Gene Symbol: EDNRB
Description: endothelin receptor type B
Alias: ABCDS, ET-B, ET-BR, ETB, ETB1, ETBR, ETRB, HSCR, HSCR2, WS4A, endothelin receptor type B, endothelin receptor non-selective type, endothelin receptor subtype B1
Species: human
Products:     EDNRB

Top Publications

  1. Sánchez Mejías A, Fernández R, Lopez Alonso M, Antinolo G, Borrego S. New roles of EDNRB and EDN3 in the pathogenesis of Hirschsprung disease. Genet Med. 2010;12:39-43 pubmed publisher
    ..The aim of this study was to evaluate the implication of the EDN3 and EDNRB genes in a series of patients with Hirschsprung disease from Spain and determinate their mutational spectrum...
  2. Schussel J, Zhou X, Zhang Z, Pattani K, Bermudez F, Jean Charles G, et al. EDNRB and DCC salivary rinse hypermethylation has a similar performance as expert clinical examination in discrimination of oral cancer/dysplasia versus benign lesions. Clin Cancer Res. 2013;19:3268-75 pubmed publisher
    ..In a prospective study of a high-risk population, we showed that endothelin receptor type B (EDNRB) promoter methylation in salivary rinses is a useful biomarker for oral cancer and premalignancy...
  3. Ahnstedt H, Saveland H, Nilsson O, Edvinsson L. Human cerebrovascular contractile receptors are upregulated via a B-Raf/MEK/ERK-sensitive signaling pathway. BMC Neurosci. 2011;12:5 pubmed publisher
    ..Therefore, specific targeting of B-Raf might be a novel approach to reduce tissue damage after cerebral ischemia by preventing the previously observed upregulation of contractile receptors in smooth muscle cells. ..
  4. Cruz Munoz W, Jaramillo M, Man S, Xu P, Banville M, Collins C, et al. Roles for endothelin receptor B and BCL2A1 in spontaneous CNS metastasis of melanoma. Cancer Res. 2012;72:4909-19 pubmed publisher
    ..of spontaneous melanoma CNS metastasis, we have identified alterations in expression of endothelin receptor B (EDNRB) as a potential factor that influences brain metastatic potential...
  5. Puffenberger E, Hosoda K, Washington S, Nakao K, deWit D, Yanagisawa M, et al. A missense mutation of the endothelin-B receptor gene in multigenic Hirschsprung's disease. Cell. 1994;79:1257-66 pubmed
    ..We recently mapped a recessive susceptibility locus (HSCR2) to human chromosome 13q22, which we now demonstrate to be the endothelin-B receptor gene (EDNRB)...
  6. Tang W, Li B, Tang J, Liu K, Qin J, Wu W, et al. Methylation analysis of EDNRB in human colon tissues of Hirschsprung's disease. Pediatr Surg Int. 2013;29:683-8 pubmed publisher
    ..The endothelin receptor type B (EDNRB) gene has been localized to the chromosome 13q22 region and encodes a G-protein coupled receptor, ..
  7. Nilsson D, Gustafsson L, Wackenfors A, Gesslein B, Edvinsson L, Paulsson P, et al. Up-regulation of endothelin type B receptors in the human internal mammary artery in culture is dependent on protein kinase C and mitogen-activated kinase signaling pathways. BMC Cardiovasc Disord. 2008;8:21 pubmed publisher
    Up-regulation of vascular endothelin type B (ETB) receptors is implicated in the pathogenesis of cardiovascular disease...
  8. Tao K, Wu C, Wu K, Li W, Han G, Shuai X, et al. Quantitative analysis of promoter methylation of the EDNRB gene in gastric cancer. Med Oncol. 2012;29:107-12 pubmed publisher
    Hypermethylation has been shown in the promoter region of the endothelin receptor B (EDNRB) gene in several human tumors. However, its role in gastric cancer formation is still unclear...
  9. Wuttig D, Zastrow S, Fussel S, Toma M, Meinhardt M, Kalman K, et al. CD31, EDNRB and TSPAN7 are promising prognostic markers in clear-cell renal cell carcinoma revealed by genome-wide expression analyses of primary tumors and metastases. Int J Cancer. 2012;131:E693-704 pubmed publisher
    ..A prognostic impact was confirmed for the genes CD31, EDNRB and TSPAN7 at the mRNA level (n=86), and for TSPAN7 at the protein level (n=106)...

More Information

Publications103 found, 100 shown here

  1. Hsiao P, Liu M, Chen L, Tsai C, Wang Y, Chen J, et al. Promoter methylation of p16 and EDNRB gene in leukemia patients in Taiwan. Chin J Physiol. 2008;51:27-31 pubmed
    ..In this study, we have identified the methylation frequency of p16 and endothelin receptor type B (EDNRB) of 26 leukemia patients and 8 randomly selected normal blood donors in Taiwan...
  2. Zhao B, Sun D, Zhang M, Tan S, Ma X. Identification of aberrant promoter methylation of EDNRB gene in esophageal squamous cell carcinoma. Dis Esophagus. 2009;22:55-61 pubmed publisher
    ..we identified a frequently methylated fragment that showed a high homology to the 5' CpG island of endothelin receptor type B (EDNRB) gene...
  3. Wülfing P, Diallo R, Kersting C, Wulfing C, Poremba C, Rody A, et al. Expression of endothelin-1, endothelin-A, and endothelin-B receptor in human breast cancer and correlation with long-term follow-up. Clin Cancer Res. 2003;9:4125-31 pubmed
    ..Therefore, analysis of ET(A)R expression may improve the prediction of relapse and death and facilitate an individually based risk-directed adjuvant therapy in breast cancer patients. ..
  4. Jabeen R, Babar M, Ahmad J, Awan A. Novel mutations of endothelin-B receptor gene in Pakistani patients with Waardenburg syndrome. Mol Biol Rep. 2012;39:785-8 pubmed publisher
    Mutations in EDNRB gene have been reported to cause Waardenburg-Shah syndrome (WS4) in humans. We investigated 17 patients with WS4 for identification of mutations in EDNRB gene using PCR and direct sequencing technique...
  5. Wülfing P, Kersting C, Tio J, Fischer R, Wulfing C, Poremba C, et al. Endothelin-1-, endothelin-A-, and endothelin-B-receptor expression is correlated with vascular endothelial growth factor expression and angiogenesis in breast cancer. Clin Cancer Res. 2004;10:2393-400 pubmed
    ..Our findings provide evidence that the expression pattern of the ET-axis and in particular of ET(A)R may have clinical relevance in future antiangiogenic targeted therapies for breast cancer. ..
  6. Eltze E, Bertolin M, Korsching E, Wülfing P, Maggino T, Lelle R. Expression and prognostic relevance of endothelin-B receptor in vulvar cancer. Oncol Rep. 2007;18:305-11 pubmed
    Overexpression of endothelin (ET)-1 and its receptors, ETAR and ETBR, commonly referred to as the 'ET-axis', has been demonstrated to play a role in cancer progression for various human tumours...
  7. Wenner M, Taylor H, Stachenfeld N. Endothelin B receptor contribution to peripheral microvascular function in women with polycystic ovary syndrome. J Physiol. 2011;589:4671-9 pubmed publisher
    ..Our studies suggest that the lower ET-B receptor responsiveness associated with PCOS may reflect lower endothelial-mediated vasodilatation independent of generally lower vascular reactivity. ..
  8. Wackenfors A, Emilson M, Ingemansson R, Hortobagyi T, Szok D, Tajti J, et al. Ischemic heart disease induces upregulation of endothelin receptor mRNA in human coronary arteries. Eur J Pharmacol. 2004;484:103-9 pubmed
    ..The aims were to quantify endothelin type A (ETA) and type B (ETB) receptor mRNA levels in human coronary arteries from patients with ischemic heart disease, congestive heart ..
  9. Guruli G, Pflug B, Pecher S, Makarenkova V, Shurin M, Nelson J. Function and survival of dendritic cells depend on endothelin-1 and endothelin receptor autocrine loops. Blood. 2004;104:2107-15 pubmed
    ..The endothelin receptors, ETA and ETB, have differential tissue and functional distributions...
  10. Yasuda H, Kamide K, Takiuchi S, Matayoshi T, Hanada H, Kada A, et al. Association of single nucleotide polymorphisms in endothelin family genes with the progression of atherosclerosis in patients with essential hypertension. J Hum Hypertens. 2007;21:883-92 pubmed
    ..a potent vasoconstrictive peptide and its activity is mediated by the receptors ET type A (EDNRA) and ET type B (EDNRB)...
  11. Ling L, Kuc R, Maguire J, Davie N, Webb D, Gibbs P, et al. Comparison of endothelin receptors in normal versus cirrhotic human liver and in the liver from endothelial cell-specific ETB knockout mice. Life Sci. 2012;91:716-22 pubmed publisher
    ..These data support a role for the ET system in cirrhosis of the liver and suggest that endothelial ET(B) blockade may cause sinusoidal constriction which may contribute to hepatotoxicity associated with some endothelin antagonists. ..
  12. Anguelova E, Beuvon F, Leonard N, Chaverot N, Varlet P, Couraud P, et al. Functional endothelin ET B receptors are selectively expressed in human oligodendrogliomas. Brain Res Mol Brain Res. 2005;137:77-88 pubmed
    ..These data point to ET-1 as a possible survival factor for oligodendrogliomas via ET(B)-R activation and suggest that ET(B)-R-specific antagonists might constitute a potential therapeutic alternative for oligodendrogliomas. ..
  13. Shen C, Yang L, Yuan X. Endothelin B receptor expression in human astrocytoma: association with clinicopathological variables and survival outcomes. Int J Neurosci. 2011;121:626-31 pubmed publisher
    The endothelin (ET) axis has been implicated in astrocytoma growth and progression. Selective ETB receptor antagonists blocked proliferation and induced apoptosis in astrocytoma cell lines, suggesting that the ETB receptor could be a ..
  14. Arai H, Nakao K, Takaya K, Hosoda K, Ogawa Y, Nakanishi S, et al. The human endothelin-B receptor gene. Structural organization and chromosomal assignment. J Biol Chem. 1993;268:3463-70 pubmed
    ..The present study will lead to a better understanding of the mechanism for the transcriptional regulation of the hET-BR gene and will give a clue as to how to search for possible genetic disorders of hET-BR. ..
  15. Buckanovich R, Facciabene A, Kim S, Benencia F, Sasaroli D, Balint K, et al. Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy. Nat Med. 2008;14:28-36 pubmed
    ..These findings highlight a molecular mechanism with the potential to be pharmacologically manipulated to enhance the efficacy of tumor immunotherapy in humans. ..
  16. Zhang M, Song F, Liang L, Nan H, Zhang J, Liu H, et al. Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans. Hum Mol Genet. 2013;22:2948-59 pubmed publisher
    ..As a result, we identified a new region downstream of the EDNRB gene on 13q22 associated with hair color and the strongest association was the single-nucleotide polymorphism (SNP)..
  17. Chen L, Zhu J, Schumacher J, Wei C, Ramdas L, Prieto V, et al. SCF-KIT signaling induces endothelin-3 synthesis and secretion: Thereby activates and regulates endothelin-B-receptor for generating temporally- and spatially-precise nitric oxide to modulate SCF- and or KIT-expressing cell functions. PLoS ONE. 2017;12:e0184154 pubmed publisher
    ..2) SCF-KIT signaling induces timely local ET3 synthesis and secretion. (3) ET3 binds to ETBR on both sides of intercellular space...
  18. Jin C, Speed J, Pollock D. High salt intake increases endothelin B receptor function in the renal medulla of rats. Life Sci. 2016;159:144-147 pubmed publisher
    Endothelin (ET)-1 promotes natriuresis via the endothelin B receptor (ETB) within the renal medulla...
  19. Armando I, Asico L, Wang X, Jones J, Serrão M, Cuevas S, et al. Antihypertensive effect of etamicastat in dopamine D2 receptor-deficient mice. Hypertens Res. 2018;41:489-498 pubmed publisher
    ..been related, in part, to increased sympathetic activity, renal oxidative stress, and renal endothelin B receptor (ETBR) expression...
  20. Zhang Q, Wang S, Yu Y, Sun S, Zhang Y, Zhang Y, et al. Salvianolic Acid A, as a Novel ETA Receptor Antagonist, Shows Inhibitory Effects on Tumor in Vitro. Int J Mol Sci. 2016;17: pubmed publisher
    ..proliferation of tumor cells by activating its receptors, endothelin A receptor (ETAR) and endothelin B receptor (ETBR). Dysregulation of ETAR activation promotes tumor development and progression...
  21. Hammond T, McEllin B, Morton P, Raymond M, Dupree J, Gallo V. Endothelin-B Receptor Activation in Astrocytes Regulates the Rate of Oligodendrocyte Regeneration during Remyelination. Cell Rep. 2015;13:2090-7 pubmed publisher
    ..approaches and cell-specific endothelin receptor (EDNR) ablation, we show that ET-1 acts selectively through EDNRB on astrocytes--and not OPCs--to indirectly inhibit remyelination...
  22. Wang R, Zhang N, Wang R, Wang S, Wang N. Two skin cell lines from wild-type and albino Japanese flounder (Paralichthys olivaceus): establishment, characterization, virus susceptibility, efficient transfection, and application to albinism study. Fish Physiol Biochem. 2017;43:1477-1486 pubmed publisher
    ..cyclase type 5 (adcy5), microphthalmia-associated transcription factor (mitf), and endothelin B receptor (ednrb), were downregulated in JFSK_alb versus JFSK_wt cells...
  23. Joshi M, Oesterling B, Wu C, Gwizdz N, Pais G, Briyal S, et al. Evaluation of liposomal nanocarriers loaded with ETB receptor agonist, IRL-1620, using cell-based assays. Neuroscience. 2016;312:141-52 pubmed publisher
    ..The effects were found to be independent of the NGF levels. Finally the free IRL-1620 was found to cause neuronal outgrowth equivalent to the 75ng/ml NGF treatment. ..
  24. Shraga Levine Z, Sokolovsky M. Functional coupling of G proteins to endothelin receptors is ligand and receptor subtype specific. Cell Mol Neurobiol. 2000;20:305-17 pubmed
    ..The unstimulated ET(A)R coimmunoprecipitated with Gi3alpha, whereas the unstimulated ETBR was much less strongly coupled to Gi3alpha...
  25. Hoshi N, Sugino T, Suzuki T. Expression of endothelin system in neuroblastic tumors: close association of endothelin-1 and endothelin B receptor expression with differentiation of tumor cells. Med Mol Morphol. 2009;42:110-7 pubmed publisher
    ..In conclusion, ET-1 and ET-B are expressed with differentiation of neuroblastic tumors. ..
  26. Terada K, Horinouchi T, Fujioka Y, Higashi T, Nepal P, Horiguchi M, et al. Agonist-promoted ubiquitination differentially regulates receptor trafficking of endothelin type A and type B receptors. J Biol Chem. 2014;289:35283-95 pubmed publisher
    Two types of G protein-coupled receptors for endothelin-1 (ET-1), ET type A receptor (ETAR) and ETBR, closely resemble each other, but upon ET-1 stimulation, they follow totally different intracellular trafficking pathways; ETAR is ..
  27. Mikhail M, Vachon P, D Orléans Juste P, Jacques D, Bkaily G. Role of endothelin-1 and its receptors, ETA and ETB, in the survival of human vascular endothelial cells. Can J Physiol Pharmacol. 2017;95:1298-1305 pubmed publisher
    ..This study revealed a new role for ETBR in the survival of hVECs. ..
  28. Peña S, Sherman T, Brookes P, Nehrke K. The Mitochondrial Unfolded Protein Response Protects against Anoxia in Caenorhabditis elegans. PLoS ONE. 2016;11:e0159989 pubmed publisher
    ..the UPRmt's role in adaption, we found that either its pharmacological or genetic activation by ethidium bromide (EtBr) or RNAi of the mitochondrial AAA-protease spg-7 was sufficient to reduce death in an anoxia-based Caenorhabditis ..
  29. Thaker A, Kapur R. Colonic Adventitial Fibromuscular Dysplasia: A Nonspecific Arteriopathy Associated With Hirschsprung Disease and Other Obstructive Disorders. Pediatr Dev Pathol. 2017;:1093526617739772 pubmed publisher
    ..dysplasia," AFD) was purported as specific to arteries in the transition zone of Hirschsprung disease (HSCR) patients...
  30. Mous D, Buscop van Kempen M, Wijnen R, Tibboel D, Rottier R. Changes in vasoactive pathways in congenital diaphragmatic hernia associated pulmonary hypertension explain unresponsiveness to pharmacotherapy. Respir Res. 2017;18:187 pubmed publisher
    ..CDH lungs showed increased expression of both ETA and ETB endothelin receptors and the rate-limiting Endothelin Converting Enzyme (ECE-1), and a decreased expression of the ..
  31. He S, Park Y, Yorio T, Krishnamoorthy R. Endothelin-Mediated Changes in Gene Expression in Isolated Purified Rat Retinal Ganglion Cells. Invest Ophthalmol Vis Sci. 2015;56:6144-61 pubmed publisher
    ..A growing body of evidence suggests that the vasoactive peptides endothelins (ETs) and their receptors (primarily the ETB receptor) are contributors to neurodegeneration in glaucoma...
  32. Yaiw K, Mohammad A, Costa H, Taher C, Badrnya S, Assinger A, et al. Human Cytomegalovirus Up-Regulates Endothelin Receptor Type B: Implication for Vasculopathies?. Open Forum Infect Dis. 2015;2:ofv155 pubmed publisher
    Background.  Both endothelin receptor type B ([ETBR], a G protein-coupled receptor that mediates the vascular effects of the potent vasoconstrictor endothelin-1) and human cytomegalovirus ([HCMV], a ubiquitous herpesvirus) have been ..
  33. Shin J, Kim D, Seo J, Oh J, Park K, Kim H, et al. Potential association of VAMP5 polymorphisms with total colonic aganglionosis in Hirschsprung disease. Neurogastroenterol Motil. 2016;28:1055-63 pubmed publisher
    Hirschsprung disease (HSCR) is a congenital bowel disease caused by the absence of nerve cells in portions of the intestine...
  34. Kern C, Liao L. A post-decoding re-ranking algorithm for predicting interacting residues in proteins with hidden Markov models incorporating long-distance information. Comput Biol Chem. 2016;65:21-28 pubmed publisher
    ..of such correlations in the interaction profile hidden Markov models with a special decoding algorithm (ETB-Viterbi) has led to improvement in prediction accuracy...
  35. Soldano S, Pizzorni C, Paolino S, Trombetta A, Montagna P, Brizzolara R, et al. Alternatively Activated (M2) Macrophage Phenotype Is Inducible by Endothelin-1 in Cultured Human Macrophages. PLoS ONE. 2016;11:e0166433 pubmed publisher
    ..in the fibrotic process, exerting its pro-fibrotic effects through the interaction with its receptors (ETA and ETB)...
  36. Morimoto N, Mutai H, Namba K, Kaneko H, Kosaki R, Matsunaga T. Homozygous EDNRB mutation in a patient with Waardenburg syndrome type 1. Auris Nasus Larynx. 2018;45:222-226 pubmed publisher
    ..R319W) in endothelin receptor type B (EDNRB) gene. The asymptomatic parents had the mutation in a heterozygote state...
  37. Stannard C, Lehenkari P, Godovac Zimmermann J. Functional diversity of endothelin pathways in human lung fibroblasts may be based on structural diversity of the endothelin receptors. Biochemistry. 2003;42:13909-18 pubmed
    ..Overall, the ETA receptor was modified at 20 sites (15 phosphorylation, five palmitoylation sites) and ETB at 17 sites (13 phosphorylation, four palmitoylation sites)...
  38. He S, Minton A, Ma H, Stankowska D, Sun X, Krishnamoorthy R. Involvement of AP-1 and C/EBP? in upregulation of endothelin B (ETB) receptor expression in a rodent model of glaucoma. PLoS ONE. 2013;8:e79183 pubmed publisher
    Previous studies showed that the endothelin B receptor (ETB) expression was upregulated and played a key role in neurodegeneration in rodent models of glaucoma...
  39. Abukar Y, May C, Ramchandra R. Role of endothelin-1 in mediating changes in cardiac sympathetic nerve activity in heart failure. Am J Physiol Regul Integr Comp Physiol. 2016;310:R94-9 pubmed publisher
    ..The effects of intravenous tezosentan (a nonselective ETA and ETB receptor antagonist) (8 mg·kg(-1)·h(-1)) on resting levels of CSNA, arterial pressure, and heart rate were ..
  40. Ho U, Chen C, Lin C, Hsu Y, Chi F, Chou C, et al. Application of ultrasound-guided core biopsy to minimize the non-diagnostic results and the requirement of diagnostic surgery in extrapulmonary tuberculosis of the head and neck. Eur Radiol. 2016;26:2999-3005 pubmed publisher
    Head and neck extrapulmonary tuberculosis (ETB) presenting as lymphadenopathy poses a great threat by potentially increasing the deterioration of clinical outcomes...
  41. Southwood M, Mackenzie Ross R, Kuc R, Hagan G, Sheares K, Jenkins D, et al. Endothelin ETA receptors predominate in chronic thromboembolic pulmonary hypertension. Life Sci. 2016;159:104-110 pubmed publisher
    ..tissue cross-sections were analysed using autoradiography with [(125)I]-ET-1 using ligands selective for ETA or ETB to determine sub-type distribution...
  42. Sharma A, Sharma R, Bhattacharyya T, Bhando T, Pathania R. Fosfomycin resistance in Acinetobacter baumannii is mediated by efflux through a major facilitator superfamily (MFS) transporter-AbaF. J Antimicrob Chemother. 2017;72:68-74 pubmed
    ..Drug susceptibility, accumulation and efflux of ethidium bromide (EtBr) were determined in this strain. abaF was disrupted in A...
  43. O Donnell A, Coyle D, Puri P. Decreased expression of Kv7 channels in Hirchsprung's disease. J Pediatr Surg. 2017;52:1177-1181 pubmed publisher
    ..the hypothesis that Kv7 channels are present in the normal human colon and are reduced in Hirschprung's disease (HSCR)...
  44. Botka T, Růžičková V, Svobodová K, Pantůček R, Petráš P, Čejková D, et al. Two highly divergent lineages of exfoliative toxin B-encoding plasmids revealed in impetigo strains of Staphylococcus aureus. Int J Med Microbiol. 2017;307:291-296 pubmed publisher
    Exfoliative toxin B (ETB) encoded by some large plasmids plays a crucial role in epidermolytic diseases caused by Staphylococcus aureus...
  45. Sun Y, Zhang X, Chen Z, Xu M, Ou M. Reduction of Uterine Perfusion Pressure Induced Redistribution of Endothelin Receptor Type-B Between the Intima and Media Contributes to the Pathogenesis of Pregnancy-Induced Hypertension. Cell Physiol Biochem. 2017;44:1715-1725 pubmed publisher
    ..To test whether the distribution of endothelin receptor type-A (ETAR) and type-B (ETBR) plays an important role in PIH, a reduction of uterine perfusion pressure (RUPP) rat model was used to mimic some ..
  46. Aly D, Salem S, Abdel Hamid M, Youssef N, El Shaer M. Endothelin-1 and its A and B receptors: are they possibly involved in vitiligo?. Acta Dermatovenerol Croat. 2013;21:12-8 pubmed
    ..The endothelin 1-axis [ET-1, endothelin A receptor (ETAR) and endothelin B receptor (ETBR)] is thought to play a role in the depigmentation process occurring in vitiligo, with no studies on the cutaneous ..
  47. Xie H, Zhu D, Xu C, Zhu H, Chen P, Li H, et al. Long none coding RNA HOTTIP/HOXA13 act as synergistic role by decreasing cell migration and proliferation in Hirschsprung disease. Biochem Biophys Res Commun. 2015;463:569-74 pubmed publisher
    ..However, whether they are associated with Hirschsprung disease (HSCR) progression remains unclear...
  48. Thengchaisri N, Hein T, Ren Y, Kuo L. Endothelin-1 impairs coronary arteriolar dilation: Role of p38 kinase-mediated superoxide production from NADPH oxidase. J Mol Cell Cardiol. 2015;86:75-84 pubmed publisher
    ..However, ETB receptor antagonist BQ788, H2O2 scavenger catalase, scrambled gp91 ds-tat, or inhibitors of xanthine oxidase (..
  49. Stobdan T, Zhou D, Ao Ieong E, Ortiz D, Ronen R, Hartley I, et al. Endothelin receptor B, a candidate gene from human studies at high altitude, improves cardiac tolerance to hypoxia in genetically engineered heterozygote mice. Proc Natl Acad Sci U S A. 2015;112:10425-30 pubmed publisher
    ..Using whole-genome sequencing, we discovered that EDNRB (Endothelin receptor type B) is a candidate gene involved in HA adaptation...
  50. Singh P, Gupta S, Sharma B. Antagonism of Endothelin (ETA and ETB) Receptors During Renovascular Hypertension-Induced Vascular Dementia Improves Cognition. Curr Neurovasc Res. 2016;13:219-29 pubmed
    ..It may be concluded that ET-1 antagonism may be regarded as possible agents for managing renovascular hypertension induced VaD. ..
  51. Cao L, Ping N, Cao Y, Li W, Cai Y, Warfvinge K, et al. The effects of MEK1/2 inhibition on cigarette smoke exposure-induced ET receptor upregulation in rat cerebral arteries. Toxicol Appl Pharmacol. 2016;304:70-8 pubmed publisher
    ..In contrast, ETB receptor was noted in endothelial cells...
  52. Ma J, Zhang T, Lin K, Sun H, Jiang H, Yang Y, et al. Waardenburg syndrome type II in a Chinese patient caused by a novel nonsense mutation in the SOX10 gene. Int J Pediatr Otorhinolaryngol. 2016;85:56-61 pubmed publisher
    ..with highly genetic heterogeneity and proved to be related by 6 genes as follows: PAX3, MITF, SNAI2, EDN3, EDNRB and SOX10. This article aims to identify the genetic causes of a Chinese WS child patient...
  53. Cartes C, Isla A, Lagos F, Castro D, Munoz M, Yanez A, et al. Search and analysis of genes involved in antibiotic resistance in Chilean strains of Piscirickettsia salmonis. J Fish Dis. 2017;40:1025-1039 pubmed publisher
    ..Our results were corroborated with EtBr permeability analysis, which revealed that the LF-89 strain accumulates this compound and has a reduced capacity to ..
  54. García Gómez E, Jaso Vera M, Juárez Verdayes M, Alcántar Curiel M, Zenteno J, Betanzos Cabrera G, et al. The 95?G mutation in the 5'untranslated region of the norA gene increases efflux activity in Staphylococcus epidermidis isolates. Microb Pathog. 2017;103:139-148 pubmed publisher
    ..epidermidis clinical isolates. The selection of isolates with HEA was performed based on ethidium bromide (EtBr) MIC values and efflux efficiency (EF) using the semi-automated fluorometric method...
  55. Das A, Majumder D, Saha C. Correlation of binding efficacies of DNA to flavonoids and their induced cellular damage. J Photochem Photobiol B. 2017;170:256-262 pubmed publisher
    ..CD spectra and EtBr displacement studies evidence myricetin and apigenin to be stronger intercalators of DNA compared to quercetin...
  56. Li H, Fan L, Zhu S, Shin M, Lu F, Qu J, et al. Epilation induces hair and skin pigmentation through an EDN3/EDNRB-dependent regenerative response of melanocyte stem cells. Sci Rep. 2017;7:7272 pubmed publisher
    ..Genetic and pharmacological disruption of the EDN3 receptor EDNRB in vivo significantly blocks the effect of epilation on follicular and epidermal melanocyte regeneration as well ..
  57. Yim J, Cho H, Rabkin S. Gene expression and gene associations during the development of heart failure with preserved ejection fraction in the Dahl salt sensitive model of hypertension. Clin Exp Hypertens. 2017;:1-12 pubmed publisher
    ..tissue growth factor (CTGF), endothelin-1 (ET-1), cytochrome B-245, alpha polypeptide (p22phox), endothelin receptor type B (ETB/EDNRB), brain natriuretic peptide (BNP), endothelin receptor type A (ETA/EDNRA), matrix ..
  58. Amiel J, Attie T, Jan D, Pelet A, Edery P, Bidaud C, et al. Heterozygous endothelin receptor B (EDNRB) mutations in isolated Hirschsprung disease. Hum Mol Genet. 1996;5:355-7 pubmed
    ..genes have been recently identified in HSCR, namely the RET proto-oncogene and the endothelin B receptor (EDNRB) gene...
  59. Tual Chalot S, Gagnadoux F, Trzepizur W, Priou P, Andriantsitohaina R, Martinez M. Circulating microparticles from obstructive sleep apnea syndrome patients induce endothelin-mediated angiogenesis. Biochim Biophys Acta. 2014;1842:202-7 pubmed publisher
    ..We highlight that circulating microparticles from OSAS patients can modify the secretome of endothelial cells leading to angiogenesis. ..
  60. Kobayashi Y, Yoshimoto Y, Yamamoto Y, Kimura K, Okuda K. Roles of EDNs in regulating oviductal NO synthesis and smooth muscle motility in cows. Reproduction. 2016;151:615-22 pubmed publisher
    ..Quantification of mRNA expressions indicated that expression of EDN receptor B (EDNRB) in the ampullary region was higher after ovulation than before ovulation, whereas expression of EDNRA in the ..
  61. Azad P, Stobdan T, Zhou D, Hartley I, Akbari A, Bafna V, et al. High-altitude adaptation in humans: from genomics to integrative physiology. J Mol Med (Berl). 2017;95:1269-1282 pubmed publisher
    ..We discuss two such examples: EDNRB and SENP1 and their role in cardiac tolerance and in the polycythemic response, respectively.
  62. Lin Y, Zhao Y, Liu E. High glucose upregulates endothelin type B receptors in vascular smooth muscle cells via the downregulation of Sirt1. Int J Mol Med. 2018;41:439-445 pubmed publisher
    ..Vascular smooth muscle endothelin type B (ETB) receptors are involved in the pathogenesis of CVDs and diabetes...
  63. Grossmann S, Higashiyama S, Oksche A, Schaefer M, Tannert A. Localisation of endothelin B receptor variants to plasma membrane microdomains and its effects on downstream signalling. Mol Membr Biol. 2009;26:279-92 pubmed publisher
    ..The data further suggest that caveolar enrichment of ET(B) receptors does not facilitate the release of EGF receptor ligands. However, independent of their localisation, ET(B) receptors are able to induce an ERK1/2 phosphorylation. ..
  64. Broască V, Ciobotaru C, Dimofte I, Aşchie M, Pruna A, Severin B. The correlation of genetic markers with anatomoclinical and histopathological forms in Hirschsprung's disease. Rom J Morphol Embryol. 2010;51:283-8 pubmed
    ..The molecular markers investigated by us are represented by: RET, EDNRB and EDN3...
  65. Kuc R, Carlebur M, Maguire J, Yang P, Long L, Toshner M, et al. Modulation of endothelin receptors in the failing right ventricle of the heart and vasculature of the lung in human pulmonary arterial hypertension. Life Sci. 2014;118:391-6 pubmed publisher
    ..The aim was to quantify the density of ETA and ETB receptors in cardiopulmonary tissue from PAH patients and the monocrotaline (MCT) rat, which recapitulates some of ..
  66. Otręba M, Miliński M, Buszman E, Wrześniok D, Beberok A. [Hereditary hypomelanocytoses: the role of PAX3, SOX10, MITF, SNAI2, KIT, EDN3 and EDNRB genes]. Postepy Hig Med Dosw (Online). 2013;67:1109-18 pubmed
    ..example, mutations of MITF, SNAI2 and SOX10 genes are observed in Waardenburg syndrome type II and mutations of EDNRB, EDN3 and SOX10 genes are responsible for Waardenburg syndrome type IV...
  67. Demokan S, Chang X, Chuang A, Mydlarz W, Kaur J, Huang P, et al. KIF1A and EDNRB are differentially methylated in primary HNSCC and salivary rinses. Int J Cancer. 2010;127:2351-9 pubmed publisher
    ..to evaluate to the utility of aberrant promoter hypermethylation for detection in a panel of 10 genes (KIF1A, EDNRB, CDH4, TERT, CD44, NISCH, PAK3, VGF, MAL and FKBP4) in head and neck squamous cell carcinoma (HNSCC) via a ..
  68. Barr T, Kornberg D, Montmayeur J, Long M, Reichheld S, Strichartz G. Validation of endothelin B receptor antibodies reveals two distinct receptor-related bands on Western blot. Anal Biochem. 2015;468:28-33 pubmed publisher
    ..respectively) and the second or third intracellular loop (IL2 or IL3, respectively) of the endothelin B receptor (ETB)...
  69. Shakir M, Hanif S, Alam M, Farhan M, Younus H. Hybrid pharmacophore approach for bio-relevant di-imines based homobimetallic complexes incorporating functionalized dicarboxylates as co-ligands: Synthesis, spectral and structural activity dependent biological insights (in-vitro DNA and HSA binding. J Photochem Photobiol B. 2017;174:106-125 pubmed publisher
    ..binding mode of complexes is further supported by competitive displacement assay by using fluorogenic dyes (EtBr and Hoechst 33258)...
  70. Higa T, Horinouchi T, Aoyagi H, Asano H, Nishiya T, Nishimoto A, et al. Endothelin type B receptor-induced sustained Ca2+ influx involves G(q/11)/phospholipase C-independent, p38 mitogen-activated protein kinase-dependent activation of Na+/H+ exchanger. J Pharmacol Sci. 2010;113:276-80 pubmed
    ..These results suggest that G(q/11)/PLC-independent NHE activation via p38MAPK plays an important role in ET(B)R- mediated sustained Ca2+ influx. ..
  71. Ishida H, Kogaki S, Ichimori H, Narita J, Nawa N, Ueno T, et al. Overexpression of endothelin-1 and endothelin receptors in the pulmonary arteries of failed Fontan patients. Int J Cardiol. 2012;159:34-9 pubmed publisher
    ..This study suggests a histopathological rationale for the potential benefits of endothelin receptor antagonists in patients with failing Fontan circulation. ..
  72. Löf Granström A, Wester T. Mortality in Swedish patients with Hirschsprung disease. Pediatr Surg Int. 2017;33:1177-1181 pubmed publisher
    Hirschsprung disease (HSCR) has previously been associated with increased mortality. The aim of this study was to assess mortality in patients with Hirschsprung disease in a population-based cohort...
  73. Gyftopoulos K, Chondrogianni C, Papadaki H. Increased expression of endothelin-1 and its receptors in varicocele: an immunohistochemical study. Fertil Steril. 2011;95:2554-6.e1-2 pubmed publisher
    ..However, immunohistochemical evaluation of spermatic and control vein samples from 55 patients with varicocele showed overexpression of ET-1 and its receptors ETA and ETB in varicose veins.
  74. Kim J, Ahn J. Characterization of Clinically Isolated Antibiotic-Resistant Salmonella Typhimurium Exposed to Subinhibitory Concentrations of Ceftriaxone and Ciprofloxacin. Microb Drug Resist. 2017;23:949-957 pubmed publisher
    ..Typhimurium ATCC 19585. Compared to S. Typhimurium CCARM 8009, the ethidium bromide (EtBr) accumulation was considerably increased in S. Typhimurium ATCC 19585 when treated with efflux pump inhibitors. S...
  75. Nakamura H, Lim T, Puri P. Inflammatory bowel disease in patients with Hirschsprung's disease: a systematic review and meta-analysis. Pediatr Surg Int. 2018;34:149-154 pubmed publisher
    ..enterocolitis (HAEC) continues to be an important cause of morbidity in patients with Hirschsprung's disease (HSCR). HAEC can occur at any time during the course of the disease...
  76. Zhang L, Sui R. Effect of SNP polymorphisms of EDN1, EDNRA, and EDNRB gene on ischemic stroke. Cell Biochem Biophys. 2014;70:233-9 pubmed publisher
    ..to investigate the association between SNP polymorphisms of endothelin-1 (EDN1) and endothelin receptor (EDNRA and EDNRB) gene and ischemic stroke (IS) in the Chinese Han population in northern. A case-control study was introduced...
  77. Wiltz J, Blanck H, Lee B, Kocot S, Seeff L, McGuire L, et al. Electronic Information Standards to Support Obesity Prevention and Bridge Services Across Systems, 2010-2015. Prev Chronic Dis. 2017;14:E103 pubmed publisher
    ..The standards capture healthy weight data on the "ABCDs" of a visit to a health care provider that addresses initial obesity prevention and care: assessment, behaviors, ..
  78. Chen S, Lin C, Chen Y, Fang H, Cheng C, Chang C, et al. Aberrant promoter methylation of EDNRB in lung cancer in Taiwan. Oncol Rep. 2006;15:167-72 pubmed
    Hypermethylation has been shown in the promoter region of the endothelin receptor B (EDNRB) gene in several human tumors, but its role in lung cancer formation is unclear...
  79. Blouquit Laye S, Regnier A, Beauchet A, Zimmermann U, Devillier P, Chinet T. Expression of endothelin receptor subtypes in bronchial tumors. Oncol Rep. 2010;23:457-63 pubmed
    ..The expression of the ET-1 receptors ETA (ET(A)R) and ETB (ET(B)R) was analyzed by immunohistochemistry in fragments of human lung carcinomas...
  80. Sallum C, Wilson J, Rupasinghe C, Berg E, Yu J, Green D, et al. Enhancing and limiting endothelin-1 signaling with a cell-penetrating peptide mimicking the third intracellular loop of the ETB receptor. Chem Biol Drug Des. 2012;80:374-81 pubmed publisher
    ..The effect of this peptide on ERK activation was determined in ETB receptor cDNA-transfected Chinese hamster ovary cells and in ETA- and ETB-expressing human pulmonary artery smooth ..
  81. Elshourbagy N, Adamou J, Gagnon A, Wu H, Pullen M, Nambi P. Molecular characterization of a novel human endothelin receptor splice variant. J Biol Chem. 1996;271:25300-7 pubmed
    Endothelin receptors are widely distributed throughout a number of tissues. A novel ETB receptor splice variant (ETB-SVR) was identified from a human placental cDNA library...
  82. Tsutsumi M, Liang G, Jones P. Novel endothelin B receptor transcripts with the potential of generating a new receptor. Gene. 1999;228:43-9 pubmed
    ..rapid amplification of 5' cDNA ends (5' RACE), we have cloned three previously unrecognized endothelin B receptor (EDNRB) transcripts from a human melanoma cell line...
  83. Parahita I, Makhmudi A, Gunadi -. Comparison of Hirschsprung-associated enterocolitis following Soave and Duhamel procedures. J Pediatr Surg. 2018;53:1351-1354 pubmed publisher
    ..enterocolitis (HAEC) represents the primary cause of high morbidity and mortality in Hirschsprung disease (HSCR) patients. The most common surgical methods for HSCR are the Soave and Duhamel procedures...
  84. Frykman P, Kim S, Wester T, Nordenskjold A, KAWAGUCHI A, Hui T, et al. Critical evaluation of the Hirschsprung-associated enterocolitis (HAEC) score: A multicenter study of 116 children with Hirschsprung disease. J Pediatr Surg. 2018;53:708-717 pubmed publisher
    ..clinical criteria to diagnose Hirschsprung-associated enterocolitis (HAEC) in children with Hirschsprung disease (HSCR)...
  85. Cyr C, Huebner K, Druck T, Kris R. Cloning and chromosomal localization of a human endothelin ETA receptor. Biochem Biophys Res Commun. 1991;181:184-90 pubmed
    ..The human endothelin ETA receptor gene was localized to chromosome 4 by analysis of its segregation pattern in rodent-human hybrids. ..
  86. Carrasquillo M, McCallion A, Puffenberger E, Kashuk C, Nouri N, Chakravarti A. Genome-wide association study and mouse model identify interaction between RET and EDNRB pathways in Hirschsprung disease. Nat Genet. 2002;32:237-44 pubmed
    ..We identified susceptibility loci at 10q11, 13q22 and 16q23; the gene at 13q22 is EDNRB, encoding a G protein-coupled receptor (GPCR) and the gene at 10q11 is RET, encoding a receptor tyrosine kinase (..
  87. Dimitrijevic I, Edvinsson M, Chen Q, Malmsjo M, Kimblad P, Edvinsson L. Increased expression of vascular endothelin type B and angiotensin type 1 receptors in patients with ischemic heart disease. BMC Cardiovasc Disord. 2009;9:40 pubmed publisher
    ..Endothelin type A (ETA) and type B (ETB), and angiotensin type 1 (AT1) and type 2 (AT2) receptors expression and function were examined using ..
  88. Attie T, Till M, Pelet A, Amiel J, Edery P, Boutrand L, et al. Mutation of the endothelin-receptor B gene in Waardenburg-Hirschsprung disease. Hum Mol Genet. 1995;4:2407-9 pubmed
  89. Koehl B, Nivoit P, El Nemer W, Lenoir O, Hermand P, Pereira C, et al. The endothelin B receptor plays a crucial role in the adhesion of neutrophils to the endothelium in sickle cell disease. Haematologica. 2017;102:1161-1172 pubmed publisher
    ..Blockade of endothelin receptors, including ETB, may provide major benefits for preventing or treating vaso-occlusive crises in sickle cell patients. ..
  90. Han S, Yu H, Yang T, Wang S, Wang X. Magnetic Activated-ATP@Fe3O4 Nanocomposite as an Efficient Fenton-Like Heterogeneous Catalyst for Degradation of Ethidium Bromide. Sci Rep. 2017;7:6070 pubmed publisher
    ..ATP (A-ATP@Fe3O4) composites for catalytic degradation of ethidium bromide (EtBr, 80 mg/L) at different pH values, hydrogen peroxide (H2O2) concentrations, temperatures, ..
  91. Köchl R, Alken M, Rutz C, Krause G, Oksche A, Rosenthal W, et al. The signal peptide of the G protein-coupled human endothelin B receptor is necessary for translocation of the N-terminal tail across the endoplasmic reticulum membrane. J Biol Chem. 2002;277:16131-8 pubmed
    ..We postulate that signal peptides are necessary for those G protein-coupled receptors for which post-translational translocation of the N terminus is impaired or blocked by the presence of stably folded domains. ..
  92. Goddard J, Johnston N, Cumming A, Webb D. Fractional urinary excretion of endothelin-1 is reduced by acute ETB receptor blockade. Am J Physiol Renal Physiol. 2007;293:F1433-8 pubmed
    ..The influence of ET receptors on urinary ET-1 excretion has not been studied in humans, yet peritubular ETB receptors are abundant within the kidney...