EIF1

Summary

Gene Symbol: EIF1
Description: eukaryotic translation initiation factor 1
Alias: A121, EIF-1, EIF1A, ISO1, SUI1, eukaryotic translation initiation factor 1, protein translation factor SUI1 homolog, sui1iso1
Species: human
Products:     EIF1

Top Publications

  1. Ivanov I, Loughran G, Sachs M, Atkins J. Initiation context modulates autoregulation of eukaryotic translation initiation factor 1 (eIF1). Proc Natl Acad Sci U S A. 2010;107:18056-60 pubmed publisher
    ..Eukaryotic initiation factor 1 (eIF1) plays a central role in this process...
  2. Sehrawat U, Koning F, Ashkenazi S, Stelzer G, Leshkowitz D, Dikstein R. Cancer-Associated Eukaryotic Translation Initiation Factor 1A Mutants Impair Rps3 and Rps10 Binding and Enhance Scanning of Cell Cycle Genes. Mol Cell Biol. 2019;39: pubmed publisher
    ..Eukaryotic translation initiation factor 1A (eIF1A) plays a key role in scanning and AUG selection and differentially affects the translation of distinct mRNAs...
  3. Liu X, Luo C, Deng K, Wu Z, Wei Y, Jiang J, et al. Cytoplasmic volume of recipient oocytes affects the nucleus reprogramming and the developmental competence of HMC buffalo (Bubalus bubalis) embryos. J Vet Med Sci. 2018;80:1291-1300 pubmed publisher
    ..05). Furthermore, the expression of embryonic genome activation (EGA) relative genes (eIF1A and U2AF) in HMC embryos derived from ~225% cytoplasm at the 8-cell stages was also found to be enhanced compared ..
  4. Zheng A, Yamamoto R, Sokabe M, Tanaka I, Yao M. Crystallization and preliminary X-ray crystallographic analysis of eIF5BΔN and the eIF5BΔN-eIF1AΔN complex. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011;67:730-3 pubmed publisher
    The binding between two universally conserved translation initiation factors, eIF5B and eIF1A, is important in the initiation step of eukaryotic protein synthesis on the ribosome...
  5. Šekoranja D, Bostjancic E, Salapura V, Mavcic B, Pizem J. Primary aneurysmal bone cyst with a novel SPARC-USP6 translocation identified by next-generation sequencing. Cancer Genet. 2018;228-229:12-16 pubmed publisher
    ..Including our case, the list of currently known USP6 fusion partners in primary ABC include: CDH11, CNBP, COL1A1, CTNNB1, EIF1, FOSL2, OMD, PAFAH1B1, RUNX2, SEC31A, SPARC, STAT3 and THRAP3.
  6. Grossmann K, Hutzler J, Tresch S, Christiansen N, Looser R, Ehrhardt T. On the mode of action of the herbicides cinmethylin and 5-benzyloxymethyl-1, 2-isoxazolines: putative inhibitors of plant tyrosine aminotransferase. Pest Manag Sci. 2012;68:482-92 pubmed publisher
    ..cinmethylin and 5-benzyloxymethyl-1,2-isoxazolines substituted with methylthiophene (methiozolin) or pyridine (ISO1, ISO2) was investigated...
  7. Moens T, Niccoli T, Wilson K, Atilano M, Birsa N, Gittings L, et al. C9orf72 arginine-rich dipeptide proteins interact with ribosomal proteins in vivo to induce a toxic translational arrest that is rescued by eIF1A. Acta Neuropathol. 2019;137:487-500 pubmed publisher
    ..Expression of the translation initiation factor eIF1A uniquely rescued DPR-induced toxicity in vivo, indicating that restoring translation is a potential therapeutic ..
  8. Ross J, Bressler K, Thakor N. Eukaryotic Initiation Factor 5B (eIF5B) Cooperates with eIF1A and eIF5 to Facilitate uORF2-Mediated Repression of ATF4 Translation. Int J Mol Sci. 2018;19: pubmed publisher
    ..Further experiments suggest that eIF5B cooperates with eIF1A and eIF5, but not eIF2A, to facilitate the uORF2-mediated repression of ATF4 translation.
  9. Charles Antony A, Alone P. Fidelity of HIS4 start codon selection influences 3-amino-1,2,4-triazole sensitivity in GTPase activating protein function defective eIF5. J Genet. 2018;97:953-964 pubmed
    ..The overexpression of eIF1 improved expression of HIS4AUG allele and GCN4 transcript causing 3AT resistance, ..

More Information

Publications93

  1. Krishnamoorthy G, Davidson N, Leach S, Zhao Z, Lowe S, Lee G, et al. EIF1AX and RAS Mutations Cooperate to Drive Thyroid Tumorigenesis through ATF4 and c-MYC. Cancer Discov. 2019;9:264-281 pubmed publisher
    ..Eukaryotic initiation factor 1A (EIF1A) is essential for recruitment of the ternary complex and for assembling the 43S PIC...
  2. Zhang F, Saini A, Shin B, Nanda J, Hinnebusch A. Conformational changes in the P site and mRNA entry channel evoked by AUG recognition in yeast translation preinitiation complexes. Nucleic Acids Res. 2015;43:2293-312 pubmed publisher
    ..We compared patterns of hydroxyl radical cleavage of rRNA by Fe(II)-BABE tethered to unique sites in eIF1A in yeast PICs reconstituted with mRNA harboring an AUG or near-cognate (AUC) start codon...
  3. Tervaniemi M, Katayama S, Skoog T, Siitonen H, Vuola J, Nuutila K, et al. Intracellular signalling pathways and cytoskeletal functions converge on the psoriasis candidate gene CCHCR1 expressed at P-bodies and centrosomes. BMC Genomics. 2018;19:432 pubmed publisher
    ..Here we utilized RNA sequencing (RNAseq) using HEK293 cells overexpressing isoforms 1 or 3 (Iso1, Iso3 cells), in combination with the coding non-risk or risk (*WWCC) haplotype of CCHCR1...
  4. Fearnley G, Bruns A, Wheatcroft S, Ponnambalam S. VEGF-A isoform-specific regulation of calcium ion flux, transcriptional activation and endothelial cell migration. Biol Open. 2015;4:731-42 pubmed publisher
    ..which was proportional to the subsequent rise in cytosolic calcium ions, in comparison to cells treated with VEGF-A121. A major consequence of this VEGF-A isoform-specific calcium ion flux in endothelial cells is differential ..
  5. Fräsdorf B, Radon C, Leimkühler S. Characterization and interaction studies of two isoforms of the dual localized 3-mercaptopyruvate sulfurtransferase TUM1 from humans. J Biol Chem. 2014;289:34543-56 pubmed publisher
    ..Here, we purified and characterized two novel TUM1 splice variants, designated as TUM1-Iso1 and TUM1-Iso2. The purified proteins showed similar kinetic behavior and comparable pH and temperature dependence...
  6. Yu J, Marintchev A. Comparative sequence and structure analysis of eIF1A and eIF1AD. BMC Struct Biol. 2018;18:11 pubmed publisher
    Eukaryotic translation initiation factor 1A (eIF1A) is universally conserved in all organisms...
  7. Li W, Klovstad M, Schüpbach T. Repression of Gurken translation by a meiotic checkpoint in Drosophila oogenesis is suppressed by a reduction in the dose of eIF1A. Development. 2014;141:3910-21 pubmed publisher
    ..In a screen for modifiers of the oocyte DV patterning defects, we identified a mutation in the eIF1A gene as a dominant suppressor...
  8. Thakur A, Hinnebusch A. eIF1 Loop 2 interactions with Met-tRNAi control the accuracy of start codon selection by the scanning preinitiation complex. Proc Natl Acad Sci U S A. 2018;115:E4159-E4168 pubmed publisher
    ..b>eIF1 binds to the 40S subunit and exerts a dual role of enhancing TC binding to the open PIC conformation while ..
  9. Hussain T, Llácer J, Fernández I, Muñoz A, Martin Marcos P, Savva C, et al. Structural changes enable start codon recognition by the eukaryotic translation initiation complex. Cell. 2014;159:597-607 pubmed publisher
    ..The structure reveals stabilization of the codon-anticodon duplex by the N-terminal tail of eIF1A, changes in the structure of eIF1 likely instrumental in its subsequent release, and changes in the conformation ..
  10. Solares E, Chakraborty M, Miller D, Kalsow S, Hall K, Perera A, et al. Rapid Low-Cost Assembly of the Drosophila melanogaster Reference Genome Using Low-Coverage, Long-Read Sequencing. G3 (Bethesda). 2018;8:3143-3154 pubmed publisher
    ..Here we resequenced the reference strain of D. melanogaster (ISO1) on a single Oxford Nanopore MinION flow cell run for 24 hr...
  11. Wen H, Kumar V, Lan X, Shoshtari S, Eng J, Zhou X, et al. APOL1 risk variants cause podocytes injury through enhancing endoplasmic reticulum stress. Biosci Rep. 2018;38: pubmed publisher
    ..protein ((GRP78), also known as the binding Ig protein, BiP) and the phosphorylation of the eukaryotic translation initiation factor 1 (eIF1) were significantly elevated in the G1/HPs and G2/HPs, suggesting a possible occurrence of ..
  12. Rezende A, Assis L, Nunes E, da Costa Lima T, Marchini F, Freire E, et al. The translation initiation complex eIF3 in trypanosomatids and other pathogenic excavates--identification of conserved and divergent features based on orthologue analysis. BMC Genomics. 2014;15:1175 pubmed publisher
    ..lack of association of the eIF3j subunit to the complex whilst highlighting the strong interaction between eIF3 and eIF1. The presence of most eIF3 subunits in trypanosomatids is consistent with an early evolution of a fully functional ..
  13. Nemoto N, Singh C, Udagawa T, Wang S, Thorson E, Winter Z, et al. Yeast 18 S rRNA is directly involved in the ribosomal response to stringent AUG selection during translation initiation. J Biol Chem. 2010;285:32200-12 pubmed publisher
    ..Two of the isolated mutations, G875A, altering the core of the platform domain that binds eIF1 and eIF2, and A1193U, changing the h31 loop located below the P-site tRNA(i)(Met), show phenotypes indicating ..
  14. Baade I, Spillner C, Schmitt K, Valerius O, Kehlenbach R. Extensive Identification and In-depth Validation of Importin 13 Cargoes. Mol Cell Proteomics. 2018;17:1337-1353 pubmed publisher
    ..Using stringent criteria, we identified 255 importin 13 substrates, including the known cargoes Ubc9, Mago and eIF1A, and validate many of them as transport cargoes by extensive biochemical and cell biological characterization...
  15. Goya S, Wada T, Shimada K, Hirao D, Tanaka R. Dose-dependent effects of isoflurane and dobutamine on cardiovascular function in dogs with experimental mitral regurgitation. Vet Anaesth Analg. 2018;45:432-442 pubmed publisher
    ..First, anaesthesia was maintained at an end-tidal isoflurane concentration (Fe'Iso) 1.0% (ISO1.0) for 20 minutes...
  16. Pisareva V, Pisarev A. eIF5 and eIF5B together stimulate 48S initiation complex formation during ribosomal scanning. Nucleic Acids Res. 2014;42:12052-69 pubmed publisher
    ..Mutational analysis of eIF1A and eIF5B revealed distinct functions of eIF5B in 48S IC formation and subunit joining.
  17. Lan X, Li D, Zhong B, Ren J, Wang X, Sun Q, et al. Identification of differentially expressed genes related to metabolic syndrome induced with high-fat diet in E3 rats. Exp Biol Med (Maywood). 2015;240:235-41 pubmed publisher
    ..The expression of four genes (Alb, Pip4k2a, Scd1, and Tf) known to be associated with MetS and other five genes (Eif1, Rnase4, Rps12, Rup2, and Tmsb4) unknown to be relevant to MetS was significantly up-regulated in the livers of HFD-..
  18. Herrmannová A, Daujotyte D, Yang J, Cuchalová L, Gorrec F, Wagner S, et al. Structural analysis of an eIF3 subcomplex reveals conserved interactions required for a stable and proper translation pre-initiation complex assembly. Nucleic Acids Res. 2012;40:2294-311 pubmed publisher
    ..Leaky scanning is also partially suppressed by eIF1, one of the key regulators of AUG recognition, and its mutant sui1(G107R) but the mechanism differs...
  19. Erzberger J, Stengel F, Pellarin R, Zhang S, Schaefer T, Aylett C, et al. Molecular architecture of the 40Sâ‹…eIF1â‹…eIF3 translation initiation complex. Cell. 2014;158:1123-1135 pubmed publisher
    ..and integrative structure modeling, allowed us to position and orient all eIF3 components on the 40Sâ‹…eIF1 complex, revealing an extended, modular arrangement of eIF3 subunits...
  20. Fesquet D, de Bettignies G, Bellis M, Espeut J, Devault A. Binding of Kif23-iso1/CHO1 to 14-3-3 is regulated by sequential phosphorylations at two LATS kinase consensus sites. PLoS ONE. 2015;10:e0117857 pubmed publisher
    ..Finally, we provide evidence that Kif23 is largely unphosphorylated on S814 in post-abscission midbodies, making this Kif23 post-translational modification a potential marker to probe these structures. ..
  21. Haimov O, Sehrawat U, Tamarkin Ben Harush A, Bahat A, Uzonyi A, Will A, et al. Dynamic Interaction of Eukaryotic Initiation Factor 4G1 (eIF4G1) with eIF4E and eIF1 Underlies Scanning-Dependent and -Independent Translation. Mol Cell Biol. 2018;38: pubmed publisher
    ..eIF4G1 also associates with eIF1, and both promote scanning and AUG selection...
  22. Du Y, Hu H, Hua C, Du K, Wei T. Tissue distribution, subcellular localization, and enzymatic activity analysis of human SIRT5 isoforms. Biochem Biophys Res Commun. 2018;503:763-769 pubmed publisher
    ..In human beings, SIRT5 gene encodes for four SIRT5 protein isoforms, namely SIRT5iso1, SIRT5iso2, SIRT5iso3, and SIRT5iso4...
  23. Karyagyna A, Vassiliev M, Ershova A, Nurtdinov R, Lossev I. Probe-Level Universal Search (PLUS) algorithm for gender differentiation in affymetrix datasets. J Bioinform Comput Biol. 2010;8:553-77 pubmed
    ..the set consists of 38 probes from XIST gene of X-chromosome and 17 probes from five Y-chromosome genes: RPS4Y1, EIF1A, DDX3Y, JARID1D and USP9Y...
  24. Lam P, Zhao L, Eveleigh N, Yu Y, Chen X, Kunst L. The exosome and trans-acting small interfering RNAs regulate cuticular wax biosynthesis during Arabidopsis inflorescence stem development. Plant Physiol. 2015;167:323-36 pubmed publisher
    ..of five additional genes (EARLY RESPONSE TO DEHYDRATION14, AUXIN RESISTANT1, a translation initiation factor SUI1 family protein, and two genes of unknown function) is controlled by both CER7 and trans-acting small interfering ..
  25. Zheng A, Yu J, Yamamoto R, Ose T, Tanaka I, Yao M. X-ray structures of eIF5B and the eIF5B-eIF1A complex: the conformational flexibility of eIF5B is restricted on the ribosome by interaction with eIF1A. Acta Crystallogr D Biol Crystallogr. 2014;70:3090-8 pubmed publisher
    eIF5B and eIF1A are two translation-initiation factors that are universally conserved among all kingdoms. They show a unique interaction in eukaryotes which is important for ribosomal subunit joining...
  26. Samuel R, Farrukh S, Rehmat S, Hanif M, Ahmed S, Musharraf S, et al. Soluble Production of Human Recombinant VEGF-A121 by Using SUMO Fusion Technology in Escherichia coli. Mol Biotechnol. 2018;60:585-594 pubmed publisher
    Human recombinant vascular endothelial growth factor-A121 (hrVEGF-A121) has applications in pharmaceutical industry especially in regenerative medicine...
  27. ElAntak L, Wagner S, Herrmannová A, Karásková M, Rutkai E, Lukavsky P, et al. The indispensable N-terminal half of eIF3j/HCR1 cooperates with its structurally conserved binding partner eIF3b/PRT1-RRM and with eIF1A in stringent AUG selection. J Mol Biol. 2010;396:1097-116 pubmed publisher
    ..the key tryptophan residues results in the severe leaky scanning phenotype partially suppressible by overexpressed eIF1A, which is thought to stabilize properly formed preinitiation complexes at the correct start codon...
  28. Fearnley G, Smith G, Abdul Zani I, Yuldasheva N, Mughal N, Homer Vanniasinkam S, et al. VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis. Biol Open. 2016;5:571-83 pubmed publisher
    ..on these concepts, our study shows for the first time that three different VEGF-A isoforms (VEGF-A165, VEGF-A121 and VEGF-A145) promote distinct patterns of VEGFR2 endocytosis for delivery into early endosomes...
  29. Karásková M, Gunišová S, Herrmannová A, Wagner S, Munzarová V, Valášek L. Functional characterization of the role of the N-terminal domain of the c/Nip1 subunit of eukaryotic initiation factor 3 (eIF3) in AUG recognition. J Biol Chem. 2012;287:28420-34 pubmed publisher
    ..Several initiation factors that ensure high fidelity of AUG recognition were identified previously, including eIF1A, eIF1, eIF2, and eIF5...
  30. Fu X, Zheng D, Liao J, Li Q, Lin Y, Zhang D, et al. Alternatively spliced products lacking exon 12 dominate the expression of fragile X mental retardation 1 gene in human tissues. Mol Med Rep. 2015;12:1957-62 pubmed publisher
    ..The isoform that consisted of the entire FMR1 coding region (ISO1) accounted for a small proportion of all isoforms. Isoforms lacking exon 12 were the most abundant...
  31. Ushigome M, Nabeya Y, Soda H, Takiguchi N, Kuwajima A, Tagawa M, et al. Multi-panel assay of serum autoantibodies in colorectal cancer. Int J Clin Oncol. 2018;23:917-923 pubmed publisher
    ..Autoantibodies against 17 tumor antigens (p53, RalA, HSP70, Galectin1, KM-HN-1, NY-ESO-1, p90, Sui1, HSP40, CyclinB1, HCC-22-5, c-myc, PrxVI, VEGF, HCA25a, p62, and Annexin II) were evaluated in 279 patients with ..
  32. Labbé P, Faure E, Lecointe S, Le Scouarnec S, Kyndt F, Marrec M, et al. The alternatively spliced LRRFIP1 Isoform-1 is a key regulator of the Wnt/?-catenin transcription pathway. Biochim Biophys Acta Mol Cell Res. 2017;1864:1142-1152 pubmed publisher
    ..In contrast, LRRFIP1-Iso1 and -2 are primarily located in the cell nucleus in part thanks to their shared C-terminal domain...
  33. Boman E, Rossi M, Kapanen M. The robustness of dual isocenter VMAT radiation therapy for bilateral lymph node positive breast cancer. Phys Med. 2017;44:11-17 pubmed publisher
    ..VMAT planning techniques: dual-isocenter split-arc VMAT plans (Iso2) were compared with mono-isocenter VMAT plans (Iso1)...
  34. Haimov O, Sinvani H, Martin F, Ulitsky I, Emmanuel R, Tamarkin Ben Harush A, et al. Efficient and Accurate Translation Initiation Directed by TISU Involves RPS3 and RPS10e Binding and Differential Eukaryotic Initiation Factor 1A Regulation. Mol Cell Biol. 2017;37: pubmed publisher
    ..We further demonstrate that TISU is particularly dependent on eukaryotic initiation factor 1A (eIF1A) which interacts with both RPS3 and RPS10e...
  35. Visweswaraiah J, PITTMAN Y, Dever T, Hinnebusch A. The β-hairpin of 40S exit channel protein Rps5/uS7 promotes efficient and accurate translation initiation in vivo. elife. 2015;4:e07939 pubmed publisher
    ..leaky-scanning' of AUGs; and lowered initiation fidelity by exacerbating the effect of poor context of the eIF1 AUG codon to reduce eIF1 abundance...
  36. Battini F, Bernardi R, Turrini A, Agnolucci M, Giovannetti M. Rhizophagus intraradices or its associated bacteria affect gene expression of key enzymes involved in the rosmarinic acid biosynthetic pathway of basil. Mycorrhiza. 2016;26:699-707 pubmed publisher
    ..TAT), hydroxyphenylpyruvate reductase (HPPR) and p-coumaroyl shikimate 3'-hydroxylase isoform 1 (CS3'H iso1) genes, 5.7-fold, 2-fold and 2.4-fold, respectively, in O. basilicum leaves. By contrast, inoculation with R...
  37. Jaafar Z, Oguro A, Nakamura Y, Kieft J. Translation initiation by the hepatitis C virus IRES requires eIF1A and ribosomal complex remodeling. elife. 2016;5: pubmed publisher
    ..We discovered that eIF1A is necessary for efficient activity where it stabilizes tRNA binding and inspects the codon-anticodon interaction, ..
  38. Nag N, Lin K, Edmonds K, Yu J, Nadkarni D, Marintcheva B, et al. eIF1A/eIF5B interaction network and its functions in translation initiation complex assembly and remodeling. Nucleic Acids Res. 2016;44:7441-56 pubmed publisher
    ..Another protein, eIF1A, is involved in virtually all steps, including subunit joining...
  39. Garcia Esparcia P, Hernández Ortega K, Koneti A, Gil L, Delgado Morales R, Castaño E, et al. Altered machinery of protein synthesis is region- and stage-dependent and is associated with α-synuclein oligomers in Parkinson's disease. Acta Neuropathol Commun. 2015;3:76 pubmed publisher
    ..Altered levels of eIF3 and eIF1, and decrease eEF1A and eEF2 protein levels were observed in the frontal cortex in PD...
  40. Poimenidi E, Theodoropoulou C, Koutsioumpa M, Skondra L, Droggiti E, van den Broek M, et al. Vascular endothelial growth factor A (VEGF-A) decreases expression and secretion of pleiotrophin in a VEGF receptor-independent manner. Vascul Pharmacol. 2016;80:11-9 pubmed publisher
    ..VEGF-A121 also decreased PTN mRNA and protein levels, suggesting that heparin binding of VEGF-A165 is not involved...
  41. Hamada N, Ito H, Nishijo T, Iwamoto I, Morishita R, Tabata H, et al. Essential role of the nuclear isoform of RBFOX1, a candidate gene for autism spectrum disorders, in the brain development. Sci Rep. 2016;6:30805 pubmed publisher
    ..Since pathophysiological significance of the dominant nuclear isoform in neurons, RBFOX1-isoform1 (iso1), remains to be elucidated, we performed comprehensive analyses of Rbfox1-iso1 during mouse corticogenesis...
  42. Huang W, Dong Y, Zhao G, Wang Y, Jiang J, Zhao P. Influence of isoflurane exposure in pregnant rats on the learning and memory of offsprings. BMC Anesthesiol. 2018;18:5 pubmed publisher
    ..Forty-eight SpragueDawley (SD) pregnant rats were randomly divided into 3 groups and inhaled 1.3% isoflurane (the Iso1 group), 2.0% isoflurane (the Iso2 group) and 50% O2 alone (the control group) for 3 h, respectively...
  43. Herraiz C, Olivares C, Castejón Griñán M, Abrisqueta M, Jiménez Cervantes C, García Borrón J. Functional Characterization of MC1R-TUBB3 Intergenic Splice Variants of the Human Melanocortin 1 Receptor. PLoS ONE. 2015;10:e0144757 pubmed publisher
    ..Intergenic splicing produces two MC1R isoforms, designated Iso1 and Iso2, bearing the complete seven transmembrane helices from MC1R fused to TUBB3-derived C-terminal extensions, ..
  44. Sponder G, Mastrototaro L, Kurth K, Merolle L, Zhang Z, Abdulhanan N, et al. Human CNNM2 is not a Mg(2+) transporter per se. Pflugers Arch. 2016;468:1223-40 pubmed publisher
    ..the following: (1) the transcription-responsiveness of CNNM2 to Mg starvation, (2) the cellular localization of Iso1 and Iso2, (3) the ability of Iso1 and Iso2 to transport Mg(2+), and (4) the complex-forming ability and spectra of ..
  45. Liu C, Lu R, Guo G, He T, Li Y, Xu H, et al. Transcriptome analysis reveals translational regulation in barley microspore-derived embryogenic callus under salt stress. Plant Cell Rep. 2016;35:1719-28 pubmed publisher
    ..real-time polymerase chain reaction validation showed that the genes related to translation regulation (such as eIF1A, RPLP0, RPLP2, VARS) were down-regulated to control general protein synthesis, and the genes related to ..
  46. Dmitriev S, Terenin I, Andreev D, Ivanov P, Dunaevsky J, Merrick W, et al. GTP-independent tRNA delivery to the ribosomal P-site by a novel eukaryotic translation factor. J Biol Chem. 2010;285:26779-87 pubmed publisher
    ..The corresponding gene is found in all eukaryotes and includes an SUI1 domain present also in translation initiation factor eIF1. The versatility of translation initiation strategies in eukaryotes is discussed.
  47. Hinnebusch A. Structural Insights into the Mechanism of Scanning and Start Codon Recognition in Eukaryotic Translation Initiation. Trends Biochem Sci. 2017;42:589-611 pubmed publisher
    ..ligands supports this model and illuminates the molecular functions of eukaryotic initiation factors eIF1, eIF1A, and eIF2 in restricting to AUG codons the transition to the closed conformation...
  48. Deshpande J, Sharma D, Saxena V, Shetty S, Qureshi T, Nalavade U. Genomic characterization of two new enterovirus types, EV-A114 and EV-A121. J Med Microbiol. 2016;65:1465-1471 pubmed publisher
    ..In this paper we report identification and complete genome sequence analysis of these two isolates classified as EV-A114 and EV-A121.
  49. Lind C, Ã…qvist J. Principles of start codon recognition in eukaryotic translation initiation. Nucleic Acids Res. 2016;44:8425-32 pubmed publisher
    ..The two initiation factors eIF1 and eIF1A are known to provide important functions for the initiation process and codon selection...
  50. Chen H, Li L, Chen X, Yang M, Ye Y, Wang X, et al. The mechanism of Jurkat cells apoptosis induced by Aggregatibacter actinomycetemcomitans cytolethal distending toxin. Apoptosis. 2017;22:841-851 pubmed publisher
    ..proteins were expressed differentially, among which 10 proteins (SMNDC1, TNFRSF10B, UBE2I, ITM2A, CASP3, P53, EIF1, TCF3, HMGN5, CASP8) were up-regulated and 7 proteins (RRM2, TPX2, KIF11, NUCKS1, TOP2A, XRCC1, PTPLAD1, RRM2) were ..
  51. Auler P, Benitez L, do Amaral M, Vighi I, Rodrigues G, da Maia L, et al. Selection of candidate reference genes and validation for real-time PCR studies in rice plants exposed to low temperatures. Genet Mol Res. 2017;16: pubmed publisher
    ..The validation with the antioxidant system genes SODCc1-Cu/Zn, CATC, APX2, and GR2 confirmed the importance of using previously tested normalizing genes for adequate real-time PCR results. ..
  52. Rahman R, Chirn G, Kanodia A, Sytnikova Y, Brembs B, Bergman C, et al. Unique transposon landscapes are pervasive across Drosophila melanogaster genomes. Nucleic Acids Res. 2015;43:10655-72 pubmed publisher
    ..across cell lines and fly strains, even for identically named sub-strains from different laboratories such as the ISO1 strain used for the reference genome sequence...
  53. Krstic M, MacMillan C, Leong H, Clifford A, Souter L, Dales D, et al. The transcriptional regulator TBX3 promotes progression from non-invasive to invasive breast cancer. BMC Cancer. 2016;16:671 pubmed publisher
    ..Array profiling of the 21NT TBX3 iso1 and iso2 transfectants showed that there are common alterations in expression of several genes involved in signal ..
  54. Loughran G, Firth A, Atkins J, Ivanov I. Translational autoregulation of BZW1 and BZW2 expression by modulating the stringency of start codon selection. PLoS ONE. 2018;13:e0192648 pubmed publisher
    ..The levels of eukaryotic translation initiation factors 1 (eIF1) and 5 (eIF5) play critical roles in controlling the stringency of translation start site selection...
  55. Wang S, Tao P, Hu H, Yuan J, Zhao L, Sun B, et al. Effects of initiating time and dosage of Panax notoginseng on mucosal microvascular injury in experimental colitis. World J Gastroenterol. 2017;23:8308-8320 pubmed publisher
    ..The serum concentrations of cytokines, including vascular endothelial growth factor (VEGF)A121, VEGFA165, interleukin (IL)-4, IL-6, IL-10 and tumor necrosis factor (TNF)-?, were detected by enzyme-linked ..
  56. Zhou L, Cui P, Zhao S, Ye T, Li Y, Peng J, et al. Differential function and regulation of orphan nuclear receptor TR3 isoforms in endothelial cells. Tumour Biol. 2016;37:3307-20 pubmed publisher
    ..TR3 transcript variant 1 (TR3-TV1) and variant 2 (TR3-TV2) encoding the same TR3 isoform 1 protein (TR3-iso1) that was named TR3 has been extensively studied...
  57. Llácer J, Hussain T, Marler L, Aitken C, Thakur A, Lorsch J, et al. Conformational Differences between Open and Closed States of the Eukaryotic Translation Initiation Complex. Mol Cell. 2015;59:399-412 pubmed publisher
    ..eukaryotes begins with the formation of a pre-initiation complex (PIC) containing the 40S ribosomal subunit, eIF1, eIF1A, eIF3, ternary complex (eIF2-GTP-Met-tRNAi), and eIF5...
  58. Stewart J, Cowan J, Perry L, Coldwell M, Proud C. ABC50 mutants modify translation start codon selection. Biochem J. 2015;467:217-29 pubmed publisher
    ..It is widely accepted that the presence and movement of eIF1, eIF1A and eIF5 are key factors in modulating the stringency of start-site selection, which normally requires an AUG ..
  59. Sokabe M, Fraser C. Human eukaryotic initiation factor 2 (eIF2)-GTP-Met-tRNAi ternary complex and eIF3 stabilize the 43 S preinitiation complex. J Biol Chem. 2014;289:31827-36 pubmed publisher
    ..However, the contributions of eIF1, eIF1A, eIF3, and the eIF2-GTP-Met-tRNAi ternary complex (TC) in stabilizing the 43 S PIC are poorly defined...
  60. Lian Z, Pan J, Liu J, Zhang S, Zhu M, Arbuthnot P, et al. The translation initiation factor, hu-Sui1 may be a target of hepatitis B X antigen in hepatocarcinogenesis. Oncogene. 1999;18:1677-87 pubmed
    ..One differentially expressed gene, the human homolog of sui1 (hu-sui1), encodes a translation initiation factor whose expression was suppressed by X antigen in HepG2 cells...
  61. Chi D, Zeng Y, Xu M, Si L, Qu X, Liu H, et al. LC3-Dependent Autophagy in Pig 2-Cell Cloned Embryos Could Influence the Degradation of Maternal mRNA and the Regulation of Epigenetic Modification. Cell Reprogram. 2017;: pubmed publisher
    ..05 or p?<?0.01), but a significantly lower level of LC3, Sox2, and eIF1A was observed at 4-cell stage (p?<?0.05), compared with PA embryos...
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    ..4-Å resolution. One domain has the fold similar to that of eIF1, which is crucial for the scanning and initiation codon selection...
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    ..Key roles in the accuracy of initiation codon selection belong to eIF1 and eIF1A, whereas the mammalian-specific DHX29 helicase substantially contributes to ribosomal scanning of structured mRNAs...
  64. Bohnsack M, Regener K, Schwappach B, Saffrich R, Paraskeva E, Hartmann E, et al. Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm. EMBO J. 2002;21:6205-15 pubmed
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  65. Davidi L, Pick U. Novel 9-cis/all-trans ?-carotene isomerases from plastidic oil bodies in Dunaliella bardawil catalyze the conversion of all-trans to 9-cis ?-carotene. Plant Cell Rep. 2017;36:807-814 pubmed publisher
    ..The expression of the corresponding genes, 9-cis-?C-iso1 and 9-cis-?C-iso2, is enhanced under light stress...
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    ..Interactions among translation initiation factors, including eIF1 and eIF5, govern start codon selection...
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    To investigate the immunogenicity of Homo sapiens putative translation initiation factor (Sui1) in hepatocellular carcinoma (HCC), enzyme-linked immunosorbent assay (ELISA) and Western blot were utilized to assess autoantibody responses ..
  68. Dong J, Lai R, Nielsen K, Fekete C, Qiu H, Hinnebusch A. The essential ATP-binding cassette protein RLI1 functions in translation by promoting preinitiation complex assembly. J Biol Chem. 2004;279:42157-68 pubmed
    ..There was also a marked reduction in 40 S-bound eIF2 and eIF1, consistent with an important role for RLI1 in assembly of 43 S preinitiation complexes in vivo...
  69. Pisarev A, Skabkin M, Pisareva V, Skabkina O, Rakotondrafara A, Hentze M, et al. The role of ABCE1 in eukaryotic posttermination ribosomal recycling. Mol Cell. 2010;37:196-210 pubmed publisher
    ..recycling of eukaryotic posttermination complexes (post-TCs) can be mediated by initiation factors eIF3, eIF1, and eIF1A (Pisarev et al...
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    ..C-terminal domain of DENR on the ribosome has a striking similarity with those of canonical initiation factor 1 (eIF1), which controls the fidelity of translation initiation and scanning...
  71. Sheikh M, Fernandez Salas E, Yu M, Hussain A, Dinman J, Peltz S, et al. Cloning and characterization of a human genotoxic and endoplasmic reticulum stress-inducible cDNA that encodes translation initiation factor 1(eIF1(A121/SUI1)). J Biol Chem. 1999;274:16487-93 pubmed
    ..7 kDa. The deduced amino acid sequence of A121 shows high homology to the yeast translation initiation factor (eIF) sui1 and also exhibits perfect identity to the partial sequence of recently purified human eIF1...
  72. Sinvani H, Haimov O, Svitkin Y, Sonenberg N, Tamarkin Ben Harush A, Viollet B, et al. Translational tolerance of mitochondrial genes to metabolic energy stress involves TISU and eIF1-eIF4GI cooperation in start codon selection. Cell Metab. 2015;21:479-92 pubmed publisher
    ..Purified 48S preinitiation complex is sufficient for initiation via TISU AUG, when preceded by a short 5' UTR. eIF1 stimulates TISU but inhibits non-TISU-directed initiation...
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    ..We further show that eIF3 subunits a and c interact with initiation factors eIF1 and eIF1A, which control the stringency of start codon selection...
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    ..Differential display is effective for identifying genes associated with apoptosis. Novel genes may be identified by further analysis of the gene fragments identified in this study. The function of O48 is unknown. ..
  75. Mendell J, Medghalchi S, Lake R, Noensie E, Dietz H. Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes. Mol Cell Biol. 2000;20:8944-57 pubmed
    ..using the two-hybrid system, we obtained evidence for direct interaction between rent2 and human eIF4AI and Sui1, both components of the translation initiation complex...
  76. Fields C, Adams M. Expressed sequence tags identify a human isolog of the suil translation initiation factor. Biochem Biophys Res Commun. 1994;198:288-91 pubmed
    ..The identification of suilisol illustrates the utility of assemblies of independent ESTs for deriving full-length cDNA sequences for new human genes. ..
  77. Volante A, Desiderio F, Tondelli A, Perrini R, Orasen G, Biselli C, et al. Genome-Wide Analysis of japonica Rice Performance under Limited Water and Permanent Flooding Conditions. Front Plant Sci. 2017;8:1862 pubmed publisher
    ..Among these, three (OsOFP2, Dlf1, OsMADS56) and seven (SUI1, Sd1, OsCOL4, Nal1, OsphyB, GW5, Ehd1) candidate genes were, respectively, identified to co-localize with LW-..
  78. Nanda J, Saini A, Munoz A, Hinnebusch A, Lorsch J. Coordinated movements of eukaryotic translation initiation factors eIF1, eIF1A, and eIF5 trigger phosphate release from eIF2 in response to start codon recognition by the ribosomal preinitiation complex. J Biol Chem. 2013;288:5316-29 pubmed publisher
    ..Here, we provide evidence that the C-terminal tail (CTT) of eIF1A, which we previously implicated in start codon recognition, moves closer to the N-terminal domain of eIF5 when the ..
  79. Luna R, Arthanari H, Hiraishi H, Nanda J, Martin Marcos P, Markus M, et al. The C-terminal domain of eukaryotic initiation factor 5 promotes start codon recognition by its dynamic interplay with eIF1 and eIF2β. Cell Rep. 2012;1:689-702 pubmed publisher
    ..essential for protein synthesis, which requires scanning and involves eukaryotic initiation factors (eIFs) eIF1, eIF1A, eIF2, and eIF5...
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    ..eIF2, eIF3, eIF1 and eIF1A promote efficient 48S initiation complex formation at AUG828, which is reduced ∼5-fold on omission of eIF1 ..
  81. Obayashi E, Luna R, Nagata T, Martin Marcos P, Hiraishi H, Singh C, et al. Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5. Cell Rep. 2017;18:2651-2663 pubmed publisher
    ..initiation, eIF3 binds the solvent-accessible side of the 40S ribosome and recruits the gate-keeper protein eIF1 and eIF5 to the decoding center...
  82. Fletcher C, Pestova T, Hellen C, Wagner G. Structure and interactions of the translation initiation factor eIF1. EMBO J. 1999;18:2631-7 pubmed
    b>eIF1 is a universally conserved translation factor that is necessary for scanning and involved in initiation site selection. We have determined the solution structure of human eIF1 with an N-terminal His tag using NMR spectroscopy...
  83. Yi T, Arthanari H, Akabayov B, Song H, Papadopoulos E, Qi H, et al. eIF1A augments Ago2-mediated Dicer-independent miRNA biogenesis and RNA interference. Nat Commun. 2015;6:7194 pubmed publisher
    ..Here we report that translation initiation factor eIF1A directly interacts with Ago2 and promotes Ago2 activities in RNAi and miR-451 biogenesis...
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    ..The unstructured N-terminal tail (NTT) of yeast eIF1A deploys five basic residues to contact tRNAi, mRNA, or 18S rRNA exclusively in the closed state...