ECHDC3

Summary

Gene Symbol: ECHDC3
Description: enoyl-CoA hydratase domain containing 3
Alias: enoyl-CoA hydratase domain-containing protein 3, mitochondrial, enoyl Coenzyme A hydratase domain containing 3, testis tissue sperm-binding protein Li 76m
Species: human
Products:     ECHDC3

Top Publications

  1. Sharma N, Chuang Key C, Civelek M, Wabitsch M, Comeau M, Langefeld C, et al. Genetic Regulation of enoyl-CoA hydratase Domain-Containing 3 in Adipose Tissue Determines Insulin Sensitivity in African Americans and Europeans. Diabetes. 2019;: pubmed publisher
    ..The enoyl-CoA hydratase domain-containing 3 (ECHDC3) was the top ranked Matsuda index-correlated cis-eGene...
  2. Yin J, Feng W, Yuan H, Yuan J, Wu Y, Liu X, et al. Association analysis of polymorphisms in STARD6 and near ECHDC3 in Alzheimer's disease patients carrying the APOE ε4 Allele. Neuropsychiatr Dis Treat. 2019;15:213-218 pubmed publisher
    ..lipid transfer domain 6 (STARD6) and near the enzyme enoyl CoA hydratase domain containing 3 (ECHDC3) gene are related to plasma lipid levels or lipid traits in AD...
  3. Witoelar A, Rongve A, Almdahl I, Ulstein I, Engvig A, White L, et al. Meta-analysis of Alzheimer's disease on 9,751 samples from Norway and IGAP study identifies four risk loci. Sci Rep. 2018;8:18088 pubmed publisher
    ..We also associated USP6NL/ECHDC3 and BZRAP1-AS1 to AD, confirming findings from a follow-up transethnic study...
  4. Tesi N, van der Lee S, Hulsman M, Jansen I, Stringa N, van Schoor N, et al. Centenarian controls increase variant effect sizes by an average twofold in an extreme case-extreme control analysis of Alzheimer's disease. Eur J Hum Genet. 2019;27:244-253 pubmed publisher
    ..5-fold), and significant for variants in/near ECHDC3 (4.6-fold), SLC24A4-RIN3 (4.5-fold), NME8 (3.8-fold), PLCG2 (3.3-fold), APOE-ε2 (2...
  5. Desikan R, Schork A, Wang Y, Thompson W, Dehghan A, Ridker P, et al. Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease. Circulation. 2015;131:2061-2069 pubmed publisher
    ..07; 95% confidence interval=1.05-1.11; P=2.86×10(-8)) and chromosome 10 (rs7920721; closest gene, ECHDC3; odds ratio=1.07; 95% confidence interval=1.04-1.11; P=3.38×10(-8))...
  6. Duarte M, de Araújo J, Duarte V, de Oliveira K, de Oliveira J, Carioca A, et al. The relationship of the oleic acid level and ECHDC3 mRNA expression with the extent of coronary lesion. Lipids Health Dis. 2016;15:144 pubmed publisher
    ..We previously reported a correlation between ECHDC3 upregulation and the severity of acute coronary syndrome...
  7. Jun G, Chung J, Mez J, Barber R, Beecham G, Bennett D, et al. Transethnic genome-wide scan identifies novel Alzheimer's disease loci. Alzheimers Dement. 2017;13:727-738 pubmed publisher
    ..polymorphism (SNP)-based tests (P < 5 × 10-8) were identified for SNPs in PFDN1/HBEGF, USP6NL/ECHDC3, and BZRAP1-AS1 and for the interaction of the (apolipoprotein E) APOE ε4 allele with NFIC SNP...
  8. Watson C, Cohain A, Griffin R, Chun Y, Grishin A, Hacyznska H, et al. Integrative transcriptomic analysis reveals key drivers of acute peanut allergic reactions. Nat Commun. 2017;8:1943 pubmed publisher
    ..Key driver analysis identifies six genes (LTB4R, PADI4, IL1R2, PPP1R3D, KLHL2, and ECHDC3) predicted to causally modulate the state of coregulated networks in response to peanut...