EGR2

Summary

Gene Symbol: EGR2
Description: early growth response 2
Alias: AT591, CMT1D, CMT4E, KROX20, E3 SUMO-protein ligase EGR2, KROX-20, Drosophila, homolog (early growth response-2), early growth response protein 2, zinc finger protein Krox-20
Species: human

Top Publications

  1. ncbi The one-to-four rule and paralogues of sex-determining genes
    S Ohno
    Beckman Research Institute of the City of Hope, Duarte, California 91010 3000, USA
    Cell Mol Life Sci 55:824-30. 1999
  2. pmc Reciprocal co-regulation of EGR2 and MECP2 is disrupted in Rett syndrome and autism
    Susan E Swanberg
    Department of Medical Microbiology and Immunology, Rowe Program in Human Genetics, School of Medicine, University of California, Davis, CA 95616, USA
    Hum Mol Genet 18:525-34. 2009
  3. pmc Yy1 as a molecular link between neuregulin and transcriptional modulation of peripheral myelination
    Ye He
    Department of Neuroscience and Genetics and Genomics, Mount Sinai School of Medicine, New York, New York, USA
    Nat Neurosci 13:1472-80. 2010
  4. ncbi EGR2 induces apoptosis in various cancer cell lines by direct transactivation of BNIP3L and BAK
    Motoko Unoki
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japam
    Oncogene 22:2172-85. 2003
  5. ncbi A novel mutation (D305V) in the early growth response 2 gene is associated with severe Charcot-Marie-Tooth type 1 disease
    E Bellone
    Department of Oncology, Biology and Genetics, University of Genova, Genova Italy
    Hum Mutat 14:353-4. 1999
  6. doi No association between EGR gene family polymorphisms and schizophrenia in the Chinese population
    Bao Cheng Liu
    Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai 200030, PR China
    Prog Neuropsychopharmacol Biol Psychiatry 34:506-9. 2010
  7. doi EGR3 as a potential susceptibility gene for schizophrenia in Korea
    Se Hyun Kim
    Department of Psychiatry and Behavioral Science, Seoul National University College of Medicine, Seoul, Republic of Korea
    Am J Med Genet B Neuropsychiatr Genet 153:1355-60. 2010
  8. ncbi Krox-20 controls myelination in the peripheral nervous system
    P Topilko
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, Paris, France
    Nature 371:796-9. 1994
  9. ncbi Novel EGR2 mutation R359Q is associated with CMT type 1 and progressive scoliosis
    E Mikesová
    Department of Child Neurology, 2nd School of Medicine, Charles University Prague, V Uvalu 84, 15006 Prague, Czech Republic
    Neuromuscul Disord 15:764-7. 2005
  10. ncbi A novel missense mutation in the early growth response 2 gene associated with late-onset Charcot--Marie--Tooth disease type 1
    T Yoshihara
    Department of Neurology, Nagoya University School of Medicine, Nagoya 466, Japan
    J Neurol Sci 184:149-53. 2001

Detail Information

Publications158 found, 100 shown here

  1. ncbi The one-to-four rule and paralogues of sex-determining genes
    S Ohno
    Beckman Research Institute of the City of Hope, Duarte, California 91010 3000, USA
    Cell Mol Life Sci 55:824-30. 1999
    ..One consisted of EGR1, EGR2, EGR3 and EGR4, whereas the only known paralogue of the other is WT1, which controls the developmental fate of the ..
  2. pmc Reciprocal co-regulation of EGR2 and MECP2 is disrupted in Rett syndrome and autism
    Susan E Swanberg
    Department of Medical Microbiology and Immunology, Rowe Program in Human Genetics, School of Medicine, University of California, Davis, CA 95616, USA
    Hum Mol Genet 18:525-34. 2009
    ..The activity-dependent early growth response gene 2 (EGR2), required for both early hindbrain development and mature neuronal function, has predicted binding sites in the ..
  3. pmc Yy1 as a molecular link between neuregulin and transcriptional modulation of peripheral myelination
    Ye He
    Department of Neuroscience and Genetics and Genomics, Mount Sinai School of Medicine, New York, New York, USA
    Nat Neurosci 13:1472-80. 2010
    ..The Schwann cells expressed low levels of myelin proteins and of Egr2 (also called Krox20), which is an important regulator of peripheral myelination...
  4. ncbi EGR2 induces apoptosis in various cancer cell lines by direct transactivation of BNIP3L and BAK
    Motoko Unoki
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japam
    Oncogene 22:2172-85. 2003
    b>EGR2 plays a key role in the PTEN-induced apoptotic pathway...
  5. ncbi A novel mutation (D305V) in the early growth response 2 gene is associated with severe Charcot-Marie-Tooth type 1 disease
    E Bellone
    Department of Oncology, Biology and Genetics, University of Genova, Genova Italy
    Hum Mutat 14:353-4. 1999
    ..Recently point mutations in the early growth response 2 gene (EGR2/Krox-20) have been associated with hereditary myelinopathies...
  6. doi No association between EGR gene family polymorphisms and schizophrenia in the Chinese population
    Bao Cheng Liu
    Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai 200030, PR China
    Prog Neuropsychopharmacol Biol Psychiatry 34:506-9. 2010
    ..In this study we investigated the role of EGR1, EGR2, EGR3 and EGR4 within the EGR family...
  7. doi EGR3 as a potential susceptibility gene for schizophrenia in Korea
    Se Hyun Kim
    Department of Psychiatry and Behavioral Science, Seoul National University College of Medicine, Seoul, Republic of Korea
    Am J Med Genet B Neuropsychiatr Genet 153:1355-60. 2010
    ..EGR genes, including EGR2, EGR3, and EGR4, showed significant association with schizophrenia in Japanese schizophrenic pedigrees...
  8. ncbi Krox-20 controls myelination in the peripheral nervous system
    P Topilko
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, Paris, France
    Nature 371:796-9. 1994
    ..Therefore Krox-20 is likely to control a set of genes required for completion of myelination in the peripheral nervous system...
  9. ncbi Novel EGR2 mutation R359Q is associated with CMT type 1 and progressive scoliosis
    E Mikesová
    Department of Child Neurology, 2nd School of Medicine, Charles University Prague, V Uvalu 84, 15006 Prague, Czech Republic
    Neuromuscul Disord 15:764-7. 2005
    Mutations in the early growth response 2 gene (EGR2) cause demyelinating neuropathies differing in severity and age of onset...
  10. ncbi A novel missense mutation in the early growth response 2 gene associated with late-onset Charcot--Marie--Tooth disease type 1
    T Yoshihara
    Department of Neurology, Nagoya University School of Medicine, Nagoya 466, Japan
    J Neurol Sci 184:149-53. 2001
    A novel mutation (Arg381Cys) in the second zinc-finger domain of early growth response 2 (EGR2) was identified in a late-onset Charcot--Marie--Tooth disease type 1 (CMT1) patient...
  11. ncbi HCF-1 functions as a coactivator for the zinc finger protein Krox20
    Randy L Luciano
    Department of Microbiology and New York University Cancer Institute, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 278:51116-24. 2003
    ..Three well characterized examples were further analyzed for their ability to use HCF-1 as a coactivator. Krox20, a zinc finger transcription factor required for Schwann cell differentiation, and E2F4, a cell cycle regulator, ..
  12. ncbi Methylation at CpG islands in intron 1 of EGR2 confers enhancer-like activity
    Motoko Unoki
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    FEBS Lett 554:67-72. 2003
    We previously demonstrated several lines of evidence indicating that early growth response 2 (EGR2) functions as a tumor suppressor, partly on the basis that its expression was often decreased in human tumors and cancer cell lines...
  13. pmc Toxoplasma gondii rhoptry discharge correlates with activation of the early growth response 2 host cell transcription factor
    Eric D Phelps
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Infect Immun 76:4703-12. 2008
    ..Early growth response 2 (EGR2) is a host cell transcription factor that is rapidly upregulated and activated in Toxoplasma-infected cells but not ..
  14. ncbi Cranial nerve involvement in CMT disease type 1 due to early growth response 2 gene mutation
    D Pareyson
    Departments of Neurology, C Besta National Neurological Institute, Milan, Italy
    Neurology 54:1696-8. 2000
    Mutations in the gene coding for the Schwann cell transcription factor early growth response 2 (EGR2), which seems to regulate myelinogenesis and hindbrain development, have been observed in few cases of inherited neuropathy...
  15. ncbi [The genetics of type 1 Charcot-Marie-Tooth disease, the hereditary focal neuropathies and the hereditary distal motor neuropathies]
    T Sevilla
    , Hospital Universitario La Fe, Valencia,
    Rev Neurol 30:71-9. 2000
    ..1q23 (locus CMT-1B); the gene for conexine 32 (Cx32), found on chromosome Xq13 (locus CMT-X) and the gene EGR2 found on chromosome 10q21.1-q22.1...
  16. ncbi Embryology of the neural crest: its inductive role in the neurocutaneous syndromes
    Harvey B Sarnat
    Department of Pediatrics Neurology, University of Calgary, Faculty of Medicine, Alberta Children s Hospital, Calgary, AB, Canada
    J Child Neurol 20:637-43. 2005
    ..of the neural tube (eg, PAX3, BMP4, ZIC2), some segmentation genes (eg, WNT1), genes that inhibit neural crest (eg, EGR2), and neural crest-specific differentiating genes (eg, SLUG, SOX10)...
  17. ncbi Regulation of myelin-specific gene expression. Relevance to CMT1
    J Kamholz
    Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Ann N Y Acad Sci 883:91-108. 1999
    ..Two transcription factors, Krox 20 (EGR2) and Oct 6 (SCIP/Tst1), are necessary for the transition from the promyelinating to the myelinating stage of ..
  18. ncbi Coordinate augmentation in expression of genes encoding transcription factors and liver secretory proteins in hypo-oncotic states
    J Kang
    Department of Biological Chemistry, University of California, Davis 95616, USA
    Kidney Int 56:452-60. 1999
    ..This is the only known condition in which transcription of both positive and negative acute phase proteins (APPs) are increased simultaneously. The specific transcription factor(s) that might regulate this cascade is not defined...
  19. ncbi A somatic and germline mosaic mutation in MPZ/P(0) mimics recessive inheritance of CMT1B
    G M Fabrizi
    Department of Neurological and Visual Sciences, Section of Clinical Neurology, University of Verona, Italy
    Neurology 57:101-5. 2001
    ..To identify the molecular basis of a demyelinating Charcot-Marie-Tooth disease type 1 (CMT1) with presumed autosomal recessive inheritance...
  20. ncbi A novel type of hereditary motor and sensory neuropathy characterized by a mild phenotype
    P De Jonghe
    Department of Biochemistry, University Hospital Antwerp, Belgium
    Arch Neurol 56:1283-8. 1999
    ..2 (CMT1A), 1q21-q23 (CMT1B), and 10q21.1-q22.1 (designated here as CMT1D)...
  21. ncbi Glucocorticoids inhibit osteocalcin transcription in osteoblasts by suppressing Egr2/Krox20-binding enhancer
    Nathalie Leclerc
    University of Southern California Keck School of Medicine, Los Angeles 90033, USA
    Arthritis Rheum 52:929-39. 2005
    ..Using this gene as a model, the goal of this study was to discover glucocorticoid-sensitive transcriptional mechanisms in osteoblasts...
  22. ncbi Molecular analysis in Japanese patients with Charcot-Marie-Tooth disease: DGGE analysis for PMP22, MPZ, and Cx32/GJB1 mutations
    Chikahiko Numakura
    Department of Pediatrics, Yamagata University School of Medicine, Yamagata, Japan
    Hum Mutat 20:392-8. 2002
    ..myelin protein 22 (PMP22), myelin protein zero (MPZ), connexin 32 (Cx32/GJB1), and early growth response 2 (EGR2) genes. Some mutations of MPZ and Cx32 were also associated with the clinical CMT2 phenotype...
  23. ncbi Charcot-marie-tooth disease and related neuropathies: molecular basis for distinction and diagnosis
    D Pareyson
    Department of Neurology, Istituto Nazionale Neurologico C Besta, Via Celoria 11, 20133 Milan, Italy
    Muscle Nerve 22:1498-509. 1999
    ..myelin protein 22 (PMP22), myelin protein zero (PO), connexin 32 (Cx32), and early growth response 2 (EGR2)...
  24. doi 5q- myelodysplastic syndromes: chromosome 5q genes direct a tumor-suppression network sensing actin dynamics
    K M Eisenmann
    Laboratories of Cell Structure and Signal Integration, Van Andel Research Institute, Grand Rapids, MI 49503, USA
    Oncogene 28:3429-41. 2009
    ..identified candidate tumor-suppressor genes, including the ribosomal subunit RPS14, the transcription factor Egr1/Krox20 and the cytoskeletal remodeling protein, alpha-catenin...
  25. ncbi Clinical, electrophysiological and molecular genetic studies in a family with X-linked dominant Charcot-Marie-Tooth neuropathy presenting a novel mutation in GJB1 Promoter and a rare polymorphism in LITAF/SIMPLE
    Katell Beauvais
    Unité de Neurophysiologie Clinique, Hôpital Yves Le Foll, 22023 Saint Brieuc, France
    Neuromuscul Disord 16:14-8. 2006
    ..Charcot-Marie-Tooth disease with dominant inheritance, five genes have been incriminated: PMP22, MPZ, LITAF/SIMPLE, EGR2 (CMT1A to D), and GJB1 (CMTX)...
  26. doi Neurofilament light chain polypeptide gene mutations in Charcot-Marie-Tooth disease: nonsense mutation probably causes a recessive phenotype
    Akiko Abe
    Department of Pediatrics, Yamagata University School of Medicine, Yamagata, Japan
    J Hum Genet 54:94-7. 2009
    ..We investigated NEFL in 223 Japanese CMT patients who were negative for PMP22, MPZ, GJB1, LITAF, EGR2, GDAP1, MTMR2 and PRX in the demyelinating form and negative for MFN2, MPZ, GJB1, HSP27, HSP22 and GARS in the ..
  27. doi Clinical characterization and genetic analysis of a possible novel type of dominant Charcot-Marie-Tooth disease
    Yi Chung Lee
    Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan
    Neuromuscul Disord 20:534-9. 2010
    ..No mutation in PMP22, MPZ, GJB1, NEFL, LITAF, EGR2, MFN2, HSP27, HSP22, GADP1, YARS, and DNM2 genes was found in the proband...
  28. doi Dicer in Schwann cells is required for myelination and axonal integrity
    Jorge A Pereira
    Institute of Cell Biology, Department of Biology, Eidgenossische Technische Hochschule ETH Zurich, CH 8093 Zurich, Switzerland
    J Neurosci 30:6763-75. 2010
    ..At the molecular level, the promyelinating transcription factor Krox20 and several myelin proteins [including myelin associated glycoprotein (MAG) and PMP22] were strongly reduced in ..
  29. ncbi Congenital hypomyelination neuropathy in a newborn infant: unusual cause of diaphragmatic and vocal cord paralyses
    J S Hahn
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Lucile Packard Children s Hospital at Stanford, Stanford, California, USA
    Pediatrics 108:E95. 2001
    ..DNA analysis for identification of previously characterized mutations in the genes MPZ, PMP22, and EGR2 was negative...
  30. pmc Differential regulation of NAB corepressor genes in Schwann cells
    Rajini Srinivasan
    Department of Comparative Biosciences, University of Wisconsin Madison, Madison, WI, USA
    BMC Mol Biol 8:117. 2007
    Myelination of peripheral nerves by Schwann cells requires not only the Egr2/Krox-20 transactivator, but also the NGFI-A/Egr-binding (NAB) corepressors, which modulate activity of Egr2...
  31. pmc Identifying significant genetic regulatory networks in the prostate cancer from microarray data based on transcription factor analysis and conditional independency
    Hsiang Yuan Yeh
    Department of Computer Science, National Tsing Hua University, Hsinchu 300, Taiwan
    BMC Med Genomics 2:70. 2009
    ....
  32. pmc Inverse regulation of plasticity-related immediate early genes by calcineurin in hippocampal neurons
    Brian Yee Hong Lam
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, United Kingdom
    J Biol Chem 284:12562-71. 2009
    ..the IEG c-fos is unaffected by suppression of calcineurin activity, the plasticity-related genes Egr1/Zif268 and Egr2/Krox-20 are up-regulated, and genes encoding the orphan nuclear hormone receptors Nor1 and Nur77 are down-regulated...
  33. ncbi Experience-dependent plasticity of mouse visual cortex in the absence of the neuronal activity-dependent marker egr1/zif268
    N Mataga
    Laboratory for Neuronal Circuit Development, Brain Science Institute, RIKEN, 351 0198 Japan
    J Neurosci 21:9724-32. 2001
    ..There was no apparent compensation among egr2, egr3, or c-fos mRNA and protein expression in the visual cortex of egr1 KO mice...
  34. pmc Neural-specific expression, genomic structure, and chromosomal localization of the gene encoding the zinc-finger transcription factor NGFI-C
    S D Crosby
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110
    Proc Natl Acad Sci U S A 89:4739-43. 1992
    ..related to the previously described early response genes, nerve growth factor-induced clone A (NGFI-A or EGR1), EGR2, and EGR3...
  35. pmc Developmental basis of the rostro-caudal organization of the brainstem respiratory rhythm generator
    J Champagnat
    Centre de Recherche de Gif, UPR 2216 Neurobiologie Génétique et Intégrative, IFR 2118 Institut de Neurobiologie Alfred Fessard, CNRS, 91198 Gif sur Yvette, France
    Philos Trans R Soc Lond B Biol Sci 364:2469-76. 2009
    ..Inactivation of Krox20/Egr2 eliminates the pFRG activity, thereby causing life-threatening neonatal apnoeas alternating with respiration ..
  36. ncbi Binding of transcription factor Sp1 to GC box DNA revealed by footprinting analysis: different contact of three zinc fingers and sequence recognition mode
    J Kuwahara
    Institute for Chemical Research, Kyoto University, Japan
    Biochemistry 32:5994-6001. 1993
    ..These features are clearly distinct from those of Zif268 and Krox20, which are three-zinc-finger proteins closely related to Sp1.
  37. ncbi Neural crest patterning: autoregulatory and crest-specific elements co-operate for Krox20 transcriptional control
    Julien Ghislain
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, 46 rue d Ulm, 75230 Paris Cedex 05, France
    Development 130:941-53. 2003
    ..b>Krox20, a transcription factor gene that plays a critical role in the development of the segmented hindbrain, is ..
  38. ncbi [Experimental identification of drugs with function of targeted up-regulating ID4 expression: bioinformatics-based prediction and preliminary validation]
    Bo Yang
    Department of Geriatric Hematology, Chinese PLA General Hospital, Beijing 100853, China
    Zhonghua Yi Xue Za Zhi 89:1714-6. 2009
    ..To screen new candidate molecular-targeted anti-leukemia compounds with potential functions of targeted up-regulating ID4 gene expression...
  39. pmc Neurotrophin/Trk receptor signaling mediates C/EBPalpha, -beta and NeuroD recruitment to immediate-early gene promoters in neuronal cells and requires C/EBPs to induce immediate-early gene transcription
    Anna Maria Calella
    European Molecular Biology Laboratory, Mouse Biology Unit, Via Ramarini, 00016 Monterotondo, Italy
    Neural Dev 2:4. 2007
    ....
  40. pmc Molecular cloning of a novel human cDNA encoding a zinc finger protein that binds to the interleukin-3 promoter
    N Koyano-Nakagawa
    Department of Molecular and Development Biology, Institute of Medical Science, University of Tokyo, Japan
    Mol Cell Biol 14:5099-107. 1994
    ..Two were identical to known transcription factors, EGR1 and EGR2, and the other clone, named DB1, encoded a novel protein of 516 amino acids with six zinc finger motifs...
  41. pmc Rapid effects of LH on gene expression in the mural granulosa cells of mouse periovulatory follicles
    Martha Z Carletti
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, 3075 KLSIC, 3901 Rainbow Boulevard, Kansas City, Kansas 66160, USA
    Reproduction 137:843-55. 2009
    ..Temporal expression of several transcripts, including the transcription factors Nr4a1, Nr4a2, Egr1, Egr2, Btg1, and Btg2, and the epidermal growth factor (EGF)-like ligands Areg and Ereg, were analyzed by quantitative RT-..
  42. doi Microarray analysis reveals differential expression of benign and malignant pheochromocytoma
    Jens Waldmann
    Department of Surgery, Philipps Universitat Marburg, Baldingerstrasse, D 35043 Marburg, Germany
    Endocr Relat Cancer 17:743-56. 2010
    ..differences of six genes (calsequestrin, NNAT, neurogranin, secreted protein acidic and rich in cysteine (SPARC), EGR2, and MAOB) were confirmed by RT-PCR in 25 PCs...
  43. doi Differential gene expression profiling of large and small retinal ganglion cells
    Dmitry Ivanov
    Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, 1638 NW 10th Avenue, Miami, FL 33136, USA
    J Neurosci Methods 174:10-7. 2008
    ..between the two sub-populations of RGCs are controlled by networks interconnected by SP-1, Erk2 (MAPK1), Egr1, Egr2 and, potentially, regulated via transcription factors C/EBPbeta, HSF1, STAT1- and c-Myc...
  44. ncbi foxD5a, a Xenopus winged helix gene, maintains an immature neural ectoderm via transcriptional repression that is dependent on the C-terminal domain
    S A Sullivan
    Department of Anatomy and Cell Biology, The George Washington University Medical Center, Washington, DC 20037, USA
    Dev Biol 232:439-57. 2001
    ..plate appears to be maintained in an immature state because otx2 expression is expanded and expression of en2, Krox20, proneural genes (Xnrgn1, neuroD) and a neural differentiation gene (n-tubulin) is repressed in foxD5a-expressing ..
  45. ncbi Expression of ABCA2 protein in both non-myelin-forming and myelin-forming Schwann cells in the rodent peripheral nerve
    Takashi Saito
    Department of Physiology, Akita University School of Medicine, Akita 010 8543, Japan
    Neurosci Lett 414:35-40. 2007
    ..not only in Schwann cells, which express the Schwann cell marker S100beta and a zinc finger transcription factor Krox20 (a marker for myelin-forming Schwann cells), but also in Krox20-negative cells, which express glial fibrillary ..
  46. doi Altered brain gene expression profiles associated with the pathogenesis of phenylketonuria in a mouse model
    Joo Won Park
    Department of Biochemistry, School of Medicine, Ewha Womans University, Seoul, South Korea
    Clin Chim Acta 401:90-9. 2009
    ..The resultant hyperphenylalaninemia causes mental retardation, seizure, and abnormalities in behavior and movement...
  47. ncbi Adrenal transcription regulatory genes modulated by angiotensin II and their role in steroidogenesis
    Damian G Romero
    Division of Endocrinology, G V Sonny Montgomery Veterans Affairs Medical Center, Jackson, Mississippi, USA
    Physiol Genomics 30:26-34. 2007
    ..BHLHB2, BTG2, and SALL1 decreased expression of both enzymes, whereas CITED2, EGR2, ELL2, FOS, FOSB, HDAC5, MAFF, MITF, NFIL3, NR4A1, NR4A2, NR4A3, PER1, and VDR increased expression for both ..
  48. ncbi Identification and characterization of TRIP8 gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 12:817-21. 2003
    ..Intra-species comparative genomics revealed that TRIP8-EGR2 locus at human chromosome 10q21...
  49. ncbi Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3
    W G Tourtellotte
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Genet 20:87-91. 1998
    ..The Egr family of zinc-finger transcription factors, whose members include Egr1 (NGFI-A), Egr2 (Krox-20), Egr3 and Egr4 (NGFI-C), are thought to regulate critical genetic programs involved in cellular growth ..
  50. pmc Active gene repression by the Egr2.NAB complex during peripheral nerve myelination
    Gennifer M Mager
    Molecular and Cellular Pharmacology Training Program, Department of Comparative Biosciences, Graduate Program in Cellular and Molecular Biology, University of Wisconsin, Madison, WI 53706, USA
    J Biol Chem 283:18187-97. 2008
    The Egr2/Krox20 transactivator is required for activation of many myelin-associated genes during peripheral nerve myelination by Schwann cells...
  51. ncbi Dejerine-Sottas disease and hereditary demyelinating polyneuropathy of infancy
    Violaine Plante-Bordeneuve
    Department of Neurology, Centre Hospitalier Universitaire de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre, France
    Muscle Nerve 26:608-21. 2002
    ..in the original study, and at least seven genes encoding the myelin proteins P0, PMP22, the transcriptional factor EGR2, and others have been implicated...
  52. ncbi Retinoic acid synthesis and hindbrain patterning in the mouse embryo
    K Niederreither
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, CU de Strasbourg
    Development 127:75-85. 2000
    ..Instead of being expressed in two alternate rhombomeres (r3 and r5), Krox20 is expressed in a single broad domain, correlating with an abnormal expansion of the r2-r3 marker Meis2...
  53. ncbi The Ddx20/DP103 dead box protein represses transcriptional activation by Egr2/Krox-20
    Anne Lynn Gillian
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Biol Chem 279:9056-63. 2004
    The early growth response 2 (Egr2/Krox-20) transcription factor is essential for myelination of the peripheral nervous system and segmentation of the vertebrate hindbrain...
  54. pmc Neuropathy-associated Egr2 mutants disrupt cooperative activation of myelin protein zero by Egr2 and Sox10
    Scott E Leblanc
    University of Wisconsin Madison, WI 53706, USA
    Mol Cell Biol 27:3521-9. 2007
    Dominant mutations in the early growth response 2 (Egr2/Krox20) transactivator, a critical regulator of peripheral myelin development, have been associated with peripheral myelinopathies...
  55. ncbi Activity-dependent gene expression correlates with interictal spiking in human neocortical epilepsy
    Sanjay N Rakhade
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Epilepsia 48:86-95. 2007
    ..We have recently identified a common group of genes induced in human epileptic foci, including EGR1, EGR2, c-fos, and MKP-3...
  56. pmc Induction of myelin protein zero by early growth response 2 through upstream and intragenic elements
    Sung Wook Jang
    Graduate Program in Cellular and Molecular Biology, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Biol Chem 284:20111-20. 2009
    ..of the Mpz gene is controlled by two major transactivators that coordinate Schwann cell development: Egr2/Krox20 and Sox10...
  57. doi CNS/PNS boundary transgression by central glia in the absence of Schwann cells or Krox20/Egr2 function
    Fanny Coulpier
    Plate forme Transcriptome and Developmental Biology Section, INSERM, Unité 1024, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8197, Institut de Biologie de l Ecole Normale Supérieure, 75230 Paris, France
    J Neurosci 30:5958-67. 2010
    ..We show that depletion of Schwann cells and boundary cap cells or inactivation of Krox20/Egr2, a master regulatory gene for myelination in Schwann cells, results in transgression of the CNS/PNS boundary ..
  58. ncbi Differential expression of hoxa2a and hoxa2b genes during striped bass embryonic development
    Jean Luc Scemama
    Department of Biology, Howell Science Complex, East Carolina University, Greenville, NC 27858, USA
    Gene Expr Patterns 6:843-8. 2006
    ..uncharacterized paralogs group 2 Hox genes, striped bass hoxa2a and hoxa2b, and the developmental regulatory gene egr2. We demonstrate that both Hox genes are expressed in the rhombomeres of the developing hindbrain and the pharyngeal ..
  59. ncbi Direct regulation of myelin protein zero expression by the Egr2 transactivator
    Scott E Leblanc
    Molecular and Cellular Pharmacology Program, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Drive, Madison, WI 53705, USA
    J Biol Chem 281:5453-60. 2006
    ..within the first intron of the Mpz gene, which contains binding sites for the early growth response 2 (Egr2/Krox20) transcription factor, a critical regulator of peripheral nerve myelination...
  60. pmc Novel mutants of NAB corepressors enhance activation by Egr transactivators
    J Svaren
    Division of Laboratory Medicine, Departments of Pathology and Internal Medicine, Campus Box 8118, 660 S Euclid Ave, Washington University School of Medicine, St Louis, MO 63110, USA
    EMBO J 17:6010-9. 1998
    ..binding corepressors NAB1 and NAB2 interact with a conserved domain (R1 domain) within the Egr1/NGFI-A and Egr2/Krox20 transactivators, and repress the transcription of Egr target promoters...
  61. ncbi Combined deficiencies of Msx1 and Msx2 cause impaired patterning and survival of the cranial neural crest
    Mamoru Ishii
    Department of Biochemistry and Molecular Biology, Norris Cancer Hospital, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
    Development 132:4937-50. 2005
    ..The expression of the hindbrain markers Krox20 and Epha4 was altered in Msx1/2 mutants, suggesting that defects in neural crest populations may result, in part, ..
  62. ncbi Krox20 is down-regulated following triazole in vitro embryonic exposure: a polycompetitor-based assay
    Valentina Massa
    Department of Biology, University of Milano, Milano, Italy
    Toxicol Lett 169:196-204. 2007
    ..Specification of hindbrain segments is regulated by retinoic acid and the hox code. Krox20 was chosen as molecular marker for its specific distribution in the anterior neural tube...
  63. pmc Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain
    A H Swirnoff
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Cell Biol 18:512-24. 1998
    ..the NGFI-A (Egr-1, Krox24, zif/268) family of immediate-early gene transcription factors, which includes NGFI-C, Krox20, and Egr3...
  64. doi Inhibition of BMPs by follistatin is required for FGF3 expression and segmental patterning of the hindbrain
    Karen Weisinger
    Koret School of Veterinary Medicine, Hebrew University, Faculty of Agriculture, Food and Environmental Quality Sciences, P O Box 12, Rehovot 76100, Israel
    Dev Biol 324:213-25. 2008
    ..FGF signaling is required in this network to upregulate the expression of the Krox20 and Kreisler segmentation genes, but little is known of how FGF gene expression is regulated in the hindbrain...
  65. pmc A novel locus for autosomal recessive peripheral neuropathy in the EGR2 region on 10q23
    T Rogers
    Centre for Human Genetics, Edith Cowan University Joondalup Campus, Perth, WA 6027, Australia
    Am J Hum Genet 67:664-71. 2000
    ..branches of the large kindred detected linkage to the 10q22-q23 region containing the early growth response 2 gene (EGR2), a transcription factor with a key role in peripheral nerve myelination...
  66. ncbi Anterior patterning by synergistic activity of the early gastrula organizer and the anterior germ layer tissues of the mouse embryo
    P P Tam
    Embryology Unit, Children s Medical Research Institute, Locked Bag 23, Wentworthville, NSW 2145, Australia
    Development 126:5171-9. 1999
    ..However, the most anterior neural gene that was expressed in the ectopic axis was Krox20 that marks parts of the hindbrain, but markers of the mid- and forebrain (Otx2 and En1) were not expressed...
  67. ncbi Krox20 stimulates adipogenesis via C/EBPbeta-dependent and -independent mechanisms
    Zhu Chen
    Laboratory of Molecular Genetics, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Cell Metab 1:93-106. 2005
    b>Krox20 is a zinc finger-containing transcription factor that is abundantly expressed in adipose tissue. However, its role in fat cell differentiation has not been established...
  68. ncbi In vivo detection of Egr2 binding to target genes during peripheral nerve myelination
    Sung Wook Jang
    Graduate Program in Cellular and Molecular Biology, University of Wisconsin, Madison, Wisconsin, USA
    J Neurochem 98:1678-87. 2006
    Egr2/Krox20 is a zinc finger transactivator that regulates a diverse array of genes required for peripheral nerve myelination...
  69. doi A role for miR-142-3p in colony-stimulating factor 1-induced monocyte differentiation into macrophages
    Brice Lagrange
    Faculte de Medecine, Universite de Bourgogne, Dijon, France
    Biochim Biophys Acta 1833:1936-46. 2013
    ..of the genes whose expression is repressed by miR-142-3p encodes the transcription factor Early Growth Response 2 (Egr2)...
  70. ncbi Gene expression profiling of glucocorticoid-inhibited osteoblasts
    Nathalie Leclerc
    Department of Biochemistry and Molecular Biology, Institute for Genetic Medicine, Keck School of Medicine at the University of Southern California, 2250 Alcazar Street, Los Angeles, California 90033, USA
    J Mol Endocrinol 33:175-93. 2004
    ..Others are shown here for the first time to respond to GCs. DEX strongly repressed Krox20/Egr2 at both the mRNA and the protein level...
  71. pmc Involvement of miR-20a in promoting gastric cancer progression by targeting early growth response 2 (EGR2)
    Xiangsheng Li
    Department of General Surgery, Xinqiao Hospital, Third Military Medical University, Xinqiao Road, Chongqing 400037, China
    Int J Mol Sci 14:16226-39. 2013
    ..Luciferase activity and Western blot confirmed that miR-20a negatively regulated EGR2 expression. Overexpression of EGR2 significantly attenuated the oncogenic effect of miR-20a...
  72. pmc Chronic co-administration of nicotine and methamphetamine causes differential expression of immediate early genes in the dorsal striatum and nucleus accumbens of rats
    F Saint-Preux
    Molecular Neuropsychiatry Research Branch, NIDA IRP, Baltimore, MD 21224, USA
    Neuroscience 243:89-96. 2013
    ..Of the Egr family members, NAc egr2 expression was decreased after nicotine and the drug combination whereas NAc egr3 was decreased after METH and the ..
  73. pmc Paradoxical role of an Egr transcription factor family member, Egr2/Krox20, in learning and memory
    Roseline Poirier
    Laboratoire de Neurobiologie de l Apprentissage, Univ Paris Sud France roseline poirier u psud fr
    Front Behav Neurosci 1:6. 2007
    ..Another Egr family member expressed in brain, Egr2/Krox20 is known to be crucial for normal hindbrain development and has been implicated in several inherited peripheral ..
  74. pmc Egr2::cre mediated conditional ablation of dicer disrupts histogenesis of mammalian central auditory nuclei
    Elena Rosengauer
    Department of Neurogenetics, Carl von Ossietzky University Oldenburg, Oldenburg, Germany
    PLoS ONE 7:e49503. 2012
    ..Here, we investigated their role for the formation of the auditory brainstem. Egr2::Cre-mediated early embryonic ablation of Dicer1 caused severe disruption of auditory brainstem structures...
  75. doi Calcineurin-nuclear factor of activated T cells regulation of Krox-20 expression in Schwann cells requires elevation of intracellular cyclic AMP
    Maulilio J Kipanyula
    Department of Veterinary Anatomy, Sokoine University of Agriculture, Chuo Kikuu, Morogoro, Tanzania
    J Neurosci Res 91:105-15. 2013
    The transcription factor Krox-20 (Egr2) is a master regulator of Schwann cell myelination...
  76. pmc IRES-dependent translation of egr2 is induced under inflammatory conditions
    Daniela Rübsamen
    Institute of Biochemistry I, Goethe University Frankfurt, 60590 Frankfurt, Germany
    RNA 18:1910-20. 2012
    ..Polysome profiling and microarray analysis identified early growth response-2 (egr2) to be regulated at the level of translation...
  77. ncbi In vitro and in vivo differentiation of boundary cap neural crest stem cells into mature Schwann cells
    Jorge B Aquino
    Unit of Molecular Neurobiology MBB, Karolinska Institutet, Scheeles vag 1 A1 2, 171 77 Stockholm, Sweden
    Exp Neurol 198:438-49. 2006
    ..After analysis of the in vivo expression of Sox2, Sox10, S100, GFAP, fibronectin and Krox20 in the glial lineages, we used these markers to characterize differentiation of the bNCSCs...
  78. pmc Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors
    Hozefa S Bandukwala
    La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 109:14532-7. 2012
    ..analysis revealed up-regulated expression of several antiinflammatory gene products, including IL-10, Lag3, and Egr2, and down-regulated expression of several proinflammatory cytokines including GM-CSF and IL-17...
  79. doi Retrocochlear function of the peripheral deafness gene Cacna1d
    Somisetty V Satheesh
    Department of Neurogenetics, Carl von Ossietzky University Oldenburg, 26111 Oldenburg, Germany
    Hum Mol Genet 21:3896-909. 2012
    ..To this end, we generated a mouse conditional Cacna1d-eGFP(flex) allele. Upon pairing with Egr2::Cre mice, Ca(v)1.3 was ablated in the auditory brainstem, leaving the inner ear intact...
  80. pmc Genetic association of the EGR2 gene with bipolar disorder in Korea
    Se Hyun Kim
    Department of Neuropsychiatry, Seoul National University Hospital, Korea
    Exp Mol Med 44:121-9. 2012
    The early growth response gene 2 (EGR2) is located at chromosome 10q21, one of the susceptibility loci in bipolar disorder (BD)...
  81. pmc Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling
    Michael P Seiler
    Committee on Immunology and the Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois, USA
    Nat Immunol 13:264-71. 2012
    ..Here we found that TCR-induced transcription factors Egr2 and Egr1 had higher and more-prolonged expression in precursors of the natural killer T (NKT) than in cells of ..
  82. pmc Distal enhancers upstream of the Charcot-Marie-Tooth type 1A disease gene PMP22
    Erin A Jones
    Program in Cellular and Molecular Biology, University of Wisconsin, Madison, WI 53705, USA
    Hum Mol Genet 21:1581-91. 2012
    ..Using chromatin immunoprecipitation analysis of two transcription factors known to upregulate PMP22-EGR2 and SOX10-we found several enhancers in this upstream region that contain open chromatin and direct reporter gene ..
  83. doi Distinctive features of Egr transcription factor regulation and DNA binding activity in CA1 of the hippocampus in synaptic plasticity and consolidation and reconsolidation of fear memory
    Hélène Cheval
    CNRS, Centre de Neurosciences Paris Sud, UMR 8195, Orsay, F 91405, France
    Hippocampus 22:631-42. 2012
    ..Here, we focused on area CA1 and examined regulation of Egr1, Egr2, and Egr3 mRNA and protein, and their DNA binding activity to the Egr response element (ERE) at different times ..
  84. pmc Serum response factor regulates immediate early host gene expression in Toxoplasma gondii-infected host cells
    Mandi Wiley
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America
    PLoS ONE 6:e18335. 2011
    ..Previous studies demonstrated that genes encoding transcription factors such as c-jun, junB, EGR1, and EGR2 were amongst the host genes that were the most rapidly upregulated following infection...
  85. ncbi Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus
    K M Call
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139
    Cell 60:509-20. 1990
    ..of the predicted polypeptide shows significant homology to two growth regulated mammalian polypeptides, EGR1 and EGR2. The genetic localization of this gene, its tissue-specific expression, and the function predicted from its ..
  86. pmc Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity
    Ashwin Woodhoo
    Department of Cell and Developmental Biology, University College London, UK
    Nat Neurosci 12:839-47. 2009
    ..that myelination is subject to negative transcriptional regulation that opposes forward drives such as Krox20. Notably, in the adult, Notch dysregulation resulted in demyelination; this finding identifies a signaling pathway ..
  87. pmc MicroRNAs modulate Schwann cell response to nerve injury by reinforcing transcriptional silencing of dedifferentiation-related genes
    Andreu Viader
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 31:17358-69. 2011
    ..miR-140 targeted the transcription factor Egr2, a master regulator of myelination, and modulated myelination in DRG/SC cocultures...
  88. doi Redox-sensitive regulation of gene expression in human primary macrophages exposed to inorganic arsenic
    Emilie Bourdonnay
    INSERM U620, Group Toxicité des contaminants de l environnement, 2 Avenue du Pr Leon Bernard, 35043 Rennes, France
    J Cell Biochem 107:537-47. 2009
    ..and Bach1, two redox-sensitive regulators of stress genes, and represses expression of the transcription factor EGR2 which is involved in mouse macrophage differentiation; such effects are reduced by N-acetylcysteine...
  89. ncbi Mutations in the early growth response 2 (EGR2) gene are associated with hereditary myelinopathies
    L E Warner
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Genet 18:382-4. 1998
    ..Egr2, (also known as Krox20) is the mouse orthologue of human EGR2 and was first identified as an immediate-early response gene, encoding a ..
  90. pmc Congenital hypomyelinating neuropathy with lethal conduction failure in mice carrying the Egr2 I268N mutation
    Robert H Baloh
    Department of Neurology, and Hope Center for Neurological Diseases, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 29:2312-21. 2009
    ..Here, we describe the engineering and characterization of a mouse carrying the I268N mutation in Egr2, observed in patients with recessively inherited Charcot-Marie-Tooth (CMT) disease type 4E, which is predicted to ..
  91. ncbi Specification of the hindbrain fate in the zebrafish
    K Woo
    Biological Imaging Center, Beckman Institute, California Institute of Technology, Pasadena 91125, USA
    Dev Biol 197:283-96. 1998
    ..they are able to maintain regional fate, as is evident by the expression of the hindbrain-specific marker, Krox20. In addition, we observe that committed hindbrain tissues are able to induce presumptive ventral epidermis to form ..
  92. doi A functional interaction between Irx and Meis patterns the anterior hindbrain and activates krox20 expression in rhombomere 3
    Aline Stedman
    CNRS UMR7622, Laboratoire de Biologie du Developpement, Universite Pierre et Marie Curie, Bâtiment C 7ème étage, Boite 24, 9 quai Saint Bernard, 75005 Paris, France
    Dev Biol 327:566-77. 2009
    ..and Irx1b, are required for the proper formation and specification of rhombomeres 1 to 4 and, in particular, for krox20 activation in r3...
  93. ncbi Essential role of CREB family proteins during Xenopus embryogenesis
    B Lutz
    Max Planck Institute of Psychiatry, Munich, Germany
    Mech Dev 88:55-66. 1999
    ..initial induction of neural and mesodermal tissues is not dependent on CREB function, as genes such as Otx2, Krox20, Shh and MyoD are still expressed in injected embryos...
  94. doi Age-associated changes in cardiac gene expression after preconditioning
    Lixin Liu
    Department of Anesthesiology, Stony Brook University School of Medicine, New York 11794, USA
    Anesthesiology 111:1052-64. 2009
    ..The authors hypothesized that age would differentially modulate gene expression induced by IPC and APC in vivo...
  95. doi Mkl transcription cofactors regulate structural plasticity in hippocampal neurons
    Niamh C O'Sullivan
    Applied Neurotherapeutics Research Group, UCD Schools of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland
    Cereb Cortex 20:1915-25. 2010
    ..Gene regulation immediately after learning includes Egr2 and may be facilitated by downregulation of Mkls likely releasing ternary complex factor-regulated SRF activity...
  96. pmc DNA-binding specificity of NGFI-A and related zinc finger transcription factors
    A H Swirnoff
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110
    Mol Cell Biol 15:2275-87. 1995
    ..member of a family of immediate-early gene-encoded transcription factors which includes NGFI-C, Egr3, and Krox20. These proteins possess highly homologous DNA-binding domains, composed of three Cys2-His2 zinc fingers, and all ..
  97. doi HDAC1 and HDAC2 control the transcriptional program of myelination and the survival of Schwann cells
    Claire Jacob
    Institute of Cell Biology, Department of Biology, ETH Zurich, Zurich, Switzerland
    Nat Neurosci 14:429-36. 2011
    ..Expression of Sox10 and Krox20, the main transcriptional regulators of Schwann cell myelination, was greatly reduced...
  98. doi Prenatal development of central rhythm generation
    Jean Champagnat
    Neurobiologie et Développement UPR 3294, CNRS, Neuro Sud Paris IFR 144, Centre de Recherche de Gif sur Yvette CNRS, FRC 3115, Gif sur Yvette, France
    Respir Physiol Neurobiol 178:146-55. 2011
    ..and lineages forming each of these oscillators during early development of the neural tube: Hoxa1, Egr2 (Krox20), Phox2b, Lbx1 and Atoh1 for the e-pF; Dbx1 and Evx1 for the preBötC which eventually grow contralateral axons ..
  99. doi Hindbrain patterning requires fine-tuning of early krox20 transcription by Sprouty 4
    Charlotte Labalette
    Ecole Normale Superieure, IBENS, Paris Cedex 75230, France
    Development 138:317-26. 2011
    ..factor (FGF) signalling plays a major role, notably by controlling the expression of the transcription factor Krox20 (Egr2), which is required for the formation and specification of two segmental units: rhombomeres (r) 3 and 5...
  100. pmc Locus-wide identification of Egr2/Krox20 regulatory targets in myelin genes
    Sung Wook Jang
    Program in Cellular and Molecular Biology, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    J Neurochem 115:1409-20. 2010
    ..peripheral nerves by Schwann cells depends upon a gene regulatory network controlled by early growth response Egr2/Krox20, which is specifically required for Schwann cells to initiate and maintain myelination...
  101. ncbi Identification and characterization of early growth response 2, a zinc-finger transcription factor, as a p53-regulated proapoptotic gene
    Ikuko Yokota
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo 060 8556, Japan
    Int J Oncol 37:1407-16. 2010
    ..Using microarray analysis, we have identified the transcription factor early growth response 2 (EGR2) as a target of the p53 family, specifically p53, p63 and p73...

Research Grants64

  1. Genetic control of myelination by EGR2 and NAB proteins
    John Svaren; Fiscal Year: 2006
    ..CHN}-are caused by deficits in myelin formation and maintenance, and mutations in the gene coding for the EGR2 transactivator have recently been associated with these diseases...
  2. Regulation of Monocyte and Granulocyte Lineage Specification
    Alan D Friedman; Fiscal Year: 2010
    ..Microarray studies using an inducible cell line, combined with ChIP data, suggest that the EGR2 promoter is an additional C/EBPa:AP-1 genetic target. Egr-2, like elevated PU.1, favors monopoiesis...
  3. ERK Mitogen Activated Protein Kinases in Skeletogenesis
    Shunichi Murakami; Fiscal Year: 2010
    ..We hypothesize that 1) Krox20 expression is regulated by ERK1/ERK2 through its MAPK response element via DNA binding complex containing direct ..
  4. Genetic control of myelination by EGR2 and NAB proteins
    JOHN P SVAREN; Fiscal Year: 2010
    ..The EGR2/Krox20 transcription factor is a master regulator of the myelination program in peripheral nerve, and human genetics ..
  5. Genetic mechanisms of myelination in zebrafish
    William S Talbot; Fiscal Year: 2010
    ..In addition, we will test the hypothesis that this new transmembrane protein triggers myelination by activating krox20 in Schwann cells...
  6. CMT Peripheral Neuropathy: IV. Genes and Pathogenesis
    JAMES LUPSKI; Fiscal Year: 2005
    ..nerve structure/function and maintenance; (ii) genes that are downstream targets of the transcription factor EGR2 are important candidates for inherited peripheral nerve disease; (iii) structural features of the human genome may ..
  7. Genetic control of myelination by EGR2 and NAB proteins
    JOHN P SVAREN; Fiscal Year: 2010
    ..The EGR2/Krox20 transcription factor is a master regulator of the myelination program in peripheral nerve, and human genetics ..
  8. p21-Activated Kinases as New Therapeutic Targets in Neurofibromatosis Type 1
    JONATHAN D CHERNOFF; Fiscal Year: 2010
    ..if loss of Pak function reverses the activation of MAPK and cytoskeletal alterations in vitro;and 3) We will cross Krox20-cre/Nf1flox/- mice, which develop malignant peripheral nerve sheath tumors, with Pak1 knock out mice, or ..
  9. Hindbrain Dysgenesis in Rett Syndrome and Other Autism-Spectrum Disorders
    Susan Swanberg; Fiscal Year: 2007
    ..Genes which are involved in the process of hindbrain development include Homeobox genes of the Hox family and EGR2. Hoxa1 and EGR2 interact syngergistically in a dosage- dependent manner to partition portions of the ..
  10. Regulation of Myelination by Egr2/Nab Protein Complexes
    Jeffrey Milbrandt; Fiscal Year: 2009
    The discovery that Egr2-deficient mice have hypomyelinated peripheral nerves led to the realization that EGR2 is an essential regulator of the Schwann cell myelination program and, moreover, to the identification of EGR2 mutations in ..
  11. Regulation of Myelination by Egr2/Nab Protein Complexes
    Jeffrey Milbrandt; Fiscal Year: 2007
    The discovery that Egr2-deficient mice have hypomyelinated peripheral nerves led to the realization that EGR2 is an essential regulator of the Schwann cell myelination program and, moreover, to the identification of EGR2 mutations in ..
  12. Generation of Respiratory Rhythm
    JACK FELDMAN; Fiscal Year: 2007
    ..We will look at mice (Krox20) with genetically-induced brainstem developmental anomalies that affect the RTN/pFRG...
  13. Generation of Respiratory Rhythm
    Jack L Feldman; Fiscal Year: 2010
    ..We will look at mice (Krox20) with genetically-induced brainstem developmental anomalies that affect the RTN/pFRG...
  14. Regulation of Monocyte and Granulocyte Lineage Specification
    Alan D Friedman; Fiscal Year: 2011
    ..Microarray studies using an inducible cell line, combined with ChIP data, suggest that the EGR2 promoter is an additional C/EBPa:AP-1 genetic target. Egr-2, like elevated PU.1, favors monopoiesis...
  15. The role of microRNAs in Schwann cell development and disease
    RAJESHWAR BHAGWAN AWATRAMANI; Fiscal Year: 2010
    ..transition, maintain the expression of Sox2, and lack the SC master regulator gene Egr2 (Krox20)...
  16. KROX 20 AND BONE MASS
    Baruch Frenkel; Fiscal Year: 2007
    b>Krox20 and Bone Mass. We propose to delineate the role of the transcription factor Krox20 in the regulation of osteoblast function and bone mass control...
  17. KROX 20 AND BONE MASS
    Baruch Frenkel; Fiscal Year: 2009
    b>Krox20 and Bone Mass. We propose to delineate the role of the transcription factor Krox20 in the regulation of osteoblast function and bone mass control...
  18. KROX 20 AND BONE MASS
    Baruch Frenkel; Fiscal Year: 2010
    b>Krox20 and Bone Mass. We propose to delineate the role of the transcription factor Krox20 in the regulation of osteoblast function and bone mass control...
  19. ROLE OF EGR2 MUTATIONS IN PERIPHERAL MYELINOPATHIES
    Jeffrey Milbrandt; Fiscal Year: 2005
    ..Recently, however, mutations in the transcription factor Egr2 have also been associated with these syndromes...
  20. DGK in T Cell Regulation and Tolerance
    Thomas F Gajewski; Fiscal Year: 2010
    ..be analyzed functionally using adenoviral vectors and CAR the second specific aim, the functional adenoviruses for EGR2 expression, and a Cre adenovirus for conditional deletion of EGR2 in employed using the CAR Tg system...
  21. INTERACTION OF LEAD WITH ZINC FINGER PROTEINS
    Nasser Zawia; Fiscal Year: 2002
    ..are to study the effects of lead exposure on the DNA binding properties of zinc finger proteins (zif268, SP1, and krox20) and to examine if their functional capacity of gene activation/deactivation is impaired by lead...