EIF4G1

Summary

Gene Symbol: EIF4G1
Description: eukaryotic translation initiation factor 4 gamma 1
Alias: EIF-4G1, EIF4F, EIF4G, EIF4GI, P220, PARK18, eukaryotic translation initiation factor 4 gamma 1, EIF4-gamma, eIF-4-gamma 1, eucaryotic translation initiation factor 4G
Species: human
Products:     EIF4G1

Top Publications

  1. Yanagiya A, Svitkin Y, Shibata S, Mikami S, Imataka H, Sonenberg N. Requirement of RNA binding of mammalian eukaryotic translation initiation factor 4GI (eIF4GI) for efficient interaction of eIF4E with the mRNA cap. Mol Cell Biol. 2009;29:1661-9 pubmed publisher
    ..Here, we used recombinant proteins to reconstitute the cap binding of the mammalian eIF4E-eIF4GI complex to investigate the importance of the RNA-binding region of eIF4GI for cap interaction with eIF4E...
  2. Alvarez E, Menendez Arias L, Carrasco L. The eukaryotic translation initiation factor 4GI is cleaved by different retroviral proteases. J Virol. 2003;77:12392-400 pubmed
    ..In the present work, cleavage of both eIF4GI and eIF4GII has been analyzed by employing the proteases encoded within the genomes of several members of the ..
  3. Connolly E, Braunstein S, Formenti S, Schneider R. Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells. Mol Cell Biol. 2006;26:3955-65 pubmed
    ..Breast cancer cells therefore acquire resistance to hypoxia by uncoupling oxygen-responsive signaling pathways from mTOR function, eliminating inhibition of protein synthesis mediated by 4E-BP1 and eEF2. ..
  4. LeFebvre A, Korneeva N, Trutschl M, Cvek U, Duzan R, Bradley C, et al. Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit. J Biol Chem. 2006;281:22917-32 pubmed
    ..The role of mammalian eIF3 in assembly of the 48 S complex occurs through high affinity binding to eIF4G. Interactions of eIF4G with eIF4E, eIF4A, eIF3, poly(A)-binding protein, and Mnk1/2 have been mapped to discrete ..
  5. Ramírez Valle F, Braunstein S, Zavadil J, Formenti S, Schneider R. eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy. J Cell Biol. 2008;181:293-307 pubmed publisher
    ..We show that depletion of initiation factor eIF4GI only modestly reduces overall protein synthesis in cells, but phenocopies nutrient starvation or inhibition of ..
  6. Mader S, Lee H, Pause A, Sonenberg N. The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins. Mol Cell Biol. 1995;15:4990-7 pubmed
    ..These results shed light on the mechanisms of eIF-4F assembly and on the translational regulation by insulin and growth factors. ..
  7. Imataka H, Sonenberg N. Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A. Mol Cell Biol. 1997;17:6940-7 pubmed
    Mammalian translation initiation factor 4F (eIF4F) consists of three subunits, eIF4A, eIF4E, and eIF4G. eIF4G interacts directly with both eIF4A and eIF4E...
  8. Gradi A, Imataka H, Svitkin Y, Rom E, Raught B, Morino S, et al. A novel functional human eukaryotic translation initiation factor 4G. Mol Cell Biol. 1998;18:334-42 pubmed
    ..To date, however, only one functional eIF4G polypeptide, referred to here as eIF4GI, has been identified in mammals...
  9. Imataka H, Gradi A, Sonenberg N. A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation. EMBO J. 1998;17:7480-9 pubmed
    ..Using 5' rapid amplification of cDNA, we have extended the known human eIF4GI open reading frame from the N-terminus by 156 amino acids...

More Information

Publications88

  1. Kim K, Cho H, Choi K, Kim J, Kim B, Ko Y, et al. A new MIF4G domain-containing protein, CTIF, directs nuclear cap-binding protein CBP80/20-dependent translation. Genes Dev. 2009;23:2033-45 pubmed publisher
  2. Suzuki C, Garces R, Edmonds K, Hiller S, Hyberts S, Marintchev A, et al. PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains. Proc Natl Acad Sci U S A. 2008;105:3274-9 pubmed publisher
    ..We found that the PDCD4 MA3 domains compete with the eIF4G MA3 domain and RNA for eIF4A binding...
  3. Fabian M, Mathonnet G, Sundermeier T, Mathys H, Zipprich J, Svitkin Y, et al. Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation. Mol Cell. 2009;35:868-80 pubmed publisher
    ..Importantly, we present evidence that GW182, a core component of the miRISC, directly interacts with PABP via its C-terminal region and that this interaction is required for miRNA-mediated deadenylation...
  4. Rufener S, Mühlemann O. eIF4E-bound mRNPs are substrates for nonsense-mediated mRNA decay in mammalian cells. Nat Struct Mol Biol. 2013;20:710-7 pubmed publisher
    ..These results corroborate an emerging unified model for NMD substrate recognition, according to which NMD can ensue at every aberrant translation termination event. ..
  5. Silvera D, Arju R, Darvishian F, Levine P, Zolfaghari L, Goldberg J, et al. Essential role for eIF4GI overexpression in the pathogenesis of inflammatory breast cancer. Nat Cell Biol. 2009;11:903-8 pubmed publisher
    ..the unique pathogenic properties of IBC result in part from overexpression of the translation initiation factor eIF4GI in most IBCs...
  6. Marintchev A, Edmonds K, Marintcheva B, Hendrickson E, Oberer M, Suzuki C, et al. Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation. Cell. 2009;136:447-60 pubmed publisher
    ..Free eIF4A is a poor helicase and requires the accessory proteins eIF4G and eIF4H...
  7. Ricci E, Soto Rifo R, Herbreteau C, Decimo D, Ohlmann T. Lentiviral RNAs can use different mechanisms for translation initiation. Biochem Soc Trans. 2008;36:690-3 pubmed publisher
    ..Our results show that HIV-1 is able to drive the synthesis of the Gag polyprotein both by a classical cap-dependent mechanism and an IRES, whereas HIV-2 and SIV appear to use exclusively an IRES mechanism. ..
  8. Comtesse N, Keller A, Diesinger I, Bauer C, Kayser K, Huwer H, et al. Frequent overexpression of the genes FXR1, CLAPM1 and EIF4G located on amplicon 3q26-27 in squamous cell carcinoma of the lung. Int J Cancer. 2007;120:2538-44 pubmed
    ..Three genes, namely FXR1, CLAPM1 and EIF4G, are most frequently overexpressed in the center of the amplified domain in squamous cell carcinomas...
  9. Coldwell M, Morley S. Specific isoforms of translation initiation factor 4GI show differences in translational activity. Mol Cell Biol. 2006;26:8448-60 pubmed
    The eukaryotic initiation factor (eIF) 4GI gene locus (eIF4GI) contains three identified promoters, generating alternately spliced mRNAs, yielding a total of five eIF4GI protein isoforms...
  10. Li W, Belsham G, Proud C. Eukaryotic initiation factors 4A (eIF4A) and 4G (eIF4G) mutually interact in a 1:1 ratio in vivo. J Biol Chem. 2001;276:29111-5 pubmed
    ..These include eIF4G, a modular scaffolding protein, and eIF4A, an RNA helicase, of which two closely related forms are known in ..
  11. Perales C, Carrasco L, Ventoso I. Cleavage of eIF4G by HIV-1 protease: effects on translation. FEBS Lett. 2003;533:89-94 pubmed
    We have recently reported that HIV-1 protease (PR) cleaves the initiation factor of translation eIF4GI [Ventoso et al., Proc. Natl. Acad. Sci. USA 98 (2001) 12966-12971]...
  12. Prévôt D, Decimo D, Herbreteau C, Roux F, Garin J, Darlix J, et al. Characterization of a novel RNA-binding region of eIF4GI critical for ribosomal scanning. EMBO J. 2003;22:1909-21 pubmed
    The eukaryotic translation initiation factor eIF4GI binds several proteins and acts as a scaffold to promote preinitiation complex formation on the mRNA molecule (48S)...
  13. Kang M, Ahn H, Lee J, Matsuhashi S, Park W. Up-regulation of PDCD4 in senescent human diploid fibroblasts. Biochem Biophys Res Commun. 2002;293:617-21 pubmed
    ..domain sharing with death associated protein 5 (DAP5) and a component of eukaryotic translation initiation factor (eIF4G) complex and it might also work as a tumor suppressor...
  14. Lee S, McCormick F. p97/DAP5 is a ribosome-associated factor that facilitates protein synthesis and cell proliferation by modulating the synthesis of cell cycle proteins. EMBO J. 2006;25:4008-19 pubmed
    ..In contrast, overexpression of the C-terminal two-thirds of eukaryotic initiation factor 4GI (eIF4GI), a region that shares significant homology with p97, or the N-terminal MIF4G domain of p97 markedly inhibits ..
  15. Kim W, Back S, Kim V, Ryu I, Jang S. Sequestration of TRAF2 into stress granules interrupts tumor necrosis factor signaling under stress conditions. Mol Cell Biol. 2005;25:2450-62 pubmed
    ..However, the link between these two physiological phenomena has not been clearly elucidated. Here we report that eIF4GI, which is a scaffold protein interacting with many translation factors, interacts with TRAF2, a signaling molecule ..
  16. Byrd M, Zamora M, Lloyd R. Generation of multiple isoforms of eukaryotic translation initiation factor 4GI by use of alternate translation initiation codons. Mol Cell Biol. 2002;22:4499-511 pubmed
    Eukaryotic translation initiation factor 4GI (eIF4GI) is an essential protein that is the target for translational regulation in many cellular processes and viral systems...
  17. Soto Rifo R, Rubilar P, Limousin T, de Breyne S, Decimo D, Ohlmann T. DEAD-box protein DDX3 associates with eIF4F to promote translation of selected mRNAs. EMBO J. 2012;31:3745-56 pubmed publisher
    ..by the DEAD-box helicase DDX3 which can directly bind to the 5' of the target mRNA where it clamps the entry of eIF4F through an eIF4G and Poly A-binding protein cytoplasmic 1 (PABP) double interaction...
  18. Pyronnet S, Imataka H, Gingras A, Fukunaga R, Hunter T, Sonenberg N. Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. EMBO J. 1999;18:270-9 pubmed
    Human eukaryotic translation initiation factor 4E (eIF4E) binds to the mRNA cap structure and interacts with eIF4G, which serves as a scaffold protein for the assembly of eIF4E and eIF4A to form the eIF4F complex...
  19. Schütz P, Bumann M, Oberholzer A, Bieniossek C, Trachsel H, Altmann M, et al. Crystal structure of the yeast eIF4A-eIF4G complex: an RNA-helicase controlled by protein-protein interactions. Proc Natl Acad Sci U S A. 2008;105:9564-9 pubmed publisher
    Translation initiation factors eIF4A and eIF4G form, together with the cap-binding factor eIF4E, the eIF4F complex, which is crucial for recruiting the small ribosomal subunit to the mRNA 5' end and for subsequent scanning and searching ..
  20. Tucci A, Charlesworth G, Sheerin U, Plagnol V, Wood N, Hardy J. Study of the genetic variability in a Parkinson's Disease gene: EIF4G1. Neurosci Lett. 2012;518:19-22 pubmed publisher
    ..and colleagues [2] recently reported mutations in the eukaryotic translation initiation factor 4-gamma (EIF4G1) gene in families with parkinsonism. Large-scale screening found two mutations (p.R1205H and p...
  21. Schulte E, Mollenhauer B, Zimprich A, Bereznai B, Lichtner P, Haubenberger D, et al. Variants in eukaryotic translation initiation factor 4G1 in sporadic Parkinson's disease. Neurogenetics. 2012;13:281-5 pubmed publisher
    Recently, mutations in eukaryotic translation initiation factor 4G1 (EIF4G1) were reported as a rare cause of familial Parkinson's disease (PD)...
  22. Ventoso I, Blanco R, Perales C, Carrasco L. HIV-1 protease cleaves eukaryotic initiation factor 4G and inhibits cap-dependent translation. Proc Natl Acad Sci U S A. 2001;98:12966-71 pubmed
    ..Purified HIV-1 protease directly cleaves eIF4GI at positions 678, 681, and 1086, separating the three domains of this initiation factor...
  23. Chartier Harlin M, Dachsel J, Vilariño Güell C, Lincoln S, Lepretre F, Hulihan M, et al. Translation initiator EIF4G1 mutations in familial Parkinson disease. Am J Hum Genet. 2011;89:398-406 pubmed publisher
    ..3614G>A (p.Arg1205His) in eukaryotic translation initiation factor 4-gamma (EIF4G1). Subsequent sequence and genotype analysis identified EIF4G1 c.1505C>T (p.Ala502Val), c.2056G>T (p...
  24. Gray N, Coller J, Dickson K, Wickens M. Multiple portions of poly(A)-binding protein stimulate translation in vivo. EMBO J. 2000;19:4723-33 pubmed
    ..Our results establish that oocytes contain the machinery necessary to support PAB-mediated translation and suggest that PAB may be an important participant in translational regulation during early development. ..
  25. Gingras A, Raught B, Sonenberg N. eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu Rev Biochem. 1999;68:913-63 pubmed
    Eukaryotic translation initiation factor 4F (eIF4F) is a protein complex that mediates recruitment of ribosomes to mRNA...
  26. Badura M, Braunstein S, Zavadil J, Schneider R. DNA damage and eIF4G1 in breast cancer cells reprogram translation for survival and DNA repair mRNAs. Proc Natl Acad Sci U S A. 2012;109:18767-72 pubmed publisher
    ..in breast cancer cells by selective mRNA translation mediated by high levels of translation initiation factor eIF4G1 (eukaryotic initiation factor 4γ1)...
  27. Shull A, Noonepalle S, Awan F, Liu J, Pei L, Bollag R, et al. RPPA-based protein profiling reveals eIF4G overexpression and 4E-BP1 serine 65 phosphorylation as molecular events that correspond with a pro-survival phenotype in chronic lymphocytic leukemia. Oncotarget. 2015;6:14632-45 pubmed
    ..of protein alterations involved with mRNA translation, specifically upregulation of the translation initiator eIF4G and phosphorylation of the cap-dependent translation inhibitor 4E-BP1 at serine 65...
  28. Ho J, Wang M, Audas T, Kwon D, Carlsson S, Timpano S, et al. Systemic Reprogramming of Translation Efficiencies on Oxygen Stimulus. Cell Rep. 2016;14:1293-1300 pubmed publisher
    ..Two distinct cap-dependent protein synthesis machineries select mRNAs for translation: the normoxic eIF4F and the hypoxic eIF4F(H)...
  29. Sen N, Zhou F, Harris M, Ingolia N, Hinnebusch A. eIF4B stimulates translation of long mRNAs with structured 5' UTRs and low closed-loop potential but weak dependence on eIF4G. Proc Natl Acad Sci U S A. 2016;113:10464-72 pubmed publisher
    ..mRNAs in a fashion mitigated by the ability to form closed-loop messenger ribonucleoprotein particles (mRNPs) via eIF4F-poly(A)-binding protein 1 (Pab1) association, suggesting cooperation between closed-loop assembly and eIF4B/..
  30. Meng X, Firczuk H, Pietroni P, Westbrook R, Dacheux E, Mendes P, et al. Minimum-noise production of translation factor eIF4G maps to a mechanistically determined optimal rate control window for protein synthesis. Nucleic Acids Res. 2017;45:1015-1025 pubmed publisher
    ..b>eIF4G is an essential translation factor that exerts strong control over protein synthesis...
  31. Yamada Y, Sugden C, Williams J. YelA, a putative Dictyostelium translational regulator, acts as antagonist of DIF-1 signaling to control cell-type proportioning. Int J Dev Biol. 2017;61:35-42 pubmed publisher
    ..in YelA, a protein with a region of strong homology to the MIF4G domain of the eukaryotic initiation factor eIF4G. Based upon its domain architecture, which in one important aspect closely resembles that of Death-Associated ..
  32. Connor J, Lyles D. Vesicular stomatitis virus infection alters the eIF4F translation initiation complex and causes dephosphorylation of the eIF4E binding protein 4E-BP1. J Virol. 2002;76:10177-87 pubmed
    ..We tested whether there is a role for eIF4F in this inhibition...
  33. Yángüez E, Castello A, Welnowska E, Carrasco L, Goodfellow I, Nieto A. Functional impairment of eIF4A and eIF4G factors correlates with inhibition of influenza virus mRNA translation. Virology. 2011;413:93-102 pubmed publisher
    ..Now, the requirements for the eIF4A helicase and the eIF4G scaffolding factor have been examined...
  34. Golob Schwarzl N, Krassnig S, Toeglhofer A, Park Y, Gogg Kamerer M, Vierlinger K, et al. New liver cancer biomarkers: PI3K/AKT/mTOR pathway members and eukaryotic translation initiation factors. Eur J Cancer. 2017;83:56-70 pubmed publisher
    ..Phosphorylated (p)-eIF2?, eIF2?, eiF3B, eIF3D, eIF3J, p-eIF4B, eIF4G and eIF6 were upregulated in HCV-associated HCC...
  35. Poornima G, Shah S, Vignesh V, Parker R, Rajyaguru P. Arginine methylation promotes translation repression activity of eIF4G-binding protein, Scd6. Nucleic Acids Res. 2016;44:9358-9368 pubmed
    ..new role was recently reported for a subset of RGG-motif proteins in repressing translation initiation by binding eIF4G1. However the signaling mechanism(s) that leads to spatial and temporal regulation of repression activity of RGG-..
  36. Yan R, Rychlik W, Etchison D, Rhoads R. Amino acid sequence of the human protein synthesis initiation factor eIF-4 gamma. J Biol Chem. 1992;267:23226-31 pubmed
    Eukaryotic protein synthesis initiation factor (eIF) 4 gamma, also known as p220, is a component of the protein complex eIF-4, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary ..
  37. Tsokanos F, Albert M, Demetriades C, Spirohn K, Boutros M, Teleman A. eIF4A inactivates TORC1 in response to amino acid starvation. EMBO J. 2016;35:1058-76 pubmed publisher
    ..We identify here the eIF4A-containing eIF4F translation initiation complex as an upstream regulator of TSC2 in response to amino acid withdrawal in Drosophila ..
  38. Bradley C, Padovan J, Thompson T, Benoit C, Chait B, Rhoads R. Mass spectrometric analysis of the N terminus of translational initiation factor eIF4G-1 reveals novel isoforms. J Biol Chem. 2002;277:12559-71 pubmed
    In eukaryotes, translation initiation factor 4G (eIF4G) acts as the central binding protein for an unusually large number of proteins involved in mRNA metabolism...
  39. Kroczynska B, Sharma B, Eklund E, Fish E, Platanias L. Regulatory effects of programmed cell death 4 (PDCD4) protein in interferon (IFN)-stimulated gene expression and generation of type I IFN responses. Mol Cell Biol. 2012;32:2809-22 pubmed publisher
    ..eukaryotic translation initiation factor 4A (eIF4A) activity and binding to translation initiation factor eIF4G to promote mRNA translation...
  40. Denis C, Richardson R, Park S, Zhang C, Xi W, Laue T, et al. Defining the protein complexome of translation termination factor eRF1: Identification of four novel eRF1-containing complexes that range from 20S to 57S in size. Proteins. 2017;: pubmed publisher
    ..complexes containing eRF1 were both substantially deadenylated and lacking in closed-loop factors eIF4E and eIF4G. The thirteen percent of such translating polysomes that contained poly(A) tails had equivalent levels of eIF4E ..
  41. Freire E, Sturm N, Campbell D, de Melo Neto O. The Role of Cytoplasmic mRNA Cap-Binding Protein Complexes in Trypanosoma brucei and Other Trypanosomatids. Pathogens. 2017;6: pubmed publisher
    ..In other eukaryotes, selection of mRNA for translation is mediated by the complex eIF4F, a heterotrimeric protein complex composed by the subunits eIF4E, eIF4G, and eIF4A, where the eIF4E binds to the 5'..
  42. Tudor J, Davis E, Peixoto L, Wimmer M, van Tilborg E, Park A, et al. Sleep deprivation impairs memory by attenuating mTORC1-dependent protein synthesis. Sci Signal. 2016;9:ra41 pubmed publisher
    ..mTORC1-mediated phosphorylation of 4EBP2 and the interaction between eukaryotic initiation factor 4E (eIF4E) and eIF4G in the hippocampi of sleep-deprived mice...
  43. Kumar K, Lohmann K, Klein C. Genetics of Parkinson disease and other movement disorders. Curr Opin Neurol. 2012;25:466-74 pubmed publisher
    ..Using a different technique, that is linkage analysis, mutations in EIF4G1 were implicated as a cause of Parkinson disease and mutations in SLC20A2 as a cause of familial idiopathic basal ..
  44. Leen E, Sorgeloos F, Correia S, Chaudhry Y, Cannac F, Pastore C, et al. A Conserved Interaction between a C-Terminal Motif in Norovirus VPg and the HEAT-1 Domain of eIF4G Is Essential for Translation Initiation. PLoS Pathog. 2016;12:e1005379 pubmed publisher
    ..For murine norovirus (MNV) we previously showed that VPg binds to the middle fragment of eIF4G (4GM; residues 652-1132)...
  45. Gratia M, Vende P, Charpilienne A, Baron H, Laroche C, Sarot E, et al. Challenging the Roles of NSP3 and Untranslated Regions in Rotavirus mRNA Translation. PLoS ONE. 2016;11:e0145998 pubmed publisher
    ..that the last four GACC nucleotides of viral mRNA are essential for efficient translation and that both the NSP3 eIF4G- and RNA-binding domains are required...
  46. Volpon L, Osborne M, Capul A, de la Torre J, Borden K. Structural characterization of the Z RING-eIF4E complex reveals a distinct mode of control for eIF4E. Proc Natl Acad Sci U S A. 2010;107:5441-6 pubmed publisher
    ..One class of eIF4E regulators, including eIF4G and the 4E-binding proteins (4E-BPs), interact with eIF4E using a conserved YXXXXLPhi-binding site...
  47. Márquez Mota C, Rodriguez Gaytan C, Adjibade P, Mazroui R, Galvez A, Granados O, et al. The mTORC1-Signaling Pathway and Hepatic Polyribosome Profile Are Enhanced after the Recovery of a Protein Restricted Diet by a Combination of Soy or Black Bean with Corn Protein. Nutrients. 2016;8: pubmed
    ..the highest body weight gain; rats fed BCr had the highest pS6K1/S6K1 ratio; rats fed B, BCr or P had the highest eIF4G expression; (2) In total, 84 rats were fed 0.5% C for 21 day and protein rehabilitated with different proteins...
  48. Sugiyama H, Takahashi K, Yamamoto T, Iwasaki M, Narita M, Nakamura M, et al. Nat1 promotes translation of specific proteins that induce differentiation of mouse embryonic stem cells. Proc Natl Acad Sci U S A. 2017;114:340-345 pubmed publisher
    ..protein that is homologous to the C-terminal two thirds of eukaryotic translation initiation factor 4G (Eif4g1). We previously showed that Nat1-null mouse embryonic stem cells (mES cells) are resistant to differentiation...
  49. Gallie D. Eukaryotic Initiation Factor eIFiso4G1 and eIFiso4G2 Are Isoforms Exhibiting Distinct Functional Differences in Supporting Translation in Arabidopsis. J Biol Chem. 2016;291:1501-13 pubmed publisher
    ..Although many eukaryotes express two eIF4G isoforms that are highly similar, the eIF4G isoforms in plants, referred to as eIF4G and eIFiso4G, are highly ..
  50. Vitour D, Lindenbaum P, Vende P, Becker M, Poncet D. RoXaN, a novel cellular protein containing TPR, LD, and zinc finger motifs, forms a ternary complex with eukaryotic initiation factor 4G and rotavirus NSP3. J Virol. 2004;78:3851-62 pubmed
    ..binds the 3' consensus sequence of viral mRNAs and interacts with the eukaryotic translation initiation factor eIF4G I...
  51. May J, Johnson P, Saleem H, Simon A. A Sequence-Independent, Unstructured Internal Ribosome Entry Site Is Responsible for Internal Expression of the Coat Protein of Turnip Crinkle Virus. J Virol. 2017;91: pubmed publisher
    ..The IRES was dependent on eIF4G, but not eIF4E, for activity...
  52. Dorrello N, Peschiaroli A, Guardavaccaro D, Colburn N, Sherman N, Pagano M. S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth. Science. 2006;314:467-71 pubmed
    ..We propose that regulated degradation of PDCD4 in response to mitogens allows efficient protein synthesis and consequently cell growth. ..
  53. Ryu I, Park J, An S, Kwon O, Jang S. eIF4GI facilitates the MicroRNA-mediated gene silencing. PLoS ONE. 2013;8:e55725 pubmed publisher
    ..we show that human Ago2 associates with the cap-binding protein complex and this association is mediated by human eIF4GI, a scaffold protein required for the translation initiation...
  54. Firdaus S, Dhasmana A, Wahid M, Jawed A, Mandal R, Dar S, et al. Fullerenes May Cause eIF Mediated Perturbation in Translational Machinery: Evidence from in-silico Analysis. Ann Clin Lab Sci. 2017;47:409-415 pubmed
    ..their functional partners in the presence/absence of fullerenes display reduced activity of eIF2, eIF4A, eIF4H, eIF4G, eIF4B, eIF5B, and eEF1 with fullerenes of different molecular weights...
  55. Coldwell M, Hashemzadeh Bonehi L, Hinton T, Morley S, Pain V. Expression of fragments of translation initiation factor eIF4GI reveals a nuclear localisation signal within the N-terminal apoptotic cleavage fragment N-FAG. J Cell Sci. 2004;117:2545-55 pubmed
    The eukaryotic initiation factor eIF4GI plays a central role in the assembly of a competent initiation complex at the 5' end of an mRNA. Five isoforms of eIF4G exist in cells, arising from alternative translation initiation...
  56. Feoktistova K, Tuvshintogs E, Do A, Fraser C. Human eIF4E promotes mRNA restructuring by stimulating eIF4A helicase activity. Proc Natl Acad Sci U S A. 2013;110:13339-44 pubmed publisher
    ..To explain these findings, we show that the eIF4E-binding site in eukaryotic initiation factor 4G (eIF4G) functions as an autoinhibitory domain to modulate its ability to stimulate eIF4A helicase activity...
  57. Lu J, Bergman N, Sadri N, Schneider R. Assembly of AUF1 with eIF4G-poly(A) binding protein complex suggests a translation function in AU-rich mRNA decay. RNA. 2006;12:883-93 pubmed
    ..We demonstrate that all four AUF1 protein isoforms bind directly and strongly to initiation factor eIF4G at a C-terminal site regardless of AUF1 interaction with the ARE...
  58. Morris C, Wittmann J, Jack H, Jalinot P. Human INT6/eIF3e is required for nonsense-mediated mRNA decay. EMBO Rep. 2007;8:596-602 pubmed
    ..From these observations, we propose that INT6, in association with eIF3, is involved in routing specific mRNAs for degradation...
  59. Bell T, Espina V, Senina S, Woodson C, Brahms A, Carey B, et al. Rapamycin modulation of p70 S6 kinase signaling inhibits Rift Valley fever virus pathogenesis. Antiviral Res. 2017;143:162-175 pubmed publisher
    ..Here we demonstrated phosphorylation of p70 S6 kinase, S6 ribosomal protein, and eIF4G following RVFV infection in vitro through western blot analysis and in a mouse model of infection through reverse ..
  60. Avanzino B, Fuchs G, Fraser C. Cellular cap-binding protein, eIF4E, promotes picornavirus genome restructuring and translation. Proc Natl Acad Sci U S A. 2017;114:9611-9616 pubmed publisher
    ..First, eIF4E binding to eIF4G generates a high-affinity binding conformation of the eIF4F complex for the IRES...
  61. Hinton T, Coldwell M, Carpenter G, Morley S, Pain V. Functional analysis of individual binding activities of the scaffold protein eIF4G. J Biol Chem. 2007;282:1695-708 pubmed
    ..The eIF3-eIF4GI interaction is believed to forge the link between the 40 S subunit and the mRNA...
  62. Rissland O, Subtelny A, Wang M, Lugowski A, Nicholson B, Laver J, et al. The influence of microRNAs and poly(A) tail length on endogenous mRNA-protein complexes. Genome Biol. 2017;18:211 pubmed publisher
    ..scale, how microRNA-mediated repression modulates the associations of the core mRNP components eIF4E, eIF4G, and PABP and of the decay factor DDX6 in human cells...
  63. Eberle J, Krasagakis K, Orfanos C. Translation initiation factor eIF-4A1 mRNA is consistently overexpressed in human melanoma cells in vitro. Int J Cancer. 1997;71:396-401 pubmed
    ..Cultures of congenital melanocytic nevi exhibited intermediate expression of eIF-4A1. Thus, eIF-4A1 overexpression seems to be an important feature of melanoma cells and might contribute to their malignant transformation. ..
  64. Lejeune F, Ranganathan A, Maquat L. eIF4G is required for the pioneer round of translation in mammalian cells. Nat Struct Mol Biol. 2004;11:992-1000 pubmed
    ..We show that baculovirus-produced CBP80 and CBP20 independently interact with eIF4GI. The interactions between eIF4G and the heterodimer CBP80/20 suggest that eIF4G has a function in the pioneer ..
  65. Greenberg V, Zimmer S. Paclitaxel induces the phosphorylation of the eukaryotic translation initiation factor 4E-binding protein 1 through a Cdk1-dependent mechanism. Oncogene. 2005;24:4851-60 pubmed
    ..Taken together, our data suggest that PTX-increases the functional level of eIF-4E by promoting the hyperphosphorylation and release of 4E-BP1 through a cdk1-dependent mechanism. ..
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    The R1205H mutation in the eukaryotic translation initiation factor 4G1 (EIF4G1) gene and the D620N mutation in the vacuolar protein sorting 35 (VPS35) gene were recently found in patients with autosomal dominant or sporadic forms of ..
  67. Lamphear B, Yan R, Yang F, Waters D, Liebig H, Klump H, et al. Mapping the cleavage site in protein synthesis initiation factor eIF-4 gamma of the 2A proteases from human Coxsackievirus and rhinovirus. J Biol Chem. 1993;268:19200-3 pubmed
    ..The cleavage site for both proteases is 479GRPALSSR decreases GPPRGGPG494 in rabbit eIF-4 gamma, corresponding to 478GRTTLSTR decreases GPPRGGPG493 in human eIF-4 gamma. ..
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    Eukaryotic translation initiation factor 4-gamma 1 (EIF4G1) gene mutations have recently been reported in autosomal dominant, late-onset Parkinson's disease (LOPD)...
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    ..Leptin increased eukaryotic initiation factor (eIF) 2alpha, eIF2B activity, and the eIF4E-eIF4G complex, while it decreased the inhibitory complex of eIF4E with the eIF4E-binding protein-1 (4E-BP1)...
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    ..eIF-4gamma is encoded by an amplified gene and possibly plays a crucial part in the development of squamous cell lung carcinoma. ..
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    ..eIFs) 1, 1A, 2, 3, 4A, 4B and 4G, and the poly(C) binding protein 2 (PCBP2), and starts with specific binding of eIF4G/eIF4A to d11...
  72. Huttenlocher J, Krüger R, Capetian P, Lohmann K, Brockmann K, Csoti I, et al. EIF4G1 is neither a strong nor a common risk factor for Parkinson's disease: evidence from large European cohorts. J Med Genet. 2015;52:37-41 pubmed publisher
    Missense mutations in the eukaryotic translation initiation factor 4-γ 1 (EIF4G1) gene have previously been implicated in familial Parkinson's disease (PD)...
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    ..also establish that SKAR is present in cap-binding CBP80 immune complexes and that this interaction is mediated by eIF4G. We demonstrate that inducible protein expression of key IFN-?-regulated protein products such as ISG15 and p21(..
  74. Robalino J, Joshi B, Fahrenkrug S, Jagus R. Two zebrafish eIF4E family members are differentially expressed and functionally divergent. J Biol Chem. 2004;279:10532-41 pubmed
    ..The ability of these two zebrafish proteins to bind m(7)GTP, eIF4G, and 4E-BP, as well as to complement yeast conditionally deficient in functional eIF4E, show that eIF4E-1A is a ..
  75. Lai M, Wang S, Cheng L, Tarn W, Tsai S, Sun H. Human DDX3 interacts with the HIV-1 Tat protein to facilitate viral mRNA translation. PLoS ONE. 2013;8:e68665 pubmed publisher
    ..Taken together, these findings indicate that DDX3 is recruited to the TAR hairpin by interaction with viral Tat to facilitate HIV-1 mRNA translation. ..
  76. Horton L, Bushell M, Barth Baus D, Tilleray V, Clemens M, Hensold J. p53 activation results in rapid dephosphorylation of the eIF4E-binding protein 4E-BP1, inhibition of ribosomal protein S6 kinase and inhibition of translation initiation. Oncogene. 2002;21:5325-34 pubmed
    ..These data provide evidence that modulation of translational activity constitutes a further mechanism by which the growth inhibitory effects of p53 may be mediated. ..
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    ..2) a transient decrease in the phosphorylated gamma-form of 4E-BP1, and 3) a sustained decrease in the amount of eIF4G associated with eIF4E...
  78. Farrell P, Hernandez J, Fedele M, Vary T, Kimball S, Jefferson L. Eukaryotic initiation factors and protein synthesis after resistance exercise in rats. J Appl Physiol (1985). 2000;88:1036-42 pubmed
    ..eIF4E complexed to eIF4G (eIF4E x eIF4G), eIF4E binding protein 1 (4E-BP1) complexed to eIF4E, and phosphorylation state of eIF4E and 4E-..
  79. Shives K, Massey A, May N, Morrison T, Beckham J. 4EBP-Dependent Signaling Supports West Nile Virus Growth and Protein Expression. Viruses. 2016;8: pubmed
    ..translation initiation factor 4E-binding protein (4EBP/eIF4E) interaction and eukaryotic initiation factor 4F (eIF4F) complex formation to support viral growth and viral protein expression...