ELL

Summary

Gene Symbol: ELL
Description: elongation factor for RNA polymerase II
Alias: C19orf17, ELL1, MEN, PPP1R68, RNA polymerase II elongation factor ELL, ELL gene (11-19 lysine-rich leukemia gene), eleven-nineteen lysine-rich leukemia protein, elongation factor RNA polymerase II, protein phosphatase 1, regulatory subunit 68
Species: human
Products:     ELL

Top Publications

  1. Luo R, Lavau C, Du C, Simone F, Polak P, Kawamata S, et al. The elongation domain of ELL is dispensable but its ELL-associated factor 1 interaction domain is essential for MLL-ELL-induced leukemogenesis. Mol Cell Biol. 2001;21:5678-87 pubmed
    The MLL-ELL chimeric gene is the product of the (11;19)(q23p13.1) translocation associated with de novo and therapy-related acute myeloid leukemias (AML)...
  2. Yokoyama A, Lin M, Naresh A, Kitabayashi I, Cleary M. A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription. Cancer Cell. 2010;17:198-212 pubmed publisher
    ..Thus, AEP recruitment is an integral part of both physiological and pathological MLL-dependent transcriptional pathways. Bypass of its normal recruitment mechanisms is the strategy most frequently used by MLL oncoproteins. ..
  3. Sobhian B, Laguette N, Yatim A, Nakamura M, Levy Y, Kiernan R, et al. HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP. Mol Cell. 2010;38:439-51 pubmed publisher
    ..Tatcom1 consists of the core active P-TEFb, MLL-fusion partners involved in leukemia (AF9, AFF4, AFF1, ENL, and ELL), and PAF1 complex...
  4. Thirman M, Levitan D, Kobayashi H, Simon M, Rowley J. Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia. Proc Natl Acad Sci U S A. 1994;91:12110-4 pubmed
    ..We have named this gene ELL (for eleven-nineteen lysine-rich leukemia gene)...
  5. Shilatifard A, Lane W, Jackson K, Conaway R, Conaway J. An RNA polymerase II elongation factor encoded by the human ELL gene. Science. 1996;271:1873-6 pubmed
    The human ELL gene on chromosome 19 undergoes frequent translocations with the trithorax-like MLL gene on chromosome 11 in acute myeloid leukemias...
  6. Polak P, Simone F, Kaberlein J, Luo R, Thirman M. ELL and EAF1 are Cajal body components that are disrupted in MLL-ELL leukemia. Mol Biol Cell. 2003;14:1517-28 pubmed
    The (11;19)(q23;p13.1) translocation in acute leukemia results in the formation of a chimeric MLL-ELL fusion protein...
  7. Hu B, Zhang W, Feng X, Ji W, Xie X, Xiao W. Zebrafish eaf1 suppresses foxo3b expression to modulate transcriptional activity of gata1 and spi1 in primitive hematopoiesis. Dev Biol. 2014;388:81-93 pubmed publisher
    Studies implicate a potential role for EAF1 in MLL-ELL induced leukemogenesis; however the biological function of EAF1 in this process remains unknown...
  8. Acuña P, Li Z, Santiago Calvo M, Villafañe F, Rodriguez Perez M, Wang D. Influence of the Characteristics of Expandable Graphite on the Morphology, Thermal Properties, Fire Behaviour and Compression Performance of a Rigid Polyurethane Foam. Polymers (Basel). 2019;11: pubmed publisher
    ..We find that ell size distributions were less homogeneous and cell size was reduced...
  9. Burmeister T, Molkentin M, Meyer C, Lachmann N, Schwartz S, Friedrichs B, et al. Molecular monitoring of minimal residual disease in two patients with MLL-rearranged acute myeloid leukemia and haploidentical transplantation after relapse. Exp Hematol Oncol. 2012;1:6 pubmed publisher
    ..2;q23) with MLL-AF10 and the second a t(11;19)(q23;p13.1) with MLL-ELL fusion...

More Information

Publications116 found, 100 shown here

  1. Carew N, Nelson A, Liang Z, Smith S, Milcarek C. Linking Endoplasmic Reticular Stress and Alternative Splicing. Int J Mol Sci. 2018;19: pubmed publisher
    ..ELL2 is necessary for immunoglobulin secretion and does this by changing mRNA processing patterns of immunoglobulin heavy chain and >5000 other genes. ..
  2. Zhu T, Zeng W, Chen Y, Zhang Y, Sun J, Liang Z, et al. 2D/3D CMR tissue tracking versus CMR tagging in the assessment of spontaneous T2DM rhesus monkeys with isolated diastolic dysfunction. BMC Med Imaging. 2018;18:47 pubmed publisher
    ..Circumferential and longitudinal peak systolic strain (Ecc, Ell), time to peak strain (tEcc, tEll) and peak diastolic strain rate (CSR, LSR) obtained from 2D/3D CMR-TT were ..
  3. Zhu R, Lu X, Pradhan M, Armstrong S, Storchan G, Chow C, et al. A kinase-independent activity of Cdk9 modulates glucocorticoid receptor-mediated gene induction. Biochemistry. 2014;53:1753-67 pubmed publisher
    ..We therefore asked if cofactors (Cdk9 and ELL) best known to affect paused polymerase could reverse the effects of NELF-A and -B...
  4. Khan J, Singh A, Nazir S, Kanagala P, Gershlick A, McCann G. Comparison of cardiovascular magnetic resonance feature tracking and tagging for the assessment of left ventricular systolic strain in acute myocardial infarction. Eur J Radiol. 2015;84:840-8 pubmed publisher
    ..5T was performed in 24 patients, 2.2 days post STEMI. Global and segmental circumferential (Ecc) and longitudinal (Ell) strain were assessed using FT and tagging, and correlated with total and segmental infarct size, area at risk and ..
  5. Voltersen V, Blango M, Herrmann S, Schmidt F, Heinekamp T, Strassburger M, et al. Proteome Analysis Reveals the Conidial Surface Protein CcpA Essential for Virulence of the Pathogenic Fungus Aspergillus fumigatus. MBio. 2018;9: pubmed publisher
    ..One protein, designated conidial cell wall protein A (CcpA), was identified by both methods and was found to be nearly as abundant as ..
  6. Kishi S, Gidding S, Reis J, Colangelo L, Venkatesh B, Armstrong A, et al. Association of Insulin Resistance and Glycemic Metabolic Abnormalities With LV Structure and Function in Middle Age: The CARDIA Study. JACC Cardiovasc Imaging. 2017;10:105-114 pubmed publisher
    ..LV mass, relative wall thickness, LV ejection fraction (LVEF), longitudinal systolic strain (Ell), and early diastolic strain rate (Ell_SRe) at year 25 were assessed by echocardiography...
  7. Chung C, Berson A, Kennerdell J, Sartoris A, Unger T, Porta S, et al. Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity. Nat Commun. 2018;9:4406 pubmed publisher
    ..Here we identify the transcriptional elongation factor Ell-a shared component of little elongation complex (LEC) and super elongation complex (SEC)-as a strong modifier of ..
  8. Park K, Bayles I, Szlachta McGinn A, Paul J, Boiko J, Santos P, et al. Transcription elongation factor ELL2 drives Ig secretory-specific mRNA production and the unfolded protein response. J Immunol. 2014;193:4663-74 pubmed publisher
    ..Transcription yields from the cyclin B2 and the canonical UPR promoter elements are upregulated by ELL2 cDNA. Thus, ELL2 is important for many aspects of Ab secretion, XBP1 expression, and the UPR. ..
  9. Mileva G, Kozak I, Lewis J. Short-term synaptic plasticity across topographic maps in the electrosensory system. Neuroscience. 2016;318:1-11 pubmed publisher
    ..of tuberous electroreceptors distributed over the skin provides inputs to the electrosensory lateral line lobe (ELL), forming the basis for three topographic maps: LS (lateral segment), CLS (centrolateral segment), and CMS (..
  10. Wehner G, Jing L, Haggerty C, Suever J, Chen J, Hamlet S, et al. Comparison of left ventricular strains and torsion derived from feature tracking and DENSE CMR. J Cardiovasc Magn Reson. 2018;20:63 pubmed publisher
    ..001, CoV: 41%), and overestimated dyssynchrony (bias: 26 ms, p < 0.001, CoV: 76%). Longitudinal strain (Ell) had borderline-acceptable agreement (bias: - 0.2%, p = 0.77, CoV: 19%)...
  11. Ohyama Y, Ambale Venkatesh B, Chamera E, Shehata M, Corona Villalobos C, Zimmerman S, et al. Comparison of strain measurement from multimodality tissue tracking with strain-encoding MRI and harmonic phase MRI in pulmonary hypertension. Int J Cardiol. 2015;182:342-348 pubmed publisher
    ..In 45 subjects (30 PH patients and 15 normal subjects), RV and LV peak global longitudinal strains (Ell) were measured from long axis 4 chamber view using MTT...
  12. Taylor R, Moody W, Umar F, Edwards N, Taylor T, Stegemann B, et al. Myocardial strain measurement with feature-tracking cardiovascular magnetic resonance: normal values. Eur Heart J Cardiovasc Imaging. 2015;16:871-81 pubmed publisher
    ..One hundred healthy individuals, with 10 men and women in each of 5 age deciles from 20 to 70 years, without a history of cardiovascular disease, diabetes, ..
  13. Qi S, Li Z, Schulze Gahmen U, Stjepanovic G, Zhou Q, Hurley J. Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription. Nat Commun. 2017;8:14076 pubmed publisher
    The intrinsically disordered scaffold proteins AFF1/4 and the transcription elongation factors ELL1/2 are core components of the super elongation complex required for HIV-1 proviral transcription. Here we report the 2...
  14. Liu B, Dardeer A, Moody W, Edwards N, Hudsmith L, Steeds R. Normal values for myocardial deformation within the right heart measured by feature-tracking cardiovascular magnetic resonance imaging. Int J Cardiol. 2018;252:220-223 pubmed publisher
    ..RV longitudinal strain (Ell) was -21.9±3.24% (FW+S Ell) and -24.2±3.59% (FW-Ell). Peak systolic strain rate (S') was -1.45±0...
  15. Chandrasekaran M, Chandrasekar R, Chun S, Sathiyabama M. Isolation, characterization and molecular three-dimensional structural predictions of metalloprotease from a phytopathogenic fungus, Alternaria solani (Ell. and Mart.) Sor. J Biosci Bioeng. 2016;122:131-9 pubmed publisher
    ..Thus, it can be concluded that the major proteinases of AsK are divalent cation-requiring metalloproteinases and make them potential targets of protease inhibitors designing. ..
  16. Knutson B, Smith M, Walker Kopp N, Xu X. Super elongation complex contains a TFIIF-related subcomplex. Transcription. 2016;7:133-40 pubmed publisher
    ..We show that the SEC subunit ELL interacts with the Pol II Rbp2 subunit, as expected for a TFIIF-like factor...
  17. Larson E, Metzen M, Chacron M. Serotonin modulates electrosensory processing and behavior via 5-HT2-like receptors. Neuroscience. 2014;271:108-18 pubmed publisher
    ..weakly electric fish is to enhance sensory pyramidal neuron responses within the electrosensory lateral line lobe (ELL) to stimuli caused by same sex conspecifics, thereby enhancing their perception...
  18. Requarth T, Kaifosh P, Sawtell N. A role for mixed corollary discharge and proprioceptive signals in predicting the sensory consequences of movements. J Neurosci. 2014;34:16103-16 pubmed publisher
    ..Here we use an advantageous model system--the electrosensory lobe (ELL) of weakly electric mormyrid fish--to directly examine how CD and proprioceptive feedback signals are transformed ..
  19. Jiang Y, Fu R, Zhao J, Wu D, Qiao G, Li R, et al. Effects of ELL-associated factor 2 on ultraviolet radiation-induced cataract formation in mice. Mol Med Rep. 2015;12:6605-11 pubmed publisher
    b>ELL-associated factor 2 (Eaf2) has an important role in crystalline lens development and maturation; however, its role in ultraviolet radiation (UV)-induced cataract formation has remained elusive...
  20. Takahashi H, Takigawa I, Watanabe M, Anwar D, Shibata M, Tomomori Sato C, et al. MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex. Nat Commun. 2015;6:5941 pubmed publisher
    ..Recently, the little elongation complex (LEC)-which contains the transcription elongation factor ELL/EAF-was found to be required for the transcription of Pol II-dependent small nuclear RNA (snRNA) genes...
  21. Conger D. Foreign-born Peers and Academic Performance. Demography. 2015;52:569-92 pubmed publisher
    ..distinction between the effects of sharing schools with immigrants who are designated as English language learners (ELL) and those who are not...
  22. Marcoux C, Clarke S, Nesse W, Longtin A, Maler L. Balanced ionotropic receptor dynamics support signal estimation via voltage-dependent membrane noise. J Neurophysiol. 2016;115:530-45 pubmed publisher
    ..this permits stimulus-evoked changes in EA spiking to be transmitted efficiently to target electrosensory lobe (ELL) pyramidal cells, for encoding low-frequency signals...
  23. Wang H, Bei L, Shah C, Huang W, Platanias L, Eklund E. The E3 ubiquitin ligase Triad1 influences development of Mll-Ell-induced acute myeloid leukemia. Oncogene. 2018;37:2532-2544 pubmed publisher
    ..In the current study, we investigate the role of Triad1 in leukemogenesis induced by an MLL1 fusion protein (Mll-Ell)...
  24. Cao J, Ngai N, Duncanson L, Cheng J, Gliganic K, Chen Q. A comparison of both DENSE and feature tracking techniques with tagging for the cardiovascular magnetic resonance assessment of myocardial strain. J Cardiovasc Magn Reson. 2018;20:26 pubmed publisher
    ..the comparisons of peak circumferential (Ecc) and radial strain (Err) and a 4-chamber view for longitudinal strain (Ell)...
  25. Burmeister T, Meyer C, Gröger D, Hofmann J, Marschalek R. Evidence-based RT-PCR methods for the detection of the 8 most common MLL aberrations in acute leukemias. Leuk Res. 2015;39:242-7 pubmed publisher
    ..for the reliable detection of the 8 most common MLL aberrations (MLL-AF4, MLL-AF6, MLL-AF9, MLL-AF10, MLL-ENL, MLL-ELL, MLL-EPS15, MLL PTD), together accounting for around 90% of MLL-r cases...
  26. Greseth M, Carter D, Terhune S, Traktman P. Proteomic Screen for Cellular Targets of the Vaccinia Virus F10 Protein Kinase Reveals that Phosphorylation of mDia Regulates Stress Fiber Formation. Mol Cell Proteomics. 2017;16:S124-S143 pubmed publisher
    ..and induced cells, we performed stable isotope labeling of amino acids in cell culture (SILAC) coupled with phosphopeptide analysis to identify cellular targets of F10-mediated phosphorylation...
  27. Kawczyk Krupka A, Czuba Z, Kwiatek B, Kwiatek S, Krupka M, Sieron K. The effect of ALA-PDT under normoxia and cobalt chloride (CoCl2)-induced hypoxia on adhesion molecules (ICAM-1, VCAM-1) secretion by colorectal cancer cells. Photodiagnosis Photodyn Ther. 2017;19:103-115 pubmed publisher
    ..The secretion of ICAM-1 by SW480 ell line was more pronounced compared to ICAM-1 secretion by SW620 cells...
  28. Prodromidou A, Machairas N, Spartalis E, Kostakis I, Iavazzo C, Moris D, et al. Transperitoneal Versus Extraperitoneal Laparoscopic Lymphadenectomy for Gynecological Malignancies: A Systematic Review and Meta-analysis. Anticancer Res. 2018;38:4677-4681 pubmed publisher
    ..Our meta-analysis accumulated the current evidence on the impact of transperitoneal (TLL) and extraperitoneal (ELL) laparoscopic lymphadenectomy for the management of patients with gynecological malignancies...
  29. Jung S, Longtin A, Maler L. Weak signal amplification and detection by higher-order sensory neurons. J Neurophysiol. 2016;115:2158-75 pubmed publisher
    ..processing areas, namely, the electroreceptor afferents (EAs) and pyramidal cells (PCs) of the electrosensory lobe (ELL), the first-order electrosensory processing area...
  30. Guo W, Keener A, Jing Y, Cai L, Ai J, Zhang J, et al. FOXA1 modulates EAF2 regulation of AR transcriptional activity, cell proliferation, and migration in prostate cancer cells. Prostate. 2015;75:976-87 pubmed publisher
    b>ELL-associated factor 2 (EAF2) is an androgen-regulated tumor suppressor in the prostate. However, the mechanisms underlying tumor suppressive function of EAF2 are still largely unknown...
  31. Tanabe S, Kawabata T, Aoyagi K, Yokozaki H, Sasaki H. Gene expression and pathway analysis of CTNNB1 in cancer and stem cells. World J Stem Cells. 2016;8:384-395 pubmed
    ..receptor A8 (EPHA8), synovial sarcoma translocation chromosome 18 (SS18), interactor of little elongation complex ELL subunit 1 (ICE1), patched 1 (PTCH1), mutS homolog 3 (MSH3) and caspase recruitment domain family member 11 (CARD11) ..
  32. Jorritsma R, van Geijlswijk I, Nielen M. Randomized prospective trials to study effects of reduced antibiotic usage in abdominal surgery in cows. J Dairy Sci. 2018;101:8217-8223 pubmed publisher
    ..v. (ell)...
  33. Egloff S, Vitali P, Tellier M, Raffel R, Murphy S, Kiss T. The 7SK snRNP associates with the little elongation complex to promote snRNA gene expression. EMBO J. 2017;36:934-948 pubmed publisher
    ..as a canonical transcription factor that, in collaboration with the little elongation complex (LEC) comprising ELL, Ice1, Ice2, and ZC3H8, promotes transcription of RNAPII-specific spliceosomal snRNA and small nucleolar RNA (..
  34. Zhou Y, Fan W, Deng J, Xi H. Establishment and analysis of the prediction model for cervical squamous cell carcinoma. Eur Rev Med Pharmacol Sci. 2017;21:5042-5048 pubmed publisher
    ..05). The model fitting effect was good, Cox-Sn ell R2 was 0.643 and Nagelkerke R2 was 0.958. The high accuracy of the model was 98.5%...
  35. Feng K, Guo H. Eaf2 protects human lens epithelial cells against oxidative stress?induced apoptosis by Wnt signaling. Mol Med Rep. 2018;17:2795-2802 pubmed publisher
    The tumor suppressor protein ELL-associated factor 2 (Eaf2) serves an important role in lens development and maturation; however, its role in oxidative stress?induced cataract formation remains unclear...
  36. Witten A, Bolbrinker J, Barysenka A, Huber M, Rühle F, Nowak Gottl U, et al. Targeted resequencing of a locus for heparin-induced thrombocytopenia on chromosome 5 identified in a genome-wide association study. J Mol Med (Berl). 2018;96:765-775 pubmed publisher
    ..5 × 10-2). For the genes interactor of little elongation complex ELL subunit 1 (ICE1) and a disintegrin-like and metalloproteinase with thrombospondin type 1 motif, 16 (ADAMTS16) ..
  37. Nawaz Z, Kakar K, Saand M, Shu Q. Cyclic nucleotide-gated ion channel gene family in rice, identification, characterization and experimental analysis of expression response to plant hormones, biotic and abiotic stresses. BMC Genomics. 2014;15:853 pubmed publisher
    ..We successively built a stringent motif: (LI-X(2)-[GS]-X-[FV]-X-G-[1]-ELL-X-W-X(12,22)-SA-X(2)-T-X(7)-[EQ]-AF-X-L) that recognizes the rice CNGCs specifically...
  38. Ge L, Wu Y, Soleimani M, Khazalpour M, Takaba K, Tartibi M, et al. Moderate Ischemic Mitral Regurgitation After Posterolateral Myocardial Infarction in Sheep Alters Left Ventricular Shear but Not Normal Strain in the Infarct and Infarct Borderzone. Ann Thorac Surg. 2016;101:1691-9 pubmed publisher
    ..Three-dimensional strain was calculated. Circumferential strain (Ecc) and longitudinal strain (Ell) were reduced in the infarct proper, MI borderzone, and remote myocardium 16 weeks after MI...
  39. Mashruwala A, Gries C, Scherr T, Kielian T, Boyd J. SaeRS Is Responsive to Cellular Respiratory Status and Regulates Fermentative Biofilm Formation in Staphylococcus aureus. Infect Immun. 2017;85: pubmed publisher
    ..We recently reported that impaired respiration elicits a programmed cell lysis (PCL) phenomenon in S...
  40. Deemyad T, Maler L, Chacron M. Inhibition of SK and M channel-mediated currents by 5-HT enables parallel processing by bursts and isolated spikes. J Neurophysiol. 2011;105:1276-94 pubmed publisher
    ..We investigated these effects in pyramidal neurons within the electrosensory lateral line lobe (ELL) of weakly electric fish...
  41. Morais P, Marchi A, Bogaert J, Dresselaers T, Heyde B, D hooge J, et al. Cardiovascular magnetic resonance myocardial feature tracking using a non-rigid, elastic image registration algorithm: assessment of variability in a real-life clinical setting. J Cardiovasc Magn Reson. 2017;19:24 pubmed publisher
    ..EccSAX and ErrSAX, respectively) and longitudinal strain in the long-axis direction (EllLAX). The level of CMR experience of the observers was 2 weeks, 6 months and >20 years...
  42. Shah C, Bei L, Wang H, Altman J, Platanias L, Eklund E. Cooperation between AlphavBeta3 integrin and the fibroblast growth factor receptor enhances proliferation of Hox-overexpressing acute myeloid leukemia cells. Oncotarget. 2016;7:54782-54794 pubmed publisher
    ..FGF2 (Fibroblast Growth Factor 2) as a target gene for HoxA9 and HoxA10 that was indirectly activated by Mll-Ell (an Mll1-fusion protein)...
  43. Groves J, Maduka A, O Meally R, Cole R, Zachara N. Fatty acid synthase inhibits the O-GlcNAcase during oxidative stress. J Biol Chem. 2017;292:6493-6511 pubmed publisher
    ..biotinylation in combination with stable isotopic labeling of amino acids in cell culture (SILAC)...
  44. Paulrayer A, Adithan A, Lee J, Moon K, Kim D, Im S, et al. Aronia melanocarpa (Black Chokeberry) Reduces Ethanol-Induced Gastric Damage via Regulation of HSP-70, NF-κB, and MCP-1 Signaling. Int J Mol Sci. 2017;18: pubmed publisher
    i>Aronia melanocarpa (Michx.) Ell. belongs to the Rosaceae family...
  45. Uemura S, Tamura A, Saito A, Hasegawa D, Nino N, Yokoi T, et al. Reemergence of translocation t(11;19)(q23;p13.1) in the absence of clinically overt leukemia. Int J Hematol. 2017;106:847-851 pubmed publisher
    ..1) MLL-ELL variant, in which intron 8 of MLL is fused to exon 6 of ELL...
  46. Li Y, Takahashi Y, Fujii S, Zhou Y, Hong R, Suzuki A, et al. EAF2 mediates germinal centre B-cell apoptosis to suppress excessive immune responses and prevent autoimmunity. Nat Commun. 2016;7:10836 pubmed publisher
    Regulated apoptosis of germinal centre (GC) B cells is critical for normal humoral immune responses. ELL-associated factor 2 (EAF2) regulates transcription elongation and has been shown to be an androgen-responsive potential tumour ..
  47. Makarova O, Adams D, Divan R, Rosenmann D, Zhu P, Li S, et al. Polymer microfilters with nanostructured surfaces for the culture of circulating cancer cells. Mater Sci Eng C Mater Biol Appl. 2016;66:193-198 pubmed publisher
    ..Our data suggest that RIE modified polymer filters can isolate model cell lines while retaining ell viability, and that the RIE filter modification allows T24 monolayering cells to proliferate as a structured ..
  48. Ai J, Pascal L, Wei L, Zang Y, Zhou Y, Yu X, et al. EAF2 regulates DNA repair through Ku70/Ku80 in the prostate. Oncogene. 2017;36:2054-2065 pubmed publisher
    ..Recent studies showed regulation of DNA repair genes by androgen receptor signaling in prostate cancers. ELL-associated factor 2 (EAF2) is an androgen-regulated tumor suppressor and its intracellular localization can be ..
  49. Liu X, Chen Z, Ouyang G, Song T, Liang H, Liu W, et al. ELL Protein-associated Factor 2 (EAF2) Inhibits Transforming Growth Factor β Signaling through a Direct Interaction with Smad3. J Biol Chem. 2015;290:25933-45 pubmed publisher
    ..Furthermore, we demonstrated that EAF2 suppresses both TGF-β-induced G1 cell cycle arrest and TGF-β-induced cell migration. This study identifies and characterizes a novel repressor of TGF-β signaling. ..
  50. Zang Y, Dong Y, Yang D, Xue B, Li F, Gu P, et al. Expression and prognostic significance of ELL-associated factor 2 in human prostate cancer. Int Urol Nephrol. 2016;48:695-700 pubmed publisher
    b>ELL-associated factor 2 (EAF2) is an androgen-regulated tumor suppressor in the prostate...
  51. O Connor D, Smith R, Piras B, Beyers R, Lin D, Hossack J, et al. Heart Rate Reduction With Ivabradine Protects Against Left Ventricular Remodeling by Attenuating Infarct Expansion and Preserving Remote-Zone Contractile Function and Synchrony in a Mouse Model of Reperfused Myocardial Infarction. J Am Heart Assoc. 2016;5: pubmed publisher
    ..Speckle-tracking software was used to calculate intramural longitudinal myocardial strain (Ell) and strain rate...
  52. Helie S, Turner B, Crossley M, Ell S, Ashby F. Trial-by-trial identification of categorization strategy using iterative decision-bound modeling. Behav Res Methods. 2017;49:1146-1162 pubmed publisher
    ..The new method is then used to reanalyze data from Ell and Ashby (2006)...
  53. Qiu X, Pascal L, Song Q, Zang Y, Ai J, O Malley K, et al. Physical and Functional Interactions between ELL2 and RB in the Suppression of Prostate Cancer Cell Proliferation, Migration, and Invasion. Neoplasia. 2017;19:207-215 pubmed publisher
    Elongation factor, RNA polymerase II, 2 (ELL2) is expressed and regulated by androgens in the prostate. ELL2 and ELL-associated factor 2 (EAF2) form a stable complex, and their orthologs in Caenorhabditis elegans appear to be ..
  54. Gibasiewicz K, Białek R, Pajzderska M, Karolczak J, Burdziński G, Jones M, et al. Weak temperature dependence of P (+) H A (-) recombination in mutant Rhodobacter sphaeroides reaction centers. Photosynth Res. 2016;128:243-58 pubmed publisher
    ..In the case of a mutant which displays rapid P (+) H A (-) recombination (ELL), most of this recombination occurs in an unrelaxed protein in which P (+) B A (-) and P (+) H A (-) are almost ..
  55. Webber J, Raichlen D. The role of plantigrady and heel-strike in the mechanics and energetics of human walking with implications for the evolution of the human foot. J Exp Biol. 2016;219:3729-3737 pubmed
    ..during walking), impact transient (rapid increase in ground force at touchdown) and effective limb length (ELL) in subjects (n=14) who walked at self-selected speeds using HS and NHS gaits...
  56. Artiaco S, Fusini F, Colzani G, Massè A, Battiston B. Chronic Essex-Lopresti injury: a systematic review of current treatment options. Int Orthop. 2018;: pubmed publisher
    Essex-Lopresti lesion (ELL) is a severe injury. Most of ELL is recognized in chronic phase representing a therapeutic challenge for orthopaedic surgeons...
  57. Kobayashi S, Obata M, Hagihara M, Motohashi K, Ito S, Ohshima R, et al. The presence of mature granulocytes/monocytes derived from leukemic cells in MLL-associated leukemia. Int J Hematol. 2009;90:591-596 pubmed publisher
    ..MLL partner genes were AF6, AF9, ELL, and ENL, respectively...
  58. Benjamin A, Korkmaz F, Elsasser T, Kerr D. Neonatal lipopolysaccharide exposure does not diminish the innate immune response to a subsequent lipopolysaccharide challenge in Holstein bull calves. J Dairy Sci. 2016;99:5750-5763 pubmed publisher
    ..Ten Holstein bull calves were randomly assigned to either an early life LPS (ELL) group (n=5) or an early life saline (ELS) group (n=5)...
  59. Hollmann V, Engelmann J, Gómez Sena L. A quest for excitation: Theoretical arguments and immunohistochemical evidence of excitatory granular cells in the ELL of Gnathonemus petersii. J Physiol Paris. 2016;110:190-199 pubmed publisher
    The Electrosensory Lateral Line lobe (ELL) is the first central target where the electrosensory information encoded in the spatiotemporal pattern electroreceptor afferent discharges is processed...
  60. Anwar D, Takahashi H, Watanabe M, Suzuki M, Fukuda S, Hatakeyama S. p53 represses the transcription of snRNA genes by preventing the formation of little elongation complex. Biochim Biophys Acta. 2016;1859:975-82 pubmed publisher
    The regulation of transcription by RNA polymerase II (Pol II) is important for a variety of cellular functions. ELL/EAF-containing little elongation complex (LEC) was found to be required for transcription of Pol II-dependent small ..
  61. Bello M, Morales González J. Molecular recognition between potential natural inhibitors of the Keap1-Nrf2 complex. Int J Biol Macromol. 2017;105:981-992 pubmed publisher
    ..Gs): 3-O-a-L arabinofuranoside-7-O-a-l-rhamnopyranoside of kaempferol (KAM), gallic acid (GAL), ellagic acid (ELL) and geranium acetonitrile (ACE), which based on experimental findings have been proposed as possible Keap1-Nrf2 ..
  62. Roberts P. Modeling inhibitory plasticity in the electrosensory system of mormyrid electric fish. J Neurophysiol. 2000;84:2035-47 pubmed
    ..induced by plasticity at inhibitory synapses in a cerebellum-like structure, the electrosensory lateral line lobe (ELL) of mormyrid electric fish...
  63. Simone F, Polak P, Kaberlein J, Luo R, Levitan D, Thirman M. EAF1, a novel ELL-associated factor that is delocalized by expression of the MLL-ELL fusion protein. Blood. 2001;98:201-9 pubmed
    ..leukemia leads to the generation of a chimeric protein that fuses MLL to the transcriptional elongation factor ELL. A novel protein was isolated from a yeast 2-hybrid screen with ELL that was named EAF1 for ELL-associated factor 1...
  64. Monroe S, Jo S, Sanders D, Basrur V, Elenitoba Johnson K, Slany R, et al. MLL-AF9 and MLL-ENL alter the dynamic association of transcriptional regulators with genes critical for leukemia. Exp Hematol. 2011;39:77-86.e1-5 pubmed publisher
    ..C-terminal domain of AF9 associates with many other MLL translocation partners including Enl, Af4, Laf4, Af5q31, Ell, and Af10...
  65. Pascal L, Masoodi K, Liu J, Qiu X, Song Q, Wang Y, et al. Conditional deletion of ELL2 induces murine prostate intraepithelial neoplasia. J Endocrinol. 2017;235:123-136 pubmed publisher
    ..factor, RNA polymerase II, 2 (ELL2) is an RNA Pol II elongation factor with functional properties similar to ELL that can interact with the prostate tumor suppressor EAF2...
  66. Wang Y, Pascal L, Zhong M, Ai J, Wang D, Jing Y, et al. Combined Loss of EAF2 and p53 Induces Prostate Carcinogenesis in Male Mice. Endocrinology. 2017;158:4189-4205 pubmed publisher
    ..b>ELL-associated factor 2 (EAF2) is a tumor suppressor that is frequently downregulated in advanced prostate cancer...
  67. Dabas P, Sweta K, Ekka M, Sharma N. Structure function characterization of the ELL Associated Factor (EAF) from Schizosaccharomyces pombe. Gene. 2018;641:117-128 pubmed publisher
    EAF (ELL Associated Factor) proteins interact with the transcription elongation factor, ELL (Eleven nineteen Lysine rich Leukemia) and enhance its ability to stimulate RNA polymerase II-mediated transcriptional elongation in vitro...
  68. Hutten S, Chachami G, Winter U, Melchior F, Lamond A. A role for the Cajal-body-associated SUMO isopeptidase USPL1 in snRNA transcription mediated by RNA polymerase II. J Cell Sci. 2014;127:1065-78 pubmed publisher
    ..Thus, our data indicate that USPL1 plays a key role in RNAPII-mediated snRNA transcription. ..
  69. Fufa T, Byun J, Wakano C, Fernandez A, Pise Masison C, Gardner K. The Tax oncogene enhances ELL incorporation into p300 and P-TEFb containing protein complexes to activate transcription. Biochem Biophys Res Commun. 2015;465:5-11 pubmed publisher
    The eleven-nineteen lysine-rich leukemia protein (ELL) is a key regulator of RNA polymerase II mediated transcription...
  70. Ngole Jeme V, Ekosse G, Songca S. An analysis of human exposure to trace elements from deliberate soil ingestion and associated health risks. J Expo Sci Environ Epidemiol. 2018;28:55-63 pubmed publisher
    ..Average daily intake values were lower than their respective reference doses for ell elements except for Pb in selected samples...
  71. Shilatifard A. Identification and purification of the Holo-ELL complex. Evidence for the presence of ELL-associated proteins that suppress the transcriptional inhibitory activity of ELL. J Biol Chem. 1998;273:11212-7 pubmed
    The human ELL gene on chromosome 19 undergoes frequent translocation with the trithorax-like MLL gene on chromosome 11 in acute myeloid leukemia...
  72. Jiang F, Ai J, Xiao W, Wang Z. FB1, an E2A fusion partner in childhood leukemia, interacts with U19/EAF2 and inhibits its transcriptional activity. Cancer Lett. 2007;253:265-72 pubmed
    ..U19/EAF2 has also been identified as ELL-associated factor 2 (EAF2) based on its binding to ELL, a fusion partner of MLL in acute myeloid leukemia...
  73. Byun J, Fufa T, Wakano C, Fernandez A, Haggerty C, Sung M, et al. ELL facilitates RNA polymerase II pause site entry and release. Nat Commun. 2012;3:633 pubmed publisher
    ..Recent advances have identified the super elongation complex, containing the eleven-nineteen lysine-rich leukaemia (ELL) protein, as a key regulator of transcriptional elongation...
  74. Karn J, Stoltzfus C. Transcriptional and posttranscriptional regulation of HIV-1 gene expression. Cold Spring Harb Perspect Med. 2012;2:a006916 pubmed publisher
    ..In cells that are not fully activated, limiting levels of Tat and Rev act as potent blocks to premature virus production. ..
  75. Nilson K, Price D. The Role of RNA Polymerase II Elongation Control in HIV-1 Gene Expression, Replication, and Latency. Genet Res Int. 2011;2011:726901 pubmed publisher
    ..HIV, the causative agent of AIDS, is a worldwide health concern. It is hoped that knowledge of the mechanisms regulating the expression of the HIV genome will lead to treatments and ultimately a cure. ..
  76. Chen Y, Zhou C, Ji W, Mei Z, Hu B, Zhang W, et al. ELL targets c-Myc for proteasomal degradation and suppresses tumour growth. Nat Commun. 2016;7:11057 pubmed publisher
    Increasing evidence supports that ELL (eleven-nineteen lysine-rich leukaemia) is a key regulator of transcriptional elongation, but the physiological function of Ell in mammals remains elusive...
  77. Alexander L, Watters J, Reusch J, Maurin M, Nepon Sixt B, Vrzalikova K, et al. Data supporting the functional role of Eleven-nineteen Lysine-rich Leukemia 3 (ELL3) in B cell lymphoma cell line cells. Data Brief. 2017;15:222-227 pubmed publisher
    ..of publicly available mRNA expression data from primary murine B cells to reveal dynamic regulation of the ELL family members post LPS stimulation (Barwick et al., 2016) [2]...
  78. Shinobu N, Maeda T, Aso T, Ito T, Kondo T, Koike K, et al. Physical interaction and functional antagonism between the RNA polymerase II elongation factor ELL and p53. J Biol Chem. 1999;274:17003-10 pubmed
    b>ELL was originally identified as a gene that undergoes translocation with the trithorax-like MLL gene in acute myeloid leukemia...
  79. Schmidt A, Miller T, Schmidt S, Shiekhattar R, Shilatifard A. Cloning and characterization of the EAP30 subunit of the ELL complex that confers derepression of transcription by RNA polymerase II. J Biol Chem. 1999;274:21981-5 pubmed
    The product of the human oncogene ELL encodes an RNA polymerase II transcription factor that undergoes frequent translocation in acute myeloid leukemia (AML)...
  80. Lewis J, Maler L. Dynamics of electrosensory feedback: short-term plasticity and inhibition in a parallel fiber pathway. J Neurophysiol. 2002;88:1695-706 pubmed
    ..and a disynaptic (feed-forward) inhibitory connection to pyramidal neurons in the electrosensory lateral line lobe (ELL)...
  81. Yamada K, Kawata H, Shou Z, Hirano S, Mizutani T, Yazawa T, et al. Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3. Biochem J. 2003;373:167-78 pubmed
  82. Kong S, Banks C, Shilatifard A, Conaway J, Conaway R. ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL. Proc Natl Acad Sci U S A. 2005;102:10094-8 pubmed
    In human cells, the ELL family of transcription factors includes at least three members, which are all capable of stimulating the overall rate of elongation by RNA polymerase II by suppressing transient pausing by the enzyme at many ..
  83. Mourgues S, Gautier V, Lagarou A, Bordier C, Mourcet A, Slingerland J, et al. ELL, a novel TFIIH partner, is involved in transcription restart after DNA repair. Proc Natl Acad Sci U S A. 2013;110:17927-32 pubmed publisher
    ..Using an unbiased proteomic approach, we have identified the protein eleven-nineteen lysine-rich leukemia (ELL) as a TFIIH partner...
  84. Simone F, Luo R, Polak P, Kaberlein J, Thirman M. ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with alternative ELL binding properties. Blood. 2003;101:2355-62 pubmed
    The (11;19)(q23;p13.1) translocation in acute leukemia results in the formation of an MLL-ELL fusion protein. ELL is an RNA polymerase II elongation factor that interacts with the recently identified EAF1 protein...
  85. Shi J, Fu Q, Yang P, Liu H, Ji L, Wang K. Downregulation of microRNA-15a-3p is correlated with clinical outcome and negatively regulates cancer proliferation and migration in human osteosarcoma. J Cell Biochem. 2018;119:1215-1222 pubmed publisher
    ..The functional regulations of miR-15a-3p overexpression on cancer ell proliferation and migration were then analyzed...
  86. Lapinskas T, Grune J, Zamani S, Jeuthe S, Messroghli D, Gebker R, et al. Cardiovascular magnetic resonance feature tracking in small animals - a preliminary study on reproducibility and sample size calculation. BMC Med Imaging. 2017;17:51 pubmed publisher
    ..Left ventricular (LV) longitudinal, circumferential and radial strain (EllLAX, EccSAX and ErrSAX) were calculated...
  87. Ownsworth T, Fleming J, Tate R, Beadle E, Griffin J, Kendall M, et al. Do People With Severe Traumatic Brain Injury Benefit From Making Errors? A Randomized Controlled Trial of Error-Based and Errorless Learning. Neurorehabil Neural Repair. 2017;31:1072-1082 pubmed publisher
    Errorless learning (ELL) and error-based learning (EBL) are commonly used approaches to rehabilitation for people with traumatic brain injury (TBI)...
  88. Doiron B, Longtin A, Turner R, Maler L. Model of gamma frequency burst discharge generated by conditional backpropagation. J Neurophysiol. 2001;86:1523-45 pubmed
    Pyramidal cells of the electrosensory lateral line lobe (ELL) of the weakly electric fish Apteronotus leptorhynchus have been shown to produce oscillatory burst discharge in the gamma-frequency range (20-80 Hz) in response to constant ..
  89. Yu X, Ai J, Cai L, Jing Y, Wang D, Dong J, et al. Regulation of tumor suppressor EAF2 polyubiquitination by ELL1 and SIAH2 in prostate cancer cells. Oncotarget. 2016;7:29245-54 pubmed publisher
    ..We previously reported that its binding partner ELL1 can enhance EAF2 protein stability and activity...
  90. Alexander L, Watters J, Reusch J, Maurin M, Nepon Sixt B, Vrzalikova K, et al. Selective expression of the transcription elongation factor ELL3 in B cells prior to ELL2 drives proliferation and survival. Mol Immunol. 2017;91:8-16 pubmed publisher
    ..We report that a SEC component, the Eleven -nineteen Lysine-rich leukemia (ELL) family member 3 (ELL3) is dynamically up-regulated in mature and activated human B cells followed by suppression ..
  91. Sweta K, Dabas P, Jain K, Sharma N. The amino-terminal domain of ELL transcription elongation factor is essential for ELL function in Schizosaccharomyces pombe. Microbiology. 2017;163:1641-1653 pubmed publisher
    ..to gain insights into the in vivo cellular functions of SpELL, we identified phenotypes associated with deletion of ell1 in S. pombe. Our results demonstrate that SpELL is required for normal growth of S. pombe cells...
  92. Iwabuchi K, Bartel P, Li B, Marraccino R, Fields S. Two cellular proteins that bind to wild-type but not mutant p53. Proc Natl Acad Sci U S A. 1994;91:6098-102 pubmed
    ..The characteristics of these interactions argue that 53BP1 and 53BP2 are involved in some aspect of p53-mediated tumor suppression. ..