E2F3

Summary

Gene Symbol: E2F3
Description: E2F transcription factor 3
Alias: E2F-3, transcription factor E2F3
Species: human
Products:     E2F3

Top Publications

  1. Orlic M, Spencer C, Wang L, Gallie B. Expression analysis of 6p22 genomic gain in retinoblastoma. Genes Chromosomes Cancer. 2006;45:72-82 pubmed
    ..6 Mb minimal region of gain at 6p22 (DEK, AOF1, TPMT, NHLRC1, KIF13A, and NUP153), and E2F3 is 2 Mb away from the minimal region of gain on 6p22...
  2. Chen L, Chen D, Kurtyka C, Rawal B, Fulp W, Haura E, et al. Tripartite motif containing 28 (Trim28) can regulate cell proliferation by bridging HDAC1/E2F interactions. J Biol Chem. 2012;287:40106-18 pubmed publisher
    ..Confocal microscopy indicated co-localization of E2F3 and E2F4 with Trim28 within the cell nucleus, and co-immunoprecipitation assays demonstrated that Trim28 can bind ..
  3. Leone G, Nuckolls F, Ishida S, Adams M, Sears R, Jakoi L, et al. Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins. Mol Cell Biol. 2000;20:3626-32 pubmed
    ..This novel E2F, which we term E2F3b, is encoded by a unique mRNA transcribed from an intronic promoter within the E2F3 locus...
  4. Jiang Y, Saavedra H, Holloway M, Leone G, Altura R. Aberrant regulation of survivin by the RB/E2F family of proteins. J Biol Chem. 2004;279:40511-20 pubmed
    ..We also show that the E2F activators (E2F1, E2F2, and E2F3) can bind to the survivin promoter and induce survivin transcription...
  5. Cooper C, Nicholson A, Foster C, Dodson A, Edwards S, Fletcher A, et al. Nuclear overexpression of the E2F3 transcription factor in human lung cancer. Lung Cancer. 2006;54:155-62 pubmed
    The E2F3 transcription factor has an established role in controlling cell cycle progression...
  6. Hurst C, Tomlinson D, Williams S, Platt F, Knowles M. Inactivation of the Rb pathway and overexpression of both isoforms of E2F3 are obligate events in bladder tumours with 6p22 amplification. Oncogene. 2008;27:2716-27 pubmed
    b>E2F3 and CDKAL1 are candidate genes from the 6p22 region frequently amplified in bladder cancer. Expression of E2F3 isoforms (E2F3a and b) and CDKAL1 were examined and modulated in 6p22-amplified bladder cell lines...
  7. Bilke S, Schwentner R, Yang F, Kauer M, Jug G, Walker R, et al. Oncogenic ETS fusions deregulate E2F3 target genes in Ewing sarcoma and prostate cancer. Genome Res. 2013;23:1797-809 pubmed publisher
    ..Supported by promoter activity and mutation analyses, we demonstrate that a large fraction of E2F3 target genes are synergistically coregulated by these aberrant ETS proteins...
  8. Danielian P, Friesenhahn L, Faust A, West J, Caron A, Bronson R, et al. E2f3a and E2f3b make overlapping but different contributions to total E2f3 activity. Oncogene. 2008;27:6561-70 pubmed publisher
    ..b>E2F3 has garnered particular attention because it is amplified in various human tumors...
  9. Lui J, Baron J. Evidence that Igf2 down-regulation in postnatal tissues and up-regulation in malignancies is driven by transcription factor E2f3. Proc Natl Acad Sci U S A. 2013;110:6181-6 pubmed publisher
    ..We found evidence that E2F transcription factor 3 (E2F3) drives these changes in expression...

More Information

Publications122 found, 100 shown here

  1. Humbert P, Verona R, Trimarchi J, Rogers C, Dandapani S, Lees J. E2f3 is critical for normal cellular proliferation. Genes Dev. 2000;14:690-703 pubmed
    ..To establish the role of E2F3 in vivo, we generated an E2f3 mutant mouse strain...
  2. Chen H, Tsai S, Leone G. Emerging roles of E2Fs in cancer: an exit from cell cycle control. Nat Rev Cancer. 2009;9:785-97 pubmed publisher
  3. Pulikkan J, Peramangalam P, Dengler V, Ho P, Preudhomme C, Meshinchi S, et al. C/EBP? regulated microRNA-34a targets E2F3 during granulopoiesis and is down-regulated in AML with CEBPA mutations. Blood. 2010;116:5638-49 pubmed publisher
    ..During granulopoiesis, miR-34a targets E2F3 and blocks myeloid cell proliferation...
  4. Leone G, DeGregori J, Yan Z, Jakoi L, Ishida S, Williams R, et al. E2F3 activity is regulated during the cell cycle and is required for the induction of S phase. Genes Dev. 1998;12:2120-30 pubmed
    ..whereas overall E2F DNA-binding activity accumulates during the initial G1 following a growth stimulus, only E2F3-binding activity reaccumulates at subsequent G1/S transitions, coincident with the expression of the cell-cycle-..
  5. Takahashi Y, Rayman J, Dynlacht B. Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression. Genes Dev. 2000;14:804-16 pubmed
    ..These findings suggest that repression and activation of E2F-responsive genes may occur through distinct E2F heterodimers that direct the sequential recruitment of enzymes able to deacetylate and then acetylate core histones. ..
  6. Adams M, Sears R, Nuckolls F, Leone G, Nevins J. Complex transcriptional regulatory mechanisms control expression of the E2F3 locus. Mol Cell Biol. 2000;20:3633-9 pubmed
    ..We have shown that the E2F3 locus encodes two protein products: the E2F3a product, which is tightly regulated by cell growth, and the E2F3b ..
  7. Feng B, Wang R, Song H, Chen L. MicroRNA-200b reverses chemoresistance of docetaxel-resistant human lung adenocarcinoma cells by targeting E2F3. Cancer. 2012;118:3365-76 pubmed publisher
    ..We also identified E2F3 as a novel target of miR-200b...
  8. He Y, Armanious M, Thomas M, Cress W. Identification of E2F-3B, an alternative form of E2F-3 lacking a conserved N-terminal region. Oncogene. 2000;19:3422-33 pubmed
    ..These observations make E2F-3B the first example of an E2F gene giving rise to two different protein species and also suggest that E2F-3 and E2F-3B may have opposing roles in cell cycle control. ..
  9. Tordai A, Wang J, Andre F, Liedtke C, Yan K, Sotiriou C, et al. Evaluation of biological pathways involved in chemotherapy response in breast cancer. Breast Cancer Res. 2008;10:R37 pubmed publisher
    ..1), the genomic grade index (FDR q = 0.044), and the E2F3 pathway signature (FDR q = 0.22, P = 0.07) were enriched in the pCR group...
  10. Grasemann C, Gratias S, Stephan H, Schuler A, Schramm A, Klein Hitpass L, et al. Gains and overexpression identify DEK and E2F3 as targets of chromosome 6p gains in retinoblastoma. Oncogene. 2005;24:6441-9 pubmed
    ..The remaining 20 (26%) samples showed gains only at some loci, most often including E2F3 and DEK in 6p22.3...
  11. Folk W, Kumari A, Iwasaki T, Pyndiah S, Johnson J, Cassimere E, et al. Loss of the tumor suppressor BIN1 enables ATM Ser/Thr kinase activation by the nuclear protein E2F1 and renders cancer cells resistant to cisplatin. J Biol Chem. 2019;294:5700-5719 pubmed publisher
    ..However, E2F2 or E2F3 depletion did not recapitulate the cisplatin sensitivity elicited by E2F1 elimination...
  12. Tagne J, Gupta S, Gower A, Shen S, Varma S, Lakshminarayanan M, et al. Genome-wide analyses of Nkx2-1 binding to transcriptional target genes uncover novel regulatory patterns conserved in lung development and tumors. PLoS ONE. 2012;7:e29907 pubmed publisher
    ..New targets, validated in Nkx2-1 shRNA transduced cell lines, include E2f3, Cyclin B1, Cyclin B2, and c-Met...
  13. Li Q, Li C, Chen J, Liu P, Cui Y, Zhou X, et al. High expression of long noncoding RNA NORAD indicates a poor prognosis and promotes clinical progression and metastasis in bladder cancer. Urol Oncol. 2018;36:310.e15-310.e22 pubmed publisher
    ..that knockdown of NORAD results in lower proliferation in TSSCUP cells, whereas PUM2 expression was upregulated and E2F3 downregulated...
  14. Gao L, He R, Wu H, Zhang T, Liang H, Ye Z, et al. Expression Signature and Role of miR-30d-5p in Non-Small Cell Lung Cancer: a Comprehensive Study Based on in Silico Analysis of Public Databases and in Vitro Experiments. Cell Physiol Biochem. 2018;50:1964-1987 pubmed publisher
    ..Among the 12 identified hub genes, nine genes including E2F3, CCNE2, SKP2, CDK6, TFDP1, LDHA, GOT2, DNMT3B and ST6GALNAC1 were validated by Pearson's correlation test and the ..
  15. Niu Z, Liu H, Zhou M, Wang H, Liu Y, Li X, et al. Knockdown of c-Myc inhibits cell proliferation by negatively regulating the Cdk/Rb/E2F pathway in nasopharyngeal carcinoma cells. Acta Biochim Biophys Sin (Shanghai). 2015;47:183-91 pubmed publisher
    ..expression of several critical molecules involved in the Cdk/Rb/E2F pathway, including CDK4, cyclin D1, CDK2, pRb, E2F3, and DP2, and significantly reduced the promoter activity of cyclin D1...
  16. Zhu X, Enomoto K, Zhao L, Zhu Y, Willingham M, Meltzer P, et al. Bromodomain and Extraterminal Protein Inhibitor JQ1 Suppresses Thyroid Tumor Growth in a Mouse Model. Clin Cancer Res. 2017;23:430-440 pubmed publisher
    ..Analyses showed that JQ1 decreased MYC abundance in thyroid tumors and attenuated the cyclin D1-CDK4-Rb-E2F3 signaling to decrease tumor growth...
  17. Rajamani D, Bhasin M. Identification of key regulators of pancreatic cancer progression through multidimensional systems-level analysis. Genome Med. 2016;8:38 pubmed publisher
    ..Systems-level analysis of the scale-free GMCs network identified eight potential key regulator hubs, namely E2F3, HMGA2, RASA1, IRS1, NUAK1, ACTN1, SKI and DLL1, associated with important pathways driving cancer progression...
  18. Manicum T, Ni F, Ye Y, Fan X, Chen B. Prognostic values of E2F mRNA expression in human gastric cancer. Biosci Rep. 2018;38: pubmed publisher
    ..Our result demonstrated that high expressions of three family members of E2F (E2F1, E2F3, E2F4) mRNA were significantly associated with unfavourable OS in all GC patients...
  19. Farra R, Dapas B, Baiz D, Tonon F, Chiaretti S, Del Sal G, et al. Impairment of the Pin1/E2F1 axis in the anti-proliferative effect of bortezomib in hepatocellular carcinoma cells. Biochimie. 2015;112:85-95 pubmed publisher
    ..Moreover, Pin1-E2F1 promote HuH7 growth via the up-regulation of cyclin D1, cyclin E, cyclin A2, E2F2 and in part E2F3. Finally, in the control cells IHH and hPSC-H, BZB effect on cell vitality is not irrelevant, a fact correlated to ..
  20. Huang Y, Ning G, Chen L, Lian Y, Gu Y, Wang J, et al. Promising diagnostic and prognostic value of E2Fs in human hepatocellular carcinoma. Cancer Manag Res. 2019;11:1725-1740 pubmed publisher
    ..rate of E2Fs was relatively high in HCC patients, and the DNA sequence alterations primarily occurred in E2F5, E2F3, and E2F6, which were associated with worse overall survival and disease-free survival in HCC patients...
  21. Cui H, Ge J, Xie N, Banerjee S, Zhou Y, Liu R, et al. miR-34a promotes fibrosis in aged lungs by inducing alveolarepithelial dysfunctions. Am J Physiol Lung Cell Mol Physiol. 2017;312:L415-L424 pubmed publisher
    ..We found that miR-34a targeted Sirt1, a master anti-aging regulator, and two key cell cycle modulators, E2F3 and cyclin E2, in lung epithelial cells, and the repression of these targets was relieved in miR-34a-deficient AECs...
  22. Guo W, Lian S, Guo J, Zhai J, Zhang Y, Li Y, et al. [Biological function prediction of mir-210 in the liver of acute cold stress rat]. Sheng Li Xue Bao. 2016;68:165-70 pubmed
    ..analysis showed that mir-210 has over hundreds of target genes and four kinds of target genes such as E2F3, RAD52, ISCU and Ephrin-A3 are more relative with liver cold stress...
  23. Gao Z, Shi R, Yuan K, Wang Y. Expression and prognostic value of E2F activators in NSCLC and subtypes: a research based on bioinformatics analysis. Tumour Biol. 2016;37:14979-14987 pubmed
    ..E2F1 and E2F2 overexpression showed a significant association with poor prognosis, while E2F3 overexpression was significantly correlated to better prognosis...
  24. Zhu L, Feng H, Jin S, Tan M, Gao S, Zhuang H, et al. High expressions of BCL6 and Lewis y antigen are correlated with high tumor burden and poor prognosis in epithelial ovarian cancer. Tumour Biol. 2017;39:1010428317711655 pubmed publisher
    ..including four upregulated genes ( SOCS3, STAT1, PPARG, and GADD45A) and three downregulated genes ( ACAN, E2F3, and ZBTB7B)...
  25. Liu Z, Bi X, Liu P, Lei D, Wang Y, Li Z, et al. Expressions and prognostic values of the E2F transcription factors in human breast carcinoma. Cancer Manag Res. 2018;10:3521-3532 pubmed publisher
    ..plotting the survival curve in the Kaplan-Meier Plotter, it was found that higher mRNA levels of E2F1, E2F3, E2F7, and E2F8 were associated with poorer relapse-free survival in all BC patients, indicating ..
  26. Maurus K, Hufnagel A, Geiger F, Graf S, Berking C, Heinemann A, et al. The AP-1 transcription factor FOSL1 causes melanocyte reprogramming and transformation. Oncogene. 2017;36:5110-5121 pubmed publisher
    ..Furthermore, FOSL1 re-enforced pro-tumorigenic transcription factors MYC, E2F3 and AP-1...
  27. Shivakumar M, Lee Y, Bang L, Garg T, Sohn K, Kim D. Identification of epigenetic interactions between miRNA and DNA methylation associated with gene expression as potential prognostic markers in bladder cancer. BMC Med Genomics. 2017;10:30 pubmed publisher
    ..Then, 11 significant epigenetic interactions between miRNA and methylation, which target E2F3, CCND1, UTP6, CDADC1, SLC35E3, METRNL, TPCN2, NACC2, VGLL4, and PTEN, were found to be associated with survival...
  28. Iwahori S, Kalejta R. Phosphorylation of transcriptional regulators in the retinoblastoma protein pathway by UL97, the viral cyclin-dependent kinase encoded by human cytomegalovirus. Virology. 2017;512:95-103 pubmed publisher
    ..repressive DREAM complexes that control transcription during the G0/G1 phases, and the Rb-associated E2F3 protein that activates transcription through G1 and S phases...
  29. Nakaoka T, Saito Y, Shimamoto Y, Muramatsu T, Kimura M, Kanai Y, et al. Cluster microRNAs miR-194 and miR-215 suppress the tumorigenicity of intestinal tumor organoids. Cancer Sci. 2017;108:678-684 pubmed publisher
    ..Enforced expression of miR-194 resulted in inhibition of E2f3, a positive regulator of the cell cycle and growth suppression of intestinal tumor organoids...
  30. Meng Y, Cai X, Wang L. Potential Genes and Pathways of Neonatal Sepsis Based on Functional Gene Set Enrichment Analyses. Comput Math Methods Med. 2018;2018:6708520 pubmed publisher
    ..Among those genes involved in key pathways, 7 hub genes, PIK3CA, TGFBR2, CDKN1B, KRAS, E2F3, TRAF6, and CHUK, were determined based on the coexpression network. Most of them were cancer-related genes...
  31. Wu S, Wu F, Jiang Z. Identification of hub genes, key miRNAs and potential molecular mechanisms of colorectal cancer. Oncol Rep. 2017;38:2043-2050 pubmed publisher
    ..A total of eight genes were identified as biomarkers, including CAD, ITGA2, E2F3, BCL2, PRKACB, IGF1, SGK1 and NR3C1...
  32. Song P, Ye L, Zhang C, Peng T, Zhou X. Long non-coding RNA XIST exerts oncogenic functions in human nasopharyngeal carcinoma by targeting miR-34a-5p. Gene. 2016;592:8-14 pubmed publisher
    ..Additionally, mechanistic analysis revealed that XIST up-regulated the expression of miR-34a-5p targeted gene E2F3 through acting as a competitive 'sponge' of miR-34a-5p...
  33. Cui Y, Yang X, Zhang X. Shrimp miR-34 from Shrimp Stress Response to Virus Infection Suppresses Tumorigenesis of Breast Cancer. Mol Ther Nucleic Acids. 2017;9:387-398 pubmed publisher
    ..cells and in mice suppressed the growth and metastasis of breast cancer by targeting human CCND1, CDK6, CCNE2, E2F3, FOSL1, and MET genes in a cross-phylum manner...
  34. Ki S, Park D, Selden H, Seita J, Chung H, Kim J, et al. Global transcriptional profiling reveals distinct functions of thymic stromal subsets and age-related changes during thymic involution. Cell Rep. 2014;9:402-15 pubmed publisher
    ..transcriptional signature of early thymic involution is decreased expression of cell-cycle-associated genes and E2F3 transcriptional targets in thymic epithelial subsets...
  35. O Bryant D, Wang Z. The essential role of WD repeat domain 77 in prostate tumor initiation induced by Pten loss. Oncogene. 2018;37:4151-4163 pubmed publisher
    ..Mechanistically, Wdr77 ablation inhibited E2F3 activation and enhanced TGFβ signaling, leading to attenuated cellular proliferation induced by loss of Pten...
  36. Wang F, Chan L, Cho W, Tang P, Yu J, Shyu C, et al. Novel approach for coexpression analysis of E2F1-3 and MYC target genes in chronic myelogenous leukemia. Biomed Res Int. 2014;2014:439840 pubmed publisher
    ..Our findings may be helpful in exploring the underlying mechanisms of CML and provide useful information in cancer treatment. ..
  37. Bian W, Shi P, Mi X, Sun Y, Yang D, Gao B, et al. MiR-210 protects cardiomyocytes from OGD/R injury by inhibiting E2F3. Eur Rev Med Pharmacol Sci. 2018;22:743-749 pubmed publisher
    ..At the same time, changes in mRNA and protein expressions of E2F3 were detected by RT-PCR and Western blotting, respectively...
  38. Weinmann A, Yan P, Oberley M, Huang T, Farnham P. Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis. Genes Dev. 2002;16:235-44 pubmed
    ..We suggest that human CpG microarrays, in combination with chromatin immunoprecipitation, will allow rapid identification of target promoters for many mammalian transcription factors. ..
  39. Reimer D, Hubalek M, Riedle S, Skvortsov S, Erdel M, Concin N, et al. E2F3a is critically involved in epidermal growth factor receptor-directed proliferation in ovarian cancer. Cancer Res. 2010;70:4613-23 pubmed publisher
  40. Park S, PLATT J, Lee J, Lopez Giraldez F, Herbst R, Koo J. E2F8 as a Novel Therapeutic Target for Lung Cancer. J Natl Cancer Inst. 2015;107: pubmed publisher
    The E2F members have been divided into transcription activators (E2F1-E2F3) and repressors (E2F4-E2F8)...
  41. Benavente C, Finkelstein D, Johnson D, Marine J, Ashery Padan R, Dyer M. Chromatin remodelers HELLS and UHRF1 mediate the epigenetic deregulation of genes that drive retinoblastoma tumor progression. Oncotarget. 2014;5:9594-608 pubmed
    ..In Rb;p107-deficient retinae, E2f1 and E2f3 inactivation rescued tumor formation but only E2f1 rescued the retinal development phenotype...
  42. Kent L, Bae S, Tsai S, Tang X, Srivastava A, Koivisto C, et al. Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma. J Clin Invest. 2017;127:830-842 pubmed publisher
    ..In this work, a mutation analysis of human cancer revealed subtle but impactful copy number gains in E2F1 and E2F3 in hepatocellular carcinoma (HCC)...
  43. Qiu M, Liang Z, Chen L, Tan G, Wang K, Liu L, et al. MicroRNA-429 suppresses cell proliferation, epithelial-mesenchymal transition, and metastasis by direct targeting of BMI1 and E2F3 in renal cell carcinoma. Urol Oncol. 2015;33:332.e9-18 pubmed publisher
    ..regions of B-cell-specific Moloney murine leukemia virus insertion site 1 (BMI1) and E2F transcription factor 3 (E2F3) transcripts, regulating their expression, as well as that of the downstream epithelial-to-mesenchymal transition ..
  44. Chaussepied M, Ginsberg D. Transcriptional regulation of AKT activation by E2F. Mol Cell. 2004;16:831-7 pubmed
    ..AKT activation was shown to inhibit E2F1induced apoptosis. Therefore, our results suggest the existence of a negative feedback loop involving E2F and AKT. ..
  45. Hu C, Du P, Zhang H, Huang G. Long Noncoding RNA CRNDE Promotes Proliferation of Gastric Cancer Cells by Targeting miR-145. Cell Physiol Biochem. 2017;42:13-21 pubmed publisher
    ..CRNDE and miR-145 expression were assayed by qRT-PCR, and E2F3 protein expression was measured by western blotting...
  46. Pegolo S, Dadousis C, Mach N, Ramayo Caldas Y, Mele M, Conte G, et al. SNP co-association and network analyses identify E2F3, KDM5A and BACH2 as key regulators of the bovine milk fatty acid profile. Sci Rep. 2017;7:17317 pubmed publisher
    ..Analysis of transcription factors and their putative target genes within the network identified BACH2, E2F3 and KDM5A as key regulators of milk FA metabolism...
  47. Wu C, Zukerberg L, Ngwu C, Harlow E, Lees J. In vivo association of E2F and DP family proteins. Mol Cell Biol. 1995;15:2536-46 pubmed
    ..However, the various E2F/DP complexes display strong differences in the ability to bind to either pRB or p107 in vivo, and the specificity of pRB or p107 binding is mediated by the E2F subunit. ..
  48. Giangrande P, Hallstrom T, Tunyaplin C, Calame K, Nevins J. Identification of E-box factor TFE3 as a functional partner for the E2F3 transcription factor. Mol Cell Biol. 2003;23:3707-20 pubmed
    ..provide a mechanistic basis for the specificity of E2F function, we identified the E-box binding factor TFE3 as an E2F3-specific partner. We also show that this interaction is dependent on the marked box domain of E2F3...
  49. Foster C, Falconer A, Dodson A, Norman A, Dennis N, Fletcher A, et al. Transcription factor E2F3 overexpressed in prostate cancer independently predicts clinical outcome. Oncogene. 2004;23:5871-9 pubmed
    E2F transcription factors, including E2F3, directly modulate expression of EZH2. Recently, overexpression of the EZH2 gene has been implicated in the development of human prostate cancer...
  50. Noguchi S, Mori T, Otsuka Y, Yamada N, Yasui Y, Iwasaki J, et al. Anti-oncogenic microRNA-203 induces senescence by targeting E2F3 protein in human melanoma cells. J Biol Chem. 2012;287:11769-77 pubmed publisher
    ..A microRNA target database predicted E2F3 and ZBP-89 as putative targets of microRNA-203 (miR-203)...
  51. Gou D, Ramchandran R, Peng X, Yao L, Kang K, Sarkar J, et al. miR-210 has an antiapoptotic effect in pulmonary artery smooth muscle cells during hypoxia. Am J Physiol Lung Cell Mol Physiol. 2012;303:L682-91 pubmed publisher
    ..We found that miR-210 appears to mediate its antiapoptotic effects via the regulation of transcription factor E2F3, a direct target of miR-210...
  52. Xu Y, Huang Z, Liu Y. Reduced miR-125a-5p expression is associated with gastric carcinogenesis through the targeting of E2F3. Mol Med Rep. 2014;10:2601-8 pubmed publisher
    ..of miR-125a-5p repressed the activity of a luciferase reporter carrying the 3'-untranslated (3'-UTR) region of E2F3, which was eliminated by mutation of the predicted miR-125a-binding site, indicating that E2F3 may be a potential ..
  53. Karlseder J, Rotheneder H, Wintersberger E. Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F. Mol Cell Biol. 1996;16:1659-67 pubmed
    ..For this interaction, the C-terminal part of Sp1 and the N terminus of E2F1, a domain also present in E2F2 and E2F3 but absent in E2F4 and E2F5, were essential...
  54. Magae J, Wu C, Illenye S, Harlow E, Heintz N. Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members. J Cell Sci. 1996;109 ( Pt 7):1717-26 pubmed
    ..These results indicate that DP proteins preferentially associate with specific E2F partners, and suggest that the ability of specific E2F/DP heterodimers to localize in the nucleus contributes to the regulation of E2F activity. ..
  55. Qiu M, Liang Z, Chen L, Tan G, Liu L, Wang K, et al. MicroRNA-200c suppresses cell growth and metastasis by targeting Bmi-1 and E2F3 in renal cancer cells. Exp Ther Med. 2017;13:1329-1336 pubmed publisher
    ..oncogenes B-cell-specific Moloney murine leukemia virus insertion site 1 (Bmi-1) and E2F transcription factor 3 (E2F3) mRNAs, reduced the expression of Bmi-1 and E2F3 and regulated the expression of downstream genes, including E-..
  56. Liao Y, Du W. Rb-independent E2F3 promotes cell proliferation and alters expression of genes involved in metabolism and inflammation. FEBS Open Bio. 2017;7:1611-1621 pubmed publisher
    ..Characterization of mouse embryonic fibroblasts with this Rb-independent E2F3LQ mutation revealed that disrupting the Rb and E2F3 interaction increased cell proliferation, allowed ..
  57. Eiring A, Neviani P, Santhanam R, Oaks J, Chang J, Notari M, et al. Identification of novel posttranscriptional targets of the BCR/ABL oncoprotein by ribonomics: requirement of E2F3 for BCR/ABL leukemogenesis. Blood. 2008;111:816-28 pubmed
    ..Interestingly, we found that the mRNA encoding the transcription factor E2F3 associates to hnRNP-A1 through a conserved binding site located in the E2F3 3' untranslated region (UTR)...
  58. Fushimi K, Uzawa K, Ishigami T, Yamamoto N, Kawata T, Shibahara T, et al. Susceptible genes and molecular pathways related to heavy ion irradiation in oral squamous cell carcinoma cells. Radiother Oncol. 2008;89:237-44 pubmed publisher
    ..Among the genes, three genes (TGFBR2, SMURF2, and BMP7) and two genes (CCND1 and E2F3), respectively, were found to be involved in the transforming growth factor beta-signaling pathway and cell cycle:..
  59. Su J, Wang Q, Liu Y, Zhong M. miR-217 inhibits invasion of hepatocellular carcinoma cells through direct suppression of E2F3. Mol Cell Biochem. 2014;392:289-96 pubmed publisher
    ..Mechanically, bioinformatics analysis combined with experimental analysis demonstrated E2F3 was a novel direct target of miR-217...
  60. Liu H, Tang X, Srivastava A, Pécot T, Daniel P, Hemmelgarn B, et al. Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles. Nat Cell Biol. 2015;17:1036-48 pubmed publisher
    ..Surprisingly, Rb deficiency results in the Myc-dependent accumulation of E2f3 protein and chromatin repositioning of both Myc and E2f3, leading to the 'super activation' of a G1-S ..
  61. Fujii T, Shimada K, Tatsumi Y, Hatakeyama K, Obayashi C, Fujimoto K, et al. microRNA-145 promotes differentiation in human urothelial carcinoma through down-regulation of syndecan-1. BMC Cancer. 2015;15:818 pubmed publisher
    ..Syndecan-1 expression diminished, whereas stem cell markers such as SOX2, NANOG, OCT4, and E2F3 increased...
  62. Yang Y, Chang S, Zhao Z, Hou N, He K, Wang X, et al. MicroRNA-214 suppresses the proliferation of human hepatocellular carcinoma cells by targeting E2F3. Oncol Lett. 2015;10:3779-3784 pubmed
    ..study, miR-214 was observed to suppress tumor proliferation by directly targeting E2F transcription factor 3 (E2F3) in HCC cells...
  63. Cabello P, Pineda B, Tormo E, Lluch A, Eroles P. The Antitumor Effect of Metformin Is Mediated by miR-26a in Breast Cancer. Int J Mol Sci. 2016;17: pubmed publisher
    ..Similarly, the expression levels of the miR-26a targets CASP3, CCNE2, ABL2, APAF1, XIAP, BCL-2, PTEN, p53, E2F3, CDC25A, BCL2L1, MCL-1, EZH2, and MTDH were assessed by quantitative polymerase chain reaction (PCR)...
  64. Tang Z, Liu N, Luo L, Kang K, Li L, Ni R, et al. MicroRNA-17-92 Regulates the Transcription Factor E2F3b during Myogenesis In Vitro and In Vivo. Int J Mol Sci. 2017;18: pubmed publisher
    ..bioinformatics to combine the database of microRNAs downregulated during myogenesis and those predicted to target E2F3. This identified miR-17 and miR-20a as miRNAs potentially involved in E2F3 regulation...
  65. Gan M, Du J, Shen L, Yang D, Jiang A, Li Q, et al. miR-152 regulates the proliferation and differentiation of C2C12 myoblasts by targeting E2F3. In Vitro Cell Dev Biol Anim. 2018;54:304-310 pubmed publisher
    ..Moreover, over-expression of miR-152 significantly decreased E2F3 production in C2C12 myoblasts. A luciferase assay confirmed that miR-152 could bind to the 3' UTR of E2F3...
  66. Hofmann F, Livingston D. Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit. Genes Dev. 1996;10:851-61 pubmed
    ..Cdk3 bound specifically to E2F-1/DP-1 complexes in vivo, most likely through DP-1. Thus, cdk3 function contributes to the activation of E2F-1, E2F-2, and partially E2F-3 and, thereby, participates in the process of S-phase entry. ..
  67. Ianari A, Natale T, Calo E, Ferretti E, Alesse E, Screpanti I, et al. Proapoptotic function of the retinoblastoma tumor suppressor protein. Cancer Cell. 2009;15:184-94 pubmed publisher
    ..Together, these data reveal a direct role for pRB in the induction of apoptosis in response to genotoxic or oncogenic stress. ..
  68. Gong C, Liu H, Song R, Zhong T, Lou M, Wang T, et al. ATR-CHK1-E2F3 signaling transactivates human ribonucleotide reductase small subunit M2 for DNA repair induced by the chemical carcinogen MNNG. Biochim Biophys Acta. 2016;1859:612-26 pubmed publisher
    ..The upregulated RRM2 translocated to the nucleus for DNA repair. Further study showed that E2F3 transactivated RRM2 expression by directly binding to its promoter after MNNG exposure...
  69. Al Ahmed H, Nada O. E2F3 transcription factor: A promising biomarker in lung cancer. Cancer Biomark. 2017;19:21-26 pubmed publisher
    ..In the present study we measured the blood E2F3 mRNA using real-time RT-PCR technique in order to evaluate its clinical significance in early diagnosis and ..
  70. Gamper I, Burkhart D, Bywater M, Garcia D, Wilson C, Kreuzaler P, et al. Determination of the physiological and pathological roles of E2F3 in adult tissues. Sci Rep. 2017;7:9932 pubmed publisher
    ..Applying this switchable technology to the key cell cycle transcription factor E2F3, we demonstrate that elevated levels of E2F3 drive ectopic proliferation in multiple tissues...
  71. Major J, Salih M, Tuana B. E2F6 protein levels modulate drug induced apoptosis in cardiomyocytes. Cell Signal. 2017;40:230-238 pubmed publisher
    ..This correlated with a decrease in the pro-apoptotic E2F3 protein levels...
  72. Lees J, Saito M, Vidal M, Valentine M, Look T, Harlow E, et al. The retinoblastoma protein binds to a family of E2F transcription factors. Mol Cell Biol. 1993;13:7813-25 pubmed
    ..These observations suggest that the E2F activities described previously result from the combined action of a family of proteins. ..
  73. Sampieri K, Mencarelli M, Epistolato M, Toti P, Lazzi S, Bruttini M, et al. Genomic differences between retinoma and retinoblastoma. Acta Oncol. 2008;47:1483-92 pubmed publisher
    ..1, MYCN at 2p24.1, E2F3 at 6p22 and CDH11 at 16q22) in retina, retinoma and retinoblastoma tissues from two different patients...
  74. De Keuckelaere E, Hulpiau P, Saeys Y, Berx G, van Roy F. Nanos genes and their role in development and beyond. Cell Mol Life Sci. 2018;75:1929-1946 pubmed publisher
    ..Repression of the E2F3 oncogene product is, indeed, mediated by cooperation between the Nanos/Pumilio complex and miRNAs...
  75. Asp P, Acosta Alvear D, Tsikitis M, van Oevelen C, Dynlacht B. E2f3b plays an essential role in myogenic differentiation through isoform-specific gene regulation. Genes Dev. 2009;23:37-53 pubmed publisher
    ..The E2f3 locus encodes E2f3a and E2f3b proteins, and available data suggest that they regulate cell cycle-dependent gene ..
  76. Miles W, Tschop K, Herr A, Ji J, Dyson N. Pumilio facilitates miRNA regulation of the E2F3 oncogene. Genes Dev. 2012;26:356-68 pubmed publisher
    ..The human Pumilio homologs Pum 1 and Pum 2 repress the translation of E2F3 by binding to the E2F3 3' untranslated region (UTR) and also enhance the activity of multiple E2F3 targeting ..
  77. Vimala K, Sundarraj S, Sujitha M, Kannan S. Curtailing overexpression of E2F3 in breast cancer using siRNA (E2F3)-based gene silencing. Arch Med Res. 2012;43:415-22 pubmed publisher
    The E2F3 transcription factor claims its role in controlling cell cycle progression. As reported earlier, nuclear E2F3 overexpression leads to development of bladder and prostate cancer in humans...
  78. Hussain M, Javeed A, Ashraf M, Siddique S, Riaz A, Mukhtar M. Exploration of potential ligands against cancer-causing transcription factor E2F3. Pak J Pharm Sci. 2012;25:793-801 pubmed
    ..In this paper, a homology model of DNA-binding domain of transcription factor E2F3 was generated according to X-ray structure of E2F4...
  79. Pierce A, Schneider Broussard R, Philhower J, Johnson D. Differential activities of E2F family members: unique functions in regulating transcription. Mol Carcinog. 1998;22:190-8 pubmed
    ..We found that, consistent with a role for E2F5 in transcriptional repression, E2F5's binding partner p130, like Rb, could also actively repress transcription when directly bound to a target promoter. ..
  80. Mååg J, Fisher O, Levert Mignon A, Kaczorowski D, Thomas M, Hussey D, et al. Novel Aberrations Uncovered in Barrett's Esophagus and Esophageal Adenocarcinoma Using Whole Transcriptome Sequencing. Mol Cancer Res. 2017;15:1558-1569 pubmed publisher
    ..A novel 4-gene signature (CTSL, COL17A1, KLF4, and E2F3) was identified, externally validated, and shown to provide excellent distinction of EAC from BE...
  81. Yang J, Zhang H, Qin C. MicroRNA-217 functions as a prognosis predictor and inhibits pancreatic cancer cell proliferation and invasion via targeting E2F3. Eur Rev Med Pharmacol Sci. 2017;21:4050-4057 pubmed
    ..Cell apoptosis was checked via Annexin V-FITC/PI apoptosis kit. The protein expression of E2F3 was detected by Western blot...
  82. Ginsberg D. E2F3-a novel repressor of the ARF/p53 pathway. Dev Cell. 2004;6:742-3 pubmed
    ..In a recent paper, Lees and coworkers investigate the regulation of Arf expression by E2Fs and demonstrate that in normal cells E2F3 is a pivotal repressor of Arf.
  83. Nagel S, Scherr M, Quentmeier H, Kaufmann M, Zaborski M, Drexler H, et al. HLXB9 activates IL6 in Hodgkin lymphoma cell lines and is regulated by PI3K signalling involving E2F3. Leukemia. 2005;19:841-6 pubmed
    ..Downstream analysis of PI3K revealed that E2F3 may mediate activation of HLXB9...
  84. Kim S, Kim A, Jeong J, Choi J, Kweon H. 4-hexylresorcinol stimulates the differentiation of SCC-9 cells through the suppression of E2F2, E2F3 and Sp3 expression and the promotion of Sp1 expression. Oncol Rep. 2012;28:677-81 pubmed publisher
    ..genes, the protein expression of several cell proliferation related factors, including E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, Sp1 and Sp3, were determined by western blot analyses...
  85. Lu Y, Li W. Functional characterization of E2F3b in human HepG2 liver cancer cell line. J Cell Biochem. 2017;: pubmed publisher
    b>E2F3 is a transcription factor that has been shown to be overexpressed in hepatocellular carcinoma (HCC). It is well-known that the E2F3 gene encodes two proteins E2F3a and E2F3b...
  86. Oeggerli M, Schraml P, Ruiz C, Bloch M, Novotny H, Mirlacher M, et al. E2F3 is the main target gene of the 6p22 amplicon with high specificity for human bladder cancer. Oncogene. 2006;25:6538-43 pubmed
    ..Candidate target genes for the 6p22 amplicon include E2F3 and the adjacent gene NM_017774...
  87. von Eyss B, Maaskola J, Memczak S, Möllmann K, Schuetz A, Loddenkemper C, et al. The SNF2-like helicase HELLS mediates E2F3-dependent transcription and cellular transformation. EMBO J. 2012;31:972-85 pubmed publisher
    ..b>E2F3 is uniquely amplified in specific human tumours where its expression is inversely correlated with the survival of ..
  88. Huang L, Luo J, Cai Q, Pan Q, Zeng H, Guo Z, et al. MicroRNA-125b suppresses the development of bladder cancer by targeting E2F3. Int J Cancer. 2011;128:1758-69 pubmed publisher
    ..b>E2F3, which was critical for G1/S transition and was overexpressed in most of poor-differentiated bladder cancers, was ..
  89. Karwaciak I, Pulaski L, Ratajewski M. Regulation of the human ABCB10 gene by E2F transcription factors. Genomics. 2014;104:520-9 pubmed publisher
    ..We cloned a functional promoter sequence, and then showed that E2F2, E2F3 and E2F4 can activate transcription from the ABCB10 promoter...
  90. Yang H, Zheng W, Shuai X, Chang R, Yu L, Fang F, et al. MicroRNA-424 inhibits Akt3/E2F3 axis and tumor growth in hepatocellular carcinoma. Oncotarget. 2015;6:27736-50 pubmed publisher
    ..Multi-pathway reporter arrays suggested that miR-424 suppressed the pRb-E2F pathway. Consistently, Akt3 and E2F3 were identified as the targets of miR-424 as evidenced by that ectopic miR-424 expression suppressed Akt3 and E2F3 ..
  91. Yamochi T, Semba K, Tsuji K, Mizumoto K, Sato H, Matsuura Y, et al. ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3). Eur J Biochem. 2001;268:6076-82 pubmed
    ..We therefore conclude that p70ik3-1 is a substrate for cdk3-mediated phosphorylation. ..
  92. He Y, Cress W. E2F-3B is a physiological target of cyclin A. J Biol Chem. 2002;277:23493-9 pubmed
    ..Finally, in synchronized cells, we observe down-regulation of E2F-3B protein expression coincident with the up-regulation of cyclin A. We conclude that E2F-3B is a physiological target of cyclin A. ..