Gene Symbol: EEF1A1
Description: eukaryotic translation elongation factor 1 alpha 1
Alias: CCS-3, CCS3, EE1A1, EEF-1, EEF1A, EF-Tu, EF1A, GRAF-1EF, HNGC:16303, LENG7, PTI1, eEF1A-1, elongation factor 1-alpha 1, CTCL tumor antigen, EF-1-alpha-1, EF1a-like protein, cervical cancer suppressor 3, elongation factor 1 alpha subunit, elongation factor Tu, eukaryotic elongation factor 1 A-1, eukaryotic translation elongation factor 1 alpha 1-like 14, glucocorticoid receptor AF-1 specific elongation factor, leukocyte receptor cluster (LRC) member 7, leukocyte receptor cluster member 7, prostate tumor-inducing protein 1, translation elongation factor 1 alpha 1-like 14
Species: human
Products:     EEF1A1

Top Publications

  1. Scaggiante B, Dapas B, Grassi G, Manzini G. Interaction of G-rich GT oligonucleotides with nuclear-associated eEF1A is correlated with their antiproliferative effect in haematopoietic human cancer cell lines. FEBS J. 2006;273:1350-61 pubmed
    ..The cytotoxicity of these oligomers was related to their binding to the nuclear-associated eEF1A protein, but not to the recognition of nucleolin or other proteins...
  2. Cimarelli A, Luban J. Translation elongation factor 1-alpha interacts specifically with the human immunodeficiency virus type 1 Gag polyprotein. J Virol. 1999;73:5388-401 pubmed
  3. Lund A, Knudsen S, Vissing H, Clark B, Tommerup N. Assignment of human elongation factor 1alpha genes: EEF1A maps to chromosome 6q14 and EEF1A2 to 20q13.3. Genomics. 1996;36:359-61 pubmed
    The human elongation factor 1alpha gene family consists of at least 2 actively transcribed genes, EEF1A and EEF1A2, and more than 18 homologous loci...
  4. Mingot J, Vega S, Cano A, Portillo F, Nieto M. eEF1A mediates the nuclear export of SNAG-containing proteins via the Exportin5-aminoacyl-tRNA complex. Cell Rep. 2013;5:727-37 pubmed publisher
    ..aminoacylated, the Exportin5-aminoacyl (aa)-tRNA complex recruits and coexports the translation elongation factor eEF1A. Here, we show that eEF1A binds to Snail transcription factors when bound to their main target, the E-cadherin ..
  5. Frum R, Busby S, Ramamoorthy M, Deb S, Shabanowitz J, Hunt D, et al. HDM2-binding partners: interaction with translation elongation factor EF1alpha. J Proteome Res. 2007;6:1410-7 pubmed
    ..Because a CTCL tumor antigen HD-CL-08 has high degree of homology with EF1alpha, we confirmed interaction of HDM2 with EF1alpha by ..
  6. Eckhardt K, Troger J, Reissmann J, Katschinski D, Wagner K, Stengel P, et al. Male germ cell expression of the PAS domain kinase PASKIN and its novel target eukaryotic translation elongation factor eEF1A1. Cell Physiol Biochem. 2007;20:227-40 pubmed
    ..By yeast two-hybrid screening, we identified the multifunctional eukaryotic translation elongation factor eEF1A1 as a novel interaction partner of PASKIN...
  7. Bohnsack M, Regener K, Schwappach B, Saffrich R, Paraskeva E, Hartmann E, et al. Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm. EMBO J. 2002;21:6205-15 pubmed
    ..We identify here the translation elongation factor 1A (eEF1A) as the predominant nuclear export substrate of RanBP21/exportin 5 (Exp5)...
  8. Yan G, You B, Chen S, Liao J, Sun J. Tumor necrosis factor-alpha downregulates endothelial nitric oxide synthase mRNA stability via translation elongation factor 1-alpha 1. Circ Res. 2008;103:591-7 pubmed publisher
    ..protein identified 3 peptides that comprise the peptide sequence of translation elongation factor 1-alpha 1 (eEF1A1)...
  9. Shen R, Su Z, Olsson C, Fisher P. Identification of the human prostatic carcinoma oncogene PTI-1 by rapid expression cloning and differential RNA display. Proc Natl Acad Sci U S A. 1995;92:6778-82 pubmed
    ..The approaches used, rapid expression cloning with the CREF-Trans 6 system and the DD strategy, should prove widely applicable for identifying and cloning additional human oncogenes. ..

More Information

Publications111 found, 100 shown here

  1. Calado A, Treichel N, Müller E, Otto A, Kutay U. Exportin-5-mediated nuclear export of eukaryotic elongation factor 1A and tRNA. EMBO J. 2002;21:6216-24 pubmed
    ..We have identified eukaryotic elongation factor 1A (eEF1A) and tRNA as RanGTP-dependent binding partners of exportin-5 (Exp5)...
  2. Carvalho M, Carvalho J, Merrick W. Biological characterization of various forms of elongation factor 1 from rabbit reticulocytes. Arch Biochem Biophys. 1984;234:603-11 pubmed
    ..The results presented in this report, along with studies from other laboratories, strengthen the hypothesis that the general mechanism of the elongation cycle is similar in eucaryotes and procaryotes. ..
  3. Kobayashi Y, Yonehara S. Novel cell death by downregulation of eEF1A1 expression in tetraploids. Cell Death Differ. 2009;16:139-50 pubmed publisher
    ..The cell death was associated with downregulation of eukaryotic translation elongation factor-1 alpha 1 (eEF1A1/EF-1alpha) expression in conjunction with accumulation of its mRNA in processing bodies (P bodies)...
  4. Petrushenko Z, Budkevich T, Shalak V, Negrutskii B, El skaya A. Novel complexes of mammalian translation elongation factor eEF1A.GDP with uncharged tRNA and aminoacyl-tRNA synthetase. Implications for tRNA channeling. Eur J Biochem. 2002;269:4811-8 pubmed
    Multimolecular complexes involving the eukaryotic elongation factor 1A (eEF1A) have been suggested to play an important role in the channeling (vectorial transfer) of tRNA during protein synthesis [Negrutskii, B.S. & El'skaya, A.V...
  5. Lamberti A, Longo O, Marra M, Tagliaferri P, Bismuto E, Fiengo A, et al. C-Raf antagonizes apoptosis induced by IFN-alpha in human lung cancer cells by phosphorylation and increase of the intracellular content of elongation factor 1A. Cell Death Differ. 2007;14:952-62 pubmed
    ..The dynamic simulation of 3Dstructure of eEF-1A identified putative serine and threonine phosphorylation sites. In conclusion, the interaction between eEF-1A and C-Raf increases eEF-1A stability and induces a survival activity. ..
  6. Grassi G, Scaggiante B, Farra R, Dapas B, Agostini F, Baiz D, et al. The expression levels of the translational factors eEF1A 1/2 correlate with cell growth but not apoptosis in hepatocellular carcinoma cell lines with different differentiation grade. Biochimie. 2007;89:1544-52 pubmed
    Despite the involvement of the elongation factors eEF1A (eEF1A1 and eEF1A2) in the development of different cancers no information is available on their possible contribution to the biology of hepatocellular carcinoma (HCC)...
  7. Koiwai K, Maezawa S, Hayano T, Iitsuka M, Koiwai O. BPOZ-2 directly binds to eEF1A1 to promote eEF1A1 ubiquitylation and degradation and prevent translation. Genes Cells. 2008;13:593-607 pubmed publisher
    ..We isolated a cDNA encoding eukaryotic elongation factor 1A1 (eEF1A1) as a BPOZ-2 binding protein by screening a human thymus cDNA library using a yeast two-hybrid system...
  8. Uetsuki T, Naito A, Nagata S, Kaziro Y. Isolation and characterization of the human chromosomal gene for polypeptide chain elongation factor-1 alpha. J Biol Chem. 1989;264:5791-8 pubmed
    ..By using nuclear extracts from HeLa cells, the promoter of human elongation factor-1 alpha gene could stimulate in vitro transcription better than the adenovirus major late promoter. ..
  9. Sanders J, Brandsma M, Janssen G, Dijk J, Moller W. Immunofluorescence studies of human fibroblasts demonstrate the presence of the complex of elongation factor-1 beta gamma delta in the endoplasmic reticulum. J Cell Sci. 1996;109 ( Pt 5):1113-7 pubmed
    ..The guanine nucleotide-binding subunit of EF-1, EF-1 alpha, shows a more diffuse distribution throughout the cytoplasm and is, in addition, associated with the nucleus. ..
  10. Mansilla F, Hansen L, Jakobsen H, Kjeldgaard N, Clark B, Knudsen C. Deconstructing PTI-1: PTI-1 is a truncated, but not mutated, form of translation elongatin factor 1A1, eEF1A1. Biochim Biophys Acta. 2005;1727:116-24 pubmed
    ..We have found that the PTI-1 transcript may encode a truncated, but not mutated, form of the human isoform eEF1A1. Additionally, the 5' UTR sequence of PTI-1 from genomic DNA of different cell lines and blood samples varies from ..
  11. Kanibolotsky D, Novosyl na O, Abbott C, Negrutskii B, El skaya A. Multiple molecular dynamics simulation of the isoforms of human translation elongation factor 1A reveals reversible fluctuations between "open" and "closed" conformations and suggests specific for eEF1A1 affinity for Ca2+-calmodul. BMC Struct Biol. 2008;8:4 pubmed publisher
    ..We reasoned that the background for the functional difference of eEF1A1 and eEF1A2 might lie in changes of dynamics of the isoforms...
  12. Liu G, Grant W, Persky D, Latham V, Singer R, Condeelis J. Interactions of elongation factor 1alpha with F-actin and beta-actin mRNA: implications for anchoring mRNA in cell protrusions. Mol Biol Cell. 2002;13:579-92 pubmed
    ..Taken together, these results implicate EF1alpha in the anchoring of beta-actin mRNA to the protrusion in crawling cells. ..
  13. Ampawong S, Isarangkul D, Reamtong O, Aramwit P. Adaptive effect of sericin on hepatic mitochondrial conformation through its regulation of apoptosis, autophagy and energy maintenance: a proteomics approach. Sci Rep. 2018;8:14943 pubmed publisher regulating apoptotic (NADH-ubiquinone oxidoreductase 75 kDa subunit) and autophagic (mitochondrial elongation factor Tu and prohibitin-2) proteins as well as energy maintenance proteins [haloacid dehalogenase-like hydrolase ..
  14. Gueugneau M, Coudy Gandilhon C, Gourbeyre O, Chambon C, Combaret L, Polge C, et al. Proteomics of muscle chronological ageing in post-menopausal women. BMC Genomics. 2014;15:1165 pubmed publisher
    ..None of them were previously recognized as differentially expressed in old muscles, and each may represent a novel starting point to elucidate the mechanisms of muscle chronological ageing in humans. ..
  15. Lu Y, Yuan M, Gao X, Kang T, Zhan S, Wan H, et al. Identification and validation of reference genes for gene expression analysis using quantitative PCR in Spodoptera litura (Lepidoptera: Noctuidae). PLoS ONE. 2013;8:e68059 pubmed publisher
    ..We believe that these results make an important contribution to gene analysis studies in S. litura and form the basis of further research on stable reference genes in S. litura and other organisms. ..
  16. Liew Y, Awang Hamat R, van Belkum A, Chong P, Neela V. Comparative Exoproteomics and Host Inflammatory Response in Staphylococcus aureus Skin and Soft Tissue Infections, Bacteremia, and Subclinical Colonization. Clin Vaccine Immunol. 2015;22:593-603 pubmed publisher
    ..hydroxymethyltransferase [PanB], cysteine synthase A, an N-acetyltransferase, four isoforms of elongation factor Tu [EF-Tu], and one signature protein spot that could not be reliably identified by MS/MS) were found to be ..
  17. Deng W, Yang Y, Gao P, Chen H, Wen W, Sun Q. Radiation-Resistant Micrococcus luteus SC1204 and Its Proteomics Change Upon Gamma Irradiation. Curr Microbiol. 2016;72:767-75 pubmed publisher
    ..alpha, phosphoglycerate kinase, cell division protein FtsZ, elongation factor Ts and Tu, translation elongation factor Tu and G, 30S ribosomal protein S1, histidyl-tRNA synthetase, and arginyl-tRNA synthetase, which were ..
  18. Pan Y, Li Q, Wang Z, Wang Y, Ma R, Zhu L, et al. Genes associated with thermosensitive genic male sterility in rice identified by comparative expression profiling. BMC Genomics. 2014;15:1114 pubmed publisher
    ..5B (eIF5B), ribosomal proteins (L37, L1p/L10e, L27 and L24), aminoacyl-tRNA synthetases (ARSs), eukaryotic elongation factor Tu (eEF-Tu) and a peptide chain release factor protein involved in translation...
  19. V Patankar H, M Assaha D, Al Yahyai R, Sunkar R, Yaish M. Identification of Reference Genes for Quantitative Real-Time PCR in Date Palm (Phoenix dactylifera L.) Subjected to Drought and Salinity. PLoS ONE. 2016;11:e0166216 pubmed publisher
    ..SUBUNIT RIBOSOMAL RNA (25S), YT521 and 18S ribosomal RNA (18S); and UBQ, ACTIN and ELONGATION FACTOR 1-ALPHA (eEF1a) were stable in leaves and roots, respectively, under salt stress...
  20. Kohutiar M, Eckhardt A, Miksik I, Santorová P, Wilhelm J. Proteomic analysis of peroxynitrite-induced protein nitration in isolated beef heart mitochondria. Physiol Res. 2018;67:239-250 pubmed
    ..proteins such as cytochrome b-c1 complex subunit 1, NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, elongation factor Tu, NADH dehydrogenase [ubiquinone] flavoprotein 2, heat shock protein beta-1 and NADH dehydrogenase [..
  21. Muratoglu H, Nalcacioglu R, Arif B, Demirbag Z. Genome-wide analysis of differential mRNA expression of Amsacta moorei entomopoxvirus, mediated by the gene encoding a viral protein kinase (AMV197). Virus Res. 2016;215:25-36 pubmed publisher
    ..cellular genes including metabolism of apoptosis (Nedd2-like caspase, hemolin and elongation factor-1 alpha (ef1a) gene) was downregulated in the absence of amv197...
  22. Lou Q, Cao S, Xu W, Zhang Y, Qin Z, Wei W. Molecular characterization and mRNA expression of ribosomal protein L8 in Rana nigromaculata during development and under exposure to hormones. J Environ Sci (China). 2014;26:2331-9 pubmed publisher
    ..Then, we examined the stability of mRNA expression during development. Compared with elongation factor 1 alpha 1, another common housekeeping gene, neither stage-specific nor tissue-specific expression of the rpl8 ..
  23. Nagai K, Domon H, Maekawa T, Oda M, Hiyoshi T, Tamura H, et al. Pneumococcal DNA-binding proteins released through autolysis induce the production of proinflammatory cytokines via toll-like receptor 4. Cell Immunol. 2018;325:14-22 pubmed publisher
    ..Liquid chromatography tandem-mass spectrometry analysis identified that chaperone protein DnaK, elongation factor Tu (EF-Tu), and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) were released with pneumococcal DNA by ..
  24. Mishra V, Passari A, Chandra P, Leo V, Kumar B, Uthandi S, et al. Determination and production of antimicrobial compounds by Aspergillus clavatonanicus strain MJ31, an endophytic fungus from Mirabilis jalapa L. using UPLC-ESI-MS/MS and TD-GC-MS analysis. PLoS ONE. 2017;12:e0186234 pubmed publisher
  25. Itagaki K, Naito T, Iwakiri R, Haga M, Miura S, Saito Y, et al. Eukaryotic translation elongation factor 1A induces anoikis by triggering cell detachment. J Biol Chem. 2012;287:16037-46 pubmed publisher
    ..Eukaryotic elongation factor 1A (eEF1A) was identified as a membrane receptor for the exposed antiadhesive site...
  26. Li D, Wei T, Rawle D, Qin F, Wang R, Soares D, et al. Specific Interaction between eEF1A and HIV RT Is Critical for HIV-1 Reverse Transcription and a Potential Anti-HIV Target. PLoS Pathog. 2015;11:e1005289 pubmed publisher
    ..that association between the eEF1 and RTC complexes occurs by a strong and direct interaction between the subunit eEF1A and reverse transcriptase (RT)...
  27. Li S, Loor J, Liu H, Liu L, Hosseini A, Zhao W, et al. Optimal ratios of essential amino acids stimulate β-casein synthesis via activation of the mammalian target of rapamycin signaling pathway in MAC-T cells and bovine mammary tissue explants. J Dairy Sci. 2017;100:6676-6688 pubmed publisher
    ..the OPAA upregulated the mRNA expression of SLC1A5 and SLC7A5 but downregulated the expression of IRS1, AKT3, EEF1A1, and EEF2 compared with the control...
  28. Belyi Y, Stahl M, Sovkova I, Kaden P, Luy B, Aktories K. Region of elongation factor 1A1 involved in substrate recognition by Legionella pneumophila glucosyltransferase Lgt1: identification of Lgt1 as a retaining glucosyltransferase. J Biol Chem. 2009;284:20167-74 pubmed publisher
    ..This enzyme modifies eukaryotic elongation factor 1A (eEF1A) at serine 53, which leads to inhibition of protein synthesis and death of target cells...
  29. Lee D, Brown J, Rosa M, Brown L, Perry R, Washington T, et al. Translational machinery of mitochondrial mRNA is promoted by physical activity in Western diet-induced obese mice. Acta Physiol (Oxf). 2016;218:167-177 pubmed publisher
    ..Mitochondrial mRNA translation machinery including initiation factors (mtIF2/3), elongation factor Tu (TUFM) and translational activator (TACO1), and mitochondria-encoded proteins (CytB and ND4) was assessed ..
  30. Terahara N, Tulum I, Miyata M. Transformation of crustacean pathogenic bacterium Spiroplasma eriocheiris and expression of yellow fluorescent protein. Biochem Biophys Res Commun. 2017;487:488-493 pubmed publisher
    ..The transformation efficiency achieved was 1.6 × 10-5 colony forming unit (CFU) for 1 ?g DNA, enabling the expression of the enhanced yellow fluorescent protein (EYFP). ..
  31. Xu K, Zhang Y, Han B, Bai Y, Xiong Y, Song Y, et al. Suppression subtractive hybridization identified differentially expressed genes in colorectal cancer: microRNA-451a as a novel colorectal cancer-related gene. Tumour Biol. 2017;39:1010428317705504 pubmed publisher
    ..They were BCAP31, EEF1A1, CDC20, WDR6, TUFM, RPL13, and RPL7A...
  32. Mwaba I, Rey M. Nitric oxide associated protein 1 is associated with chloroplast perturbation and disease symptoms in Nicotiana benthamiana infected with South African cassava mosaic virus. Virus Res. 2017;238:75-83 pubmed publisher
    ..of chloroplast translation factors (chloroplast RNA binding, chloroplast elongation factor G, translation elongation factor Tu, translation initiation factor 3-2, plastid-specific ribosomal protein 6 and plastid ribosome recycling ..
  33. Schon I, Higuti J, Patel T, Martens K. Aquatic long-distance dispersal and vicariance shape the evolution of an ostracod species complex (Crustacea) in four major Brazilian floodplains. Mol Phylogenet Evol. 2018;121:86-97 pubmed publisher
  34. Pungaliya P, Kulkarni D, Park H, Marshall H, Zheng H, Lackland H, et al. TOPORS functions as a SUMO-1 E3 ligase for chromatin-modifying proteins. J Proteome Res. 2007;6:3918-23 pubmed
    ..Transfection studies confirmed mammalian Sin3A as a sumoylation substrate for TOPORS. These findings suggest that TOPORS may function as a tumor suppressor by regulating mSin3A and other proteins involved in chromatin modification. ..
  35. Wang S, Wang Y, Sun X, Zhang Z, Liu T, Gadahi J, et al. Protective immunity against acute toxoplasmosis in BALB/c mice induced by a DNA vaccine encoding Toxoplasma gondii elongation factor 1-alpha. BMC Infect Dis. 2015;15:448 pubmed publisher
    ..gondii infection, indicating that TgEF-1α is a promising vaccine candidate against acute toxoplasmosis. ..
  36. Hakimi H, Yamagishi J, Kegawa Y, Kaneko O, Kawazu S, Asada M. Establishment of transient and stable transfection systems for Babesia ovata. Parasit Vectors. 2016;9:171 pubmed publisher
    ..These results confirm successful development of a stable transfection system for B. ovata. The current study provides a fundamental molecular tool to aid in molecular and cellular studies of B. ovata. ..
  37. Carnielli C, Artier J, de Oliveira J, Novo Mansur M. Xanthomonas citri subsp. citri surface proteome by 2D-DIGE: Ferric enterobactin receptor and other outer membrane proteins potentially involved in citric host interaction. J Proteomics. 2017;151:251-263 pubmed publisher
    ..b>Elongation factor Tu, OmpA-related proteins, Oar proteins and some Ton-B dependent receptors were found in spots decreased in ..
  38. Xiang Q, Hong D, Liao Y, Cao Y, Liu M, Pang J, et al. Overexpression of Gremlin1 in Mesenchymal Stem Cells Improves Hindlimb Ischemia in Mice by Enhancing Cell Survival. J Cell Physiol. 2017;232:996-1007 pubmed publisher
    ..The lentiviral vector, EF1a-GREM1, was constructed using the Multisite Gateway System and used to transduce MSCs...
  39. Marcos C, de Oliveira H, da Silva J, Assato P, Yamazaki D, da Silva R, et al. Identification and characterisation of elongation factor Tu, a novel protein involved in Paracoccidioides brasiliensis-host interaction. FEMS Yeast Res. 2016;16: pubmed
    ..The aim of this study was to characterise the involvement of elongation factor Tu (EF-Tu) in Paracoccidioides brasiliensis-host interaction...
  40. Xia X, Huo W, Wan R, Xia X, Du Q, Chang Z. Identification of housekeeping genes as references for quantitative real-time RT-PCR analysis in Misgurnus anguillicaudatus. J Genet. 2017;96:895-904 pubmed
    ..This study could provide useful guidelines that can be expected to aid M. anguillicaudatus researchers in their initial choice of housekeeping genes for future studies and enable more accurate normalization of gene expression data. ..
  41. Vera M, Pani B, Griffiths L, Muchardt C, Abbott C, Singer R, et al. The translation elongation factor eEF1A1 couples transcription to translation during heat shock response. elife. 2014;3:e03164 pubmed publisher
    ..b>eEF1A1 then associates with elongating RNA polymerase II and the 3'UTR of HSP70 mRNA, stabilizing it and facilitating its ..
  42. Garcia Esparcia P, Hernández Ortega K, Koneti A, Gil L, Delgado Morales R, Castaño E, et al. Altered machinery of protein synthesis is region- and stage-dependent and is associated with α-synuclein oligomers in Parkinson's disease. Acta Neuropathol Commun. 2015;3:76 pubmed publisher
    ..Altered levels of eIF3 and eIF1, and decrease eEF1A and eEF2 protein levels were observed in the frontal cortex in PD...
  43. Qayyum S, Sharma D, Bisht D, Khan A. Protein translation machinery holds a key for transition of planktonic cells to biofilm state in Enterococcus faecalis: A proteomic approach. Biochem Biophys Res Commun. 2016;474:652-659 pubmed publisher
    ..Protein translation elongation factor G, translation elongation factor Tu and ribosomal subunit interface proteins were underexpressed and UTP-glucose-1-phosphate uridylyl ..
  44. Assaf F, Schiller Y. The antiepileptic and ictogenic effects of optogenetic neurostimulation of PV-expressing interneurons. J Neurophysiol. 2016;116:1694-1704 pubmed publisher
    ..we expressed channelrhodopsin 2 in PV interneurons by locally injecting the Cre-dependent viral vector AAV2/1-EF1a-DIO-ChETA-EYFP into the S1 barrel cortex of PV-Cre mice...
  45. Tajerian M, Hung V, Khan H, Lahey L, Sun Y, Birklein F, et al. Identification of KRT16 as a target of an autoantibody response in complex regional pain syndrome. Exp Neurol. 2017;287:14-20 pubmed publisher
    ..LC-MS analysis provided us a list of potential targets, some of which were upregulated after fracture (KRT16, eEF1a1, and PRPH), while others showed subcellular-redistribution and increased membrane localization (ANXA2 and ENO3)...
  46. Kaçar B, Ge X, Sanyal S, Gaucher E. Experimental Evolution of Escherichia coli Harboring an Ancient Translation Protein. J Mol Evol. 2017;84:69-84 pubmed publisher approximately 700-million-year-old inferred ancestral variant of tufB, an essential gene encoding elongation factor Tu, and inserted it in a modern Escherichia coli genome in place of the native tufB gene...
  47. Oulhen N, Swartz S, Laird J, Mascaro A, Wessel G. Transient translational quiescence in primordial germ cells. Development. 2017;144:1201-1210 pubmed publisher
    ..We found that the mRNA of the translation factor eEF1A is excluded from the PGCs in a Nanos2-dependent manner, a consequence of a Nanos/Pumilio response element (PRE) in ..
  48. Sandoval Denis M, Sutton D, Martin Vicente A, Cano Lira J, Wiederhold N, Guarro J, et al. Cladosporium Species Recovered from Clinical Samples in the United States. J Clin Microbiol. 2015;53:2990-3000 pubmed publisher
    ..In vitro susceptibility testing of 92 isolates against nine antifungal drugs showed a variety of results but high activity overall for the azoles, echinocandins, and terbinafine. ..
  49. Ricci M, Andersen J, Joffe A, Watt M, Moez E, Dinu I, et al. Chronic Neuromotor Disability After Complex Cardiac Surgery in Early Life. Pediatrics. 2015;136:e922-33 pubmed publisher
    ..Shortening the waiting period and reducing preoperative plasma lactate levels at first CCS may assist in reducing the frequency of CND. ..
  50. Boratkó A, Péter M, Thalwieser Z, Kovács E, Csortos C. Elongation factor-1A1 is a novel substrate of the protein phosphatase 1-TIMAP complex. Int J Biochem Cell Biol. 2015;69:105-13 pubmed publisher
    ..Direct interaction of TIMAP with the eukaryotic elongation factor 1 A1 (eEF1A1) is shown by pull-down, LC-MS/MS, Far-Western and immunoprecipitations...
  51. Kim E, Kwak S, Hwang D, Yi E, Park K, Koo B, et al. The Level of Autoantibodies Targeting Eukaryote Translation Elongation Factor 1 α1 and Ubiquitin-Conjugating Enzyme 2L3 in Nondiabetic Young Adults. Diabetes Metab J. 2016;40:154-60 pubmed publisher
    The prevalence of novel type 1 diabetes mellitus (T1DM) antibodies targeting eukaryote translation elongation factor 1 alpha 1 autoantibody (EEF1A1-AAb) and ubiquitin-conjugating enzyme 2L3 autoantibody (UBE2L3-AAb) has been shown to be ..
  52. Schaeck M, De Spiegelaere W, De Craene J, Van den Broeck W, De Spiegeleer B, Burvenich C, et al. Laser capture microdissection of intestinal tissue from sea bass larvae using an optimized RNA integrity assay and validated reference genes. Sci Rep. 2016;6:21092 pubmed publisher
    ..According to the geNorm and Normfinder algorithms, ef1a, rpl13a, rps18 and faua were the most stable genes to be implemented as reference genes for an appropriate ..
  53. Chandler R, Williams I, Gibson A, Davidson C, Incao A, Hubbard B, et al. Systemic AAV9 gene therapy improves the lifespan of mice with Niemann-Pick disease, type C1. Hum Mol Genet. 2017;26:52-64 pubmed publisher deliver the NPC1 gene under the transcriptional control of the neuronal-specific (CamKII) or a ubiquitous (EF1a) promoter. The Npc1-/- mice that received a single dose of AAV9-CamKII-NPC1 as neonates (2...
  54. Yamazaki A, Yanagiba M, Naganuma T. Two novel Lipomycetaceous yeast species, Lipomyces okinawensis sp. nov. and Lipomyces yamanashiensis f.a., sp. nov., isolated from soil in the Okinawa and Yamanashi prefectures, Japan. Int J Syst Evol Microbiol. 2017;67:2941-2946 pubmed publisher
    ..nov. (type strain No.3-a(35)T=NBRC 110620T=CBS 14747T) and Lipomyces yamanashiensis f.a., sp. nov. (type strain No.313T=NBRC 110621T=CBS 14748T). ..
  55. Timm T, Annoscia G, Klein J, Lochnit G. The Eukaryotic Elongation Factor 1 Alpha (eEF1α) from the Parasite Leishmania infantum Is Modified with the Immunomodulatory Substituent Phosphorylcholine (PC). Molecules. 2017;22: pubmed publisher
    ..In this study we provide evidence that in this parasite the modification of eEF1α with PC may be essential for its function as an important virulence factor. ..
  56. Yue J, Shukla R, Accardi R, Zanella Cleon I, Siouda M, Cros M, et al. Cutaneous human papillomavirus type 38 E7 regulates actin cytoskeleton structure for increasing cell proliferation through CK2 and the eukaryotic elongation factor 1A. J Virol. 2011;85:8477-94 pubmed publisher
    ..HPV38 E7 is able to induce actin fiber disruption by binding directly to eukaryotic elongation factor 1A (eEF1A) and abolishing its effects on actin fiber formation...
  57. Tsai N, Wilkerson J, Guo W, Maksimova M, Demartino G, Cowan C, et al. Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95. Cell. 2012;151:1581-94 pubmed publisher
    ..Together, our findings reveal roles for multiple autism-linked genes in activity-dependent synapse elimination. ..
  58. Silva M, Knowles D, Suarez C. Identification of interchangeable cross-species function of elongation factor-1 alpha promoters in Babesia bigemina and Babesia bovis. Parasit Vectors. 2016;9:576 pubmed
    ..bigemina and B. bovis which is described for the first time in Babesia species. This study is of significance for development of interspecies stable transfection systems for B. bigemina and for B. bovis. ..
  59. Wang S, Lei C, Wang J, Ma J, Tang S, Wang C, et al. SPL33, encoding an eEF1A-like protein, negatively regulates cell death and defense responses in rice. J Exp Bot. 2017;68:899-913 pubmed publisher
    ..SPL33 encodes a eukaryotic translation elongation factor 1 alpha (eEF1A)-like protein consisting of a non-functional zinc finger domain and three functional EF-Tu domains...
  60. Osorio J, Crous C, de Beer Z, Wingfield M, Roux J. Endophytic Botryosphaeriaceae, including five new species, associated with mangrove trees in South Africa. Fungal Biol. 2017;121:361-393 pubmed publisher
    ..The inoculation studies revealed that one of the new species, Lasiodiplodia avicenniae is highly pathogenic to A. marina and could pose a threat to the health of these trees. ..
  61. Widjaja M, Harvey K, Hagemann L, Berry I, Jarocki V, Raymond B, et al. Elongation factor Tu is a multifunctional and processed moonlighting protein. Sci Rep. 2017;7:11227 pubmed publisher
    ..We show Elongation factor Tu (Ef-Tu) moonlights on the surface of the human pathogens Staphylococcus aureus (SaEf-Tu) and ..
  62. Seo J, Sun H, Park B, Huang C, Yeh S, Jung C, et al. ELF18-INDUCED LONG-NONCODING RNA Associates with Mediator to Enhance Expression of Innate Immune Response Genes in Arabidopsis. Plant Cell. 2017;29:1024-1038 pubmed publisher
    ..molecular patterns, including peptide fragment of bacterial flagellin (flg22) or translation elongation factor Tu (elf18)...
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  64. Gillardon F. Interaction of elongation factor 1-alpha with leucine-rich repeat kinase 2 impairs kinase activity and microtubule bundling in vitro. Neuroscience. 2009;163:533-9 pubmed publisher
    ..Here we show that human LRRK2 co-purifies/co-immunoprecipitates with elongation factor 1-alpha (EF1A)...
  65. Parissi V, Calmels C, de Soultrait V, Caumont A, Fournier M, Chaignepain S, et al. Functional interactions of human immunodeficiency virus type 1 integrase with human and yeast HSP60. J Virol. 2001;75:11344-53 pubmed
    ..In addition, the functional human HSP60-HSP10 complex in the presence of ATP was able to recognize the HIV-1 IN as a substrate. ..
  66. Pöting A, Danker K, Hartmann L, Koster M, Wedlich D, Knochel W. Two different mRNAs coding for identical elongation factor 1 alpha (EF-1 alpha) polypeptides in Xenopus laevis embryos. Differentiation. 1990;44:103-10 pubmed
    ..A high amount of EF-1 alpha mRNA was detected in previtellogenic oocytes. At later stages of embryonic development, EF-1 alpha mRNA was found to be accumulated in translationally active tissues...
  67. Wilker E, van Vugt M, Artim S, Huang P, Petersen C, Reinhardt H, et al. 14-3-3sigma controls mitotic translation to facilitate cytokinesis. Nature. 2007;446:329-32 pubmed
  68. Huang Y, Hu J, Qi Y, Wu Y, Zheng J, Chen Y, et al. [Effect of knocking down eEF1A1 gene on proliferation and apoptosis in Jurkat cells and its mechanisms]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2012;20:835-41 pubmed
    This study was purposed to investigate the effect of knocking down eukaryotic elongation factor 1A1 (eEF1A1) gene on the proliferation and apoptosis in human acute T lymphocytic leukemia (T-ALL) cell line Jurkat and explore its mechanism...
  69. Schulz I, Engel C, Niestroj A, Kehlen A, Rahfeld J, Kleinschmidt M, et al. A non-canonical function of eukaryotic elongation factor 1A1: regulation of interleukin-6 expression. Biochim Biophys Acta. 2014;1843:965-75 pubmed publisher
    ..surface plasmon resonance analyses and RNAi-mediated knock-down, the eukaryotic elongation factor 1A1 (eEF1A1) was verified as the relevant target of HAK bioactivity...
  70. Beckelman B, Zhou X, Keene C, Ma T. Impaired Eukaryotic Elongation Factor 1A Expression in Alzheimer's Disease. Neurodegener Dis. 2016;16:39-43 pubmed publisher
    ..Moreover, it has been established that eukaryotic elongation factor 1A (eEF1A) plays a critical role in maintaining long-term synaptic plasticity, a cellular model for learning and memory...
  71. Abbas W, Khan K, Kumar A, Tripathy M, Dichamp I, Keita M, et al. Blockade of BFA-mediated apoptosis in macrophages by the HIV-1 Nef protein. Cell Death Dis. 2014;5:e1080 pubmed publisher
    ..We assessed the role of Nef and of the translation elongation factor eEF1A in primary human macrophages...
  72. Chen Z, Ye J, Ashraf U, Li Y, Wei S, Wan S, et al. MicroRNA-33a-5p Modulates Japanese Encephalitis Virus Replication by Targeting Eukaryotic Translation Elongation Factor 1A1. J Virol. 2016;90:3722-34 pubmed publisher
    ..A dual-luciferase reporter assay identified eukaryotic translation elongation factor 1A1 (EEF1A1) as one of the miR-33a-5p target genes...
  73. Ahn S, Oh W, Kim B, Kang D, Kim M, Heo G, et al. Inhibitory effects of rosmarinic acid on Lck SH2 domain binding to a synthetic phosphopeptide. Planta Med. 2003;69:642-6 pubmed
  74. Watts C, Cooper S, Saint K. Review of Australian <i>Scirtes</i> Illiger, Ora Clark and <i>Exochomoscirtes</i> Pic Coleoptera: Scirtidae) including descriptions of new species, new groups and a multi-gene molecular phylogeny of Australian and non-Australi. Zootaxa. 2017;4347:511-532 pubmed publisher
    ..pinjarraensis Watts, 2006. Scirtes rutai nom. nov. is proposed as a replacement name for S. beccus Ruta, Kia?ka & Yoshitomi, 2014 from Sabah as it is preoccupied by S. beccus Watts, 2004 from Australia. ..
  75. Kielbassa K, Muller H, Meyer H, Marks F, Gschwendt M. Protein kinase C delta-specific phosphorylation of the elongation factor eEF-alpha and an eEF-1 alpha peptide at threonine 431. J Biol Chem. 1995;270:6156-62 pubmed
    ..Substitution of Arg-429 by alanine abolishes the ability of PKC delta to phosphorylate the peptide, and insertion of additional basic amino acids in the vicinity of Thr-431 causes a complete loss of selectivity. ..
  76. Chen S, Lu S, Liu L, Wang C, Yang X, Zhang Z, et al. eEF1A1 Overexpression Enhances Tumor Progression and Indicates Poor Prognosis in Hepatocellular Carcinoma. Transl Oncol. 2018;11:125-131 pubmed publisher
    ..The aberrant state of protein synthesis leads to tumor progression. Eukaryotic elongation factor 1 alpha 1 (eEF1A1) is a major member of the eukaryotic elongation factor family that regulates protein synthesis...
  77. Karmakar S, Mahajan M, Schulz V, Boyapaty G, Weissman S. A multiprotein complex necessary for both transcription and DNA replication at the ?-globin locus. EMBO J. 2010;29:3260-71 pubmed publisher
    ..These results imply a direct link between mammalian DNA replication, transcription and histone acetylation mediated by a single multiprotein complex. ..
  78. Yang H, Noel J, Whitford P. Anisotropic Fluctuations in the Ribosome Determine tRNA Kinetics. J Phys Chem B. 2017;121:10593-10601 pubmed publisher
    ..In addition, when elongation factor Tu (EF-Tu) is present, the A/T ensemble is further destabilized in an L11-dependent manner...
  79. Schnicker N, Razzaghi M, Guha Thakurta S, Chakravarthy S, Dey M. Bacillus anthracis Prolyl 4-Hydroxylase Interacts with and Modifies Elongation Factor Tu. Biochemistry. 2017;56:5771-5785 pubmed publisher
    ..P4Hs) homologous to the hypoxia-inducible factor (HIF) prolyl hydroxylase domain (PHD) enzymes that act on elongation factor Tu (EFTu) and are likely involved in the regulation of bacterial translation...
  80. Byun H, Han N, Lee H, Kim K, Ko Y, Yoon G, et al. Cathepsin D and eukaryotic translation elongation factor 1 as promising markers of cellular senescence. Cancer Res. 2009;69:4638-47 pubmed publisher
    ..The other elongation factor, eukaryotic translation elongation factor 1alpha1 (eEF1A1), was also down-regulated...
  81. Leclercq T, Moretti P, Pitson S. Guanine nucleotides regulate sphingosine kinase 1 activation by eukaryotic elongation factor 1A and provide a mechanism for eEF1A-associated oncogenesis. Oncogene. 2011;30:372-8 pubmed publisher
    ..We also examined a truncated isoform of eEF1A1, termed prostate tumour inducer-1 (PTI-1), which can induce neoplastic cell transformation through undefined ..
  82. Bec G, Kerjan P, Zha X, Waller J. Valyl-tRNA synthetase from rabbit liver. I. Purification as a heterotypic complex in association with elongation factor 1. J Biol Chem. 1989;264:21131-7 pubmed
    ..Wolfson, A., Orlovsky, A., and Gladilin, K. (1988) FEBS Lett. 238, 262-264), according to which the polypeptides other than that assigned to valyl-tRNA synthetase correspond to the subunits of Elongation Factor 1H. ..
  83. Aranda Orgilles B, Trockenbacher A, Winter J, Aigner J, Köhler A, Jastrzebska E, et al. The Opitz syndrome gene product MID1 assembles a microtubule-associated ribonucleoprotein complex. Hum Genet. 2008;123:163-76 pubmed publisher
    ..The dysfunction of this mechanism would lead to malfunction of microtubule-associated protein translation and to the development of OS. ..
  84. Sato A, Suematsu T, Aihara K, Kita K, Suzuki T, Watanabe K, et al. Duplication of Drosophila melanogaster mitochondrial EF-Tu: pre-adaptation to T-arm truncation and exclusion of bulky aminoacyl residues. Biochem J. 2017;474:957-969 pubmed publisher
    Translation elongation factor Tu (EF-Tu) delivers aminoacyl-tRNA (aa-tRNA) to ribosomes in protein synthesis. EF-Tu generally recognizes aminoacyl moieties and acceptor- and T-stems of aa-tRNAs...
  85. Chang J, Seok H, Kwon T, Min D, Ahn B, Lee Y, et al. Interaction of elongation factor-1alpha and pleckstrin homology domain of phospholipase C-gamma 1 with activating its activity. J Biol Chem. 2002;277:19697-702 pubmed
    ..Taken together, our data show that EF-1alpha plays a direct role in phosphoinositide metabolism of cellular signaling by regulating PLC-gamma1 activity via a split PH domain. ..
  86. Zhang Y, Zhang H, Hou P, Liang X, Li Z, Wang H. The novel gene AngRem104 downregulates glucocorticoid receptor expression and activates NF-kappaB in human mesangial cells. Biochem Biophys Res Commun. 2008;369:1057-60 pubmed publisher
    ..These results indicate that the novel gene AngRem104 is involved in the in vivo regulation of GR expression and the activation of NF-kappaB through interaction with GR-EF in human MCs. ..
  87. Michalska K, Gucinski G, Garza Sánchez F, Johnson P, Stols L, Eschenfeldt W, et al. Structure of a novel antibacterial toxin that exploits elongation factor Tu to cleave specific transfer RNAs. Nucleic Acids Res. 2017;45:10306-10320 pubmed publisher
    ..of the CDI toxin from Escherichia coli NC101 in ternary complex with its cognate immunity protein and elongation factor Tu (EF-Tu)...
  88. Scaggiante B, Bonin S, Cristiano L, Siracusano S, Stanta G, Dapas B, et al. Prostate-tumor-inducing gene-1 analysis in human prostate cancer cells and tissue in relation to Mycoplasma infection. Cancer Invest. 2008;26:800-8 pubmed publisher
    ..The overall data indicate that, in prostate tumor cell lines, PTI-1 presence parallels Mycoplasma infection suggesting that PTI-1 might not necessarily play a major role in the onset of prostate tumorigenesis...
  89. Migliaccio N, Martucci N, Ruggiero I, Sanges C, Ohkubo S, Lamberti A, et al. Ser/Thr kinases and polyamines in the regulation of non-canonical functions of elongation factor 1A. Amino Acids. 2016;48:2339-52 pubmed publisher
    ..In this review, we focus on the different kinases that recognize the Ser and Thr residues of the eEF1A1 and eEF1A2 isoforms and regulate their involvement in different cellular processes like cell survival and ..
  90. Ann D, Wu M, Huang T, Carlson D, Wu R. Retinol-regulated gene expression in human tracheobronchial epithelial cells. Enhanced expression of elongation factor EF-1 alpha. J Biol Chem. 1988;263:3546-9 pubmed
    ..Results presented by these studies indicate that retinol may regulate the transcription of a factor required for translation. ..
  91. Perez J, Siegal G, Kriek J, Hård K, Dijk J, Canters G, et al. The solution structure of the guanine nucleotide exchange domain of human elongation factor 1beta reveals a striking resemblance to that of EF-Ts from Escherichia coli. Structure. 1999;7:217-26 pubmed
    ..In particular, Tyr181 of hEF-1beta[135-224] appears to be analogous to Phe81 of Escherichia coli EF-Ts. ..
  92. Lai J, Ghaemi Z, Luthey Schulten Z. The Conformational Change in Elongation Factor Tu Involves Separation of Its Domains. Biochemistry. 2017;56:5972-5979 pubmed publisher
    b>Elongation factor Tu (EF-Tu) is a highly conserved GTPase that is responsible for supplying the aminoacylated tRNA to the ribosome...