EBI3

Summary

Gene Symbol: EBI3
Description: Epstein-Barr virus induced 3
Alias: IL-27B, IL27B, EBV-induced gene 3 protein, Epstein-Barr virus induced gene 3, IL-27 subunit beta, IL27 subunit, IL35 subunit, cytokine receptor, epstein-Barr virus-induced gene 3 protein, interleukin-27 subunit beta
Species: human

Top Publications

  1. ncbi Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin
    O Devergne
    Department of Medicine, Harvard Medical School and Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 94:12041-6. 1997
  2. ncbi A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes
    O Devergne
    Department of Microbiology and Molecular Genetics, Harvard University, Boston, Massachusetts, USA
    J Virol 70:1143-53. 1996
  3. ncbi Hepatocyte growth factor/scatter factor in the eye
    I Grierson
    Unit of Ophthalmology, Department of Medicine, University of Liverpool, Duncan Building, L69 3GA, Liverpool, UK
    Prog Retin Eye Res 19:779-802. 2000
  4. ncbi Interleukin-1-induced ether-linked diglycerides inhibit calcium-insensitive protein kinase C isotypes. Implications for growth senescence
    A Mandal
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106-4949, USA
    J Biol Chem 272:20306-11. 1997
  5. ncbi Hybrid tyrosine kinase/cytokine receptors transmit mitogenic signals in response to ligand
    R E Pacifici
    Department of Molecular Biology, Amgen Inc, Amgen Center, Thousand Oaks, California 91320
    J Biol Chem 269:1571-4. 1994
  6. ncbi Cytokine and cytokine receptor serum levels in adult bone sarcoma patients: correlations with local tumor extent and prognosis
    Piotr Rutkowski
    Department of Soft Tissue Bone Sarcomas, M Sklodowska Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
    J Surg Oncol 84:151-9. 2003
  7. ncbi Cytokine receptor signal transduction mechanisms in immuno-hematopoietic cells
    V Chiarugi
    Laboratory of Molecular Biology, University of Florence
    Tumori 79:92-9. 1993
  8. ncbi Characterization of the murine Mpl proto-oncogene, a member of the hematopoietic cytokine receptor family: molecular cloning, chromosomal location and evidence for a function in cell growth
    I Vigon
    INSERM U363, ICGM, Hopital Cochin, Paris, France
    Oncogene 8:2607-15. 1993
  9. ncbi MAPPIT: a cytokine receptor-based two-hybrid method in mammalian cells
    J Tavernier
    VIB09 Department of Medical Protein Research, Faculty of Medicine and Health Sciences, Department of Biochemistry, Ghent University, Ghent Belgium
    Clin Exp Allergy 32:1397-404. 2002
  10. ncbi The murine interleukin-3 receptor alpha subunit gene: chromosomal localization, genomic structure, and promoter function
    I Miyajima
    DNAX Research Institute of Molecular and Cellular Biology, Palo Alto
    Blood 85:1246-53. 1995

Research Grants

  1. Il-7 receptor signaling in lymphopoiesis
    Motonari Kondo; Fiscal Year: 2009
  2. GI Nematodes and Gut Functional Responses to Inflammation
    Terez Shea Donohue; Fiscal Year: 2011
  3. GI Nematodes and Gut Functional Responses to Inflammation
    Terez Shea Donohue; Fiscal Year: 2009
  4. GI Nematodes and Gut Functional Responses to Inflammation
    Terez Shea Donohue; Fiscal Year: 2010
  5. Phase II, IL-1 Trap for Treatment of Familial Mediterranean Fever
    Steven J Spalding; Fiscal Year: 2010
  6. Phase II, IL-1 Trap for Treatment of Familial Mediterranean Fever
    PHILLIP HASHKES; Fiscal Year: 2007
  7. Identification of Biofilm-Induced Staphylococcus aureus Cytokine Receptors
    ARLENE HOOGEWERF; Fiscal Year: 2006
  8. Anti-Apoptotic Signaling by the IL-2/15 Receptor
    SARAH GAFFEN; Fiscal Year: 2006
  9. INTERLEUKIN 4 REGULATION OF LYMPHOCYTES
    Mark R Boothby; Fiscal Year: 2010
  10. INTERLEUKIN 4 REGULATION OF LYMPHOCYTES
    Mark Boothby; Fiscal Year: 2004

Detail Information

Publications132 found, 100 shown here

  1. ncbi Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin
    O Devergne
    Department of Medicine, Harvard Medical School and Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 94:12041-6. 1997
    The Epstein-Barr virus-induced gene 3 (EBI3) is a novel soluble hematopoietin component related to the p40 subunit of interleukin 12 (IL-12)...
  2. ncbi A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes
    O Devergne
    Department of Microbiology and Molecular Genetics, Harvard University, Boston, Massachusetts, USA
    J Virol 70:1143-53. 1996
    ..EBI3 maps to chromosome 19p13.2/3, near genes encoding the erythropoietin receptor and the cytokine receptor-associated kinase, Tyk2...
  3. ncbi Hepatocyte growth factor/scatter factor in the eye
    I Grierson
    Unit of Ophthalmology, Department of Medicine, University of Liverpool, Duncan Building, L69 3GA, Liverpool, UK
    Prog Retin Eye Res 19:779-802. 2000
    ..Finally HGF/SF may be involved in the metastatic spread of tumour cells from uveal melanomata and in the formation of vascular channels in these tumours...
  4. ncbi Interleukin-1-induced ether-linked diglycerides inhibit calcium-insensitive protein kinase C isotypes. Implications for growth senescence
    A Mandal
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106-4949, USA
    J Biol Chem 272:20306-11. 1997
    ..This signaling mechanism implicates cytokine receptor-induced ether-linked diglycerides as second messengers that inhibit the bioactivity of calcium-insensitive ..
  5. ncbi Hybrid tyrosine kinase/cytokine receptors transmit mitogenic signals in response to ligand
    R E Pacifici
    Department of Molecular Biology, Amgen Inc, Amgen Center, Thousand Oaks, California 91320
    J Biol Chem 269:1571-4. 1994
    ..mitogenic signal transduction, much less is known about such mechanisms for members of the hematopoietic cytokine receptor family...
  6. ncbi Cytokine and cytokine receptor serum levels in adult bone sarcoma patients: correlations with local tumor extent and prognosis
    Piotr Rutkowski
    Department of Soft Tissue Bone Sarcomas, M Sklodowska Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
    J Surg Oncol 84:151-9. 2003
    ....
  7. ncbi Cytokine receptor signal transduction mechanisms in immuno-hematopoietic cells
    V Chiarugi
    Laboratory of Molecular Biology, University of Florence
    Tumori 79:92-9. 1993
    Novel aspects of cytokine receptor signal transduction are discussed and cytokine receptors classified based on ligand-dependent signalling. An introductory section presents an overview of the role of cytokines in hematopoiesis...
  8. ncbi Characterization of the murine Mpl proto-oncogene, a member of the hematopoietic cytokine receptor family: molecular cloning, chromosomal location and evidence for a function in cell growth
    I Vigon
    INSERM U363, ICGM, Hopital Cochin, Paris, France
    Oncogene 8:2607-15. 1993
    ..leukemia virus (MPLV) encodes a truncated form of a putative receptor protein that belongs to the cytokine receptor superfamily. We previously reported the cloning of complete human c-MPL cDNA...
  9. ncbi MAPPIT: a cytokine receptor-based two-hybrid method in mammalian cells
    J Tavernier
    VIB09 Department of Medical Protein Research, Faculty of Medicine and Health Sciences, Department of Biochemistry, Ghent University, Ghent Belgium
    Clin Exp Allergy 32:1397-404. 2002
    ....
  10. ncbi The murine interleukin-3 receptor alpha subunit gene: chromosomal localization, genomic structure, and promoter function
    I Miyajima
    DNAX Research Institute of Molecular and Cellular Biology, Palo Alto
    Blood 85:1246-53. 1995
    The interleukin-3 receptor (IL-3R) is composed of alpha and beta subunits, members of the class I cytokine receptor family...
  11. ncbi Associations between cytokine/cytokine receptor single nucleotide polymorphisms and humoral immunity to measles, mumps and rubella in a Somali population
    N Dhiman
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Tissue Antigens 72:211-20. 2008
    We genotyped a Somali population (n = 85; age < or =30 years) for 617 cytokine and cytokine receptor single nucleotide polymorphisms (SNPs) using Illumina GoldenGate genotyping to determine associations with measles, mumps and rubella ..
  12. ncbi Cancer chemoprevention by tea polyphenols through modulating signal transduction pathways
    Jen Kun Lin
    Institute of Biochemistry, College of Medicine, National Taiwan University, Taipei
    Arch Pharm Res 25:561-71. 2002
    ..The suppression of various tumor biomarkers including growth factor receptor tyrosine kinases, cytokine receptor kinases, PI3K, phosphatases, ras, raf, MAPK cascades, N x FB, I x B kinase, PKA, PKB, PKC, c-jun, c-fos, c-..
  13. ncbi A role for leptin and its cognate receptor in hematopoiesis
    B D Bennett
    Department of Molecular Oncology, Genentech Inc, 460 Point San Bruno Blvd, South San Francisco, California 94080, USA
    Curr Biol 6:1170-80. 1996
    ..In this study, we have undertaken a search for novel cytokines that may influence the fate of hematopoietic stem cells...
  14. ncbi Prolactin modulates phosphorylation, signaling and trafficking of epidermal growth factor receptor in human T47D breast cancer cells
    Y Huang
    Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Alabama at Birmingham, Birmingham, AL 35294 0012, USA
    Oncogene 25:7565-76. 2006
    ..lactation and other biological effects by interacting with the PRL receptor, a Janus kinase (JAK)2-coupled cytokine receptor family member, and activating downstream signal pathways...
  15. ncbi Tocilizumab: an interleukin-6 receptor inhibitor for the treatment of rheumatoid arthritis
    Susyn L Plushner
    Clinical Pharmacy Specialist in Rheumatology and Therapeutic Initiatives, 2045 Franklin St, Denver, CO 80205, USA
    Ann Pharmacother 42:1660-8. 2008
    To review the pharmacology, pharmacokinetics, clinical trial data, and safety profile of tocilizumab, a new biologic agent targeting the interleukin-6 cytokine receptor.
  16. ncbi Preclinical results of sirolimus treatment in transplant models
    S M Stepkowski
    Division of Immunology and Organ Transplantation, Department of Surgery, The University of Texas Medical School at Houston, Houston, Texas 77030, USA
    Transplant Proc 35:219S-226S. 2003
    ..Signal 3 (cytokine/cytokine receptor) initiate cell division and differentiation in the late G(1)/S phase...
  17. ncbi Heterogeneous expression of interleukin-18 and its receptor in B-cell lymphoproliferative disorders deriving from naive, germinal center, and memory B lymphocytes
    Irma Airoldi
    Laboratories of Oncology and Pathology, G Gaslini Institute, Genoa, Italy, and Laboratory of Pathology, St Andrea Hospital, La Spezia, Italy
    Clin Cancer Res 10:144-54. 2004
    Dysregulated cytokine/cytokine receptor expression may occur in B-cell lymphoproliferative disorders. Little information is available on interleukin-18 receptor (IL-18R) and IL-18 expression in normal and malignant B cells...
  18. ncbi Growth hormone and prolactin stimulate tyrosine phosphorylation of insulin receptor substrate-1, -2, and -3, their association with p85 phosphatidylinositol 3-kinase (PI3-kinase), and concomitantly PI3-kinase activation via JAK2 kinase
    T Yamauchi
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo 113, Japan
    J Biol Chem 273:15719-26. 1998
    Growth hormone (GH) and prolactin (PRL) binding to their receptors, which belong to the cytokine receptor superfamily, activate Janus kinase (JAK) 2 tyrosine kinase, thereby leading to their biological actions...
  19. ncbi Determinants of growth hormone receptor down-regulation
    Luqin Deng
    Department of Cell Biology, Division of Endocrinology, Diabetes, and Metabolism, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
    Mol Endocrinol 21:1537-51. 2007
    GH receptor (GHR) is a cytokine receptor family member that responds to GH by activation of the receptor-associated tyrosine kinase, JAK2 (Janus family of tyrosine kinase 2)...
  20. ncbi The essential role of p53 in hyperpigmentation of the skin via regulation of paracrine melanogenic cytokine receptor signaling
    Daiki Murase
    Kao Biological Science Laboratories, Haga, Tochigi 321 3497, Japan
    J Biol Chem 284:4343-53. 2009
    ..including sun exposure, inflammation, and aging, this finding led us to examine the involvement of p53 in cytokine receptor signaling, which might result in skin hyperpigmentation...
  21. ncbi Signal transduction for interleukin-3-dependent leukotriene synthesis in normal human basophils: opposing role of tyrosine kinase and protein kinase
    M Krieger
    Institute of Clinical Immunology, Inselspital, Bern, Switzerland
    Eur J Immunol 22:2907-13. 1992
    ..In addition, the signal transduction mechanisms utilized by the cytokine receptor family are still poorly understood...
  22. ncbi Endogenous ciliary neurotrophic factor protects GABAergic, but not cholinergic, septohippocampal neurons following fimbria-fornix transection
    Thomas Naumann
    Institute of Anatomy, University of Freiburg, Germany
    Brain Pathol 13:309-21. 2003
    ..In addition, we studied the cellular expression of CNTF, LIF and related cytokine receptor components in the septal complex following lesion...
  23. ncbi Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding
    F C Stomski
    Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, South Australia
    Mol Cell Biol 16:3035-46. 1996
    ..These receptors belong to the cytokine receptor superfamily, but they are structurally and functionally more related to each other and thus make up a ..
  24. ncbi Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation
    Xiaohui Lu
    Whitehead Institute for Biomedical Research and the Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 102:18962-7. 2005
    ..Here, we show that coexpression of the JAK2V617F mutant kinase with a homodimeric Type I cytokine receptor, the erythropoietin receptor (EpoR), the thrombopoietin receptor, or the granulocyte colony-stimulating-..
  25. ncbi TGF-beta is a bidirectional modulator of cytokine receptor expression on murine bone marrow cells. Differential effects of TGF-beta 1 and TGF-beta 3
    S E Jacobsen
    Laboratory of Leukocyte Biology, National Cancer Institute, Bethesda, MD 20892
    J Immunol 151:4534-44. 1993
    ..Therefore, the ability of TGF-beta to modulate the CSF receptor density/cell and/or the actual number of progenitors expressing CSF receptors directly correlates with the multifunctional effects of TGF-beta in hematopoiesis...
  26. ncbi Human leukocyte antigen and cytokine receptor gene polymorphisms associated with heterogeneous immune responses to mumps viral vaccine
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Pediatrics 121:e1091-9. 2008
    ..We set out to assess whether HLA and cytokine gene polymorphisms are associated with variations in the immune response to mumps viral vaccine...
  27. ncbi Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain
    K Ozaki
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1674, USA
    Proc Natl Acad Sci U S A 97:11439-44. 2000
    We have identified a type I cytokine receptor, which we have termed novel interleukin receptor (NILR), that is most related to the IL-2 receptor beta chain (IL-2Rbeta) and physically adjacent to the IL-4 receptor alpha chain gene on ..
  28. ncbi Mutations in cytokine receptor-like factor 1 (CRLF1) account for both Crisponi and cold-induced sweating syndromes
    N Dagoneau
    Department of Genetics and INSERM U781, Universite Paris Descartes, Paris, France
    Am J Hum Genet 80:966-70. 2007
    ..factor receptor gene in Crisponi syndrome and the identification of homozygote or compound heterozygote cytokine receptor-like factor 1 (CRLF1) mutations in four children from three unrelated families...
  29. ncbi Th17 T cells: linking innate and adaptive immunity
    Brigitta Stockinger
    Division of Molecular Immunology, The MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Semin Immunol 19:353-61. 2007
    ..Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity 1995;3(6):811-21; Kennedy J, Rossi DL, Zurawski SM, Vega Jr F, Kastelein RA, Wagner JL, et al...
  30. ncbi In vivo expression of cytokine receptor mRNA in atopic dermatitis
    R A Taha
    Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    J Allergy Clin Immunol 102:245-50. 1998
    ..Chronic lesions are rich in eosinophils and monocyte/macrophages and contain a greater number of IL-5, granulocyte-macrophage colony-stimulating factor (GM-CSF), and IL-12 (p40) mRNA-positive cells...
  31. ncbi Effects of in vivo exposure to bis(tri-n-butyltin)oxide, hexachlorobenzene, and benzo(a)pyrene on cytokine (receptor) mRNA levels in cultured rat splenocytes and on IL-2 receptor protein levels
    R J Vandebriel
    Laboratory for Pathology and Immunobiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Toxicol Appl Pharmacol 148:126-36. 1998
    ....
  32. ncbi A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits
    D H Presky
    Department of Inflammation Autoimmune Diseases, Hoffmann La Roche, Inc, Nutley, NJ 07110, USA
    Proc Natl Acad Sci U S A 93:14002-7. 1996
    ..This newly identified huIL-12R subunit is a member of the cytokine receptor superfamily, with closest resemblance to the beta-type cytokine receptor gp130 and the receptors for ..
  33. ncbi Lipopolysaccharide-induced liver apoptosis is increased in interleukin-10 knockout mice
    Jian Zhong
    Division of Digestive Diseases and Nutrition, Department of Internal Medicine, University of Kentucky Medical Center, MN649 0298, Lexington, KY 40536, USA
    Biochim Biophys Acta 1762:468-77. 2006
    ..In addition, pro-inflammatory cytokine receptor mRNA levels (TNF-alpha, TGF-beta, and IL-1 beta) were markedly up-regulated by LPS at all time points in IL-..
  34. ncbi Differentiation induced by the c-Mpl cytokine receptor is blocked by mutant Shc adaptor protein
    R J Hill
    Department of Hematology, SUGEN, Inc, Redwood City, California 94063, USA
    Cell Growth Differ 7:1125-34. 1996
    c-Mpl, a member of the cytokine receptor superfamily, induces both proliferative and differentiation responses when stimulated with its ligand thrombopoietin (TPO)...
  35. ncbi SNP/haplotype associations in cytokine and cytokine receptor genes and immunity to rubella vaccine
    Neelam Dhiman
    Mayo Clinic Vaccine Research Group, Mayo Clinic, Guggenheim 611C, 200 First Street SW, Rochester, MN 55905, USA
    Immunogenetics 62:197-210. 2010
    ..Identification of such "genetic fingerprints" may predict the outcome of vaccine response and inform new vaccine strategies...
  36. ncbi Cytokines, acute-phase proteins, and hormones: IL-1 and TNF-alpha production in contact-mediated activation of monocytes by T lymphocytes
    Danielle Burger
    Division of Immunology and Allergy Hans Wilsdorf Laboratory, Department of Internal Medicine, University Hospital, CH 1211 Geneva 14, Switzerland
    Ann N Y Acad Sci 966:464-73. 2002
    ..taking into account the levels of other synergistic cytokines, of their respective inhibitors, and of each cytokine receptor. Due to their potent activities in many different processes (including cell growth and differentiation, ..
  37. ncbi Synergistic growth of stem cell factor and granulocyte macrophage colony-stimulating factor involves kinase-dependent and -independent contributions from c-Kit
    Johan Lennartsson
    Basic Research Laboratory, Center for Cancer Research, NCI, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 279:44544-53. 2004
    ..SCF also synergizes with a variety of growth factors, including those binding members of the cytokine receptor superfamily. The mechanisms mediating this synergy remain to be defined...
  38. ncbi Immune regulation at the interface during early steps of murine implantation: involvement of two new cytokines of the IL-12 family (IL-23 and IL-27) and of TWEAK
    Anne Elisabeth Mas
    Unité 782 INSERM, Hôpital Antoine Béclére AP HP 92141 Clamart, France
    Am J Reprod Immunol 59:323-38. 2008
    ..We therefore searched for regulators of the IL-12/IL-18 family of cytokines as well as for antagonist(s) of TNF with potentially selective effects on implantation...
  39. ncbi Expression analysis and characterization of alternatively spliced transcripts of human IL-7Ralpha chain encoding two truncated receptor proteins in relapsed childhood all
    A Korte
    Department of Pediatric Oncology Hematology, Charite Medical Center, Campus Virchow, Germany
    Cytokine 12:1597-608. 2000
    ..The splicing-derived cytokine receptor protein isoforms are mostly soluble receptors or show alterations in their cytoplasmic domain...
  40. ncbi Deficiency in EBV-induced gene 3 (EBI3) in MRL/lpr mice results in pathological alteration of autoimmune glomerulonephritis and sialadenitis
    Takashi Igawa
    Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    Mod Rheumatol 19:33-41. 2009
    ..the role of IL-27 in the development of autoimmune disorders in MRL/lpr mice, we disrupted the EBV-induced gene 3 (EBI3), which is a subunit of IL-27...
  41. ncbi CYRL, a novel cytokine receptor-like protein expressed in testis, lung, and spleen
    S L Chritton
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, 02114, USA
    Biochem Biophys Res Commun 267:697-702. 2000
    ..of a rat brain cDNA transcript with significant homology to IL-3Ralpha, which we have termed CYRL, for CYtokine Receptor-Like protein...
  42. ncbi A novel type I cytokine receptor is expressed on monocytes, signals proliferation, and activates STAT-3 and STAT-5
    Nico Ghilardi
    Department of Molecular Oncology, Genentech, Inc, South San Francisco, California 94080, USA
    J Biol Chem 277:16831-6. 2002
    Here we report the cloning of a novel type I cytokine receptor, gp130-like monocyte receptor (GLM-R), with homology to the interleukin-6 receptor signal transducing chain, gp130, and granulocyte colony-stimulating factor receptor...
  43. ncbi A cytokine receptor gene cluster in the X-Y pseudoautosomal region?
    E Kremer
    Department of Cytogenetics and Molecular Genetics, Women s and Children s Hospital, North Adelaide, Australia
    Blood 82:22-8. 1993
    ..Using long-range restriction mapping we have found that IL3RA maps to the same 190-kb restriction fragment as CSF2RA, suggesting that a cytokine receptor gene cluster may reside in the PAR.
  44. ncbi Comparative study on the expression of cytokine--receptor genes in normal and preeclamptic human placentas using DNA microarrays
    Zhan Jun Pang
    Department of Obstetrics and Gynecology, Nanfang Hospital, First Military Medical University, Guangzhou, China
    J Perinat Med 31:153-62. 2003
    ..To study the relationship between the expression levels of cytokine/receptor genes in placenta and the pathogenesis of pre-eclampsia...
  45. ncbi Cold-induced sweating syndrome with neonatal features of Crisponi syndrome: longitudinal observation of a patient homozygous for a CRLF1 mutation
    Masanori Yamazaki
    Department of Aging Medicine and Geriatrics, Shinshu University School of Medicine, Matsumoto, Japan
    Am J Med Genet A 152:764-9. 2010
    Cold-induced sweating syndrome (CISS) is a rare autosomal recessive disorder caused by mutations in CRLF1 (cytokine receptor-like factor 1), characterized by profuse sweating in cold environmental temperature and craniofacial and ..
  46. ncbi Molecular cloning of a human novel type I cytokine receptor related to delta1/TSLPR
    Y Tonozuka
    Division of Hematopoietic Factors, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Cytogenet Cell Genet 93:23-5. 2001
    In a search for a human sequence related to a recently identified type I cytokine receptor delta1, which turned out to be a receptor subunit for a cytokine called TSLP, we have now identified a novel human type I cytokine receptor from a ..
  47. ncbi Interleukin-2 induces NF-kappaB activation through BCL10 and affects its subcellular localization in natural killer lymphoma cells
    Ka Kui Chan
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    J Pathol 221:164-74. 2010
    ..We also found that BCL10, a key mediator of NF-kappaB signalling, participates in the cytokine receptor-induced activation of NF-kappaB...
  48. ncbi Analysis of interleukin receptor gene expression in mouse fetal liver by quantitative polymerase chain reaction
    G Q Jia
    Center for Blood Research, Inc, Harvard Medical School, Boston, MA 02115, USA
    Eur J Immunol 25:2096-100. 1995
    ..sensitive polymerase chain reaction (PCR)-based method for the quantification of low-abundance RNA for mouse cytokine receptor genes...
  49. ncbi A novel type-1 cytokine receptor from fish involved in the Janus kinase/signal transducers and activators of transcription (Jak/STAT) signal pathway
    Mudjekeewis D Santos
    Laboratory of Genome Science, Tokyo University of Marine Science and Technology, Konan 4 5 7 Minato ku, Tokyo 108 8477, Japan
    Mol Immunol 44:3355-63. 2007
    ..Here we report a novel cytokine receptor termed Japanese flounder glycoprotein 130 homologue or JfGPH, exhibiting the unique type I cytokine receptor ..
  50. ncbi Associations between measles vaccine immunity and single-nucleotide polymorphisms in cytokine and cytokine receptor genes
    Neelam Dhiman
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    J Infect Dis 195:21-9. 2007
    ..Cytokines are key regulators of measles vaccine humoral and cellular immunity. Single-nucleotide polymorphisms (SNPs) that are associated with differences in cytokine levels should also influence measles vaccine-induced immunity...
  51. ncbi NMR backbone dynamics of the human type I interferon binding subunit, a representative cytokine receptor
    Jordan H Chill
    Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Biochemistry 43:10127-37. 2004
    ..As the first cytokine receptor structure determined in the unliganded state and in solution, IFNAR2-EC offers an opportunity to ..
  52. ncbi RANKL in human periapical granuloma: possible involvement in periapical bone destruction
    R Vernal
    Periodontal Biology Laboratory, Dentistry Faculty, University of Chile, Santiago, Chile
    Oral Dis 12:283-9. 2006
    The cytokine receptor activator of nuclear factor kappaB-ligand (RANKL) has been involved in both the physiological and pathological regulation of osteoclast life span and bone metabolism...
  53. ncbi Growth hormone receptor interaction with Jak proteins differs between tissues
    G Hellgren
    Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    J Interferon Cytokine Res 21:75-83. 2001
    Janus kinases (Jak) play an important role in the initial steps of cytokine receptor signaling. The specificity of the four members of the Jak family (Jak1, Jak2, Jak3, and Tyk2) for different cytokine receptors is not fully understood...
  54. ncbi Impact of cytokine and cytokine receptor gene polymorphisms on cellular immunity after smallpox vaccination
    Inna G Ovsyannikova
    Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Gene 510:59-65. 2012
    We explored associations between SNPs in cytokine/cytokine receptor genes and cellular immunity in subjects following primary smallpox vaccination...
  55. ncbi The role of prolactin receptor in GH signaling in breast cancer cells
    Jie Xu
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Mol Endocrinol 27:266-79. 2013
    ..Their receptors (GHR and PRLR) reside in the cytokine receptor superfamily and share signaling pathways. In humans, GH binds both GHR and PRLR, whereas PRL binds only PRLR...
  56. ncbi Replication of associations between cytokine and cytokine receptor single nucleotide polymorphisms and measles-specific adaptive immunophenotypic extremes
    Sarah J White
    Mayo Clinic Vaccine Research Group, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Hum Immunol 73:636-40. 2012
    Our objective was to replicate previously reported associations between cytokine and cytokine receptor SNPs and humoral and CMI (cell-mediated immune) responses to measles vaccine...
  57. ncbi The effect of T1 and T2 cytokines on the cytotoxic T cell response to mannan-MUC1
    C J Lees
    Austin Research Institute, Studley Road, Heidelberg, Vic 3084 Australia
    Cancer Immunol Immunother 48:644-52. 2000
    ..Tumour challenges using MUC1(+) P815 cells, demonstrated that the addition of cytokines had little additive effect on the already effective tumour-regression capabilities of M-FP alone...
  58. ncbi The kinase inhibitor tofacitinib in patients with rheumatoid arthritis: latest findings and clinical potential
    Maurizio Cutolo
    Department of Internal Medicine, University of Genova Italy, Viale Benedetto XV, 6, 16132 Genova, Italy
    Ther Adv Musculoskelet Dis 5:3-11. 2013
    ..In particular, JAK3 is the only JAK family member that associates with just one cytokine receptor, the common gamma chain, which is exclusively used by the receptors for IL-2, IL-4, IL-7, IL-9, IL-15 and IL-..
  59. ncbi An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer
    Christoph Garbers
    Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich Heine University, 40225 Dusseldorf, Germany
    J Biol Chem 288:4346-54. 2013
    IL-27 consists of the cytokine subunit p28 and the non-signaling α-receptor EBI3. p28 was shown to additionally act via the non-signaling membrane-bound IL-6 α-receptor (IL-6R) as an agonistic cytokine but also as a gp130 β-receptor ..
  60. ncbi IL-27 production and STAT3-dependent upregulation of B7-H1 mediate immune regulatory functions of liver plasmacytoid dendritic cells
    Benjamin M Matta
    Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Immunol 188:5227-37. 2012
    ..In this study, we show that mouse liver pDCs express higher levels of IL-27p28 and EBV-induced protein 3 (Ebi3) compared with those of splenic pDCs...
  61. ncbi Chemotactic cytokine receptor 5 gene polymorphism: relevance to microvascular complications in type 2 diabetes
    Monika Buraczynska
    Laboratory for DNA Analysis and Molecular Diagnostics, Department of Nephrology, Medical University of Lublin, Lublin, Poland
    Cytokine 58:213-7. 2012
    We investigated the involvement of chemotactic cytokine receptor 5 (CCR5) gene polymorphism in microvascular complications of T2DM. All subjects were genotyped with the 59029 SNP in the CCR5 gene...
  62. ncbi Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition
    Oliver Weigert
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Exp Med 209:259-73. 2012
    ..myeloproliferative neoplasms (MPNs), B cell acute lymphoblastic leukemia (B-ALL) with rearrangements of the cytokine receptor subunit cytokine receptor-like factor 2 (CRLF2), and other tumors with constitutive JAK2 signaling...
  63. ncbi Effects on apoptosis and cell cycle arrest contribute to the antitumor responses of interleukin-27 mediated by retrovirus in human pancreatic carcinoma cells
    Lihua Liu
    Research Center, Department of Clinical Cell Therapy, the Fourth Hospital of Hebei Medical University and Hebei Cancer Institute, Shijiazhuang 050011, PR China
    Oncol Rep 27:1497-503. 2012
    Interleukin (IL)-27, composed of p28 and Epstein-Barr virus-induced gene 3 (EBI3) subunits, has diverse functions in regulating immune systems...
  64. ncbi The RANKL distal control region is required for the increase in RANKL expression, but not the bone loss, associated with hyperparathyroidism or lactation in adult mice
    Melda Onal
    Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Mol Endocrinol 26:341-8. 2012
    Osteoclast-mediated bone resorption plays an essential role in calcium homeostasis and lactation. The cytokine receptor activator of nuclear factor κB ligand (RANKL) is one of a number of factors that controls the production, survival, ..
  65. ncbi Urinary evaluation of the balance between soluble interferon-gamma receptor (IFN-gammaR1) and interleukin-4 receptor (IL-4Ralpha)
    Yoshihiro Okamoto
    Laboratory of Immunology and Microbiology, Faculty of Pharmacy, Chiba Institute of Science, 3 Shiomi cho, Choshi, Chiba 288 0025, Japan
    Int Immunopharmacol 8:1859-62. 2008
    ..we determined the levels of both the soluble interferon-gamma receptor alpha chain (sIFN-gammaR1, Th1-type cytokine receptor) and the soluble interleukin 4-receptor alpha chain (sIL-4Ralpha, Th2-type cytokine receptor) in the urine ..
  66. ncbi Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130
    A O Chua
    Department of Inflammation Autoimmune Diseases, Roche Research Center, Hoffmann La Roche Inc, Nutley, NJ 07110
    J Immunol 153:128-36. 1994
    ....
  67. ncbi Raised expression of cytokine receptor gp130 subunit on peripheral lymphocytes of patients with active lupus. A useful tool for monitoring the disease activity?
    M de la Torre
    Nephrology Service, Hospital San Agustin, Aviles, Spain
    Lupus 18:216-22. 2009
    ..75. In conclusion, there is an altered expression of gp130 in the patients with SLE. The disease activity as well as immunotherapy seems to influence the pattern of expression of gp130 on B-cell subsets in patients with SLE...
  68. ncbi Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group
    Libi Hertzberg
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Blood 115:1006-17. 2010
    ..Nevertheless, 62% (33/53) of the DS-ALL samples analyzed were characterized by high expression of the type I cytokine receptor CRLF2 caused by either immunoglobulin heavy locus (IgH@) translocations or by interstitial deletions ..
  69. ncbi The IL-27 p28 subunit binds cytokine-like factor 1 to form a cytokine regulating NK and T cell activities requiring IL-6R for signaling
    Sandrine Crabé
    Departement de Pharmacologie, Universite de Montreal, Montreal, Canada
    J Immunol 183:7692-702. 2009
    IL-27 is formed by the association of a cytokine subunit, p28, with the soluble cytokine receptor EBV-induced gene 3 (EBI3). The IL-27R comprises gp130 and WSX-1...
  70. ncbi Point mutation of tyrosine 759 of the IL-6 family cytokine receptor, gp130, augments collagen-induced arthritis in DBA/1J mice
    Fumio Tsuji
    Research and Development Center, Santen Pharmaceutical Co, Ltd, Ikoma shi, Nara, Japan
    BMC Musculoskelet Disord 10:23. 2009
    ..We conducted a detailed analysis of collagen-induced arthritis (CIA) in gp130F759 with a DBA/1J background (D/J.gp130F759)...
  71. ncbi Cytokine receptor-like factor 1 is highly expressed in damaged human knee osteoarthritic cartilage and involved in osteoarthritis downstream of TGF-beta
    Katsuki Tsuritani
    Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School of Natural Science and Technology, Kakuma machi, Kanazawa, Japan
    Calcif Tissue Int 86:47-57. 2010
    ..A component of the complex, CRLF1, may be useful as a biomarker of OA; and the corresponding receptor is a potential new drug target for OA...
  72. ncbi Variation in cytokine genes can contribute to severity of acetabular osteolysis and risk for revision in patients with ABG 1 total hip arthroplasty: a genetic association study
    Jiri Gallo
    Department of Orthopaedics, Teaching Hospital and Faculty of Medicine and Dentistry, Palacky University, I P Pavlova 6, Olomouc775 20, Czech Republic Laboratory of Immunogenomics, Faculty of Medicine and Dentistry, Palacky University, I P Pavlova 6, Olomouc 775 20, Czech Republic
    BMC Med Genet 10:109. 2009
    ..This may be driven by functional polymorphisms in the genes for cytokines and cytokine receptors involved in the development of osteolysis in THA, thereby having an effect on the individual's phenotype...
  73. ncbi Human CD4+ CD25+ Foxp3+ regulatory T cells do not constitutively express IL-35
    Emilie Bardel
    Centre National de la Recherche Scientifique Unité Mixte de Recherche 8147, Universite Paris Descartes, Paris, France
    J Immunol 181:6898-905. 2008
    EBV-induced gene 3 (EBI3) can associate with p28 to form the heterodimeric cytokine IL-27, or with the p35 subunit of IL-12 to form the EBI3/p35 heterodimer, recently named IL-35...
  74. ncbi Cytokine and cytokine receptor single-nucleotide polymorphisms predict risk for non-small cell lung cancer among women
    Alison L Van Dyke
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Cancer Epidemiol Biomarkers Prev 18:1829-40. 2009
    ..study on 198 African-American and 744 Caucasian women, we examined the association between 70 cytokine and cytokine receptor single-nucleotide polymorphisms (SNPs) and risk of non-small cell lung cancer (NSCLC)...
  75. ncbi Cloning and expression of a gene encoding an interleukin 3 receptor-like protein: identification of another member of the cytokine receptor gene family
    D M Gorman
    DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304
    Proc Natl Acad Sci U S A 87:5459-63. 1990
    ..A consensus sequence defining an additional cytokine receptor family is present in this clone...
  76. ncbi DNA damage stress and inhibition of Jak2-V617F cause its degradation and synergistically induce apoptosis through activation of GSK3β
    Toshikage Nagao
    Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    PLoS ONE 6:e27397. 2011
    The cytoplasmic tyrosine kinase Jak2 plays a crucial role in cytokine receptor signaling in hematopoietic cells...
  77. ncbi The SOCS2 ubiquitin ligase complex regulates growth hormone receptor levels
    Mattias Vesterlund
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 6:e25358. 2011
    ..GH actions are mediated by the Growth Hormone Receptor; a member of the cytokine receptor super family that signals chiefly through the JAK2/STAT5 pathway...
  78. ncbi IL-27 inhibits hyperglycemia and pancreatic islet inflammation induced by streptozotocin in mice
    Hirokazu Fujimoto
    Department of Cardiovascular Medicine, Saga University Faculty of Medicine, Saga, Japan
    Am J Pathol 179:2327-36. 2011
    ..IL-27, a cytokine consisting of IL-27p28 and Epstein-Barr virus-induced gene 3 (EBI3), binds a membrane-bound heterodimeric receptor consisting of the IL-27 receptor α chain (WSX-1) and gp130...
  79. ncbi Rationalizing 5000-fold differences in receptor-binding rate constants of four cytokines
    Xiaodong Pang
    Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida, USA
    Biophys J 101:1175-83. 2011
    ..Together these results suggest that protein charges can be manipulated to tune k(a) and control biological function...
  80. ncbi Cell therapy with autologous tolerogenic dendritic cells induces allograft tolerance through interferon-gamma and epstein-barr virus-induced gene 3
    M Hill
    INSERM, UMR 643, Nantes, France
    Am J Transplant 11:2036-45. 2011
    ..ATDCs expressed the cytokinic chain Epstein-Barr virus-induced gene 3 (EBI3), an IL-12 family member...
  81. ncbi Impact of immunogenetic polymorphisms in bone marrow failure syndromes
    B Serio
    Hematology Branch, School of Medicine, University of Salerno, Italy
    Mini Rev Med Chem 11:544-52. 2011
    ....
  82. ncbi RNF41 (Nrdp1) controls type 1 cytokine receptor degradation and ectodomain shedding
    Joris Wauman
    Department of Medical Protein Research, Flanders Interuniversity Institute for Biotechnology VIB, Ghent University, Albert Baertsoenkaai 3, B 9000 Ghent, Belgium
    J Cell Sci 124:921-32. 2011
    ..finger protein 41 (RNF41, also known as E3 ubiquitin-protein ligase Nrdp1) interacts with JAK2-associated cytokine receptor complexes and modulates their cell surface exposure and signalling...
  83. ncbi Growth hormone signaling in human T47D breast cancer cells: potential role for a growth hormone receptor-prolactin receptor complex
    Jie Xu
    Department of Medicine, University of Alabama at Birmingham, Alabama 35294 0012, USA
    Mol Endocrinol 25:597-610. 2011
    GH receptor (GHR) and prolactin (PRL) receptor (PRLR) are structurally similar cytokine receptor superfamily members that are highly conserved among species...
  84. ncbi EBI3 deficiency leads to diminished T helper type 1 and increased T helper type 2 mediated airway inflammation
    Elif Dokmeci
    Department of Pediatrics, Section of Pediatric Pulmonology, Yale University School of Medicine, New Haven, CT, USA
    Immunology 132:559-66. 2011
    ..A critical role for Epstein-Barr virus-induced gene 3 (EBI3) in these responses has been proposed...
  85. ncbi Associations between single nucleotide polymorphisms and haplotypes in cytokine and cytokine receptor genes and immunity to measles vaccination
    Iana H Haralambieva
    Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Vaccine 29:7883-95. 2011
    ..We performed a comprehensive candidate gene association study across 801 genetic markers in 56 cytokine/cytokine receptor genes, in a racially diverse cohort of 745 schoolchildren after two doses of MMR vaccine...
  86. ncbi Molecular identification of duck and quail common cytokine receptor γ chain genes
    Jipseol Jeong
    College of Veterinary Medicine and Research Institute of Life Science, Gyeongsang National University, 900 Gajwa dong, Jinju, Gyeongnam 660 701, Republic of Korea
    Vet Immunol Immunopathol 140:159-65. 2011
    Common cytokine receptor γ chain (γ(c)) family cytokines play crucial roles in the regulation of innate and adaptive immune responses. Unlike mammals, chickens possess two different γ(c) transcripts...
  87. ncbi In vivo analysis of Ifn-γ1 and Ifn-γ2 signaling in zebrafish
    Dina Aggad
    Dynamique des Interactions Membranaires Normales et Pathologiques, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5235, Montpellier, France
    J Immunol 185:6774-82. 2010
    The zebrafish genome contains a large number of genes encoding potential cytokine receptor genes as judged by homology to mammalian receptors...
  88. ncbi Molecular basis of cytokine receptor activation
    Angel F Lopez
    The Centre for Cancer Biology, SA Pathology, Adelaide, SA, Australia
    IUBMB Life 62:509-18. 2010
    ..diseases and a number of haematological malignancies are driven by deregulated GM-CSF, IL-3, or IL-5 cytokine receptor signaling, highlighting their importance in disease...
  89. ncbi Bone density and hyperlipidemia: the T-lymphocyte connection
    Lucia S Graham
    Department of Pathology and Laboratory Medicine and David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095 1732, USA
    J Bone Miner Res 25:2460-9. 2010
    ..Together these findings suggest that T-lymphocytes play a key role in the osteoclastogenesis induced by a high-fat diet and may contribute to the bone loss associated with diet-induced osteopenia...
  90. ncbi Crystal structure of the entire ectodomain of gp130: insights into the molecular assembly of the tall cytokine receptor complexes
    Yibin Xu
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia
    J Biol Chem 285:21214-8. 2010
    ..This represents the first atomic resolution structure of the complete ectodomain of any "tall" cytokine receptor. These structures show that other than a reorientation of the D1 domain, there is little structural change ..
  91. ncbi Unusual water-mediated antigenic recognition of the proinflammatory cytokine interleukin-18
    Maria A Argiriadi
    Department of Biochemistry, Abbott Laboratories, Worcester, Massachusetts 01605, USA
    J Biol Chem 284:24478-89. 2009
    ..Thus, counterintuitively, tight and specific antibody binding may in some cases be water-mediated...
  92. ncbi PRL receptor-mediated effects in female mouse adipocytes: PRL induces suppressors of cytokine signaling expression and suppresses insulin-induced leptin production in adipocytes in vitro
    C Ling
    Department of Physiology, Goteborg University, SE 405 30 Goteborg, Sweden
    Endocrinology 142:4880-90. 2001
    ..The PRLR belongs to the cytokine receptor family, and a family of suppressors of cytokine signaling (SOCS) was recently identified...
  93. ncbi Regulation of cytokine receptor signaling by nuclear hormone receptors: a new paradigm for receptor interaction
    Kin Chuen Leung
    Pituitary Research Unit, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
    DNA Cell Biol 23:463-74. 2004
    ..NHRs regulate cytokine receptor signaling by affecting STAT expression and by acting as coregulators of STAT transcriptional action...
  94. ncbi Reversal of antigen-dependent signaling by two mutations in antibody/receptor chimera: implication of inverse agonism in cytokine receptor superfamily
    Masahiro Kawahara
    Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 8656, Japan
    Biochem Pharmacol 68:539-48. 2004
    ..how agonism and antagonism could be altered by randomizing antibody variable region of an antibody/cytokine receptor chimera recognizing hen egg lysozyme (HEL) as an agonist...
  95. ncbi Expression of IL-27 in human Th1-associated granulomatous diseases
    Frederique Larousserie
    CNRS FRE 2444, Universite Paris V, IFR Necker, Paris, France
    J Pathol 202:164-71. 2004
    ..It is a heterodimeric cytokine composed of two subunits, p28 and Epstein-Barr virus-induced gene 3 (EBI3). In vitro studies have shown that IL-27 is mainly produced by activated monocytes and dendritic cells...
  96. ncbi Circadian rhythms of basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3), cortisol, and melatonin in women with breast cancer
    E Haus
    HealthPartners Regions Hospital University of Minnesota, St Paul, USA
    Chronobiol Int 18:709-27. 2001
    ..Circadian rhythms in plasma concentrations of many hormones and cytokines determine their effects on target cells...
  97. ncbi G-CSF-induced tyrosine phosphorylation of Gab2 is Lyn kinase dependent and associated with enhanced Akt and differentiative, not proliferative, responses
    Quan Sheng Zhu
    Division of Pediatrics, University of Texas M D Anderson Cancer, Houston, TX 77030, USA
    Blood 103:3305-12. 2004
    ..Studies suggest that Gab2 plays both positive and negative roles in cytokine receptor signaling...
  98. ncbi Differential chemokine, chemokine receptor, cytokine and cytokine receptor expression in pulmonary adenocarcinoma: diffuse down-regulation is associated with immune evasion and brain metastasis
    Koichi Ohshima
    Department of Pathology, School of Medicine, Fukuoka University, Fukuoka 814 0180, Japan
    Int J Oncol 23:965-73. 2003
    ..The relationships between the cytokines and cytokine receptor (R), and between chemokines and chemokine R are important determinants of selectivity in local immunity...
  99. ncbi Threonine 391 phosphorylation of the human prolactin receptor mediates a novel interaction with 14-3-3 proteins
    Monilola A Olayioye
    Walter and Eliza Hall Institute of Medical Research and Bone Marrow Research Laboratories, 1G Royal Parade, Victoria 3050, Australia
    J Biol Chem 278:32929-35. 2003
    The prolactin receptor (PrlR) is a member of the cytokine receptor superfamily that lacks an intrinsic kinase domain and relies on the cytoplasmic Jak tyrosine kinases to transduce signals...
  100. ncbi Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2
    Catherine Abbadie
    Department of Pharmacology, Merck Research Laboratories, P O Box 2000, Rahway, NJ 07065, USA
    Proc Natl Acad Sci U S A 100:7947-52. 2003
    Mice lacking the chemokine receptor chemotactic cytokine receptor 2 (CCR2) have a marked attenuation of monocyte recruitment in response to various inflammatory stimuli and a reduction of inflammatory lesions in models of demyelinating ..
  101. ncbi Characterization and transcriptional analysis of the mouse Chromosome 16 cytokine receptor gene cluster
    Matthew P Hardy
    Centre for Functional Genomics and Human Disease, Monash Institute of Reproduction and Development, Monash University, Clayton, Victoria 3168, Australia
    Mamm Genome 14:105-18. 2003
    The class II cytokine receptor (CIICR) genes Il10r2 and Ifnar1 are localized on mouse Chr 16 in a cluster that also contains the CIICR genes Ifnar2 and Ifngr2...

Research Grants89

  1. Il-7 receptor signaling in lymphopoiesis
    Motonari Kondo; Fiscal Year: 2009
    ..t. IL-7 receptor is composed of two different cytokine receptor subunits; the IL-?7 receptor alpha chaininandthecommongammachainin....
  2. GI Nematodes and Gut Functional Responses to Inflammation
    Terez Shea Donohue; Fiscal Year: 2011
    ..pathways;3) activation of STAT6 signaling resulted in up-regulation of genes that affect function;and 4) cytokine receptor expression was different in the small intestine and colon and is altered by infection...
  3. GI Nematodes and Gut Functional Responses to Inflammation
    Terez Shea Donohue; Fiscal Year: 2009
    ..pathways; 3) activation of STAT6 signaling resulted in up-regulation of genes that affect function; and 4) cytokine receptor expression was different in the small intestine and colon and is altered by infection...
  4. GI Nematodes and Gut Functional Responses to Inflammation
    Terez Shea Donohue; Fiscal Year: 2010
    ..pathways;3) activation of STAT6 signaling resulted in up-regulation of genes that affect function;and 4) cytokine receptor expression was different in the small intestine and colon and is altered by infection...
  5. Phase II, IL-1 Trap for Treatment of Familial Mediterranean Fever
    Steven J Spalding; Fiscal Year: 2010
    ..They propose to use IL-1 Trap, a fusion protein consisting of human IL-1 cytokine receptor extracellular domains and the FC portion of human immunoglobulin G (lgG) that binds and neutralizes IL-1...
  6. Phase II, IL-1 Trap for Treatment of Familial Mediterranean Fever
    PHILLIP HASHKES; Fiscal Year: 2007
    ..They propose to use IL-1 Trap, a fusion protein consisting of human IL-1 cytokine receptor extracellular domains and the FC portion of human immunoglobulin G (lgG) that binds and neutralizes IL-1...
  7. Identification of Biofilm-Induced Staphylococcus aureus Cytokine Receptors
    ARLENE HOOGEWERF; Fiscal Year: 2006
    ..by flow cytometry; co-precipitation, proteomics, and transposon mutagenesis will be used to identify cytokine receptor genes. Transposon mutagenesis or allelic replacement will be used to prepare cytokine receptor mutants...
  8. Anti-Apoptotic Signaling by the IL-2/15 Receptor
    SARAH GAFFEN; Fiscal Year: 2006
    ..Moreover, genetic deficiencies in certain cytokine receptor components cause several immunodeficiency and/or autoimmune syndromes...
  9. INTERLEUKIN 4 REGULATION OF LYMPHOCYTES
    Mark R Boothby; Fiscal Year: 2010
    ..whether or not a common set of signal transduction pathways recruited after T cell activation endows this cytokine receptor with each of its altered functional characteristics...
  10. INTERLEUKIN 4 REGULATION OF LYMPHOCYTES
    Mark Boothby; Fiscal Year: 2004
    ..To bypass these obstacles, we created a transgenic mouse model in which expression of a chimeric cytokine receptor was targeted to the T lymphoid lineage...
  11. INTERLEUKIN 4 REGULATION OF LYMPHOCYTES
    Mark Boothby; Fiscal Year: 2007
    ..whether or not a common set of signal transduction pathways recruited after T cell activation endows this cytokine receptor with each of its altered functional characteristics...
  12. INTERLEUKIN 4 REGULATION OF LYMPHOCYTES
    Mark Boothby; Fiscal Year: 2009
    ..whether or not a common set of signal transduction pathways recruited after T cell activation endows this cytokine receptor with each of its altered functional characteristics...
  13. Novel Myeloid Cell Transforming Properties of Interleukin-27 Receptor
    Gary W Reuther; Fiscal Year: 2010
    ..studies are to characterize the transforming properties of the receptor for interleukin-27 (IL27R), a type I cytokine receptor, and to determine the contribution of IL27R to the development of leukemia...
  14. SIGNAL TRANSDUCTION MECHANISMS OF ERYTHROPOIETIN
    Barbara A Miller; Fiscal Year: 2010
    The erythropoietin (Epo) receptor is a model for understanding signal transduction mechanisms of the cytokine receptor superfamily...
  15. SIGNAL TRANSDUCTION MECHANISMS OF ERYTHROPOIETIN
    Barbara A Miller; Fiscal Year: 2010
    The erythropoietin (Epo) receptor is a model for understanding signal transduction mechanisms of the cytokine receptor superfamily...
  16. Erythropoietin receptors in breast cancer
    MURAT ARCASOY; Fiscal Year: 2007
    ..production of red blood cells by binding to its specific cell surface receptor EpoR, a member of the Type I cytokine receptor family...
  17. SIGNAL TRANSDUCTION MECHANISMS OF ERYTHROPOIETIN
    Barbara Miller; Fiscal Year: 2009
    The erythropoietin (Epo) receptor is a model for understanding signal transduction mechanisms of the cytokine receptor superfamily...
  18. Effect of HIV Infection and HAART on Bone Homeostasis
    MERVYN NEALE contact WEITZMANN; Fiscal Year: 2010
    ..Osteoclasts the cells responsible for bone resorption form under the influence of the key osteoclastogenic cytokine Receptor- Activator of NF-:B (RANKL)...
  19. Amelioration of Immune Cell-Mediated Periodontal Disease
    Martin Taubman; Fiscal Year: 2009
    ....
  20. Amelioration of Immune Cell-Mediated Periodontal Disease
    Martin A Taubman; Fiscal Year: 2010
    ....
  21. SRC-LIKE KINASES IN INTERLEUKIN-3 RECEPTOR SIGNALING
    Steven Anderson; Fiscal Year: 2001
    ..mitogenesis, but it is not understood how their activation is regulated or what role they play in cytokine receptor signaling...
  22. ANTIGEN-INDUCED B LYMPHOCYTE DEVELOPMENT
    Douglas Fearon; Fiscal Year: 2006
    ..of SHP-1 in the germinal center B cell is required, and whether this permits signaling through a gamma-c cytokine receptor; 3) whether arrested terminal differentiation by BCL-6 is the basis for B cell memory; 4) whether signaling ..
  23. Growth Hormone Receptor Dimerization/Disulfide Linkage
    STUART FRANK; Fiscal Year: 2005
    ..GH receptor (GHR) is a member of the cytokine receptor superfamily...
  24. IMMUNOGENETIC MECHANISMS OF VACCINE RESPONSE
    Gregory A Poland; Fiscal Year: 2010
    ..protein messengers, and their receptors, in the immune response cascade, the role of cytokine and cytokine receptor gene polymorphisms will be a primary focus of this application, and we will focus on the influence of these ..
  25. IMMUNOGENETIC MECHANISMS OF VACCINE RESPONSE
    Gregory Poland; Fiscal Year: 2007
    ..protein messengers, and their receptors, in the immune response cascade, the role of cytokine and cytokine receptor gene polymorphisms will be a primary focus of this application, and we will focus on the influence of these ..
  26. Il-7 receptor signaling in lymphopoiesis
    Motonari Kondo; Fiscal Year: 2007
    ..IL-7 receptor is composed of two different cytokine receptor subunits, IL-7 receptor alpha chain and the common gamma chain...
  27. MECHANISMS OF PULMONARY FIBROSIS CAUSED BY SILICA
    Gerald Davis; Fiscal Year: 2003
    ..macrophages and target lung fibroblast cell lines isolated from wild-type mice and mutant strains with cytokine receptor deletions...
  28. The Immunogenetics of Measles Immunity
    Gregory Poland; Fiscal Year: 2009
    ..2, 3, IL-12, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12A, IL-12B, TNF1 and GM-CSF) and selected corresponding cytokine receptor genes (IL-1R1, IL-1R2, IL-1RN, IL-2RA, IL-2RB, IL- 2RG, IL-4RA, IL-5RA, IL-6R, IL-6ST, IL-10RA, IL-10RB, IL-..
  29. The Immunogenetics of Measles Immunity
    Gregory A Poland; Fiscal Year: 2010
    ..2, 3, IL-12, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12A, IL-12B, TNF1 and GM-CSF) and selected corresponding cytokine receptor genes (IL-1R1, IL-1R2, IL-1RN, IL-2RA, IL-2RB, IL- 2RG, IL-4RA, IL-5RA, IL-6R, IL-6ST, IL-10RA, IL-10RB, IL-..
  30. PTEN TUMOR SUPPRESSOR AND SIGNAL TRANSDUCTION
    Ramon Parsons; Fiscal Year: 2005
    ..member of a family of IRS genes that function as adaptor proteins for the transmission of insulin, IGF, and cytokine receptor signals. The major role of IRS-2 is to link an activated receptor to PI-3 kinase...
  31. MOLECULAR PATHWAYS IN MYELOPROLIFERATIVE DISEASE
    George Daley; Fiscal Year: 2002
    ..mutations arise in post-receptor signaling proteins, deregulating mitogenic pathways normally controlled by cytokine receptor signal transduction...
  32. Improving T-cell therapies for neuroblastoma
    Gianpietro Dotti; Fiscal Year: 2010
    ..therapy targeting neuroblastoma (NB) by co-expressing a tumor-specific chimeric antigen receptor (CAR) and a cytokine receptor. NB is the most common malignant extracranial tumor of childhood, and children with high-risk disease ..