E2F5

Summary

Gene Symbol: E2F5
Description: E2F transcription factor 5
Alias: E2F-5, transcription factor E2F5, E2F transcription factor 5, p130-binding
Species: human
Products:     E2F5

Top Publications

  1. Apostolova M, Ivanova I, Dagnino C, D Souza S, Dagnino L. Active nuclear import and export pathways regulate E2F-5 subcellular localization. J Biol Chem. 2002;277:34471-9 pubmed
    ..This region excludes the DNA- and the p130-binding domains. Thus, the subcellular distribution of E2F-5 is tightly regulated in intact cells, through multiple functional domains that direct nucleocytoplasmic shuttling of this protein. ..
  2. Chen Q, Liang D, Overbeek P. Overexpression of E2F5/p130, but not E2F5 alone, can inhibit E2F-induced cell cycle entry in transgenic mice. Mol Vis. 2008;14:602-14 pubmed
    The retinoblastoma (Rb) gene family member p130 binds preferentially to the E2F5 transcription factor and forms a repressive E2F5/p130 complex that inhibits cell cycle progression and tumor growth...
  3. Hijmans E, Voorhoeve P, Beijersbergen R, van T Veer L, Bernards R. E2F-5, a new E2F family member that interacts with p130 in vivo. Mol Cell Biol. 1995;15:3082-9 pubmed
    ..E2F-5 resembles the other E2Fs in that it binds to a consensus E2F site in a cooperative fashion with DP-1. By using a specific E2F-5 antiserum, we found that under physiological conditions, E2F-5 interacts preferentially with p130. ..
  4. Chen C, Kang Y, Siegel P, Massague J. E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression. Cell. 2002;110:19-32 pubmed
    ..Smad proteins therefore mediate transcriptional activation or repression depending on their associated partners. ..
  5. Sardet C, Vidal M, Cobrinik D, Geng Y, Onufryk C, Chen A, et al. E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. Proc Natl Acad Sci U S A. 1995;92:2403-7 pubmed
    ..These findings suggest that E2F-4 and E2F-5 may contribute to the regulation of early G1 events including the G0/G1 transition. ..
  6. Macaluso M, Cinti C, Russo G, Russo A, Giordano A. pRb2/p130-E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-alpha in breast cancer. Oncogene. 2003;22:3511-7 pubmed
  7. Gaubatz S, Lindeman G, Ishida S, Jakoi L, Nevins J, Livingston D, et al. E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control. Mol Cell. 2000;6:729-35 pubmed
    ..E2F4 and E2F5 constitute a defined subset of the family...
  8. Ginsberg D, Vairo G, Chittenden T, Xiao Z, Xu G, Wydner K, et al. E2F-4, a new member of the E2F transcription factor family, interacts with p107. Genes Dev. 1994;8:2665-79 pubmed
    ..p107 binding not only can be linked to the regulation of E2F-4 transcriptional activity, but also to suppression of the ability of E2F-4 to transform an immortalized rodent cell line. ..
  9. Lalioti M, Arbi M, Loukas I, Kaplani K, Kalogeropoulou A, Lokka G, et al. GemC1 governs multiciliogenesis through direct interaction and transcriptional regulation of p73. J Cell Sci. 2019;: pubmed publisher
    ..Moreover, we show that GemC1/Lynkeas acts in a trimeric complex with E2F5 and p73 and that this complex is important for the activation of the p73 promoter...

More Information

Publications62

  1. Huang Y, Ning G, Chen L, Lian Y, Gu Y, Wang J, et al. Promising diagnostic and prognostic value of E2Fs in human hepatocellular carcinoma. Cancer Manag Res. 2019;11:1725-1740 pubmed publisher
    ..mutation rate of E2Fs was relatively high in HCC patients, and the DNA sequence alterations primarily occurred in E2F5, E2F3, and E2F6, which were associated with worse overall survival and disease-free survival in HCC patients...
  2. Shiozaki A, Nako Y, Ichikawa D, Konishi H, Komatsu S, Kubota T, et al. Role of the Na ⁺/K ⁺/2Cl⁻ cotransporter NKCC1 in cell cycle progression in human esophageal squamous cell carcinoma. World J Gastroenterol. 2014;20:6844-59 pubmed publisher
    ..pathway was the G2/M DNA damage checkpoint regulation pathway, which involves MAD2L1, DTL, BLM, CDC20, BRCA1, and E2F5. These results suggest that the expression of NKCC1 in ESCC may affect the G2/M checkpoint and may be related to ..
  3. Yu C, Sun J, Leng X, Yang J. Long noncoding RNA SNHG6 functions as a competing endogenous RNA by sponging miR-181a-5p to regulate E2F5 expression in colorectal cancer. Cancer Manag Res. 2019;11:611-624 pubmed publisher
    ..SNHG6 acted as a competing endogenous RNA for miR-181a-5p and attenuated the inhibitory effect of miR-181a-5p on E2F5. Taken together, these results demonstrated that SNHG6 plays a crucial role in CRC progression via miR-181a-5p/E2F5 ..
  4. Liu Y, Liu D, Wan W. MYCN-induced E2F5 promotes neuroblastoma cell proliferation through regulating cell cycle progression. Biochem Biophys Res Commun. 2019;511:35-40 pubmed publisher
    ..The E2F transcription factor 5 (E2F5) plays an oncogenic role in several types of cancer, however, its role in neuroblastoma cells remains poorly ..
  5. Ma L, Quigley I, Omran H, Kintner C. Multicilin drives centriole biogenesis via E2f proteins. Genes Dev. 2014;28:1461-71 pubmed publisher
    ..Here we show that Multicilin acts by forming a ternary complex with E2f4 or E2f5 and Dp1 that binds and activates most of the genes required for centriole biogenesis, while other cell cycle genes ..
  6. Manicum T, Ni F, Ye Y, Fan X, Chen B. Prognostic values of E2F mRNA expression in human gastric cancer. Biosci Rep. 2018;38: pubmed publisher
    ..factors 1 (E2F1), 2 (E2F2) and 3a (E2F3a)) and repressors (E2F3b, E2F transcription factors 4 (E2F4), 5 (E2F5), 6 (E2F6), 7 (E2F7) and 8 (E2F8))...
  7. Kleemann M, Schneider H, Unger K, Bereuther J, Fischer S, Sander P, et al. Induction of apoptosis in ovarian cancer cells by miR-493-3p directly targeting AKT2, STK38L, HMGA2, ETS1 and E2F5. Cell Mol Life Sci. 2019;76:539-559 pubmed publisher
    ..Taken together, our observations have uncovered the apoptosis inducing potential of miR-493-3p through its regulation of multiple target genes participating in the extrinsic and intrinsic apoptosis pathway. ..
  8. Chong Y, Zhang Y, Zhou F, Roy S. Distinct requirements of E2f4 versus E2f5 activity for multiciliated cell development in the zebrafish embryo. Dev Biol. 2018;443:165-172 pubmed publisher
    ..binding domain: they regulate transcription by associating with E2f family transcription factors, notably E2f4 and E2f5. Here, we have studied the relative contribution of these two E2f factors in MCC development using the zebrafish ..
  9. Shike M, Doane A, Russo L, Cabal R, Reis Filho J, Gerald W, et al. The effects of soy supplementation on gene expression in breast cancer: a randomized placebo-controlled study. J Natl Cancer Inst. 2014;106: pubmed publisher
    ..gt;2-fold) of cell cycle transcripts, including those that promote cell proliferation, such as FGFR2, E2F5, BUB1, CCNB2, MYBL2, CDK1, and CDC20 (P < .01)...
  10. Pellatt A, Mullany L, Herrick J, Sakoda L, Wolff R, Samowitz W, et al. The TGFβ-signaling pathway and colorectal cancer: associations between dysregulated genes and miRNAs. J Transl Med. 2018;16:191 pubmed publisher
    ..Eight dysregulated genes were associated with miRNA differential expression. E2F5 and THBS1 were associated with one or two miRNAs; RBL1, TGFBR1, TGIF2, and INHBA were associated with seven or more ..
  11. Li S, Wu H, Yu X, Tang K, Wang S, Ye Z, et al. The putative tumour suppressor miR-1-3p modulates prostate cancer cell aggressiveness by repressing E2F5 and PFTK1. J Exp Clin Cancer Res. 2018;37:219 pubmed publisher
    ..that miR-1-3p could directly target the mRNA 3'- untranslated region (3'- UTR) of two central cell cycle genes, E2F5 and PFTK1, and could suppress their mRNA and protein expression...
  12. Lin C, Hu Z, Yuan G, Su H, Zeng Y, Guo Z, et al. MicroRNA-1179 inhibits the proliferation, migration and invasion of human pancreatic cancer cells by targeting E2F5. Chem Biol Interact. 2018;291:65-71 pubmed publisher
    ..blotting analysis wherein in overexpression of miR-1179 was associated with the downregulation of the expression E2F5. Conversely, silencing of E2F5 had similar effects as that of miR-1179 suppression...
  13. Cito L, Indovina P, Forte I, Pentimalli F, Di Marzo D, Somma P, et al. pRb2/p130 localizes to the cytoplasm in diffuse gastric cancer. J Cell Physiol. 2015;230:802-5 pubmed publisher
    ..has mainly been attributed to its ability to negatively regulate cell cycle by interacting with the E2F4 and E2F5 transcription factors...
  14. Macdonald J, Ramos Valdes Y, Perampalam P, Litovchick L, DiMattia G, Dick F. A Systematic Analysis of Negative Growth Control Implicates the DREAM Complex in Cancer Cell Dormancy. Mol Cancer Res. 2017;15:371-381 pubmed publisher
    ..by loss of some cyclin-dependent kinase inhibitors such as p57Kip2, as well as Dyrk1A, Lin52, and E2F5 in most cell lines tested...
  15. Thomas R, Oleinik N, Panneer Selvam S, Vaena S, Dany M, Nganga R, et al. HPV/E7 induces chemotherapy-mediated tumor suppression by ceramide-dependent mitophagy. EMBO Mol Med. 2017;9:1030-1051 pubmed publisher
    ..Inhibition of RB by HPV-E7 relieves E2F5, which then associates with DRP1, providing a scaffolding platform for Drp1 activation and mitochondrial ..
  16. Arbi M, Pefani D, Kyrousi C, Lalioti M, Kalogeropoulou A, Papanastasiou A, et al. GemC1 controls multiciliogenesis in the airway epithelium. EMBO Rep. 2016;17:400-13 pubmed publisher
    ..GemC1 directly transactivates the McIdas and FoxJ1 upstream regulatory sequences, and its activity is enhanced by E2F5 and inhibited by Geminin. GemC1-knockout mice are born with airway epithelia devoid of multiciliated cells...
  17. Poplawski P, Rybicka B, Boguslawska J, Rodzik K, Visser T, Nauman A, et al. Induction of type 1 iodothyronine deiodinase expression inhibits proliferation and migration of renal cancer cells. Mol Cell Endocrinol. 2017;442:58-67 pubmed publisher
    ..of DIO1 in renal cancer cells changes the expression of genes controlling cell cycle, including cyclin E1 and E2F5, and results in inhibition of proliferation...
  18. Zheng Y, Zhu C, Ma L, Shao P, Qin C, Li P, et al. miRNA-154-5p Inhibits Proliferation, Migration and Invasion by Targeting E2F5 in Prostate Cancer Cell Lines. Urol Int. 2017;98:102-110 pubmed publisher
    ..The effects of forced miR-154-5p expression or E2F transcription factor 5 (E2F5) knockdown on PCa cells were evaluated by cell proliferation, flow cytometry, cell migration and invasion assays as ..
  19. Liban T, Thwaites M, Dick F, Rubin S. Structural Conservation and E2F Binding Specificity within the Retinoblastoma Pocket Protein Family. J Mol Biol. 2016;428:3960-3971 pubmed publisher
    ..In humans, Rb binds E2F1-E2F5, whereas p107 and p130 almost exclusively associate with E2F4 and E2F5...
  20. Fang D, Wang Y, Liu J, Hui X, Wang X, Chen X, et al. MicroRNA-129-3p suppresses tumor growth by targeting E2F5 in glioblastoma. Eur Rev Med Pharmacol Sci. 2018;22:1044-1050 pubmed publisher
    ..Luciferase reporter gene was used to detect target genes of miRNA. E2F5 expression was inhibited by transfection of small interfering RNAs...
  21. Liban T, Medina E, Tripathi S, Sengupta S, Henry R, Buchler N, et al. Conservation and divergence of C-terminal domain structure in the retinoblastoma protein family. Proc Natl Acad Sci U S A. 2017;114:4942-4947 pubmed publisher
    ..A crystal structure of the p107 CTD bound to E2F5 and its dimer partner DP1 reveals the molecular basis for pocket protein-E2F binding specificity and how cyclin-..
  22. Danielian P, Hess R, Lees J. E2f4 and E2f5 are essential for the development of the male reproductive system. Cell Cycle. 2016;15:250-60 pubmed publisher
    ..With the goal of addressing the intestinal requirements of E2f4 and E2f5, we crossed mice carrying Vil-cre, E2f4 conditional and E2f5 germline alleles...
  23. Xie H, Ren X, Xin S, Lan X, Lu G, Lin Y, et al. Emerging roles of circRNA_001569 targeting miR-145 in the proliferation and invasion of colorectal cancer. Oncotarget. 2016;7:26680-91 pubmed publisher
    ..Moreover, hsa_circ_001569 was identified as a sponge of miR-145 and up-regulated miR-145 functional targets E2F5, BAG4 and FMNL2...
  24. Joshi B, Ordonez Ercan D, Dasgupta P, Chellappan S. Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors. Oncogene. 2005;24:2204-17 pubmed
    ..Based on these findings, we conclude that induction of the hMT1G promoter by VEGF and heavy metals occurs through the utilization of different transcription factors. ..
  25. Sun J, Li H, Huo Q, Cui M, Ge C, Zhao F, et al. The transcription factor FOXN3 inhibits cell proliferation by downregulating E2F5 expression in hepatocellular carcinoma cells. Oncotarget. 2016;7:43534-43545 pubmed publisher
    ..Additionally, FOXN3 repressed the mRNA and protein expression of E2F5, a reported potential oncogene, by inhibiting the promoter activity of E2F5...
  26. Umemura S, Shirane M, Takekoshi S, Kusakabe T, Itoh J, Egashira N, et al. Overexpression of E2F-5 correlates with a pathological basal phenotype and a worse clinical outcome. Br J Cancer. 2009;100:764-71 pubmed publisher
    ..This E2F-5-positive breast cancer subtype was associated with an ER(-)/PgR(-)/HER2(-) status, a basal phenotype, and a worse clinical outcome. ..
  27. Litovchick L, Sadasivam S, Florens L, Zhu X, Swanson S, Velmurugan S, et al. Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. Mol Cell. 2007;26:539-51 pubmed
    ..This work reveals an evolutionarily conserved multisubunit protein complex that contains p130 and E2F4, but not pRB, and mediates the repression of cell cycle-dependent genes in quiescence. ..
  28. Teissier S, Pang C, Thierry F. The E2F5 repressor is an activator of E6/E7 transcription and of the S-phase entry in HPV18-associated cells. Oncogene. 2010;29:5061-70 pubmed publisher
    ..Surprisingly, we identified E2F5 as a direct activator of HPV18 E6/E7 transcription by sequential silencing of E2F members in HeLa cells...
  29. Ohtani N, Brennan P, Gaubatz S, Sanij E, Hertzog P, Wolvetang E, et al. Epstein-Barr virus LMP1 blocks p16INK4a-RB pathway by promoting nuclear export of E2F4/5. J Cell Biol. 2003;162:173-83 pubmed
    ..We further demonstrate that LMP1 also blocks the function of E2F4 and E2F5 (E2F4/5) transcription factors through promoting their nuclear export in a CRM1-dependent manner...
  30. Ishimoto T, Shiozaki A, Ichikawa D, Fujiwara H, Konishi H, Komatsu S, et al. E2F5 as an independent prognostic factor in esophageal squamous cell carcinoma. Anticancer Res. 2013;33:5415-20 pubmed
    E2F Transcription Factor 5 Protein (E2F5) is considered to act primarily as a transcriptional repressor in the cell cycle. However, its expression and role in esophageal squamous cell carcinoma (ESCC) have not been investigated...
  31. Jiang Y, Saavedra H, Holloway M, Leone G, Altura R. Aberrant regulation of survivin by the RB/E2F family of proteins. J Biol Chem. 2004;279:40511-20 pubmed
  32. D Souza S, Pajak A, Balazsi K, Dagnino L. Ca2+ and BMP-6 signaling regulate E2F during epidermal keratinocyte differentiation. J Biol Chem. 2001;276:23531-8 pubmed
    ..E2F-5 up-regulation is also accompanied by formation of heteromeric nuclear complexes containing E2F5, p130, and histone deacetylase (HDAC) 1...
  33. Beijersbergen R, Kerkhoven R, Zhu L, Carlee L, Voorhoeve P, Bernards R. E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo. Genes Dev. 1994;8:2680-90 pubmed
    ..We show that expression of E2F-4 and DP-1 together with an activated ras oncogene in rat embryo fibroblasts, causes transformation, indicating that E2F-4 has oncogenic activity. ..
  34. Kothandaraman N, Bajic V, Brendan P, Huak C, Keow P, Razvi K, et al. E2F5 status significantly improves malignancy diagnosis of epithelial ovarian cancer. BMC Cancer. 2010;10:64 pubmed publisher
    ..and experimental approaches (tissue microarray and western blotting on patient samples) we identified and evaluated E2F5 transcription factor involved in cell proliferation, as a promising candidate regulatory target in early stage ..
  35. Vaishnav Y, Vaishnav M, Pant V. The molecular and functional characterization of E2F-5 transcription factor. Biochem Biophys Res Commun. 1998;242:586-92 pubmed
    ..We have also demonstrated the presence of a strong transactivation domain at the carboxy terminus (273-346 amino acid residues) of E2F-5 protein. ..
  36. Kropp J, Degerny C, Morozova N, Pontis J, Harel Bellan A, Polesskaya A. miR-98 delays skeletal muscle differentiation by down-regulating E2F5. Biochem J. 2015;466:85-93 pubmed publisher
    ..We conclude that miR-98 regulates muscle differentiation by altering the expression of the transcription factor E2F5 and, in turn, of multiple E2F5 targets.
  37. Chestukhin A, Litovchick L, Rudich K, DeCaprio J. Nucleocytoplasmic shuttling of p130/RBL2: novel regulatory mechanism. Mol Cell Biol. 2002;22:453-68 pubmed
    ..A model suggesting that the activity of pRb family members can be regulated by intracellular trafficking of the proteins is proposed. ..
  38. Chouraki V, De Bruijn R, Chapuis J, Bis J, Reitz C, Schraen S, et al. A genome-wide association meta-analysis of plasma A? peptides concentrations in the elderly. Mol Psychiatry. 2014;19:1326-35 pubmed publisher
    ..In conclusion, our study results suggest that plasma A? peptides levels are valid endophenotypes in GWASs and can be used to characterize the metabolism and functions of APP and its metabolites. ..
  39. Itoh A, Levinson S, Morita T, Kourembanas S, Brody J, Mitsialis S. Structural characterization and specificity of expression of E2F-5: a new member of the E2F family of transcription factors. Cell Mol Biol Res. 1995;41:147-54 pubmed
    ..The structural divergence between the two branches of the E2F family may thus reflect participation in different regulatory networks. ..
  40. Swetloff A, Ferretti P. Changes in E2F5 intracellular localization in mouse and human choroid plexus epithelium with development. Int J Dev Biol. 2005;49:859-65 pubmed
    ..It has been recently shown that mice lacking functional transcription factors, E2F5, foxJ1 or p73, develop non-obstructive hydrocephalus likely due to CPe dysfunction...
  41. Lu G, Sun Y, An S, Xin S, Ren X, Zhang D, et al. MicroRNA-34a targets FMNL2 and E2F5 and suppresses the progression of colorectal cancer. Exp Mol Pathol. 2015;99:173-9 pubmed publisher
    ..Moreover, ectopic miR-34a suppressed tumor growth and metastasis of CRC cells in vivo. FMNL2 and E2F5 were identified as direct targets of miR-34a...
  42. Rubin S, Gall A, Zheng N, Pavletich N. Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release. Cell. 2005;123:1093-106 pubmed
    ..Our findings explain the requirement of RbC for high-affinity E2F binding and growth suppression and establish a mechanism for the regulation of Rb-E2F association by phosphorylation. ..
  43. Takeda S, Chen D, Westergard T, Fisher J, Rubens J, Sasagawa S, et al. Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression. Genes Dev. 2006;20:2397-409 pubmed
    ..Lastly, Taspase1(-/-) cells are resistant to oncogenic transformation, and Taspase1 is overexpressed in many cancer cell lines. Thus, Taspase1 may serve as a target for cancer therapeutics. ..
  44. Kong L, Meloni A, Nevins J. The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1. Mol Cell. 2006;22:63-71 pubmed
    ..Given previous work implicating E2F in the control of telomerase gene expression, these results thus point to complementary roles for the Rb/E2F pathway in the control of telomere length. ..
  45. Cai C, Huo Q, Wang X, Chen B, Yang Q. SNHG16 contributes to breast cancer cell migration by competitively binding miR-98 with E2F5. Biochem Biophys Res Commun. 2017;485:272-278 pubmed publisher
    ..We predicted SNHG16 as a competitive endogenous RNA (ceRNA) of E2F transcription factor 5 protein (E2F5) via competition for the shared miR-98 through bioinformatics analysis, and proved this regulation using relative ..
  46. Zhao J, Wu X, Ling X, Lin Z, Fu X, Deng Y, et al. Analysis of genetic aberrations on chromosomal region 8q21-24 identifies E2F5 as an oncogene with copy number gain in prostate cancer. Med Oncol. 2013;30:465 pubmed publisher
    ..Moreover, the clinical significance of candidate markers (MYC and E2F5) in PCa were further determined...
  47. Morris L, Allen K, La Thangue N. Regulation of E2F transcription by cyclin E-Cdk2 kinase mediated through p300/CBP co-activators. Nat Cell Biol. 2000;2:232-9 pubmed
    ..These results indicate that E2F activity may be directly regulated by cyclin E-Cdk2, and imply an autoregulatory mechanism for cell-cycle-dependent transcription through the CDK-stimulated interaction of E2F with p300/CBP co-activators. ..
  48. Majumder S, Bhowal A, Basu S, Mukherjee P, Chatterji U, Sengupta S. Deregulated E2F5/p38/SMAD3 Circuitry Reinforces the Pro-Tumorigenic Switch of TGF? Signaling in Prostate Cancer. J Cell Physiol. 2016;231:2482-92 pubmed publisher
    ..b>E2F5 was identified as one of the most deregulated genes in prostate cancer tissues, predominantly in samples with ..
  49. Lindeman G, Gaubatz S, Livingston D, Ginsberg D. The subcellular localization of E2F-4 is cell-cycle dependent. Proc Natl Acad Sci U S A. 1997;94:5095-100 pubmed
    ..Thus, the subcellular location of E2F-4 is regulated in a cell cycle-dependent manner, providing another potential mechanism for its functional regulation. ..
  50. Connell Crowley L, Harper J, Goodrich D. Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation. Mol Biol Cell. 1997;8:287-301 pubmed
    ..This study identifies a residue whose phosphorylation is critical for inactivation of pRb-mediated growth suppression, and it indicates that hyperphosphorylation and inactivation of pRb are not necessarily synonymous. ..
  51. Jiang Y, Yim S, Xu H, Jung S, Yang S, Hu H, et al. A potential oncogenic role of the commonly observed E2F5 overexpression in hepatocellular carcinoma. World J Gastroenterol. 2011;17:470-7 pubmed publisher
    To explore the expression pattern of E2F5 in primary hepatocellular carcinomas (HCCs) and elucidate the roles of E2F5 in hepatocarcinogenesis...
  52. Zou C, Li Y, Cao Y, Zhang J, Jiang J, Sheng Y, et al. Up-regulated MicroRNA-181a induces carcinogenesis in hepatitis B virus-related hepatocellular carcinoma by targeting E2F5. BMC Cancer. 2014;14:97 pubmed publisher
    ..Mechanism investigation revealed that miR-181a inhibited the expression of transcription factor E2F5 by specifically targeting its mRNA 3'UTR...
  53. Zhang Y, Zhu X, Zhu X, Wu Y, Liu Y, Yao B, et al. MiR-613 suppresses retinoblastoma cell proliferation, invasion, and tumor formation by targeting E2F5. Tumour Biol. 2017;39:1010428317691674 pubmed publisher
    ..We further identified E2F5 as a direct target of miR-613...