ectodysplasin A


Gene Symbol: ectodysplasin A
Description: ectodysplasin A
Alias: ECTD1, ED1, ED1-A1, ED1-A2, EDA-A1, EDA-A2, EDA1, EDA2, HED, HED1, ODT1, STHAGX1, TNLG7C, XHED, XLHED, ectodysplasin-A, X-linked anhidroitic ectodermal dysplasia protein, oligodontia 1, tumor necrosis factor ligand 7C
Species: human
Products:     ectodysplasin A

Top Publications

  1. Mues G, Griggs R, Hartung A, Whelan G, Best L, Srivastava A, et al. From ectodermal dysplasia to selective tooth agenesis. Am J Med Genet A. 2009;149A:2037-41 pubmed publisher
    The history and the lessons learned from hypohidrotic ectodermal dysplasia (HED) may serve as an example for the unraveling of the cause and pathogenesis of other ectodermal dysplasia syndromes by demonstrating that phenotypically ..
  2. Vincent M, Biancalana V, Ginisty D, Mandel J, Calvas P. Mutational spectrum of the ED1 gene in X-linked hypohidrotic ectodermal dysplasia. Eur J Hum Genet. 2001;9:355-63 pubmed
    X-linked hypohidrotic ectodermal dysplasia (XLHED) is the most common form of the ectodermal dysplasias characterised by an abnormal development of eccrine sweat glands, hair and teeth...
  3. Cluzeau C, Hadj Rabia S, Jambou M, Mansour S, Guigue P, Masmoudi S, et al. Only four genes (EDA1, EDAR, EDARADD, and WNT10A) account for 90% of hypohidrotic/anhidrotic ectodermal dysplasia cases. Hum Mutat. 2011;32:70-2 pubmed publisher
    ..Three disease-causing genes have been hitherto identified, namely, (1) EDA1 accounting for X-linked forms, (2) EDAR, and (3) EDARADD, causing both autosomal dominant and recessive forms...
  4. Li S, Li J, Cheng J, Zhou B, Tong X, Dong X, et al. Non-syndromic tooth agenesis in two Chinese families associated with novel missense mutations in the TNF domain of EDA (ectodysplasin A). PLoS ONE. 2008;3:e2396 pubmed publisher
    ..The EDA gene has been reported responsible for X-linked hypohidrotic ectodermal dysplasia (XLHED) in humans characterized by impaired development of hair, eccrine sweat glands, and teeth...
  5. Mues G, Tardivel A, Willen L, Kapadia H, Seaman R, Frazier Bowers S, et al. Functional analysis of Ectodysplasin-A mutations causing selective tooth agenesis. Eur J Hum Genet. 2010;18:19-25 pubmed publisher
    ..Our study reveals that expression, receptor binding or signaling capability of the mutant EDA1 proteins is only impaired in contrast to syndrome-causing mutations, which we have previously shown to abolish EDA1 ..
  6. Elomaa O, Pulkkinen K, Hannelius U, Mikkola M, Saarialho Kere U, Kere J. Ectodysplasin is released by proteolytic shedding and binds to the EDAR protein. Hum Mol Genet. 2001;10:953-62 pubmed
    ..We conclude that as a soluble ligand, ectodysplasin is able to interact with EDAR and mediate signals needed for the development of ectodermal appendages. ..
  7. Fan H, Ye X, Shi L, Yin W, Hua B, Song G, et al. Mutations in the EDA gene are responsible for X-linked hypohidrotic ectodermal dysplasia and hypodontia in Chinese kindreds. Eur J Oral Sci. 2008;116:412-7 pubmed publisher
    ..Previous studies found that mutations in the ectodysplasin A (EDA) gene are associated with XLHED...
  8. Song S, Han D, Qu H, Gong Y, Wu H, Zhang X, et al. EDA gene mutations underlie non-syndromic oligodontia. J Dent Res. 2009;88:126-31 pubmed publisher
    ..detected mutations in the EDA gene, previously identified as causing X-linked hypohidrotic ectodermal dysplasia (XLHED), in two families with X-linked non-syndromic hypodontia...
  9. Pillas D, Hoggart C, Evans D, O Reilly P, Sipilä K, Lähdesmäki R, et al. Genome-wide association study reveals multiple loci associated with primary tooth development during infancy. PLoS Genet. 2010;6:e1000856 pubmed publisher
    ..Genes at four of the identified loci are implicated in the development of cancer. A variant within the HOXB gene cluster associated with occlusion defects requiring orthodontic treatment by age 31 years. ..

More Information

Publications117 found, 100 shown here

  1. Monreal A, Zonana J, Ferguson B. Identification of a new splice form of the EDA1 gene permits detection of nearly all X-linked hypohidrotic ectodermal dysplasia mutations. Am J Hum Genet. 1998;63:380-9 pubmed
    X-linked hypohidrotic ectodermal dysplasia (XLHED), the most common of the ectodermal dysplasias, results in the abnormal development of teeth, hair, and eccrine sweat glands...
  2. Tao R, Jin B, Guo S, Qing W, Feng G, Brooks D, et al. A novel missense mutation of the EDA gene in a Mongolian family with congenital hypodontia. J Hum Genet. 2006;51:498-502 pubmed
    ..1, and then found a novel missense mutation, c.193C>G, in the ectodysplasin A (EDA) gene in all affected males and carrier females...
  3. Headon D, Emmal S, Ferguson B, Tucker A, Justice M, Sharpe P, et al. Gene defect in ectodermal dysplasia implicates a death domain adapter in development. Nature. 2001;414:913-6 pubmed
    ..Our findings show that the death receptor/adapter signalling mechanism is conserved in developmental, as well as apoptotic, signalling. ..
  4. Han D, Gong Y, Wu H, Zhang X, Yan M, Wang X, et al. Novel EDA mutation resulting in X-linked non-syndromic hypodontia and the pattern of EDA-associated isolated tooth agenesis. Eur J Med Genet. 2008;51:536-46 pubmed publisher
  5. Zhang J, Han D, Song S, Wang Y, Zhao H, Pan S, et al. Correlation between the phenotypes and genotypes of X-linked hypohidrotic ectodermal dysplasia and non-syndromic hypodontia caused by ectodysplasin-A mutations. Eur J Med Genet. 2011;54:e377-82 pubmed publisher
    Mutations in the ectodysplasin-A (EDA) gene can cause both X-linked hypohidrotic ectodermal dysplasia (XLHED) and non-syndromic hypodontia (NSH)...
  6. Kere J, Srivastava A, Montonen O, Zonana J, Thomas N, Ferguson B, et al. X-linked anhidrotic (hypohidrotic) ectodermal dysplasia is caused by mutation in a novel transmembrane protein. Nat Genet. 1996;13:409-16 pubmed
    ..The gene is expressed in keratinocytes, hair follicles, and sweat glands, and in other adult and fetal tissues. The predicted EDA protein may belong to a novel class with a role in epithelial-mesenchymal signalling. ..
  7. Kumar A, Eby M, Sinha S, Jasmin A, Chaudhary P. The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A. J Biol Chem. 2001;276:2668-77 pubmed
    ..Collectively, the above results suggest that EDAR utilizes a novel signal transduction pathway. Finally, ectodysplasin A can physically interact with the extracellular domain of EDAR and thus represents its biological ligand.
  8. Hymowitz S, Compaan D, Yan M, Wallweber H, Dixit V, Starovasnik M, et al. The crystal structures of EDA-A1 and EDA-A2: splice variants with distinct receptor specificity. Structure. 2003;11:1513-20 pubmed
    ..While the backbone conformation around the splice difference is similar in both isoforms, the conformation of the following loop, the surface charge, and the shape of the expected receptor binding site differ significantly. ..
  9. Yang Y, Luo L, Xu J, Zhu P, Xue W, Wang J, et al. Novel EDA p.Ile260Ser mutation linked to non-syndromic hypodontia. J Dent Res. 2013;92:500-6 pubmed publisher
    ..Mutations in the ectodysplasin-A (EDA) gene can lead to both X-linked hypohidrotic ectodermal dysplasia (XLHED) and non-syndromic hypodontia (NSH)...
  10. Bayes M, Hartung A, Ezer S, Pispa J, Thesleff I, Srivastava A, et al. The anhidrotic ectodermal dysplasia gene (EDA) undergoes alternative splicing and encodes ectodysplasin-A with deletion mutations in collagenous repeats. Hum Mol Genet. 1998;7:1661-9 pubmed
    ..Our results will allow mutation diagnostics in the majority of patients. ..
  11. Tarpey P, Pemberton T, Stockton D, Das P, Ninis V, Edkins S, et al. A novel Gln358Glu mutation in ectodysplasin A associated with X-linked dominant incisor hypodontia. Am J Med Genet A. 2007;143:390-4 pubmed
  12. Ezer S, Bayes M, Elomaa O, Schlessinger D, Kere J. Ectodysplasin is a collagenous trimeric type II membrane protein with a tumor necrosis factor-like domain and co-localizes with cytoskeletal structures at lateral and apical surfaces of cells. Hum Mol Genet. 1999;8:2079-86 pubmed
    ..Our results suggest that ectodysplasin is a new member in the TNF-related ligand family involved in the early epithelial-mesenchymal interaction that regulates ectodermal appendage formation. ..
  13. Arif T, Amin S, Adil M, Mohtashim M. Diffuse Palmoplantar Keratoderma, Onychodystrophy, universal Hypotrichosis and Cysts. Acta Dermatovenerol Croat. 2017;25:161-163 pubmed
    Dear Editor, Clouston syndrome, also called hidrotic ectodermal dysplasia (HED), is an autosomal dominant ectodermal dysplasia characterized by a clinical triad of onychodystrophy, generalized hypotrichosis, and palmoplantar keratoderma (..
  14. Liu Y, Huang Y, Hua R, Zhao X, Yang W, Liu Y, et al. Mutation Screening of the EDA Gene in Seven Chinese Families with X-Linked Hypohidrotic Ectodermal Dysplasia. Genet Test Mol Biomarkers. 2018;22:487-491 pubmed publisher
    As the most common form of ectodermal dysplasia (ED), X-linked hypohidrotic ED (XLHED) is characterized by the triad of hypohidrosis, hypotrichosis, and anodontia in male patients. The gene responsible for XLHED is EDA...
  15. Petersheim D, Massaad M, Lee S, Scarselli A, Cancrini C, Moriya K, et al. Mechanisms of genotype-phenotype correlation in autosomal dominant anhidrotic ectodermal dysplasia with immune deficiency. J Allergy Clin Immunol. 2018;141:1060-1073.e3 pubmed publisher
    ..IκBα point mutants accumulate at higher levels compared with truncation mutants and are associated with more severe disease and greater impairment of canonical and noncanonical NF-κB activity in patients with AD EDA-ID. ..
  16. Piña Aguilar R, González Ortega C, Calull Bago A, Lanuza López M, Cancino Villarreal P, Gutiérrez Gamiño A, et al. [Combined Preimplantation Genetic Testing for Aneuploidy and Monogenic Disease in a Mexican Family Affected by X-linked Hypohidrotic Ectodermal Dysplasia]. Rev Invest Clin. 2018;70:164-168 pubmed publisher
    Hypohidrotic ectodermal dysplasia (HED) is a genetic skin condition presenting as hypohidrosis, hypodontia, and hypotrichosis, resulting in an important burden for affected families...
  17. Awazawa M, Gabel P, Tsaousidou E, Nolte H, Kruger M, Schmitz J, et al. A microRNA screen reveals that elevated hepatic ectodysplasin A expression contributes to obesity-induced insulin resistance in skeletal muscle. Nat Med. 2017;23:1466-1473 pubmed publisher
    ..Our approach revealed that expression of both the gene encoding ectodysplasin A (Eda), the causal gene in X-linked hypohidrotic ectodermal dysplasia (XLHED), and its intronic miRNA, miR-676,..
  18. Callea M, Yavuz I, Clarich G, Cammarata Scalisi F. [Clinical and molecular study in a child with X-linked hypohidrotic ectodermal dysplasia]. Arch Argent Pediatr. 2015;113:e341-4 pubmed
    ..We present a child evaluated in a multidisciplinary manner with clinical and molecular diagnosis of X-linked hypohidrotic ectodermal dysplasia with type missense mutation c.1133C> T; p.T378M in EDA gene. ..
  19. Boisson B, Puel A, Picard C, Casanova J. Human I?B? Gain of Function: a Severe and Syndromic Immunodeficiency. J Clin Immunol. 2017;37:397-412 pubmed publisher
  20. Deshmukh S, Prashanth S. Ectodermal dysplasia: a genetic review. Int J Clin Pediatr Dent. 2012;5:197-202 pubmed publisher
    ..The history and lessons learned from hypohidrotic ectodermal dysplasia (HED) may serve as an example for unraveling of the cause and pathogenesis of other ectodermal dysplasia syndromes by ..
  21. D Assante R, Fusco A, Palamaro L, Giardino G, Gallo V, Cirillo E, et al. Unraveling the Link Between Ectodermal Disorders and Primary Immunodeficiencies. Int Rev Immunol. 2016;35:25-38 pubmed publisher
    ..ED (HED), the most common form, is inherited as autosomal dominant, autosomal recessive or X-linked trait (XLHED)...
  22. DoÄŸan M, Callea M, Yavuz Ã, Aksoy O, Clarich G, Günay A, et al. An evaluation of clinical, radiological and three-dimensional dental tomography findings in ectodermal dysplasia cases. Med Oral Patol Oral Cir Bucal. 2015;20:e340-6 pubmed
    ..In the 36 cases evaluated in the study, typical clinical findings of pure hypohidrotic ectodermal displasia (HED) were seen, such as missing teeth, dry skin, hair and nail disorders...
  23. Darbinyan A, Major E, Morgello S, Holland S, Ryschkewitsch C, Monaco M, et al. BK virus encephalopathy and sclerosing vasculopathy in a patient with hypohidrotic ectodermal dysplasia and immunodeficiency. Acta Neuropathol Commun. 2016;4:73 pubmed publisher
    ..unique case of BKV-associated encephalopathy in a man with hypohidrotic ectodermal dysplasia and immunodeficiency (HED-ID) due to IKK-gamma (NEMO) mutation, who developed progressive neurological symptoms...
  24. Reyes Reali J, Mendoza Ramos M, Garrido Guerrero E, Méndez Catalá C, Méndez Cruz A, Pozo Molina G. Hypohidrotic ectodermal dysplasia: clinical and molecular review. Int J Dermatol. 2018;57:965-972 pubmed publisher
    ..This XL-HED phenotype is associated with mutations in the gene encoding the transmembrane protein ectodysplasin-1 (EDA1), a member of the TNFα-related signaling pathway...
  25. Han X, Yoshizaki K, Miyazaki K, Arai C, Funada K, Yuta T, et al. The transcription factor NKX2-3 mediates p21 expression and ectodysplasin-A signaling in the enamel knot for cusp formation in tooth development. J Biol Chem. 2018;293:14572-14584 pubmed publisher
    ..Together, our results indicate that EDA/NKX2-3 signaling is essential for enamel knot formation during tooth morphogenesis in mice. ..
  26. May A, Headon D, Rice D, Noble A, Tucker A. FGF and EDA pathways control initiation and branching of distinct subsets of developing nasal glands. Dev Biol. 2016;419:348-356 pubmed publisher
    ..This analysis helps shed light on the nasal gland defects observed in patients with hypohidrotic ectodermal dysplasia (HED) (defect EDA pathway) and LADD syndrome (defect FGFR2b pathway).
  27. Chen L, Chien Y, Liang C, Chan C, Fan M, Huang H. Green tea extract induces genes related to browning of white adipose tissue and limits weight-gain in high energy diet-fed rat. Food Nutr Res. 2017;61:1347480 pubmed publisher
    ..Four groups of rats (n=10/group) were used including a normal diet with vehicle treatment, and a high-energy diet (HED) with vehicle or GTE by oral gavage at 77.5 or 155 mg/kg/day for 8 weeks...
  28. Diwan V, Mistry A, Gobe G, Brown L. Adenine-induced chronic kidney and cardiovascular damage in rats. J Pharmacol Toxicol Methods. 2013;68:197-207 pubmed publisher
    ..stress (HO-1), fibrosis (TGF-β, α-SMA) and inflammation (TNF-α, NF-κB p52, NF-κB p50, PLA2 and ED1) were measured, along with cardiovascular parameters (blood pressure, left ventricular stiffness, vascular ..
  29. Borsari B, Magill M, Mastroleo N, Hustad J, Tevyaw T, Barnett N, et al. Mandated college students' response to sequentially administered alcohol interventions in a randomized clinical trial using stepped care. J Consult Clin Psychol. 2016;84:103-12 pubmed publisher
    ..regression model as putative predictors of lower risk drinking (defined as 3 or fewer heavy episodic drinking [HED] episodes and/or 4 or fewer alcohol-related consequences in the past month) 6 weeks following the BA session...
    ..The MDL values for a desired confidence level were also studied by three calculation methods. The results of the BGTD and the MDL studies under different conditions applied are presented and discussed. ..
  31. Haugland S, Holmen T, Krokstad S, Sund E, Bratberg G. Intergenerational Hazardous Alcohol Use and Area Factors: The HUNT Study, Norway. Subst Use Misuse. 2015;50:1753-64 pubmed publisher were to investigate whether adolescent intoxication was associated with parental heavy episodic drinking (HED) and intoxication, area-level socioeconomic status (SES), and rates of area-level HED...
  32. Lemańska Perek A, Krzyzanowska Gołab D, Pupek M, Klimeczek P, Witkiewicz W, Katnik Prastowska I. Analysis of Soluble Molecular Fibronectin-Fibrin Complexes and EDA-Fibronectin Concentration in Plasma of Patients with Atherosclerosis. Inflammation. 2016;39:1059-68 pubmed publisher
    ..The increased level of EDA-FN and occurrence of FN-fibrin complexes could have a potential diagnostic value in the diagnosis and management of patients with coronary artery disease. ..
  33. Okada K, Arai S, Itoh H, Adachi S, Hayashida M, Nakase H, et al. CD68 on rat macrophages binds tightly to S100A8 and S100A9 and helps to regulate the cells' immune functions. J Leukoc Biol. 2016;100:1093-1104 pubmed
    ..S100A8 and S100A9 were significantly suppressed after the macrophages had been treated with an anti-CD68 antibody (ED1)...
  34. Wen Y, Huang T, Huang S, Chang C, Tsai R. Early applications of granulocyte colony-stimulating factor (G-CSF) can stabilize the blood-optic-nerve barrier and ameliorate inflammation in a rat model of anterior ischemic optic neuropathy (rAION). Dis Model Mech. 2016;9:1193-1202 pubmed
    ..ON inflammation was evaluated by staining of ED1 and Iba1, and ON vascular permeability was determined by Evans Blue extravasation...
  35. Peña S, Makela P, Valdivia G, Helakorpi S, Markkula N, Margozzini P, et al. Socioeconomic inequalities in alcohol consumption in Chile and Finland. Drug Alcohol Depend. 2017;173:24-30 pubmed publisher
    ..included abstinence, weekly consumption of pure alcohol, heavy volume drinking and heavy episodic drinking (HED). We employed a novel method in alcohol research, the concentration index, to measure socioeconomic inequalities...
  36. Leyva E, Cárdenas Chaparro A, Loredo Carrillo S, López L, Méndez Sánchez F, Martínez Richa A. Ultrasound-assisted reaction of 1,4-naphthoquinone with anilines through an EDA complex. Mol Divers. 2018;22:281-290 pubmed publisher
    ..A reaction mechanism involving an EDA complex is proposed based on NMR experiments and previous studies about solid/solid reactions. ..
  37. Dhanesha N, Ahmad A, Prakash P, Doddapattar P, Lentz S, Chauhan A. Genetic Ablation of Extra Domain A of Fibronectin in Hypercholesterolemic Mice Improves Stroke Outcome by Reducing Thrombo-Inflammation. Circulation. 2015;132:2237-47 pubmed publisher
    ..These findings suggest that targeting Fn-EDA could be an effective therapeutic strategy in stroke associated with hypercholesterolemia. ..
  38. Bjerså K, Jildenstaal P, Jakobsson J, Egardt M, Fagevik Olsén M. Adjunct High Frequency Transcutaneous Electric Stimulation (TENS) for Postoperative Pain Management during Weaning from Epidural Analgesia Following Colon Surgery: Results from a Controlled Pilot Study. Pain Manag Nurs. 2015;16:944-50 pubmed publisher
    ..Further studies are warranted in order to verify the potential beneficial effects from TENS during weaning from EDA after open, lower abdominal surgery. ..
  39. Suzuki R, Takakuda K. Wound healing efficacy of a 660-nm diode laser in a rat incisional wound model. Lasers Med Sci. 2016;31:1683-1689 pubmed
    ..Tissue sections collected on postoperative day 3 were stained with hematoxylin-eosin and an antibody for ED1 to determine the number of macrophages around the wound...
  40. Qiao W, Liu L. [A gene study of a family with hidrotic ectodermal dysplasia]. Zhongguo Dang Dai Er Ke Za Zhi. 2016;18:1141-1144 pubmed
    To investigate the clinical features and molecular mechanism of hidrotic ectodermal dysplasia (HED). A clinical and gene study was performed for five generations (91 people) in the family of one proband with HED...
  41. Qin Q, Ma X, Liao X, Yang B. Scutellarin-graft cationic ?-cyclodextrin-polyrotaxane: Synthesis, characterization and DNA condensation. Mater Sci Eng C Mater Biol Appl. 2017;71:1028-1036 pubmed publisher
    ..The satisfactory pDNA condensation abilities of PR-EDA-SCU and PR-DETA-SCU could be helpful in designing non-viral gene delivery vectors to control gene expression and delivery. ..
  42. Riew T, Kim H, Choi J, Jin X, Shin Y, Lee M. Progressive accumulation of autofluorescent granules in macrophages in rat striatum after systemic 3-nitropropionic acid: a correlative light- and electron-microscopic study. Histochem Cell Biol. 2017;148:517-528 pubmed publisher
    ..In addition, immunolabeling with two lysosomal markers, ED1/CD68 and lysosomal-associated membrane protein 1, showed a pattern complementary with autofluorescent signals in ..
  43. Sharman S, Clark L. Mixed Emotions to Near-Miss Outcomes: A Psychophysiological Study with Facial Electromyography. J Gambl Stud. 2016;32:823-34 pubmed publisher
    ..The 'near-miss effect' is not a unitary phenomenon. Facial EMG has differential sensitivity to positive and negative valence and may be a useful measure for future studies of gambling behavior. ..
  44. Nathanielsz P, Yan J, Green R, Nijland M, Miller J, Wu G, et al. Maternal obesity disrupts the methionine cycle in baboon pregnancy. Physiol Rep. 2015;3: pubmed publisher
    ..To test this hypothesis, we developed a nulliparous baboon obesity model fed a high fat, high energy diet (HF-HED) prior to and during gestation, and examined methionine cycle biomarkers (e.g...
  45. Jin X, Ren S, Macarak E, Rosenbloom J. Pathobiological mechanisms of peritoneal adhesions: The mesenchymal transition of rat peritoneal mesothelial cells induced by TGF-β1 and IL-6 requires activation of Erk1/2 and Smad2 linker region phosphorylation. Matrix Biol. 2016;51:55-64 pubmed publisher
    ..In addition, the phenotypic transition could be prevented by hydrocortisone. ..
  46. Harms H, Huisman M, Rijnierse M, Greuter H, Hsieh Y, de Haan S, et al. Noninvasive Quantification of Myocardial 11C-Meta-Hydroxyephedrine Kinetics. J Nucl Med. 2016;57:1376-81 pubmed publisher
    11)C-meta-hydroxyephedrine ((11)C-HED) kinetics in the myocardium can be quantified using a single-tissue-compartment model together with a metabolite-corrected arterial blood sampler input function (BSIF)...
  47. Giromini L, Ando A, Morese R, Salatino A, Di Girolamo M, Viglione D, et al. Rorschach Performance Assessment System (R-PAS) and vulnerability to stress: A preliminary study on electrodermal activity during stress. Psychiatry Res. 2016;246:166-172 pubmed publisher
    ..Results partially confirmed our hypotheses: (a) the mean of and (b) the majority of the Stress and Distress R-PAS variables were significantly correlated, in the expected direction, with medium and medium to large effect sizes. ..
  48. Moyle P. Biotechnology approaches to produce potent, self-adjuvanting antigen-adjuvant fusion protein subunit vaccines. Biotechnol Adv. 2017;35:375-389 pubmed publisher
  49. Vijayakumar S, Prabhu S, Yabesh J, Pragashraj R. A quantitative ethnozoological study of traditionally used animals in Pachamalai hills of Tamil Nadu, India. J Ethnopharmacol. 2015;171:51-63 pubmed publisher
    ..In addition, further experimental investigations are required to elucidate the pharmacological properties of the reported medicinal fauna of Pachmalai hills. ..
  50. Liu J, Yan X, Qi L, Li L, Hu G, Li P, et al. Ginsenoside Rd attenuates Aβ25-35-induced oxidative stress and apoptosis in primary cultured hippocampal neurons. Chem Biol Interact. 2015;239:12-8 pubmed publisher
    ..These results highlighted the neuroprotective effects of GRd against Aβ25-35-induced oxidative stress and neuronal apoptosis, suggesting that this may be a promising therapeutics against AD. ..
  51. Tan Z, Chen Y, Zhao H, Zhao H, Zhao A, Zhao Z, et al. [Differential expression profile of microRNAs between human bone marrow mesenchymal stem cells and sweat gland-like cells]. Zhonghua Yi Xue Za Zhi. 2015;95:2626-9 pubmed
    ..And 13 miRNAs >5 folds of differential expression and 18 miRNAs related to sweat gland development may play essential roles in regulated differentiation of hBM-MSCs into sweat gland-like cells. ..
  52. Fakhraee S, Souri M. Double hydrogen bond interaction in 7-azaindole complexes with protic solvents. J Mol Graph Model. 2016;70:45-53 pubmed publisher
    ..Finally, the double hydrogen bond between 7AI and FA is identified as dominant interaction to achieve the tautomerization of 7AI in all applied approaches. ..
  53. Elo T, Lindfors P, Lan Q, Voutilainen M, Trela E, Ohlsson C, et al. Ectodysplasin target gene Fgf20 regulates mammary bud growth and ductal invasion and branching during puberty. Sci Rep. 2017;7:5049 pubmed publisher
    ..These findings identify a hitherto unknown function for Fgf20 in mammary budding and branching morphogenesis. ..
  54. Ortolan A, Caramori G, Matthias Bickelhaupt F, Parreira R, Muñoz Castro A, Kar T. How the electron-deficient cavity of heterocalixarenes recognizes anions: insights from computation. Phys Chem Chem Phys. 2017;19:24696-24705 pubmed publisher
    ..Electrostatic interactions appear to be dominant for heterocalixarenes with oxygen bridges whereas orbital interactions prevail in the case of nitrogen and sulfur bridges. Dispersion interactions are however in all cases non-negligible. ..
  55. Li H, Wang Y, Zheng H. Variations of moisture and organics in activated sludge during Fe0/S2O82- conditioning-horizontal electro-dewatering process. Water Res. 2018;129:83-93 pubmed publisher
    ..conditioning (zero valence iron (ZVI)/persulfate (ps)) integrated with horizontal electro-dewatering (HED) to improve the dewaterability of activated sludge (AS) was evaluated...
  56. Schubert M, Schmidt M, Wolter P, Malberg H, Zaunseder S, Bock K. Additively Manufactured Pneumatically Driven Skin Electrodes. Materials (Basel). 2017;11: pubmed publisher
    ..The results show less amplitude compared to conventional EDA electrodes but similar behavior. Because of the manufacturing process the module enables high individuality for future applications. ..
  57. Barczuk FalÄ™cka M, MaÅ‚ek Å, Roik D, Werys K, Werner B, Brzewski M. Right ventricular end-systolic area as a simple first-line marker predicting right ventricular enlargement and decreased systolic function in children referred for cardiac magnetic resonance imaging. Clin Radiol. 2018;73:592.e9-592.e14 pubmed publisher
    ..873, p<0.001, sensitivity 83%, specificity 89%). For routine screening in clinical practice, 4CH ESA seems a reliable and easy method to identify patients with RV dysfunction. ..
  58. Palumbo F, Bavuso Volpe A, Bongiovì F, Pitarresi G, Giammona G. A New Hyaluronic Acid Derivative Obtained from Atom Transfer Radical Polymerization as a siRNA Vector for CD44 Receptor Tumor Targeting. Macromol Biosci. 2015;15:1605-15 pubmed publisher
    ..In vitro studies performed on HCT 116 cell line, that over express CD44 receptor, demonstrate a receptor mediated uptake of complexes, regardless of their surface charge. ..
  59. Lanza S, Vasilenko S, Dziak J, Butera N. Trends Among U.S. High School Seniors in Recent Marijuana Use and Associations With Other Substances: 1976-2013. J Adolesc Health. 2015;57:198-204 pubmed publisher
    ..Future (1976-2013; N = 599,109) were used to estimate historical trends in alcohol use, heavy episodic drinking (HED), cigarette use, and marijuana use...
  60. Kreimeyer R, Ludwig S. Automatic Classification of Marine Mammals with Speaker Classification Methods. Adv Exp Med Biol. 2016;875:573-81 pubmed publisher
    ..The automatic classification should support sonar operators in the risk mitigation process before and during sonar exercises with a reliable automatic classification result. ..
  61. Sundbeck M, Emmelin A, Mannheimer L, Miörner H, Agardh A. Sexual risk-taking during travel abroad - a cross-sectional survey among youth in Sweden. Travel Med Infect Dis. 2016;14:233-41 pubmed publisher
    ..socio-demographic background, life-style, travel duration, sexuality, mental health, heavy episodic drinking (HED) and drug-use. Approximately 1/4 reported intercourse with a casual partner abroad...
  62. Wang H, Yang Z, Du S, Ma L, Liao Y, Wang Y, et al. Characterization of Pectobacterium carotovorum proteins differentially expressed during infection of Zantedeschia elliotiana in vivo and in vitro which are essential for virulence. Mol Plant Pathol. 2018;19:35-48 pubmed publisher
    ..The results highlight the value of undertaking in vivo as well as in vitro approaches for the identification of new bacterial virulence factors. ..
  63. Lu L, Wang J, Chen B. Adsorption and desorption of phthalic acid esters on graphene oxide and reduced graphene oxide as affected by humic acid. Environ Pollut. 2018;232:505-513 pubmed publisher
    ..The desorption of DMP and DEP on RGO in presence of HA was quick and enhanced. These results should be important for evaluating the fate and health risk of graphene materials and PAEs in the environment. ..
  64. Brandstaedter C, Fritz Wolf K, Weder S, Fischer M, Hecker B, Rahlfs S, et al. Kinetic characterisation of wild type and mutant human thioredoxin glutathione reductase defines its reaction and regulatory mechanisms. FEBS J. 2017;: pubmed publisher
    ..All four proteins were kinetically characterized in direct comparison using Trx, DTNB, HED or GSSG as oxidizing substrate...
  65. Trzeciak W, Koczorowski R. Molecular basis of hypohidrotic ectodermal dysplasia: an update. J Appl Genet. 2016;57:51-61 pubmed publisher
    Recent advances in understanding the molecular events underlying hypohidrotic ectodermal dysplasia (HED) caused by mutations of the genes encoding proteins of the tumor necrosis factor α (TNFα)-related signaling pathway have been ..
  66. Medina E, Romero Gil V, Garrido Fernandez A, Arroyo López F. Survival of foodborne pathogens in natural cracked olive brines. Food Microbiol. 2016;59:104-11 pubmed publisher
    ..Results confirm the adverse habitats of table olives for foodborne pathogenic microorganisms. ..
  67. Mondal T, De S, Maity B, Koley D. Exploring the Oxidative-Addition Pathways of Phenyl Chloride in the Presence of PdII Abnormal N-Heterocyclic Carbene Complexes: A DFT Study. Chemistry. 2016;22:15778-15790 pubmed publisher
    ..5?kcal?mol-1 (?GLS-D3 ). To further elucidate the origin of transition-state barriers, EDA calculations were performed for some key saddle points populating the energy profiles. ..
  68. Menacer R, May A, Belkhiri L, Mousser A. Electronic structure and bonding of the dinuclear metal M2(CO)10 decacarbonyls: applications of natural orbitals for chemical valence. J Mol Model. 2017;23:358 pubmed publisher
  69. Younan D, Griffin R, Reiff D, Richey J, Schinnerer E, Pittet J, et al. Echocardiographic correlates are associated with in-hospital mortality in trauma and burn patients. Am J Surg. 2017;214:798-803 pubmed publisher
    ..Abnormal EDA was associated with in-hospital death (OR 4.20, 95% CI 1.45-12.17). Echocardiographic measurements can predict outcome in trauma and burn patients. Further studies are needed to confirm these findings. ..
  70. Wang F, Islam S, Vasilyev V. Ferrocene Orientation Determined Intramolecular Interactions Using Energy Decomposition Analysis. Materials (Basel). 2015;8:7723-7737 pubmed publisher
    ..6 kcal·mol-1. ..
  71. Kelsh Lasher R, Ambesi A, Bertram C, McKeown Longo P. Integrin α4β1 and TLR4 Cooperate to Induce Fibrotic Gene Expression in Response to Fibronectin's EDA Domain. J Invest Dermatol. 2017;137:2505-2512 pubmed publisher
    ..The data suggest a paradigm of damage-associated molecular pattern-based signaling whereby damage-associated molecular pattern binding integrins cooperate with innate immune receptors to stimulate inflammation and fibrosis. ..
  72. Zhou H, Zhang H, Yan Z, Xu R. Transplantation of human amniotic mesenchymal stem cells promotes neurological recovery in an intracerebral hemorrhage rat model. Biochem Biophys Res Commun. 2016;475:202-8 pubmed publisher
    ..and the PBS control, hAMSCs treatment significantly promoted neurological recovery, and reduced the numbers of ED1(+) activated microglia, as well as myeloperoxidase (MPO(+)), and caspase-3(+) cells in the brain injury model...
  73. Montonen O, Ezer S, Saarialho Kere U, Herva R, Karjalainen Lindsberg M, Kaitila I, et al. The gene defective in anhidrotic ectodermal dysplasia is expressed in the developing epithelium, neuroectoderm, thymus, and bone. J Histochem Cytochem. 1998;46:281-9 pubmed
    ..However, the expression is not limited to the ectodermal tissues and many sites of expression are not obviously reflected in the clinical features of the syndrome. ..
  74. Ruiz Heiland G, Jabir S, Wende W, Blecher S, Bock N, Ruf S. Novel missense mutation in the EDA gene in a family affected by oligodontia. J Orofac Orthop. 2016;77:31-8 pubmed publisher
    ..Arg289His in EDA impairs protein stabilization and thus might possibly be involved in the development of oligodontia concomitant with a mild ED phenotype. ..
  75. Wu Q, Shi H, Liu B, Zhao Z, Jiang M, Lu N, et al. [Detection of ED1 gene mutations in six pedigrees with hypohidrotic ectodermal dysplasia]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2012;29:447-51 pubmed publisher
    To identify potential mutations of ED1 gene in six pedigrees with hypohidrotic ectodermal dysplasia (HED), and to provide genetic counseling and prenatal diagnosis...
  76. Muschket M, Di Paolo C, Tindall A, Touak G, Phan A, Krauss M, et al. Identification of Unknown Antiandrogenic Compounds in Surface Waters by Effect-Directed Analysis (EDA) Using a Parallel Fractionation Approach. Environ Sci Technol. 2017;: pubmed publisher
    ..This is of some concern since C47 is used in a number of consumer products indicating environmental as well as human exposure...
  77. Martinez F, Millan J, Orellana C, Prieto F. X-linked anhidrotic (hypohidrotic) ectodermal dysplasia caused by a novel mutation in EDA1 gene: 406T > G (Leu55Arg). J Invest Dermatol. 1999;113:285-6 pubmed
  78. You J, Li H. Improving the accuracy of effect-directed analysis: the role of bioavailability. Environ Sci Process Impacts. 2017;19:1484-1498 pubmed publisher
    ..Lastly, the future perspectives of expanding and standardizing the use of biological samples and bioavailability-based techniques in EDA are discussed. ..
  79. Ayub M, Ur Rehman F, Yasinzai M, Ahmad W. A novel missense mutation in the ectodysplasin-A (EDA) gene underlies X-linked recessive nonsyndromic hypodontia. Int J Dermatol. 2010;49:1399-402 pubmed publisher
    ..Recent studies in a few families showed that mutations in the ectodysplasin A (EDA) gene result in X-linked nonsyndromic hypodontia...
  80. Martins Santos E, Pimenta C, Campos P, Franco M, Gomes D, Mahecha G, et al. Persistent testicular structural and functional alterations after exposure of adult rats to atrazine. Reprod Toxicol. 2017;73:201-213 pubmed publisher
    ..Moreover, there was increase in ED1-/ED2+, ED1+/ED2+ and ED1+/ED2- macrophages, in ..
  81. Azeem Z, Naqvi S, Ansar M, Wali A, Naveed A, Ali G, et al. Recurrent mutations in functionally-related EDA and EDAR genes underlie X-linked isolated hypodontia and autosomal recessive hypohidrotic ectodermal dysplasia. Arch Dermatol Res. 2009;301:625-9 pubmed publisher
    ..functionally related genes EDA, EDAR and EDARDD have been reported to cause hypohidrotic ectodermal dysplasia (HED), which is characterized by sparse hair, reduced ability to sweat, and hypodontia...
  82. Liu Y, Yu X, Wang L, Li C, Archacki S, Huang C, et al. Mutation p.Leu354Pro in EDA causes severe hypohidrotic ectodermal dysplasia in a Chinese family. Gene. 2012;491:246-50 pubmed publisher
    X-linked recessive hypohidrotic ectodermal dysplasia (XLHED) is characterized by the defective morphogenesis of teeth, hair, and eccrine sweat glands. It is associated with mutations in the EDA gene...
  83. Visnovcova Z, Mestanik M, Gala M, Mestanikova A, Tonhajzerova I. The complexity of electrodermal activity is altered in mental cognitive stressors. Comput Biol Med. 2016;79:123-129 pubmed publisher
    ..Detailed knowledge of EDA regulatory mechanisms associated with stress could provide important information associated with autonomic dysregulation. ..
  84. Vines T, Dalziel A, Albert A, Veen T, Schulte P, Schluter D. Cline coupling and uncoupling in a stickleback hybrid zone. Evolution. 2016;70:1023-38 pubmed publisher
    ..It thus remains possible that these clines cluster together because their individual selection regimes are identical, but this would be very surprising given their diverse roles in osmoregulation, body armor, and swimming performance. ..
  85. Yang X, Yang F, Wu R, Yan C, Zhou D, Zhou P, et al. Linear σ-hole⋯CO⋯σ-hole intermolecular interactions between carbon monoxide and dihalogen molecules XY (X, Y=Cl, Br). J Mol Graph Model. 2017;76:419-428 pubmed publisher
    ..The results would provide valuable insight into for these linear halogen bonds. ..
  86. Srivastava A, Montonen O, Saarialho Kere U, Chen E, Baybayan P, Pispa J, et al. Fine mapping of the EDA gene: a translocation breakpoint is associated with a CpG island that is transcribed. Am J Hum Genet. 1996;58:126-32 pubmed
    ..The two most telomeric CpG islands map 350 kb telomeric of the two translocations. Taken together, the results suggest that the CpG island just proximal of the AK translocation breakpoint lies at the 5' end of a candidate gene for EDA. ..
  87. Bracco M, Turriziani P, Smirni D, Mangano R, Oliveri M. Relationship between physiological excitatory and inhibitory measures of excitability in the left vs. right human motor cortex and peripheral electrodermal activity. Neurosci Lett. 2017;641:45-50 pubmed publisher
    ..These findings may suggest a bi-hemispheric mode of control of vegetative system by motor cortices, with the right hemisphere mainly involved in sympathetic control. ..
  88. Zhang H, Quan C, Sun L, Lv H, Gao M, Zhou F, et al. A novel frameshift mutation of the EDA1 gene in a Chinese Han family with X-linked hypohidrotic ectodermal dysplasia. Clin Exp Dermatol. 2009;34:74-6 pubmed publisher
    ..HED can be autosomal dominant, autosomal recessive or X-linked. However, X-linked HED (XLHED; OMIM 305100) is the most common form...
  89. Zavgorodnya O, Carmona Moran C, Kozlovskaya V, Liu F, Wick T, Kharlampieva E. Temperature-responsive nanogel multilayers of poly(N-vinylcaprolactam) for topical drug delivery. J Colloid Interface Sci. 2017;506:589-602 pubmed publisher
    ..Our study provides opportunity for development of temperature-responsive multilayer hydrogel coatings made via the assembly of core-shell nanogel particles which can be used for skin-sensitive materials for topical drug delivery. ..
  90. Fuentes E, Paucar F, Tapia F, Ortiz J, Jimenez P, Romero N. Effect of the composition of extra virgin olive oils on the differentiation and antioxidant capacities of twelve monovarietals. Food Chem. 2018;243:285-294 pubmed publisher
    ..Validation of the model gave a correlation R>0.83 and an error of 7% for independent samples. This model could be a useful tool for the olive industry to highlight the nutritional quality of EVOOs and improve their marketing. ..
  91. Schneider H, Hammersen J, Preisler Adams S, Huttner K, Rascher W, Bohring A. Sweating ability and genotype in individuals with X-linked hypohidrotic ectodermal dysplasia. J Med Genet. 2011;48:426-32 pubmed publisher
    X-linked hypohidrotic ectodermal dysplasia (XLHED), the most common type of ectodermal dysplasia, is caused by EDA gene mutations. Reduced sweating contributes substantially to XLHED associated morbidity and mortality...
  92. Shen W, Wang Y, Liu Y, Liu H, Zhao H, Zhang G, et al. Functional Study of Ectodysplasin-A Mutations Causing Non-Syndromic Tooth Agenesis. PLoS ONE. 2016;11:e0154884 pubmed publisher
    ..The receptor binding capability of the mutant EDA1 protein was impaired in comparison to wild-type EDA1...