Gene Symbol: E4F1
Description: E4F transcription factor 1
Alias: E4F, transcription factor E4F1, RING-type E3 ubiquitin transferase E4F1, p120E4F, p50E4F, transcription factor E4F
Species: human
Products:     E4F1

Top Publications

  1. Hatchi E, Rodier G, Lacroix M, Caramel J, Kirsh O, Jacquet C, et al. E4F1 deficiency results in oxidative stress-mediated cell death of leukemic cells. J Exp Med. 2011;208:1403-17 pubmed publisher
    The multifunctional E4F1 protein was originally discovered as a target of the E1A viral oncoprotein. Growing evidence indicates that E4F1 is involved in key signaling pathways commonly deregulated during cell transformation...
  2. Colombo R, Draetta G, Chiocca S. Modulation of p120E4F transcriptional activity by the Gam1 adenoviral early protein. Oncogene. 2003;22:2541-7 pubmed
    ..In this report, we identify the cellular transcription factor p120(E4F) as a Gam1 interaction partner...
  3. Le Cam L, Linares L, Paul C, Julien E, Lacroix M, Hatchi E, et al. E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation. Cell. 2006;127:775-88 pubmed
    ..Here, we identify the p53-associated factor E4F1, a ubiquitously expressed zinc-finger protein first identified as a cellular target of the viral oncoprotein E1A, ..
  4. Fajas L, Paul C, Zugasti O, Le Cam L, Polanowska J, Fabbrizio E, et al. pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F. Proc Natl Acad Sci U S A. 2000;97:7738-43 pubmed
    ..We report that pRB, but not p107 and p130, binds to and facilitates repression by p120(E4F), a ubiquitously expressed GLI-Kruppel-related protein identified as a cellular target of E1A...
  5. Rizos H, Diefenbach E, Badhwar P, Woodruff S, Becker T, Rooney R, et al. Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition. J Biol Chem. 2003;278:4981-9 pubmed
    ..We now report that p14(ARF) forms a complex with the E1A-regulated transcriptional repressor, p120(E4F)...
  6. Fenton S, Dallol A, Agathanggelou A, Hesson L, Ahmed Choudhury J, Baksh S, et al. Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene. Cancer Res. 2004;64:102-7 pubmed
    ..We identified the E1A-regulated transcription factor p120(E4F) as a RASSF1A interacting partner in yeast and mammalian cells, and demonstrated that RASSF1A protein and p120(E4F) ..
  7. Rui E, Moura P, Gonçalves K, Rooney R, Kobarg J. Interaction of the hepatitis B virus protein HBx with the human transcription regulatory protein p120E4F in vitro. Virus Res. 2006;115:31-42 pubmed
    ..as RXR and UVDDB1, we identified several new candidates including the human transcriptional regulatory protein p120E4F, which has been implicated in the regulation of mitosis and the cell cycle...
  8. Sandy P, Gostissa M, Fogal V, Cecco L, Szalay K, Rooney R, et al. p53 is involved in the p120E4F-mediated growth arrest. Oncogene. 2000;19:188-99 pubmed
    ..Here we demonstrate that p53 binds to the E1A-regulated transcription factor p120E4F, a transcriptional repressor of the adenovirus E4 promoter...
  9. Tessari M, Gostissa M, Altamura S, Sgarra R, Rustighi A, Salvagno C, et al. Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2. Mol Cell Biol. 2003;23:9104-16 pubmed
    ..Here we show that HMGA2 associates with the E1A-regulated transcriptional repressor p120(E4F), interfering with p120(E4F) binding to the cyclin A promoter...

More Information


  1. Paul C, Lacroix M, Iankova I, Julien E, Schafer B, Labalette C, et al. The LIM-only protein FHL2 is a negative regulator of E4F1. Oncogene. 2006;25:5475-84 pubmed
    The E1A-targeted transcription factor E4F1 is a key player in the control of mammalian embryonic and somatic cell proliferation and survival...
  2. Gui Z, Zhang H, Tan Q, Ling X, Liu Z, Peng J, et al. Poly(ADP-ribose) polymerase-1 promotes expression of miR-155 by the up-regulation of methyl-CpG binding domain protein 2 in TK6 cells exposed to hydroquinone. Toxicol In Vitro. 2018;55:51-57 pubmed publisher
    ..Meanwhile, E4F1, PARP-1 and PARP-1 related co-regulators (NF-κB, HDAC1, and HDAC2), acetylated histone H3 (H3Ac) were increased in ..
  3. Wang J, Ye L, Jin M, Wang X. Global analyses of Chromosome 17 and 18 genes of lung telocytes compared with mesenchymal stem cells, fibroblasts, alveolar type II cells, airway epithelial cells, and lymphocytes. Biol Direct. 2015;10:9 pubmed publisher
    ..to indicate the biological function of TCs in immune regulation, and up-regulated MCFD2 and down-regulated E4F1 and PDCD2 had an association with tissue homeostasis for TCs...
  4. Rodier G, Kirsh O, Baraibar M, Houlès T, Lacroix M, Delpech H, et al. The transcription factor E4F1 coordinates CHK1-dependent checkpoint and mitochondrial functions. Cell Rep. 2015;11:220-33 pubmed publisher
    ..Here, we show that another factor, the multifunctional protein E4F1, directly controls genes involved in mitochondria functions and cell-cycle checkpoints, including Chek1, a major ..
  5. Grote D, Moison C, Duhamel S, Chagraoui J, Girard S, Yang J, et al. E4F1 is a master regulator of CHK1-mediated functions. Cell Rep. 2015;11:210-9 pubmed publisher
    It has been previously shown that the polycomb protein BMI1 and E4F1 interact physically and genetically in the hematopoietic system. Here, we report that E4f1 is essential for hematopoietic cell function and survival...
  6. Lacroix M, Rodier G, Kirsh O, Houles T, Delpech H, Seyran B, et al. E4F1 controls a transcriptional program essential for pyruvate dehydrogenase activity. Proc Natl Acad Sci U S A. 2016;113:10998-1003 pubmed publisher
    ..another level of regulation of the pyruvate oxidation pathway in mammals implicating the E4 transcription factor 1 (E4F1)...
  7. Li Y, Peng L, Seto E. Histone Deacetylase 10 Regulates the Cell Cycle G2/M Phase Transition via a Novel Let-7-HMGA2-Cyclin A2 Pathway. Mol Cell Biol. 2015;35:3547-65 pubmed publisher
    ..HMGA2 loss resulted in enrichment of the transcriptional repressor E4F at the cyclin A2 promoter...
  8. Goguet Rubio P, Seyran B, Gayte L, Bernex F, Sutter A, Delpech H, et al. E4F1-mediated control of pyruvate dehydrogenase activity is essential for skin homeostasis. Proc Natl Acad Sci U S A. 2016;113:11004-9 pubmed publisher
    The multifunctional protein E4 transcription factor 1 (E4F1) is an essential regulator of epidermal stem cell (ESC) maintenance...
  9. Rizos H, Woodruff S, Kefford R. p14ARF interacts with the SUMO-conjugating enzyme Ubc9 and promotes the sumoylation of its binding partners. Cell Cycle. 2005;4:597-603 pubmed
    ..conjugating enzyme, Ubc9 and enhances the sumoylation of its binding partners, hdm2, E2F-1, HIF-1alpha, TBP-1 and p120E4F. Furthermore, p14ARF-induced sumoylation is abrogated by a subset of melanoma-associated p14ARF mutations...
  10. Dai Y, Cros M, Pontoizeau C, Elena Hermann B, Bonn G, Hainaut P. Downregulation of transcription factor E4F1 in hepatocarcinoma cells: HBV-dependent effects on autophagy, proliferation and metabolism. Carcinogenesis. 2014;35:635-50 pubmed publisher
    The multifunctional E4F1 protein is a cellular target of the E1A adenoviral oncoprotein. Interaction between E4F1 and the hepatitis B virus (HBV) protein HBx has been demonstrated in vitro...
  11. Rooney R, Raychaudhuri P, Nevins J. E4F and ATF, two transcription factors that recognize the same site, can be distinguished both physically and functionally: a role for E4F in E1A trans activation. Mol Cell Biol. 1990;10:5138-49 pubmed
    ..In contrast, another factor that recognizes this element, termed E4F, was found at only very low levels in uninfected cells but was increased markedly upon adenovirus infection, as ..
  12. Saccone S, Sandy P, Meroni G, Gostissa M, Della Valle G, Del Sal G. Assignment of the E1A-regulated transcription factor E4F gene (E4F1) to human chromosome band 16p13.3 by in situ hybridization and somatic cell hybrids. Cytogenet Cell Genet. 1998;82:99-100 pubmed
  13. Nakamura Y, Igarashi K, Suzuki T, Kanno J, Inoue T, Tazawa C, et al. E4F1, a novel estrogen-responsive gene in possible atheroprotection, revealed by microarray analysis. Am J Pathol. 2004;165:2019-31 pubmed
    ..b>E4F1, a possible inducer of cell growth arrest, was markedly increased only in ER alpha-positive VSMCs by estrogens in ..
  14. Ro H, Dawid I. Modulation of Tcf3 repressor complex composition regulates cdx4 expression in zebrafish. EMBO J. 2011;30:2894-907 pubmed publisher
    ..Using zebrafish embryos and cultured mammalian cells, we show that the transcription factor E4f1 derepresses cdx4 by dissociating corepressor proteins from Tcf3 without inhibiting its binding to cis-..
  15. Fernandes E, Rooney R. The adenovirus E1A-regulated transcription factor E4F is generated from the human homolog of nuclear factor phiAP3. Mol Cell Biol. 1997;17:1890-903 pubmed
    A 50-kDa cellular factor, E4F, has been implicated in mediating trans activation of the adenovirus E4 gene by the 289R E1A(13S) protein...
  16. Burn T, Connors T, Van Raay T, Dackowski W, Millholland J, Klinger K, et al. Generation of a transcriptional map for a 700-kb region surrounding the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis type 2 (TSC2) disease genes on human chromosome 16p3.3. Genome Res. 1996;6:525-37 pubmed
    ..In this report we present a transcriptional map for the 700 kb of DNA surrounding the PKD1 and TSC2 genes. ..
  17. Cvetanovic M, Rooney R, Garcia J, Toporovskaya N, Zoghbi H, Opal P. The role of LANP and ataxin 1 in E4F-mediated transcriptional repression. EMBO Rep. 2007;8:671-7 pubmed
    ..Here, we report that LANP forms a complex with transcriptional repressor E4F and modulates its activity...
  18. Rooney R, Daniels R, Jenkins N, Gilbert D, Rothammer K, Morris S, et al. Chromosomal location and tissue expression of the gene encoding the adenovirus E1A-regulated transcription factor E4F in humans and mice. Mamm Genome. 1998;9:320-3 pubmed
  19. Legati A, Reyes A, Nasca A, Invernizzi F, Lamantea E, Tiranti V, et al. New genes and pathomechanisms in mitochondrial disorders unraveled by NGS technologies. Biochim Biophys Acta. 2016;1857:1326-1335 pubmed publisher
    ..g. the transcription factor E4F1), an observation that further expands the intricate genetics of mitochondrial disease and suggests a new ..