E2F2

Summary

Gene Symbol: E2F2
Description: E2F transcription factor 2
Alias: E2F-2, transcription factor E2F2
Species: human
Products:     E2F2

Top Publications

  1. Okamoto O, Oba Shinjo S, Lopes L, Nagahashi Marie S. Expression of HOXC9 and E2F2 are up-regulated in CD133(+) cells isolated from human astrocytomas and associate with transformation of human astrocytes. Biochim Biophys Acta. 2007;1769:437-42 pubmed
    ..Up-regulation of two of such genes, E2F2 and HOXC9, was detected in a set of 54 astrocytomas of different grades and significantly associated with ..
  2. Workman A, Jones C. Analysis of the cell cycle regulatory protein (E2F1) after infection of cultured cells with bovine herpesvirus 1 (BHV-1) or herpes simplex virus type 1 (HSV-1). Virus Res. 2011;160:66-73 pubmed publisher
    ..infection increases E2F1 protein levels, the bICP0 early promoter is activated more than 100 fold by E2F1 or E2F2, and silencing E2F1 reduced the efficiency of productive infection...
  3. Yu L, Ke J, Du X, Yu Z, Gao D. Genetic characterization of thymoma. Sci Rep. 2019;9:2369 pubmed publisher
    ..This microarray results were further confirmed through real-time PCR. 8 most dysregulated genes were verified: E2F2, EPHA1, CCL25 and MCM2 were upregulated; and IL6, FABP4, CD36 and MYOC were downregulated...
  4. Sun C, Li S, Hu W, Zhang J, Zhou Q, Liu C, et al. Comprehensive Analysis of the Expression and Prognosis for E2Fs in Human Breast Cancer. Mol Ther. 2019;: pubmed publisher
    ..The expression levels of E2F2, 5, 7, and 8 were correlated with advanced tumor stage...
  5. Chen X, Paranjape T, Stahlhut C, McVeigh T, Keane F, Nallur S, et al. Targeted resequencing of the microRNAome and 3'UTRome reveals functional germline DNA variants with altered prevalence in epithelial ovarian cancer. Oncogene. 2015;34:2125-37 pubmed publisher
    ..Multiple single-nucleotide polymorphisms in the 3'UTR of the vascular endothelial growth factor receptor/FLT1, E2F2 and PCM1 oncogenes were highly enriched in ovarian cancer patients compared with the 1000 Genome Project...
  6. Hu Y, Jin G, Li B, Chen Y, Zhong L, Chen G, et al. Suppression of miRNA let-7i-5p promotes cardiomyocyte proliferation and repairs heart function post injury by targetting CCND2 and E2F2. Clin Sci (Lond). 2019;133:425-441 pubmed publisher
    ..b>E2F2 and CCND2 were identified as the targets of let-7i-5p, mediating its effect in regulating the cell cycle of CMs...
  7. Folk W, Kumari A, Iwasaki T, Pyndiah S, Johnson J, Cassimere E, et al. Loss of the tumor suppressor BIN1 enables ATM Ser/Thr kinase activation by the nuclear protein E2F1 and renders cancer cells resistant to cisplatin. J Biol Chem. 2019;294:5700-5719 pubmed publisher
    ..However, E2F2 or E2F3 depletion did not recapitulate the cisplatin sensitivity elicited by E2F1 elimination...
  8. Liu J, Jian T, Yue C, Chen D, Chen W, Bao T, et al. Chemo-resistant Gastric Cancer Associated Gene Expression Signature: Bioinformatics Analysis Based on Gene Expression Omnibus. Anticancer Res. 2019;39:1689-1698 pubmed publisher
    ..Five DEGs, including ANTXR1, EFNA5, GAMT, E2F2 and NRCAM, were associated with relapse-free survival and overall survival...
  9. Li H, Zhao X, Li C, Sheng C, Bai Z. Integrated analysis of lncRNA-associated ceRNA network reveals potential biomarkers for the prognosis of hepatitis B virus-related hepatocellular carcinoma. Cancer Manag Res. 2019;11:877-897 pubmed publisher
    ..b>E2F2, CDK1, and CCNE1 were significantly enriched into cell cycle pathway...

More Information

Publications147 found, 100 shown here

  1. Aubrecht T, Faden A, Sabirzhanov B, Glaser E, Roelofs B, Polster B, et al. Comparing effects of CDK inhibition and E2F1/2 ablation on neuronal cell death pathways in vitro and after traumatic brain injury. Cell Death Dis. 2018;9:1121 pubmed publisher
    ..effects by CDK inhibitors after TBI, examination of neuronal apoptotic mechanisms in E2F1-/-/E2F2-/- or E2F2-/- transgenic mice following CCI suggests that E2F1 and/or E2F2 likely play only a ..
  2. Wang S, Wang L, Wu C, Sun S, Pan J. E2F2 directly regulates the STAT1 and PI3K/AKT/NF-κB pathways to exacerbate the inflammatory phenotype in rheumatoid arthritis synovial fibroblasts and mouse embryonic fibroblasts. Arthritis Res Ther. 2018;20:225 pubmed publisher
    Expression of E2F transcription factor 2 (E2F2), a transcription factor related to the cell cycle, is abnormally high in rheumatoid arthritis synovial fibroblasts (RASFs)...
  3. Fukuyo Y, Mogi K, Tsunematsu Y, Nakajima T. E2FBP1/hDril1 modulates cell growth through downregulation of promyelocytic leukemia bodies. Cell Death Differ. 2004;11:747-59 pubmed
    ..Thus, the function of E2FBP1/hDril1 is required for maintenance of survival potential of the cells. Our data suggest a novel mechanism to govern cellular integrity through the modulation of nuclear depots...
  4. Gnani D, Romito I, Artuso S, Chierici M, De Stefanis C, Panera N, et al. Focal adhesion kinase depletion reduces human hepatocellular carcinoma growth by repressing enhancer of zeste homolog 2. Cell Death Differ. 2017;24:889-902 pubmed publisher
    ..experiments demonstrated that FAK affected EZH2 expression and function by modulating, at least in part, p53 and E2F2/3 transcriptional activity...
  5. Harmanci A, Youngblood M, Clark V, Coskun S, Henegariu O, Duran D, et al. Integrated genomic analyses of de novo pathways underlying atypical meningiomas. Nat Commun. 2017;8:14433 pubmed publisher
    ..atypical meningiomas exhibit upregulation of EZH2, the catalytic subunit of the PRC2 complex, as well as the E2F2 and FOXM1 transcriptional networks...
  6. Li X, Zhang Z, Jiang H, Li Q, Wang R, Pan H, et al. Circular RNA circPVT1 Promotes Proliferation and Invasion Through Sponging miR-125b and Activating E2F2 Signaling in Non-Small Cell Lung Cancer. Cell Physiol Biochem. 2018;51:2324-2340 pubmed publisher
    ..Western blot and immunohistochemistry assays were performed to detect the protein levels involved in E2F2 pathway. We found that circPVT1 was upregulated in NSCLC specimens and cells...
  7. Wu J, Sabirzhanov B, Stoica B, Lipinski M, Zhao Z, Zhao S, et al. Ablation of the transcription factors E2F1-2 limits neuroinflammation and associated neurological deficits after contusive spinal cord injury. Cell Cycle. 2015;14:3698-712 pubmed publisher
    ..E2F1 and E2F2 are members of the activator sub-family of E2F transcription factors that play an important role in proliferating ..
  8. Sheikh B, Phipson B, El Saafin F, Vanyai H, Downer N, Bird M, et al. MOZ (MYST3, KAT6A) inhibits senescence via the INK4A-ARF pathway. Oncogene. 2015;34:5807-20 pubmed publisher
    ..3 lysine 9 (H3K9) and H3K27 acetylation at the transcriptional start sites of at least four genes, Cdc6, Ezh2, E2f2 and Melk, and normal mRNA levels of these genes. CDC6, EZH2 and E2F2 are known inhibitors of the INK4A-ARF pathway...
  9. Chen L, Yu J, Lu Z, Zhang W. E2F2 induction in related to cell proliferation and poor prognosis in non-small cell lung carcinoma. Int J Clin Exp Pathol. 2015;8:10545-54 pubmed
    ..In the present study, we examined whether E2F2 is related to the poor prognosis of NSCLC and its role in progress of NSCLC...
  10. Manicum T, Ni F, Ye Y, Fan X, Chen B. Prognostic values of E2F mRNA expression in human gastric cancer. Biosci Rep. 2018;38: pubmed publisher
    ..factors are divided into two subfamilies: transcription activators (E2F transcription factors 1 (E2F1), 2 (E2F2) and 3a (E2F3a)) and repressors (E2F3b, E2F transcription factors 4 (E2F4), 5 (E2F5), 6 (E2F6), 7 (E2F7) and 8 (..
  11. Xie L, Li T, Yang L. E2F2 induces MCM4, CCNE2 and WHSC1 upregulation in ovarian cancer and predicts poor overall survival. Eur Rev Med Pharmacol Sci. 2017;21:2150-2156 pubmed
    To explore the genes co-upregulated with E2F2 in ovarian cancer and their association with survival outcomes in ovarian cancer patients. The raw data of GDS3592 was downloaded from GEO datasets for reanalysis...
  12. Lim S, Park S, Lee J, Kim S, Kim J, Min J, et al. Differential expression of microRNAs in recombinant Chinese hamster ovary cells treated with sodium butyrate using digital RNA counting. J Biotechnol. 2018;283:37-42 pubmed publisher
    ..the potential corresponding target mRNAs for the selected mature miRNAs, seven cell growth-related target genes (e2f2, akt2, mtor, bcl-2, bim, p38α, and bmf) and five N-glycosylation-related target genes (neu1, b4galt3, gale, man1b1 ..
  13. Bao X, Hu X. Up-regulated expression of E2F2 is necessary for p16INK4a-induced cartilage injury. BMC Musculoskelet Disord. 2018;19:334 pubmed publisher
    ..The increased expressions of p16INK4a and E2F2 were accompanied with cartilage degradation induced by IL-1β...
  14. Castillo D, Campalans A, Belluscio L, Carcagno A, Radicella J, Cánepa E, et al. E2F1 and E2F2 induction in response to DNA damage preserves genomic stability in neuronal cells. Cell Cycle. 2015;14:1300-14 pubmed publisher
    ..We show a novel mechanism, conserved among diverse species, in which E2F1 and E2F2, the latter specifically in neuronal cells, are transcriptionally induced after DNA damage...
  15. Kresoja Rakic J, Kapaklikaya E, Ziltener G, Dalcher D, Santoro R, Christensen B, et al. Identification of cis- and trans-acting elements regulating calretinin expression in mesothelioma cells. Oncotarget. 2016;7:21272-86 pubmed publisher
    ..EMSA and ChIP assays confirmed binding of NRF-1 and E2F2 to the CALB2 promoter and siRNA knockdown of NRF-1 led to decreased expression of calretinin...
  16. Lee M, Oprea Ilies G, Saavedra H. Silencing of E2F3 suppresses tumor growth of Her2+ breast cancer cells by restricting mitosis. Oncotarget. 2015;6:37316-34 pubmed publisher
    The E2F transcriptional activators E2F1, E2F2 and E2F3a regulate many important cellular processes, including DNA replication, apoptosis and centrosome duplication...
  17. Li L, Shi B, Chen J, Li C, Wang S, Wang Z, et al. An E2F1/MiR-17-92 Negative Feedback Loop mediates proliferation of Mouse Palatal Mesenchymal Cells. Sci Rep. 2017;7:5148 pubmed publisher
    ..E2F1 and E2F3, but not E2F2, were extensively expressed in mouse palate...
  18. Iglesias Ara A, Zenarruzabeitia O, Buelta L, Merino J, Zubiaga A. E2F1 and E2F2 prevent replicative stress and subsequent p53-dependent organ involution. Cell Death Differ. 2015;22:1577-89 pubmed publisher
    Tissue homeostasis requires tight regulation of cellular proliferation, differentiation and apoptosis. E2F1 and E2F2 transcription factors share a critical role in tissue homeostasis, since their combined inactivation results in overall ..
  19. Zhou S, Sun H, Zheng B, Li R, Zhang W. Cell cycle transcription factor E2F2 mediates non-stress temperature response of AtHSP70-4 in Arabidopsis. Biochem Biophys Res Commun. 2014;455:139-46 pubmed publisher
    ..EMSA assay verified one number of Arabidopsis E2F family-E2F2 could bind to AtHSP70-4 promoter via this motif...
  20. Raj D, Liu T, Samadashwily G, Li F, Grossman D. Survivin repression by p53, Rb and E2F2 in normal human melanocytes. Carcinogenesis. 2008;29:194-201 pubmed
    ..We demonstrate a novel role for E2F2 in the negative regulation of survivin expression...
  21. Bai H, Harmancı A, Erson Omay E, Li J, Coşkun S, Simon M, et al. Integrated genomic characterization of IDH1-mutant glioma malignant progression. Nat Genet. 2016;48:59-66 pubmed publisher
    ..These include activation of the MYC and RTK-RAS-PI3K pathways and upregulation of the FOXM1- and E2F2-mediated cell cycle transitions, as well as epigenetic silencing of developmental transcription factor genes bound ..
  22. Karlseder J, Rotheneder H, Wintersberger E. Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F. Mol Cell Biol. 1996;16:1659-67 pubmed
    ..For this interaction, the C-terminal part of Sp1 and the N terminus of E2F1, a domain also present in E2F2 and E2F3 but absent in E2F4 and E2F5, were essential...
  23. Wang H, Zhang X, Liu Y, Ni Z, Lin Y, Duan Z, et al. Downregulated miR-31 level associates with poor prognosis of gastric cancer and its restoration suppresses tumor cell malignant phenotypes by inhibiting E2F2. Oncotarget. 2016;7:36577-36589 pubmed publisher
    ..Luciferase reporter assays and western blot revealed that E2F2 is the direct target of miR-31...
  24. Thompson P, Tipney H, Brass A, Noyes H, Kemp S, Naessens J, et al. Claudin 13, a member of the claudin family regulated in mouse stress induced erythropoiesis. PLoS ONE. 2010;5: pubmed publisher
    ..Genes clustering with Cldn13 on microarrays are key regulators of erythropoiesis (Tal1, Trim10, E2f2), erythrocyte membrane proteins (Rhd and Gypa), associated with red cell volume (Tmcc2) and indirectly associated ..
  25. Boi M, Todaro M, Vurchio V, Yang S, MOON J, Kwee I, et al. Therapeutic efficacy of the bromodomain inhibitor OTX015/MK-8628 in ALK-positive anaplastic large cell lymphoma: an alternative modality to overcome resistant phenotypes. Oncotarget. 2016;7:79637-79653 pubmed publisher
    ..OTX015-modulated genes included transcription factors (E2F2, NFKBIZ, FOS, JUNB, ID1, HOXA5 and HOXC6), members of multiple signaling pathways (ITK, PRKCH, and MKNK2), and ..
  26. Giangrande P, Hallstrom T, Tunyaplin C, Calame K, Nevins J. Identification of E-box factor TFE3 as a functional partner for the E2F3 transcription factor. Mol Cell Biol. 2003;23:3707-20 pubmed
    ..In contrast, neither E2F1 nor E2F2 interacted with the p68 promoter under these conditions...
  27. Mason D, Zhang X, Marques T, Rose B, Khoury S, Hill M, et al. Human papillomavirus 16 E6 modulates the expression of miR-496 in oropharyngeal cancer. Virology. 2018;521:149-157 pubmed publisher
    ..high risk E6 oncoprotein down-regulated miR-496, impacting upon the post-transcriptional control of the transcription factor E2F2. These HPV specific miRNAs were integrated with the HPV16 interactome to identify possible mechanistic ..
  28. Suzuki D, Nakahata A, Okamoto O. Knockdown of E2F2 inhibits tumorigenicity, but preserves stemness of human embryonic stem cells. Stem Cells Dev. 2014;23:1266-74 pubmed publisher
    ..A previous study has identified hyperexpressed genes in cancer stem cells, among which is E2F2, a gene involved in malignant transformation and stem cell self-renewal...
  29. Maldonado E, Delgado I, Furland N, Buqué X, Iglesias A, Aveldaño M, et al. The E2F2 transcription factor sustains hepatic glycerophospholipid homeostasis in mice. PLoS ONE. 2014;9:e112620 pubmed publisher
    ..E2Fs are master regulators of cellular proliferation. We have recently shown that E2F2 activity facilitates the completion of liver regeneration after partial hepatectomy (PH) by regulating the ..
  30. Gujar A, Le S, Mao D, Dadey D, Turski A, Sasaki Y, et al. An NAD+-dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma. Proc Natl Acad Sci U S A. 2016;113:E8247-E8256 pubmed publisher
    ..Regulatory network analysis of RNA sequencing data using GSCs treated with NAMPT inhibitor identified transcription factor E2F2 as the center of a transcriptional hub in the NAD+-dependent network...
  31. Xie B, Wang P, Zhao C, Qiu L. Genomic structure, expression pattern, and functional characterization of transcription factor E2F-2 from black tiger shrimp (Penaeus monodon). PLoS ONE. 2017;12:e0177420 pubmed publisher
    ..After dsRNA-E2F-2 injection, gonadosomatic index of shrimp was significantly lower than those following dsRNA-GFP and phosphate-buffered solution injections. Therefore, PmE2F-2 may be involved in ovarian maturation in P. monodon. ..
  32. Zhu H, Mi W, Luo H, Chen T, Liu S, Raman I, et al. Whole-genome transcription and DNA methylation analysis of peripheral blood mononuclear cells identified aberrant gene regulation pathways in systemic lupus erythematosus. Arthritis Res Ther. 2016;18:162 pubmed publisher
    ..Hypomethylated CpG sites were detected on these genes. The gene expressions for MX1, GPR84, and E2F2 were increased in SLE LN(+) as compared to SLE LN(-) patients...
  33. Chaussepied M, Ginsberg D. Transcriptional regulation of AKT activation by E2F. Mol Cell. 2004;16:831-7 pubmed
    ..AKT activation was shown to inhibit E2F1induced apoptosis. Therefore, our results suggest the existence of a negative feedback loop involving E2F and AKT. ..
  34. Blanchard D, Georlette D, Antoszewski L, Botchan M. Chromatin reader L(3)mbt requires the Myb-MuvB/DREAM transcriptional regulatory complex for chromosomal recruitment. Proc Natl Acad Sci U S A. 2014;111:E4234-43 pubmed publisher
    ..Mip120 (Lin54) is required for L(3)mbt recruitment to chromosomes, whereas Mip130 (Lin9) (an MMB core protein) and E2f2 (an MMB transcriptional repressor) are not, but are essential for repression...
  35. Liu M, Zhou K, Huang Y, Cao Y. The candidate oncogene (MCRS1) promotes the growth of human lung cancer cells via the miR-155-Rb1 pathway. J Exp Clin Cancer Res. 2015;34:121 pubmed publisher
    ..expressions of various genes related to cell proliferation, including Rb1, TP53, cell cycle-related genes, MYC, E2F2, PCNA, and Ki67. However, MCRS1 did not directly bind to these differentially expressed genes...
  36. Di Fiore R, Drago Ferrante R, Pentimalli F, Di Marzo D, Forte I, D Anneo A, et al. MicroRNA-29b-1 impairs in vitro cell proliferation, self‑renewal and chemoresistance of human osteosarcoma 3AB-OS cancer stem cells. Int J Oncol. 2014;45:2013-23 pubmed publisher
    ..Among these targets we analyzed CD133, N-Myc, CCND2, E2F1 and E2F2, Bcl-2 and IAP-2. We also analyzed the most important stemness markers as Oct3/4, Sox2 and Nanog...
  37. Zhu X, Wu L, Yao J, Jiang H, Wang Q, Yang Z, et al. MicroRNA let-7c Inhibits Cell Proliferation and Induces Cell Cycle Arrest by Targeting CDC25A in Human Hepatocellular Carcinoma. PLoS ONE. 2015;10:e0124266 pubmed publisher
    ..to identify the targets of let-7c and to determine the effects of let-7c on CDC25A, CyclinD1, CDK6, pRb and E2F2 expression. The results showed that the expression levels of let-7c were significantly decreased in HCC cell lines...
  38. Roussel Gervais A, Couture C, Langlais D, Takayasu S, Balsalobre A, Rueda B, et al. The Cables1 Gene in Glucocorticoid Regulation of Pituitary Corticotrope Growth and Cushing Disease. J Clin Endocrinol Metab. 2016;101:513-22 pubmed publisher
    ..Two Myc genes (L-Myc and N-Myc) and E2F2 are repressed by GCs, whereas genes for the negative regulators of the cell cycle, Gadd45β, Gadd45γ, and ..
  39. Mazzio E, Soliman K. HTP Nutraceutical Screening for Histone Deacetylase Inhibitors and Effects of HDACis on Tumor-suppressing miRNAs by Trichostatin A and Grapeseed (Vitis vinifera) in HeLa cells. Cancer Genomics Proteomics. 2017;14:17-33 pubmed
    ..similar miRNAs predicted to destroy the following influential oncogenes: NFkB, NRAS, KRAS, HRAS, MYC, TGFBR1, E2F1, E2F2, BCL21, CDKN1A, CDK6, HIF1a, and VEGFA...
  40. Wong M, Tee A, Milazzo G, Bell J, Poulos R, Atmadibrata B, et al. The Histone Methyltransferase DOT1L Promotes Neuroblastoma by Regulating Gene Transcription. Cancer Res. 2017;77:2522-2533 pubmed publisher
    ..shRNA-mediated depletion of DOT1L reduced mRNA and protein expression of N-Myc target genes ODC1 and E2F2 DOT1L bound to the Myc Box II domain of N-Myc protein, and knockdown of DOT1L reduced histone H3K79 methylation ..
  41. Kadri Z, Lefevre C, Goupille O, Penglong T, Granger Locatelli M, Fucharoen S, et al. Erythropoietin and IGF-1 signaling synchronize cell proliferation and maturation during erythropoiesis. Genes Dev. 2015;29:2603-16 pubmed publisher
    ..This study sheds light on the GATA-1 pathways that synchronize cell proliferation and differentiation for tissue homeostasis. ..
  42. Ankers J, Awais R, Jones N, Boyd J, Ryan S, Adamson A, et al. Dynamic NF-κB and E2F interactions control the priority and timing of inflammatory signalling and cell proliferation. elife. 2016;5: pubmed publisher
    ..These data identify new mechanisms by which the cellular response to stress is differentially controlled at different stages of the cell cycle. ..
  43. Benevolenskaya E, Murray H, Branton P, Young R, Kaelin W. Binding of pRB to the PHD protein RBP2 promotes cellular differentiation. Mol Cell. 2005;18:623-35 pubmed
    ..Our results suggest that promotion of differentiation by pRB involves neutralization of free RBP2 and transcriptional activation of RBP2 targets linked to euchromatin maintenance. ..
  44. Di Fiore R, Drago Ferrante R, Pentimalli F, Di Marzo D, Forte I, Carlisi D, et al. Let-7d miRNA Shows Both Antioncogenic and Oncogenic Functions in Osteosarcoma-Derived 3AB-OS Cancer Stem Cells. J Cell Physiol. 2016;231:1832-41 pubmed publisher
    ..We found that let-7d-overexpression reduced cell proliferation by decreasing CCND2 and E2F2 cell-cycle-activators and increasing p21 and p27 CDK-inhibitors...
  45. Farra R, Dapas B, Baiz D, Tonon F, Chiaretti S, Del Sal G, et al. Impairment of the Pin1/E2F1 axis in the anti-proliferative effect of bortezomib in hepatocellular carcinoma cells. Biochimie. 2015;112:85-95 pubmed publisher
    ..Moreover, Pin1-E2F1 promote HuH7 growth via the up-regulation of cyclin D1, cyclin E, cyclin A2, E2F2 and in part E2F3...
  46. Bigagli E, De Filippo C, Castagnini C, Toti S, Acquadro F, Giudici F, et al. DNA copy number alterations, gene expression changes and disease-free survival in patients with colorectal cancer: a 10 year follow-up. Cell Oncol (Dordr). 2016;39:545-558 pubmed
    ..HMGB1 and ERBB3 genes were associated with copy number gains, whereas decreased expression levels of the MUC1, E2F2, HRAS and SIRT3 genes were associated with copy number losses...
  47. Loo S, Ab Hamid S, Musa M, Wong K. DNMT1 is associated with cell cycle and DNA replication gene sets in diffuse large B-cell lymphoma. Pathol Res Pract. 2018;214:134-143 pubmed publisher
    ..05). Expression of genes involved in the activation of cell cycle and DNA replication (e.g. CDK1, CCNA2, E2F2, PCNA, RFC5 and POLD3) were highly correlated (r>0...
  48. Liu X, Tseng S, Zhang M, Chen S, Tighe S, Lu W, et al. LIF-JAK1-STAT3 signaling delays contact inhibition of human corneal endothelial cells. Cell Cycle. 2015;14:1197-206 pubmed publisher
    ..The LIF-JAK1-STAT3 signaling is coupled with upregulation of E2F2 colocalized with nuclear p-Rb and with concomitant downregulation of p16(INK4a), of which upregulation is linked to ..
  49. Zhao S, Niu F, Xu C, Ye L, Bi G, Chen L, et al. Microarray and ChIP-seq data analysis revealed changes in p53-mediated transcriptional regulation in Nutlin-3-treated U2OS cells. Mol Med Rep. 2015;12:4284-4290 pubmed publisher
    ..A total of 39 DEGs were directly regulated by p53 and two were the transcription factors (TFs), E2F2 and HOXA1. E2F2 regulated 25 DEGs, while HOXA1 regulated one DEG...
  50. Swartz K, Wood S, Murthy T, Ramirez O, Qin G, Pillai M, et al. E2F-2 Promotes Nuclear Condensation and Enucleation of Terminally Differentiated Erythroblasts. Mol Cell Biol. 2017;37: pubmed publisher
    ..Together, our data reveal novel, lineage-specific functions for E2F-2 and suggest that some mitotic kinases have specialized roles supporting enucleation of maturing erythroblasts. ..
  51. Yuwanita I, Barnes D, Monterey M, O Reilly S, Andrechek E. Increased metastasis with loss of E2F2 in Myc-driven tumors. Oncotarget. 2015;6:38210-24 pubmed publisher
    ..Surprisingly, we observed that the loss of E2F2 sharply increased the percentage of lung metastasis in MMTV-Myc transgenic mice...
  52. Kim J, Lee B, Choi E, Lee K, Choi S, Cho J, et al. Reverse Expression of Aging-Associated Molecules through Transfection of miRNAs to Aged Mice. Mol Ther Nucleic Acids. 2017;6:106-115 pubmed publisher
    ..The expression of the genes associated in the network of these miRNAs, Bcl2, Ppara, E2f1, E2f2, Akt, Ccnd1, and Smad2/3, also was altered in the liver of aged mice...
  53. Wei D, Li A, Zhao C, Wang H, Mei C, Khan R, et al. Transcriptional Regulation by CpG Sites Methylation in the Core Promoter Region of the Bovine SIX1 Gene: Roles of Histone H4 and E2F2. Int J Mol Sci. 2018;19: pubmed publisher
    ..ChIP) assay, in combination with site-directed mutation and siRNA interference, demonstrated that histone H4 and E2F2 bind to the -216/-28 region and play important roles in SIX1 methylation regulation during development...
  54. Zhang R, Liu Z, Li Y, Wu B. LXR agonist regulates the proliferation and apoptosis of human T-Cell acute lymphoblastic leukemia cells via the SOCS3 pathway. Int J Biochem Cell Biol. 2016;78:180-185 pubmed publisher
    ..Cells were transfected with small-interfering RNA (si-RNA) against SOCS3 and E2F family members (including E2F1, E2F2 and E2F3a) followed by treatment with LXR activator GW3965...
  55. Arai T, Fuse M, Goto Y, Kaga K, Kurozumi A, Yamada Y, et al. Molecular pathogenesis of interstitial cystitis based on microRNA expression signature: miR-320 family-regulated molecular pathways and targets. J Hum Genet. 2018;63:543-554 pubmed publisher
    ..Novel approaches that identify aberrantly expressed miRNA regulatory networks in IC could provide new prognostic markers and therapeutic targets for this disease. ..
  56. Lawrenson K, Iversen E, Tyrer J, Weber R, Concannon P, Hazelett D, et al. Common variants at the CHEK2 gene locus and risk of epithelial ovarian cancer. Carcinogenesis. 2015;36:1341-53 pubmed publisher
    ..We found evidence of associations with EOC risk for variants at FANCA, EXO1, E2F4, E2F2, CREB5 and CHEK2 genes (P ≤ 0.001)...
  57. Liban T, Thwaites M, Dick F, Rubin S. Structural Conservation and E2F Binding Specificity within the Retinoblastoma Pocket Protein Family. J Mol Biol. 2016;428:3960-3971 pubmed publisher
    ..of these residues in p107 to match the analogous residue in Rb results in an increase in affinity for E2F1 and E2F2 and an increase in the ability of p107 to inhibit E2F2 transactivation...
  58. Li Y, Sturgis E, Yuan Y, Lu M, Cao X, Wei Q, et al. Effect of human papillomavirus seropositivity and E2F2 promoter variants on risk of squamous cell carcinomas of oropharynx and oral cavity. Carcinogenesis. 2016;: pubmed
    Given roles of HPV and genetic factors in cancer risk, we evaluated associations of HPV16 seropositivity and five E2F2 promoter variants with squamous cell carcinoma of oropharynx (SCCOP) and squamous cell carcinoma of oral cavity (SCCOC) ..
  59. Liu S, Zhang Y, Gao Y, Zhang L, Chen H, Zhou Q, et al. MiR-378 Plays an Important Role in the Differentiation of Bovine Preadipocytes. Cell Physiol Biochem. 2015;36:1552-62 pubmed
    ..E2F transcription factor 2 (E2F2) and Ras-related nuclear (RAN)-binding protein 10 (RANBP10) were the two target genes of miR-378...
  60. Zappia M, Frolov M. E2F function in muscle growth is necessary and sufficient for viability in Drosophila. Nat Commun. 2016;7:10509 pubmed publisher
    ..Interestingly, E2f1 provides a major contribution to the regulation of myogenic function, while E2f2 appears to be less important...
  61. Lal A, Navarro F, Maher C, Maliszewski L, Yan N, O Day E, et al. miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements. Mol Cell. 2009;35:610-25 pubmed publisher
    ..cell-cycle regulatory genes that form a direct interaction network with prominent nodes at genes that enhance (MYC, E2F2, CCNB1, and CDC2) or inhibit (p27Kip1 and VHL) cell-cycle progression...
  62. Zhang R, Wang L, Pan J, Han J. A critical role of E2F transcription factor 2 in proinflammatory cytokines-dependent proliferation and invasiveness of fibroblast-like synoviocytes in rheumatoid Arthritis. Sci Rep. 2018;8:2623 pubmed publisher
    As a transcription factor, E2F2 participates in regulation of numerous genes. To investigate the role and mechnism of E2F2 in RA, expression of E2F2 in synovial tissue was detected...
  63. Zhou Y, Wei R, Zhang L, Chen Y, Lu S, Liang C, et al. Rb is required for retinal angiogenesis and lamination. Cell Death Dis. 2018;9:370 pubmed publisher
    ..Deleting adenovirus E2 promoter binding factor 3 (E2f3), which rescues starburst amacrine cell differentiation, or E2f2, had no effect, but deleting E2f1, which promotes neuronal cell cycle exit and survival, restored retinal ..
  64. Moberg K, Starz M, Lees J. E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry. Mol Cell Biol. 1996;16:1436-49 pubmed
    ..Despite this, a considerable amount of E2F-4 exists as free E2F. In G1 cells, this accounts for almost all of the free activity. Once the cells enter S phase, free E2F is composed of an equal mixture of E2F-4 and E2F-1. ..
  65. Jia R, Lan C, Wang X, Gao C. Integrated analysis of gene expression and copy number variations in MET proto?oncogene?transformed human primary osteoblasts. Mol Med Rep. 2017;: pubmed publisher
    ..compared with control samples, including 784 upregulated genes, such as E2F transcription factor 1 (E2F1) and 2 (E2F2) and 817 downregulated genes, such as retinoblastoma 1 (RB1) and cyclin D1 (CCND1)...
  66. Hong S, Eun J, Choi S, Shen Q, Choi W, Han J, et al. Epigenetic reader BRD4 inhibition as a therapeutic strategy to suppress E2F2-cell cycle regulation circuit in liver cancer. Oncotarget. 2016;7:32628-40 pubmed publisher
    ..analyses with SK-Hep1 liver cancer cells treated with JQ1 to delineate the key player of BRD4 inhibition identified E2F2 as the first line of downstream direct target of BRD4...
  67. Malorni L, Piazza S, Ciani Y, Guarducci C, Bonechi M, Biagioni C, et al. A gene expression signature of retinoblastoma loss-of-function is a predictive biomarker of resistance to palbociclib in breast cancer cell lines and is prognostic in patients with ER positive early breast cancer. Oncotarget. 2016;7:68012-68022 pubmed publisher
    ..a gene expression signature of Rb loss-of-function (RBsig) by identifying genes correlated with E2F1 and E2F2 expression in breast cancers within The Cancer Genome Atlas...
  68. Henssen A, Odersky A, Szymansky A, Seiler M, Althoff K, Beckers A, et al. Targeting tachykinin receptors in neuroblastoma. Oncotarget. 2017;8:430-443 pubmed publisher
    ..Gene expression profiling revealed that TACR1 inhibition repressed E2F2 and induced TP53 signaling...
  69. Hao Z, Sheng Y, Duncan G, Li W, Dominguez C, Sylvester J, et al. K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression. Nat Commun. 2017;8:14003 pubmed publisher
    ..in T cells blocks proliferation because KLF4 accumulates and drives upregulation of its transcriptional targets E2F2 and the cyclin-dependent kinase inhibitors p21 and p27...
  70. Kaikkonen M, Halonen P, Liu O, Turunen T, Pajula J, Moreau P, et al. Genome-Wide Dynamics of Nascent Noncoding RNA Transcription in Porcine Heart After Myocardial Infarction. Circ Cardiovasc Genet. 2017;10: pubmed publisher
    ..differential expression of enhancer RNAs pointed a central role for Krüppel-like factor, MEF2C, ETS, NFY, ATF, E2F2, and NRF1 transcription factors in determining transcriptional responses to ischemia...
  71. Thompson M, Edmonds M, Liang S, McClintock Treep S, Wang X, Li S, et al. miR-31 and miR-17-5p levels change during transformation of follicular lymphoma. Hum Pathol. 2016;50:118-26 pubmed publisher
    ..Two pro-proliferative genes, E2F2 and PI3KC2A, were identified as direct messenger RNA targets of miR-31, suggesting that these may contribute to ..
  72. Gupta R, Forloni M, Bisserier M, Dogra S, Yang Q, Wajapeyee N. Interferon alpha-inducible protein 6 regulates NRASQ61K-induced melanomagenesis and growth. elife. 2016;5: pubmed publisher
    ..NRASQ61K, and knockdown of IFI6 resulted in DNA replication stress due to dysregulated DNA replication via E2F2. This stress consequentially inhibited cellular transformation and melanoma growth via senescence or apoptosis ..
  73. Yang D, Wang J, Xiao M, Zhou T, Shi X. Role of Mir-155 in Controlling HIF-1α Level and Promoting Endothelial Cell Maturation. Sci Rep. 2016;6:35316 pubmed publisher
    ..Moreover, miR-155 was also found to enhance the angiogenic capability of induced ECs by targeting E2F2 transcription factor...
  74. Broustas C, Xu Y, Harken A, Garty G, Amundson S. Comparison of gene expression response to neutron and x-ray irradiation using mouse blood. BMC Genomics. 2017;18:2 pubmed publisher
    ..Of these, 25 genes were consistently downregulated at days 1 and 7, whereas 9 genes, including the transcription factor E2f2, showed bi-directional regulation; being downregulated at day 1, while upregulated at day 7...
  75. Tao T, Shen Q, Luo J, Xu Y, Liang W. MicroRNA-125a Regulates Cell Proliferation Via Directly Targeting E2F2 in Osteosarcoma. Cell Physiol Biochem. 2017;43:768-774 pubmed publisher
    ..The dual-luciferase reporter assay demonstrated that E2F2 is a novel target gene for miR-125a...
  76. van der Watt P, Ngarande E, Leaner V. Overexpression of Kpn?1 and Kpn?2 importin proteins in cancer derives from deregulated E2F activity. PLoS ONE. 2011;6:e27723 pubmed publisher
    ..Mutation analysis confirmed the requirement of E2F sites for promoter activity, and ChIP analysis confirmed E2F2/Dp1 binding to the Kpn?1 and Kpn?2 promoters in vivo...
  77. Karpeta A, Maniecka A, Gregoraszczuk E. Different mechanisms of action of 2, 2', 4, 4'-tetrabromodiphenyl ether (BDE-47) and its metabolites (5-OH-BDE-47 and 6-OH-BDE-47) on cell proliferation in OVCAR-3 ovarian cancer cells and MCF-7 breast cancer cells. J Appl Toxicol. 2016;36:1558-1567 pubmed publisher
    ..In OVCAR-3 cells, the parent compound stimulated cell proliferation by activating CDK1, CDK7, E2F1 and E2F2. Independent of time of exposure, BDE-47 had no effect on ER? and ER? protein expression and ERK1/2 and PKC? ..
  78. Wu C, Zukerberg L, Ngwu C, Harlow E, Lees J. In vivo association of E2F and DP family proteins. Mol Cell Biol. 1995;15:2536-46 pubmed
    ..However, the various E2F/DP complexes display strong differences in the ability to bind to either pRB or p107 in vivo, and the specificity of pRB or p107 binding is mediated by the E2F subunit. ..
  79. Dong Y, Zou J, Su S, Huang H, Deng Y, Wang B, et al. MicroRNA-218 and microRNA-520a inhibit cell proliferation by downregulating E2F2 in hepatocellular carcinoma. Mol Med Rep. 2015;12:1016-22 pubmed publisher
    ..Furthermore, a dual-luciferase reporter assay identified that E2F2 was a novel direct target of miR-218 but not miR-520a in HCC...
  80. Xanthoulis A, Kotsinas A, Tiniakos D, Fiska A, Tentes A, Kyroudi A, et al. The relationship between E2F family members and tumor growth in colorectal adenocarcinomas: A comparative immunohistochemical study of 100 cases. Appl Immunohistochem Mol Morphol. 2014;22:471-7 pubmed publisher
    ..We have collectively investigated the immunohistochemical expression of E2F1, E2F2, and E2F4 transcription factors and their relation to cell kinetic parameters using serial section analysis in a ..
  81. Lee M, Rivera Rivera Y, Moreno C, Saavedra H. The E2F activators control multiple mitotic regulators and maintain genomic integrity through Sgo1 and BubR1. Oncotarget. 2017;8:77649-77672 pubmed publisher
    The E2F1, E2F2, and E2F3a transcriptional activators control proliferation. However, how the E2F activators regulate mitosis to maintain genomic integrity is unclear...
  82. Novy M, Pohn R, Andorfer P, Novy Weiland T, Galos B, Schwarzmayr L, et al. EAPP, a novel E2F binding protein that modulates E2F-dependent transcription. Mol Biol Cell. 2005;16:2181-90 pubmed
    ..Taken together, these data suggest that EAPP modulates E2F-regulated transcription, stimulates proliferation, and may be involved in the malignant transformation of cells. ..
  83. Takeda S, Chen D, Westergard T, Fisher J, Rubens J, Sasagawa S, et al. Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression. Genes Dev. 2006;20:2397-409 pubmed
    ..Lastly, Taspase1(-/-) cells are resistant to oncogenic transformation, and Taspase1 is overexpressed in many cancer cell lines. Thus, Taspase1 may serve as a target for cancer therapeutics. ..
  84. Zhang Y, Han D, Wei W, Cao W, Zhang R, Dong Q, et al. MiR-218 Inhibited Growth and Metabolism of Human Glioblastoma Cells by Directly Targeting E2F2. Cell Mol Neurobiol. 2015;35:1165-73 pubmed publisher
    ..In this study, we found that miR-218 could inhibit growth and metabolism in gliomas by directly targeting E2F2. First, we obtained data from the Chinese Glioma Genome Atlas (CGGA) database to analyze miR-218 expression in ..
  85. Zhao H, Tang W, Chen X, Wang S, Wang X, Xu H, et al. The NAMPT/E2F2/SIRT1 axis promotes proliferation and inhibits p53-dependent apoptosis in human melanoma cells. Biochem Biophys Res Commun. 2017;493:77-84 pubmed publisher
    ..Next, we demonstrate NAMPT regulates the transcription factor E2F family member 2 (E2F2) in the apoptosis process. Downstream, E2F2 control the mRNA and protein levels of SIRT1...
  86. Lin S, Black A, Kostic D, Pajovic S, Hoover C, Azizkhan J. Cell cycle-regulated association of E2F1 and Sp1 is related to their functional interaction. Mol Cell Biol. 1996;16:1668-75 pubmed
    ..Taken together, these data demonstrate that E2F1 and Sp1 both functionally and physically interact; therefore this interaction, Sp1 and E2F1 may regulate transcription of genes containing binding sites for either or both factors. ..
  87. Chen J, Etzel C, Amos C, Zhang Q, Viscofsky N, Lindor N, et al. Genetic variants in the cell cycle control pathways contribute to early onset colorectal cancer in Lynch syndrome. Cancer Causes Control. 2009;20:1769-77 pubmed publisher
    ..We evaluated polymorphisms in a panel of cell cycle-related genes (AURKA, CDKN2A, TP53, E2F2, CCND1, TP73, MDM2, IGF1, and CDKN2B) in 220 MMR gene mutation carriers from 129 families...
  88. Kampik D, Basche M, Luhmann U, Nishiguchi K, Williams J, Greenwood J, et al. In situ regeneration of retinal pigment epithelium by gene transfer of E2F2: a potential strategy for treatment of macular degenerations. Gene Ther. 2017;: pubmed publisher
    ..Here, we used E2F2 to induce RPE cell replication and thereby regeneration...
  89. Hershko T, Chaussepied M, Oren M, Ginsberg D. Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F. Cell Death Differ. 2005;12:377-83 pubmed
    ..Overall, these data provide novel functional links between RB/E2F pathway and p53-induced apoptosis. ..
  90. Li Y, Sturgis E, Zhu L, Cao X, Wei Q, Zhang H, et al. E2F transcription factor 2 variants as predictive biomarkers for recurrence risk in patients with squamous cell carcinoma of the oropharynx. Mol Carcinog. 2017;56:1335-1343 pubmed publisher
    Because E2F transcription factor 2 (E2F2) promoter polymorphisms have been implicated in carcinogenesis and prognosis, we investigated associations between genetic variants in five E2F2 promoter polymorphisms and recurrence risk of ..
  91. Funke Kaiser H, Reichenberger F, Köpke K, Herrmann S, Pfeifer J, Orzechowski H, et al. Differential binding of transcription factor E2F-2 to the endothelin-converting enzyme-1b promoter affects blood pressure regulation. Hum Mol Genet. 2003;12:423-33 pubmed
    ..This study provides the first evidence of a link between the cell-cycle-associated E2F family and BP regulation via a component of the endothelin system. ..
  92. Sylvestre Y, De Guire V, Querido E, Mukhopadhyay U, Bourdeau V, Major F, et al. An E2F/miR-20a autoregulatory feedback loop. J Biol Chem. 2007;282:2135-43 pubmed
    ..We now report that miR-20a, a member of the mir-17-92 cluster, modulates the translation of the E2F2 and E2F3 mRNAs via binding sites in their 3'-untranslated region...