    Rolf Westerberg
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    J Biol Chem 279:5621-9. 2004
    ..Here, we report that the Elovl3 gene product, which belongs to a highly conserved family of microsomal enzymes involved in the formation of very ..
  29. ncbi Differential regulation of fatty acid elongation enzymes in brown adipocytes implies a unique role for Elovl3 during increased fatty acid oxidation
    Andreas Jakobsson
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 10691 Stockholm, Sweden
    Am J Physiol Endocrinol Metab 289:E517-26. 2005
    The expression of the Elovl3 gene, which belongs to the Elovl gene family coding for microsomal enzymes involved in very long-chain fatty acid (VLCFA) elongation, is dramatically increased in mouse brown adipose tissue upon cold ..
  30. ncbi ELOVL3 is an important component for early onset of lipid recruitment in brown adipose tissue
    Rolf Westerberg
    Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    J Biol Chem 281:4958-68. 2006
    During the recruitment process of brown adipose tissue, the mRNA level of the fatty acyl chain elongase Elovl3 is elevated more than 200-fold in cold-stressed mice...
  31. doi Ablation of the very-long-chain fatty acid elongase ELOVL3 in mice leads to constrained lipid storage and resistance to diet-induced obesity
    Damir Zadravec
    Wenner Gren Institute, Stockholm University, Stockholm, Sweden
    FASEB J 24:4366-77. 2010
    ..The fatty acid elongase ELOVL3 is involved in the synthesis of C20-C24 saturated and monounsaturated VLCFAs mainly in liver, brown and white ..
  32. ncbi ELOVL2 overexpression enhances triacylglycerol synthesis in 3T3-L1 and F442A cells
    Tsutomu Kobayashi
    Wenner Gren Institute, Arrhenius Laboratories F3, Stockholm University, Stockholm, Sweden
    FEBS Lett 581:3157-63. 2007
    ..of very long-chain fatty acids (ELOVL) members were overexpressed in two preadipocyte cell lines, ELOVL2 and ELOVL3 in 3T3-L1 cells, and ELOVL1-3 in F442A cells...
  33. ncbi Norepinephrine and rosiglitazone synergistically induce Elovl3 expression in brown adipocytes
    Johanna A Jorgensen
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 10691, Stockholm, Sweden
    Am J Physiol Endocrinol Metab 293:E1159-68. 2007
    The Elovl3 gene, which putatively encodes for a protein involved in the elongation of saturated and monounsaturated fatty acids in the C20-C24 range, is expressed in murine liver, skin, and brown adipose tissue (BAT)...
  34. doi Steroid hormones control circadian Elovl3 expression in mouse liver
    Annelie Brolinson
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 10691 Stockholm, Sweden
    Endocrinology 149:3158-66. 2008
    The Elovl3 gene belongs to the Elovl gene family, which encodes for enzymes involved in the elongation of very long chain fatty acids...
  35. pmc HOS3, an ELO-like gene, inhibits effects of ABA and implicates a S-1-P/ceramide control system for abiotic stress responses in Arabidopsis thaliana
    Tanya M Quist
    Center for Plant Environmental Stress Physiology, Purdue University, West Lafayette, IN 47907 2010, USA
    Mol Plant 2:138-51. 2009
    ..that the disrupted gene is at locus At4g36830, annotated as encoding a putative protein with high homology to CIG30 (ELO2/FEN1)...
  36. pmc Transcript profiling and lipidomic analysis of ceramide subspecies in mouse embryonic stem cells and embryoid bodies
    Hyejung Park
    School of Biology and Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA
    J Lipid Res 51:480-9. 2010
    ..EBs had higher mRNAs for fatty acyl-CoA elongases that produce C18-, C24-, and C26-fatty acyl-CoAs (Elovl3 and Elovl6), and higher amounts of these cosubstrates for CerS...
  37. doi Discovery of novel benzoxazinones as potent and orally active long chain fatty acid elongase 6 inhibitors
    Takashi Mizutani
    Tsukuba Research Institute, Merck Research Laboratories, Banyu Pharmaceutical Co, Ltd, Okubo 3, Tsukuba, Ibaraki 300 2611, Japan
    J Med Chem 52:7289-300. 2009
    ..selective inhibitory activity toward human ELOVL6 while displaying potent inhibitory activity toward both mouse ELOVL3 and 6 enzymes. Compound (S)-1y showed acceptable pharmacokinetic profiles after oral dosing in mice...
  38. doi The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice
    Herve Guillou
    Integrative Toxicology and Metabolism, Pôle de Toxicologie Alimentaire, Laboratoire de Pharmacologie et Toxicologie, Institut National de la Recherche Agronomique INRA UR66, Toulouse Cedex 3, France
    Prog Lipid Res 49:186-99. 2010
    ..More recently, several transgenic mouse models lacking either an elongase (Elovl3(-/-), Elovl4(-/-), Elovl5(-/-), Elovl6(-/-)) or a desaturase (Scd-1(-/-), Scd-2(-/-), Fads2(-/-)) have been ..
  39. ncbi Cig30, a mouse member of a novel membrane protein gene family, is involved in the recruitment of brown adipose tissue
    P Tvrdik
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, S 106 91 Stockholm, Sweden
    J Biol Chem 272:31738-46. 1997
    ..This gene, termed Cig30, is the first mammalian member of a novel gene family comprising several nematode and yeast genes, such as SUR4 ..