Gene Symbol: EEF1A2
Description: eukaryotic translation elongation factor 1 alpha 2
Alias: EEF1AL, EF-1-alpha-2, EF1A, EIEE33, HS1, MRD38, STN, STNL, elongation factor 1-alpha 2, eukaryotic elongation factor 1 A-2, statin-S1
Species: human
Products:     EEF1A2

Top Publications

  1. Grassi G, Scaggiante B, Farra R, Dapas B, Agostini F, Baiz D, et al. The expression levels of the translational factors eEF1A 1/2 correlate with cell growth but not apoptosis in hepatocellular carcinoma cell lines with different differentiation grade. Biochimie. 2007;89:1544-52 pubmed
    Despite the involvement of the elongation factors eEF1A (eEF1A1 and eEF1A2) in the development of different cancers no information is available on their possible contribution to the biology of hepatocellular carcinoma (HCC)...
  2. Lund A, Knudsen S, Vissing H, Clark B, Tommerup N. Assignment of human elongation factor 1alpha genes: EEF1A maps to chromosome 6q14 and EEF1A2 to 20q13.3. Genomics. 1996;36:359-61 pubmed
    The human elongation factor 1alpha gene family consists of at least 2 actively transcribed genes, EEF1A and EEF1A2, and more than 18 homologous loci...
  3. Jeganathan S, Morrow A, Amiri A, Lee J. Eukaryotic elongation factor 1A2 cooperates with phosphatidylinositol-4 kinase III beta to stimulate production of filopodia through increased phosphatidylinositol-4,5 bisphosphate generation. Mol Cell Biol. 2008;28:4549-61 pubmed publisher
    Eukaryotic elongation factor 1 alpha 2 (eEF1A2) is a transforming gene product that is highly expressed in human tumors of the ovary, lung, and breast...
  4. Cao H, Zhu Q, Huang J, Li B, Zhang S, Yao W, et al. Regulation and functional role of eEF1A2 in pancreatic carcinoma. Biochem Biophys Res Commun. 2009;380:11-6 pubmed publisher
    ..In this study, we found that eEF1A2, a gene located in 20q13, was significantly upregulated in pancreatic cancer...
  5. Tomlinson V, Newbery H, Wray N, Jackson J, Larionov A, Miller W, et al. Translation elongation factor eEF1A2 is a potential oncoprotein that is overexpressed in two-thirds of breast tumours. BMC Cancer. 2005;5:113 pubmed
    The tissue-specific translation elongation factor eEF1A2 was recently shown to be a potential oncogene that is overexpressed in ovarian cancer...
  6. Pinke D, Lee J. The lipid kinase PI4KIII? and the eEF1A2 oncogene co-operate to disrupt three-dimensional in vitro acinar morphogenesis. Exp Cell Res. 2011;317:2503-11 pubmed publisher
    ..Furthermore, expression of an oncogenic PI4KIII? activator, eEF1A2 (eukaryotic elongation factor 1 alpha 2), phenocopies the PI4KIII? multi-acinar phenotype...
  7. Scaggiante B, Dapas B, Bonin S, Grassi M, Zennaro C, Farra R, et al. Dissecting the expression of EEF1A1/2 genes in human prostate cancer cells: the potential of EEF1A2 as a hallmark for prostate transformation and progression. Br J Cancer. 2012;106:166-73 pubmed publisher
    ..On the contrary, a significant rise of EEF1A2 mRNA and protein were found, with the highest levels detected in LNCaP...
  8. Anand N, Murthy S, Amann G, Wernick M, Porter L, Cukier I, et al. Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer. Nat Genet. 2002;31:301-5 pubmed
    We have found that EEF1A2, the gene encoding protein elongation factor EEF1A2 (also known as eEF-1 alpha 2), is amplified in 25% of primary ovarian tumors and is highly expressed in approximately 30% of ovarian tumors and established cell ..
  9. Lee M, Surh Y. eEF1A2 as a putative oncogene. Ann N Y Acad Sci. 2009;1171:87-93 pubmed publisher
    The first evidence for the role of the protein elongation factor eEF1A2 in tumorigenesis was reported by Anand and colleagues who demonstrated that eEF1A2 is overexpressed in about 30% of ovarian tumors and some established ovarian cancer ..

More Information

Publications118 found, 100 shown here

  1. Soares D, Barlow P, Newbery H, Porteous D, Abbott C. Structural models of human eEF1A1 and eEF1A2 reveal two distinct surface clusters of sequence variation and potential differences in phosphorylation. PLoS ONE. 2009;4:e6315 pubmed publisher
    ..identity, paralogous human translation elongation factor 1 alpha-1 (eEF1A1) and elongation factor 1 alpha-2 (eEF1A2) have different but overlapping functional profiles...
  2. Tomlinson V, Newbery H, Bergmann J, Boyd J, Scott D, Wray N, et al. Expression of eEF1A2 is associated with clear cell histology in ovarian carcinomas: overexpression of the gene is not dependent on modifications at the EEF1A2 locus. Br J Cancer. 2007;96:1613-20 pubmed
    The tissue-specific translation elongation factor eEF1A2 is a potential oncogene that is overexpressed in human ovarian cancer...
  3. Knudsen S, Frydenberg J, Clark B, Leffers H. Tissue-dependent variation in the expression of elongation factor-1 alpha isoforms: isolation and characterisation of a cDNA encoding a novel variant of human elongation-factor 1 alpha. Eur J Biochem. 1993;215:549-54 pubmed
    ..EF-1 alpha was expressed in brain, placenta, lung, liver, kidney, pancreas and in all the cell lines that we have analysed but barely detectable in heart and skeletal muscle. ..
  4. Jeganathan S, Lee J. Binding of elongation factor eEF1A2 to phosphatidylinositol 4-kinase beta stimulates lipid kinase activity and phosphatidylinositol 4-phosphate generation. J Biol Chem. 2007;282:372-80 pubmed
    Eukaryotic protein translation elongation factor 1 alpha 2 (eEF1A2) is an oncogene that transforms mammalian cell lines and increases their tumorigenicity in nude mice...
  5. Amiri A, Noei F, Jeganathan S, Kulkarni G, Pinke D, Lee J. eEF1A2 activates Akt and stimulates Akt-dependent actin remodeling, invasion and migration. Oncogene. 2007;26:3027-40 pubmed
    eEF1A2 (eukaryotic protein elongation factor 1 alpha 2) is a protein translation factor that is likely a human oncogene by virtue of its capacity to transform mammalian cells and its high expression in tumors of the ovary, breast and ..
  6. Li Z, Qi C, Shin D, Zingone A, Newbery H, Kovalchuk A, et al. Eef1a2 promotes cell growth, inhibits apoptosis and activates JAK/STAT and AKT signaling in mouse plasmacytomas. PLoS ONE. 2010;5:e10755 pubmed publisher
    The canonical function of EEF1A2, normally expressed only in muscle, brain, and heart, is in translational elongation, but recent studies suggest a non-canonical function as a proto-oncogene that is overexpressed in a variety of solid ..
  7. Xu C, Hu D, Zhu Q. eEF1A2 promotes cell migration, invasion and metastasis in pancreatic cancer by upregulating MMP-9 expression through Akt activation. Clin Exp Metastasis. 2013;30:933-44 pubmed publisher
    b>eEF1A2 is a protein translation factor involved in protein synthesis that is overexpressed in various cancers, with important functions in tumor genesis and progression...
  8. Li R, Wang H, Bekele B, Yin Z, Caraway N, Katz R, et al. Identification of putative oncogenes in lung adenocarcinoma by a comprehensive functional genomic approach. Oncogene. 2006;25:2628-35 pubmed
    ..Comparing the 183 genes with the 42 proteins, we identified four genes - PRDX1, EEF1A2, CALR, and KCIP-1 - in which elevated protein expression correlated with both increased DNA copy number and ..
  9. Oertel W, Schulz J. Current and experimental treatments of Parkinson disease: A guide for neuroscientists. J Neurochem. 2016;139 Suppl 1:325-337 pubmed publisher
    ..Alternatively, the patient is offered deep brain stimulation of the subthalamic nucleus (STN) or the internal part of the globus pallidus (GPi)...
  10. Shekh K, Tang S, Niyogi S, Hecker M. Expression stability and selection of optimal reference genes for gene expression normalization in early life stage rainbow trout exposed to cadmium and copper. Aquat Toxicol. 2017;190:217-227 pubmed publisher
    ..genes were: beta actin (b-actin), DNA directed RNA polymerase II subunit I (DRP2), elongation factor-1 alpha (EF1a), glyceraldehyde 3-phosphate dehydrogenase (GAPDH), glucose-6-phosphate dehydrogenase (G6PD), hypoxanthine ..
  11. Lu Y, Yuan M, Gao X, Kang T, Zhan S, Wan H, et al. Identification and validation of reference genes for gene expression analysis using quantitative PCR in Spodoptera litura (Lepidoptera: Noctuidae). PLoS ONE. 2013;8:e68059 pubmed publisher
    ..We believe that these results make an important contribution to gene analysis studies in S. litura and form the basis of further research on stable reference genes in S. litura and other organisms. ..
  12. Tucker H, Mahoney E, Chhetri A, Unger K, Mamone G, Kim G, et al. Deep brain stimulation of the ventroanterior and ventrolateral thalamus improves motor function in a rat model of Parkinson's disease. Exp Neurol. 2019;317:155-167 pubmed publisher
    ..the two FDA-approved brain targets for PD situated in the basal ganglia; specifically, in the subthalamic nucleus (STN) and globus pallidus pars interna (GPi)...
  13. Zhao Q, He Y, Wang X, Zhang Y, Wu Y. Differentially expressed proteins among normal cervix, cervical intraepithelial neoplasia and cervical squamous cell carcinoma. Clin Transl Oncol. 2015;17:620-31 pubmed publisher
    ..S100A9, eEF1A1 and PKM2 may become candidate markers for early diagnosis of cervical cancer and new targets for therapy. It also provides a basis for further studies of the mechanism for CIN developing to CSCC. ..
  14. Silva M, Knowles D, Suarez C. Identification of interchangeable cross-species function of elongation factor-1 alpha promoters in Babesia bigemina and Babesia bovis. Parasit Vectors. 2016;9:576 pubmed
    ..bigemina and B. bovis which is described for the first time in Babesia species. This study is of significance for development of interspecies stable transfection systems for B. bigemina and for B. bovis. ..
  15. Jones B, Penkert R, Xu B, Fan Y, Neale G, Gearhart P, et al. Binding of estrogen receptors to switch sites and regulatory elements in the immunoglobulin heavy chain locus of activated B cells suggests a direct influence of estrogen on antibody expression. Mol Immunol. 2016;77:97-102 pubmed publisher
    ..Additional peaks of ER? binding were coincident with hs1,2 and hs4 sites in the 3' regulatory region (3'RR) of the heavy chain locus...
  16. Omoshaba E, Olufemi F, Ojo O, Sonibare A, Agbaje M. Multidrug-resistant Salmonellae isolated in Japanese quails reared in Abeokuta, Nigeria. Trop Anim Health Prod. 2017;49:1455-1460 pubmed publisher
    ..chain reaction assays for the amplification and detection of Salmonella-associated virulence genes (invA and stn) using specific primers. Antimicrobial susceptibility testing was done using the Kirby-Bauer disk diffusion method...
  17. V Patankar H, M Assaha D, Al Yahyai R, Sunkar R, Yaish M. Identification of Reference Genes for Quantitative Real-Time PCR in Date Palm (Phoenix dactylifera L.) Subjected to Drought and Salinity. PLoS ONE. 2016;11:e0166216 pubmed publisher
  18. Lou Q, Cao S, Xu W, Zhang Y, Qin Z, Wei W. Molecular characterization and mRNA expression of ribosomal protein L8 in Rana nigromaculata during development and under exposure to hormones. J Environ Sci (China). 2014;26:2331-9 pubmed publisher
    ..nigromaculata, and might also provide support for using rpl8 as a reference gene in other Rana species due to the high conservation of rpl8 among the Rana genus. ..
  19. Alves L, Oliveira C, Goldenberg S. Eukaryotic translation elongation factor-1 alpha is associated with a specific subset of mRNAs in Trypanosoma cruzi. BMC Microbiol. 2015;15:104 pubmed publisher
    ..We observed the enrichment of functionally related transcripts bound to EF-1α in normal growth conditions as well as in nutritionally stressed cell indicating a potential role of EF-1α mRNP in stress response. ..
  20. Mishra V, Passari A, Chandra P, Leo V, Kumar B, Uthandi S, et al. Determination and production of antimicrobial compounds by Aspergillus clavatonanicus strain MJ31, an endophytic fungus from Mirabilis jalapa L. using UPLC-ESI-MS/MS and TD-GC-MS analysis. PLoS ONE. 2017;12:e0186234 pubmed publisher
  21. Muratoglu H, Nalcacioglu R, Arif B, Demirbag Z. Genome-wide analysis of differential mRNA expression of Amsacta moorei entomopoxvirus, mediated by the gene encoding a viral protein kinase (AMV197). Virus Res. 2016;215:25-36 pubmed publisher
    ..cellular genes including metabolism of apoptosis (Nedd2-like caspase, hemolin and elongation factor-1 alpha (ef1a) gene) was downregulated in the absence of amv197...
  22. Inan S, Soner B, Sahin A. Behavioural effects of basal ganglia rho-kinase inhibition in the unilateral 6-hydroxydopamine rat model of Parkinson's disease. Metab Brain Dis. 2016;31:849-57 pubmed publisher
    ..In this later stage, high frequency deep brain stimulation of the subthalamic nucleus (STN-DBS) is a treatment option which is most successful to treat drug resistant advanced PD...
  23. Hakimi H, Yamagishi J, Kegawa Y, Kaneko O, Kawazu S, Asada M. Establishment of transient and stable transfection systems for Babesia ovata. Parasit Vectors. 2016;9:171 pubmed publisher
    ..These results confirm successful development of a stable transfection system for B. ovata. The current study provides a fundamental molecular tool to aid in molecular and cellular studies of B. ovata. ..
  24. Rojo Bustamante E, Abellanas M, Clavero P, Thiolat M, Li Q, Luquin M, et al. The expression of cannabinoid type 1 receptor and 2-arachidonoyl glycerol synthesizing/degrading enzymes is altered in basal ganglia during the active phase of levodopa-induced dyskinesia. Neurobiol Dis. 2018;118:64-75 pubmed publisher
    ..external segment of the globus pallidus (GPe), internal segment of the globus pallidus (GPi), subthalamic nucleus (STN) and substantia nigra (SN) were dissected out from cryostat sections obtained from two groups of parkinsonian ..
  25. Veith N, Ziehr H, MacLeod R, Reamon Buettner S. Mechanisms underlying epigenetic and transcriptional heterogeneity in Chinese hamster ovary (CHO) cell lines. BMC Biotechnol. 2016;16:6 pubmed publisher
    ..Our results suggest that the chromatin state along the EEF1A1 promoter region can help predict recombinant mRNA expression, and thus may assist in selecting desirable clones during cell line development for protein production. ..
  26. Nassery A, Palmese C, Sarva H, Groves M, Miravite J, Kopell B. Psychiatric and Cognitive Effects of Deep Brain Stimulation for Parkinson's Disease. Curr Neurol Neurosci Rep. 2016;16:87 pubmed publisher
    ..While motor benefits are well documented, cognitive and psychiatric side effects from the subthalamic nucleus (STN) and globus pallidus interna (GPi) DBS for PD are increasingly recognized...
  27. Xia X, Huo W, Wan R, Xia X, Du Q, Chang Z. Identification of housekeeping genes as references for quantitative real-time RT-PCR analysis in Misgurnus anguillicaudatus. J Genet. 2017;96:895-904 pubmed
    ..This study could provide useful guidelines that can be expected to aid M. anguillicaudatus researchers in their initial choice of housekeeping genes for future studies and enable more accurate normalization of gene expression data. ..
  28. Schulte L, Sprenger C, May A. Physiological brainstem mechanisms of trigeminal nociception: An fMRI study at 3T. Neuroimage. 2016;124:518-525 pubmed publisher
    ..observed in areas typically involved in trigeminal nociceptive processing such as the spinal trigeminal nuclei (sTN), thalamus, secondary somatosensory cortex, insular cortex and cerebellum as well as in a pain modulating network ..
  29. Lizarraga K, Jagid J, Luca C. Comparative effects of unilateral and bilateral subthalamic nucleus deep brain stimulation on gait kinematics in Parkinson's disease: a randomized, blinded study. J Neurol. 2016;263:1652-6 pubmed publisher Parkinson's disease (PD) does not always respond to bilateral subthalamic nucleus deep brain stimulation (STN-DBS)...
  30. Šišić A, Al Hatmi A, Baćanović Šišić J, Ahmed S, Dennenmoser D, de Hoog G, et al. Two new species of the Fusarium solani species complex isolated from compost and hibiscus (Hibiscus sp.). Antonie Van Leeuwenhoek. 2018;111:1785-1805 pubmed publisher
    ..stercicola and F. witzenhausenense are not host-specific and are ecologically fit to sustain stable populations in variety of habitats. ..
  31. Jakobsson M, Malecki J, Nilges B, Moen A, Leidel S, Falnes P. Methylation of human eukaryotic elongation factor alpha (eEF1A) by a member of a novel protein lysine methyltransferase family modulates mRNA translation. Nucleic Acids Res. 2017;45:8239-8254 pubmed publisher
    ..Finally, we show that eEF1A-KMT4 is part of a novel family of human KMTs, defined by a shared sequence motif in the active site and we demonstrate the importance of this motif for catalytic activity. ..
  32. Migliaccio N, Ruggiero I, Martucci N, Sanges C, Arbucci S, Tatè R, et al. New insights on the interaction between the isoforms 1 and 2 of human translation elongation factor 1A. Biochimie. 2015;118:1-7 pubmed publisher
    ..To this end, we developed chimera proteins by adding at the N-terminal end of both eEF1A1 and eEF1A2 cyan fluorescence protein (mCerulean) and yellow fluorescence protein (mVenus), respectively...
  33. Lezcano E, Gómez Esteban J, Tijero B, Bilbao G, Lambarri I, Rodríguez O, et al. Long-term impact on quality of life of subthalamic nucleus stimulation in Parkinson's disease. J Neurol. 2016;263:895-905 pubmed publisher
    Long-term impact of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on health-related quality of life (HRQOL) and associated factors in patients with Parkinson's disease (PD) are not clear...
  34. Hacobian A, Posa Markaryan K, Sperger S, Stainer M, Hercher D, Feichtinger G, et al. Improved osteogenic vector for non-viral gene therapy. Eur Cell Mater. 2016;31:191-204 pubmed
    ..Taken together, by enhancing the exogenous BMP-2 expression system, low transfection efficiencies in therapeutic applications can be compensated, making safe non-viral systems even more suitable for tissue regeneration approaches. ..
  35. Choi B, Shen G, Nan G, Kim J, Jung K, Jeon B. Dramatic psychiatric and behavioral symptoms following a subthalamic lesion. J Clin Neurosci. 2018;47:154-156 pubmed publisher
    Neuropsychiatric symptoms have been well documented after subthalamic nucleus deep brain stimulation (STN-DBS), but those following a subthalamic lesion have been rarely reported...
  36. Arlotti M, Marceglia S, Foffani G, Volkmann J, Lozano A, Moro E, et al. Eight-hours adaptive deep brain stimulation in patients with Parkinson disease. Neurology. 2018;90:e971-e976 pubmed publisher
    ..046), and this automatic adjustment of STN-DBS prevented dyskinesias...
  37. Salah H, Al Hatmi A, Theelen B, Abukamar M, Hashim S, Van Diepeningen A, et al. Phylogenetic diversity of human pathogenic Fusarium and emergence of uncommon virulent species. J Infect. 2015;71:658-66 pubmed publisher
    ..Less frequently encountered were the FOSC, FFSC and FDSC. More accurate molecular identification of Fusarium species is important to predict therapeutic outcome and the emergence of these species. ..
  38. Combs H, Folley B, Berry D, Segerstrom S, Han D, Anderson Mooney A, et al. Cognition and Depression Following Deep Brain Stimulation of the Subthalamic Nucleus and Globus Pallidus Pars Internus in Parkinson's Disease: A Meta-Analysis. Neuropsychol Rev. 2015;25:439-54 pubmed publisher
    ..Deep brain stimulation (DBS) of the subthalamic nucleus (STN) or globus pallidus internus (GPi) is FDA approved and has been shown to be effective in reducing motor symptoms of ..
  39. Wang Z, Chen H, Ma H, Ma L, Wu T, Feng T. Resting-state functional connectivity of subthalamic nucleus in different Parkinson's disease phenotypes. J Neurol Sci. 2016;371:137-147 pubmed publisher
    Previous studies showed that the subthalamic nucleus (STN) plays a crucial role in Parkinson's disease (PD) pathophysiology. During rest, PD phenotypes exhibit different STN functional connectivity...
  40. Karlsson F, Malinova E, Olofsson K, Blomstedt P, Linder J, Nordh E. Voice Tremor Outcomes of Subthalamic Nucleus and Zona Incerta Deep Brain Stimulation in Patients With Parkinson Disease. J Voice. 2018;: pubmed publisher
    We aimed to study the effect of deep brain stimulation (DBS) in the subthalamic nucleus (STN) and caudal zona incerta (cZi) on level of perceived voice tremor in patients with Parkinson disease (PD)...
  41. Shehab S, D souza C, Ljubisavljevic M, Redgrave P. Activation of the subthalamic nucleus suppressed by high frequency stimulation: A c-Fos immunohistochemical study. Brain Res. 2018;1685:42-50 pubmed publisher
    Deep brain stimulation applied at high frequency (HFS) to the subthalamic nucleus (STN) is used to ameliorate the symptoms of Parkinson's disease. The mechanism by which this is achieved remains controversial...
  42. Longerich T. [EEF1A2 inhibits the p53 function in hepatocellular carcinoma via PI3K/AKT/mTOR-dependent stabilization of MDM4]. Pathologe. 2014;35 Suppl 2:177-84 pubmed publisher
    ..Upregulation of PI3K/AKT/mTOR signaling may result from overexpression of the eukaryotic elongation factor 1A2 (EEF1A2)...
  43. Ramírez Zamora A, Smith H, Youn Y, Durphy J, Shin D, Pilitsis J. Hyperhidrosis associated with subthalamic deep brain stimulation in Parkinson's disease: Insights into central autonomic functional anatomy. J Neurol Sci. 2016;366:59-64 pubmed publisher
    ..We present two patients managed with subthalamic nucleus (STN) Deep Brain Stimulation (DBS) for motor fluctuations in PD that developed reproducible hyperhidrosis with high ..
  44. Cif L, Coubes P. Historical developments in children's deep brain stimulation. Eur J Paediatr Neurol. 2017;21:109-117 pubmed publisher
    ..Concurrent targets such as subthalamic nucleus (STN) and several motor nuclei of the thalamus are under exploration and only little information is available in ..
  45. Janssen M, Temel Y, Delaville C, Zwartjes D, Heida T, De Deurwaerdère P, et al. Cortico-subthalamic inputs from the motor, limbic, and associative areas in normal and dopamine-depleted rats are not fully segregated. Brain Struct Funct. 2017;222:2473-2485 pubmed publisher
    The subthalamic nucleus (STN) receives monosynaptic glutamatergic afferents from different areas of the cortex, known as the "hyperdirect" pathway...
  46. Rouhollahi K, Emadi Andani M, Karbassi S, Izadi I. Design of robust adaptive controller and feedback error learning for rehabilitation in Parkinson's disease: a simulation study. IET Syst Biol. 2017;11:19-29 pubmed publisher
    ..One area (STN: subthalamic nucleus) is stimulated by an adaptive controller with feedback error learning...
  47. Beck A, Lütjens G, Schwabe K, Dengler R, Krauss J, Sandmann P. Thalamic and basal ganglia regions are involved in attentional processing of behaviorally significant events: evidence from simultaneous depth and scalp EEG. Brain Struct Funct. 2018;223:461-474 pubmed publisher
    ..These patients had externalized electrodes in the subthalamic nucleus (STN), the ventrolateral posterior thalamus (VLp) or the globus pallidus internus (GPi)...
  48. Hassan H, Dawah S, El Sheekh M. Monitoring the degradation capability of novel haloalkaliphilic tributyltin chloride (TBTCl) resistant bacteria from butyltin-polluted site. Rev Argent Microbiol. 2019;51:39-46 pubmed publisher
    ..After analysis of the 16S rRNA gene sequences the isolates were identified as Sphingobium sp. HS1, Stenotrophomonas chelatiphaga HS2 and Rhizobium borbori HS5...
  49. Chen Y, Hu B, Tan Z, Liu J, Yang Z, Li Z, et al. Selection of reference genes for quantitative real-time PCR normalization in creeping bentgrass involved in four abiotic stresses. Plant Cell Rep. 2015;34:1825-34 pubmed publisher
    ..The objective of this study was to determine the stability of expression for eight candidate reference genes (ACT, EF1a, TUB, UPL7, GAPDH, PP2A, PEPKR1, and CACS) in two tissues (roots and leaves) of a perennial grass species under ..
  50. Collomb Clerc A, Welter M. Effects of deep brain stimulation on balance and gait in patients with Parkinson's disease: A systematic neurophysiological review. Neurophysiol Clin. 2015;45:371-88 pubmed publisher
    Deep brain stimulation (DBS) of the subthalamic nucleus (STN) and internal globus pallidus (GPi) deep brain stimulation (DBS) provides an efficient treatment for the alleviation of motor signs in patients with Parkinson's disease...
  51. Sobstyl M, ZÄ…bek M. Deep brain stimulation for intractable tardive dystonia: Literature overview. Neurol Neurochir Pol. 2016;50:114-22 pubmed publisher
    ..GPi was the target in 55 patients, while subthalamic nucleus (STN) was the target in the remaining 4...
  52. Flores Alves dos Santos J, Tezenas du Montcel S, Gargiulo M, Béhar C, Montel S, Hergueta T, et al. Tackling psychosocial maladjustment in Parkinson's disease patients following subthalamic deep-brain stimulation: A randomised clinical trial. PLoS ONE. 2017;12:e0174512 pubmed publisher
    Subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment for the motor and non-motor signs of Parkinson's disease (PD), however, psychological disorders and social maladjustment have been reported in about one third ..
  53. Jia Q, Gao L, Zhang J, Wu T, Chan P. Altered functional connectivity of the subthalamic nucleus during self-initiated movement in Parkinson's disease. J Neuroradiol. 2018;45:249-255 pubmed publisher
    ..functional magnetic resonance imaging (fMRI) to investigate the functional connectivity of the subthalamic nucleus (STN) during self-initiated movement in patients with PD...
  54. Sharma M, Deogaonkar M. Accuracy and safety of targeting using intraoperative "O-arm" during placement of deep brain stimulation electrodes without electrophysiological recordings. J Clin Neurosci. 2016;27:80-6 pubmed publisher
    ..Twenty eight DBS leads (globus pallidus internus [GPi], n=13; subthalamic nucleus [STN], n=9; ventralis intermedius nucleus [VIM], n=6) were implanted in 20 patients using the stereotactic Leksell frame ..
  55. Rouhollahi K, Emadi Andani M, Karbassi S, Izadi I. Designing a robust backstepping controller for rehabilitation in Parkinson's disease: a simulation study. IET Syst Biol. 2016;10:136-46 pubmed publisher
    ..this end, two controllers are designed and implemented in globus pallidus internal (GPi) and subthalamic nucleus (STN) in the brain...
  56. Mesce K, Alania M, Gaudry Q, Puhl J. The stomatogastric nervous system of the medicinal leech: its anatomy, physiology and associated aminergic neurons. J Exp Biol. 2018;221: pubmed publisher
    ..and characteristics of five stomatogastric ganglia (STGs) comprising the visceral stomatogastric nervous system (STN) of the leech...
  57. Damier P. Why do Parkinson's Disease Patients Sometimes Make Wrong Decisions?. J Parkinsons Dis. 2015;5:637-42 pubmed publisher
    ..Dysfunction of the subthalamic nucleus (STN) induced by dopamine replacement or by deep brain stimulation is another mechanism that can alter decision making...
  58. Chen C, Xie T, Ye S, Jensen A, Eilenberg J. Selection of reference genes for expression analysis in the entomophthoralean fungus Pandora neoaphidis. Braz J Microbiol. 2016;47:259-65 pubmed publisher
    ..414) and EF1 (3). The 18S was, therefore, the most suitable reference gene for real-time RT-PCR analysis of gene expression under all conditions. These results will support further studies on gene expression in P. neoaphidis. ..
  59. Stakheev A, Khairulina D, Zavriev S. Four-locus phylogeny of Fusarium avenaceum and related species and their species-specific identification based on partial phosphate permease gene sequences. Int J Food Microbiol. 2016;225:27-37 pubmed publisher
    ..Quantitative PCR approach was applied to estimate the contamination rate of 17 naturally infected oat and barley samples, previously characterized by microbiological procedures. ..
  60. Min H, Ross E, Jo H, Cho S, Settell M, Jeong J, et al. Dopamine Release in the Nonhuman Primate Caudate and Putamen Depends upon Site of Stimulation in the Subthalamic Nucleus. J Neurosci. 2016;36:6022-9 pubmed publisher
    Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for medically refractory Parkinson's disease...
  61. Liepelt A, Naarmann de Vries I, Simons N, Eichelbaum K, Föhr S, Archer S, et al. Identification of RNA-binding Proteins in Macrophages by Interactome Capture. Mol Cell Proteomics. 2016;15:2699-714 pubmed publisher
    ..prostaglandin E2 synthase 3 (PTGES3) activity, and the hematopoietic cell-specific LYN substrate 1 (HCLS1 or HS1), a hematopoietic cell-specific adapter molecule, as novel macrophage RBPs...
  62. Bao W, Qu Y, Shan X, Wan Y. Screening and Validation of Housekeeping Genes of the Root and Cotyledon of Cunninghamia lanceolata under Abiotic Stresses by Using Quantitative Real-Time PCR. Int J Mol Sci. 2016;17: pubmed publisher
    ..on the results of database analysis and transcriptome sequencing, we have chosen five candidate HKGs (Actin, GAPDH, EF1a, 18S rRNA, and UBQ) with conservative sequences in the Chinese fir and related species for quantitative analysis...
  63. Constantinescu R, Eriksson B, Jansson Y, Johnels B, Holmberg B, Gudmundsdottir T, et al. Key clinical milestones 15 years and onwards after DBS-STN surgery-A retrospective analysis of patients that underwent surgery between 1993 and 2001. Clin Neurol Neurosurg. 2017;154:43-48 pubmed publisher
    Subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment for motor fluctuations in Parkinson's disease (PD), but does not halt disease progression...
  64. Kwon W, Kim J, Lee J, Lim B, Lee I, Koh S, et al. Microelectrode recording (MER) findings during sleep-awake anesthesia using dexmedetomidine in deep brain stimulation surgery for Parkinson's disease. Clin Neurol Neurosurg. 2016;143:27-33 pubmed publisher
    ..subcortical nuclei from 8 consecutive IPD patients whom had DBS at the GPi (6 patients) and subthalamic nucleus (STN) (2 patients) were retrospectively reviewed...
  65. Munkley J, Livermore K, Rajan P, Elliott D. RNA splicing and splicing regulator changes in prostate cancer pathology. Hum Genet. 2017;136:1143-1154 pubmed publisher
    ..ST6GALNAC1 encodes a sialyltransferase that catalyses the synthesis of the cancer-associated sTn antigen important for cell mobility...
  66. Byun H, Suh D, Jeong Y, Wee H, Kim J, Kim W, et al. Plasmid vectors harboring cellular promoters can induce prolonged gene expression in hematopoietic and mesenchymal progenitor cells. Biochem Biophys Res Commun. 2005;332:518-23 pubmed
    ..These results indicate that the use of cellular promoters such as those for EF-1alpha and ubiquitin C might direct prolonged gene expression in hematopoietic and mesenchymal progenitor cells. ..
  67. Cui H, Schlesinger J, Schoenhals S, Tönjes M, Dunkel I, Meierhofer D, et al. Phosphorylation of the chromatin remodeling factor DPF3a induces cardiac hypertrophy through releasing HEY repressors from DNA. Nucleic Acids Res. 2016;44:2538-53 pubmed publisher
    ..Thus, we present a novel pathway for pathological cardiac hypertrophy, whose inhibition is a long-term therapeutic goal for the treatment of the course of heart failure. ..
  68. Takamori L, Pereira A, Maia Souza G, Vieira L, Ferreira Ribas A. Identification of Endogenous Reference Genes for RT-qPCR Expression Analysis in Urochloa brizantha Under Abiotic Stresses. Sci Rep. 2017;7:8502 pubmed publisher
    ..The expression of Rubisco large subunit gene was normalized against the most stable gene selected by ReFfinder for each stress. ..
  69. Kawamura M, Endo C, Sakurada A, Hoshi F, Notsuda H, Kondo T. The prognostic significance of eukaryotic elongation factor 1 alpha-2 in non-small cell lung cancer. Anticancer Res. 2014;34:651-8 pubmed
    Eukaryotic elongation factor 1 alpha-2 (eEF1A2) has been recently shown to be a putative oncogene of lung cancer. We analyzed the expression and prognostic significance of eEF1A2 in 69 primary non-small cell lung cancer (NSCLC) cases...
  70. Haugstad K, Hadjialirezaei S, Stokke B, Brewer C, Gerken T, Burchell J, et al. Interactions of mucins with the Tn or Sialyl Tn cancer antigens including MUC1 are due to GalNAc-GalNAc interactions. Glycobiology. 2016;26:1338-1350 pubmed
    ..mechanism(s) underlying the enhanced self-interactions of mucins possessing the Tn (GalNAcα1-Ser/Thr) or STn (NeuNAcα2-6GalNAcα1-Ser/Thr) cancer markers were investigated using optical tweezers (OT)...
  71. Lee H, Weitz A, Bernal Casas D, Duffy B, Choy M, Kravitz A, et al. Activation of Direct and Indirect Pathway Medium Spiny Neurons Drives Distinct Brain-wide Responses. Neuron. 2016;91:412-24 pubmed publisher
    ..Importantly, positive and negative signals within the striatum, thalamus, GPi, and STN were all associated with increases and decreases in single-unit activity, respectively...
  72. Wade C, Kallupi M, Hernandez D, Breysse E, de Guglielmo G, Crawford E, et al. High-Frequency Stimulation of the Subthalamic Nucleus Blocks Compulsive-Like Re-Escalation of Heroin Taking in Rats. Neuropsychopharmacology. 2017;42:1850-1859 pubmed publisher
    ..provide preclinical evidence of the therapeutic potential of high-frequency stimulation of the subthalamic nucleus (STN HFS) for heroin addiction...
  73. Goelz L, David F, Sweeney J, Vaillancourt D, Poizner H, Metman L, et al. The effects of unilateral versus bilateral subthalamic nucleus deep brain stimulation on prosaccades and antisaccades in Parkinson's disease. Exp Brain Res. 2017;235:615-626 pubmed publisher
    Unilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) in patients with Parkinson's disease improves skeletomotor function assessed clinically, and bilateral STN DBS improves motor function to a significantly greater ..
  74. Golshan H, Hebb A, Hanrahan S, Nedrud J, Mahoor M. A hierarchical structure for human behavior classification using STN local field potentials. J Neurosci Methods. 2018;293:254-263 pubmed publisher
    ..a human behavior classification using local field potential (LFP) signals recorded from subthalamic nuclei (STN)...
  75. Nambu A, Tokuno H, Hamada I, Kita H, Imanishi M, Akazawa T, et al. Excitatory cortical inputs to pallidal neurons via the subthalamic nucleus in the monkey. J Neurophysiol. 2000;84:289-300 pubmed
    ..cortices on the activity of globus pallidus (GP) neurons, especially mediated by the subthalamic nucleus (STN), have been characterized...
  76. Hamey J, Wienert B, Quinlan K, Wilkins M. METTL21B Is a Novel Human Lysine Methyltransferase of Translation Elongation Factor 1A: Discovery by CRISPR/Cas9 Knockout. Mol Cell Proteomics. 2017;16:2229-2242 pubmed publisher
    ..Recombinant METTL21B was shown in vitro to catalyze methylation on lysine 165 in eEF1A1 and eEF1A2, confirming it as the methyltransferase responsible for this methylation site...
  77. Tsuboi T, Watanabe H, Tanaka Y, Ohdake R, Hattori M, Kawabata K, et al. Early detection of speech and voice disorders in Parkinson's disease patients treated with subthalamic nucleus deep brain stimulation: a 1-year follow-up study. J Neural Transm (Vienna). 2017;124:1547-1556 pubmed publisher
    ..previously reported that Parkinson's disease (PD) patients treated with subthalamic nucleus deep brain stimulation (STN-DBS) had distinct phenotypes of speech and voice disorders: hypokinetic dysarthria, stuttering, breathy voice, ..
  78. Arrieta Aguirre I, Menéndez Manjón P, Cuétara M, Fernández de Larrinoa I, García Ruiz J, Moragues M. Sequencing of FKS Hot Spot 1 from Saprochaete capitata To Search for a Relationship to Reduced Echinocandin Susceptibility. Antimicrob Agents Chemother. 2018;62: pubmed publisher
    ..capitata hot spot 1 region of the FKS gene (FKS HS1), which codifies for the catalytic subunit of β-1,3-d-glucan synthase, the target of echinocandins...
  79. Anderson D, Osting B, Vorwerk J, Dorval A, Butson C. Optimized programming algorithm for cylindrical and directional deep brain stimulation electrodes. J Neural Eng. 2017;: pubmed publisher
    ..We demonstrate our algorithm's ability in an example programming case that targets the subthalamic nucleus (STN) for the treatment of Parkinson's disease for three lead designs: the Medtronic 3389 (four cylindrical contacts), ..
  80. Pöting A, Danker K, Hartmann L, Koster M, Wedlich D, Knochel W. Two different mRNAs coding for identical elongation factor 1 alpha (EF-1 alpha) polypeptides in Xenopus laevis embryos. Differentiation. 1990;44:103-10 pubmed
    ..A high amount of EF-1 alpha mRNA was detected in previtellogenic oocytes. At later stages of embryonic development, EF-1 alpha mRNA was found to be accumulated in translationally active tissues...
  81. Sarfraz R, Ahmad M, Mahmood A, Akram M, Abrar A. Development of ?-cyclodextrin-based hydrogel microparticles for solubility enhancement of rosuvastatin: an in vitro and in vivo evaluation. Drug Des Devel Ther. 2017;11:3083-3096 pubmed publisher
    ..Formulations (HS1-HS9) have shown entrapment efficiency between 83.50%±0.30% and 88.50%±0...
  82. Zavala B, Tan H, Little S, Ashkan K, Green A, Aziz T, et al. Decisions Made with Less Evidence Involve Higher Levels of Corticosubthalamic Nucleus Theta Band Synchrony. J Cogn Neurosci. 2016;28:811-25 pubmed publisher
    ..sensory conflict, medial pFC oscillations in the theta band (<8 Hz) drive those of the subthalamic nucleus (STN), and this is thought to increase the threshold of evidence needed for one competing response to be selected over ..
  83. Zhu H, Wang Z, Jin J, Pei X, Zhao Y, Wu H, et al. Parkinson's disease-like forelimb akinesia induced by BmK I, a sodium channel modulator. Behav Brain Res. 2016;308:166-76 pubmed publisher
    ..vital role in the abnormal electrical activity of neurons in the globus pallidus (GP) and the subthalamic nucleus (STN) in PD...
  84. Birchall E, Walker H, Cutter G, Guthrie S, Joop A, Memon R, et al. The effect of unilateral subthalamic nucleus deep brain stimulation on depression in Parkinson's disease. Brain Stimul. 2017;10:651-656 pubmed publisher
    ..Both unilateral and bilateral subthalamic (STN) deep brain stimulation (DBS) effectively treat the motor symptoms of PD, but questions remain regarding the impact ..
  85. Ghahremani A, Wessel J, Udupa K, Neagu B, Zhuang P, Saha U, et al. Stopping and slowing manual and spoken responses: Similar oscillatory signatures recorded from the subthalamic nucleus. Brain Lang. 2018;176:1-10 pubmed publisher
    ..responses is thought to be implemented by a frontal-subcortical network, which includes the subthalamic nucleus (STN)...
  86. Zavala B, Jang A, Zaghloul K. Human subthalamic nucleus activity during non-motor decision making. elife. 2017;6: pubmed publisher
    Recent studies have implicated the subthalamic nucleus (STN) in decisions that involve inhibiting movements. Many of the decisions that we make in our daily lives, however, do not involve any motor actions...
  87. Dafsari H, Reker P, Stalinski L, Silverdale M, Rizos A, Ashkan K, et al. Quality of life outcomes after subthalamic stimulation in Parkinson's disease depends on age. Mov Disord. 2017;: pubmed publisher
    The purpose of this study was to investigate how quality of life outcome after bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) in Parkinson's disease (PD) depends on age.
  88. Inui T, Kobayashi S, Ashikari Y, Sato R, Endo W, Uematsu M, et al. Two cases of early-onset myoclonic seizures with continuous parietal delta activity caused by EEF1A2 mutations. Brain Dev. 2016;38:520-4 pubmed publisher
    Mutations in the elongation factor 1 alpha 2 (EEF1A2) gene have recently been shown to cause severe intellectual disability with early-onset epilepsy. The specific manifestations of mutations in this gene remain unknown...
  89. Qiu F, Huang Y, Chen D, Li F, Wu Y, Wu W, et al. Eukaryotic elongation factor-1? 2 knockdown inhibits hepatocarcinogenesis by suppressing PI3K/Akt/NF-?B signaling. World J Gastroenterol. 2016;22:4226-37 pubmed publisher
    To assess the impact of eukaryotic elongation factor 1 alpha 2 (eEF1A2) on hepatocellular carcinoma (HCC) cell proliferation, apoptosis, migration and invasion, and determine the underlying mechanisms...
  90. Escobar Sanabria D, Johnson L, Nebeck S, Zhang J, Johnson M, Baker K, et al. Parkinsonism and vigilance: alteration in neural oscillatory activity and phase-amplitude coupling in the basal ganglia and motor cortex. J Neurophysiol. 2017;118:2654-2669 pubmed publisher
    ..and vigilance altered oscillatory activity and PAC within the primary motor cortex (M1), subthalamic nucleus (STN), and globus pallidus (GP) in two nonhuman primates...
  91. Mamaligas A, Ford C. Revealing a Role for NMDA Receptors in Regulating STN Inputs following the Loss of Dopamine. Neuron. 2017;95:1227-1229 pubmed publisher
    In this issue of Neuron, Chu et al. (2017) show that dopamine depletion using a 6-OHDA model causes a decrease in hyperdirect inputs from the motor cortex directly to the STN and that rescuing this loss alleviates Parkinsonian symptoms.
  92. Nazzaro J, Pahwa R, Lyons K. Symptomatic, non-infectious, non-hemorrhagic edema after subthalamic nucleus deep brain stimulation surgery for Parkinson's disease. J Neurol Sci. 2017;383:42-46 pubmed publisher
    We review our experience with Parkinson's disease (PD) patients who underwent subthalamic nucleus (STN) deep brain stimulation (DBS) and then developed noninfectious, non-hemorrhagic, delayed, symptomatic brain edema associated with a ..