ELOVL2

Summary

Gene Symbol: ELOVL2
Description: ELOVL fatty acid elongase 2
Alias: SSC2, elongation of very long chain fatty acids protein 2, 3-keto acyl-CoA synthase ELOVL2, ELOVL FA elongase 2, elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2, very long chain 3-ketoacyl-CoA synthase 2, very long chain 3-oxoacyl-CoA synthase 2
Species: human

Top Publications

  1. ncbi Elongation of long-chain fatty acids
    Amanda E Leonard
    Strategic Research, Ross Products Division, Abbott Laboratories, 625 Cleveland Avenue, Columbus, OH 43215, USA
    Prog Lipid Res 43:36-54. 2004
  2. ncbi Fatty acid elongases in mammals: their regulation and roles in metabolism
    Andreas Jakobsson
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 10691 Stockholm, Sweden
    Prog Lipid Res 45:237-49. 2006
  3. pmc A genome-wide perspective of genetic variation in human metabolism
    Thomas Illig
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Nat Genet 42:137-41. 2010
  4. doi Genomic organization, expression and evolution of porcine CRSP1, 2, and 3
    A H Rezaeian
    National Institute of Agrobiological Sciences, Tsukuba, Japan
    Cytogenet Genome Res 121:41-9. 2008
  5. ncbi Quantitative trait loci mapping for fatty acid composition traits in perirenal and back fat using a Japanese wild boar x Large White intercross
    M Nii
    Livestock Research Institute, Tokushima Agriculture, Forestry and Fisheries Technology Support Center, Anan, Tokushima 774 0047, Japan
    Anim Genet 37:342-7. 2006
  6. ncbi Liver X receptor alpha and beta genes have the potential role on loin lean and fat content in pigs
    M Yu
    Department of Animal Science, Iowa State University, Ames, 50011, USA
    J Anim Breed Genet 123:81-8. 2006
  7. ncbi Mapping in pig of genes involved in sexual differentiation: AMH, WT1, FTZF1, SOX2, SOX9, AHC, and placental and embryonic CYP19
    Y Lahbib-Mansais
    INRA, Laboratoire de Génétique Cellulaire BP27, Castanet Tolosan, France
    Cytogenet Cell Genet 76:109-14. 1997
  8. pmc Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids
    A E Leonard
    Department of Strategic Discovery Research, Ross Products Division, Abbott Laboratories, 3300 Stelzer Road, Columbus, OH 43219, USA
    Biochem J 350:765-70. 2000
  9. ncbi [Mapping quantitative trait loci for meat quality trait in a Large White x Meishan cross]
    Yu Hong Su
    College of Animal Science and Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China
    Yi Chuan Xue Bao 31:132-6. 2004
  10. ncbi Quantitative trait loci mapping for meat quality and muscle fiber traits in a Japanese wild boar x Large White intercross
    M Nii
    Livestock Research Institute, Tokushima Agriculture, Forestry and Fisheries Technology Center, Anan, Tokushima 774 0047, Japan
    J Anim Sci 83:308-15. 2005

Scientific Experts

Detail Information

Publications123 found, 100 shown here

  1. ncbi Elongation of long-chain fatty acids
    Amanda E Leonard
    Strategic Research, Ross Products Division, Abbott Laboratories, 625 Cleveland Avenue, Columbus, OH 43215, USA
    Prog Lipid Res 43:36-54. 2004
  2. ncbi Fatty acid elongases in mammals: their regulation and roles in metabolism
    Andreas Jakobsson
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 10691 Stockholm, Sweden
    Prog Lipid Res 45:237-49. 2006
    ..monounsaturated VLCFA (ELOVL1, 3 and 6) and (b) enzymes which are elongases of polyunsaturated fatty acids (PUFA) (ELOVL2, 4 and 5). All the elongases exhibit specific spatial and temporal expression...
  3. pmc A genome-wide perspective of genetic variation in human metabolism
    Thomas Illig
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Nat Genet 42:137-41. 2010
    ..For eight out of nine replicated loci (FADS1, ELOVL2, ACADS, ACADM, ACADL, SPTLC3, ETFDH and SLC16A9), the genetic variant is located in or near genes encoding enzymes ..
  4. doi Genomic organization, expression and evolution of porcine CRSP1, 2, and 3
    A H Rezaeian
    National Institute of Agrobiological Sciences, Tsukuba, Japan
    Cytogenet Genome Res 121:41-9. 2008
    ..RH mapping of CRSPs demonstrated that they resided in a region of swine chromosome 2 (SSC2). The arrangement of the genes in the region was found to be conserved in corresponding human and mouse regions...
  5. ncbi Quantitative trait loci mapping for fatty acid composition traits in perirenal and back fat using a Japanese wild boar x Large White intercross
    M Nii
    Livestock Research Institute, Tokushima Agriculture, Forestry and Fisheries Technology Support Center, Anan, Tokushima 774 0047, Japan
    Anim Genet 37:342-7. 2006
    ..QTL for fatty acid composition in perirenal fat were mapped on SSC2, 3, 4, 5, 6, 14, 16 and X. QTL for melting point (in back fat samples) were mapped on SSC1, 2 and 15...
  6. ncbi Liver X receptor alpha and beta genes have the potential role on loin lean and fat content in pigs
    M Yu
    Department of Animal Science, Iowa State University, Ames, 50011, USA
    J Anim Breed Genet 123:81-8. 2006
    ..a three-generation resource family of a cross between the Berkshire and Yorkshire (BY) pig breeds assigned LXRA to SSC2 and LXRB to SSC6...
  7. ncbi Mapping in pig of genes involved in sexual differentiation: AMH, WT1, FTZF1, SOX2, SOX9, AHC, and placental and embryonic CYP19
    Y Lahbib-Mansais
    INRA, Laboratoire de Génétique Cellulaire BP27, Castanet Tolosan, France
    Cytogenet Cell Genet 76:109-14. 1997
    ..hybridization: AMH (Anti-Müllerian Hormone) and WT1 (Wilms' Tumor gene 1) were both mapped to pig chromosome 2 (SSC2) in the q14-->q21 and p14-->q11 regions, placental CYP19 (cytochrome P450, subfamily XIX) and FTZF1 (fushi ..
  8. pmc Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids
    A E Leonard
    Department of Strategic Discovery Research, Ross Products Division, Abbott Laboratories, 3300 Stelzer Road, Columbus, OH 43219, USA
    Biochem J 350:765-70. 2000
    ..Furthermore, the HELO1 gene is located on chromosome 6, best known for encoding the major histocompatibility complex, which is essential to the human immune response...
  9. ncbi [Mapping quantitative trait loci for meat quality trait in a Large White x Meishan cross]
    Yu Hong Su
    College of Animal Science and Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China
    Yi Chuan Xue Bao 31:132-6. 2004
    ..of 1998, QTL for moisture content at chromosome-wide level was on SSC6 and in jointed populations were on SSC2, 6 and 7...
  10. ncbi Quantitative trait loci mapping for meat quality and muscle fiber traits in a Japanese wild boar x Large White intercross
    M Nii
    Livestock Research Institute, Tokushima Agriculture, Forestry and Fisheries Technology Center, Anan, Tokushima 774 0047, Japan
    J Anim Sci 83:308-15. 2005
    ..that QTL (<1% genome-wise error rate) affected the proportion of the number of type IIA muscle fibers on SSC2, the number of type IIB on SSC14, the relative area (RA) of type I on SSCX, the RA of type IIA on SSC6, the RA of ..
  11. ncbi A QTL affecting daily feed intake maps to Chromosome 2 in pigs
    Ross D Houston
    Aberdeen Centre for Energy Regulation and Obesity ACERO, Energy Balance and Obesity Division, Rowett Research Institute, Bucksburn, Aberdeen AB21 9SB, Scotland, UK
    Mamm Genome 16:464-70. 2005
    ..A QTL with a significant effect on daily feed intake (DFI) was identified on Sus scrofa Chromosome 2 (SSC2)...
  12. doi Quantitative trait loci for porcine white blood cells and platelet-related traits in a White Duroc x Erhualian F resource population
    S Yang
    Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China, Jiangxi Agricultural University, Nanchang, China
    Anim Genet 40:273-8. 2009
    ..traits, including eight genome-wide significant QTL for white blood cells and differential leucocyte counts on SSC2, 7, 8, 12 and 15 and six significant QTL for platelet-related traits on SSC2, 8, 13 and X...
  13. doi Genomic structure, chromosomal localization and expression profile of a porcine long non-coding RNA isolated from long SAGE libraries
    H Ren
    Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of Education of China, Huazhong Agricultural University, Wuhan 430070, China
    Anim Genet 40:499-508. 2009
    ..Using the INRA-University of Minnesota porcine radiation hybrid panel, TncRNA was assigned to SSC2 and found to be closely linked to the microsatellite marker SW256...
  14. doi A genome scan for quantitative trait loci affecting the length of small intestine in a White Duroc x Chinese Erhualian intercross resource population
    J Gao
    Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China, Jiangxi Agricultural University, Nanchang, China
    J Anim Breed Genet 127:119-24. 2010
    ..10 QTL for this trait were identified on 8 pig chromosomes (SSC), including four 1% genome-wide significant QTL on SSC2, 4, 7 and 8, one 5% genome-wide significant QTL on SSC12, and five 5% chromosome-wide significant QTL on SSC5, 7, ..
  15. doi Microsatellite mapping of quantitative trait loci affecting meat quality, stress hormones and production traits in Duroc × Large White F2 pigs
    M P Sanchez
    INRA, UMR1313 Genetique Animale et Biologie Integrative, F 78350 Jouy en Josas, France
    Animal 5:167-74. 2011
    ..For production traits, 33 QTL were detected on all autosomes except SSC6, 8 and 9. Seven of these QTL, located on SSC2, 3, 10, 13, 16 and 17, exceeded the genome-wide significance threshold...
  16. doi A two-step approach to map quantitative trait loci for meat quality in connected porcine F(2) crosses considering main and epistatic effects
    P Stratz
    Institute of Animal Husbandry and Breeding, University of Hohenheim, D 70599, Stuttgart, Germany
    Anim Genet 44:14-23. 2013
    ..Epistasis was significant for the pairwise QTL on SSC12 and SSC14 for pH24 and for the QTL on SSC2 and SSC5 for rigour. Some evidence for additional pairwise epistatic effects was found, although not significant...
  17. doi Functional characterization of the chicken fatty acid elongases
    Melissa K Gregory
    Rheumatology Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia
    J Nutr 143:12-6. 2013
    ..elongases are potential control points in the conversion of ALA to DHA in rats, we examined the chicken elongases, ELOVL2 and ELOVL5, which had not been characterized...
  18. doi Selection for high muscle fat in rainbow trout induces potentially higher chylomicron synthesis and PUFA biosynthesis in the intestine
    Biju Sam Kamalam
    INRA, UR1067 Nutrition Metabolism Aquaculture, F 64310 Saint Pée sur Nivelle, France
    Comp Biochem Physiol A Mol Integr Physiol 164:417-27. 2013
    ..Significantly, the F line exhibited higher intestinal mRNA levels of MTP, ApoA4, Elovl2, Elovl5 and D6D than the L line, linked to chylomicron assembly and fatty acid bioconversion...
  19. pmc Changes in the daily rhythm of lipid metabolism in the diabetic retina
    Qi Wang
    Department of Physiology, Michigan State University, East Lansing, Michigan, United States of America
    PLoS ONE 9:e95028. 2014
    ..Diabetic retinas lost Elovl4 rhythmic oscillation and had lower amplitude of Elovl2 oscillations...
  20. pmc Genome-wide age-related changes in DNA methylation and gene expression in human PBMCs
    Wilma T Steegenga
    Division of Human Nutrition, Wageningen University, Bomenweg 2, Wageningen, 6703 HD, The Netherlands
    Age (Dordr) 36:9648. 2014
    ..Age-related differential methylation of previously reported epigenetic biomarkers of aging including ELOVL2, FHL2, PENK, and KLF14 was confirmed in our study, but these genes did not display an age-related change in gene ..
  21. doi Evaluation of the causality of the low-density lipoprotein receptor gene (LDLR) for serum lipids in pigs
    Z Zeng
    Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China, Jiangxi Agricultural University, Nanchang, 330045, China
    Anim Genet 45:665-73. 2014
    ..lipoprotein cholesterol (LDL-C) and total cholesterol (TC) was identified around the LDLR gene on chromosome 2 (SSC2) in a White Duroc × Erhualian F2 resource population and Sutai pigs in our previous study...
  22. doi Genome-wide SNP scan in a porcine Large White×Minzhu intercross population reveals a locus influencing muscle mass on chromosome 2
    Xin Liu
    Key Laboratory of Farm Animal Genetic Resources and Germplasm Innovation of Ministry of Agriculture of China, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China
    Anim Sci J 85:969-75. 2014
    ..of the strongest associated SNP is included as a fixed effect in the model, showed that those significant SNPs on SSC2 were derived from a single quantitative trait locus...
  23. doi Genomewide association and identification of candidate genes for ovulation rate in swine
    J F Schneider
    USDA, ARS, U S Meat Animal Research Center, Clay Center, NE 68933
    J Anim Sci 92:3792-803. 2014
    ..01). Ten QTL were found on SSC1, 12 on SSC2, 4 on SSC3, 8 on SSC4, 3 on SSC5, 3 on SSC6, 3 on SSC7, 4 on SSC8, 2 on SSC9, 4 on SSC10, 1 on SSC12, 4 on SSC13, 2 ..
  24. doi Examination of DNA methylation status of the ELOVL2 marker may be useful for human age prediction in forensic science
    Renata Zbieć-Piekarska
    Central Forensic Laboratory of the Police, Aleje Ujazdowskie 7, 00 583 Warsaw, Poland
    Forensic Sci Int Genet 14:161-7. 2015
    ..this study, we optimized an assay based on bisulfite conversion and pyrosequencing of 7 CpG sites located in the ELOVL2 gene...
  25. doi Atlantic salmon (Salmo salar) liver transcriptome response to diets containing Camelina sativa products
    Xi Xue
    Department of Ocean Sciences, Memorial University of Newfoundland, 1 Marine Lab Road, St John s, NL A1C 5S7, Canada
    Comp Biochem Physiol Part D Genomics Proteomics 14:1-15. 2015
    ..btg1, dnph1, lect-2, clra, klf9, and fadsd6a], and three additional genes involved in lipid metabolism [elovl2, elovl5 (2 paralogues), and fadsd5], were subjected to QPCR with liver templates from all 5 dietary treatments...
  26. doi Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood
    Tina Rönn
    Department of Clinical Sciences, Epigenetics and Diabetes and
    Hum Mol Genet 24:3792-813. 2015
    ..g. FHL2, NOX4 and PLG). Interestingly, many reported epigenetic biomarkers of aging in blood, including ELOVL2, FHL2, KLF14 and GLRA1, also showed significant correlations between adipose tissue DNA methylation and age in our ..
  27. pmc Improved age determination of blood and teeth samples using a selected set of DNA methylation markers
    Bram Bekaert
    a KU Leuven University of Leuven Department of Imaging and Pathology Leuven, Belgium
    Epigenetics 10:922-30. 2015
    ..From the published literature we selected 4 age-associated genes (ASPA, PDE4C, ELOVL2, and EDARADD) and determined CpG methylation levels from 206 blood samples of both deceased and living individuals ..
  28. doi Polyunsaturated fatty acid biosynthesis is involved in phenylephrine-mediated calcium release in vascular smooth muscle cells
    Nicola A Irvine
    Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK
    Prostaglandins Leukot Essent Fatty Acids 101:31-9. 2015
    ..6 (D6d) and Δ5 (D5d) desaturase, and elongase (Elovl) 5 were expressed. Elovl2 was not detected in human, mouse or rat VSM cells, or in rat or mouse aortae, but tit was not associated with ..
  29. pmc Using the Coriell Personalized Medicine Collaborative Data to conduct a genome-wide association study of sleep duration
    Laura B Scheinfeldt
    Coriell Institute for Medical Research, Camden, New Jersey
    Am J Med Genet B Neuropsychiatr Genet 168:697-705. 2015
    ..In addition, we have identified novel candidate genes for involvement in sleep duration including SORCS1 and ELOVL2. Our results demonstrate that the self-reported data collected through the CPMC are robust, and our genome-wide ..
  30. doi Hepatic fatty acid biosynthesis is more responsive to protein than carbohydrate in rainbow trout during acute stimulations
    WeiWei Dai
    Institut National de la Recherche Agronomique, UR 1067 Nutrition Métabolisme, Aquaculture, Aquapole, CD 918, Saint Pée sur Nivelle, France
    Am J Physiol Regul Integr Comp Physiol 310:R74-86. 2016
    ..and ATP citrate lyase (ACLY)], lipid bioconversion [elongation of very long chain fatty acids like-5 (Elovl5), Elovl2, Δ6 fatty acyl desaturase (D6D) and stearoyl-CoA desaturase-1 (SCD1)], NADPH production [glucose-6-phosphate ..
  31. doi Twenty years of artificial directional selection have shaped the genome of the Italian Large White pig breed
    G Schiavo
    Department of Agricultural and Food Sciences, Division of Animal Sciences, University of Bologna, Viale Fanin 46, 40127, Bologna, Italy
    Anim Genet 47:181-91. 2016
    ..The largest proportion of the 493 SNPs was on porcine chromosome (SSC) 7, SSC2, SSC8 and SSC18 for a total of 204 haploblocks...
  32. doi Genome-wide association study reveals regions associated with gestation length in two pig populations
    A M Hidalgo
    Animal Breeding and Genomics Centre, Wageningen University, P O Box 338, 6700 AH, Wageningen, The Netherlands
    Anim Genet 47:223-6. 2016
    ..For LW, four associated SNPs were detected in one region of 0.14 Mbp on SSC5. The region on SSC2 contains the heparin-binding EGF-like growth factor (HBEGF) gene, which promotes embryo implantation and has been ..
  33. pmc Evolutionary functional elaboration of the Elovl2/5 gene family in chordates
    Oscar Monroig
    Institute of Aquaculture, School of Natural Sciences, University of Stirling, Stirling FK9 4LA, Scotland, UK
    Sci Rep 6:20510. 2016
    ..Here we examine key components of the LC-PUFA cascade, the Elovl2/Elovl5 elongases, from amphioxus, an invertebrate chordate, the sea lamprey, a representative of agnathans, and ..
  34. doi Nutritional regulation of long-chain PUFA biosynthetic genes in rainbow trout (Oncorhynchus mykiss)
    Melissa K Gregory
    1Rheumatology Unit, Royal Adelaide Hospital, Adelaide, SA 5000, Australia
    Br J Nutr 115:1721-9. 2016
    ..of fatty acyl desaturase (FADS)2a(Δ6), FADS2b(Δ5), elongation of very long-chain fatty acid (ELOVL)5 and ELOVL2 was examined after 3 weeks of dietary intervention...
  35. doi Forensic age prediction for dead or living samples by use of methylation-sensitive high resolution melting
    Yuya Hamano
    Department of Forensic Medicine, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan Forensic Science Laboratory, Kyoto Prefectural Police Headquarters, Kamigyo ku, Kyoto, Japan
    Leg Med (Tokyo) 21:5-10. 2016
    ..In this study, a wide range methylation status in the ELOVL2 and FHL2 promoter regions were detected with methylation-sensitive high resolution melting (MS-HRM) in a labor-, ..
  36. pmc Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses
    Valerio Chiurchiù
    Department of Medicine, Campus Bio Medico University of Rome, 00128 Rome, Italy European Center for Brain Research, Laboratory of Neurochemistry of Lipids, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Santa Lucia Foundation, 00143 Rome, Italy
    Sci Transl Med 8:353ra111. 2016
    ..These results were also supported in vivo in a mouse deficient for DHA synthesis (Elovl2(-/-)) that showed an increase in TH1/TH17 cells and a decrease in Treg cells compared to wild-type mice...
  37. pmc Donor age and C1orf132/MIR29B2C determine age-related methylation signature of blood after allogeneic hematopoietic stem cell transplantation
    Magdalena Spolnicka
    Biology Department, Central Forensic Laboratory of the Police, Warsaw, 00 583 Poland
    Clin Epigenetics 8:93. 2016
    Our recent study demonstrated that DNA methylation status in a set of CpGs located in ELOVL2, C1orf132, TRIM59, KLF14, and FHL2 can accurately predict calendar age in blood...
  38. pmc E2F1 Orchestrates Transcriptomics and Oxidative Metabolism in Wharton's Jelly-Derived Mesenchymal Stem Cells from Growth-Restricted Infants
    Peck Yean Tan
    Singapore Institute for Clinical Sciences, Agency for Science Technology and Research A STAR, Singapore, Singapore
    PLoS ONE 11:e0163035. 2016
    ..One of the key genes regulated by E2F1 was found to be the fatty acid elongase ELOVL2, a gene involved in the endogenous synthesis of docosahexaenoic acid (DHA)...
  39. doi Prepubertal heifers versus cows-The differences in the follicular environment
    E Warzych
    Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Poznan, Poland Electronic address
    Theriogenology 87:36-47. 2017
    ..LDs) number in oocytes, expression of seven genes involved in energy metabolism (fatty acids [FAs] metabolism-ELOVL2, ELOVL5, SCD, FADS2, glucose transport-GLUT1, GLUT3, GLUT8) in CC and GC as well as FA composition and glucose ..
  40. ncbi Systemic Age-Associated DNA Hypermethylation of ELOVL2 Gene: In Vivo and In Vitro Evidences of a Cell Replication Process
    Maria Giulia Bacalini
    Department of Experimental, Diagnostic and Specialty Medicine and Interdepartmental Center L Galvani, University of Bologna, Bologna, Italy Personal Genomics S r l, Verona, Italy
    J Gerontol A Biol Sci Med Sci . 2016
    ..We recently demonstrated that DNA methylation of ELOVL2 and FHL2 CpG islands is highly correlated with age in whole blood...
  41. doi Regulation of crucial lncRNAs in differentiation of chicken embryonic stem cells to spermatogonia stem cells
    D Li
    Jiangsu Province Key Laboratory of Animal Breeding and Molecular Design, College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, China
    Anim Genet . 2016
    ..Based on wego and string analyses, we found lnc-SSC1, lnc-SSC5, lnc-SSC2 and lnc-ESC2 negatively regulated target genes SUFU, EPHA3, KLF3, ARL3 and TRIM8, whereas SHH, NOTCH, TGF-β, cAMP/..
  42. ncbi Porcine BAC derived microsatellites linked to ADRBK1, CNTF and GAL on SSC2
    M Faivre
    Department of Animal Sciences, Animal Breeding and Genetics Group, Wageningen Institute of Animal Sciences, Wageningen University, PO Box 338 6700 AH Wageningen, The Netherlands
    Anim Genet 33:72-3. 2002
  43. ncbi Joint analysis of two breed cross populations in pigs to improve detection and characterization of quantitative trait loci
    J J Kim
    Department of Animal Science, Center for Integrated Animal Genomics, Iowa State University, Ames, 50011, USA
    J Anim Sci 83:1229-40. 2005
    ..Presence of paternally expressed QTL near the IGF2 region of SSC2 was confirmed, with major effects on backfat and loin muscle area, particularly in the UOI population, as well as ..
  44. ncbi Assignment of 117 genes from HSA5 to the porcine IMpRH map and generation of a dense human-pig comparative map
    T Shimogiri
    Faculty of Agriculture, Kagoshima University, Kagoshima, 890 0065, Japan
    Anim Genet 37:503-8. 2006
    ..Sixty-six genes were assigned to SSC2 and 48 to SSC16. One gene was suggested to link to SSC2 markers and another to SSC6...
  45. ncbi Effect of exercise on hepatic gene expression in an obese mouse model using cDNA microarrays
    Kyoung Young Lee
    Department of Physical Education, College of Education, Seoul National University, Seoul, Korea
    Obesity (Silver Spring) 14:1294-302. 2006
    ..Our study showed beneficial effects of exercise training in preventing the development of obesity and metabolic disorders in mice with diet-induced obesity...
  46. doi The SNP in the promoter region of the bovine ELOVL5 gene influences economic traits including subcutaneous fat thickness
    Hirokazu Matsumoto
    Laboratory of Animal Breeding and Genetics, Graduate School of Agricultural Science, Kobe University, Kobe 657 8501, Japan
    Mol Biol Rep 40:3231-7. 2013
    ..As a result, five synonymous mutations were detected in the coding regions of the ELOVL1, ELOVL2, ELOVL3 and ELOVL5 genes. In addition, six mutations were identified in promoter region of the ELOVL5...
  47. doi Dietary and ontogenic regulation of fatty acid desaturase and elongase expression in broiler chickens
    M Jing
    Department of Animal Science, University of Manitoba, Winnipeg, MB, Canada R3T 2N2
    Prostaglandins Leukot Essent Fatty Acids 89:107-13. 2013
    ..Total n-6 PUFA decreased, and n-3 PUFA increased in response to a decrease in the dietary LA:ALA. FADS1, FADS2, ELOVL2 and ELOVL5 mRNAs were highest (P<0.05) in birds fed lower LA:ALA diets...
  48. pmc Molecular basis for differential elongation of omega-3 docosapentaenoic acid by the rat Elovl5 and Elovl2
    Melissa K Gregory
    Rheumatology Unit, Royal Adelaide Hospital, SA, Australia
    J Lipid Res 54:2851-7. 2013
    Functional characterization of the rat elongases, Elovl5 and Elovl2, has identified that Elovl2 is crucial for omega-3 docosahexaenoic acid (DHA) (22:6n-3) synthesis...
  49. pmc Bioconversion of α-linolenic acid into n-3 long-chain polyunsaturated fatty acid in hepatocytes and ad hoc cell culture optimisation
    Ramez Alhazzaa
    School of Life and Environmental Sciences, Deakin University, Victoria, Australia
    PLoS ONE 8:e73719. 2013
    ..hour(-1)) Fads2 activity on ALA can be achieved with 81 µM initial ALA. Interestingly, the apparent activity of Elovl2 (20:5n-3 elongation) was the slowest amongst other biosynthesis steps...
  50. doi Identification of the proteins required for fatty acid desaturation in zebrafish (Danio rerio)
    Yao Sheng Chen
    Institute of Fisheries Science, National Taiwan University, Taipei 10617, Taiwan Institute of Cellular and Organismic Biology, Academia Sinica, Taipei 11529, Taiwan Institute of Chemistry, Academia Sinica, Taipei 11529, Taiwan
    Biochem Biophys Res Commun 440:671-6. 2013
    ..the Z-FADS protein exists in close proximity to certain cytochrome b5 reductases (CYB5R2 and 3) and elongases (ELOVL2, 4, 5 and 7) on the endoplasmic reticulum, as determined using fluorescence microscopy and fluorescence resonance ..
  51. pmc Genome-wide association studies with metabolomics
    Jerzy Adamski
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Experimental Genetics, Genome Analysis Center, 85764 Neuherberg, Germany
    Genome Med 4:34. 2012
    ..Recently, associations between loci such as FADS1, ELOVL2 or SLC16A9 and lipid concentrations have been explained by GWAS with metabolomics...
  52. doi Genome-wide association study of swine farrowing traits. Part II: Bayesian analysis of marker data
    J F Schneider
    U S Meat Animal Research Center, USDA ARS, 4 Clay Center, NE 68933, USA
    J Anim Sci 90:3360-7. 2012
    ..No QTL were identified for NSB or MUM. Thirty-three QTL were found for LBW, 3 on SSC1, 1 on SSC2, 1 on SSC3, 5 on SSC4, 2 on SSC5, 5 on SSC6, 3 on SSC7, 2 on SSC9, 1 on SSC10, 2 on SSC14, 6 on SSC15, and 2 on ..
  53. doi QTL analysis of back fat thickness and carcass pH in an F₂ intercross between Landrace and Korean native pigs
    Chae Kyoung Yoo
    Division of Applied Life Science Brain Korea 21 Program, Graduate School of Gyeongsang National University, Jinju 660 701, South Korea
    Mol Biol Rep 39:8327-33. 2012
    ..QTL in 9 chromosomal regions (SSC1, 2, 5, 6, 7, 8, 12, 15, and 16) and 29 suggestive QTL in 16 chromosomal regions (SSC2, 3, 4, 5, 6, 7, 8, 10, 11, 12, 14, 15, 16, 17, 18, and X)...
  54. doi Methylation of ELOVL2 gene as a new epigenetic marker of age
    Paolo Garagnani
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Aging Cell 11:1132-4. 2012
    ..whole blood DNA from a small cohort of 64 subjects of different ages, we identified 3 regions, the CpG islands of ELOVL2, FHL2, and PENK genes, whose methylation level strongly correlates with age...
  55. ncbi Molecular prognostic profile of Egyptian HCC cases infected with hepatitis C virus
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo, Egypt
    Asian Pac J Cancer Prev 13:5433-8. 2012
    ..This study provides complete genetic profile for Egyptian HCC. Genome-wide analyses were performed to identify the predictive signatures...
  56. doi Hormone-sensitive lipase deficiency disturbs the fatty acid composition of mouse testis
    M E Casado
    Servicio de Bioquímica Investigación, Hospital Universitario Ramon y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS, E 28034 Madrid, Spain
    Prostaglandins Leukot Essent Fatty Acids 88:227-33. 2013
    ..Moreover, the expression of SCD-1, FADS1, and FADS2 was increased while expression of ELOVL2, an essential enzyme for the formation of very-long PUFA in testis, was decreased...
  57. doi Coexisting role of fasting or feeding and dietary lipids in the control of gene expression of enzymes involved in the synthesis of saturated, monounsaturated and polyunsaturated fatty acids
    Maricela Rodriguez-Cruz
    Laboratorio de Biologia Molecular, Unidad de Investigación Médica en Nutrición, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, IMSS, Mexico City, Mexico
    Gene 496:28-36. 2012
    ..A higher content of LC-PUFAs was observed due to a high expression of Elovl2 and Elovl5, although Fads2 was suppressed by dietary lipids...
  58. pmc Genetic variation in fatty acid elongases is not associated with intermediate cardiovascular phenotypes or myocardial infarction
    S Aslibekyan
    Department of Community Health, Brown University, Providence, RI, USA
    Eur J Clin Nutr 66:353-9. 2012
    Elongases 2, 4 and 5, encoded by genes ELOVL2, ELOVL4 and ELOVL5, have a key role in the biosynthesis of very long chain polyunsaturated fatty acids (PUFAs)...
  59. doi Optimizing early detection of avian influenza H5N1 in backyard and free-range poultry production systems in Thailand
    Flavie L Goutard
    Centre de Cooperation Internationale en Recherche Agronomique pour le Developpement CIRAD, Département ES, UR AGIRs, TA C22 E, Campusinternational de Baillarguet, 34398 Montpellier Cedex 5, France
    Prev Vet Med 105:223-34. 2012
    ..Nationwide passive surveillance (SSC1) and risk-based clinical X-ray (SSC2) showed a similar sensitivity level, with a median sensitivity ratio of 0.96 (95% CI 0.40-15.00)...
  60. pmc Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations
    Ayse Demirkan
    Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    PLoS Genet 8:e1002490. 2012
    ..Among those, 14 loci (KCNH7, AGPAT1, PNLIPRP2, SYT9, FADS1-2-3, DLG2, APOA1, ELOVL2, CDK17, LIPC, PDXDC1, PLD2, LASS4, and APOE) mapped into the glycerophospholipid and 12 loci (ILKAP, ITGA9, AGPAT1,..
  61. doi A whole genome scan to detect quantitative trait loci for gestation length and sow maternal ability related traits in a White Duroc × Erhualian F2 resource population
    C Y Chen
    Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China, Jiangxi Agricultural University, 330045 Nanchang, China
    Animal 4:861-6. 2010
    ..13, P < 0.05). Three QTL were detected on pig chromosome (SSC)2, 8 and 12 for gestation length. The QTL on SSC2 achieved the 5% genome-wide significant level and the QTL on SSC8 was consistent with previous reports...
  62. ncbi Detecting QTL for feed intake traits and other performance traits in growing pigs in a Piétrain-Large White backcross
    H Gilbert
    1INRA, UMR1313 Genetique Animale et Biologie Integrative, F 78350 Jouy en Josas, France
    Animal 4:1308-18. 2010
    ..Three putative QTL for feed intake traits were detected (P < 0.06 at the CW level) on SSC2, SSC7 and SSC9. QTL on feeding traits had effects in the range of 0.20 phenotypic s.d...
  63. ncbi Mt-Hsp70 homolog, Ssc2p, required for maturation of yeast frataxin and mitochondrial iron homeostasis
    S A Knight
    Department of Medicine, Division of Hematology Oncology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6100, USA
    J Biol Chem 273:18389-93. 1998
    ..Yeast with ssc2-1 mutations were identified by a screen for altered iron-dependent gene regulation and mitochondrial dysfunction...
  64. pmc Evolution of the neuropeptide Y receptor family: gene and chromosome duplications deduced from the cloning and mapping of the five receptor subtype genes in pig
    A Wraith
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, SE 751 24 Uppsala, Sweden
    Genome Res 10:302-10. 2000
    ..The NPY1R, NPY2R, and NPY5R receptor genes were localized to SSC8, the NPY4R to SSC14, and NPY6R to SSC2. Our comparisons strongly suggest that the tight cluster of NPY1R, NPY2R, and NPY5R on human chromosome 4 (HSA4) ..
  65. pmc Role of a new mammalian gene family in the biosynthesis of very long chain fatty acids and sphingolipids
    P Tvrdik
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    J Cell Biol 149:707-18. 2000
    ..The Ssc1 gene appears to be ubiquitously expressed, whereas Ssc2 and Cig30 show a restricted expression pattern...
  66. pmc Genome-wide scan for body composition in pigs reveals important role of imprinting
    D J De Koning
    Animal Breeding and Genetics Group, Wageningen Institute of Animal Sciences, Wageningen University, P O Box 338, 6700 AH Wageningen, The Netherlands
    Proc Natl Acad Sci U S A 97:7947-50. 2000
    ..For back fat thickness, a paternally expressed QTL was found on Sus scrofa chromosome 2 (SSC2), and a Mendelian-expressed QTL was found on SSC7...
  67. ncbi Fine mapping and imprinting analysis for fatness trait QTLs in pigs
    A P Rattink
    Department of Animal Sciences, Animal Breeding and Genetics Group, Wageningen Institute of Animal Sciences, Wageningen University, PO Box 338 6700 AH Wageningen, The Netherlands
    Mamm Genome 11:656-61. 2000
    ..To further investigate the regions on pig Chr 2 (SSC2), SSC4, and SSC7, 25 additional markers from these regions were typed on 800 animals (619 F(2) animals, their F(1) ..
  68. ncbi A high-resolution comparative RH map of porcine chromosome (SSC) 2
    A P Rattink
    Department of Animal Sciences, Animal Breeding and Genetics Group, Wageningen Institute of Animal Sciences, Wageningen University, PO Box 338, 6700 AH, Wageningen, The Netherlands
    Mamm Genome 12:366-70. 2001
    ..In total, 16 genes from human Chromosome (HSA) 11p, HSA19p, and HSA5q were newly assigned to SSC2. One linkage group was observed at LOD 3.0, and five linkage groups at LOD 4.0...
  69. pmc Results of a whole genome scan targeting QTL for growth and carcass traits in a Piétrain x Large White intercross
    Carine Nezer
    Department of Genetics, Faculty of Veterinary Medicine, University of Liège B43, 20 Bd de Colonster, 4000 Liege, Belgium
    Genet Sel Evol 34:371-87. 2002
    ..We report experiment-wide significant lod scores (>4.6) for meatiness and fat deposition on chromosome SSC2, and for average daily gain and carcass length on chromosome SSC7. Additional suggestive lod scores (>3...
  70. ncbi Identification and expression of mammalian long-chain PUFA elongation enzymes
    Amanda E Leonard
    Ross Products Division, Abbott Laboratories, Columbus, Ohio 43215, USA
    Lipids 37:733-40. 2002
    ..4 and 58% identity, respectively, to that of ELOVL5. The open reading frame of the human clone (ELOVL2) encodes a 296-amino acid peptide, whereas the mouse clone (Elovl2) encodes a 292-amino acid peptide...
  71. ncbi A first-generation EST RH comparative map of the porcine and human genome
    Anette Rink
    Department of Animal Biotechnology, College of Agriculture, Biotechnology and Natural Resources, University of Nevada, Reno, Nevada 89557, USA
    Mamm Genome 13:578-87. 2002
    ..Six porcine chromosomes-SSC2, 5, 6, 7, 12, and 14-correspond to the three gene-richest human chromosomes, HSA17, 19, and 22, and show above ..
  72. ncbi Transcriptional response of soybean suspension-cultured cells induced by Nod factors obtained from Bradyrhizobium japonicum USDA110
    Tsuneo Hakoyama
    Faculty of Agriculture, Tokyo University of Agriculture and Technology, Saiwaicho 3 5 8, Fuchu, Tokyo 183 8509 Japan
    Plant Cell Physiol 43:1314-22. 2002
    ..Amino acid sequences deduced from full-length cDNA corresponding to ssc2 and ssc4 were investigated, and it was shown that these polypeptides were equipped with a leucine zipper motif and ..
  73. ncbi QTL mapping for growth and carcass traits in an Iberian by Landrace pig intercross: additive, dominant and epistatic effects
    L Varona
    Area de Produccio Animal, Centre UdL IRTA, c Rovira Roure 177, 25198 Lleida, Spain
    Genet Res 80:145-54. 2002
    ..The results from the genomic scan show genomewide significant QTL in SSC2 (longissimus muscle area and backfat thickness), SSC4 (length of carcass, backfat thickness, loin, shoulder and ..
  74. ncbi Development of a single nucleotide polymorphism map of porcine chromosome 2
    B J Jungerius
    Animal Breeding and Genetics Group, Wageningen University, Wageningen, The Netherlands
    Anim Genet 34:429-37. 2003
    Single nucleotide polymorphism markers are developed on SSC2, predominantly on the p-arm. Several studies reported a quantitative trait loci (QTL) for backfat thickness in this region...
  75. ncbi The value of prior information for detection of QTL affecting longitudinal traits: an example using Von Bertalanffy growth function
    L Varona
    Area de Produccio Animal, Centre UdL IRTA, Lleida, Spain
    J Anim Breed Genet 122:37-48. 2005
    ..Animals of the F2 population were genotyped for seven markers in chromosome 2 (SSC2). Two prior distributions for the mean effect of the parameters related with birth and adult weight were compared...
  76. ncbi Genome-wide identification of quantitative trait loci in a cross between Hampshire and Landrace I: carcass traits
    P Karlskov-Mortensen
    Division of Genetics, Department of Animal and Veterinary Basic Sciences, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    Anim Genet 37:156-62. 2006
    ..These QTL comprise loci affecting fat deposition and lean meat content on SSC1, 4, 9, 10, 13 and 16, a locus on SSC2 affecting the ratio between weight of meat and bone in back and weight of meat and bone in ham and two loci ..
  77. ncbi Sequence identification, tissue distribution, mapping and polymorphism of the porcine sar1b gene
    X M Wang
    College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, P R China
    Anim Biotechnol 17:99-107. 2006
    ..panel (SCHP) and the INRA-University of Minnesota porcine radiation hybrid (IMpRH) panel indicated the gene maps to SSC2 (1/2 q24)-q29 and most closely links to the interleukin-4 (IL4) gene...
  78. pmc Genome-wide linkage analysis of inguinal hernia in pigs using affected sib pairs
    Eli Grindflek
    The Norwegian Pig Breeders Association NORSVIN, Hamar, Norway
    BMC Genet 7:25. 2006
    ..The genome scan utilised affected sib pairs (ASP), and the data was analysed using both an ASP test based on Non-parametric Linkage (NPL) analysis, and a Transmission Disequilibrium Test (TDT)...
  79. ncbi Evolutionary breakpoints through a high-resolution comparative map between porcine chromosomes 2 and 16 and human chromosomes
    Yvette Lahbib-Mansais
    Institut National de la Recherche Agronomique, Laboratoire de Genetique Cellulaire, BP52627, 31326 Castanet Tolosan, France
    Genomics 88:504-12. 2006
    This study reports a high-resolution comparative map between human chromosomes and porcine chromosomes 2 (SSC2) and 16 (SSC16), pointing out new homologies and evolutionary breakpoints...
  80. ncbi Identification of quantitative trait loci affecting corpora lutea and number of teats in a Meishan x Duroc F2 resource population
    S Sato
    National Livestock Breeding Center, Nishigo, Fukushima 961 8511, Japan
    J Anim Sci 84:2895-901. 2006
    ..Using the likelihood-ratio test for a categorical trait, 2 QTL for pin nipples were detected on SSC2 and SSC16 (P < 0.01)...
  81. ncbi Detection of novel quantitative trait loci for cutaneous melanoma by genome-wide scan in the MeLiM swine model
    Zhi Qiang Du
    CEA, DSV, DRR, Laboratoire de Radiobiologie et d Etude du Génome, INRA Jouy en Josas, F 78352 France
    Int J Cancer 120:303-20. 2007
    ..4 and 88.0 cM (SSC1), 56.0 cM (SSC13), 86.5 cM (SSC15) and 39.8 cM (SSC17), and, on SSC2, at 16.9 cM, in families derived from F1 males only (p < 0.05, except for SSC13, p < 0.01)...
  82. ncbi A genome scan reveals QTL for growth, fatness, leanness and meat quality in a Duroc-Pietrain resource population
    G Liu
    Animal Breeding and Husbandry Group, Institute of Animal Science, University of Bonn, Endenicher Allee 15, 53115 Bonn, Germany
    Anim Genet 38:241-52. 2007
    ..Two QTL for trait backfat thickness were detected on SSC2; a significant paternal effect was found for a QTL in the IGF2 region while another QTL in the middle of SSC2 ..
  83. ncbi Porcine maternal infanticide as a model for puerperal psychosis
    Claire R Quilter
    Human Molecular Genetics Group, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, UK
    Am J Med Genet B Neuropsychiatr Genet 144:862-8. 2007
    ..The results identified 4 QTL mapping on Sus scrofa chromosomes 2 (SSC2), 10 (SSC10), and X (SSCX). The peak regions of these QTL are syntenic to HSA 5q14.3-15, 1q32, Xpter-Xp2.1, and Xq2...
  84. ncbi ELOVL2 overexpression enhances triacylglycerol synthesis in 3T3-L1 and F442A cells
    Tsutomu Kobayashi
    Wenner Gren Institute, Arrhenius Laboratories F3, Stockholm University, Stockholm, Sweden
    FEBS Lett 581:3157-63. 2007
    Elongation of very long-chain fatty acids (ELOVL) members were overexpressed in two preadipocyte cell lines, ELOVL2 and ELOVL3 in 3T3-L1 cells, and ELOVL1-3 in F442A cells...
  85. pmc Detection of quantitative trait loci for reproduction and production traits in Large White and French Landrace pig populations
    Thierry Tribout
    INRA UR337 Station de génétique quantitative et appliquée, 78352 Jouy en Josas, France
    Genet Sel Evol 40:61-78. 2008
    ..with medium to large effects were detected at a chromosome-wide significance level of 5% affecting traits US_M (on SSC2, SSC3 and SSC17), LWGT (on SSC4), STILLp (on SSC6, SSC11 and SSC14) and LIVp (on SSC7, SSC16 and SSC18)...
  86. doi A new 4016-marker radiation hybrid map for porcine-human genome analysis
    Noriyuki Hamasima
    Society for Techno Innovation of Agriculture, Forestry and Fisheries STAFF Institute, 446 1 Ippaizuka, Kamiyokoba, Tsukuba, Ibaraki, 305 0854, Japan
    Mamm Genome 19:51-60. 2008
    ..38 porcine terminal regions, we found that at least 20 regions have been conserved between the porcine and human genomes; we also found four paralogous regions for the major histocompatibility complex (MHC) on SSC7, SSC2, SSC4, and SSC1.
  87. doi Quantitative trait loci for chemical body composition traits in pigs and their positional associations with body tissues, growth and feed intake
    C Duthie
    Animal Breeding and Development, Sustainable Livestock Systems Group, Scottish Agricultural College, Edinburgh EH9 3JG, UK
    Anim Genet 39:130-40. 2008
    ..Three hundred and eighty-six animals from 49 families were genotyped for 51 molecular markers covering chromosomes SSC2, SSC4, SSC8, SSC9, SSC10 and SSC14...
  88. doi Full-length coding sequences, polymorphism and chromosomal localizations of the porcine EDG4 and EDG7 genes
    T L Shan
    Department of Veterinary Internal Medicine, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, PR China
    Mol Biol Rep 36:751-6. 2009
    ..Radiation hybrid mapping data indicated that EDG4 and EDG7 map to q2.1 of pig chromosome 2 (SSC2) and q2.6-3.2 of pig chromosome6 (SSC6), respectively...
  89. doi Investigating the genetic basis of pork tenderness: genomic analysis of porcine CAST
    S N Meyers
    Department of Animal Sciences, Laboratory of Molecular Genetics, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Anim Genet 39:531-43. 2008
    ..detected within the Illinois Meat Quality Pedigree (IMQP) and fine-mapped to the region of porcine chromosome 2 (SSC2) harbouring the functional candidate gene calpastatin (CAST)...
  90. doi Heritabilities and quantitative trait loci for blood gases and blood pH in swine
    G Reiner
    Department of Veterinary Clinical Sciences, University of Giessen, D 35392 Giessen, Germany
    Anim Genet 40:142-8. 2009
    ..QTL associated with CO(2) have been detected on SSC6, 7, 8 and 9, and QTL associated with O(2) on SSC2 and SSC8...
  91. doi A genome wide detection of quantitative trait loci on pig maternal infanticide behavior in a large scale White Duroc x Erhualian resource population
    Congying Chen
    Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China, Jiangxi Agricultural University, Nanchang, Jiangxi Province, People s Republic of China
    Behav Genet 39:213-9. 2009
    ..The results identified that seven chromosome regions on SSC2, SSC6, SSC14, SSC15 and SSCX were significantly linked with maternal infanticide (P < 0.05)...
  92. doi Highly unsaturated fatty acid synthesis in Atlantic salmon: characterization of ELOVL5- and ELOVL2-like elongases
    Sofia Morais
    Institute of Aquaculture, University of Stirling, Stirling, FK9 4LA, Scotland, UK
    Mar Biotechnol (NY) 11:627-39. 2009
    ..of two new elongase cDNAs: a second elovl5b elongase, corresponding to a 294-amino-acid (aa) protein, and an elovl2-like elongase, coding for a 287-aa protein, characterized for the first time in a nonmammalian vertebrate...
  93. doi Hepatic gene expression in morbidly obese women: implications for disease susceptibility
    Marshall B Elam
    Department of Medicine and Research Service, Veterans Affairs Medical Center, Memphis, Tennessee, USA
    Obesity (Silver Spring) 17:1563-73. 2009
    ..susceptibility genes were identified that encoded proteins regulating lipid and energy homeostasis (PLIN, ENO3, ELOVL2, APOF, LEPR, IGFBP1, DDIT4), signal transduction (MAP2K6, SOCS-2), postinflammatory tissue repair (HLA-DQB1, SPP1, ..
  94. pmc Mapping carcass and meat quality QTL on Sus Scrofa chromosome 2 in commercial finishing pigs
    Henri C M Heuven
    Animal Breeding and Genomics Centre, Wageningen University, Wageningen, The Netherlands
    Genet Sel Evol 41:4. 2009
    Quantitative trait loci (QTL) affecting carcass and meat quality located on SSC2 were identified using variance component methods...
  95. doi A genome-wide scan reveals candidate susceptibility loci for pig hernias in an intercross between White Duroc and Erhualian
    N S Ding
    Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China, Jiangxi Agricultural University, Nanchang, PR China
    J Anim Sci 87:2469-74. 2009
    ..analysis revealed 11 chromosomal regions on SSC1, 2, 3, 6, 7, 8, 10, and 11 for umbilical hernia and 5 regions on SSC2, 4, 8, 13, and 16 for scrotal/inguinal hernia, whereas the TDT test identified susceptibility loci for umbilical ..
  96. doi A genome scan for quantitative trait loci affecting three ear traits in a White Duroc x Chinese Erhualian resource population
    J Ma
    Key Laboratory for Animal Biotechnology of Jiangxi Province, Ministry of Agriculture of China, Jiangxi Agricultural University, Nanchang 330045, China
    Anim Genet 40:463-7. 2009
    ..Almost all the QTL for weight and area had essentially additive effects, while the QTL for erectness on SSC2, 5 and 7 showed not only additive effects but also partial dominance effects of Erhualian alleles...
  97. doi Relationships among calpastatin single nucleotide polymorphisms, calpastatin expression and tenderness in pork longissimus
    A K Lindholm-Perry
    USDA, ARS, U S Meat Animal Research Center, Clay Center, NE 68933 0166, USA
    Anim Genet 40:713-21. 2009
    Genome scans in the pig have identified a region on chromosome 2 (SSC2) associated with tenderness...
  98. doi QTL for traits related to humoral immune response estimated from data of a porcine F2 resource population
    K Wimmers
    Research Institute for the Biology of Farm Animals FBN, Research Unit Molecular Biology, Dummerstorf, Germany
    Int J Immunogenet 36:141-51. 2009
    ..05 and 0.01 level, respectively. The proximal region of SSC2 (orthologous to HSA11 0-70 Mb), the distal region of SSC4 (HSA1 95-155 Mb), and the intermediate region of SSC16 (..
  99. doi A genome-wide scan for quantitative trait loci affecting serum glucose and lipids in a White Duroc x Erhualian intercross F(2) population
    Rongrong Chen
    Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China, Jiangxi Agricultural University, Nanchang, China
    Mamm Genome 20:386-92. 2009
    ..QTL were identified for LDL-C, TC, and triglycerides (TG) in an adjacent region (67-73 cM) on chromosome 2 (SSC2), and the QTL for LDL-C showed the largest effect with a 95% confidence interval of 5 cM...
  100. doi Development of a high-density assay for long-chain fatty acyl-CoA elongases
    Hidefumi Kitazawa
    Department of Metabolic Disorder Research, Tsukuba Research Institute, Banyu Pharmaceutical Co, Ltd, Okubo 3, Tsukuba, Ibaraki, Japan
    Lipids 44:765-73. 2009
    ..As previously reported, ELOVL1, -3 and -6 preferably elongated the saturated fatty acyl-CoAs while ELOVL2 and ELOVL5 preferentially elongated the polyunsaturated fatty acyl-CoAs...
  101. doi Expression of long-chain polyunsaturated fatty acid (LC-PUFA) biosynthesis genes during zebrafish Danio rerio early embryogenesis
    Oscar Monroig
    Institute of Aquaculture, University of Stirling, Stirling FK9 4LA, Scotland, UK
    Biochim Biophys Acta 1791:1093-101. 2009
    ..of genes encoding enzymes involved in LC-PUFA biosynthesis, namely fatty acyl desaturase (Fad) and Elovl5- and Elovl2-like elongases, during early embryonic development of zebrafish...