EFNB1

Summary

Gene Symbol: EFNB1
Description: ephrin B1
Alias: CFND, CFNS, EFB1, EFL3, EPLG2, Elk-L, LERK2, ephrin-B1, ELK ligand, eph-related receptor tyrosine kinase ligand 2
Species: human
Products:     EFNB1

Top Publications

  1. Wilkinson D. Multiple roles of EPH receptors and ephrins in neural development. Nat Rev Neurosci. 2001;2:155-64 pubmed
    ..Eph receptor tyrosine kinases and their ephrin ligands are key players in controlling these cell movements in many tissues and at multiple stages of patterning. ..
  2. Compagni A, Logan M, Klein R, Adams R. Control of skeletal patterning by ephrinB1-EphB interactions. Dev Cell. 2003;5:217-30 pubmed
    ..Our findings suggest that differential cell adhesion and sorting might be relevant for an unusual class of X-linked human genetic disorders, in which heterozygous females show more severe phenotypes than hemizygous males. ..
  3. Wieland I, Jakubiczka S, Muschke P, Cohen M, Thiele H, Gerlach K, et al. Mutations of the ephrin-B1 gene cause craniofrontonasal syndrome. Am J Hum Genet. 2004;74:1209-15 pubmed
    ..Recently, we have mapped a gene for CFNS in the pericentromeric region of the X chromosome that contains the EFNB1 gene, which encodes the ephrin-B1 ligand for Eph receptors...
  4. Cowan C, Henkemeyer M. The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals. Nature. 2001;413:174-9 pubmed
    ..These data provide a biochemical pathway whereby cytoskeletal regulators are recruited to Eph-ephrin bidirectional signalling complexes. ..
  5. Shotelersuk V, Siriwan P, Ausavarat S. A novel mutation in EFNB1, probably with a dominant negative effect, underlying craniofrontonasal syndrome. Cleft Palate Craniofac J. 2006;43:152-4 pubmed
    ..Very recently, CFNS was shown to be caused by mutations in EFNB1 encoding ephrin-B1, and 20 mutations have been described...
  6. Wieland I, Makarov R, Reardon W, Tinschert S, Goldenberg A, Thierry P, et al. Dissecting the molecular mechanisms in craniofrontonasal syndrome: differential mRNA expression of mutant EFNB1 and the cellular mosaic. Eur J Hum Genet. 2008;16:184-91 pubmed
    ..is an X-linked malformation syndrome with variable phenotype that is caused by mutations in the ephrin-B1 gene (EFNB1)...
  7. Vermeer P, Bell M, Lee K, Vermeer D, Wieking B, Bilal E, et al. ErbB2, EphrinB1, Src kinase and PTPN13 signaling complex regulates MAP kinase signaling in human cancers. PLoS ONE. 2012;7:e30447 pubmed publisher
  8. Lu Q, Sun E, Klein R, Flanagan J. Ephrin-B reverse signaling is mediated by a novel PDZ-RGS protein and selectively inhibits G protein-coupled chemoattraction. Cell. 2001;105:69-79 pubmed
    ..This study reveals a pathway that links reverse signaling to cellular guidance, uncovers a novel mode of control for G proteins, and demonstrates a mechanism for selective regulation of responsiveness to neuronal guidance cues. ..
  9. Twigg S, Kan R, Babbs C, Bochukova E, Robertson S, Wall S, et al. Mutations of ephrin-B1 (EFNB1), a marker of tissue boundary formation, cause craniofrontonasal syndrome. Proc Natl Acad Sci U S A. 2004;101:8652-7 pubmed
    ..Here, we show that the classical female CFNS phenotype is caused by heterozygous loss-of-function mutations in EFNB1, which encodes a member of the ephrin family of transmembrane ligands for Eph receptor tyrosine kinases...

More Information

Publications102 found, 100 shown here

  1. Wieland I, Reardon W, Jakubiczka S, Franco B, Kress W, Vincent Delorme C, et al. Twenty-six novel EFNB1 mutations in familial and sporadic craniofrontonasal syndrome (CFNS). Hum Mutat. 2005;26:113-8 pubmed
    ..Mutations in the EFNB1 gene in Xq12 are responsible for familial and sporadic CFNS...
  2. Makarov R, Steiner B, Gucev Z, Tasic V, Wieacker P, Wieland I. The impact of CFNS-causing EFNB1 mutations on ephrin-B1 function. BMC Med Genet. 2010;11:98 pubmed publisher
    Mutations of EFNB1 cause the X-linked malformation syndrome craniofrontonasal syndrome (CFNS)...
  3. Vermeer P, Colbert P, Wieking B, Vermeer D, Lee J. Targeting ERBB receptors shifts their partners and triggers persistent ERK signaling through a novel ERBB/EFNB1 complex. Cancer Res. 2013;73:5787-97 pubmed publisher
    ..Here, we describe a novel interaction between EGFR and the ligand EphrinB1 (EFNB1), and we show that EFNB1 phosphorylation and downstream signaling persists in the presence of cetuximab...
  4. Arvanitis D, Jungas T, Behar A, Davy A. Ephrin-B1 reverse signaling controls a posttranscriptional feedback mechanism via miR-124. Mol Cell Biol. 2010;30:2508-17 pubmed publisher
    ..We observed that the EfnB1 3' untranslated region (3'-UTR) confers instability to mRNA transcripts, and we identified miR-124 as a ..
  5. Srisupundit K, Brady P, Devriendt K, Fryns J, Cruz Martinez R, Gratacos E, et al. Targeted array comparative genomic hybridisation (array CGH) identifies genomic imbalances associated with isolated congenital diaphragmatic hernia (CDH). Prenat Diagn. 2010;30:1198-206 pubmed publisher
    ..3, 14.2 Mb in size, a 340 kb duplication of Xq13.1 including the ephrin-B1 gene (EFNB1), and mosaicism for trisomy 2...
  6. Babbs C, Stewart H, Williams L, Connell L, Goriely A, Twigg S, et al. Duplication of the EFNB1 gene in familial hypertelorism: imbalance in ephrin-B1 expression and abnormal phenotypes in humans and mice. Hum Mutat. 2011;32:930-8 pubmed publisher
    ..similarity has been noted to craniofrontonasal syndrome (CFNS), which is caused by mutations in the X-linked EFNB1 gene...
  7. Lin K, Zhao H, Gan S, Li G. Arabidopsis ELF4-like proteins EFL1 and EFL3 influence flowering time. Gene. 2019;700:131-138 pubmed publisher
    ..Overexpression of EFL2, however, failed to rescue this phenotype and overexpression of EFL3 partially rescued the early flowering phenotype...
  8. Aarti C, Khusro A, Varghese R, Arasu M, Agastian P, Al Dhabi N, et al. In vitro investigation on probiotic, anti-Candida, and antibiofilm properties of Lactobacillus pentosus strain LAP1. Arch Oral Biol. 2018;89:99-106 pubmed publisher
    ..0 ± 0.01 log CFU/ml) made the isolate a promising probiotic candidate. Cell-free neutralized supernatant (CFNS) of strain LAP1 exhibited potent antifungal activities against C. albicans, C. tropicalis, and C...
  9. Cejalvo T, Muñoz J, Tobajas E, Alfaro D, García Ceca J, Zapata A. Conditioned deletion of ephrinB1 and/or ephrinB2 in either thymocytes or thymic epithelial cells alters the organization of thymic medulla and favors the appearance of thymic epithelial cysts. Histochem Cell Biol. 2015;143:517-29 pubmed publisher
    ..In the present work, we have used the Cre-LoxP model to selectively delete ephrinB1 and/or ephrinB2 in thymocytes (EfnB1(thy/thy), EfnB2(thy/thy), EfnB1(thy/thy)EfnB2(thy/thy) mice) or TECs (EfnB1(tec/tec), EfnB2(tec/tec), EfnB1(tec/..
  10. Schaner M, Ross D, Ciaravino G, Sorlie T, Troyanskaya O, Diehn M, et al. Gene expression patterns in ovarian carcinomas. Mol Biol Cell. 2003;14:4376-86 pubmed
    ..more highly expressed in the ovarian carcinomas were PAX8 (paired box gene 8), mesothelin, and ephrin-B1 (EFNB1)...
  11. Ridge S, Deokar A, Lee R, Daba K, Macknight R, Weller J, et al. The Chickpea Early Flowering 1 (Efl1) Locus Is an Ortholog of Arabidopsis ELF3. Plant Physiol. 2017;175:802-815 pubmed publisher
    ..In this study, we mapped, sequenced, and characterized Early flowering3 (Efl3), an ortholog of Arabidopsis (Arabidopsis thaliana) EARLY FLOWERING3 (ELF3) that confers ..
  12. Kampen K, Scherpen F, Garcia Manero G, Yang H, Kaspers G, Cloos J, et al. EphB1 Suppression in Acute Myelogenous Leukemia: Regulating the DNA Damage Control System. Mol Cancer Res. 2015;13:982-92 pubmed publisher
    ..The presence of EphB1 allowed EfnB1 ligand-mediated p53 DNA binding, leading to restoration of the DNA damage response (DDR) cascade by the activation ..
  13. Wu T, Zhang B, Raelson J, Yao Y, Wu H, Xu Z, et al. Analysis of the association of EPHB6, EFNB1 and EFNB3 variants with hypertension risks in males with hypogonadism. Sci Rep. 2018;8:14497 pubmed publisher
    ..to human hypertension, we conducted a human genetic study for the association of EPHB6 and its two ligands, EFNB1 and EFNB3, with hypertension in hypogonadic patients...
  14. Kang Y, Wu T, Han X, Gu H, Zhang X. A needle-like reusable surface-enhanced Raman scattering substrate, and its application to the determination of acetamiprid by combining SERS and thin-layer chromatography. Mikrochim Acta. 2018;185:504 pubmed publisher
    ..substrate has been fabricated by electrochemical deposition of dendrite-like gold on carbon fiber needles (Au-CFNs)...
  15. Arthur A, Nguyen T, Paton S, Zannettino A, Gronthos S. Loss of EfnB1 in the osteogenic lineage compromises their capacity to support hematopoietic stem/progenitor cell maintenance. Exp Hematol. 2019;69:43-53 pubmed publisher
    ..The present study examined the influence of EfnB1-expressing osteogenic lineage on HSPC function...
  16. Twigg S, Babbs C, van den Elzen M, Goriely A, Taylor S, McGowan S, et al. Cellular interference in craniofrontonasal syndrome: males mosaic for mutations in the X-linked EFNB1 gene are more severely affected than true hemizygotes. Hum Mol Genet. 2013;22:1654-62 pubmed publisher
    Craniofrontonasal syndrome (CFNS), an X-linked disorder caused by loss-of-function mutations of EFNB1, exhibits a paradoxical sex reversal in phenotypic severity: females characteristically have frontonasal dysplasia, craniosynostosis ..
  17. Perry R, Mallan K, Koo J, Mauch C, Daniels L, Magarey A. Food neophobia and its association with diet quality and weight in children aged 24 months: a cross sectional study. Int J Behav Nutr Phys Act. 2015;12:13 pubmed publisher
    ..Neophobia was measured at 24 months using the Child Food Neophobia Scale (CFNS)...
  18. Li X, Zhang Y, Zheng L, Liu M, Chen C, Jiang H. UTX is an escape from X-inactivation tumor-suppressor in B cell lymphoma. Nat Commun. 2018;9:2720 pubmed publisher
    ..UTX-knockout tumors are more aggressive, showing enhanced brain dissemination and formation of blood vessels. Efnb1 is overexpressed in UTX KO tumors and can lead to such phenotypes...
  19. Sharma A, Wiederin J, Uz M, Ciborowski P, Mallapragada S, Gendelman H, et al. Proteomic analysis of mesenchymal to Schwann cell transdifferentiation. J Proteomics. 2017;165:93-101 pubmed publisher
    ..to, GNAI2, MYL9, ACTN4, ACTN1, ACTB, CAV-1, HSPB1, PHB2, TBB4B, CTGF, TGFI1, ARF6, EZR, GELS, VIM, WNT5A, RTN4, EFNB1. These support axonal guidance, myelination, neural development and neural growth and differentiation...
  20. Delgado Pecellin I, Pérez Ruiz E, Álvarez Ríos A, Delgado Pecellin C, Yahyaoui Macías R, Carrasco Hernández L, et al. Results of the Andalusian Cystic Fibrosis Neonatal Screening Program, 5 Years After Implementation. Arch Bronconeumol. 2018;54:551-558 pubmed publisher
    Cystic fibrosis neonatal screening (CFNS), based on double determination of immunoreactive trypsinogen ([IRT] [IRT1/IRT2]), has been available in Andalusia since May 2011...
  21. Helland S, Bere E, Bjørnarå H, Øverby N. Food neophobia and its association with intake of fish and other selected foods in a Norwegian sample of toddlers: A cross-sectional study. Appetite. 2017;114:110-117 pubmed publisher
    ..5), and frequency of intake of various foods. Food neophobia was rated by the Children's Food Neophobia Scale (CFNS, score range 6-42)...
  22. Taylor H, Khuong A, Wu Z, Xu Q, Morley R, Gregory L, et al. Cell segregation and border sharpening by Eph receptor-ephrin-mediated heterotypic repulsion. J R Soc Interface. 2017;14: pubmed publisher
    ..By suppressing homotypic repulsion, N-cadherin creates a sufficient difference between heterotypic and homotypic repulsion, and enables homotypic cohesion, both of which are required to sharpen borders. ..
  23. Talebian A, Britton R, Ammanuel S, Bepari A, Sprouse F, Birnbaum S, et al. Autonomous and non-autonomous roles for ephrin-B in interneuron migration. Dev Biol. 2017;431:179-193 pubmed publisher
    ..role for ephrin-B reverse signaling in the tangential migration of interneurons into the neocortex using ephrin-B (EfnB1/B2/B3) conditional triple mutant (TMlz) mice and a forebrain inhibitory neuron specific Cre driver...
  24. Agarkar V, Babayeva N, Wilder P, Rizzino A, Tahirov T. Crystal structure of mouse Elf3 C-terminal DNA-binding domain in complex with type II TGF-beta receptor promoter DNA. J Mol Biol. 2010;397:278-89 pubmed publisher
    ..In this study, we determined that Elf3 amino acid residues within this flanking region, including Trp361, are important for the structural integrity of the protein as well as for the Efl3 DNA binding and transactivation activity.
  25. Paumard Hernández B, Berges Soria J, Barroso E, Rivera Pedroza C, Pérez Carrizosa V, Benito Sanz S, et al. Expanding the mutation spectrum in 182 Spanish probands with craniosynostosis: identification and characterization of novel TCF12 variants. Eur J Hum Genet. 2015;23:907-14 pubmed publisher
    ..Spanish craniosynostosis probands, implementing a four-tiered cascade screening of FGFR2, FGFR3, FGFR1, TWIST1 and EFNB1. A total of 43 variants, eight novel, were identified in 113 (62%) patients: 104 (92%) detected in level 1; eight (..
  26. Zhu Y, Tchkonia T, Pirtskhalava T, Gower A, Ding H, Giorgadze N, et al. The Achilles' heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell. 2015;14:644-58 pubmed publisher
    ..Using siRNA to silence expression of key nodes of this network, including ephrins (EFNB1 or 3), PI3Kδ, p21, BCL-xL, or plasminogen-activated inhibitor-2, killed senescent cells, but not proliferating or ..
  27. Nagashima K, Endo A, Ogita H, Kawana A, Yamagishi A, Kitabatake A, et al. Adaptor protein Crk is required for ephrin-B1-induced membrane ruffling and focal complex assembly of human aortic endothelial cells. Mol Biol Cell. 2002;13:4231-42 pubmed
    ..These results indicated that Crk plays a critical role in Rac1-induced membrane ruffling and Rap1-mediated nascent focal complex stabilization contributing to ephrin-B1-induced human aortic endothelial cells migration. ..
  28. Tanaka M, Sasaki K, Kamata R, Sakai R. The C-terminus of ephrin-B1 regulates metalloproteinase secretion and invasion of cancer cells. J Cell Sci. 2007;120:2179-89 pubmed
    ..Our results suggest a novel function of the C-terminus of ephrin-B1 in activating MMP-8 secretion, which promotes the invasion of cancer cells. ..
  29. Zhu L, Dissanayaka W, Green D, Zhang C. Stimulation of EphB2/ephrin-B1 signalling by tumour necrosis factor alpha in human dental pulp stem cells. Cell Prolif. 2015;48:231-8 pubmed publisher
    ..JNK-inhibitor inhibited EphB2 mRNA expression only (P < 0.05). EphB2/ephrin-B1 were invoked in DPSCs with TNF-α treatment via the JNK-dependent pathway, but not NF-ĸB, p38 MAPK or MEK signalling. ..
  30. Rissoan M, Duhen T, Bridon J, Bendriss Vermare N, Peronne C, de Saint Vis B, et al. Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells. Blood. 2002;100:3295-303 pubmed
    ..The identification of genes expressed in PDCs provides new insights into their function and origin. ..
  31. McKinney N, Yuan L, Zhang H, Liu J, Cho Y, Rushing E, et al. EphrinB1 expression is dysregulated and promotes oncogenic signaling in medulloblastoma. J Neurooncol. 2015;121:109-18 pubmed publisher
    ..The remaining family members, except EFNB1, are ubiquitously expressed by over 70-90 % MB, irrespective of subgroup...
  32. Dovey T, Aldridge V, Martin C, Wilken M, Meyer C. Screening Avoidant/Restrictive Food Intake Disorder (ARFID) in children: Outcomes from utilitarian versus specialist psychometrics. Eat Behav. 2016;23:162-167 pubmed publisher
    ..one father completed the Behavioral Pediatrics Feeding Assessment Scale (BPFAS) and the Child Food Neophobia Scale (CFNS)...
  33. Lee E, Le T, Zhu Y, Elakis G, Turner A, Lo W, et al. A craniosynostosis massively parallel sequencing panel study in 309 Australian and New Zealand patients: findings and recommendations. Genet Med. 2018;20:1061-1068 pubmed publisher
    ..Variants were identified most frequently in TCF12 (N = 22) and EFNB1 (N = 8), typically in individuals with nonsyndromic coronal craniosynostosis or TWIST1-negative clinically ..
  34. Zhou R. The Eph family receptors and ligands. Pharmacol Ther. 1998;77:151-81 pubmed
    ..The best known function is their role in the guidance of migration of axons and cells in the nervous system through repulsive interactions. They may also play a role in angiogenesis, tissue patterning, and tumor formation. ..
  35. Sawai Y, Tamura S, Fukui K, Ito N, Imanaka K, Saeki A, et al. Expression of ephrin-B1 in hepatocellular carcinoma: possible involvement in neovascularization. J Hepatol. 2003;39:991-6 pubmed
    ..0001). In addition, in vitro studies revealed that ephrin-B1 induced migration and proliferation of HUVECs. Ephrin-B1 may be involved in in vivo tumor progression by promoting neovascularization in HCC. ..
  36. Chaudhry A, Sabatini P, Han L, Ray P, Forrest C, Bowdin S. Heterozygous mutations in ERF cause syndromic craniosynostosis with multiple suture involvement. Am J Med Genet A. 2015;167A:2544-7 pubmed publisher
    ..The most common single gene causes of syndromic craniosynostosis are mutations in FGFR1, FGFR2, FGFR3, TWIST1, and EFNB1. Recently, a new single gene cause of craniosynostosis was published, together with phenotype data that highlight ..
  37. Kirkegaard K, Villesen P, Jensen J, Hindkjær J, Kølvraa S, Ingerslev H, et al. Distinct differences in global gene expression profiles in non-implanted blastocysts and blastocysts resulting in live birth. Gene. 2015;571:212-20 pubmed publisher
    ..We found that 37 of the 181 genes displayed significantly differential expression (p<0.05), e.g. EFNB1, CYTL1 and TEX26 and TESK1, MSL1 and EVI5 in trophectoderm biopsies associated with live birth and non-implanting, ..
  38. Lee E, Lim K. Formation of chitosan-fucoidan nanoparticles and their electrostatic interactions: Quantitative analysis. J Biosci Bioeng. 2016;121:73-83 pubmed publisher
    ..distributions of both positive amino groups and negative sulfate ions loaded in chitosan-fucoidan nanoparticles (CFNs) were predicted quantitatively by correlating the separate yields of loaded chitosan and fucoidan, and a proposed ..
  39. Tanaka M, Ohashi R, Nakamura R, Shinmura K, Kamo T, Sakai R, et al. Tiam1 mediates neurite outgrowth induced by ephrin-B1 and EphA2. EMBO J. 2004;23:1075-88 pubmed
    ..These results indicate that Tiam1 is required for neurite outgrowth induced by both ephrin-B1-mediated reverse signaling and EphA2-mediated forward signaling. ..
  40. Wilkinson D. Eph receptors and ephrins: regulators of guidance and assembly. Int Rev Cytol. 2000;196:177-244 pubmed
    ..Eph receptors and ephrins have thus emerged as key regulators of the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. ..
  41. Vazin T, Becker K, Chen J, Spivak C, Lupica C, Zhang Y, et al. A novel combination of factors, termed SPIE, which promotes dopaminergic neuron differentiation from human embryonic stem cells. PLoS ONE. 2009;4:e6606 pubmed publisher
    ..were stromal cell-derived factor 1 (SDF-1/CXCL12), pleiotrophin (PTN), insulin-like growth factor 2 (IGF2), and ephrin B1 (EFNB1)...
  42. Lu P, Shih C, Qi H. Ephrin B1-mediated repulsion and signaling control germinal center T cell territoriality and function. Science. 2017;356: pubmed publisher
    ..Here we found that GC-expressed ephrin B1 (EFNB1) repulsively inhibited T cell to B cell adhesion and GC TFH retention by signaling through T<..
  43. Feldman G, Ward D, Lajeunie Renier E, Saavedra D, Robin N, Proud V, et al. A novel phenotypic pattern in X-linked inheritance: craniofrontonasal syndrome maps to Xp22. Hum Mol Genet. 1997;6:1937-41 pubmed
    Craniofrontonasal syndrome (CFNS, OMIM 304110) is a distinctive genetic disorder whose main clinical manifestations include coronal synostosis, widely spaced eyes, clefting of the nasal tip and various skeletal anomalies...
  44. Wallis D, Lacbawan F, Jain M, Der Kaloustian V, Steiner C, Moeschler J, et al. Additional EFNB1 mutations in craniofrontonasal syndrome. Am J Med Genet A. 2008;146A:2008-12 pubmed publisher
  45. Niethamer T, Larson A, O Neill A, Bershteyn M, Hsiao E, Klein O, et al. EPHRIN-B1 Mosaicism Drives Cell Segregation in Craniofrontonasal Syndrome hiPSC-Derived Neuroepithelial Cells. Stem Cell Reports. 2017;8:529-537 pubmed publisher
    ..Craniofrontonasal syndrome (CFNS) is a rare X-linked disorder caused by mutations in EFNB1 and characterized by craniofacial, skeletal, and neurological anomalies...
  46. Yang J, Cai W, Lu X, Liu S, Zhao S. RNA-Sequencing Analyses Demonstrate the Involvement of Canonical Transient Receptor Potential Channels in Rat Tooth Germ Development. Front Physiol. 2017;8:455 pubmed publisher
    ..We found that GNAO1, ENO1, EFNB1, CALM1, SIAH2, ATP6V0A1, KDELR2, GTPBP1, POLR2C, SORT1, and members of the canonical transient receptor ..
  47. Tanaka M, Kamata R, Takigahira M, Yanagihara K, Sakai R. Phosphorylation of ephrin-B1 regulates dissemination of gastric scirrhous carcinoma. Am J Pathol. 2007;171:68-78 pubmed
    ..Our results suggest that tyrosine phosphorylation of ephrin-B1 promotes invasion of cancer cells in vivo and is a potential therapeutic target in some types of gastrointestinal cancers. ..
  48. Nguyen T, Arthur A, Paton S, Hemming S, Panagopoulos R, Codrington J, et al. Loss of ephrinB1 in osteogenic progenitor cells impedes endochondral ossification and compromises bone strength integrity during skeletal development. Bone. 2016;93:12-21 pubmed publisher
    ..ephrinB1 during endochondral ossification using the Cre recombination system with targeted deletion of ephrinB1 (EfnB1fl/fl) in osteogenic progenitor cells, under the control of the osterix (Osx:Cre) promoter...
  49. Varelias A, Koblar S, Cowled P, Carter C, Clayer M. Human osteosarcoma expresses specific ephrin profiles: implications for tumorigenicity and prognosis. Cancer. 2002;95:862-9 pubmed
    ..Ephrin-B1 protein was expressed by osteosarcoma cells and blood vessels. The results of this study suggest that ephrin-B1 expressed by osteosarcoma may be a poor prognostic marker through increased tumorigenicity. ..
  50. Husa A, Magić Å, Larsson M, Fornander T, Pérez Tenorio G. EPH/ephrin profile and EPHB2 expression predicts patient survival in breast cancer. Oncotarget. 2016;7:21362-80 pubmed publisher
    ..EPHA2, EPHA4, EFNB1, EFNB2, EPHB2 and EPHB6 were significantly correlated with the cluster groups and particularly EPHB2 was an ..
  51. Cho H, Hwang Y, Mood K, Ji Y, Lim J, Morrison D, et al. EphrinB1 interacts with CNK1 and promotes cell migration through c-Jun N-terminal kinase (JNK) activation. J Biol Chem. 2014;289:18556-68 pubmed publisher
    ..Moreover, Rho kinase inhibitor or JNK inhibitor treatment suppresses ephrinB1-mediated cell migration. Taken together, our findings suggest that CNK1 is required for ephrinB1-induced JNK activation and cell migration. ..
  52. Owens D, Butler A, Agüero T, Newman K, van Booven D, King M. High-throughput analysis reveals novel maternal germline RNAs crucial for primordial germ cell preservation and proper migration. Development. 2017;144:292-304 pubmed publisher
    ..mRNAs show that sox7 plays a novel and important role in primordial germ cell (PGC) development and that ephrinB1 (efnb1) is required for proper PGC migration...
  53. Davis S, Gale N, Aldrich T, Maisonpierre P, Lhotak V, Pawson T, et al. Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity. Science. 1994;266:816-9 pubmed
    ..Membrane attachment may serve to facilitate ligand dimerization or aggregation, because antibody-mediated clustering activated previously inactive soluble forms of these ligands. ..
  54. Gale N, Holland S, Valenzuela D, Flenniken A, Pan L, Ryan T, et al. Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. Neuron. 1996;17:9-19 pubmed
    ..This reciprocal compartmentalization implicates the Eph family in the formation of spatial boundaries that may help to organize the developing body plan. ..
  55. Kataoka H, Tanaka M, Kanamori M, Yoshii S, Ihara M, Wang Y, et al. Expression profile of EFNB1, EFNB2, two ligands of EPHB2 in human gastric cancer. J Cancer Res Clin Oncol. 2002;128:343-8 pubmed
    ..reported that EPHB2 is overexpressed in gastric cancer; however, the expression profiles of its ligands, EFNB1 and EFNB2, are unknown...
  56. Riedl J, Brandt D, Batlle E, Price L, Clevers H, Bos J. Down-regulation of Rap1 activity is involved in ephrinB1-induced cell contraction. Biochem J. 2005;389:465-9 pubmed
    ..From these results, we conclude that down-regulation of Rap1 is a prerequisite for ephrin-induced cell retraction in colon cells. ..
  57. Stokowski A, Shi S, Sun T, Bartold P, Koblar S, Gronthos S. EphB/ephrin-B interaction mediates adult stem cell attachment, spreading, and migration: implications for dental tissue repair. Stem Cells. 2007;25:156-64 pubmed
    ..These results may have implications for dental pulp development and regeneration. ..
  58. Özylmaz B, Gezdirici A, Özen M, Kalenderer Ã. Report of a family with craniofrontonasal syndrome. Clin Dysmorphol. 2015;24:79-83 pubmed publisher
    ..Here, we report a family with a G151S mutation in the EFNB1 gene...
  59. Wilkie A, Byren J, Hurst J, Jayamohan J, Johnson D, Knight S, et al. Prevalence and complications of single-gene and chromosomal disorders in craniosynostosis. Pediatrics. 2010;126:e391-400 pubmed publisher
  60. Torres R, Firestein B, Dong H, Staudinger J, Olson E, Huganir R, et al. PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands. Neuron. 1998;21:1453-63 pubmed
    ..Thus, PDZ proteins may play critical roles in localizing vertebrate receptor tyrosine kinases and/or their ligands and may be particularly important for Eph function in guidance or patterning or at the synapse. ..
  61. Becker E, Huynh Do U, Holland S, Pawson T, Daniel T, Skolnik E. Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation. Mol Cell Biol. 2000;20:1537-45 pubmed
    ..Taken together, these findings support a model in which the recruitment of the Ste20 kinase NIK to phosphotyrosine-containing proteins by Nck is an important proximal step in the signaling cascade downstream of EphRs. ..
  62. Prevost N, Woulfe D, Tognolini M, Tanaka T, Jian W, Fortna R, et al. Signaling by ephrinB1 and Eph kinases in platelets promotes Rap1 activation, platelet adhesion, and aggregation via effector pathways that do not require phosphorylation of ephrinB1. Blood. 2004;103:1348-55 pubmed
  63. Hogue J, Shankar S, Perry H, Patel R, Vargervik K, Slavotinek A. A novel EFNB1 mutation (c.712delG) in a family with craniofrontonasal syndrome and diaphragmatic hernia. Am J Med Genet A. 2010;152A:2574-7 pubmed publisher
    ..diaphragmatic hernia in a family with craniofrontonasal syndrome found to have a previously unreported mutation in EFNB1. The female proband presented with hypertelorism, telecanthus, bifid nasal tip, widow's peak, frontal bossing, and ..
  64. Yoo H, Ko J, Lim B, Cheong H. First Korean Patients with Craniofrontonasal Syndrome Confirmed by EFNB1 Analysis. Ann Clin Lab Sci. 2016;46:544-8 pubmed
    ..A Sanger sequencing analysis of these patients revealed one novel (IVS2+3G>T) and one previously reported mutation (p.Gly151Ser) in EFNB1 Both patients were de novo cases without a family history of CFNS.
  65. Han D, Shen T, Miao H, Wang B, Guan J. EphB1 associates with Grb7 and regulates cell migration. J Biol Chem. 2002;277:45655-61 pubmed
    ..Together, our results identified a novel interaction between EphB1 with the adaptor molecule Grb7 and suggested that this interaction may play a role in the regulation of cell migration by EphB1. ..
  66. Hwang Y, Lee H, Kamata T, Mood K, Cho H, Winterbottom E, et al. The Smurf ubiquitin ligases regulate tissue separation via antagonistic interactions with ephrinB1. Genes Dev. 2013;27:491-503 pubmed publisher
    ..This system of differential interactions between Smurfs and ephrinB1 regulates the maintenance of tissue boundaries through the control of ephrinB protein levels. ..
  67. van den Elzen M, Twigg S, Goos J, Hoogeboom A, van den Ouweland A, Wilkie A, et al. Phenotypes of craniofrontonasal syndrome in patients with a pathogenic mutation in EFNB1. Eur J Hum Genet. 2014;22:995-1001 pubmed publisher
    Craniofrontonasal syndrome (CFNS) is an X-linked developmental malformation, caused by mutations in the EFNB1 gene, which have only been described since 2004. A genotype-phenotype correlation seems not to be present...
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    ..We injected the gamma-aminobutyric acid A agonist muscimol into one or both CFNs where we had recorded pursuit-related neurons a few minutes earlier...
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    ..Our findings suggest that GRIP proteins provide a scaffold for the assembly of a multiprotein signaling complex downstream of ephrinB ligands. ..
  72. Jiang G, Freywald T, Webster J, Kozan D, Geyer R, Decoteau J, et al. In human leukemia cells ephrin-B-induced invasive activity is supported by Lck and is associated with reassembling of lipid raft signaling complexes. Mol Cancer Res. 2008;6:291-305 pubmed publisher
  73. Hoffmann M, Thieme H, Liedecke K, Meltendorf S, Zenker M, Wieland I. Visual Pathways in Humans With Ephrin-B1 Deficiency Associated With the Cranio-Fronto-Nasal Syndrome. Invest Ophthalmol Vis Sci. 2015;56:7427-37 pubmed publisher
    ..system in humans with ephrin-B1 deficiency, which is x-linked and associated with the cranio-fronto-nasal syndrome (CFNS) in heterozygous females...
  74. Fletcher F, Huebner K, Shaffer L, Fairweather N, Monaco A, Muller U, et al. Assignment of the gene (EPLG2) encoding a high-affinity binding protein for the receptor tyrosine kinase elk to a 200-kilobasepair region in human chromosome Xq12. Genomics. 1995;25:334-5 pubmed
  75. Lackmann M, Mann R, Kravets L, Smith F, Bucci T, Maxwell K, et al. Ligand for EPH-related kinase (LERK) 7 is the preferred high affinity ligand for the HEK receptor. J Biol Chem. 1997;272:16521-30 pubmed
    ..By extrapolation, our findings indicate that some of the reported LERK-receptor interactions are a consequence of the use of bivalent ligand or receptor constructs and may be functionally irrelevant. ..
  76. Lin D, Gish G, Songyang Z, Pawson T. The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif. J Biol Chem. 1999;274:3726-33 pubmed
    ..In vitro studies demonstrated that the fifth PDZ domain of FAP-1 and full-length syntenin bound ephrin B1 via the carboxyl-terminal motif...
  77. Böhme B, Vandenbos T, Cerretti D, Park L, Holtrich U, Rübsamen Waigmann H, et al. Cell-cell adhesion mediated by binding of membrane-anchored ligand LERK-2 to the EPH-related receptor human embryonal kinase 2 promotes tyrosine kinase activity. J Biol Chem. 1996;271:24747-52 pubmed
    ..Coexpression of HEK2 and LERK-2 in 32D cells showed reduced kinase activity and autophosphorylation of HEK2 compared with the juxtacrine stimulation, which seems to be due to a reduced sensitivity of the receptor. ..
  78. Xu Q, Mellitzer G, Wilkinson D. Roles of Eph receptors and ephrins in segmental patterning. Philos Trans R Soc Lond B Biol Sci. 2000;355:993-1002 pubmed
    ..Eph receptors and ephrins have thus emerged as key regulators that, in parallel with cell adhesion molecules, underlie the establishment and maintenance of patterns of cellular organization. ..
  79. Kalo M, Yu H, Pasquale E. In vivo tyrosine phosphorylation sites of activated ephrin-B1 and ephB2 from neural tissue. J Biol Chem. 2001;276:38940-8 pubmed
    ..1999) Biochemistry 38, 14396-14408) are also phosphorylated in retinal tissue. Our data underline the complexity of ephrin-Eph bidirectional signaling by implicating many tyrosine phosphorylation sites of the ligand-receptor complex. ..
  80. Cortina C, Palomo Ponce S, Iglesias M, Fernández Masip J, Vivancos A, Whissell G, et al. EphB-ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells. Nat Genet. 2007;39:1376-83 pubmed
    ..Our results indicate that CRC cells must silence EphB expression to avoid repulsive interactions imposed by normal ephrin-B1-expressing intestinal cells at the onset of tumorigenesis. ..
  81. Yin H, Lu C, Tang Y, Wang H, Wang H, Wang J. Enhanced expression of EphrinB1 is associated with lymph node metastasis and poor prognosis in breast cancer. Cancer Biomark. 2013;13:261-7 pubmed publisher
    ..015). Our analysis demonstrates that EphrinB1 expression is related to the metastasis of breast cancer and its enhanced expression confers a poor prognosis, suggesting that EphrinB1 may be a relevant therapeutic target in breast cancers. ..
  82. Parker M, Roberts R, Enriquez M, Zhao X, Takahashi T, Pat Cerretti D, et al. Reverse endocytosis of transmembrane ephrin-B ligands via a clathrin-mediated pathway. Biochem Biophys Res Commun. 2004;323:17-23 pubmed
    ..These results suggest that ephrin-B1 internalization is an active receptor-mediated process that utilizes the clathrin-mediated endocytic pathway. ..
  83. Hu Y, Wang X, Wu Y, Jin W, Cheng B, Fang X, et al. Role of EFNB1 and EFNB2 in Mouse Collagen-Induced Arthritis and Human Rheumatoid Arthritis. Arthritis Rheumatol. 2015;67:1778-88 pubmed publisher
    b>EFNB1 and EFNB2 are ligands for Eph receptor tyrosine kinases...
  84. Prevost N, Woulfe D, Tanaka T, Brass L. Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred. Proc Natl Acad Sci U S A. 2002;99:9219-24 pubmed
  85. Liu C, Cheng J, Li T, Tan P. Integrated analysis of microRNA and mRNA expression profiles in the rat spinal cord under inflammatory pain conditions. Eur J Neurosci. 2017;: pubmed publisher
    ..changes were noted in miR-124, miR-29, miR-34, miR-30, miR-338 and their target genes, TIMP2, CREB5 and EFNB1. We also investigated an interaction pair, miR-124-3p and IL-6R, and the results showed that miR-124-3p could ..
  86. Flanagan J, Vanderhaeghen P. The ephrins and Eph receptors in neural development. Annu Rev Neurosci. 1998;21:309-45 pubmed
    ..This large family of ligands and receptors may make a major contribution to the accurate spatial patterning of connections and cell position in the nervous system. ..
  87. Colbert P, Vermeer D, Wieking B, Lee J, Vermeer P. EphrinB1: novel microtubule associated protein whose expression affects taxane sensitivity. Oncotarget. 2015;6:953-68 pubmed
    ..Thus, HPV infection or functional mutations of PTPN13 in non-viral cancers may predict taxane sensitivity. ..
  88. Li J, Sun Z, Yuan Y, Yin F, Bian Y, Long L, et al. EphB3 Stimulates Cell Migration and Metastasis in a Kinase-dependent Manner through Vav2-Rho GTPase Axis in Papillary Thyroid Cancer. J Biol Chem. 2017;292:1112-1121 pubmed publisher
    ..Either overexpression of EphB3 or activation of EphB3 by EfnB1-Fc/EfnB2-Fc stimulated in vitro migration of PTC cells...
  89. Cerretti D, Lyman S, Kozlosky C, Copeland N, Gilbert D, Jenkins N, et al. The genes encoding the eph-related receptor tyrosine kinase ligands LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4, Epl4) are clustered on human chromosome 1 and mouse chromosome 3. Genomics. 1996;33:277-82 pubmed
    ..For example, LERK-2 (EPLG2, Epl2) and LERK-5 (EPLG5, Epl5) are type 1 transmembrane proteins, while LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3)..
  90. Kitamura T, Kabuyama Y, Kamataki A, Homma M, Kobayashi H, Aota S, et al. Enhancement of lymphocyte migration and cytokine production by ephrinB1 system in rheumatoid arthritis. Am J Physiol Cell Physiol. 2008;294:C189-96 pubmed
    ..Inhibition of the ephrinB/EphB system might be a novel target for the treatment of RA. ..
  91. Tanaka M, Kuriyama S, Aiba N. Nm23-H1 regulates contact inhibition of locomotion, which is affected by ephrin-B1. J Cell Sci. 2012;125:4343-53 pubmed publisher
    ..As one mechanism, ephrin-B1 inhibits the association of Nm23-H1 with Tiam1, which contributes for activation of Rac1. These results indicate a novel function of Nm23-H1 to control CIL, and its negative regulation by ephrin-B1. ..