Gene Symbol: ECHDC3
Description: enoyl-CoA hydratase domain containing 3
Alias: enoyl-CoA hydratase domain-containing protein 3, mitochondrial, enoyl Coenzyme A hydratase domain containing 3, testis tissue sperm-binding protein Li 76m
Sharma N, Chuang Key C, Civelek M, Wabitsch M, Comeau M, Langefeld C, et al
. Genetic Regulation of enoyl-CoA hydratase Domain-Containing 3 in Adipose Tissue Determines Insulin Sensitivity in African Americans and Europeans. Diabetes. 2019;: pubmed publisher
..The enoyl-CoA hydratase domain-containing 3 (ECHDC3) was the top ranked Matsuda index-correlated cis-eGene...
Yin J, Feng W, Yuan H, Yuan J, Wu Y, Liu X, et al
. Association analysis of polymorphisms in STARD6 and near ECHDC3 in Alzheimer's disease patients carrying the APOE ε4 Allele. Neuropsychiatr Dis Treat. 2019;15:213-218 pubmed publisher
..lipid transfer domain 6 (STARD6) and near the enzyme enoyl CoA hydratase domain containing 3 (ECHDC3) gene are related to plasma lipid levels or lipid traits in AD...
Witoelar A, Rongve A, Almdahl I, Ulstein I, Engvig A, White L, et al
. Meta-analysis of Alzheimer's disease on 9,751 samples from Norway and IGAP study identifies four risk loci. Sci Rep. 2018;8:18088 pubmed publisher
..We also associated USP6NL/ECHDC3 and BZRAP1-AS1 to AD, confirming findings from a follow-up transethnic study...
Tesi N, van der Lee S, Hulsman M, Jansen I, Stringa N, van Schoor N, et al
. Centenarian controls increase variant effect sizes by an average twofold in an extreme case-extreme control analysis of Alzheimer's disease. Eur J Hum Genet. 2019;27:244-253 pubmed publisher
..5-fold), and significant for variants in/near ECHDC3 (4.6-fold), SLC24A4-RIN3 (4.5-fold), NME8 (3.8-fold), PLCG2 (3.3-fold), APOE-ε2 (2...
Desikan R, Schork A, Wang Y, Thompson W, Dehghan A, Ridker P, et al
. Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease. Circulation. 2015;131:2061-2069 pubmed publisher
..07; 95% confidence interval=1.05-1.11; P=2.86Ã—10(-8)) and chromosome 10 (rs7920721; closest gene, ECHDC3; odds ratio=1.07; 95% confidence interval=1.04-1.11; P=3.38Ã—10(-8))...
Duarte M, de Araújo J, Duarte V, de Oliveira K, de Oliveira J, Carioca A, et al
. The relationship of the oleic acid level and ECHDC3 mRNA expression with the extent of coronary lesion. Lipids Health Dis. 2016;15:144 pubmed publisher
..We previously reported a correlation between ECHDC3 upregulation and the severity of acute coronary syndrome...
Jun G, Chung J, Mez J, Barber R, Beecham G, Bennett D, et al
. Transethnic genome-wide scan identifies novel Alzheimer's disease loci. Alzheimers Dement. 2017;13:727-738 pubmed publisher
..polymorphism (SNP)-based tests (P < 5 × 10-8) were identified for SNPs in PFDN1/HBEGF, USP6NL/ECHDC3, and BZRAP1-AS1 and for the interaction of the (apolipoprotein E) APOE ε4 allele with NFIC SNP...
Watson C, Cohain A, Griffin R, Chun Y, Grishin A, Hacyznska H, et al
. Integrative transcriptomic analysis reveals key drivers of acute peanut allergic reactions. Nat Commun. 2017;8:1943 pubmed publisher
..Key driver analysis identifies six genes (LTB4R, PADI4, IL1R2, PPP1R3D, KLHL2, and ECHDC3) predicted to causally modulate the state of coregulated networks in response to peanut...