EHMT1

Summary

Gene Symbol: EHMT1
Description: euchromatic histone lysine methyltransferase 1
Alias: EHMT1-IT1, EUHMTASE1, Eu-HMTase1, FP13812, GLP, GLP1, KLEFS1, KMT1D, histone-lysine N-methyltransferase EHMT1, EHMT1 intronic transcript 1, G9a-like protein 1, H3-K9-HMTase 5, euchromatic histone-lysine N-methyltransferase 1, histone H3-K9 methyltransferase 5, histone-lysine N-methyltransferase, H3 lysine-9 specific 5, lysine N-methyltransferase 1D
Species: human
Products:     EHMT1

Top Publications

  1. de Vogel S, Wouters K, Gottschalk R, Van Schooten F, de Goeij A, De Bruine A, et al. Genetic variants of methyl metabolizing enzymes and epigenetic regulators: associations with promoter CpG island hypermethylation in colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2009;18:3086-96 pubmed publisher
    ..folate metabolizing enzymes (MTHFR, MTR, and MTRR), DNA methyltransferase DNMT3b, and histone methyltransferases (EHMT1, EHMT2, and PRDM2), with colorectal cancers, with or without the CpG island methylator phenotype (CIMP), MLH1 ..
  2. Ogawa H, Ishiguro K, Gaubatz S, Livingston D, Nakatani Y. A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. Science. 2002;296:1132-6 pubmed
    ..The E2F-6 complex preferentially occupies target promoters in G0 cells rather than in G1 cells. These data suggest that these chromatin modifiers contribute to silencing of E2F- and Myc-responsive genes in quiescent cells. ..
  3. Collins R, Northrop J, Horton J, Lee D, Zhang X, Stallcup M, et al. The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules. Nat Struct Mol Biol. 2008;15:245-50 pubmed publisher
    ..G9a and G9a-like protein (GLP) are euchromatin-associated methyltransferases that repress transcription by mono- and dimethylating histone H3 at ..
  4. Kleefstra T, van Zelst Stams W, Nillesen W, Cormier Daire V, Houge G, Foulds N, et al. Further clinical and molecular delineation of the 9q subtelomeric deletion syndrome supports a major contribution of EHMT1 haploinsufficiency to the core phenotype. J Med Genet. 2009;46:598-606 pubmed publisher
    ..The syndrome can be either caused by a submicroscopic 9q34.3 deletion or by intragenic EHMT1 mutations leading to haploinsufficiency of the EHMT1 gene...
  5. Chang Y, Zhang X, Horton J, Upadhyay A, Spannhoff A, Liu J, et al. Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294. Nat Struct Mol Biol. 2009;16:312-7 pubmed publisher
    ..G9a and G9a-like protein (GLP) are euchromatin-associated methyltransferases that repress transcription by methylating histone H3 Lys9...
  6. Ea C, Hao S, Yeo K, Baltimore D. EHMT1 protein binds to nuclear factor-?B p50 and represses gene expression. J Biol Chem. 2012;287:31207-17 pubmed publisher
    ..Here, we report that a euchromatic H3K9 methyltransferase, EHMT1, functions as a negative regulator in both the NF-?B- and type I interferon-mediated gene induction pathways...
  7. Kleefstra T, Smidt M, Banning M, Oudakker A, Van Esch H, de Brouwer A, et al. Disruption of the gene Euchromatin Histone Methyl Transferase1 (Eu-HMTase1) is associated with the 9q34 subtelomeric deletion syndrome. J Med Genet. 2005;42:299-306 pubmed
    ..The expression pattern of this gene suggests a role in the CNS development and function, which is in line with the severe mental retardation and behaviour problems in patients who lack one copy of the gene. ..
  8. Schaefer A, Sampath S, Intrator A, Min A, Gertler T, Surmeier D, et al. Control of cognition and adaptive behavior by the GLP/G9a epigenetic suppressor complex. Neuron. 2009;64:678-91 pubmed publisher
    ..symptoms of the human 9q34 mental retardation syndrome that is associated with structural alterations of the GLP/EHMT1 gene...
  9. Chang Y, Sun L, Kokura K, Horton J, Fukuda M, Espejo A, et al. MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a. Nat Commun. 2011;2:533 pubmed publisher
    ..Here we show that G9a or G9a-like protein (GLP) dimethylate the amino-terminal lysine 44 (K44) of mouse Dnmt3a (equivalent to K47 of human DNMT3A) in vitro and in ..

More Information

Publications145 found, 100 shown here

  1. Dinda B, Dinda M, Kulsi G, Chakraborty A, Dinda S. Therapeutic potentials of plant iridoids in Alzheimer's and Parkinson's diseases: A review. Eur J Med Chem. 2019;169:185-199 pubmed publisher
    ..improved the expressions of neuroprotective proteins, Bcl-2 via activations of growth-related protein-1 receptor (GLP-1R), PKC, MEK, MAPK/PI3K, and AMPK, and suppressed the expressions of pro-apoptotic proteins, Bax and caspase-3...
  2. Fowler S. Low-calorie sweetener use and energy balance: Results from experimental studies in animals, and large-scale prospective studies in humans. Physiol Behav. 2016;164:517-523 pubmed publisher
    ..food consumption, lower post-prandial thermogenesis, increased weight gain, greater percent body fat, decreased GLP-1 release during glucose tolerance testing, and significantly greater fasting glucose, glucose area under the curve ..
  3. Jiang Y, Zhang W, Xu S, Lin H, Sui W, Liu H, et al. Transplantation of human fetal pancreatic progenitor cells ameliorates renal injury in streptozotocin-induced diabetic nephropathy. J Transl Med. 2017;15:147 pubmed publisher
    ..by suspension culture after a differentiation of progenitor cells in medium containing glucagon-like peptide-1 (Glp-1) and nicotinamide. Then islets were transplanted into the liver of diabetic rats via portal vein...
  4. Jiang Y, Chang G, Wang Y, Zhang D, Cao L, Liu J. Geniposide Prevents Hypoxia/Reoxygenation-Induced Apoptosis in H9c2 Cells: Improvement of Mitochondrial Dysfunction and Activation of GLP-1R and the PI3K/AKT Signaling Pathway. Cell Physiol Biochem. 2016;39:407-21 pubmed publisher
    ..Our results suggest that geniposide pretreatment inhibits H/R-induced myocardial apoptosis by reversing mitochondrial dysfunction, an effect in part due to activation of GLP-1R and PI3K/AKT signaling pathway.
  5. Abdel Latif R, Heeba G, Taye A, Khalifa M. Lixisenatide, a novel GLP-1 analog, protects against cerebral ischemia/reperfusion injury in diabetic rats. Naunyn Schmiedebergs Arch Pharmacol. 2018;391:705-717 pubmed publisher
    ..Lixisenatide is a glucagon like peptide-1 (GLP-1) analog that is recently used for T2DM treatment with established neuroprotective properties...
  6. Cam M, Hazar Yavuz A, Yıldız S, Ertaş B, Ayaz Adakul B, Taskın T, et al. The methanolic extract of Thymus praecox subsp. skorpilii var. skorpilii restores glucose homeostasis, ameliorates insulin resistance and improves pancreatic β-cell function on streptozotocin/nicotinamide-induced type 2 diabetic rats. J Ethnopharmacol. 2019;231:29-38 pubmed publisher
    ..protein kinase (AMPK), peroxisome proliferator-activated receptor gamma (PPAR-γ) and glucagon like peptide-1 (GLP-1). Histopathological alterations of the pancreas were examined...
  7. Silver B, Ramaiya K, Andrew S, Fredrick O, Bajaj S, Kalra S, et al. EADSG Guidelines: Insulin Therapy in Diabetes. Diabetes Ther. 2018;9:449-492 pubmed publisher
    ..insulin or twice-daily premixed insulin, alone or in combination with glucagon-like peptide-1 receptor agonist (GLP-1 RA) or in combination with other oral antidiabetic drugs (OADs) (B)...
  8. Lampropoulou E, Lymperopoulou A, Charonis A. Reduced expression of ERp46 under diabetic conditions in β-cells and the effect of liraglutide. Metabolism. 2016;65:7-15 pubmed publisher
    ..In addition, the involvement of incretin hormone glucagon-like peptide 1 (GLP-1) in diabetes proposes that incretin-mimetic compounds may be among the optimal choices in future therapeutic ..
  9. Manaer T, Yu L, Zhang Y, Xiao X, Nabi X. Anti-diabetic effects of shubat in type 2 diabetic rats induced by combination of high-glucose-fat diet and low-dose streptozotocin. J Ethnopharmacol. 2015;169:269-74 pubmed publisher
    ..serum creatinine (SCr), blood urea nitrogen (BUN), C-peptide, glycated hemoglobin (HbAlc), glucagon-like peptide-1 (GLP-1) levels and pancreas tissue sections were tested after 4 weeks...
  10. Elkind Hirsch K, Paterson M, Shaler D, Gutowski H. SHORT-TERM SITAGLIPTIN-METFORMIN THERAPY IS MORE EFFECTIVE THAN METFORMIN OR PLACEBO IN PRIOR GESTATIONAL DIABETIC WOMEN WITH IMPAIRED GLUCOSE REGULATION. Endocr Pract. 2018;24:361-368 pubmed publisher
    ..DPP-4i = dipeptidyl peptidase 4 inhibitor; FBG = fasting blood glucose; GDM = gestational diabetes mellitus; GLP-1 = glucagon-like peptide 1; HDL-C = high-density-lipoprotein cholesterol; HOMA-IR = homeostasis model assessment ..
  11. Lima G, Vuolo M, Batista A, Dragano N, Solon C, Maróstica Júnior M. Passiflora edulis peel intake improves insulin sensitivity, increasing incretins and hypothalamic satietogenic neuropeptide in rats on a high-fat diet. Nutrition. 2016;32:863-70 pubmed publisher
    ..01), glucose-dependent insulinotropic polypeptide (P < 0.01), and glucagon-like peptide-1 (GLP-1) (P < 0...
  12. Abdelwahed O, Tork O, Gamal El Din M, Rashed L, Zickri M. Effect of glucagon-like peptide-1 analogue; Exendin-4, on cognitive functions in type 2 diabetes mellitus; possible modulation of brain derived neurotrophic factor and brain Visfatin. Brain Res Bull. 2018;139:67-80 pubmed publisher
    ..to study the changes in cognitive functions in T2DM, either not treated or treated with Glucagon-like peptide 1 (GLP-1) analogue: Ex-4, and to identify the possible underlying mechanisms of these changes and whether BDNF and brain ..
  13. Balakumar M, Prabhu D, Sathishkumar C, Prabu P, Rokana N, Kumar R, et al. Improvement in glucose tolerance and insulin sensitivity by probiotic strains of Indian gut origin in high-fat diet-fed C57BL/6J mice. Eur J Nutr. 2018;57:279-295 pubmed publisher
    ..Biochemical markers, glucose tolerance, insulin resistance, and GLP-1 and LPS levels were assessed by standard protocols. Gut integrity was measured by intestinal permeability test...
  14. Dalle S, Quoyer J, Varin E, Costes S. Roles and regulation of the transcription factor CREB in pancreatic β -cells. Curr Mol Pharmacol. 2011;4:187-95 pubmed
    ..in response to a diverse array of stimuli including glucose, incretin hormones such as the glucagon-like peptide-1 (GLP-1) or the gastric inhibitory polypeptide (GIP), the pituitary adenylate cyclase-activating polypeptide (PACAP), or ..
  15. Zhou S, Bai L, Lv L, Chen R, Li C, Liu X, et al. Liraglutide ameliorates renal injury in streptozotocin‑induced diabetic rats by activating endothelial nitric oxide synthase activity via the downregulation of the nuclear factor‑κB pathway. Mol Med Rep. 2014;10:2587-94 pubmed publisher
    Accumulating evidence has implicated that liraglutide, one of the human glucagon‑like peptide‑1 (GLP‑1) analogues, elicits protective effects on diabetic nephropathy; however, the mechanism has yet to be fully ..
  16. Carrera Boada C, Martínez Moreno J. Pathophysiology of diabetes mellitus type 2: beyond the duo "insulin resistance-secretion deficit". Nutr Hosp. 2013;28 Suppl 2:78-87 pubmed publisher
    ..consider the changes observed in incretins profiles like GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide 1) directly related to glucose homeostasis maintenance...
  17. Diz Chaves Y, Toba L, Fandino J, González Matías L, Garcia Segura L, Mallo F. The GLP-1 analog, liraglutide prevents the increase of proinflammatory mediators in the hippocampus of male rat pups submitted to maternal perinatal food restriction. J Neuroinflammation. 2018;15:337 pubmed publisher
    ..We studied the effect of Glucagon-like peptide-1 receptor (GLP-1R) agonists, liraglutide, which have very potent metabolic and neuroprotective effects, in order to ameliorate/..
  18. He J, Wang C, Sun Y, Lu B, Cui J, Dong N, et al. Exendin-4 protects bone marrow-derived mesenchymal stem cells against oxygen/glucose and serum deprivation-induced apoptosis through the activation of the cAMP/PKA signaling pathway and the attenuation of ER stress. Int J Mol Med. 2016;37:889-900 pubmed publisher
    Exendin-4 (ex-4) is a long-acting glucagon-like peptide-1 receptor (GLP-1R) agonist which exerts beneficial effects on glycemic control and promotes cell viability...
  19. Kieć Klimczak M, Malczewska Malec M, Razny U, Zdzienicka A, Gruca A, Goralska J, et al. Assessment of incretins in oral glucose and lipid tolerance tests may be indicative in the diagnosis of metabolic syndrome aggravation. J Physiol Pharmacol. 2016;67:217-26 pubmed
    ..Recently it has however been suggested that glucagon-like peptide-1 (GLP-1) is putative early biomarker of metabolic consequences of the obesity associated proinflammatory state...
  20. Nilsson A, Johansson Boll E, Sandberg J, Björck I. Gut microbiota mediated benefits of barley kernel products on metabolism, gut hormones, and inflammatory markers as affected by co-ingestion of commercially available probiotics: a randomized controlled study in healthy subjects. Clin Nutr ESPEN. 2016;15:49-56 pubmed publisher
    ..PAI-1), and concentrations of gut derived hormones involved in satiety and glucose homeostasis (plasma (p-) PYY, p-GLP-1) and intestinal barrier integrity (p-GLP-2). Breath hydrogen was determined as a marker of colonic fermentation...
  21. Qin Y, Chen M, Yang Y, Zhou X, Shao S, Wang D, et al. Liraglutide improves hepatic insulin resistance via the canonical Wnt signaling pathway. Mol Med Rep. 2018;17:7372-7380 pubmed publisher
    Liraglutide, a modified form of glucagon?like peptide?1 (GLP?1), is used in the treatment of diabetes mellitus. However, the underlying mechanism by which liraglutide improves liver insulin resistance remains to be elucidated...
  22. Simeone P, Liani R, Tripaldi R, Di Castelnuovo A, Guagnano M, Tartaro A, et al. Thromboxane-Dependent Platelet Activation in Obese Subjects with Prediabetes or Early Type 2 Diabetes: Effects of Liraglutide- or Lifestyle Changes-Induced Weight Loss. Nutrients. 2018;10: pubmed publisher
    ..subjects with prediabetes or newly-diagnosed T2DM were randomized to the glucagon-like peptide receptor agonist (GLP-RA) liraglutide (1...
  23. Chen F, Wang W, Ding H, Yang Q, Dong Q, Cui M. The glucagon-like peptide-1 receptor agonist exendin-4 ameliorates warfarin-associated hemorrhagic transformation after cerebral ischemia. J Neuroinflammation. 2016;13:204 pubmed publisher
    ..While the glucagon-like peptide-1 receptor (GLP-1R) agonist exendin-4 (Ex-4) is known to protect against oxidative stress and neuronal cell death caused by ..
  24. Thomson E, Pilon S, Guénette J, Williams A, Holloway A. Ozone modifies the metabolic and endocrine response to glucose: Reproduction of effects with the stress hormone corticosterone. Toxicol Appl Pharmacol. 2018;342:31-38 pubmed publisher
    ..on glucose tolerance and on the metabolic (triglyceride), endocrine/energy regulation (insulin, glucagon, GLP-1, leptin, ghrelin, corticosterone), and inflammatory/endothelial (TNF, IL-6, VEGF, PAI-1) response to exogenous ..
  25. Zac Varghese S, Trapp S, Richards P, Sayers S, Sun G, Bloom S, et al. The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage in mice. Dis Model Mech. 2014;7:1275-86 pubmed publisher
    ..homeostasis and the regulation of appetite through the secretion of gut hormones such as glucagon-like peptide-1 (GLP-1) and peptide tyrosine tyrosine (PYY)...
  26. Gault V, Lennox R, Flatt P. Sitagliptin, a dipeptidyl peptidase-4 inhibitor, improves recognition memory, oxidative stress and hippocampal neurogenesis and upregulates key genes involved in cognitive decline. Diabetes Obes Metab. 2015;17:403-13 pubmed publisher
    ..effects were associated with significant upregulation of hippocampal gene expression of glucagon-like peptide-1 (GLP-1) receptor, glucose-dependent insulinotropic polypeptide receptor, synaptophysin, sirtuin 1, glycogen synthase ..
  27. Bohl M, Bjørnshave A, Rasmussen K, Schioldan A, Amer B, Larsen M, et al. Dairy proteins, dairy lipids, and postprandial lipemia in persons with abdominal obesity (DairyHealth): a 12-wk, randomized, parallel-controlled, double-blinded, diet intervention study. Am J Clin Nutr. 2015;101:870-8 pubmed publisher
    ..chylomicrons of intestinal origin), free fatty acids (FFAs), insulin, glucose, glucagon, glucagon-like peptide 1 (GLP-1), and gastric inhibitory polypeptide (GIP)...
  28. Hyltén Cavallius L, Iepsen E, Wewer Albrechtsen N, Svendstrup M, Lubberding A, Hartmann B, et al. Patients With Long-QT Syndrome Caused by Impaired hERG-Encoded Kv11.1 Potassium Channel Have Exaggerated Endocrine Pancreatic and Incretin Function Associated With Reactive Hypoglycemia. Circulation. 2017;135:1705-1719 pubmed publisher
    ..and ? cells and intestinal L and K cells, secreting glucagon, insulin, and the incretins glucagon-like peptide-1 (GLP-1) and GIP (glucose-dependent insulinotropic polypeptide), respectively...
  29. Kessler L, Abely M. [Pancreatic infringement exocrine and endocrine in cystic fibrosis]. Arch Pediatr. 2016;23:12S21-12S32 pubmed publisher
    ..secretion, an insulin resistance secondary to chronic infection, and a decrease in the production of the GIP and GLP-1...
  30. Zanzer Y, Plaza M, Dougkas A, Turner C, Ostman E. Black pepper-based beverage induced appetite-suppressing effects without altering postprandial glycaemia, gut and thyroid hormones or gastrointestinal well-being: a randomized crossover study in healthy subjects. Food Funct. 2018;9:2774-2786 pubmed publisher
    ..In contrast, there were no changes in gut (peptide tyrosine-tyrosine [PYY] and glucagon-like peptide-1 [GLP-1]) and thyroid (triiodothyronine [T3] and thyroxine [T4]) hormones after BPB compared to the control beverage...
  31. Frederiksen T, Sønderby P, Ryberg L, Harris P, Bukrinski J, Scharff Poulsen A, et al. Oligomerization of a Glucagon-like Peptide 1 Analog: Bridging Experiment and Simulations. Biophys J. 2015;109:1202-13 pubmed publisher
    The glucagon-like peptide 1 (GLP-1) analog, liraglutide, is a GLP-1 agonist and is used in the treatment of type-2 diabetes mellitus and obesity...
  32. Li Y, Wu K, Yu S, Tamargo I, Wang Y, Greig N. Neurotrophic and neuroprotective effects of oxyntomodulin in neuronal cells and a rat model of stroke. Exp Neurol. 2017;288:104-113 pubmed publisher
    Proglucagon-derived peptides, especially glucagon-like peptide-1 (GLP-1) and its long-acting mimetics, have exhibited neuroprotective effects in animal models of stroke. Several of these peptides are in clinical trials for stroke...
  33. Gil A, Irache J, Penuelas I, Gonzalez Navarro C, López de Ceráin A. Toxicity and biodistribution of orally administered casein nanoparticles. Food Chem Toxicol. 2017;106:477-486 pubmed publisher
    ..through a 90 days dose-repeated toxicity study (OECD guideline 408), that was performed in Wistar rats under GLP conditions...
  34. Ahmed A, Gros P, Kuhn O, Leinweber P. Molecular level investigation of the role of peptide interactions in the glyphosate analytics. Chemosphere. 2018;196:129-134 pubmed publisher
    The detection of the herbicide glyphosate (GLP) in environmental samples is most often conducted after derivatizing the target molecule with the chromophore 9-fluorenylmethyloxycarbonyl chloride (FMOC-Cl)...
  35. Harnedy P, Parthsarathy V, McLaughlin C, O Keeffe M, Allsopp P, McSorley E, et al. Atlantic salmon (Salmo salar) co-product-derived protein hydrolysates: A source of antidiabetic peptides. Food Res Int. 2018;106:598-606 pubmed publisher
    ..4L and Flavourzyme 500L exhibited significantly higher (p < 0.001) insulin and GLP-1 secretory activity from pancreatic BRIN-BD11 and enteroendocrine GLUTag cells, respectively, when tested at 2...
  36. Fadini G, Albiero M, Avogaro A. Direct effects of DPP-4 inhibition on the vasculature. Reconciling basic evidence with lack of clinical evidence. Vascul Pharmacol. 2015;73:1-3 pubmed publisher
    ..peptidase-4 inhibitors (DPP-4i) lower blood glucose by protecting the incretin hormone glucagon-like peptide-1 (GLP-1) from enzymatic degradation, thereby restoring meal-stimulated insulin release...
  37. Honda K. Glucagon-related peptides and the regulation of food intake in chickens. Anim Sci J. 2016;87:1090-8 pubmed publisher
    ..proglucagon processing: glucagon is produced in the pancreas, whereas oxyntomodulin (OXM), glucagon-like peptide (GLP)-1 and GLP-2 are produced in the intestine and brain...
  38. Tian X, Zhang H, Sannerud J, Xing J. Achieving diverse and monoallelic olfactory receptor selection through dual-objective optimization design. Proc Natl Acad Sci U S A. 2016;113:E2889-98 pubmed publisher
    ..and cannot explain recent observations in mutants, especially the reduced global diversity of expressed ORs in G9a/GLP knockouts...
  39. Vidal J, de Hollanda A, Jimenez A. GLP-1 is not the key mediator of the health benefits of metabolic surgery. Surg Obes Relat Dis. 2016;12:1225-9 pubmed publisher
    ..effects on glucose metabolism and appetite, amongst the several proposed factors, glucagon-like peptide-1 (GLP-1) has been the most extensively evaluated...
  40. Holst J, McGill M. Potential New Approaches to Modifying Intestinal GLP-1 Secretion in Patients with Type 2 Diabetes Mellitus : Focus on Bile Acid Sequestrants. Clin Drug Investig. 2012;32:1-14 pubmed
    ..The incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) stimulate glucose-induced insulin secretion; however, in patients with type 2 diabetes, the incretin system is ..
  41. Kirov G, Pocklington A, Holmans P, Ivanov D, Ikeda M, Ruderfer D, et al. De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia. Mol Psychiatry. 2012;17:142-53 pubmed publisher
    ..Two de novos also affected EHMT1, a histone methyl transferase known to directly regulate DLG family members...
  42. Tuch B. Clinical use of GLP-1 agonists and DPP4 inhibitors. Pancreatology. 2016;16:8-9 pubmed publisher
    ..and sulfonylureas have been the standard tablets used for this disorder, until 2005-7 when glucagon-like peptide-1 (GLP-1) agonists and dipeptidyl peptidase-4 (DPP4) inhibitors became available...
  43. Weston C, Lu J, Li N, Barkan K, Richards G, Roberts D, et al. Modulation of Glucagon Receptor Pharmacology by Receptor Activity-modifying Protein-2 (RAMP2). J Biol Chem. 2015;290:23009-22 pubmed publisher
    The glucagon and glucagon-like peptide-1 (GLP-1) receptors play important, opposing roles in regulating blood glucose levels. Consequently, these receptors have been identified as targets for novel diabetes treatments...
  44. Kuhre R, Wewer Albrechtsen N, Deacon C, Balk Møller E, Rehfeld J, Reimann F, et al. Peptide production and secretion in GLUTag, NCI-H716, and STC-1 cells: a comparison to native L-cells. J Mol Endocrinol. 2016;56:201-11 pubmed publisher
    ..and STC-1 are cell lines that are widely used to study mechanisms underlying secretion of glucagon-like peptide-1 (GLP-1), but the extent to which they resemble native L-cells is unknown...
  45. Korol S, Jin Z, Jin Y, Bhandage A, Tengholm A, Gandasi N, et al. Functional Characterization of Native, High-Affinity GABAA Receptors in Human Pancreatic ? Cells. EBioMedicine. 2018;30:273-282 pubmed publisher
    ..were enhanced by the benzodiazepine diazepam, the anesthetic propofol and the incretin glucagon-like peptide-1 (GLP-1) but not affected by the hypnotic zolpidem...
  46. Kang M, Oh T, Cho Y. Glucagon-Like Peptide-1 Increases Mitochondrial Biogenesis and Function in INS-1 Rat Insulinoma Cells. Endocrinol Metab (Seoul). 2015;30:216-20 pubmed publisher
    Glucagon-like peptide-1 (GLP-1) is a gut-derived incretin hormone that increases glucose-stimulated insulin secretion in pancreatic β-cells...
  47. Tonneijck L, Smits M, Muskiet M, Hoekstra T, Kramer M, Danser A, et al. Renal Effects of DPP-4 Inhibitor Sitagliptin or GLP-1 Receptor Agonist Liraglutide in Overweight Patients With Type 2 Diabetes: A 12-Week, Randomized, Double-Blind, Placebo-Controlled Trial. Diabetes Care. 2016;39:2042-2050 pubmed
    To investigate effects of dipeptidyl peptidase-4 inhibitor (DPP-4I) sitagliptin or glucagon-like peptide 1 (GLP-1) receptor agonist liraglutide treatment on renal hemodynamics, tubular functions, and markers of renal damage in overweight ..
  48. Bock I, Nemeth K, Pentelenyi K, Balicza P, Balázs A, Molnar M, et al. Targeted next generation sequencing of a panel of autism-related genes identifies an EHMT1 mutation in a Kleefstra syndrome patient with autism and normal intellectual performance. Gene. 2016;595:131-141 pubmed publisher
    ..this workflow, we identified a de novo mutation in the euchromatic histone-lysine N-methyltransferase 1 gene (EHMT1) of an autistic patient with dysmorphisms...
  49. Linden L, Gordon K, Pani A, Payne S, Garde A, Burkholder D, et al. Identification of regulators of germ stem cell enwrapment by its niche in C. elegans. Dev Biol. 2017;429:271-284 pubmed publisher
    ..DTC plexus elaboration via loss of two candidates including lin-40 indicate that cellular enwrapment promotes GLP-1/Notch signaling and germ stem cell fate...
  50. Jang Y, Lee K, Jung K, Kang S, Pagire S, Lee J, et al. Design, synthesis, and biological evaluation of aryl N-methoxyamide derivatives as GPR119 agonists. Bioorg Med Chem Lett. 2017;27:3909-3914 pubmed publisher
    ..Among them, compound 9c displayed good in vitro activity and potency. Moreover, compound 9c lowered glucose excursion in mice in an oral glucose tolerance test and increased GLP-1 secretion in intestinal cells.
  51. Xu F, Wang K, Wang N, Li G, Liu D. Modified human glucagon-like peptide-1 (GLP-1) produced in E. coli has a long-acting therapeutic effect in type 2 diabetic mice. PLoS ONE. 2017;12:e0181939 pubmed publisher
    Glucagon-like peptide 1 (GLP-1) is a very potent insulinotropic hormone secreted into the blood stream after eating. Thus, it has potential to be used in therapeutic treatment of diabetes...
  52. Mayfield K, Siskind D, Winckel K, Russell A, Kisely S, Smith G, et al. Glucagon-like peptide-1 agonists combating clozapine-associated obesity and diabetes. J Psychopharmacol. 2016;30:227-36 pubmed publisher
    ..Recent studies suggest that glucagon-like peptide-1 (GLP-1) may play a key role in clozapine's metabolic effects, possibly suggesting that clozapine-associated obesity and ..
  53. Kashihara H, Shimada M, Yoshikawa K, Higashijima J, Nakao T, Nishi M, et al. Duodenal-jejunal bypass changes the composition of the gut microbiota. Surg Today. 2017;47:137-140 pubmed
    ..in rats after duodenal-jejunal bypass (DJB) in comparison to that in rats injected with a glucagon-like peptide-1 (GLP-1) receptor analog...
  54. Htike Z, Zaccardi F, Papamargaritis D, Webb D, Khunti K, Davies M. Efficacy and safety of glucagon-like peptide-1 receptor agonists in type 2 diabetes: A systematic review and mixed-treatment comparison analysis. Diabetes Obes Metab. 2017;19:524-536 pubmed publisher
    To compare efficacy and safety of glucagon-like peptide-1 receptor agonists (GLP-1RAs) in people with type 2 diabetes.
  55. Li Z, Fang J, Jiao R, Wei X, Ma Y, Liu X, et al. A novel multi-epitope vaccine based on Dipeptidyl Peptidase 4 prevents streptozotocin-induced diabetes by producing anti-DPP4 antibody and immunomodulatory effect in C57BL/6J mice. Biomed Pharmacother. 2017;89:1467-1475 pubmed publisher
    ..in the treatment of type 2 diabetes mellitus by inhibiting the enzymatic degradation of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP)...
  56. Kohashi K, Hiromura M, Mori Y, Terasaki M, Watanabe T, Kushima H, et al. A Dipeptidyl Peptidase-4 Inhibitor but not Incretins Suppresses Abdominal Aortic Aneurysms in Angiotensin II-Infused Apolipoprotein E-Null Mice. J Atheroscler Thromb. 2016;23:441-54 pubmed publisher
    ..We reported that incretins [glucagon-like peptide (GLP)-1 and glucose-dependent insulinotropic polypeptide (GIP)] or a dipeptidyl peptidase-4 inhibitor (DPP-4I) ..
  57. Meier J. [Treatment of type 2 diabetes]. Internist (Berl). 2016;57:153-65 pubmed publisher
    ..insulin at mealtime or by combining basal insulin with oral glucose-lowering drugs or a glucagon-like peptide (GLP)-1 analogue...
  58. Dalefield R, Gosse M, Mueller U. A 28-day oral toxicity study of echimidine and lasiocarpine in Wistar rats. Regul Toxicol Pharmacol. 2016;81:146-154 pubmed publisher
    ..This GLP study was conducted to assess the subchronic dietary toxicity of echimidine to rats compared to that of ..
  59. Pastel E, Joshi S, Knight B, Liversedge N, Ward R, Kos K. Effects of Exendin-4 on human adipose tissue inflammation and ECM remodelling. Nutr Diabetes. 2016;6:e235 pubmed publisher
    Subjects with type-2 diabetes are typically obese with dysfunctional adipose tissue (AT). Glucagon-like peptide-1 (GLP-1) analogues are routinely used to improve glycaemia...
  60. Zhang Z, Liu H, Li Q. Glucagon-like peptide-1 effects lipotoxic oxidative stress by regulating the expression of microRNAs. Biochem Biophys Res Commun. 2017;482:1462-1468 pubmed publisher
    Aim to confirm whether the treatment of GLP-1 can modulated body weight, lipid metabolism, insulin content, pancreas oxidative stress, improved T-AOC, MDA levels related to FFA-Induced oxidative stress in C57BL/6 mice and INS-1 cells...
  61. Nguyen D, Linderholm A, Haczku A, Kenyon N. Glucagon-like peptide 1: A potential anti-inflammatory pathway in obesity-related asthma. Pharmacol Ther. 2017;180:139-143 pubmed publisher
    ..end-products (AGEs), crucial mechanisms in obesity-related asthma, can be modulated by glucagon-like peptide 1 (GLP-1). l-arginine dysregulation in obesity promotes inflammation and bronchoconstriction...
  62. Lambadiari V, Pavlidis G, Kousathana F, Varoudi M, Vlastos D, Maratou E, et al. Effects of 6-month treatment with the glucagon like peptide-1 analogue liraglutide on arterial stiffness, left ventricular myocardial deformation and oxidative stress in subjects with newly diagnosed type 2 diabetes. Cardiovasc Diabetol. 2018;17:8 pubmed publisher
    ..the changes in arterial stiffness and left ventricular (LV) myocardial deformation after 6-month treatment with the GLP-1 analogue liraglutide in subjects with newly diagnosed T2DM...
  63. Owolabi B, Ojo O, Srinivasan D, Conlon J, Flatt P, Abdel Wahab Y. Glucoregulatory, endocrine and morphological effects of [P5K]hymenochirin-1B in mice with diet-induced glucose intolerance and insulin resistance. Naunyn Schmiedebergs Arch Pharmacol. 2016;389:769-81 pubmed publisher
    ..Expression of the Glp1r (GLP-1 receptor) and Gipr (GIP receptor) genes was significantly elevated in islets from peptide-treated mice...
  64. Mori A, Ueda K, Lee P, Oda H, Ishioka K, Arai T, et al. Effect of Acarbose, Sitagliptin and combination therapy on blood glucose, insulin, and incretin hormone concentrations in experimentally induced postprandial hyperglycemia of healthy cats. Res Vet Sci. 2016;106:131-4 pubmed publisher
    ..effect on short-term post-prandial serum glucose, insulin, and incretin hormone (active glucagon-like peptide-1 (GLP-1) and total glucose dependent insulinotropic polypeptide (GIP)) concentrations in five healthy cats, following ..
  65. Saif M, Heaton A, Lilischkis K, Garner J, Brown D. Pharmacology and toxicology of the novel investigational agent Cantrixil (TRX-E-002-1). Cancer Chemother Pharmacol. 2017;79:303-314 pubmed publisher
    ..The studies presented here justify further development. A GLP dog CV study using a 4 × 4 Latin Square Crossover study was conducted using telemetric ECG recordings from dogs ..
  66. Han J, Fei Y, Zhou F, Chen X, Zhang Y, Liu L, et al. Xenopus GLP-1 derived and PEGylated GLP-1 receptor agonists: long-acting hypoglycemic and insulinotropic activities with potential therapeutic utilities. Br J Pharmacol. 2017;: pubmed publisher
    Incretin-based therapies based on glucagon-like peptide-1 (GLP-1) receptor agonists are effective methods for treating type 2 diabetes. Numerous research efforts are focused on the development of long-acting GLP-1 receptor agonists...
  67. Kumari P, Nakata M, Zhang B, Otgon Uul Z, Yada T. GLP-1 receptor agonist liraglutide exerts central action to induce β-cell proliferation through medulla to vagal pathway in mice. Biochem Biophys Res Commun. 2018;499:618-625 pubmed publisher
    Endogenous GLP-1 and GLP-1 receptor agonists (GLP-1RAs) regulate glucose metabolism via common and distinct mechanisms...
  68. BuÅ‚dak Å, Łabuzek K, BuÅ‚dak R, Machnik G, BoÅ‚dys A, OkopieÅ„ B. Exenatide (a GLP-1 agonist) improves the antioxidative potential of in vitro cultured human monocytes/macrophages. Naunyn Schmiedebergs Arch Pharmacol. 2015;388:905-19 pubmed publisher
    ..Novel antidiabetic drugs (e.g., glucagon-like peptide-1 (GLP-1) agonists) were shown to reduce ROS level...
  69. Koshal P, Kumar P. Effect of Liraglutide on Corneal Kindling Epilepsy Induced Depression and Cognitive Impairment in Mice. Neurochem Res. 2016;41:1741-50 pubmed publisher
    b>GLP-1 play important role in neuroprotection and GLP-1 receptor deficit mice showed decreased seizure threshold and increased cognitive impairment...
  70. Lee I, Kim K, Kim K, Park J, Jeong H, Kim Y, et al. Anti-diabetic and anti-obesitic effects of aqueous extracts of Yangkyuksanhwa-tang and its two major compositions on db/db mice. Biomed Pharmacother. 2016;83:431-438 pubmed publisher
    ..Mice treated with RG or YKSHT showed reduced blood glucose levels after stimulating the plasma GLP-1 levels...
  71. Melo N, Mulder K, Nicola A, Carvalho L, Menino G, Mulinari E, et al. Effect of Pyruvate Decarboxylase Knockout on Product Distribution Using Pichia pastoris (Komagataella phaffii) Engineered for Lactic Acid Production. Bioengineering (Basel). 2018;5: pubmed publisher
    ..pastoris. To this end, a strain designated GLp was constructed by inserting the bovine lactic acid dehydrogenase gene (LDHb) concomitantly with the interruption ..
  72. Uccellatore A, Genovese S, Dicembrini I, Mannucci E, Ceriello A. Comparison Review of Short-Acting and Long-Acting Glucagon-like Peptide-1 Receptor Agonists. Diabetes Ther. 2015;6:239-56 pubmed publisher
    ..position statement, the American Diabetes Association and European Association for the Study of Diabetes recommend GLP1-RAs as add-on to metformin when therapeutic goals are not achieved with monotherapy, particularly for patients who ..
  73. Hawes E, WEHBY J, Mounsey A. What next when metformin isn't enough for type 2 diabetes?. J Fam Pract. 2016;65:85-9 pubmed
    This patient-centered case vignette offers insight into how best to choose among additional oral agents, basal insulin, or the newer GLP-1 receptor agonists.
  74. Singh S, Wright E, Kwan A, Thompson J, Syed I, Korol E, et al. Glucagon-like peptide-1 receptor agonists compared with basal insulins for the treatment of type 2 diabetes mellitus: a systematic review and meta-analysis. Diabetes Obes Metab. 2017;19:228-238 pubmed publisher
    Since 2005, several glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have been approved to treat people with type 2 diabetes. These agents are considered for use at the same point in the treatment paradigm as basal insulins...
  75. Normand E, Franco A, Moreau A, Marcil V. Dipeptidyl Peptidase-4 and Adolescent Idiopathic Scoliosis: Expression in Osteoblasts. Sci Rep. 2017;7:3173 pubmed publisher
    ..In circulation, dipeptidyl peptidase-4 (DPP-4) inactivates glucagon-like peptide-1 (GLP-1), an incretin that promotes insulin secretion and sensitivity...
  76. Huang C, Yuan L, Cao S. Endogenous GLP-1 as a key self-defense molecule against lipotoxicity in pancreatic islets. Int J Mol Med. 2015;36:173-85 pubmed publisher
    ..cells is known to increase in response to β cell injury and these cells then generate glucagon-like peptide-1 (GLP-1), thus attenuating the development of diabetes...
  77. Li F, Cao H, Sheng C, Sun H, Song K, Qu S. Upregulated Pdx1 and MafA Contribute to β-Cell Function Improvement by Sleeve Gastrectomy. Obes Surg. 2016;26:904-9 pubmed publisher
    ..The glucose-stimulated acute insulin response was restored in the T2D patients after SG. The expression of GLP-1 in colonic tissue as well as β-cell specific transcription factors (TFs), Pdx1, and MafA in islets was ..
  78. Luo Y, Pan Q, Yao S, Yu M, Wu W, Xue H, et al. Glucagon-Like Peptide-1 Receptor PET/CT with 68Ga-NOTA-Exendin-4 for Detecting Localized Insulinoma: A Prospective Cohort Study. J Nucl Med. 2016;57:715-20 pubmed publisher
    ..We aimed to investigate whether glucagon-like peptide-1 receptor (GLP-1R) PET/CT with (68)Ga-NOTA-MAL-cys(40)-exendin-4 ((68)Ga-NOTA-exendin-4) is efficient in detecting insulinoma...
  79. Hansen M, Scheltema M, Sonne D, Hansen J, Sperling M, Rehfeld J, et al. Effect of chenodeoxycholic acid and the bile acid sequestrant colesevelam on glucagon-like peptide-1 secretion. Diabetes Obes Metab. 2016;18:571-80 pubmed publisher
    ..bile acid sequestrant (BAS) colesevelam, instilled into the stomach, on plasma levels of glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide, glucose, insulin, C-peptide, glucagon, cholecystokinin and ..
  80. Nishimura K, Hiramatsu K, Watanabe T. Dynamics of L cells along the crypt-villous axis in the chicken ileum. Domest Anim Endocrinol. 2016;56:70-4 pubmed publisher
    ..Immunohistochemistry was used to detect the expression of glucagon-like peptide (GLP)-1 and an in situ hybridization technique to detect proglucagon messenger RNA (mRNA)...
  81. Giezenaar C, Trahair L, Luscombe Marsh N, Hausken T, Standfield S, Jones K, et al. Effects of randomized whey-protein loads on energy intake, appetite, gastric emptying, and plasma gut-hormone concentrations in older men and women. Am J Clin Nutr. 2017;106:865-877 pubmed publisher
    ..insulin, glucagon, ghrelin, cholecystokinin, gastric inhibitory polypeptide (GIP), glucagon-like peptide 1 (GLP-1), and peptide tyrosine tyrosine (PYY)] were measured, and ad libitum energy intake was quantified from a buffet ..
  82. Cremonini E, Wang Z, Bettaieb A, Adamo A, Daveri E, Mills D, et al. (-)-Epicatechin protects the intestinal barrier from high fat diet-induced permeabilization: Implications for steatosis and insulin resistance. Redox Biol. 2018;14:588-599 pubmed publisher
    ..EC acted modulating cell signals and the gut hormone GLP-2, which are central to the regulation of intestinal permeability...
  83. Bonadonna R, Borghi C, Consoli A, Volpe M. Novel antidiabetic drugs and cardiovascular risk: Primum non nocere. Nutr Metab Cardiovasc Dis. 2016;26:759-66 pubmed publisher
    ..These are: the incretin mimetics glucagon-like peptide 1 (GLP-1) receptor agonists (GLP1-RA), the incretin enhancers dipeptidylpeptidase-4 (DPP-4) inhibitors (DPP4-I or gliptins), and the sodium-glucose ..
  84. Fortin S, Roitman M. Central GLP-1 receptor activation modulates cocaine-evoked phasic dopamine signaling in the nucleus accumbens core. Physiol Behav. 2017;176:17-25 pubmed publisher
    ..Recently, metabolic regulatory peptides, including the satiety signal glucagon-like peptide-1 (GLP-1), have been shown to modulate cocaine reward-driven behavior and sustained dopamine levels after cocaine ..
  85. Chang J, Liang Y, Hsu C, Chen C, Chen P, Yang Y, et al. Glucagon-like peptide receptor agonists attenuate advanced glycation end products-induced inflammation in rat mesangial cells. BMC Pharmacol Toxicol. 2017;18:67 pubmed publisher
    ..PPARδ agonists also stimulate glucagon-like peptide-1 (GLP-1) secretion from human intestinal cells...
  86. Garella R, Idrizaj E, Traini C, Squecco R, Vannucchi M, Baccari M. Glucagon-like peptide-2 modulates the nitrergic neurotransmission in strips from the mouse gastric fundus. World J Gastroenterol. 2017;23:7211-7220 pubmed publisher
    To investigate whether glucagon-like peptide-2 (GLP-2) influences the neurally-induced responses in gastric strips from mice, since no data are available...
  87. Rinaman L. Interoceptive stress activates glucagon-like peptide-1 neurons that project to the hypothalamus. Am J Physiol. 1999;277:R582-90 pubmed
    This study tested the hypothesis that systemic stressors in rats activate glucagon-like peptide-1 (GLP-1)-immunoreactive neurons in the caudal brain stem, including those that project to the paraventricular nucleus of the hypothalamus (..
  88. Arana M, Tocchetti G, Zecchinati F, Londero A, Dominguez C, Perdomo V, et al. Glucagon-like peptide 2 prevents down-regulation of intestinal multidrug resistance-associated protein 2 and P-glycoprotein in endotoxemic rats. Toxicology. 2017;390:22-31 pubmed publisher
    ..We evaluated the protective effect of glucagon-like peptide 2 (GLP-2), a peptide hormone with enterotrophic properties, on Mrp2 and P-gp alterations induced by single i.p...
  89. Ng C, Tang F, Seeholzer S, Zou Y, De Leon D. Population Pharmacokinetics of Exendin-(9-39) and Clinical Dose Selection in Patients with Congenital Hyperinsulinism. Br J Clin Pharmacol. 2017;: pubmed publisher
    ..Exendin-(9-39), an inverse glucagon-like peptide 1 (GLP-1) agonist, is a novel therapeutic agent for HI that has demonstrated glucose-raising effect...
  90. Noruzinia M, Ahmadvand M, Bashti O, Salehi Chaleshtori A. Kleefstra Syndrome: The First Case Report From Iran. Acta Med Iran. 2017;55:650-654 pubmed
    ..Deletion of EHMT1 is the main player in 75% of cases...
  91. Agarwal I, Farnow C, Jiang J, Kim K, Leet D, Solomon R, et al. HOP-1 Presenilin Deficiency Causes a Late-Onset Notch Signaling Phenotype That Affects Adult Germline Function in Caenorhabditis elegans. Genetics. 2018;208:745-762 pubmed publisher
    ..The low-fecundity phenotype of hop-1 mutants can be phenocopied by switching off glp-1/Notch function during the last stage of larval development...
  92. Cegla J, Jones B, Gardiner J, Hodson D, Marjot T, McGlone E, et al. RAMP2 Influences Glucagon Receptor Pharmacology via Trafficking and Signaling. Endocrinology. 2017;158:2680-2693 pubmed publisher
    ..Ligands tested were glucagon; glucagonlike peptide-1 (GLP-1); oxyntomodulin; and analog G(X), a GLP-1/glucagon coagonist developed in-house...