EGF

Summary

Gene Symbol: EGF
Description: epidermal growth factor
Alias: HOMG4, URG, pro-epidermal growth factor, beta-urogastrone
Species: human
Products:     EGF

Top Publications

  1. Bao G, Wang M, Guo S, Han Y, Xu G. Association between epidermal growth factor +61 G/A polymorphism and glioma risk in a Chinese Han population. J Int Med Res. 2010;38:1645-52 pubmed
    The association between the +61 G/A polymorphism of the epidermal growth factor (EGF) gene and glioma risk remains controversial and unclear...
  2. Kovar F, Thallinger C, Marsik C, Perkmann T, Puhalla H, Haslacher H, et al. The EGF 61A/G polymorphism - a predictive marker for recurrence of liver metastases from colorectal cancer. Wien Klin Wochenschr. 2009;121:638-43 pubmed publisher
    Epidermal growth factor (EGF) plays an important role in tumorigenesis. Variations in the DNA sequence of the gene EGF can lead to alterations in EGF activity, which is suspected to influence tumor progression...
  3. Goto Y, Ando T, Goto H, Hamajima N. No association between EGF gene polymorphism and gastric cancer. Cancer Epidemiol Biomarkers Prev. 2005;14:2454-6 pubmed
    The etiology of gastric cancer is not well-understood. Epidermal growth factor (EGF) transduces growth signals to mitogen-activated protein kinase via RAS and BRAF, and EGF/EGF receptor interaction is important for tumor growth and ..
  4. Casula M, Alaibac M, Pizzichetta M, Bono R, Ascierto P, Stanganelli I, et al. Role of the EGF +61A>G polymorphism in melanoma pathogenesis: an experience on a large series of Italian cases and controls. BMC Dermatol. 2009;9:7 pubmed publisher
    A single nucleotide polymorphism (61A>G) in the epidermal growth factor (EGF) gene has been implicated in both melanoma pathogenesis and increased melanoma risk...
  5. Tan D, Xu J, Li Y, Lai R. Association between +61G polymorphism of the EGF gene and glioma risk in different ethnicities: a meta-analysis. Tohoku J Exp Med. 2010;222:229-35 pubmed
    Epidermal growth factor (EGF) plays a key role in survival of neural and glial precursor cells...
  6. Vishnoi M, Pandey S, Modi D, Kumar A, Mittal B. Genetic susceptibility of epidermal growth factor +61A>G and transforming growth factor beta1 -509C>T gene polymorphisms with gallbladder cancer. Hum Immunol. 2008;69:360-7 pubmed publisher
    Epidermal growth factor (EGF) and transforming growth factor beta1 (TGFbeta1) play important roles in tumor biology...
  7. Hamai Y, Matsumura S, Matsusaki K, Kitadai Y, Yoshida K, Yamaguchi Y, et al. A single nucleotide polymorphism in the 5' untranslated region of the EGF gene is associated with occurrence and malignant progression of gastric cancer. Pathobiology. 2005;72:133-8 pubmed
    Epidermal growth factor (EGF) has many biological functions and plays an important role in the progression of various tumors including gastric cancer...
  8. Costa B, Ferreira P, Costa S, Canedo P, Oliveira P, Silva A, et al. Association between functional EGF+61 polymorphism and glioma risk. Clin Cancer Res. 2007;13:2621-6 pubmed
    Epidermal growth factor (EGF) plays a critical role in cancer. A polymorphism in the EGF gene (EGF+61) may influence its expression and contribute to cancer predisposition and aggressiveness...
  9. Li Y, Zhao Y, Liu J, Liu P, Xu Y. A functional polymorphism in the epidermal growth factor gene is associated with risk for glioma in a Chinese population. Genet Test Mol Biomarkers. 2012;16:449-52 pubmed publisher
    Epidermal growth factor (EGF) plays a key role in survival of neural and glial precursor cells...

More Information

Publications65

  1. Feng Y, Dai X, Li X, Wang H, Liu J, Zhang J, et al. EGF signalling pathway regulates colon cancer stem cell proliferation and apoptosis. Cell Prolif. 2012;45:413-9 pubmed publisher
    ..Growth factors such as epidermal growth factor (EGF) and basic fibroblast growth factor (b-FGF) promote cancer stem cell proliferation in many solid tumours...
  2. Li Y, Xie Q, Lu F, Zhao J, Mao P, Li Z, et al. Association between epidermal growth factor 61A/G polymorphism and hepatocellular carcinoma susceptibility in Chinese patients. Liver Int. 2010;30:112-8 pubmed publisher
    ..The epidermal growth factor (EGF) pathway plays an important role in tumorigenesis, including HCC...
  3. Spindler K, Nielsen J, Ornskov D, Brandslund I, Jakobsen A. Epidermal growth factor (EGF) A61G polymorphism and EGF gene expression in normal colon tissue from patients with colorectal cancer. Acta Oncol. 2007;46:1113-7 pubmed
    b>EGF/EGFR interactions are important mechanisms behind colorectal tumour development and growth. Recently a single nucleotide polymorphism in the EGF gene has been identified (EGF A61G)...
  4. Jain M, Kumar S, Upadhyay R, Lal P, Tiwari A, Ghoshal U, et al. Influence of apoptosis (BCL2, FAS), cell cycle (CCND1) and growth factor (EGF, EGFR) genetic polymorphisms on survival outcome: an exploratory study in squamous cell esophageal cancer. Cancer Biol Ther. 2007;6:1553-8 pubmed
    The study aimed at investigating whether genetic polymorphisms in BCL2, FAS, CCND1, EGF and EGFR genes influence the outcome of patients of esophageal squamous cell cancer treated with radiotherapy, with or without chemotherapy...
  5. Liu X, Li L, Chen X, Wang X, Mu L, Li Y, et al. No association between EGF +61 A/G polymorphism and increased risk of glioma. Int J Biol Markers. 2009;24:77-82 pubmed
    A single nucleotide polymorphism (SNP) of the epidermal growth factor (EGF) gene +61 A/G in the 5'-untranslated region has been reported to be associated with susceptibility to glioma...
  6. LaMarca H, Dash P, Vishnuthevan K, Harvey E, Sullivan D, Morris C, et al. Epidermal growth factor-stimulated extravillous cytotrophoblast motility is mediated by the activation of PI3-K, Akt and both p38 and p42/44 mitogen-activated protein kinases. Hum Reprod. 2008;23:1733-41 pubmed publisher
    ..Evidence suggests that the potent mitogen epidermal growth factor (EGF) regulates cytotrophoblast (CTB) differentiation and invasion during early pregnancy...
  7. Li T, Ren K, Liu P. Meta-analysis of epidermal growth factor polymorphisms and cancer risk: involving 9,779 cases and 15,932 controls. DNA Cell Biol. 2012;31:568-74 pubmed publisher
    The epidermal growth factor (EGF) pathway stimulates proliferation and differentiation of epidermal and epithelial tissues, and plays an important role in tumorigenesis...
  8. Xu X, Xi L, Zeng J, Yao Q. A functional +61G/A polymorphism in epidermal growth factor is associated with glioma risk among Asians. PLoS ONE. 2012;7:e41470 pubmed publisher
    Epidermal growth factor (EGF), a potent mitogenic protein, plays an important role in the development of cancers, including glioma...
  9. Kang S, Kim J, Park N, Song Y, Park S, Kang S, et al. Epidermal growth factor 61 A/G polymorphism and uterine cervical cancer. Int J Gynecol Cancer. 2007;17:492-6 pubmed
    ..we hypothesized that a functional polymorphism in the 5' untranslated region of the epidermal growth factor (EGF) gene, a natural ligand of the EGFR, may play a role in the cervical carcinogenesis and tumor invasiveness...
  10. Jin G, Miao R, Deng Y, Hu Z, Zhou Y, Tan Y, et al. Variant genotypes and haplotypes of the epidermal growth factor gene promoter are associated with a decreased risk of gastric cancer in a high-risk Chinese population. Cancer Sci. 2007;98:864-8 pubmed
    Epidermal growth factor (EGF), a ligand of the EGF receptor, plays a critical role in the development of gastric cancer...
  11. Zhong J, You X, Gong W, Ma L, Zhang Y, Mo Q, et al. Epidermal growth factor gene polymorphism and risk of hepatocellular carcinoma: a meta-analysis. PLoS ONE. 2012;7:e32159 pubmed publisher
    ..is a complex process that may be influenced by many factors, including polymorphism in the epidermal growth factor (EGF) gene...
  12. Kim J, Kushiro K, Graham N, Asthagiri A. Tunable interplay between epidermal growth factor and cell-cell contact governs the spatial dynamics of epithelial growth. Proc Natl Acad Sci U S A. 2009;106:11149-53 pubmed publisher
    ..cells quantitatively reconcile the opposing effects of cell-cell contact and GFs, such as epidermal growth factor (EGF), remains unclear...
  13. Cui L, Pan X, Ma C, Shang Guan J, Yu H, Chen G, et al. Association between epidermal growth factor polymorphism and esophageal squamous cell carcinoma susceptibility. Dig Dis Sci. 2010;55:40-5 pubmed publisher
    ..Epidermal growth factor (EGF) can activate several signaling pathways leading to proliferation, differentiation, and tumorigenesis of epithelial ..
  14. Zhang Y, Cao C, Liang K. Genetic polymorphism of epidermal growth factor 61A>G and cancer risk: a meta-analysis. Cancer Epidemiol. 2010;34:150-6 pubmed publisher
    Numerous studies have investigated the risk of cancer associated with the polymorphism of epidermal growth factor (EGF) 61A>G, but the results have been inconsistent...
  15. Lemos González Y, Rodriguez Berrocal F, Cordero O, Gomez C, Paez de la Cadena M. Alteration of the serum levels of the epidermal growth factor receptor and its ligands in patients with non-small cell lung cancer and head and neck carcinoma. Br J Cancer. 2007;96:1569-78 pubmed
    Serum levels of the soluble epidermal growth factor receptor (sEGFR) and its ligands epidermal growth factor (EGF), transforming growth factor-alpha (TGF-alpha) and amphiregulin (AR) were measured in healthy donors and patients with non-..
  16. Vauleon E, Auger N, Benouaich Amiel A, Laigle Donadey F, Kaloshi G, Lejeune J, et al. The 61 A/G EGF polymorphism is functional but is neither a prognostic marker nor a risk factor for glioblastoma. Cancer Genet Cytogenet. 2007;172:33-7 pubmed
    The A/G61 polymorphism located in the 5'UTR of the EGF gene has been found to be both a risk factor and a prognostic factor in glioblastoma (GBM), but the functional consequences have not been investigated...
  17. Einarsdóttir K, Darabi H, Li Y, Low Y, Li Y, Bonnard C, et al. ESR1 and EGF genetic variation in relation to breast cancer risk and survival. Breast Cancer Res. 2008;10:R15 pubmed publisher
    ..of oestrogen effect in breast epithelia and has also been shown to be activated by epidermal growth factor (EGF)...
  18. Araújo A, Ribeiro R, Pereira D, Pinto D, Sousa B, Catarino R, et al. Ovarian cancer and genetic susceptibility: association of A61G polymorphism in the EGF gene. Exp Biol Med (Maywood). 2009;234:241-5 pubmed publisher
    ..The epidermal growth factor (EGF) gene codifies a growth factor that binds to the EGF receptor (EGFR), which is involved in activating pathways that ..
  19. Pinto G, Yoshioka F, Clara C, Santos M, Almeida J, Burbano R, et al. Association study of an epidermal growth factor gene functional polymorphism with the risk and prognosis of gliomas in Brazil. Int J Biol Markers. 2009;24:277-81 pubmed
    Epidermal growth factor (EGF) plays an important role in cancer...
  20. Xu W, Li Y, Wang X, Chen B, Liu S, Wang Y, et al. Association between EGF promoter polymorphisms and cancer risk: a meta-analysis. Med Oncol. 2010;27:1389-97 pubmed publisher
    b>EGF promoter polymorphisms are observed to modulate EGF levels and thought to have effect on susceptibility to various carcinomas but the results are inconsistent...
  21. Araújo A, Ribeiro R, Pinto D, Pereira D, Sousa B, Mauricio J, et al. Epidermal growth factor genetic variation, breast cancer risk, and waiting time to onset of disease. DNA Cell Biol. 2009;28:265-9 pubmed publisher
    ..One of the most important is the epidermal growth factor (EGF), which is encoded by EGF gene...
  22. Muthusamy K, Lian L, Vairavan N, Chua K, Waran V. Genetic polymorphisms of EGF 5'-UTR and NAT2 857G/A associated with glioma in a case control study of Malaysian patients. Genet Mol Res. 2012;11:2939-45 pubmed
    ..Epidermal growth factor (EGF) and the NAT2 gene play a central role in carcinogenesis...
  23. Okamoto I, Roka F, Krögler J, Endler G, Kaufmann S, Tockner S, et al. The EGF A61G polymorphism is associated with disease-free period and survival in malignant melanoma. J Invest Dermatol. 2006;126:2242-6 pubmed
    An earlier study reported that a common polymorphism in the 5' untranslated region of the epidermal growth factor (EGF) gene is associated with increased risk for cutaneous malignant melanoma (MM) and Breslow thickness...
  24. Kang H, Choi J, Lee W, Kam S, Cha S, Kim C, et al. +61A>G polymorphism in the EGF gene does not increase the risk of lung cancer. Respirology. 2007;12:902-5 pubmed
    Epidermal growth factor (EGF) plays an important role in tumourigenesis by binding with its receptor, EGFR...
  25. Upadhyay R, Jain M, Kumar S, Ghoshal U, Mittal B. Interaction of EGFR 497Arg>Lys with EGF +61A>G polymorphism: modulation of risk in esophageal cancer. Oncol Res. 2008;17:167-74 pubmed
    Genetic polymorphisms in EGFR 497Arg>Lys and EGF +61A>G genes influence cell cycle progression, apoptosis, angiogenesis, and metastasis...
  26. Wang S, Zhao Y, Ruan Z, Chen H, Fan W, Chen J, et al. Association between EGF +61 G/A and glioma risk in a Chinese population. BMC Cancer. 2010;10:221 pubmed publisher
    Epidermal growth factor (EGF) is critical in cancer process. EGF and EGF receptor (EGFR) interaction plays a pivotal role in cell proliferation, differentiation, and tumorigenesis of epithelial tissues...
  27. Cheng J, Auersperg N, Leung P. EGF-induced EMT and invasiveness in serous borderline ovarian tumor cells: a possible step in the transition to low-grade serous carcinoma cells?. PLoS ONE. 2012;7:e34071 pubmed publisher
    In high-grade ovarian cancer cultures, it has been shown that epidermal growth factor (EGF) induces cell invasion by activating an epithelial-mesenchymal transition (EMT)...
  28. Orlichenko L, Huang B, Krueger E, McNiven M. Epithelial growth factor-induced phosphorylation of caveolin 1 at tyrosine 14 stimulates caveolae formation in epithelial cells. J Biol Chem. 2006;281:4570-9 pubmed
    ..In this study we report that stimulation of epithelial cells with epithelial growth factor (EGF) results in a profound increase in the number of caveolar structures at the plasma membrane...
  29. Qi P, Wang H, Chen Y, Sun X, Liu Y, Gao C. No association of EGF 5'UTR variant A61G and hepatocellular carcinoma in Chinese patients with chronic hepatitis B virus infection. Pathology. 2009;41:555-60 pubmed
    Epidermal growth factor (EGF) has many biological functions, including mitogenesis, tumorigenesis, and proliferation of epidermal tissues...
  30. Chen K, Wei Y, Yang H, Li B. Epidermal growth factor +61 G/A polymorphism and the risk of hepatocellular carcinoma in a Chinese population. Genet Test Mol Biomarkers. 2011;15:251-5 pubmed publisher
    ..Epidermal growth factor (EGF) plays an important role in tumorigenesis...
  31. da Silveira F, Lopes B, da Fonseca C, Quirico Santos T, de Palmer Paixão I, de Amorim L. Analysis of EGF+61A>G polymorphism and EGF serum levels in Brazilian glioma patients treated with perillyl alcohol-based therapy. J Cancer Res Clin Oncol. 2012;138:1347-54 pubmed publisher
    Malignant gliomas are associated with alteration in EGF/EGFR signaling. Functional EGF+61A>G polymorphism is implicated with risk, recurrence, and progression of glioma...
  32. Suzuki A, Sekiya S, Gunshima E, Fujii S, Taniguchi H. EGF signaling activates proliferation and blocks apoptosis of mouse and human intestinal stem/progenitor cells in long-term monolayer cell culture. Lab Invest. 2010;90:1425-36 pubmed publisher
    ..Although epidermal growth factor (EGF) is conventionally used as a supplement of intestinal epithelial cell culture, little has been known regarding a ..
  33. Wang Y, Tian T, Hu Z, Tang J, Wang S, Wang X, et al. EGF promoter SNPs, plasma EGF levels and risk of breast cancer in Chinese women. Breast Cancer Res Treat. 2008;111:321-7 pubmed
    Epidermal growth factor (EGF), a potent mitogenic peptide, plays an important role in the development of cancers, including breast cancer. Previous studies showed that plasma EGF levels may influence the risk of cancer...
  34. Uddin M, Seumois G, Lau L, Rytila P, Davies D, Djukanovic R. Enhancement of neutrophil function by the bronchial epithelium stimulated by epidermal growth factor. Eur Respir J. 2008;31:714-24 pubmed
    ..study was to elucidate the mechanisms whereby the bronchial epithelium, stimulated by epidermal growth factor (EGF) as part of a response to acute or chronic injury, could activate and chemoattract human neutrophils...
  35. Cmet S, Fabris C, Fattovich G, Falleti E, Bitetto D, Cussigh A, et al. Carriage of the EGF rs4444903 A>G functional polymorphism associates with disease progression in chronic HBV infection. Clin Exp Immunol. 2012;167:296-302 pubmed publisher
    Because epidermal growth factor (EGF) up-regulation is characteristic of the cirrhotic liver, we hypothesised that the EGF rs4444903 A > G functional polymorphism might be associated with a worse disease course in patients with ..
  36. Tanabe K, Lemoine A, Finkelstein D, Kawasaki H, Fujii T, Chung R, et al. Epidermal growth factor gene functional polymorphism and the risk of hepatocellular carcinoma in patients with cirrhosis. JAMA. 2008;299:53-60 pubmed publisher
    Overexpression of epidermal growth factor (EGF) in the liver induces transformation to hepatocellular carcinoma in animal models. Polymorphisms in the EGF gene modulate EGF levels...
  37. Lanuti M, Liu G, Goodwin J, Zhai R, Fuchs B, Asomaning K, et al. A functional epidermal growth factor (EGF) polymorphism, EGF serum levels, and esophageal adenocarcinoma risk and outcome. Clin Cancer Res. 2008;14:3216-22 pubmed publisher
    The epidermal growth factor (EGF) pathway is important in esophageal adenocarcinoma (EAC) tumorigenesis...
  38. Gao L, Wei Y, Zhou B, Wang Y, Liang W, Li C, et al. No association between epidermal growth factor and epidermal growth factor receptor polymorphisms and nasopharyngeal carcinoma. Cancer Genet Cytogenet. 2008;185:69-73 pubmed publisher
    ..Epidermal growth factor (EGF) and epidermal growth factor receptor (EGFR) interaction plays a pivotal role in cell proliferation, ..
  39. Waterman H, Katz M, Rubin C, Shtiegman K, Lavi S, Elson A, et al. A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling. EMBO J. 2002;21:303-13 pubmed
    ..here we report that defective Tyr1045 of EGFR, an inducible c-Cbl docking site, enhances the mitogenic response to EGF. Signaling potentiation is due to accelerated recycling of the mutant receptor and a concomitant defect in ligand-..
  40. Shahbazi M, Pravica V, Nasreen N, Fakhoury H, Fryer A, Strange R, et al. Association between functional polymorphism in EGF gene and malignant melanoma. Lancet. 2002;359:397-401 pubmed
    ..relevant to wound healing, tumorigenesis, and proliferation of epidermal tissues, epidermal growth factor (EGF) is an attractive candidate in which to look for genetic polymorphisms...
  41. James M, Hayward N, Dumenil T, Montgomery G, Martin N, Duffy D. Epidermal growth factor gene (EGF) polymorphism and risk of melanocytic neoplasia. J Invest Dermatol. 2004;123:760-2 pubmed
    A common single nucleotide polymorphism (SNP) in the 5' untranslated region (5'UTR) of the epidermal growth factor (EGF) gene modulates the level of transcription of this gene and hence is associated with serum levels of EGF...
  42. Futamura T, Toyooka K, Iritani S, Niizato K, Nakamura R, Tsuchiya K, et al. Abnormal expression of epidermal growth factor and its receptor in the forebrain and serum of schizophrenic patients. Mol Psychiatry. 2002;7:673-82 pubmed
    Epidermal growth factor (EGF) comprises a structurally related family of proteins containing heparin-binding EGF-like growth factor (HB-EGF) and transforming growth factor alpha (TGFalpha) that regulates the development of dopaminergic ..
  43. McCarron S, Bateman A, Theaker J, Howell W. EGF +61 gene polymorphism and susceptibility to and prognostic markers in cutaneous malignant melanoma. Int J Cancer. 2003;107:673-5 pubmed
    ..A striking association between EGF polymorphism and Breslow thickness of invasive CMM has been reported...
  44. Randerson Moor J, Gaut R, Turner F, Whitaker L, Barrett J, Silva I, et al. The relationship between the epidermal growth factor (EGF) 5'UTR variant A61G and melanoma/nevus susceptibility. J Invest Dermatol. 2004;123:755-9 pubmed
    The inheritance of a G allele in position 61 in the 5'UTR of the epidermal growth factor (EGF) gene has been reported to increase melanoma susceptibility, a finding we have investigated in this study...
  45. Lim Y, Kim J, Song J, Hong M, Jin S, Yoon S, et al. Epidermal growth factor gene polymorphism is different between schizophrenia and lung cancer patients in Korean population. Neurosci Lett. 2005;374:157-60 pubmed
    ..Epidermal growth factor (EGF), one of the potent growth promoting factors, has been studied for its roles in cancer development...
  46. Watanabe Y, Fukui N, Muratake T, Kaneko N, Someya T. No association of EGF polymorphism with schizophrenia in a Japanese population. Neuroreport. 2005;16:403-5 pubmed
    Epidermal growth factor (EGF) signal regulates the development of dopaminergic neurons and monoamine metabolism. It is suggested that EGF protein levels are decreased in the brain and blood of patients with schizophrenia...
  47. Amend K, Elder J, Tomsho L, Bonner J, Johnson T, Schwartz J, et al. EGF gene polymorphism and the risk of incident primary melanoma. Cancer Res. 2004;64:2668-72 pubmed
    Overexpression of the epidermal growth factor (EGF) pathway has been implicated in melanoma pathogenesis, and a recent case-control study identified a single nucleotide polymorphism (G to A) in the EGF gene where the G allele was ..
  48. Anttila S, Illi A, Kampman O, Mattila K, Lehtimaki T, Leinonen E. Association of EGF polymorphism with schizophrenia in Finnish men. Neuroreport. 2004;15:1215-8 pubmed
    Some recent data suggest that epidermal growth factor (EGF) protein levels are altered in the brain of schizophrenic patients. In addition, a novel polymorphism of the EGF gene is associated with enhanced production of EGF in vitro...
  49. Morton C, Byers M, Nakai H, Bell G, Shows T. Human genes for insulin-like growth factors I and II and epidermal growth factor are located on 12q22----q24.1, 11p15, and 4q25----q27, respectively. Cytogenet Cell Genet. 1986;41:245-9 pubmed
    ..The genes coding for insulin-like growth factors I and II and epidermal growth factor have been localized to human chromosomes 12q22----q24.1, 11p15, and 4q25----q27, respectively. ..
  50. Bell G, Fong N, Stempien M, Wormsted M, Caput D, Ku L, et al. Human epidermal growth factor precursor: cDNA sequence, expression in vitro and gene organization. Nucleic Acids Res. 1986;14:8427-46 pubmed
    Complementary DNA clones encoding the human kidney epidermal growth factor (EGF) precursor have been isolated and sequenced...
  51. Lurje G, Leers J, Pohl A, Oezcelik A, Zhang W, Ayazi S, et al. Genetic variations in angiogenesis pathway genes predict tumor recurrence in localized adenocarcinoma of the esophagus. Ann Surg. 2010;251:857-64 pubmed publisher
    ..Proteinase-activated-receptor 1 (PAR-1) and epidermal growth factor (EGF) have been shown to mediate the regulation of local and early-onset angiogenesis, and in turn may impact the ..
  52. Han X, Zha Z, Yuan H, Feng X, Xia Y, Lei Q, et al. KDM2B/FBXL10 targets c-Fos for ubiquitylation and degradation in response to mitogenic stimulation. Oncogene. 2016;35:4179-90 pubmed publisher
    ..of other SCF (SKP1-CUL1-F-box)/CRL1 substrates that promotes substrates binding to F-box, epidermal growth factor (EGF)-induced c-Fos S374 phosphorylation dissociates c-Fos from KDM2B and stabilizes c-Fos protein...
  53. Sahin M, El H. External Validation and Evaluation of Reliability of the FARP2 Score to Predict Early Graft Failure after Infrainguinal Bypass. Ann Vasc Surg. 2018;51:72-77 pubmed publisher
    ..A], Redo bypass [R], and Pedal bypass [P2]) scoring system in predicting early graft failure (EGF) after infrainguinal bypass surgery (IBS)...
  54. Sun S, Jin G, Zhao Y, Kang H. Association between the epidermal growth factor 61*A/G polymorphism and hepatocellular carcinoma risk: a meta-analysis. Asian Pac J Cancer Prev. 2015;16:3009-14 pubmed
    The epidermal growth factor (EGF) may play a pathological role in hepatocellular carcinoma (HCC). However, the conclusions of published reports on the relationship between the EGF 61*A/G polymorphism and HCC risk remain controversial...
  55. Séry Q, Rabé M, Oliver L, Vallette F, Gratas C. HB-EGF is associated with DNA damage and Mcl-1 turnover in human glioma cell lines treated by Temozolomide. Biochem Biophys Res Commun. 2017;493:1377-1383 pubmed publisher
    ..of EGFR ligands in this resistance and we found that the pro Heparin Binding Epidermal Growth Factor (proHB-EGF) expression is linked to the early response to TMZ in human glioma cell lines...
  56. Eden G, Archinti M, Arnaudova R, Andreotti G, Motta A, Furlan F, et al. D2A sequence of the urokinase receptor induces cell growth through αvβ3 integrin and EGFR. Cell Mol Life Sci. 2018;75:1889-1907 pubmed publisher
    ..D2A peptide is as effective as EGF in promoting EGFR phosphorylation and cell proliferation that were inhibited by AG1478, a specific inhibitor of the ..