ELOVL2

Summary

Gene Symbol: ELOVL2
Description: ELOVL fatty acid elongase 2
Alias: SSC2, elongation of very long chain fatty acids protein 2, 3-keto acyl-CoA synthase ELOVL2, ELOVL FA elongase 2, elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2, very long chain 3-ketoacyl-CoA synthase 2, very long chain 3-oxoacyl-CoA synthase 2
Species: human
Products:     ELOVL2

Top Publications

  1. Leonard A, Pereira S, Sprecher H, Huang Y. Elongation of long-chain fatty acids. Prog Lipid Res. 2004;43:36-54 pubmed
  2. Jakobsson A, Westerberg R, Jacobsson A. Fatty acid elongases in mammals: their regulation and roles in metabolism. Prog Lipid Res. 2006;45:237-49 pubmed
    ..monounsaturated VLCFA (ELOVL1, 3 and 6) and (b) enzymes which are elongases of polyunsaturated fatty acids (PUFA) (ELOVL2, 4 and 5). All the elongases exhibit specific spatial and temporal expression...
  3. Illig T, Gieger C, Zhai G, Römisch Margl W, Wang Sattler R, Prehn C, et al. A genome-wide perspective of genetic variation in human metabolism. Nat Genet. 2010;42:137-41 pubmed publisher
    ..For eight out of nine replicated loci (FADS1, ELOVL2, ACADS, ACADM, ACADL, SPTLC3, ETFDH and SLC16A9), the genetic variant is located in or near genes encoding enzymes ..
  4. Pauter A, Trattner S, Gonzalez Bengtsson A, Talamonti E, Asadi A, Dethlefsen O, et al. Both maternal and offspring Elovl2 genotypes determine systemic DHA levels in perinatal mice. J Lipid Res. 2017;58:111-123 pubmed publisher
    ..In order to address the question regarding the origin of DHA during perinatal life, we have used DHA-deficient Elovl2-ablated mice as a model system to analyze the maternal impact on the DHA level in their offspring of various ..
  5. Santiago Valtierra F, Peñalva D, Luquez J, Furland N, Vásquez C, Reyes J, et al. Elovl4 and Fa2h expression during rat spermatogenesis: a link to the very-long-chain PUFAs typical of germ cell sphingolipids. J Lipid Res. 2018;59:1175-1189 pubmed publisher
    ..Along with Elovl5 and Elovl2, Elovl4 was actively transcribed in the adult testis...
  6. Qiao R, Gao J, Zhang Z, Li L, Xie X, Fan Y, et al. Genome-wide association analyses reveal significant loci and strong candidate genes for growth and fatness traits in two pig populations. Genet Sel Evol. 2015;47:17 pubmed publisher
    ..On SSC2, a locus that significantly affects fatness traits mapped to the region around the IGF2 (insulin-like growth factor ..
  7. Björkgren I, Gylling H, Turunen H, Huhtaniemi I, Strauss L, Poutanen M, et al. Imbalanced lipid homeostasis in the conditional Dicer1 knockout mouse epididymis causes instability of the sperm membrane. FASEB J. 2015;29:433-42 pubmed publisher
    ..This study thus shows that Dicer1 is critical for lipid synthesis in the epididymis, which directly affects sperm membrane integrity and male fertility. ..
  8. Ferraz R, Kabeya N, Lopes Marques M, Machado A, Ribeiro R, Salaro A, et al. A complete enzymatic capacity for long-chain polyunsaturated fatty acid biosynthesis is present in the Amazonian teleost tambaqui, Colossoma macropomum. Comp Biochem Physiol B Biochem Mol Biol. 2018;227:90-97 pubmed publisher
    ..and functionally characterizing genes encoding key desaturase and elongase enzymes, namely fads2, elovl5 and elovl2, involved in the LC-PUFA biosynthetic pathways in tambaqui...
  9. Machado A, Tørresen O, Kabeya N, Couto A, Petersen B, Felício M, et al. "Out of the Can": A Draft Genome Assembly, Liver Transcriptome, and Nutrigenomics of the European Sardine, Sardina pilchardus. Genes (Basel). 2018;9: pubmed publisher
    ..To deliver a proof of principle of the value of this dataset, we established the presence and function of enzymes (Elovl2, Elovl5, and Fads2) that have pivotal roles in the biosynthesis of long chain polyunsaturated fatty acids, ..

More Information

Publications89

  1. Jung S, Lim S, Hong S, Lee E, Shin K, Lee H. DNA methylation of the ELOVL2, FHL2, KLF14, C1orf132/MIR29B2C, and TRIM59 genes for age prediction from blood, saliva, and buccal swab samples. Forensic Sci Int Genet. 2018;38:1-8 pubmed publisher
    ..In this study, DNA methylation at 5 CpG sites from the ELOVL2, FHL2, KLF14, C1orf132/MIR29B2C, and TRIM59 genes were investigated in 448 samples from blood, saliva, and buccal ..
  2. Trenhaile M, Petersen J, Kachman S, Johnson R, Ciobanu D. Long-term selection for litter size in swine results in shifts in allelic frequency in regions involved in reproductive processes. Anim Genet. 2016;47:534-42 pubmed publisher
    ..One of these regions, located on SSC2 (13-14 Mb), includes the candidate gene P2X3R, which plays a role in implantation and sustained release of ..
  3. Rönn T, Volkov P, Gillberg L, Kokosar M, Perfilyev A, Jacobsen A, et al. Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood. Hum Mol Genet. 2015;24:3792-813 pubmed publisher
    ..g. FHL2, NOX4 and PLG). Interestingly, many reported epigenetic biomarkers of aging in blood, including ELOVL2, FHL2, KLF14 and GLRA1, also showed significant correlations between adipose tissue DNA methylation and age in our ..
  4. Gregory M, James M. Rainbow trout (Oncorhynchus mykiss) Elov15 and Elov12 differ in selectivity for elongation of omega-3 docosapentaenoic acid. Biochim Biophys Acta. 2014;1841:1656-60 pubmed
    ..first to identify an Elov12 in rainbow trout (Oncorhynchus mykiss) and functionally chafacterise the Elovl5 and Elovl2 using a yeast expression system. Elovl5 was active with C18-20 PUFA substrates and not C22 PUFA...
  5. Hoile S, Clarke Harris R, Huang R, Calder P, Mori T, Beilin L, et al. Supplementation with N-3 long-chain polyunsaturated fatty acids or olive oil in men and women with renal disease induces differential changes in the DNA methylation of FADS2 and ELOVL5 in peripheral blood mononuclear cells. PLoS ONE. 2014;9:e109896 pubmed publisher
    ..FADS1 or ELOVL2 methylation was unchanged...
  6. Robichaud P, Munganyiki J, Boilard E, Surette M. Polyunsaturated fatty acid elongation and desaturation in activated human T cells: ELOVL5 is the key elongase. J Lipid Res. 2018;: pubmed publisher
    ..No quantifiable ELOVL2 was measured...
  7. Naue J, Sänger T, Hoefsloot H, Lutz Bonengel S, Kloosterman A, Verschure P. Proof of concept study of age-dependent DNA methylation markers across different tissues by massive parallel sequencing. Forensic Sci Int Genet. 2018;36:152-159 pubmed publisher
    ..whether 13 previously selected age-dependent loci based on whole blood analysis including amongst others ELOVL2, TRIM59, F5, and KLF14 also have predictive value in other forensically relevant tissues...
  8. Lemaitre R, Tanaka T, Tang W, Manichaikul A, Foy M, Kabagambe E, et al. Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. PLoS Genet. 2011;7:e1002193 pubmed publisher
    ..Minor alleles of SNPs in ELOVL2 (elongase) were associated with higher EPA (p?=?2 x 10?¹²) and DPA (p?=?1 x 10??³) and lower docosahexaenoic ..
  9. Sun C, Zou M, Wang X, Xia W, Ma Y, Liang S, et al. FADS1-FADS2 and ELOVL2 gene polymorphisms in susceptibility to autism spectrum disorders in Chinese children. BMC Psychiatry. 2018;18:283 pubmed publisher
    ..Sixteen tag single nucleotide polymorphisms from the FADS1-2 and ELOVL2 genes were genotyped using the Sequenom Mass Array...
  10. Cruciani Guglielmacci C, Bellini L, Denom J, Oshima M, Fernandez N, Normandie Levi P, et al. Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion. Mol Metab. 2017;6:340-351 pubmed publisher
    ..One of the predicted network hub genes was Elovl2, encoding Elongase of very long chain fatty acids 2...
  11. Slieker R, Relton C, Gaunt T, Slagboom P, Heijmans B. Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception. Epigenetics Chromatin. 2018;11:25 pubmed publisher
    ..Our analysis shows that age-related DNA methylation changes are highly tissue-specific. These results may guide the development of improved tissue-specific markers of chronological and, perhaps, biological age. ..
  12. Kananen L, Marttila S, Nevalainen T, Jylhävä J, Mononen N, Kähönen M, et al. Aging-associated DNA methylation changes in middle-aged individuals: the Young Finns study. BMC Genomics. 2016;17:103 pubmed publisher
    ..Repeatedly reported a-CpGs located in genes ELOVL2, FHL2, PENK and KLF14 were also identified...
  13. Xue X, Hixson S, Hori T, Booman M, Parrish C, Anderson D, et al. Atlantic salmon (Salmo salar) liver transcriptome response to diets containing Camelina sativa products. Comp Biochem Physiol Part D Genomics Proteomics. 2015;14:1-15 pubmed publisher
    ..btg1, dnph1, lect-2, clra, klf9, and fadsd6a], and three additional genes involved in lipid metabolism [elovl2, elovl5 (2 paralogues), and fadsd5], were subjected to QPCR with liver templates from all 5 dietary treatments...
  14. He Y, Ma J, Zhang F, Hou L, Chen H, Guo Y, et al. Multi-breed genome-wide association study reveals heterogeneous loci associated with loin eye area in pigs. J Appl Genet. 2016;57:511-518 pubmed
    ..area were identified, 11 of which surpassed the genome-wide significant threshold; of the 11 SNPs, seven located on SSC2 in F2 pigs and four located on SSC12 and SSC18 in Laiwu pigs...
  15. Ito H, Udono T, Hirata S, Inoue Murayama M. Estimation of chimpanzee age based on DNA methylation. Sci Rep. 2018;8:9998 pubmed publisher
    ..In the present study, a chimpanzee (Pan troglodytes) age prediction model was developed based on the ELOVL2, CCDC102B, and ZNF423 genes that may also have application in human age prediction...
  16. Cormier H, Rudkowska I, Lemieux S, Couture P, Julien P, Vohl M. Effects of FADS and ELOVL polymorphisms on indexes of desaturase and elongase activities: results from a pre-post fish oil supplementation. Genes Nutr. 2014;9:437 pubmed publisher
    ..Twenty-eight SNPs from FADS1, FADS2, FADS3, ELOVL2 and ELOVL5 were genotyped using TaqMan technology...
  17. Bellini L, Campana M, Rouch C, Chacińska M, Bugliani M, Meneyrol K, et al. Protective role of the ELOVL2/docosahexaenoic acid axis in glucolipotoxicity-induced apoptosis in rodent beta cells and human islets. Diabetologia. 2018;: pubmed publisher
    ..We recently showed that Elovl2 expression in beta cells, which regulates synthesis of endogenous DHA, was associated with glucose tolerance and ..
  18. Hu Y, Li H, Lu L, Manichaikul A, Zhu J, Chen Y, et al. Genome-wide meta-analyses identify novel loci associated with n-3 and n-6 polyunsaturated fatty acid levels in Chinese and European-ancestry populations. Hum Mol Genet. 2016;25:1215-24 pubmed publisher
    ..003). We also confirmed previously reported loci including FADS1, NTAN1, NRBF2, ELOVL2 and GCKR. Different effect sizes in FADS1 and independent association signals in ELOVL2 were observed...
  19. Gurgul A, Opiela J, Pawlina K, Szmatoła T, Bochenek M, Bugno Poniewierska M. The effect of histone deacetylase inhibitor trichostatin A on porcine mesenchymal stem cell transcriptome. Biochimie. 2017;139:56-73 pubmed publisher
    ..transcription, affecting genes across the whole genome with some minor signs of site-specific acting in regions on SSC2 and SSC6...
  20. Hamano Y, Manabe S, Morimoto C, Fujimoto S, Ozeki M, Tamaki K. Forensic age prediction for dead or living samples by use of methylation-sensitive high resolution melting. Leg Med (Tokyo). 2016;21:5-10 pubmed publisher
    ..In this study, a wide range methylation status in the ELOVL2 and FHL2 promoter regions were detected with methylation-sensitive high resolution melting (MS-HRM) in a labor-, ..
  21. Jin M, Monroig O, Navarro J, Tocher D, Zhou Q. Molecular and functional characterisation of two elovl4 elongases involved in the biosynthesis of very long-chain (>C24) polyunsaturated fatty acids in black seabream Acanthopagrus schlegelii. Comp Biochem Physiol B Biochem Mol Biol. 2017;212:41-50 pubmed publisher
    ..Moreover, knowledge of Elovl4 and other elongases such as Elovl2 has contributed to an advanced understanding of the LC-PUFA biosynthetic pathway in marine fish...
  22. Smith C, Follis J, Nettleton J, Foy M, Wu J, Ma Y, et al. Dietary fatty acids modulate associations between genetic variants and circulating fatty acids in plasma and erythrocyte membranes: Meta-analysis of nine studies in the CHARGE consortium. Mol Nutr Food Res. 2015;59:1373-83 pubmed publisher
    ..decarboxylase domain-containing 1), rs780094 in GCKR (glucokinase regulatory protein), and rs3734398 in ELOVL2 (fatty acid elongase 2))...
  23. Hao X, Plastow G, Zhang C, Xu S, Hu Z, Yang T, et al. Genome-wide association study identifies candidate genes for piglet splay leg syndrome in different populations. BMC Genet. 2017;18:64 pubmed publisher
    ..Seven chromosome-wide significant SNPs were identified on Sus scrofa chromosome 1 (SSC1), SSC2 (2 SNPs), SSC7, SSC15 (2 SNPs) and SSC16 after strict Bonferroni correction...
  24. Lago L, Nery da Silva A, Zanella E, Groke Marques M, Peixoto J, da Silva M, et al. Identification of Genetic Regions Associated with Scrotal Hernias in a Commercial Swine Herd. Vet Sci. 2018;5: pubmed publisher
    ..Using the ROH, we have identified an association (p = 0.019) on chromosome 2(SSC2) being segregated on animals with the presence of scrotal hernias...
  25. Spiers H, Hannon E, Wells S, Williams B, Fernandes C, Mill J. Age-associated changes in DNA methylation across multiple tissues in an inbred mouse model. Mech Ageing Dev. 2016;154:20-3 pubmed publisher
    ..We selected four high-confidence aDMPs (located in the vicinity of the ELOVL2, GLRA1, MYOD1 and PDE4C genes) and quantified DNA methylation across these regions in four tissues (blood, lung, ..
  26. Li D, Ji Y, Wang F, Wang M, Zhang C, Zhang W, et al. Regulation of crucial lncRNAs in differentiation of chicken embryonic stem cells to spermatogonia stem cells. Anim Genet. 2017;48:191-204 pubmed publisher
    ..Based on wego and string analyses, we found lnc-SSC1, lnc-SSC5, lnc-SSC2 and lnc-ESC2 negatively regulated target genes SUFU, EPHA3, KLF3, ARL3 and TRIM8, whereas SHH, NOTCH, TGF-?, cAMP/..
  27. Guo J, Ito S, Nguyen H, Yamamoto K, Tanoue R, Kunisue T, et al. Effects of prenatal exposure to triclosan on the liver transcriptome in chicken embryos. Toxicol Appl Pharmacol. 2018;347:23-32 pubmed publisher
    ..In females, TCS may further activate the lipogenesis signaling (e.g. ACSL5, ELOVL2) and repress the lipolysis signaling (e.g. ABHD5, ACAT2)...
  28. Taniguchi I, Iwaya C, Ohnaka K, Shibata H, Yamamoto K. Genome-wide DNA methylation analysis reveals hypomethylation in the low-CpG promoter regions in lymphoblastoid cell lines. Hum Genomics. 2017;11:8 pubmed publisher
    ..it was shown that the correlation between the chronological age and ageing-associated methylation sites in ELOVL2 and FHL2 in the LCLs was weaker than that in the PBCs...
  29. Horas H Nababan S, Nishiumi S, Kawano Y, Kobayashi T, Yoshida M, Azuma T. Adrenic acid as an inflammation enhancer in non-alcoholic fatty liver disease. Arch Biochem Biophys. 2017;623-624:64-75 pubmed publisher
    ..05). The accumulated adrenic acid in the CDAHFD-fed db/db mice was associated with increased expression of ELOVL2 and 5, and the suppression of the acyl-CoA oxidase 1 gene during peroxisomal β-oxidation...
  30. Talamonti E, Pauter A, Asadi A, Fischer A, Chiurchiù V, Jacobsson A. Impairment of systemic DHA synthesis affects macrophage plasticity and polarization: implications for DHA supplementation during inflammation. Cell Mol Life Sci. 2017;74:2815-2826 pubmed publisher
    ..status and inflammatory response of bone marrow-derived M1 and M2 macrophages obtained from mice deficient of Elovl2 (Elovl2-/-), a key enzyme for DHA synthesis in mammals...
  31. Tan P, Chang C, Duan K, Poidinger M, Ng K, Chong Y, et al. E2F1 Orchestrates Transcriptomics and Oxidative Metabolism in Wharton's Jelly-Derived Mesenchymal Stem Cells from Growth-Restricted Infants. PLoS ONE. 2016;11:e0163035 pubmed publisher
    ..One of the key genes regulated by E2F1 was found to be the fatty acid elongase ELOVL2, a gene involved in the endogenous synthesis of docosahexaenoic acid (DHA)...
  32. Zbieć Piekarska R, Spólnicka M, Kupiec T, Parys Proszek A, Makowska Å, PaÅ‚eczka A, et al. Development of a forensically useful age prediction method based on DNA methylation analysis. Forensic Sci Int Genet. 2015;17:173-179 pubmed publisher
    ..The five most significantly correlated CpG sites in ELOVL2 on 6p24.2, C1orf132 on 1q32.2, TRIM59 on 3q25.33, KLF14 on 7q32.3 and FHL2 on 2q12...
  33. He Y, Li X, Zhang F, Su Y, Hou L, Chen H, et al. Multi-breed genome-wide association study reveals novel loci associated with the weight of internal organs. Genet Sel Evol. 2015;47:87 pubmed publisher
    ..In addition, two QTL were detected in several populations, including one on SSC2 for heart weight in the F2 and Sutai populations and one on SSC7 for liver weight in the F2 and Laiwu populations...
  34. Cho S, Jung S, Hong S, Lee E, Lee J, Lee S, et al. Independent validation of DNA-based approaches for age prediction in blood. Forensic Sci Int Genet. 2017;29:250-256 pubmed publisher
    ..current study, signal-joint T-cell receptor excision circles (sjTRECs) and DNA methylation markers located in the ELOVL2, C1orf132, TRIM59, KLF14, and FHL2 genes were reanalyzed in 100 Korean blood samples to test their associations ..
  35. Bovo S, Schiavo G, Mazzoni G, Dall Olio S, Galimberti G, Calò D, et al. Genome-wide association study for the level of serum electrolytes in Italian Large White pigs. Anim Genet. 2016;47:597-602 pubmed publisher
    ..Only one SNP (on SSC7) and six SNPs (on SSC2 and SSC7) showed moderate association with the level of magnesium and phosphorus respectively...
  36. Hidalgo A, Lopes M, Harlizius B, Bastiaansen J. Genome-wide association study reveals regions associated with gestation length in two pig populations. Anim Genet. 2016;47:223-6 pubmed publisher
    ..For LW, four associated SNPs were detected in one region of 0.14 Mbp on SSC5. The region on SSC2 contains the heparin-binding EGF-like growth factor (HBEGF) gene, which promotes embryo implantation and has been ..
  37. Kabeya N, Yamamoto Y, Cummins S, Elizur A, Yazawa R, Takeuchi Y, et al. Polyunsaturated fatty acid metabolism in a marine teleost, Nibe croaker Nibea mitsukurii: Functional characterization of Fads2 desaturase and Elovl5 and Elovl4 elongases. Comp Biochem Physiol B Biochem Mol Biol. 2015;188:37-45 pubmed publisher
    ..produced transgenic Nibe croaker (Nibea mitsukurii) carrying an elongase of very-long-chain fatty acids 2 (elovl2) gene isolated from Masu salmon (Oncorhynchus masou)...
  38. Monroig Ã, Lopes Marques M, Navarro J, Hontoria F, Ruivo R, Santos M, et al. Evolutionary functional elaboration of the Elovl2/5 gene family in chordates. Sci Rep. 2016;6:20510 pubmed publisher
    ..Here we examine key components of the LC-PUFA cascade, the Elovl2/Elovl5 elongases, from amphioxus, an invertebrate chordate, the sea lamprey, a representative of agnathans, and ..
  39. Guo Y, Huang Y, Hou L, Ma J, Chen C, Ai H, et al. Genome-wide detection of genetic markers associated with growth and fatness in four pig populations using four approaches. Genet Sel Evol. 2017;49:21 pubmed publisher
    ..associated with the nine traits, including four genome-wide significant single nucleotide polymorphisms (SNPs) on SSC2 (SSC for Sus scrofa chromosome), 4, 7 and X...
  40. Wang P, Huo H, Wang S, Miao Y, Zhang Y, Zhang Q, et al. Cloning, sequence characterization, and expression patterns of members of the porcine TSSK family. Genet Mol Res. 2015;14:14908-19 pubmed publisher
    ..on the Sus scrofa chromosome (SSC) 14, and consist of a single exon; TSSK3, TSSK4, and TSSK6 are on SSC6, SSC7, and SSC2, and consist of two, four, and one exon, respectively...
  41. Yan M, Qi H, Li J, Ye G, Shao Y, Li T, et al. Identification of SPOP related metabolic pathways in prostate cancer. Oncotarget. 2017;8:103032-103046 pubmed publisher
    ..Furthermore, both correlation analyses based on integrated data and cBioportal revealed that FH, ELOVL2 and ACADL genes might be involved in SPOP-mutation-related upregulation of these metabolic ..
  42. Kone M, Pullen T, Sun G, Ibberson M, Martinez Sanchez A, Sayers S, et al. LKB1 and AMPK differentially regulate pancreatic β-cell identity. FASEB J. 2014;28:4972-85 pubmed publisher
    ..Loss of LKB1 strikingly (2.0-12-fold, E<0.01) increased the expression of subsets of hepatic (Alb, Iyd, Elovl2) and neuronal (Nptx2, Dlgap2, Cartpt, Pdyn) genes, enhancing glutamate signaling...
  43. Morales E, Bustamante M, Gonzalez J, Guxens M, Torrent M, Mendez M, et al. Genetic variants of the FADS gene cluster and ELOVL gene family, colostrums LC-PUFA levels, breastfeeding, and child cognition. PLoS ONE. 2011;6:e17181 pubmed publisher
    ..Tag SNPs were genotyped both in mothers and children (13 in the FADS cluster, 6 in ELOVL2, and 7 in ELOVL5)...
  44. Zhou X, Wan D, Zhang Y, Zhang Y, Long C, Chen S, et al. Diurnal variations in polyunsaturated fatty acid contents and expression of genes involved in their de novo synthesis in pigs. Biochem Biophys Res Commun. 2017;483:430-434 pubmed publisher
    ..in mRNA expression of FASD1 (Delta 5-desaturase), FASD2 (Delta 6-desaturase), ELOVL5 (fatty acid elongase 5) and ELOVL2 in liver, with an unexpectedly high level at night...
  45. Guo Y, Hou L, Zhang X, Huang M, Mao H, Chen H, et al. A meta analysis of genome-wide association studies for limb bone lengths in four pig populations. BMC Genet. 2015;16:95 pubmed publisher
    ..several loci showed specific effect on the length of one limb bone, such as the locus at the proximal end of SSC2 associated with only the scapula length...
  46. Mansego M, Milagro F, Zulet M, Moreno Aliaga M, Martínez J. Differential DNA Methylation in Relation to Age and Health Risks of Obesity. Int J Mol Sci. 2015;16:16816-32 pubmed publisher
    ..In addition, DNA methylation of three CpG sites located in ELOVL2; HOXC4 and PI4KB were further negatively associated with their mRNA levels...
  47. Dai W, Panserat S, Kaushik S, Terrier F, Plagnes Juan E, Seiliez I, et al. Hepatic fatty acid biosynthesis is more responsive to protein than carbohydrate in rainbow trout during acute stimulations. Am J Physiol Regul Integr Comp Physiol. 2016;310:R74-86 pubmed publisher
    ..and ATP citrate lyase (ACLY)], lipid bioconversion [elongation of very long chain fatty acids like-5 (Elovl5), Elovl2, Δ6 fatty acyl desaturase (D6D) and stearoyl-CoA desaturase-1 (SCD1)], NADPH production [glucose-6-phosphate ..
  48. Irvine N, Lillycrop K, Fielding B, Torrens C, Hanson M, Burdge G. Polyunsaturated fatty acid biosynthesis is involved in phenylephrine-mediated calcium release in vascular smooth muscle cells. Prostaglandins Leukot Essent Fatty Acids. 2015;101:31-9 pubmed publisher
    ..6 (D6d) and Δ5 (D5d) desaturase, and elongase (Elovl) 5 were expressed. Elovl2 was not detected in human, mouse or rat VSM cells, or in rat or mouse aortae, but tit was not associated with ..
  49. Zhao G, Gao J, Liang S, Wang X, Sun C, Xia W, et al. Study of the serum levels of polyunsaturated fatty acids and the expression of related liver metabolic enzymes in a rat valproate-induced autism model. Int J Dev Neurosci. 2015;44:14-21 pubmed publisher
    ..the expression of related liver metabolic enzymes, including Δ5-desaturase, Δ6-desaturase and elongase (Elovl2), in VPA-exposed and control rats on postnatal day 35 (PND35) and conducted sex dimorphic analysis...
  50. Wijesena H, Lents C, Riethoven J, Trenhaile Grannemann M, Thorson J, Keel B, et al. GENOMICS SYMPOSIUM: Using genomic approaches to uncover sources of variation in age at puberty and reproductive longevity in sows. J Anim Sci. 2017;95:4196-4205 pubmed publisher
    ..7% of the genetic variation of age at puberty. One of the high-ranked windows detected (SSC2, 12-12.9 Mb) showed pleiotropic features, affecting both age at puberty and litter size traits...
  51. Song Z, Cao H, Qin L, Jiang Y. A case-control study between gene polymorphisms of polyunsaturated fatty acid metabolic rate-limiting enzymes and acute coronary syndrome in Chinese Han population. Biomed Res Int. 2013;2013:928178 pubmed publisher
    ..acid desaturase 1 (FADS1), fatty acid desaturase 2 (FADS2), and elongation of very long-chain fatty acids-like 2 (ELOVL2) and acute coronary syndrome (ACS) in Chinese Han population...
  52. Leonard A, Bobik E, Dorado J, Kroeger P, Chuang L, Thurmond J, et al. Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids. Biochem J. 2000;350 Pt 3:765-70 pubmed
    ..Furthermore, the HELO1 gene is located on chromosome 6, best known for encoding the major histocompatibility complex, which is essential to the human immune response. ..
  53. Gopalan S, Carja O, Fagny M, Patin E, Myrick J, McEwen L, et al. Trends in DNA Methylation with Age Replicate Across Diverse Human Populations. Genetics. 2017;206:1659-1674 pubmed publisher
    ..We confirmed that an age-associated site in the promoter of the gene ELOVL2 shows a remarkably congruent relationship with aging in humans, despite extensive genetic and environmental ..
  54. De Paoli Iseppi R, Polanowski A, McMahon C, Deagle B, Dickinson J, Hindell M, et al. DNA methylation levels in candidate genes associated with chronological age in mammals are not conserved in a long-lived seabird. PLoS ONE. 2017;12:e0189181 pubmed publisher
    ..325, p = 0.019). In feather samples ELOVL2 (CpG42: R2 = 0.285, p = 0.00048) and EDARADD (CpG46: R2 = 0.168, p = 0.0067) were also weakly correlated with age...
  55. Warzych E, Pawlak P, Pszczola M, Cieslak A, Lechniak D. Prepubertal heifers versus cows-The differences in the follicular environment. Theriogenology. 2017;87:36-47 pubmed publisher
    ..LDs) number in oocytes, expression of seven genes involved in energy metabolism (fatty acids [FAs] metabolism-ELOVL2, ELOVL5, SCD, FADS2, glucose transport-GLUT1, GLUT3, GLUT8) in CC and GC as well as FA composition and glucose ..
  56. Fadhlaoui M, Pierron F, Couture P. Temperature and metal exposure affect membrane fatty acid composition and transcription of desaturases and elongases in fathead minnow muscle and brain. Ecotoxicol Environ Saf. 2018;148:632-643 pubmed publisher
    ..To this end, muscle and brain membrane FA composition and FA desaturase (fads2, degs2 and scd2) and elongase (elovl2, elovl5 and elovl6) gene transcription levels were analyzed in fathead minnows (Pimephales promelas) acclimated ..
  57. Gonzalez Bengtsson A, Asadi A, Gao H, Dahlman Wright K, Jacobsson A. Estrogen Enhances the Expression of the Polyunsaturated Fatty Acid Elongase Elovl2 via ER? in Breast Cancer Cells. PLoS ONE. 2016;11:e0164241 pubmed publisher
    ..We demonstrate a robust up-regulation in the expression of the fatty acid elongases Elovl2 and Elovl5 upon estradiol stimulation in MCF7 cells, which was sustained for more than 24 hours...
  58. Wu P, Yang Q, Wang K, Zhou J, Ma J, Tang Q, et al. Single step genome-wide association studies based on genotyping by sequence data reveals novel loci for the litter traits of domestic pigs. Genomics. 2018;110:171-179 pubmed publisher
    ..SSC14: 16314857), 4 (SSC1: 81986236, SSC1: 66599775, SSC1: 161999013, and SSC1: 267883107), and 5 (SSC9: 29030061, SSC2: 32368561, SSC5: 110375350, SSC13: 45619882 and SSC13: 45647829) significant SNPs for TNB, NBA, and LWB were ..
  59. Hamano Y, Manabe S, Morimoto C, Fujimoto S, Tamaki K. Forensic age prediction for saliva samples using methylation-sensitive high resolution melting: exploratory application for cigarette butts. Sci Rep. 2017;7:10444 pubmed publisher
    ..The methylation profiles of ELOVL2 and EDARADD showed high correlations with age and were used to predict age with support vector regression...
  60. Chiurchiù V, Leuti A, Dalli J, Jacobsson A, Battistini L, Maccarrone M, et al. Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses. Sci Transl Med. 2016;8:353ra111 pubmed publisher
    ..These results were also supported in vivo in a mouse deficient for DHA synthesis (Elovl2(-/-)) that showed an increase in TH1/TH17 cells and a decrease in Treg cells compared to wild-type mice...
  61. Li M, Zhai S, Xie Q, Tian L, Li X, Zhang J, et al. Effects of Dietary n-6:n-3 PUFA Ratios on Lipid Levels and Fatty Acid Profile of Cherry Valley Ducks at 15-42 Days of Age. J Agric Food Chem. 2017;65:9995-10002 pubmed publisher
    ..The hepatic expression of FADS2, ELOVL5, FADS1, and ELOVL2 increased on a quadratic function with decreasing dietary n-6:n-3 PUFA ratios...
  62. Kobayashi T, Zadravec D, Jacobsson A. ELOVL2 overexpression enhances triacylglycerol synthesis in 3T3-L1 and F442A cells. FEBS Lett. 2007;581:3157-63 pubmed
    Elongation of very long-chain fatty acids (ELOVL) members were overexpressed in two preadipocyte cell lines, ELOVL2 and ELOVL3 in 3T3-L1 cells, and ELOVL1-3 in F442A cells...
  63. Zhang J, Qin X, Liang A, Kim E, Lawrence P, Park W, et al. Fads3 modulates docosahexaenoic acid in liver and brain. Prostaglandins Leukot Essent Fatty Acids. 2017;123:25-32 pubmed publisher
    ..Fads2 mRNA levels were significantly downregulated whereas expression levels of elongation of very long chain 2 (Elovl2) and Elovl5 genes were upregulated compared to age-matched WT...
  64. Spolnicka M, Pospiech E, Pepłońska B, Zbieć Piekarska R, Makowska Z, Pieta A, et al. DNA methylation in ELOVL2 and C1orf132 correctly predicted chronological age of individuals from three disease groups. Int J Legal Med. 2018;132:1-11 pubmed publisher
    ..We analyzed DNA methylation profile in five markers from five different genes (ELOVL2, C1orf132, KLF14, FHL2, and TRIM59) used for forensic age prediction in three groups of individuals with diagnosed ..
  65. Tanaka T, Shen J, Abecasis G, Kisialiou A, Ordovas J, Guralnik J, et al. Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study. PLoS Genet. 2009;5:e1000338 pubmed publisher
    ..region of association mapped to chromosome 6 in the region encoding an elongase of very long fatty acids 2 (ELOVL2). In this region, association was observed with EPA (rs953413; p = 1.1 x 10(-6))...
  66. Warzych E, Pawlak P, Pszczola M, Cieslak A, Madeja Z, Lechniak D. Interactions of bovine oocytes with follicular elements with respect to lipid metabolism. Anim Sci J. 2017;88:1491-1497 pubmed publisher
    ..number in oocytes (BODIPY staining), mRNA expression of seven genes in cumulus and granulosa cells (SCD, FADS2, ELOVL2, ELOVL5, GLUT1, GLUT3, GLUT8; real time polymerase chain reaction) and fatty acid (FA) composition in FF (gas ..
  67. Xia D, Sun L, Shi J, Yu Y, Xie L. [A case-control study between gene polymorphisms of polyunsaturated fatty acids metabolic rate-limiting enzymes and paranoid schizophrenia of Han ethnicity in Jilin Province]. Wei Sheng Yan Jiu. 2011;40:154-7 pubmed
    ..association between gene polymorphisms of FADS 1 (fatty acid desaturase 1) , FADS2 (fatty acid desaturase 2) and ELOVL2 (elongation of very long chain fatty acids (FEN1/ Elo2, SUR4/Elo3, yeast) -like 2) and paranoid schizophrenia of ..
  68. Garagnani P, Bacalini M, Pirazzini C, Gori D, Giuliani C, Mari D, et al. Methylation of ELOVL2 gene as a new epigenetic marker of age. Aging Cell. 2012;11:1132-4 pubmed publisher
    ..whole blood DNA from a small cohort of 64 subjects of different ages, we identified 3 regions, the CpG islands of ELOVL2, FHL2, and PENK genes, whose methylation level strongly correlates with age...
  69. Naue J, Hoefsloot H, Mook O, Rijlaarsdam Hoekstra L, van der Zwalm M, Henneman P, et al. Chronological age prediction based on DNA methylation: Massive parallel sequencing and random forest regression. Forensic Sci Int Genet. 2017;31:19-28 pubmed publisher
    ..based on publicly available 450K microarray data, and 13 finally selected for the age tool based on MPS (DDO, ELOVL2, F5, GRM2, HOXC4, KLF14, LDB2, MEIS1-AS3, NKIRAS2, RPA2, SAMD10, TRIM59, ZYG11A)...
  70. Bacalini M, Deelen J, Pirazzini C, De Cecco M, Giuliani C, Lanzarini C, et al. Systemic Age-Associated DNA Hypermethylation of ELOVL2 Gene: In Vivo and In Vitro Evidences of a Cell Replication Process. J Gerontol A Biol Sci Med Sci. 2017;72:1015-1023 pubmed publisher
    ..We recently demonstrated that DNA methylation of ELOVL2 and FHL2 CpG islands is highly correlated with age in whole blood...
  71. Barman M, Nilsson S, Torinsson Naluai Ã, Sandin A, Wold A, Sandberg A. Single Nucleotide Polymorphisms in the FADS Gene Cluster but not the ELOVL2 Gene are Associated with Serum Polyunsaturated Fatty Acid Composition and Development of Allergy (in a Swedish Birth Cohort). Nutrients. 2015;7:10100-15 pubmed publisher
    ..In 211 subjects, we investigated whether polymorphisms in the FADS gene cluster and the ELOVL2 gene were associated with allergy or PUFA composition in serum phospholipids in a Swedish birth-cohort sampled at ..
  72. Zbieć Piekarska R, Spólnicka M, Kupiec T, Makowska Å, Spas A, Parys Proszek A, et al. Examination of DNA methylation status of the ELOVL2 marker may be useful for human age prediction in forensic science. Forensic Sci Int Genet. 2015;14:161-7 pubmed publisher
    ..this study, we optimized an assay based on bisulfite conversion and pyrosequencing of 7 CpG sites located in the ELOVL2 gene...
  73. Qin L, Sun L, Ye L, Shi J, Zhou L, Yang J, et al. A case-control study between the gene polymorphisms of polyunsaturated fatty acids metabolic rate-limiting enzymes and coronary artery disease in a Chinese Han population. Prostaglandins Leukot Essent Fatty Acids. 2011;85:329-33 pubmed publisher
    ..acid desaturase 1 (FADS1), fatty acid desaturase 2 (FADS2) and elongation of very long chain fatty acids like 2 (ELOVL2) gene and coronary artery disease (CAD) in a Chinese Han population...
  74. Leonard A, Kelder B, Bobik E, Chuang L, Lewis C, Kopchick J, et al. Identification and expression of mammalian long-chain PUFA elongation enzymes. Lipids. 2002;37:733-40 pubmed
    ..4 and 58% identity, respectively, to that of ELOVL5. The open reading frame of the human clone (ELOVL2) encodes a 296-amino acid peptide, whereas the mouse clone (Elovl2) encodes a 292-amino acid peptide...
  75. Ohno Y, Suto S, Yamanaka M, Mizutani Y, Mitsutake S, Igarashi Y, et al. ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis. Proc Natl Acad Sci U S A. 2010;107:18439-44 pubmed publisher
    ..Finally, knockdown of ELOVL1 caused a reduction in the activity of the Src kinase LYN, confirming that C24-sphingolipids are particularly important in membrane microdomain function. ..
  76. Freire Aradas A, Phillips C, Mosquera Miguel A, Girón Santamaría L, Gomez Tato A, Casares de Cal M, et al. Development of a methylation marker set for forensic age estimation using analysis of public methylation data and the Agena Bioscience EpiTYPER system. Forensic Sci Int Genet. 2016;24:65-74 pubmed publisher
    ..based on a multivariate quantile regression analysis was built using the seven highest age-correlated loci of ELOVL2, ASPA, PDE4C, FHL2, CCDC102B, C1orf132 and chr16:85395429...
  77. Schiavo G, Hoffmann O, Ribani A, Utzeri V, Ghionda M, Bertolini F, et al. A genomic landscape of mitochondrial DNA insertions in the pig nuclear genome provides evolutionary signatures of interspecies admixture. DNA Res. 2017;24:487-498 pubmed publisher
    ..99) to the chromosome length. The longest numt sequence (about 11 kbp) was located on SSC2. Six numts were sequenced and PCR amplified in pigs of European commercial and local pig breeds, of the Chinese ..
  78. Anzai Á, Marcondes R, Gonçalves T, Carvalho K, Simões M, Garcia N, et al. Impaired branched-chain amino acid metabolism may underlie the nonalcoholic fatty liver disease-like pathology of neonatal testosterone-treated female rats. Sci Rep. 2017;7:13167 pubmed publisher
    ..Testos group also had a decreased liver fatty acid elongase 2 (ELOVL2) activity. E2 group had reduced lipid and acylcarnitine metabolites in the liver...
  79. Li X, Gan Z, Ding Z, Wu Y, Chen X, Tian H, et al. Genetic Variants in the ELOVL5 but not ELOVL2 Gene Associated with Polyunsaturated Fatty Acids in Han Chinese Breast Milk. Biomed Environ Sci. 2017;30:64-67 pubmed publisher
    ..2% for eicosapentaenoic acid (EPA) to 6.0% for LA. Our findings demonstrated that common variation in ELOVL5 gene encoding rate-limiting enzymes in the metabolism of PUFAs contribute to the PUFAs in breast milk. ..
  80. Roy S, Chakraborty H, Kumar V, Behera B, Rana R, Babu G. In Silico Structural Studies and Molecular Docking Analysis of Delta6-desaturase in HUFA Biosynthetic Pathway. Anim Biotechnol. 2017;:1-13 pubmed publisher
    ..Protein association analysis showed a high confidence score with acyl-CoA synthetase, elovl5, elovl2, and phospholipase A2...