E2F1

Summary

Gene Symbol: E2F1
Description: E2F transcription factor 1
Alias: E2F-1, RBAP1, RBBP3, RBP3, transcription factor E2F1, PBR3, PRB-binding protein E2F-1, RBAP-1, RBBP-3, retinoblastoma-associated protein 1, retinoblastoma-binding protein 3
Species: human
Products:     E2F1

Top Publications

  1. Peart M, Poyurovsky M, Kass E, Urist M, Verschuren E, Summers M, et al. APC/C(Cdc20) targets E2F1 for degradation in prometaphase. Cell Cycle. 2010;9:3956-64 pubmed
    The mechanisms that control E2F-1 activity are complex. We previously showed that Chk1 and Chk2 are required for E2F1 stabilization and p73 target gene induction following DNA damage...
  2. Zauli G, Voltan R, di Iasio M, Bosco R, Melloni E, Sana M, et al. miR-34a induces the downregulation of both E2F1 and B-Myb oncogenes in leukemic cells. Clin Cancer Res. 2011;17:2712-24 pubmed publisher
    To elucidate new molecular mechanisms able to downregulate the mRNA levels of key oncogenes, such as B-Myb and E2F1, in a therapeutic perspective...
  3. Morris E, Ji J, Yang F, Di Stefano L, Herr A, Moon N, et al. E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8. Nature. 2008;455:552-6 pubmed publisher
    The E2F1 transcription factor can promote proliferation or apoptosis when activated, and is a key downstream target of the retinoblastoma tumour suppressor protein (pRB)...
  4. Suh D, Yoon M, Choi K, Kim J. Significance of E2F-1 overexpression in epithelial ovarian cancer. Int J Gynecol Cancer. 2008;18:492-8 pubmed
    ..The results suggest that E2F-1 has a growth-promoting effect in EOC and that E2F-1 overexpression may provide a useful prognostic indicator for EOC. ..
  5. Chau C, Deng Z, Kang H, Lieberman P. Cell cycle association of the retinoblastoma protein Rb and the histone demethylase LSD1 with the Epstein-Barr virus latency promoter Cp. J Virol. 2008;82:3428-37 pubmed publisher
    ..Several previously unknown factors were identified, including the cell cycle regulatory proteins E2F1 and Rb...
  6. Hallstrom T, Mori S, Nevins J. An E2F1-dependent gene expression program that determines the balance between proliferation and cell death. Cancer Cell. 2008;13:11-22 pubmed publisher
    ..During normal proliferation, PI3K/Akt signaling blocks E2F1-induced apoptosis, thus serving to balance proliferation and death...
  7. Ianari A, Natale T, Calo E, Ferretti E, Alesse E, Screpanti I, et al. Proapoptotic function of the retinoblastoma tumor suppressor protein. Cancer Cell. 2009;15:184-94 pubmed publisher
    ..b>E2F1 can also activate proapoptotic genes in response to genotoxic or oncogenic stress...
  8. Dar A, Majid S, De Semir D, Nosrati M, Bezrookove V, Kashani Sabet M. miRNA-205 suppresses melanoma cell proliferation and induces senescence via regulation of E2F1 protein. J Biol Chem. 2011;286:16606-14 pubmed publisher
    ..miRNA target databases predicted E2F1 and E2F5 as putative targets...
  9. Kim K, Oh M, Ki H, Wang T, Bareiss S, Fini M, et al. Identification of E2F1 as a positive transcriptional regulator for delta-catenin. Biochem Biophys Res Commun. 2008;369:414-20 pubmed publisher
    ..Among beta-catenin/LEF-1, Notch1, and E2F1, E2F1 dramatically increased delta-catenin-luciferase activities while beta-catenin/LEF-1 induced only a marginal ..
  10. Xu H, Ren W, Lu C, Zhou G. Characterization of the human IRF-3 promoter and its regulation by the transcription factor E2F1. Mol Biol Rep. 2010;37:3073-80 pubmed publisher
    ..Surprisingly, mutation of this E2F site increased the promoter activity by 2-fold. Furthermore, overexpression of E2F1 reduced the transcription activity by 80%...

Detail Information

Publications70

  1. Peart M, Poyurovsky M, Kass E, Urist M, Verschuren E, Summers M, et al. APC/C(Cdc20) targets E2F1 for degradation in prometaphase. Cell Cycle. 2010;9:3956-64 pubmed
    The mechanisms that control E2F-1 activity are complex. We previously showed that Chk1 and Chk2 are required for E2F1 stabilization and p73 target gene induction following DNA damage...
  2. Zauli G, Voltan R, di Iasio M, Bosco R, Melloni E, Sana M, et al. miR-34a induces the downregulation of both E2F1 and B-Myb oncogenes in leukemic cells. Clin Cancer Res. 2011;17:2712-24 pubmed publisher
    To elucidate new molecular mechanisms able to downregulate the mRNA levels of key oncogenes, such as B-Myb and E2F1, in a therapeutic perspective...
  3. Morris E, Ji J, Yang F, Di Stefano L, Herr A, Moon N, et al. E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8. Nature. 2008;455:552-6 pubmed publisher
    The E2F1 transcription factor can promote proliferation or apoptosis when activated, and is a key downstream target of the retinoblastoma tumour suppressor protein (pRB)...
  4. Suh D, Yoon M, Choi K, Kim J. Significance of E2F-1 overexpression in epithelial ovarian cancer. Int J Gynecol Cancer. 2008;18:492-8 pubmed
    ..The results suggest that E2F-1 has a growth-promoting effect in EOC and that E2F-1 overexpression may provide a useful prognostic indicator for EOC. ..
  5. Chau C, Deng Z, Kang H, Lieberman P. Cell cycle association of the retinoblastoma protein Rb and the histone demethylase LSD1 with the Epstein-Barr virus latency promoter Cp. J Virol. 2008;82:3428-37 pubmed publisher
    ..Several previously unknown factors were identified, including the cell cycle regulatory proteins E2F1 and Rb...
  6. Hallstrom T, Mori S, Nevins J. An E2F1-dependent gene expression program that determines the balance between proliferation and cell death. Cancer Cell. 2008;13:11-22 pubmed publisher
    ..During normal proliferation, PI3K/Akt signaling blocks E2F1-induced apoptosis, thus serving to balance proliferation and death...
  7. Ianari A, Natale T, Calo E, Ferretti E, Alesse E, Screpanti I, et al. Proapoptotic function of the retinoblastoma tumor suppressor protein. Cancer Cell. 2009;15:184-94 pubmed publisher
    ..b>E2F1 can also activate proapoptotic genes in response to genotoxic or oncogenic stress...
  8. Dar A, Majid S, De Semir D, Nosrati M, Bezrookove V, Kashani Sabet M. miRNA-205 suppresses melanoma cell proliferation and induces senescence via regulation of E2F1 protein. J Biol Chem. 2011;286:16606-14 pubmed publisher
    ..miRNA target databases predicted E2F1 and E2F5 as putative targets...
  9. Kim K, Oh M, Ki H, Wang T, Bareiss S, Fini M, et al. Identification of E2F1 as a positive transcriptional regulator for delta-catenin. Biochem Biophys Res Commun. 2008;369:414-20 pubmed publisher
    ..Among beta-catenin/LEF-1, Notch1, and E2F1, E2F1 dramatically increased delta-catenin-luciferase activities while beta-catenin/LEF-1 induced only a marginal ..
  10. Xu H, Ren W, Lu C, Zhou G. Characterization of the human IRF-3 promoter and its regulation by the transcription factor E2F1. Mol Biol Rep. 2010;37:3073-80 pubmed publisher
    ..Surprisingly, mutation of this E2F site increased the promoter activity by 2-fold. Furthermore, overexpression of E2F1 reduced the transcription activity by 80%...
  11. Mussi P, Yu C, O Malley B, Xu J. Stimulation of steroid receptor coactivator-3 (SRC-3) gene overexpression by a positive regulatory loop of E2F1 and SRC-3. Mol Endocrinol. 2006;20:3105-19 pubmed
    ..1, or ACTR) is a transcriptional coactivator for nuclear receptors and certain other transcription factors such as E2F1. SRC-3 is overexpressed in breast cancers, and its overexpression is sufficient to cause mammary carcinomas in vivo...
  12. Lizé M, Pilarski S, Dobbelstein M. E2F1-inducible microRNA 449a/b suppresses cell proliferation and promotes apoptosis. Cell Death Differ. 2010;17:452-8 pubmed publisher
    b>E2F1 is a positive regulator of cell cycle progression and also a potent inducer of apoptosis, especially when activated by DNA damage...
  13. Bindra R, Gibson S, Meng A, Westermark U, Jasin M, Pierce A, et al. Hypoxia-induced down-regulation of BRCA1 expression by E2Fs. Cancer Res. 2005;65:11597-604 pubmed
    ..Furthermore, these findings provide a novel link between E2Fs and the transcriptional response to hypoxia and provide insight into the mechanisms by which the tumor microenvironment can contribute to genetic instability in cancer. ..
  14. Xiao Q, Li L, Xie Y, Tan N, Wang C, Xu J, et al. Transcription factor E2F-1 is upregulated in human gastric cancer tissues and its overexpression suppresses gastric tumor cell proliferation. Cell Oncol. 2007;29:335-49 pubmed
  15. Palaiologou M, Koskinas J, Karanikolas M, Fatourou E, Tiniakos D. E2F-1 is overexpressed and pro-apoptotic in human hepatocellular carcinoma. Virchows Arch. 2012;460:439-46 pubmed publisher
    ..In conclusion, we show that the increased expression of E2F-1 protein in human HCC is correlated with enhanced tumor cell apoptosis supporting a pro-apoptotic role of E2F-1 in human HCC. ..
  16. Wang C, Chen L, Hou X, Li Z, Kabra N, Ma Y, et al. Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nat Cell Biol. 2006;8:1025-31 pubmed
    ..This report shows that the cell-cycle and apoptosis regulator E2F1 induces SirT1 expression at the transcriptional level...
  17. Pickering M, Kowalik T. Rb inactivation leads to E2F1-mediated DNA double-strand break accumulation. Oncogene. 2006;25:746-55 pubmed
    ..We show here that pRb inactivation and the resultant deregulation of one E2F family member, E2F1, leads to DNA double-strand break (DSB) accumulation in normal diploid human cells...
  18. Cassimere E, Pyndiah S, Sakamuro D. The c-MYC-interacting proapoptotic tumor suppressor BIN1 is a transcriptional target for E2F1 in response to DNA damage. Cell Death Differ. 2009;16:1641-53 pubmed publisher
    The E2F1 transcription factor, which was originally identified as a cell-cycle initiator, mediates apoptosis in response to DNA damage...
  19. Höglinger G, Breunig J, Depboylu C, Rouaux C, Michel P, Alvarez Fischer D, et al. The pRb/E2F cell-cycle pathway mediates cell death in Parkinson's disease. Proc Natl Acad Sci U S A. 2007;104:3585-90 pubmed
    ..Inhibition of mitosis-like signals may therefore provide strategies for neuroprotection in PD. ..
  20. Lee J, Park C, Park J, Lim T, Park Y, Lim H, et al. Impact of E2F-1 expression on clinical outcome of gastric adenocarcinoma patients with adjuvant chemoradiation therapy. Clin Cancer Res. 2008;14:82-8 pubmed publisher
    ..459) or disease-free survival (P = 0.447). E2F-1 is a potentially novel independent prognostic factor that may identify gastric cancer patients who will likely benefit from adjuvant chemoradiation therapy following curative resection. ..
  21. Sylvestre Y, De Guire V, Querido E, Mukhopadhyay U, Bourdeau V, Major F, et al. An E2F/miR-20a autoregulatory feedback loop. J Biol Chem. 2007;282:2135-43 pubmed
    ..While the activity of E2F1-3 is tightly controlled by the retinoblastoma family of proteins, the expression of these factors is also regulated ..
  22. Budhavarapu V, White E, Mahanic C, Chen L, Lin F, Lin W. Regulation of E2F1 by APC/C Cdh1 via K11 linkage-specific ubiquitin chain formation. Cell Cycle. 2012;11:2030-8 pubmed publisher
    b>E2F1 is a eukaryotic transcription factor that is known to regulate various cellular pathways such as cell cycle progression, DNA replication, DNA damage responses and induction of apoptosis...
  23. Tyagi S, Chabes A, Wysocka J, Herr W. E2F activation of S phase promoters via association with HCF-1 and the MLL family of histone H3K4 methyltransferases. Mol Cell. 2007;27:107-19 pubmed
    ..Here, we show that the human G1 phase regulator HCF-1 associates with both activator (E2F1 and E2F3a) and repressor (E2F4) E2F proteins, properties that are conserved in insect cells...
  24. Alla V, Engelmann D, Niemetz A, Pahnke J, Schmidt A, Kunz M, et al. E2F1 in melanoma progression and metastasis. J Natl Cancer Inst. 2010;102:127-33 pubmed publisher
    ..Overexpression of the E2F1 transcription factor is common in high-grade tumors that are associated with poor patient survival...
  25. Alonso M, Fueyo J, Shay J, Aldape K, Jiang H, Lee O, et al. Expression of transcription factor E2F1 and telomerase in glioblastomas: mechanistic linkage and prognostic significance. J Natl Cancer Inst. 2005;97:1589-600 pubmed
    ..We examined the functional role of the retinoblastoma-E2F1 pathway in regulating telomerase activity in malignant gliomas...
  26. Zheng C, Ren Z, Wang H, Zhang W, Kalvakolanu D, Tian Z, et al. E2F1 Induces tumor cell survival via nuclear factor-kappaB-dependent induction of EGR1 transcription in prostate cancer cells. Cancer Res. 2009;69:2324-31 pubmed publisher
    b>Transcription factor E2F1 has been implicated in both apoptosis-promoting and apoptosis-suppressing effects. However, factors that mediate its antiapoptotic effects are still not identified...
  27. Minato Y, Tashiro E, Kanai M, Nihei Y, Kodama Y, Imoto M. Transcriptional regulation of a new variant of human platelet-derived growth factor receptor alpha transcript by E2F-1. Gene. 2007;403:89-97 pubmed
    ..Furthermore, epigenetic modulation might be involved in the expression of the type II transcript. Our findings provide new insights into the regulatory mechanism of PDGF receptor alpha transcription in normal and tumor cells. ..
  28. Schayek H, Bentov I, Rotem I, Pasmanik Chor M, Ginsberg D, Plymate S, et al. Transcription factor E2F1 is a potent transactivator of the insulin-like growth factor-I receptor (IGF-IR) gene. Growth Horm IGF Res. 2010;20:68-72 pubmed publisher
    The insulin-like growth factor-I receptor (IGF-IR) plays an important role in cancer development. The E2F1 transcription factor activates S-phase promoting genes and mediates apoptosis...
  29. Gao D, Inuzuka H, Korenjak M, Tseng A, Wu T, Wan L, et al. Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways. Mol Biol Cell. 2009;20:3305-16 pubmed publisher
    ..Here, we report that Cdh1 reciprocally regulates the Rb pathway through competing with E2F1 to bind the hypophosphorylated form of Rb...
  30. Hayami S, Yoshimatsu M, Veerakumarasivam A, Unoki M, Iwai Y, Tsunoda T, et al. Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway. Mol Cancer. 2010;9:59 pubmed publisher
    ..Microarray expression analysis indicated that E2F1 and E2F2 are downstream genes in the KDM5B pathway...
  31. Salon C, Merdzhanova G, Brambilla C, Brambilla E, Gazzeri S, Eymin B. E2F-1, Skp2 and cyclin E oncoproteins are upregulated and directly correlated in high-grade neuroendocrine lung tumors. Oncogene. 2007;26:6927-36 pubmed
    ..0001) and E2F-1 (P=0.0001) status in NE lung tumors. Overall, our data provide the first evidence of a direct and functional interconnection between the E2F-1, Skp2 and cyclin E oncoproteins in HGNE lung carcinomas. ..
  32. Inoue Y, Kitagawa M, Taya Y. Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage. EMBO J. 2007;26:2083-93 pubmed
    ..These results suggest that Ser612 is phosphorylated by Chk1/2 after DNA damage, leading to the formation of pRB-E2F-1. This is the first report that pRB is phosphorylated in vivo by a kinase other than Cdk. ..
  33. Worku D, Jouhra F, Jiang G, Patani N, Newbold R, Mokbel K. Evidence of a tumour suppressive function of E2F1 gene in human breast cancer. Anticancer Res. 2008;28:2135-9 pubmed
    ..b>E2F1 is unique in that it contributes both to the control of cellular proliferation and cellular death...
  34. Xu H, Ren W, Zou L, Wang Y, Jin R, Zhou G. Direct repression of the human IRF-3 promoter by E2F1. Immunogenetics. 2011;63:189-96 pubmed publisher
    ..Here we report that the transcription factor E2F1 negatively regulates the basal transcriptional activity of IRF-3 and deregulates IRF-3 expression at ..
  35. Lee J, Leem S, Lee S, Kim S, Park E, Kim S, et al. Expression signature of E2F1 and its associated genes predict superficial to invasive progression of bladder tumors. J Clin Oncol. 2010;28:2660-7 pubmed publisher
    ..We present a molecular signature that can predict, at diagnosis, the likelihood of bladder cancer progression and, possibly, lead to improvements in patient therapy. ..
  36. Kontaki H, Talianidis I. Lysine methylation regulates E2F1-induced cell death. Mol Cell. 2010;39:152-60 pubmed publisher
    ..regulate DNA damage-induced cell death in a manner opposite to that observed in p53(+/+) cells, via modulation of E2F1 stabilization...
  37. Revenko A, Kalashnikova E, Gemo A, Zou J, Chen H. Chromatin loading of E2F-MLL complex by cancer-associated coregulator ANCCA via reading a specific histone mark. Mol Cell Biol. 2010;30:5260-72 pubmed publisher
    ..We report here that ANCCA directly interacts with E2F1 to E2F3 and that its N terminus interacts with both the N and C termini of E2F1...
  38. Leung J, Ehmann G, Giangrande P, Nevins J. A role for Myc in facilitating transcription activation by E2F1. Oncogene. 2008;27:4172-9 pubmed publisher
    ..b>E2F1 in particular is required for the initial entry to the cell cycle from a quiescent state and is required for the ..
  39. Frame F, Rogoff H, Pickering M, Cress W, Kowalik T. E2F1 induces MRN foci formation and a cell cycle checkpoint response in human fibroblasts. Oncogene. 2006;25:3258-66 pubmed
    Deregulation of the Rb/E2F pathway in human fibroblasts results in an E2F1-mediated apoptosis dependent on Atm, Nbs1, Chk2 and p53...
  40. Racek T, Buhlmann S, Rüst F, Knoll S, Alla V, Pützer B. Transcriptional repression of the prosurvival endoplasmic reticulum chaperone GRP78/BIP by E2F1. J Biol Chem. 2008;283:34305-14 pubmed publisher
    ..b>E2F1, as part of an antitumor safeguard mechanism, promotes apoptosis regardless of functional p53...
  41. Davis J, Wojno K, Daignault S, Hofer M, Kuefer R, Rubin M, et al. Elevated E2F1 inhibits transcription of the androgen receptor in metastatic hormone-resistant prostate cancer. Cancer Res. 2006;66:11897-906 pubmed
    ..In this study, we examined the expression of E2F1 in 667 prostate tissue cores and compared it with the expression of the androgen receptor (AR), a marker of ..
  42. Real S, Meo Evoli N, Espada L, Tauler A. E2F1 regulates cellular growth by mTORC1 signaling. PLoS ONE. 2011;6:e16163 pubmed publisher
    During cell proliferation, growth must occur to maintain homeostatic cell size. Here we show that E2F1 is capable of inducing growth by regulating mTORC1 activity...
  43. Stender J, Frasor J, Komm B, Chang K, Kraus W, Katzenellenbogen B. Estrogen-regulated gene networks in human breast cancer cells: involvement of E2F1 in the regulation of cell proliferation. Mol Endocrinol. 2007;21:2112-23 pubmed
    ..Biochemical analyses confirmed that E2F1 and E2F downstream target genes were increased in MCF-7 and decreased in 231ER+ cells upon estrogen treatment...
  44. Shaw J, Yurkova N, Zhang T, Gang H, Aguilar F, Weidman D, et al. Antagonism of E2F-1 regulated Bnip3 transcription by NF-kappaB is essential for basal cell survival. Proc Natl Acad Sci U S A. 2008;105:20734-9 pubmed publisher
    ..Our data may explain more fundamentally how cells, by selectively inhibiting E2F-1-dependent death gene transcription, avert apoptosis down-stream of the retinoblastoma/E2F-1 cell cycle pathway. ..
  45. Huang C, Liu D, Nakano J, Yokomise H, Ueno M, Kadota K, et al. E2F1 overexpression correlates with thymidylate synthase and survivin gene expressions and tumor proliferation in non small-cell lung cancer. Clin Cancer Res. 2007;13:6938-46 pubmed
    We investigated the clinical significance of E2F1 gene expression in relation to its target genes, thymidylate synthase (TS) and Survivin, in case of non-small-cell lung cancer (NSCLC)...
  46. Lim C, Yao F, Wong J, George J, Xu H, Chiu K, et al. Genome-wide mapping of RELA(p65) binding identifies E2F1 as a transcriptional activator recruited by NF-kappaB upon TLR4 activation. Mol Cell. 2007;27:622-35 pubmed
    ..human monocytic cells, and together with global gene expression profiling, found an overrepresentation of the E2F1-binding motif among RELA-bound loci associated with NF-kappaB target genes...
  47. Zhang H, Li W, Yang S, Li S, Ni J, Jia H. 8-Chloro-adenosine-induced E2F1 promotes p14ARF gene activation in H1299 cells through displacing Sp1 from multiple overlapping E2F1/Sp1 sites. J Cell Biochem. 2009;106:464-72 pubmed publisher
    ..the idea that the ARF promoter has a unique ability to distinguish between aberrant and physiological levels of E2F1. Therefore, the functional characterization of the promoter still needs to be done...
  48. Galbiati L, Mendoza Maldonado R, Gutierrez M, Giacca M. Regulation of E2F-1 after DNA damage by p300-mediated acetylation and ubiquitination. Cell Cycle. 2005;4:930-9 pubmed
    ..Finally, p300-induced E2F-1 ubiquitination is not influenced by RB. ..
  49. Kwon M, Nam E, Cho S, Park H, Shin H, Park J, et al. E2F1 expression predicts outcome in Korean women who undergo surgery for breast carcinoma. Ann Surg Oncol. 2010;17:564-71 pubmed publisher
    The transcriptional factors E2F1 and E2F2 have been reported to be associated with improved chemosensitivity in various cancers...
  50. Docquier A, Harmand P, Fritsch S, Chanrion M, Darbon J, Cavailles V. The transcriptional coregulator RIP140 represses E2F1 activity and discriminates breast cancer subtypes. Clin Cancer Res. 2010;16:2959-70 pubmed publisher
    ..Our aim was to investigate its role in the regulation of E2F1 activity and target genes both in breast cancer cell lines and in tumor biopsies...
  51. Xu X, Bieda M, Jin V, Rabinovich A, Oberley M, Green R, et al. A comprehensive ChIP-chip analysis of E2F1, E2F4, and E2F6 in normal and tumor cells reveals interchangeable roles of E2F family members. Genome Res. 2007;17:1550-61 pubmed
    ..We determined that most E2F1, E2F4, and E2F6 binding sites are located within 2 kb of a transcription start site, in both normal and tumor cells...
  52. Zheng S, Moehlenbrink J, Lu Y, Zalmas L, Sagum C, Carr S, et al. Arginine methylation-dependent reader-writer interplay governs growth control by E2F-1. Mol Cell. 2013;52:37-51 pubmed publisher
    ..Our results define an exquisite level of precision in the reader-writer interplay that governs the biological outcome of E2F-1 activity. ..
  53. Pickering M, Stadler B, Kowalik T. miR-17 and miR-20a temper an E2F1-induced G1 checkpoint to regulate cell cycle progression. Oncogene. 2009;28:140-5 pubmed publisher
    ..due to an accumulation of DNA double-strand breaks, resulting from premature temporal accumulation of the E2F1 transcription factor...
  54. Ou Y, Chung P, Hsu F, Sun T, Chang W, Shieh S. The candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1. EMBO J. 2007;26:3968-80 pubmed
    ..In vitro, BTG3 binds to and inhibits E2F1 through an N-terminal domain including the conserved box A...
  55. Yang G, Zhang R, Chen X, Mu Y, Ai J, Shi C, et al. MiR-106a inhibits glioma cell growth by targeting E2F1 independent of p53 status. J Mol Med (Berl). 2011;89:1037-50 pubmed publisher
    ..that the low expression of miR-106a in human glioma specimens is significantly correlated with high levels of E2F1 protein and high-grade glioma...
  56. Engelmann D, Pützer B. The dark side of E2F1: in transit beyond apoptosis. Cancer Res. 2012;72:571-5 pubmed publisher
    b>E2F1 plays a critical role in cell-cycle progression and the induction of apoptosis in response to DNA damage. The latest evidence has uncovered that this tumor suppressor is most relevant for cancer progression and chemoresistance...
  57. Liao C, Tsai C, Chang W, Lee W, Wang J. RB·E2F1 complex mediates DNA damage responses through transcriptional regulation of ZBRK1. J Biol Chem. 2010;285:33134-43 pubmed publisher
    ..We found that the ZBRK1 promoter contains an authentic E2F-recognition sequence that specifically binds E2F1, but not E2F4 or E2F6, together with chromatin remodeling proteins CtIP and CtBP to form a repression complex that ..
  58. Jenal M, Trinh E, Britschgi C, Britschgi A, Roh V, Vorburger S, et al. The tumor suppressor gene hypermethylated in cancer 1 is transcriptionally regulated by E2F1. Mol Cancer Res. 2009;7:916-22 pubmed publisher
    ..We found that E2F1 strongly activates the full-length HIC1 promoter reporter...
  59. Petrocca F, Visone R, Onelli M, Shah M, Nicoloso M, De Martino I, et al. E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer. Cancer Cell. 2008;13:272-86 pubmed publisher
    Deregulation of E2F1 activity and resistance to TGFbeta are hallmarks of gastric cancer. MicroRNAs (miRNAs) are small noncoding RNAs frequently misregulated in human malignancies...
  60. Wu Z, Zheng S, Li Z, Tan J, Yu Q. E2F1 suppresses Wnt/?-catenin activity through transactivation of ?-catenin interacting protein ICAT. Oncogene. 2011;30:3979-84 pubmed publisher
    ..Although the oncogenic roles of pRb/E2F1 and Wnt/?-catenin pathways have been well studied, the functional interaction between the two pathways has only ..
  61. Nelson M, Reynolds S, Rao U, Goulet A, Feng Y, Beas A, et al. Increased gene copy number of the transcription factor E2F1 in malignant melanoma. Cancer Biol Ther. 2006;5:407-12 pubmed
    ..We have previously shown a unique translocation in malignant melanoma cells der(12)t(12;20). The transcription factor E2F1 maps to 20q11...
  62. Yan L, Wang X, Yang J, Kong F, Lian C, Wei W, et al. Reversal of multidrug resistance in gastric cancer cells by E2F-1 downregulation in vitro and in vivo. J Cell Biochem. 2014;115:34-41 pubmed publisher
    ..E2F-1 may be involved in regulating multiple signaling pathways in reversing MDR, suggesting that E2F-1 may represent a novel target for gastric cancer therapy. ..
  63. Loftus S, Liu G, Carr S, Munro S, La Thangue N. NEDDylation regulates E2F-1-dependent transcription. EMBO Rep. 2012;13:811-8 pubmed publisher
    ..These results identify a new mode of E2F-1 regulation and highlight the emerging role of NEDD8 in regulating transcription factor stability and function. ..
  64. Cartier J, Berthelet J, Marivin A, Gemble S, Edmond V, Plenchette S, et al. Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription. J Biol Chem. 2011;286:26406-17 pubmed publisher
    ..Here, we show that the N-terminal part of cIAP1 directly interacts with the DNA binding domain of the E2F1 transcription factor...
  65. Cho E, Zheng S, Munro S, Liu G, Carr S, Moehlenbrink J, et al. Arginine methylation controls growth regulation by E2F-1. EMBO J. 2012;31:1785-97 pubmed publisher
    ..Our results establish that arginine methylation regulates the biological activity of E2F-1 activity, and raise the possibility that arginine methylation contributes to tumourigenesis by influencing the E2F pathway. ..
  66. O Donnell K, Wentzel E, Zeller K, Dang C, Mendell J. c-Myc-regulated microRNAs modulate E2F1 expression. Nature. 2005;435:839-43 pubmed
    ..Chromatin immunoprecipation experiments show that c-Myc binds directly to this locus. The transcription factor E2F1 is an additional target of c-Myc that promotes cell cycle progression...
  67. Malhotra S, Lapointe J, Salari K, Higgins J, Ferrari M, Montgomery K, et al. A tri-marker proliferation index predicts biochemical recurrence after surgery for prostate cancer. PLoS ONE. 2011;6:e20293 pubmed publisher
    ..signature genes: MKI67 (Ki-67; also a classic proliferation biomarker), TOP2A (DNA topoisomerase II, alpha), and E2F1 (E2F transcription factor 1)...
  68. Ofir M, Hacohen D, Ginsberg D. MiR-15 and miR-16 are direct transcriptional targets of E2F1 that limit E2F-induced proliferation by targeting cyclin E. Mol Cancer Res. 2011;9:440-7 pubmed publisher
    ..we evidence that the miR-15a, miR-16-1 cluster and related miR-15b, miR-16-2 cluster comprise miRs regulated by E2F1, a pivotal transcription factor that can induce both proliferation and cell death...
  69. Gang H, Dhingra R, Wang Y, Mughal W, Gordon J, Kirshenbaum L. Epigenetic regulation of E2F-1-dependent Bnip3 transcription and cell death by nuclear factor-?B and histone deacetylase-1. Pediatr Cardiol. 2011;32:263-6 pubmed publisher
    ..This report highlights the intricate nature between the cellular factors E2F-1 and nuclear factor-?B (NF-?B) and the epigenetic regulation of Bnip3 gene transcription by HDAC1 for cell survival of ventricular myocytes. ..
  70. Yang X, Feng M, Jiang X, Wu Z, Li Z, Aau M, et al. miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A. Genes Dev. 2009;23:2388-93 pubmed publisher
    ..Here we report that E2F1 directly transactivates miR-449a/b...