Gene Symbol: EID3
Description: EP300 interacting inhibitor of differentiation 3
Alias: NS4EB, NSE4B, NSMCE4B, EP300-interacting inhibitor of differentiation 3, E1A-like inhibitor of differentiation 3, EID-1-like inhibitor of differentiation 3, EID-3, non-SMC element 4 homolog B, non-structural maintenance of chromosomes element 4 homolog B, testis tissue sperm-binding protein Li 96mP
Neguembor M, Xynos A, Onorati M, Caccia R, Bortolanza S, Godio C, et al
. FSHD muscular dystrophy region gene 1 binds Suv4-20h1 histone methyltransferase and impairs myogenesis. J Mol Cell Biol. 2013;5:294-307 pubmed publisher
..Moreover, Suv4-20h KO mice develop muscular dystrophy signs. Finally, we identify the FRG1/Suv4-20h1 target Eid3 as a novel myogenic inhibitor that contributes to the muscle differentiation defects...
Wang Y, Wang Y, Liu S, Liu Y, Xu H, Liang J, et al
. Upregulation of EID3 sensitizes breast cancer cells to ionizing radiation-induced cellular senescence. Biomed Pharmacother. 2018;107:606-614 pubmed publisher
..Since the expression of E1A-like inhibitor of differentiation 3 (EID3) was highly upregulated in MCF-7 cells after BMS treatment, we investigated the role of EID3 in the response of MCF-..
Munakata K, Uemura M, Tanaka S, Kawai K, Kitahara T, Miyo M, et al
. Cancer Stem-like Properties in Colorectal Cancer Cells with Low Proteasome Activity. Clin Cancer Res. 2016;22:5277-5286 pubmed
..Microarray analysis revealed that the expression of EP300-interacting inhibitor of differentiation 3 (EID3) was significantly increased in LPACs...
Hu B, Liao C, Millson S, Mollapour M, Prodromou C, Pearl L, et al
. Qri2/Nse4, a component of the essential Smc5/6 DNA repair complex. Mol Microbiol. 2005;55:1735-50 pubmed
..This could imply a role for Nse4 in maintenance of higher order chromosome structure...
Båvner A, Matthews J, Sanyal S, Gustafsson J, Treuter E. EID3 is a novel EID family member and an inhibitor of CBP-dependent co-activation. Nucleic Acids Res. 2005;33:3561-9 pubmed
..Here, we describe a third family member designated EID3 that is highly expressed in testis and shows homology to a region of EID1 implicated in binding to CBP/p300...
Taylor E, Copsey A, Hudson J, Vidot S, Lehmann A. Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex. Mol Cell Biol. 2008;28:1197-206 pubmed
..Depletion also confers sensitivity to methyl methanesulfonate. Several of the components are modified by sumoylation and ubiquitination. ..
Ji Y, Schaid D, Desta Z, Kubo M, Batzler A, Snyder K, et al
. Citalopram and escitalopram plasma drug and metabolite concentrations: genome-wide associations. Br J Clin Pharmacol. 2014;78:373-83 pubmed publisher
Sasajima Y, Tanaka H, Miyake S, Yuasa Y. A novel EID family member, EID-3, inhibits differentiation and forms a homodimer or heterodimer with EID-2. Biochem Biophys Res Commun. 2005;333:969-75 pubmed
..EID-3 formed a homodimer or heterodimer with EID-2. These results suggest that EID-3 inhibits differentiation by blocking transcription as a complex in cells. ..
Kozakova L, Vondrova L, Stejskal K, Charalabous P, Kolesar P, Lehmann A, et al
. The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex. Cell Cycle. 2015;14:920-30 pubmed publisher
..These results suggest that MAGEA1 functions as a co-factor of TRIM31 ubiquitin-ligase and that the TRIM31-MAGEA1-NSE4 complex may have evolved from an ancestral NSE1-NSE3-NSE4 complex. ..