Gene Symbol: EID 2
Description: EP300 interacting inhibitor of differentiation 2
Alias: CRI2, EID-2, EP300-interacting inhibitor of differentiation 2, CREBBP/EP300 inhibitor 2, CREBBP/EP300 inhibitory protein 2, E1A like inhibitor of differentiation 2, EID-1-like inhibitor of differentiation 2
Species: human
Products:     EID 2

Top Publications

  1. Andrianopoulos V, Celli B, Franssen F, Pinto Plata V, Calverley P, Vanfleteren L, et al. Determinants of exercise-induced oxygen desaturation including pulmonary emphysema in COPD: Results from the ECLIPSE study. Respir Med. 2016;119:87-95 pubmed publisher
    ..Patients with EID in GOLD stage II have higher odds to have moderate or worse emphysema compared those with EID in GOLD stage III-IV. Emphysematous patients with high ADO-score should be monitored for EID. ..
  2. Miyake S, Yanagisawa Y, Yuasa Y. A novel EID-1 family member, EID-2, associates with histone deacetylases and inhibits muscle differentiation. J Biol Chem. 2003;278:17060-5 pubmed
    ..These results indicate a new family of differentiation inhibitors, although there are several differences in the biochemical mechanisms between EID-2 and EID-1. ..
  3. Ji A, Dao D, Chen J, MacLellan W. EID-2, a novel member of the EID family of p300-binding proteins inhibits transactivation by MyoD. Gene. 2003;318:35-43 pubmed
    ..These data suggest that EID-1 and -2 represent a novel family of proteins that negatively regulate differentiation through a p300-dependent mechanism. ..
  4. Sasajima Y, Tanaka H, Miyake S, Yuasa Y. A novel EID family member, EID-3, inhibits differentiation and forms a homodimer or heterodimer with EID-2. Biochem Biophys Res Commun. 2005;333:969-75 pubmed
    ..EID-3 formed a homodimer or heterodimer with EID-2. These results suggest that EID-3 inhibits differentiation by blocking transcription as a complex in cells. ..
  5. Zhang C, Li X, Adelmant G, Dobbins J, Geisen C, Oser M, et al. Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21. Proc Natl Acad Sci U S A. 2015;112:15372-7 pubmed publisher
  6. Lee H, Lee J, Miyake S, Kim S. A novel E1A-like inhibitor of differentiation (EID) family member, EID-2, suppresses transforming growth factor (TGF)-beta signaling by blocking TGF-beta-induced formation of Smad3-Smad4 complexes. J Biol Chem. 2004;279:2666-72 pubmed
    ..These results suggest that EID-2 may function as an endogenous suppressor of TGF-beta signaling. ..