EDARADD

Summary

Gene Symbol: EDARADD
Description: EDAR-associated death domain
Alias: ECTD11A, ECTD11B, ED3, EDA3, EDAR-associated death domain protein, crinkled homolog, ectodysplasia A receptor associated death domain, ectodysplasin A receptor associated adapter protein, ectodysplasin-A receptor-associated adapter protein
Species: human

Top Publications

  1. doi Highly specific detection of antibodies to tick-borne encephalitis (TBE) virus in humans using a domain III antigen and a sensitive immune complex (IC) ELISA
    Diana Ludolfs
    Department of Virology, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Str 74, 20356 Hamburg, Germany
    J Clin Virol 45:125-8. 2009
  2. ncbi The NF-kappaB signalling pathway in human diseases: from incontinentia pigmenti to ectodermal dysplasias and immune-deficiency syndromes
    Asma Smahi
    Département de Génétique et Unité de Recherches sur les Handicaps Génétiques de l Enfant INSERM UR 393, Hopital Necker, 149 rue de Sevres, 75743 Paris Cedex 15, France
    Hum Mol Genet 11:2371-5. 2002
  3. ncbi Protective immunity of E. coli-synthesized NS1 protein of Japanese encephalitis virus
    Cheng Wen Lin
    Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 404, Taiwan, ROC
    Biotechnol Lett 30:205-14. 2008
  4. ncbi Interleukin-4 ameliorates crescentic glomerulonephritis in Wistar Kyoto rats
    H T Cook
    Department of Histopathology, Imperial College School of Medicine, Hammersmith Hospital, London, England, United Kingdom
    Kidney Int 55:1319-26. 1999
  5. doi Mutation screening of the Ectodysplasin-A receptor gene EDAR in hypohidrotic ectodermal dysplasia
    Annemarie H van der Hout
    Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    Eur J Hum Genet 16:673-9. 2008
  6. ncbi Cloning, expression, and mutagenesis of trypsin inhibitor ETIb from Erythrina variegata seeds
    Y Kouzuma
    Laboratory of Biochemistry, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    Biosci Biotechnol Biochem 61:1041-3. 1997
  7. ncbi Expression and function of sialoadhesin in rat alveolar macrophages
    K Frei
    Institute of Histology and Embryology, University of Vienna, Schwarzspanierstrasse 17, A 1090, Vienna, Austria
    Immunol Lett 71:167-70. 2000
  8. doi From ectodermal dysplasia to selective tooth agenesis
    Gabriele I Mues
    Department of Biomedical Sciences, Texas A and M Health Science Center, Baylor College of Dentistry, 3302 Gaston Avenue, Dallas, TX 75246, USA
    Am J Med Genet A 149:2037-41. 2009
  9. pmc A gene for autosomal dominant hypohidrotic ectodermal dysplasia (EDA3) maps to chromosome 2q11-q13
    L Ho
    Department of Medical Genetics, University of Wisconsin, Madison, WI 53706, USA
    Am J Hum Genet 62:1102-6. 1998
  10. ncbi Effects of lipopolysaccharide on the appearance of macrophage populations and fibrogenesis in cisplatin-induced rat renal injury
    Jyoji Yamate
    Laboratory of Veterinary Pathology, Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University, Gakuencho 1 1, Sakai, Osaka 599 8531, Japan
    Exp Toxicol Pathol 56:13-24. 2004

Research Grants

  1. Antiviral Agents directed at West Nile Virus
    STEVEN WHITTEN; Fiscal Year: 2004
  2. BLOOD PLATELET THROMBOXANE RECEPTORS
    GUY LEBRETON; Fiscal Year: 2007
  3. Myogenic Stem Cell Function in Aging Skeletal Muscle
    Zipora Yablonka Reuveni; Fiscal Year: 2006
  4. CORE--CHEMISTRY
    Donald Landry; Fiscal Year: 2007
  5. Satellite Cells and Skeletal Muscle Growth Dynamics
    Zipora Yablonka Reuveni; Fiscal Year: 2007
  6. Myogenic stem cells in extraocular muscles
    Zipora Yablonka Reuveni; Fiscal Year: 2009
  7. Myogenic Stem Cell Function in Aging Skeletal Muscle
    Zipora Yablonka Reuveni; Fiscal Year: 2010
  8. Myogenic stem cells in extraocular muscles
    Zipora Yablonka Reuveni; Fiscal Year: 2010
  9. Trends in food consumption patterns of Americans
    ASHIMA KANT; Fiscal Year: 2005
  10. Myogenic Stem Cell Function in Aging Skeletal Muscle
    Zipora Yablonka Reuveni; Fiscal Year: 2002

Scientific Experts

Detail Information

Publications98

  1. doi Highly specific detection of antibodies to tick-borne encephalitis (TBE) virus in humans using a domain III antigen and a sensitive immune complex (IC) ELISA
    Diana Ludolfs
    Department of Virology, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Str 74, 20356 Hamburg, Germany
    J Clin Virol 45:125-8. 2009
    In contrast to most antibodies directed to the envelope glycoprotein of flaviviruses, those to the domain III (ED3) show serotype-specific reactions.
  2. ncbi The NF-kappaB signalling pathway in human diseases: from incontinentia pigmenti to ectodermal dysplasias and immune-deficiency syndromes
    Asma Smahi
    Département de Génétique et Unité de Recherches sur les Handicaps Génétiques de l Enfant INSERM UR 393, Hopital Necker, 149 rue de Sevres, 75743 Paris Cedex 15, France
    Hum Mol Genet 11:2371-5. 2002
    ..involved in NF-kappaB activation: ectodysplasin (EDA1), EDA-receptor (EDAR) and EDAR-associated death domain (EDARADD)...
  3. ncbi Protective immunity of E. coli-synthesized NS1 protein of Japanese encephalitis virus
    Cheng Wen Lin
    Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 404, Taiwan, ROC
    Biotechnol Lett 30:205-14. 2008
    ..coli-synthesized NS1 protein with another protective immunogen, the envelope domain III (ED3). Pre-challenge, detectable titers of JEV-specific neutralizing antibody were detected in the immunized mice with E...
  4. ncbi Interleukin-4 ameliorates crescentic glomerulonephritis in Wistar Kyoto rats
    H T Cook
    Department of Histopathology, Imperial College School of Medicine, Hammersmith Hospital, London, England, United Kingdom
    Kidney Int 55:1319-26. 1999
    ..Interleukin-4 (IL-4) down-regulates many macrophage proinflammatory activities. We therefore studied the effect of IL-4 on glomerular injury in a model of crescentic glomerulonephritis in the Wistar Kyoto rat...
  5. doi Mutation screening of the Ectodysplasin-A receptor gene EDAR in hypohidrotic ectodermal dysplasia
    Annemarie H van der Hout
    Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    Eur J Hum Genet 16:673-9. 2008
    ..ectodysplasin A (ED1) gene or the autosomal ectodysplasin A-receptor (EDAR) and EDAR-associated death domain (EDARADD) genes. X-linked and autosomal forms are sometimes clinically indistinguishable...
  6. ncbi Cloning, expression, and mutagenesis of trypsin inhibitor ETIb from Erythrina variegata seeds
    Y Kouzuma
    Laboratory of Biochemistry, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    Biosci Biotechnol Biochem 61:1041-3. 1997
    ..the mature form of ETIb was introduced into an expression vector, pET-22b, and expressed in Escherichia coli BL21 (ED3) in a functional form...
  7. ncbi Expression and function of sialoadhesin in rat alveolar macrophages
    K Frei
    Institute of Histology and Embryology, University of Vienna, Schwarzspanierstrasse 17, A 1090, Vienna, Austria
    Immunol Lett 71:167-70. 2000
    ..demonstrated on murine and rat mφ in lymphatic organs and is recognised by the monoclonal antibody (mAb) ED3 in the rat...
  8. doi From ectodermal dysplasia to selective tooth agenesis
    Gabriele I Mues
    Department of Biomedical Sciences, Texas A and M Health Science Center, Baylor College of Dentistry, 3302 Gaston Avenue, Dallas, TX 75246, USA
    Am J Med Genet A 149:2037-41. 2009
    ..that phenotypically identical syndromes (HED) can be caused by mutations in different genes (EDA, EDAR, EDARADD), that mutations in the same gene (EDA) can lead to different phenotypes (HED and selective tooth agenesis) and ..
  9. pmc A gene for autosomal dominant hypohidrotic ectodermal dysplasia (EDA3) maps to chromosome 2q11-q13
    L Ho
    Department of Medical Genetics, University of Wisconsin, Madison, WI 53706, USA
    Am J Hum Genet 62:1102-6. 1998
    ..By genetic linkage analysis of a large ADHED kindred, we have mapped a gene for ADHED (EDA3) to the proximal long arm of chromosome 2 (q11-q13)...
  10. ncbi Effects of lipopolysaccharide on the appearance of macrophage populations and fibrogenesis in cisplatin-induced rat renal injury
    Jyoji Yamate
    Laboratory of Veterinary Pathology, Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University, Gakuencho 1 1, Sakai, Osaka 599 8531, Japan
    Exp Toxicol Pathol 56:13-24. 2004
    ..Cells immunoreactive for ED1 (for exudate macrophages), ED2 (for resident macrophages) and ED3 (for activated resident macrophages) showed the highest number on day 4 or day 7, and thereafter, the numbers were ..
  11. ncbi Autosomal dominant anhidrotic ectodermal dysplasias at the EDARADD locus
    E Bal
    INSERM U781 et Département de Génétique, Hopital Necker Enfants Malades, Paris, France
    Hum Mutat 28:703-9. 2007
    ..In addition, mutations in a recently identified gene, EDARADD, encoding EDAR-associated death domain (EDARADD) have been shown to cause autosomal recessive EDA...
  12. ncbi The ectodysplasin pathway in feather tract development
    Leslie Houghton
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Development 132:863-72. 2005
    ..pathway, comprising the ligand ectodysplasin, its receptor Edar and a dedicated death domain adaptor protein Edaradd, plays an important role in epidermal organ formation in mammals...
  13. ncbi Mapping of a ligand-binding site for the human thromboxane A2 receptor protein
    Joseph W Turek
    Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Biol Chem 277:16791-7. 2002
    ..that ligands interact with amino acids contained within the C-terminal portion of the third extracellular domain (ED3) of the receptor protein...
  14. pmc Structure of yellow fever virus envelope protein domain III
    David E Volk
    Departments of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555 1157, USA
    Virology 394:12-8. 2009
    ..Variations in the structure and surface chemistry of ED3 between flaviviruses affect neutralization sites and may affect host cell receptor interactions and play a role in ..
  15. ncbi Immunohistochemical characterization of macrophage and dendritic cell subpopulations of the spleen, thymus, tongue and heart in cyclophosphamide-induced immunosuppressed rat
    S Yoon
    Department of Anatomy, College of Medicine, Pusan National University, Pusan, South Korea
    Anat Histol Embryol 32:80-8. 2003
    ..After CY treatment, remarkably, ED1+, ED2+ and ED3+ macrophage subpopulations, in general exhibited signs of cellular activation such as an increase in number and ..
  16. pmc Involvement of the Edar signaling in the control of hair follicle involution (catagen)
    Michael Y Fessing
    Department of Dermatology, Boston University School of Medicine, 609 Albany St, Boston, MA 02118, USA
    Am J Pathol 169:2075-84. 2006
    ..Here, we show that during the murine hair cycle the expression of Eda A1, Edar, Edaradd, and TRAF6 transcripts are minimal in the resting phase and maximal during HF transition from active growth to ..
  17. ncbi Novel mutations in the EDAR gene in two Pakistani consanguineous families with autosomal recessive hypohidrotic ectodermal dysplasia
    M Naeem
    Department of Biological Sciences, Quaid i Azam University, Islamabad 45320, Pakistan
    Br J Dermatol 153:46-50. 2005
    ..There are X-linked, autosomal recessive and autosomal dominant forms of this disorder. Mutations in the EDA gene cause X-linked HED and mutations in either the EDAR or the EDARADD genes cause autosomal forms of HED.
  18. pmc Involvement of and Interaction between WNT10A and EDA Mutations in Tooth Agenesis Cases in the Chinese Population
    Huiying He
    Department of Prosthodontics, School and Hospital of Stomatology, Peking University, Beijing, China
    PLoS ONE 8:e80393. 2013
    ..Additionally, EDA, EDAR, and EDARADD encode signaling molecules in the Eda/Edar/NF-κB signaling pathways, we also checked EDAR and EDARADD in this ..
  19. doi Reasonable design of antibody mimetics for targeting glioma and small cell lung cancer
    Tao Jiang
    Department of Thoracic Surgery, Xi an Tangdu Hospital, Fourth Military Medical University, Xi an, China
    Eur J Cancer Prev 18:431-5. 2009
    ..fused, the mimetic with the first 388 amino acid residues of diphtheria toxin, Escherichia coli strain, BL21 (ED3), was used for expression of soluble immunotoxins DT-BT and DT-TB...
  20. ncbi The distribution of antigen in lymphoid tissues following its injection into the anterior chamber of the rat eye
    Serge Camelo
    School of Anatomy and Human Biology, University of Western Australia, Crawley, Perth, Australia
    J Immunol 172:5388-95. 2004
    ..In the spleen, Ag-bearing cells were CD1(+), CD11b(+), ED1(+), ED2(low), ED3(+), CD86(low), OX6(+), CD11c(-), ED5(-) and in the LNs were CD4(+), CD8(+), CD80(+), and OX41(+) suggesting these ..
  21. doi Thermodynamic stability of domain III from the envelope protein of flaviviruses and its improvement by molecular design
    Nora Zidane
    Unit of Molecular Prevention and Therapy of Human Diseases, Department of Infection and Epidemiology, Institut Pasteur, rue du Dr Roux, F 75015 Paris, France
    Protein Eng Des Sel 26:389-99. 2013
    ..Domain III (ED3) of the viral envelope protein interacts with cell receptors and contains epitopes recognized by virus neutralizing ..
  22. ncbi Molecular epidemiology of HIV-1 in Venezuela: high prevalence of HIV-1 subtype B and identification of a B/F recombinant infection
    Erika Castro
    Department of Immunology, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil
    J Acquir Immune Defic Syndr 32:338-44. 2003
    ..The discrimination capacity of HIV-1 subtypes using the primer set ED3/14-ED31/33 among the Caracas samples was found to be higher than for those from Margarita Island...
  23. pmc Multiple linear epitopes (B-cell, CTL and Th) of JEV expressed in recombinant MVA as multiple epitope vaccine induces a protective immune response
    Fengjuan Wang
    Key Laboratory of Animal Diseases Diagnosis and Immunology, Ministry of Agriculture, Nanjing Agricultural University, Nanjing, 210095, China
    Virol J 9:204. 2012
    ..were almost no difference of cytokines and neutralizing antibody titers among 107 TCID50 rMVA-mep, recombinant ED3 and inactivated JEV vaccine...
  24. doi A founder ectodysplasin A receptor (EDAR) mutation results in a high frequency of the autosomal recessive form of hypohidrotic ectodermal dysplasia in India
    M D Bashyam
    Centre for DNA Fingerprinting and Diagnostics, Hyderabad 500001, India
    Br J Dermatol 166:819-29. 2012
    ..A receptor (EDAR), encoding the EDA-A1 receptor and ectodysplasin A receptor-associated death domain (EDARADD), encoding an adaptor protein...
  25. pmc Candidate gene analysis of tooth agenesis identifies novel mutations in six genes and suggests significant role for WNT and EDA signaling and allele combinations
    Sirpa Arte
    Institute of Dentistry, University of Helsinki, Helsinki, Finland
    PLoS ONE 8:e73705. 2013
    ..Together with our previous reports, we have identified two mutations in MSX1, AXIN2 and EDARADD, five in PAX9, four in EDA and EDAR, and nine in WNT10A...
  26. doi Ectodysplasin/NF-κB signaling in embryonic mammary gland development
    Päivi H Lindfors
    Developmental Biology Program, Institute of Biotechnology, University of Helsinki, P O Box 56, 00014, Helsinki, Finland
    J Mammary Gland Biol Neoplasia 18:165-9. 2013
    ..Eda) signaling pathway consists of a TNF-like ligand Eda, its receptor Edar, and an adaptor protein Edaradd and its activation leads to NF-κB mediated transcription...
  27. doi Conservation of the DENV-2 type-specific and DEN complex-reactive antigenic sites among DENV-2 genotypes
    Trevor J Pitcher
    Center for Biodefense and Emerging Infectious Diseases, Sealy Center for Vaccine Development, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555 0436, USA
    Virology 422:386-92. 2012
    The envelope (E) protein is composed of three domains (ED1, ED2 and ED3) with ED3 targeted by the most potent neutralizing antibodies. DENV-2 strains can be divided into six genotypes...
  28. doi Mutations in WNT10A are present in more than half of isolated hypodontia cases
    Marie José van den Boogaard
    Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
    J Med Genet 49:327-31. 2012
    ..Mutations in MSX1, PAX9, AXIN2 and the ectodermal dysplasia genes EDA, EDAR and EDARADD have been detected in familial severe tooth agenesis...
  29. doi Functional studies for the TRAF6 mutation associated with hypohidrotic ectodermal dysplasia
    H Fujikawa
    Laboratory of Genetic Skin Diseases Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Br J Dermatol 168:629-33. 2013
    ..A de novo heterozygous mutation in the tumour necrosis factor receptor-associated factor 6 gene (TRAF6) was recently identified in a patient with HED, while functional consequences resulting from the mutation remained unknown...
  30. doi High resolution crystal structure of dengue-3 envelope protein domain III suggests possible molecular mechanisms for serospecific antibody recognition
    Montasir Elahi
    Department of Biotechnology and Life Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Koganei Shi, Tokyo, Japan
    Proteins 81:1090-5. 2013
    ..Here, we report a 1.7 Å crystal structure of a recombinant dengue-3 envelope protein domain III (ED3), which contains most of the putative epitopes...
  31. ncbi Rat bone marrow and monocyte cultures: influence of culture time and lymphokines on the expression of macrophage differentiation antigens
    J G Damoiseaux
    Department of Cell Biology, Medical Faculty, Vrije Universiteit, Amsterdam, The Netherlands
    J Leukoc Biol 46:246-53. 1989
    ..The expression of the ED3 antigen is highly inducible in bone marrow cultures...
  32. doi Phenotypic characterization of mononuclear inflammatory cells following equine hydroxyapatite/collagen block grafting in rats
    Asim Alsuwaiyan
    King Fahd Military Medical Complex, Dhahran, Saudi Arabia
    Biomed Mater 7:065005. 2012
    ..monocytic cells (ED1), resident mononuclear phagocytes (ED2), mononuclear phagocytes of lymphoid origin (ED3), expression of Ia antigen (OX6), T-cells (OX19), and B-cells (OX33)...
  33. pmc Cross-reactivities between human IgMs and the four serotypes of dengue virus as probed with artificial homodimers of domain-III from the envelope proteins
    Nora Zidane
    Unit of Molecular Prevention and Therapy of Human Diseases, Department of Infection and Epidemiology, Institut Pasteur, rue du Docteur Roux, F 75015 Paris, France
    BMC Infect Dis 13:302. 2013
    ..Subsequent infection by a different serotype is a risk factor for severe dengue. Domain III (ED3) of the viral envelope protein interacts with cell receptors and contains epitopes recognized by neutralizing ..
  34. doi Molecular aspects of hypohidrotic ectodermal dysplasia
    Marja L Mikkola
    Developmental Biology Program, Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Am J Med Genet A 149:2031-6. 2009
    ..It is caused by mutations in any of the three Eda pathway genes: ectodysplasin (Eda), Edar, and Edaradd which encode a ligand, a receptor, and an intracellular signal mediator of a single linear pathway, respectively...
  35. doi A compound heterozygous mutation in the EDAR gene in a Spanish family with autosomal recessive hypohidrotic ectodermal dysplasia
    M R Moya-Quiles
    Biochemistry and Clinical Genetic Centre, Virgen de la Arrixaca University Hospital, 30120, El Palmar, Murcia, Spain
    Arch Dermatol Res 302:307-10. 2010
    ..Autosomal forms result from mutations in either the EDAR or the EDARADD gene. The X-linked and autosomal forms are phenotypically indistinguishable...
  36. doi The effect of EDTA with and without ultrasonics on removal of the smear layer
    Hong Guan Kuah
    Department of Restorative Dentistry, National Dental Centre of Singapore, Singapore
    J Endod 35:393-6. 2009
    ..B (Na3) and C (Na3US), 1% sodium hypochlorite for 3 minutes without and with ultrasonics, respectively; groups D (ED3) and E (ED3US), 17% EDTA for 3 minutes without and with ultrasonics, respectively; and groups F (ED1) and G (ED1US),..
  37. doi Characterization of dengue complex-reactive epitopes on dengue 3 virus envelope protein domain III
    Kiyohiko Matsui
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Virology 384:16-20. 2009
    ..The DENV envelope (E) protein ectodomain can be divided into three structural domains designated ED1, ED2, and ED3. The ED3 contains the DENV type-specific and DENV complex-reactive (epitopes shared by DENV 1-4) antigenic sites...
  38. pmc Characterization of a dengue type-specific epitope on dengue 3 virus envelope protein domain III
    Kiyohiko Matsui
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555 0436, USA
    J Gen Virol 91:2249-53. 2010
    ..The DENV envelope (E) protein ectodomain can be divided into three structural domains designated ED1, ED2 and ED3. The ED3 domain contains DENV type-specific and DENV complex-reactive antigenic sites...
  39. doi Assessment of individual finger muscle activity in the extensor digitorum communis by surface EMG
    J N A L Leijnse
    Department of Mechanical Engineering, Speed School of Engineering, University of Louisville, Louisville, KY 40292, USA
    J Neurophysiol 100:3225-35. 2008
    ..It was found that individual ED activity can be well measured in ED2, ED3, ED4, and extensor digiti minimi (EDM)...
  40. pmc Characterization of dengue virus complex-specific neutralizing epitopes on envelope protein domain III of dengue 2 virus
    Gregory D Gromowski
    Department of Pathology, Sealy Center for Vaccine Development, Center for Biodefense and Emerging Infectious Diseases, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas 77555 0609, USA
    J Virol 82:8828-37. 2008
    ..Each monomer consists of three domains (ED1, ED2, and ED3), of which ED3 contains the critical neutralization determinant(s)...
  41. doi Two novel mutations in the gene EDAR causing autosomal recessive hypohidrotic ectodermal dysplasia
    S K Naqvi
    Department of Biochemistry, Faculty of Biological Sciences, Quaid i Azam University, Islamabad, Pakistan
    Orthod Craniofac Res 14:156-9. 2011
    ..The HED exhibits X-linked, autosomal recessive and autosomal dominant mode of inheritance. Mutations in four genes including EDA, EDAR, EDARADD, and WNT10A are known to cause hypohidrotic and anhidrotic ectodermal dysplasia.
  42. doi ANG II receptor blockade enhances anti-inflammatory macrophages in anti-glomerular basement membrane glomerulonephritis
    Kaoru Aki
    Departmentsof Analytic Human Pathology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo, Japan
    Am J Physiol Renal Physiol 298:F870-82. 2010
    ..05). In addition, high-dose ARB reduced the numbers of ED3(+)-activated macrophages, suppressed glomerular TNF-alpha and IFN-gamma production, and downregulated M1-related ..
  43. doi Isolated oligodontia associated with mutations in EDARADD, AXIN2, MSX1, and PAX9 genes
    Birgitta Bergendal
    National Oral Disability Centre, The Institute for Postgraduate Dental Education, Jonkoping, Sweden
    Am J Med Genet A 155:1616-22. 2011
    ..we define the prevalence of mutations in the AXIN2, MSX1, PAX9, EDA, and EDAR genes, and the novel candidate gene EDARADD in a cohort of 93 Swedish probands with non-syndromic, isolated oligodontia...
  44. doi Specific detection of antibodies to different flaviviruses using a new immune complex ELISA
    Herbert Schmitz
    Department of Virology, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Str 74, 20359 Hamburg, Germany
    Med Microbiol Immunol 200:233-9. 2011
    ..IC ELISAs were applied to detect human IgG antibodies to the highly virus-specific ED3 domain of West Nile- and tick-borne encephalitis virus envelopes...
  45. doi Molecular genetic analysis of consanguineous Pakistani families with autosomal recessive hypohidrotic ectodermal dysplasia
    Nosheen Bibi
    Department of Biotechnology, Faculty of Biological Sciences, Quaid i Azam University, Islamabad, Pakistan
    Australas J Dermatol 52:37-42. 2011
    ..gene, and autosomal forms of hypohidrotic ectodermal dysplasia are caused by mutations in either the EDAR or the EDARADD genes...
  46. doi Comparative analysis of the phenotypic characteristics of high- and low-virulent strains of Edwardsiella tarda
    Y Wang
    Department of Marine Biology, Ocean University of China, Qingdao, China
    J Fish Dis 33:985-94. 2010
    ..Based on the database search with MALDI-TOF MS data, the closest homologies of the three protein bands Ed1, Ed2 and Ed3 were phosphotransferase enzyme family protein, nitrite reductase [NAD(P)H], large subunit and ATP-dependent Lon ..
  47. doi A missense mutation in the death domain of EDAR abolishes the interaction with EDARADD and underlies hypohidrotic ectodermal dysplasia
    Yukiko Masui
    Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Dermatology 223:74-9. 2011
    ..X-linked form of HED is caused by mutations in the EDA gene, while autosomal forms are caused by mutations in either EDAR or EDARADD genes.
  48. pmc Genome-wide association scan for childhood caries implicates novel genes
    J R Shaffer
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    J Dent Res 90:1457-62. 2011
    ..met strict criteria for genome-wide significance (p < 10E-7); however, several loci (ACTN2, MTR, and EDARADD, MPPED2, and LPO) with plausible biological roles in dental caries exhibited suggestive evidence for association...
  49. doi Only four genes (EDA1, EDAR, EDARADD, and WNT10A) account for 90% of hypohidrotic/anhidrotic ectodermal dysplasia cases
    Céline Cluzeau
    Universite Paris Descartes, INSERM U, Hopital Necker Enfants Malades, France
    Hum Mutat 32:70-2. 2011
    ..genes have been hitherto identified, namely, (1) EDA1 accounting for X-linked forms, (2) EDAR, and (3) EDARADD, causing both autosomal dominant and recessive forms...
  50. doi Mutations of an antibody binding energy hot spot on domain III of the dengue 2 envelope glycoprotein exploited for neutralization escape
    Gregory D Gromowski
    Department of Pathology, Sealy Center for Vaccine Development, and Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Virology 407:237-46. 2010
    Previous crystallographic studies have identified a total of 11 DENV-2 envelope protein domain III (ED3) residues (K305, F306, K307, V308, V309, K310, I312, Q325, P364, K388, and N390) that interacted, through both side- and main-chain ..
  51. pmc Statin attenuates experimental anti-glomerular basement membrane glomerulonephritis together with the augmentation of alternatively activated macrophages
    Emiko Fujita
    Department of Analytic Human Pathology, Nippon Medical School, Tokyo, Japan
    Am J Pathol 177:1143-54. 2010
    ..The number of glomerular ED3-positive macrophages decreased with down-regulation of M1 macrophage-associated cytokines...
  52. doi A Mongolian patient with hypohidrotic ectodermal dysplasia with a novel P121S variant in EDARADD
    N Suda
    Maxillofacial Orthognathics, Division of Maxillofacial Neck Reconstruction, Department of Maxillofacial Reconstruction and Function, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
    Orthod Craniofac Res 13:114-7. 2010
    ..Three genes, EDA, EDAR, and EDARADD, all related to tumor necrosis factor signaling, have been reported as responsible genes for this disorder...
  53. pmc An in-depth analysis of original antigenic sin in dengue virus infection
    Claire M Midgley
    Department of Medicine, Hammersmith Hospital Campus, Imperial College London, London, United Kingdom
    J Virol 85:410-21. 2011
    ..Domain 3 of the dengue virus envelope protein (ED3) has been suggested as one such candidate because it contains neutralizing epitopes and it was originally thought ..
  54. doi Effects of mechanical loading on early conduction system differentiation in the chick
    Barbora Sankova
    Institute of Anatomy, First Faculty of Medicine, U nemocnice 3, Prague 2, Czech Republic
    Am J Physiol Heart Circ Physiol 298:H1571-6. 2010
    ..We then tested the effects of hemodynamic unloading in the organ culture system upon its functionality. In ED3 hearts cultured without hemodynamic loading for 24 h, we observed a significant decrease in the percentage ..
  55. doi Mutations in EDARADD account for a small proportion of hypohidrotic ectodermal dysplasia cases
    N Chassaing
    INSERM, U563, Centre de Physiopathologie de Toulouse Purpan, Toulouse, F 31300 France
    Br J Dermatol 162:1044-8. 2010
    ..Autosomal dominant and recessive forms occasionally occur and result from mutations in at least two other genes: EDAR and EDARADD. EDARADD interacts with the TAB2/TRAF6/TAK1 complex, which is necessary for NF-kappaB activation by EDAR.
  56. doi Anatomic basis for individuated surface EMG and homogeneous electrostimulation with neuroprostheses of the extensor digitorum communis
    J N A L Leijnse
    Department of Mechanical Engineering, Speed School of Engineering, University of Louisville, Louisville, Kentucky 40292, USA
    J Neurophysiol 100:64-75. 2008
    ..The ED parts to the individual fingers consistently arise from distinct OT locations: the ED3 (medius) arises proximally, the ED2 (index) from the radial slip distal to ED3, the ED4 (ring finger) from the ..
  57. pmc Ocular and systemic bio-distribution of rhodamine-conjugated liposomes loaded with VIP injected into the vitreous of Lewis rats
    S Camelo
    Center de Recherche des Cordeliers, Université Pierre et Marie Curie Paris, Paris, France
    Mol Vis 13:2263-74. 2007
    ....
  58. pmc The surface-exposed carboxyl region of Mycoplasma pneumoniae elongation factor Tu interacts with fibronectin
    Sowmya Balasubramanian
    Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Infect Immun 76:3116-23. 2008
    ..Further analysis of carboxyl constructs (ED3 and ED4) and their deletion truncations (ED3.1, ED3.2, and ED4...
  59. ncbi The activation level of the TNF family receptor, Edar, determines cusp number and tooth number during tooth development
    A S Tucker
    Craniofacial Development, Dental Institute, Guy s Hospital, King s College London, London SE1 9RT, UK
    Dev Biol 268:185-94. 2004
    Mutations in members of the ectodysplasin (TNF-related) signalling pathway, EDA, EDAR, and EDARADD in mice and humans produce an ectodermal dysplasia phenotype that includes missing teeth and smaller teeth with reduced cusps...
  60. ncbi Developmental changes of keratin expression in chick embryo olfactory epithelium in relation to cellular differentiation and neurogenesis in vivo and in vitro
    Isabelle Comte
    UMR CNRS 6101, Faculte de Medecine, 2 rue du Dr Marcland, 87025 Limoges, Cedex, France
    Brain Res Dev Brain Res 148:1-10. 2004
    ..Olfactory placodes form at embryonic day 3 (ED3) in the anterior facial ectoderm and invaginate to form the nasal pits...
  61. pmc Myodegeneration in EDA-A2 transgenic mice is prevented by XEDAR deficiency
    Kim Newton
    Molecular Oncology Department, Genentech, Inc, South San Francisco, California 94080, USA
    Mol Cell Biol 24:1608-13. 2004
    ..an important role in sweat gland, hair, and tooth development; mutations in EDA, EDAR, or the downstream adaptor EDARADD cause hypohidrotic ectodermal dysplasia...
  62. ncbi Traf6 is essential for murine tooth cusp morphogenesis
    Atsushi Ohazama
    Department of Craniofacial Development, GKT Dental Institute, King s College, Guy s Hospital, London Bridge, London, United Kingdom
    Dev Dyn 229:131-5. 2004
    ..e., ectodysplasin (EDA), EDA receptor (EDAR), and EDAR-associated death domain (EDARADD; the intracellular adaptor for EDAR), are responsible for several forms of HED in humans and mice...
  63. ncbi Heterogeneity of macrophages in the rat evidenced by variability in determinants: two new anti-rat macrophage antibodies against a heterodimer of 160 and 95 kd (CD11/CD18)
    J G Damoiseaux
    Department of Cell Biology Medical Faculty, Vrije Universiteit, Amsterdam, The Netherlands
    J Leukoc Biol 46:556-64. 1989
    A set of three monoclonal antibodies (MoAbs), ED1, ED2, and ED3, has been shown to recognize in situ different subsets of macrophages in the rat...
  64. ncbi Mesh implants in hernia repair. Inflammatory cell response in a rat model
    R Rosch
    Department of Surgery, RWTH Aachen University, Aachen, Germany
    Eur Surg Res 35:161-6. 2003
    ..To approach biocompatibility of surgical meshes we therefore examined the infiltrate of these cells as well as the proliferation rate in response to different clinically applied materials...
  65. ncbi Death receptor signaling giving life to ectodermal organs
    Irma Thesleff
    Developmental Biology Program, Insitute of Biotechnology, Viikki Biocenter, PO Box 56, University of Helsinki, 00014 Helsinki, Finland
    Sci STKE 2002:pe22. 2002
    ..also known as EDA), its death domain-containing receptor EDAR, and the death domain adapter molecule EDARADD. This pathway was discovered and delineated through the cloning of genes that cause human hypohidrotic ectodermal ..
  66. ncbi Identification of a novel death domain-containing adaptor molecule for ectodysplasin-A receptor that is mutated in crinkled mice
    Minhong Yan
    Department of Molecular Oncology, Genentech Inc, South San Francisco, CA 94080, USA
    Curr Biol 12:409-13. 2002
    ..This is an unprecedented example of naturally occurring mutations in ligand, receptor, or adaptor giving rise to the same phenotypic disease characterized by a defect in the proper development of epidermal appendages...
  67. ncbi Gene defect in ectodermal dysplasia implicates a death domain adapter in development
    D J Headon
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, 77030, USA
    Nature 414:913-6. 2001
    ..This adapter, which we have called Edaradd (for Edar-associated death domain), interacts with the death domain of Edar and links the receptor to downstream ..
  68. ncbi In vitro characterization of Mato's FGP cells isolated from rat cerebrum
    Tomoko Nakazawa
    Department of Anatomy and Developmental Biology, Medical School, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Neurosci Lett 317:127-30. 2002
    ..immunoreactions of cultured cells to ED1 and ED2 antibodies were observed, whereas they were weak or negative to ED3 and OX42 antibodies. Acid phosphatase activity was detected in the granules of cultured cells...
  69. ncbi Blockade of complement inhibits obliterative bronchiolitis in rat tracheal allografts
    E A Kallio
    Cardiopulmonary Research Group of the Transplantation Laboratory, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Am J Respir Crit Care Med 161:1332-9. 2000
    ..treatment did not affect the number of graft-infiltrating CD4(+) and CD8(+) T cells, CD45(+) B cells, ED1(+) and ED3(+) macrophages, or immune activation with expression of IL-2Ralpha or MHC class II...
  70. ncbi Mutations in the human homologue of mouse dl cause autosomal recessive and dominant hypohidrotic ectodermal dysplasia
    A W Monreal
    Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201, USA
    Nat Genet 22:366-9. 1999
    ..Dominant disorders, possibly allelic to the recessive loci, are seen in both species (ED3, Dlslk)...
  71. ncbi Transitions in cell organization and in expression of contractile and extracellular matrix proteins during development of chicken aortic smooth muscle: evidence for a complex spatial and temporal differentiation program
    Z Yablonka-Reuveni
    Department of Biological Structure, School of Medicine, University of Washington, Seattle 98195, USA
    Anat Embryol (Berl) 197:421-37. 1998
    ..We further show that, during earlier stages of embryogenesis (ED3 through ED7), cells expressing smooth muscle proteins appear only in the peri-endothelial region of the aortic and ..
  72. ncbi Marrow-derived activated macrophages are required during the effector phase of experimental autoimmune uveoretinitis in rats
    J V Forrester
    Department of Ophthalmology, University of Aberdeen, Scotland
    Curr Eye Res 17:426-37. 1998
    ..Immunohistochemical studies have previously documented the lymphocyte profiles during various stages of the disease process. The purpose of the present study was to investigate the role of macrophages in EAU...
  73. ncbi Phenotypic characterization of mononuclear inflammatory cells in salivary glands of bio-breeding rats
    R E Cohen
    Department of Periodontology, School of Dental Medicine, University at Buffalo, NY 14214, USA
    Arch Oral Biol 42:649-55. 1997
    ..membrane antigens associated primarily with monocytes (ED1), mature tissue macrophages (ED2), lymphoid macrophages (ED3), MHC class II (Ia) antigen (OX6), CD5+ T lymphocytes (OX19), and rat B lymphocytes (OX33)...
  74. pmc Role of nitric oxide in experimental obliterative bronchiolitis (chronic rejection) in the rat
    E A Kallio
    Cardiopulmonary Research Group of Transplantation Laboratory, Haartman Institute, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    J Clin Invest 100:2984-94. 1997
    ..of the nitric oxide pathway affected the number of graft-infiltrating CD4+ and CD8+ T cells, ED1+ and ED3+ macrophages, immune activation with expression of IL-2R or MHC class II, or production of macrophage or Th1 ..
  75. ncbi Pulse pressure correlates in humans with a proscillaridin A immunoreactive compound
    B Sich
    Institut für Biochemie und Endokrinologie, Justus Liebig Universitat Giessen, Germany
    Hypertension 27:1073-8. 1996
    ..a propanol/isopropanol gradient resulted in the separation of three peaks of increasing hydrophobicity (ED1, ED2, ED3) that inhibited the sodium pump of human red blood cells and cross-reacted with proscillaridin A antibodies...
  76. ncbi Fractalkine and its receptor, CX3CR1, upregulation in streptozotocin-induced diabetic kidneys
    Yuichi Kikuchi
    Second Department of Internal Medicine, National Defense Medical College, Saitama, Japan
    Nephron Exp Nephrol 97:e17-25. 2004
    ..We examined whether fractalkine and CX3CR1 upregulation are found in streptozotocin-induced diabetic kidneys...
  77. ncbi A rare case of hypohidrotic ectodermal dysplasia caused by compound heterozygous mutations in the EDAR gene
    Yutaka Shimomura
    Department of Dermatology, Niigata University School of Medicine, Niigata, Japan
    J Invest Dermatol 123:649-55. 2004
    ..caused by mutations in the EDA gene, and the autosomal forms result from mutations in either the EDAR gene or the EDARADD gene...
  78. pmc Is the hair follicle necessary for normal wound healing?
    Mayumi Ito
    Department of Dermatology, Kligman Laboratories, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Invest Dermatol 128:1059-61. 2008
    ..To address this question, Langton et al. (this issue, 2008) take advantage of the Edaradd mutant mouse, which lacks hair follicles on its tail...
  79. ncbi Long range communication in the envelope protein domain III and its effect on the resistance of West Nile virus to antibody-mediated neutralization
    Rodrigo A Maillard
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555 1055, USA
    J Biol Chem 283:613-22. 2008
    The envelope protein domain III (ED3) of West Nile virus is the major virus-specific neutralization domain and harbors most of the critical mutations that induce resistance against antibody-mediated neutralization...
  80. ncbi Characterization of an antigenic site that contains a dominant, type-specific neutralization determinant on the envelope protein domain III (ED3) of dengue 2 virus
    Gregory D Gromowski
    Department of Pathology, Sealy Center for Vaccine Development, Center for Biodefense and Emerging Infectious Diseases, and Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Virology 366:349-60. 2007
    ..The E protein ectodomain can be divided into three structural domains designated ED1, ED2, and ED3, of which ED3 contains the critical and dominant virus-specific neutralization sites...
  81. ncbi Mapping to completeness and transplantation of a group-specific, discontinuous, neutralizing epitope in the envelope protein of dengue virus
    Olesia Lisova
    Unit of Molecular Prevention and Therapy of Human Diseases CNRS URA3012, Institut Pasteur, 28 rue Docteur Roux, F 75724 Paris Cedex 15, France
    J Gen Virol 88:2387-97. 2007
    ..of antibody mAb4E11, which neutralizes the four serotypes of DENV but no other flavivirus, and binds domain 3 (ED3) of their envelope glycoprotein, was characterized...
  82. ncbi Establishment of immortalized rat Kupffer cell lines
    Yanhua Peng
    James A Haley Veterans Affairs Medical Center, Department of Surgery, University of South Florida Health Sciences Center, C O Tampa General Hospital, Tampa, FL 33601, USA
    Cytokine 37:185-91. 2007
    ..Primary cultures of Kupffer cells have a very limited life span, tend to de-differentiate and become senescent, and therefore are not suitable for cell signaling studies...
  83. ncbi A novel 4-bp insertion mutation in EDA1 gene in a Pakistani family with X-linked hypohidrotic ectodermal dysplasia
    Muhammad Tariq
    Department of Biochemistry, Faculty of Biological Sciences, Quaid i Azam University, Islamabad, Pakistan
    Eur J Dermatol 17:209-12. 2007
    ..Mutations in the EDA 1 gene cause X-linked HED and mutations in either EDAR or EDARADD genes cause autosomal forms of HED...
  84. ncbi Hypocellularity and absence of compaction as criteria for embryonic death
    Donald W Landry
    Division of Experimental Therapeutics, Columbia University, New York, NY 10032, USA
    Regen Med 1:367-71. 2006
    ..For developed humans, life is considered to end when the criteria for brain death are met, but corresponding criteria are lacking for human embryos, and thus, we undertook a natural history study of embryonic death...
  85. ncbi Bacterial growth yields on EDTA, NTA, and their biodegradation intermediates
    Zhiwen Yuan
    Department of Civil, Environmental, and Architectural Engineering, University of Colorado at Boulder, Engineering Center ECOT 441, UCB 428, Boulder, CO 80309, USA
    Biodegradation 19:41-52. 2008
    ..0 g of cell dry weight (CDW) (mole of EDTA)(-1), 68.6 g of CDW (mole of ED3 A)(-1), 51.2 g of CDW (mole of N,N'-EDDA)(-1), 34.5 g of CDW (mole of ED)(-1), 26.3 g of CDW (mole of IDA)(-1), 12...
  86. pmc Solution structure of the envelope protein domain III of dengue-4 virus
    David E Volk
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555 1157, USA
    Virology 364:147-54. 2007
    ..Using NMR spectroscopic methods, we solved the solution structure of domain III (ED3), the receptor-binding domain, of the envelope protein of DEN4 virus, human strain 703-4...
  87. pmc EDA signaling and skin appendage development
    Chang Yi Cui
    Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Cell Cycle 5:2477-83. 2006
    ..EDA signaling is mediated by ectodysplasin, EDAR and EDARADD, which form a new TNF ligand-receptor-adaptor family that is restricted to skin appendages in vertebrates from ..
  88. ncbi Limited capability of regional lymph nodes to eradicate metastatic cancer cells
    Hiroshi Nagata
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Cancer Res 64:8239-48. 2004
    ..Germinal centers and lymphoid cells in the medulla proliferated before 48 hours. ED3(+) macrophages incorporated apoptotic cancer cells, but significant cancer proliferation occurred after 4 days...
  89. ncbi Tissue response to partially in vitro predegraded poly-L-lactide implants
    Wim H De Jong
    Laboratory for Toxicology, Pathology and Genetics, National Institute for Public Health and the Environment, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Biomaterials 26:1781-91. 2005
    ..In the capsule macrophage like cells expressed all three macrophage markers ED1, ED2, and ED3. CD4 and CD8 positive cells, indicating T helper and T supressor/cytotoxic cells, respectively, could be observed ..
  90. ncbi Energy density of diets reported by American adults: association with food group intake, nutrient intake, and body weight
    A K Kant
    Department of Family, Nutrition, and Exercise Sciences, Queens College of the City University of New York, Flushing, NY 11367, USA
    Int J Obes (Lond) 29:950-6. 2005
    ..However, little is known about the energy density of diets consumed by free-living populations; therefore, the purpose of this study was to examine demographic, health, and nutritional correlates of energy density of self-reported diets...
  91. ncbi Intercellular growth factor signaling and the development of mouse tracheal submucosal glands
    Emma L Rawlins
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Dev Dyn 233:1378-85. 2005
    ..Glands are completely absent in mice lacking Ectodysplasin (Eda) and Edaradd (Eda receptor adaptor protein), members of the tumor necrosis (TNF) superfamily of signaling factors...
  92. ncbi TAB2, TRAF6 and TAK1 are involved in NF-kappaB activation induced by the TNF-receptor, Edar and its adaptator Edaradd
    Aurore Morlon
    Unité de Recherche sur les Handicaps Génétiques de l Enfant INSERM U 393, Hopital Necker Enfants Malades, 149 rue de Sévres 75015 Paris, France
    Hum Mol Genet 14:3751-7. 2005
    Activation of the NF-kappaB pathway by the TNF-receptor Edar (Ectodysplasin receptor) and its downstream adaptator Edaradd (Edar-associated death domain) is essential for the development of hair follicles, teeth, exocrine glands and ..
  93. ncbi Mutations in EDAR account for one-quarter of non-ED1-related hypohidrotic ectodermal dysplasia
    N Chassaing
    Service de Genetique Medicale, Hopital Purpan, Toulouse, France
    Hum Mutat 27:255-9. 2006
    ..and -recessive forms occur occasionally and result from mutations in at least two genes: EDAR and EDARADD. These different forms are phenotypically indistinguishable...
  94. ncbi [Prokaryotic expression and identification of human papillomavirus type 16 E5 protein]
    Qiao fa Shi
    Department of Microbiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China
    Nan Fang Yi Ke Da Xue Xue Bao 26:31-5. 2006
    ..To construct the prokaryotic and eukaryotic expression vectors pET32/E5 and pcDNA3.1/E5 for transformation into E. coli BL21 and NIH(3)T(3) cells respectively to observe the expression of human papillomavirus type 16 E5 protein (HPV16 E5)...
  95. ncbi [Pulmonary macrophages in rats after hemithoracic irradiation: analysis of morphology and expression of surface antigen]
    K Soejima
    Department of Radiology, Yamaguchi University School of Medicine, Ube, Japan
    Nihon Kyobu Shikkan Gakkai Zasshi 31:942-50. 1993
    ..monoclonal antibodies to MHC class I (HAM2), MHC class II (OX6) and macrophage differentiation antigens (ED1, ED2, ED3)...
  96. pmc Definitive evidence for an autosomal recessive form of hypohidrotic ectodermal dysplasia clinically indistinguishable from the more common X-linked disorder
    F Munoz
    Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201, USA
    Am J Hum Genet 61:94-100. 1997
    ....
  97. ncbi The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A
    A Kumar
    Hamon Center for Therapeutic Oncology Research and the Division of Hematology Oncology, University of Texas Southwestern Medical Center, Dallas 75390 8593, USA
    J Biol Chem 276:2668-77. 2001
    ..Collectively, the above results suggest that EDAR utilizes a novel signal transduction pathway. Finally, ectodysplasin A can physically interact with the extracellular domain of EDAR and thus represents its biological ligand...

Research Grants33

  1. Antiviral Agents directed at West Nile Virus
    STEVEN WHITTEN; Fiscal Year: 2004
    ..Binding and structural studies will be carried out against the West Nile envelope protein Domain III (WN-ED3)...
  2. BLOOD PLATELET THROMBOXANE RECEPTORS
    GUY LEBRETON; Fiscal Year: 2007
    ..2. Map the TPR ligand-binding pocket. Our hypothesis is that ligands dock at C-terminal ED3 and interact with residues in TM5 and/or N-terminal ED4...
  3. Myogenic Stem Cell Function in Aging Skeletal Muscle
    Zipora Yablonka Reuveni; Fiscal Year: 2006
    ..The proposed investigation will contribute new insight into the status of myogenic precursors in the adult and aging muscle and can prove important for muscle rehabilitation strategies during disease and aging. ..
  4. CORE--CHEMISTRY
    Donald Landry; Fiscal Year: 2007
    ..Radiolabeled Photoaffinity Analogs X VI. Photoaffinity Analogs Tethered for Affinity Purification X PHS 398/2590 (Rev. 09/04) Page 2~ Continuation Format Page ..
  5. Satellite Cells and Skeletal Muscle Growth Dynamics
    Zipora Yablonka Reuveni; Fiscal Year: 2007
    ..The proposed investigation will contribute to a better understanding of satellite cell dynamics and muscle growth, and can prove important for muscle rehabilitation strategies during disease and aging. ..
  6. Myogenic stem cells in extraocular muscles
    Zipora Yablonka Reuveni; Fiscal Year: 2009
    ....
  7. Myogenic Stem Cell Function in Aging Skeletal Muscle
    Zipora Yablonka Reuveni; Fiscal Year: 2010
    ..The proposed studies will contribute new insight into the regulation of satellite cell function throughout the lifespan and will, therefore, provide important information for muscle rehabilitation strategies during disease and aging. ..
  8. Myogenic stem cells in extraocular muscles
    Zipora Yablonka Reuveni; Fiscal Year: 2010
    ....
  9. Trends in food consumption patterns of Americans
    ASHIMA KANT; Fiscal Year: 2005
    ..abstract_text> ..
  10. Myogenic Stem Cell Function in Aging Skeletal Muscle
    Zipora Yablonka Reuveni; Fiscal Year: 2002
    ..The proposed investigation will contribute new insight into the status of myogenic precursors in the adult and aging muscle and can prove important for muscle rehabilitation strategies during disease and aging. ..
  11. Relation of diet quality with mortality
    ASHIMA KANT; Fiscal Year: 2002
    ..abstract_text> ..
  12. Dietary pattern indexes: relation with CVD risk factors
    ASHIMA KANT; Fiscal Year: 2003
    ..We will use dietary, anthropometric, biochemical, and health data from the third National Health and Nutrition Examination Survey, 1988-1994 (>15,000), to address these issues. ..
  13. Trends in socioeconomic position and diet relationship
    ASHIMA KANT; Fiscal Year: 2005
    ..The proposed study will thus contribute to progress towards the stated goals of Healthy People 2010 and the National Cancer Institute. ..
  14. Myogenic Stem Cell Function in Aging Skeletal Muscle
    Zipora Yablonka Reuveni; Fiscal Year: 2009
    ..The proposed studies will contribute new insight into the regulation of satellite cell function throughout the lifespan and will, therefore, provide important information for muscle rehabilitation strategies during disease and aging. ..