DYRK1B

Summary

Gene Symbol: DYRK1B
Description: dual specificity tyrosine phosphorylation regulated kinase 1B
Alias: AOMS3, MIRK, dual specificity tyrosine-phosphorylation-regulated kinase 1B, dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1B, minibrain-related kinase, mirk protein kinase
Species: human
Products:     DYRK1B

Top Publications

  1. Mazmanian G, Kovshilovsky M, Yen D, Mohanty A, Mohanty S, Nee A, et al. The zebrafish dyrk1b gene is important for endoderm formation. Genesis. 2010;48:20-30 pubmed publisher
    ..Here we describe the characterization of the zebrafish dyrk1b homolog. We report the detection of a physical interaction between Dyrk1b and Wdr68...
  2. Yang C, Ji D, Weinstein E, Choy E, Hornicek F, Wood K, et al. The kinase Mirk is a potential therapeutic target in osteosarcoma. Carcinogenesis. 2010;31:552-8 pubmed publisher
    ..short hairpin RNA kinase library, screened osteosarcoma cells, identified kinase minibrain-related kinase (Mirk) (Dyrk1B) as a potential target. Knockdown Mirk expression could inhibit cell growth and induce apoptosis...
  3. Gao J, Zheng Z, Rawal B, Schell M, Bepler G, Haura E. Mirk/Dyrk1B, a novel therapeutic target, mediates cell survival in non-small cell lung cancer cells. Cancer Biol Ther. 2009;8:1671-9 pubmed
    ..kinase (Dyrk)/minibrain family of dual-specificity protein kinases and is identical to Dyrk1B. Mirk/Dyrk1B is a serine/threonine kinase that has been found to be upregulated in solid tumors and mediates cell ..
  4. Lim S, Jin K, Friedman E. Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha. J Biol Chem. 2002;277:25040-6 pubmed
    Mirk/Dyrk1B is an arginine-directed serine/threonine protein kinase that is expressed at low levels in most normal tissues but at elevated levels in many tumor cell lines and in normal skeletal muscle...
  5. Ewton D, Hu J, Vilenchik M, Deng X, Luk K, Polonskaia A, et al. Inactivation of mirk/dyrk1b kinase targets quiescent pancreatic cancer cells. Mol Cancer Ther. 2011;10:2104-14 pubmed publisher
    ..Earlier studies showed that levels of the serine/theronine kinase Mirk/dyrk1B are elevated up to 10-fold in quiescent G(0) tumor cells...
  6. Leder S, Czajkowska H, Maenz B, de Graaf K, Barthel A, Joost H, et al. Alternative splicing variants of dual specificity tyrosine phosphorylated and regulated kinase 1B exhibit distinct patterns of expression and functional properties. Biochem J. 2003;372:881-8 pubmed
    ..In the present study, we have characterized three splicing variants of DYRK1B (DYRK1B-p65, DYRK1B-p69 and DYRK1B-p75) with different expression patterns and enzymic activities...
  7. Skurat A, Dietrich A. Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases. J Biol Chem. 2004;279:2490-8 pubmed
    ..Two isoforms of DYRK, DYRK1A and DYRK1B, co-immunoprecipitate with HAN11 when coexpressed in COS cells indicating that the proteins interact in mammalian ..
  8. Miyata Y, Nishida E. DYRK1A binds to an evolutionarily conserved WD40-repeat protein WDR68 and induces its nuclear translocation. Biochim Biophys Acta. 2011;1813:1728-39 pubmed publisher
    ..DYRK1A and DYRK1B, but not DYRK2, DYRK3, or DYRK4, bound to endogenous and expressed WDR68...
  9. Takahashi Yanaga F, Mori J, Matsuzaki E, Watanabe Y, Hirata M, Miwa Y, et al. Involvement of GSK-3beta and DYRK1B in differentiation-inducing factor-3-induced phosphorylation of cyclin D1 in HeLa cells. J Biol Chem. 2006;281:38489-97 pubmed
    ..Depletion of endogenous GSK-3beta and dual-specificity tyrosine phosphorylation regulated kinase 1B (DYRK1B) by RNA interference attenuated the DIF-3-induced cyclin D1 phosphorylation and degradation...

More Information

Publications64

  1. Hu J, Deng H, FRIEDMAN E. Ovarian cancer cells, not normal cells, are damaged by Mirk/Dyrk1B kinase inhibition. Int J Cancer. 2013;132:2258-69 pubmed publisher
    Prior studies had shown that the Mirk/dyrk1B gene is amplified/upregulated in about 75% of ovarian cancers, that protein levels of this kinase are elevated in quiescent G0 cells and that Mirk maintains tumor cells in quiescence by ..
  2. Lauth M, Bergström A, Shimokawa T, Tostar U, Jin Q, Fendrich V, et al. DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS. Nat Struct Mol Biol. 2010;17:718-25 pubmed publisher
    ..transduction involves the RAS effector molecule dual specificity tyrosine phosphorylated and regulated kinase 1B (DYRK1B)...
  3. Jin K, Park S, Ewton D, Friedman E. The survival kinase Mirk/Dyrk1B is a downstream effector of oncogenic K-ras in pancreatic cancer. Cancer Res. 2007;67:7247-55 pubmed
    The kinase Mirk is overexpressed in many resected pancreatic adenocarcinomas and is amplified in a subset of pancreatic cancer cell lines...
  4. Mercer S, Friedman E. Mirk/Dyrk1B: a multifunctional dual-specificity kinase involved in growth arrest, differentiation, and cell survival. Cell Biochem Biophys. 2006;45:303-15 pubmed
    Minibrain-related kinase (Mirk)/dual-specificity tyrosine-regulated kinase (Dyrk)1B is one of the best functionally characterized members of the Dyrk/Minibrain family of dual-specificity kinases...
  5. Hu J, Nakhla H, Friedman E. Transient arrest in a quiescent state allows ovarian cancer cells to survive suboptimal growth conditions and is mediated by both Mirk/dyrk1b and p130/RB2. Int J Cancer. 2011;129:307-18 pubmed publisher
    ..The serine/threonine kinase Mirk/dyrk1B was expressed in each of seven ovarian cancer cell lines and in 21 of 28 resected human ovarian cancers, and ..
  6. Gao J, Yang X, Yin P, Hu W, Liao H, Miao Z, et al. The involvement of FoxO in cell survival and chemosensitivity mediated by Mirk/Dyrk1B in ovarian cancer. Int J Oncol. 2012;40:1203-9 pubmed publisher
    ..serine/threonine kinase which is also known as the dual specificity tyrosine-phosphorylation-regulated kinase 1B (Dyrk1B)...
  7. Lee K, Deng X, Friedman E. Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells. Cancer Res. 2000;60:3631-7 pubmed
    We have cloned a novel gene mirk (minibrain-related kinase) encoding a protein kinase that enables colon carcinoma cells to survive under certain stress conditions...
  8. Deng X, Ewton D, Li S, Naqvi A, Mercer S, Landas S, et al. The kinase Mirk/Dyrk1B mediates cell survival in pancreatic ductal adenocarcinoma. Cancer Res. 2006;66:4149-58 pubmed
    ..The serine/threonine kinase Mirk/Dyrk1B has been shown to be antiapoptotic in rhabdomyosarcomas...
  9. Zou Y, Lim S, Lee K, Deng X, Friedman E. Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M. J Biol Chem. 2003;278:49573-81 pubmed
    Minibrain-related kinase (Mirk)/Dyrk1B is an arginine-directed serine/threonine kinase that is active in skeletal muscle development but is also expressed in various carcinomas...
  10. Jin K, Ewton D, Park S, Hu J, Friedman E. Mirk regulates the exit of colon cancer cells from quiescence. J Biol Chem. 2009;284:22916-25 pubmed publisher
    Mirk/Dyrk1B is a serine/threonine kinase widely expressed in colon cancers. Serum starvation induced HD6 colon carcinoma cells to enter a quiescent G0 state, characterized by a 2N DNA content and a lower RNA content than G1 cells...
  11. Ritterhoff S, Farah C, Grabitzki J, Lochnit G, Skurat A, Schmitz M. The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions. EMBO J. 2010;29:3750-61 pubmed publisher
    ..In vitro experiments showed the direct binding of Han11 to HIPK2, but also to the kinases DYRK1a, DYRK1b and mitogen-activated protein kinase kinase kinase 1 (MEKK1)...
  12. Deng X, Ewton D, Friedman E. Mirk/Dyrk1B maintains the viability of quiescent pancreatic cancer cells by reducing levels of reactive oxygen species. Cancer Res. 2009;69:3317-24 pubmed publisher
    The kinase Mirk/dyrk1B mediated the clonogenic growth of pancreatic cancer cells in earlier studies. It is now shown that Mirk levels increased 7-fold in SU86...
  13. Blom K, Rubin J, Berglund M, Jarvius M, Lenhammar L, Parrow V, et al. Mebendazole-induced M1 polarisation of THP-1 macrophages may involve DYRK1B inhibition. BMC Res Notes. 2019;12:234 pubmed publisher
    ..MBZ potently binds and inhibits Dual specificity tyrosine-phosphorylation-regulated kinase 1B (DYRK1B) with a Kd and an IC50 of 7 and 360 nM, respectively...
  14. Hamilton S, Hutterer C, Egilmezer E, Steingruber M, Milbradt J, Marschall M, et al. Human cytomegalovirus utilises cellular dual-specificity tyrosine phosphorylation-regulated kinases during placental replication. Placenta. 2018;72-73:10-19 pubmed publisher
    ..In this study we provide first evidence that DYRK1A and DYRK1B are utilised during HCMV placental replication...
  15. Singh R, Holz P, Roth K, Hupfer A, Meissner W, Muller R, et al. DYRK1B regulates Hedgehog-induced microtubule acetylation. Cell Mol Life Sci. 2019;76:193-207 pubmed publisher
    ..Mechanistically, Hh pathway activity increases the levels of the MT-associated DYRK1B kinase, resulting in the inhibition of GSK3β through phosphorylation of Serine 9 and the subsequent suppression ..
  16. He M, Gu J, Zhu J, Wang X, Wang C, Duan C, et al. Up-regulation of Dyrk1b promote astrocyte activation following lipopolysaccharide-induced neuroinflammation. Neuropeptides. 2018;69:76-83 pubmed publisher
    Astrocytes become activated in response to different stimulation. Dyrk1b is an arginine-directed serine/threonineprotein kinase that is expressed at elevated levels in many cancers but remains unknown in the pathologies of ..
  17. Widowati E, Bamberg Lemper S, Becker W. Mutational analysis of two residues in the DYRK homology box of the protein kinase DYRK1A. BMC Res Notes. 2018;11:297 pubmed publisher
    ..Two missense mutations in the DH box of human DYRK1B were recently identified as causative of a rare familiar form of metabolic syndrome...
  18. Darwish S, Abdel Halim M, ElHady A, Salah M, Abadi A, Becker W, et al. Development of novel amide-derivatized 2,4-bispyridyl thiophenes as highly potent and selective Dyrk1A inhibitors. Part II: Identification of the cyclopropylamide moiety as a key modification. Eur J Med Chem. 2018;158:270-285 pubmed publisher
    ..2 nM; Dyrk1B = 72...
  19. Darwish S, Abdel Halim M, Salah M, Abadi A, Becker W, Engel M. Development of novel 2,4-bispyridyl thiophene-based compounds as highly potent and selective Dyrk1A inhibitors. Part I: Benzamide and benzylamide derivatives. Eur J Med Chem. 2018;157:1031-1050 pubmed publisher
    ..However, the co-inhibition of other closely related kinases of the same family of protein kinases (e.g. Dyrk1B and Dyrk2) or kinases from other families such as Clk1 limits the use of Dyrk1A inhibitors, as this may cause ..
  20. Kumar K, Man Un Ung P, Wang P, Wang H, Li H, Andrews M, et al. Novel selective thiadiazine DYRK1A inhibitor lead scaffold with human pancreatic β-cell proliferation activity. Eur J Med Chem. 2018;157:1005-1016 pubmed publisher
    ..Compound 3-5 induced human β-cell proliferation at 5 μM while showing selectivity for DYRK1A over DYRK1B and DYRK2 at 10 μM...
  21. Davis S, Sheppard K, Anglesio M, George J, Traficante N, Fereday S, et al. Enhanced GAB2 Expression Is Associated with Improved Survival in High-Grade Serous Ovarian Cancer and Sensitivity to PI3K Inhibition. Mol Cancer Ther. 2015;14:1495-503 pubmed publisher
    ..in the Ovarian Tumor Tissue Analysis cohort for 11 copy number amplified genes: ATP13A4, BMP8B, CACNA1C, CCNE1, DYRK1B, GAB2, PAK4, RAD21, TPX2, ZFP36, and URI...
  22. Janel N, Sarazin M, Corlier F, Corne H, de Souza L, Hamelin L, et al. Plasma DYRK1A as a novel risk factor for Alzheimer's disease. Transl Psychiatry. 2014;4:e425 pubmed publisher
    ..5), lower DYRK1A expression was confirmed. In contrast, no difference was found in levels of DYRK1B, the closest relative of DYRK1A, between AD patients and controls...
  23. Wang X, Zhang Y, Nilsson C, Berven F, Andrén P, Carlsohn E, et al. Association of chromosome 19 to lung cancer genotypes and phenotypes. Cancer Metastasis Rev. 2015;34:217-26 pubmed publisher
    ..oncogene BRD4-NUT, DNA repair genes (ERCC1, ERCC2, XRCC1), TGFβ1 pathway activation genes (TGFB1, LTBP4), Dyrk1B, and potential oncogenesis protector genes such as NFkB pathway inhibition genes (NFKBIB, PPP1R13L) and EGLN2...
  24. Singh R, Dhanyamraju P, Lauth M. DYRK1B blocks canonical and promotes non-canonical Hedgehog signaling through activation of the mTOR/AKT pathway. Oncotarget. 2017;8:833-845 pubmed publisher
    ..Here, we identify the DYRK1B kinase as a mediator between Hh signaling and mTOR/AKT activation...
  25. Bautista E, Vergara P, Segovia J. Iron-induced oxidative stress activates AKT and ERK1/2 and decreases Dyrk1B and PRMT1 in neuroblastoma SH-SY5Y cells. J Trace Elem Med Biol. 2016;34:62-9 pubmed publisher
    ..To determinate the effect of iron on oxidative stress and on cell survival pathways, such as AKT, ERK1/2 and DyrK1B, neuroblastoma SH-SY5Y cells were exposed to different concentration of FeCl2 (iron)...
  26. Lin J, Zhang P, Pang L, Chen J, Sun W, Qi W, et al. [Expression and clinical significance of Dyrk1b in the specimens and cells of cervical lesions]. Zhonghua Fu Chan Ke Za Zhi. 2016;51:40-5 pubmed publisher
    ..explore the expression and clinical significance of dual specificity tyrosine phosphorylation regulated kinase1b (Dyrk1b) in the specimens and cells of cervical lesions...
  27. Masaki S, Kii I, Sumida Y, Kato Sumida T, Ogawa Y, Ito N, et al. Design and synthesis of a potent inhibitor of class 1 DYRK kinases as a suppressor of adipogenesis. Bioorg Med Chem. 2015;23:4434-41 pubmed publisher
    ..It has been recently reported that a gain of function-mutation in the human DYRK1B gene exacerbates metabolic syndrome by enhancing obesity...
  28. El Senduny F, Badria F, El Waseef A, Chauhan S, Halaweish F. Approach for chemosensitization of cisplatin-resistant ovarian cancer by cucurbitacin B. Tumour Biol. 2016;37:685-98 pubmed publisher
    ..glutathione, an increase in ROS through a decrease in the level of dual-specificity tyrosine-regulated kinase (Dyrk1B), decrease in pERK1/2 and pSTAT3 level...
  29. Rüben K, Wurzlbauer A, Walte A, Sippl W, Bracher F, Becker W. Selectivity Profiling and Biological Activity of Novel β-Carbolines as Potent and Selective DYRK1 Kinase Inhibitors. PLoS ONE. 2015;10:e0132453 pubmed publisher
    ..We identified several inhibitors with submicromolar potencies for DYRK1A and selectivity for DYRK1A and DYRK1B over the related kinases DYRK2 and HIPK2...
  30. Lee S, Frattini V, Bansal M, Castano A, Sherman D, Hutchinson K, et al. An ID2-dependent mechanism for VHL inactivation in cancer. Nature. 2016;529:172-7 pubmed publisher
    ..Here we report that DYRK1A and DYRK1B kinases phosphorylate ID2 on threonine 27 (Thr27)...
  31. Zhou N, Yuan S, Wang R, Zhang W, Chen J. Role of dual specificity tyrosine-phosphorylation-regulated kinase 1B (Dyrk1B) in S-phase entry of HPV E7 expressing cells from quiescence. Oncotarget. 2015;6:30745-61 pubmed publisher
    ..Interestingly, we found that Dyrk1B, a dual-specificity kinase and negative regulator of cell proliferation in quiescent cells, was upregulated in E7 ..
  32. Labriere C, Lozach O, Blairvacq M, Meijer L, Guillou C. Further investigation of Paprotrain: Towards the conception of selective and multi-targeted CNS kinase inhibitors. Eur J Med Chem. 2016;124:920-934 pubmed publisher
    ..submicromolar to nanomolar inhibitors were evaluated towards the closest members of the aforementioned kinases: DYRK1B and CLK4, as well as the subfamily CLK2-3...
  33. Deng X, Hu J, Ewton D, Friedman E. Mirk/dyrk1B kinase is upregulated following inhibition of mTOR. Carcinogenesis. 2014;35:1968-76 pubmed publisher
    ..Expression of the reactive oxygen species-controlling kinase Mirk/dyrk1B was increased severalfold by the mammalian target of rapamycin (mTOR) inhibitors RAD001, WYE354 and rapamycin, ..
  34. Ashford A, Oxley D, Kettle J, Hudson K, Guichard S, Cook S, et al. A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3? to phosphorylate cyclin D1 at Thr(286), not Thr(288). Biochem J. 2014;457:43-56 pubmed publisher
    b>DYRK1B (dual-specificity tyrosine phosphorylation-regulated kinase 1B) is amplified in certain cancers and may be an oncogene; however, our knowledge of DYRK1B has been limited by the lack of selective inhibitors...
  35. Ono K, Banno H, Okaniwa M, Hirayama T, Iwamura N, Hikichi Y, et al. Design and synthesis of selective CDK8/19 dual inhibitors: Discovery of 4,5-dihydrothieno[3',4':3,4]benzo[1,2-d]isothiazole derivatives. Bioorg Med Chem. 2017;25:2336-2350 pubmed publisher
    ..cdk19: 4.6%, cdk8: 8.3%, haspin: 23%, dyrk1b: 27%, hip1: 32%)...
  36. Chen Y, Wang S, He Z, Sun F, Huang Y, Ni Q, et al. Dyrk1B overexpression is associated with breast cancer growth and a poor prognosis. Hum Pathol. 2017;66:48-58 pubmed publisher
    b>Dyrk1B, also called minibrain-related kinase (Mirk), is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (Dyrk)/minibrain family of dual-specificity protein kinases...
  37. Glenewinkel F, Cohen M, King C, Kaspar S, Bamberg Lemper S, Mymryk J, et al. The adaptor protein DCAF7 mediates the interaction of the adenovirus E1A oncoprotein with the protein kinases DYRK1A and HIPK2. Sci Rep. 2016;6:28241 pubmed publisher
    ..Our results characterize DCAF7 as a substrate recruiting subunit of DYRK1A and HIPK2 and suggest that it is required for the negative effect of DYRK1A on E1A-induced oncogenic transformation. ..
  38. Keramati A, Fathzadeh M, Go G, Singh R, Choi M, Faramarzi S, et al. A form of the metabolic syndrome associated with mutations in DYRK1B. N Engl J Med. 2014;370:1909-1919 pubmed publisher
    ..A founder mutation was identified in DYRK1B, substituting cysteine for arginine at position 102 in the highly conserved kinase-like domain...
  39. Gruber W, Hutzinger M, Elmer D, Parigger T, Sternberg C, Cegielkowski L, et al. DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance. Oncotarget. 2016;7:7134-48 pubmed publisher
    ..Here we report on the identification of the Dual-Specificity-Tyrosine-Phosphorylation-Regulated Kinase 1B (DYRK1B) as critical positive regulator of HH/GLI signaling downstream of SMO...
  40. Ewton D, Lee K, Deng X, Lim S, Friedman E. Rapid turnover of cell-cycle regulators found in Mirk/dyrk1B transfectants. Int J Cancer. 2003;103:21-8 pubmed
    Mirk/dyrk1B is an arginine-directed protein kinase, which functions as a transcriptional activator and mediates serum-free growth of colon carcinoma cells by an unknown mechanism...
  41. Mercer S, Ewton D, Deng X, Lim S, Mazur T, Friedman E. Mirk/Dyrk1B mediates survival during the differentiation of C2C12 myoblasts. J Biol Chem. 2005;280:25788-801 pubmed
    The kinase Mirk/dyrk1B is essential for the differentiation of C2C12 myoblasts. Mirk reinforces the G0/G1 arrest state in which differentiation occurs by directly phosphorylating and stabilizing p27(Kip1) and destabilizing cyclin D1...
  42. Jin K, Lim S, Mercer S, Friedman E. The survival kinase Mirk/dyrk1B is activated through Rac1-MKK3 signaling. J Biol Chem. 2005;280:42097-105 pubmed
    The serine/threonine kinase Mirk/dyrk1B is activated in several solid tumors where it mediates cell survival, but the mechanism by which Mirk is activated in tumors is unknown...
  43. Zeng Y, Wang Y, Wu Z, Kang K, Peng X, Peng W, et al. miR-9 enhances the transactivation of nuclear factor of activated T cells by targeting KPNB1 and DYRK1B. Am J Physiol Cell Physiol. 2015;308:C720-8 pubmed publisher
    ..KPNB1, a nucleocytoplasmic transporter) and dual-specificity tyrosine phosphorylation-regulated kinase 1B (DYRK1B) were identified as direct targets of miR-9...
  44. Hutterer C, Milbradt J, Hamilton S, Zaja M, Leban J, Henry C, et al. Inhibitors of dual-specificity tyrosine phosphorylation-regulated kinases (DYRK) exert a strong anti-herpesviral activity. Antiviral Res. 2017;143:113-121 pubmed publisher
    ..g. DYRK1B can induce cell cycle arrest, a critical step for the regulation of HCMV replication...
  45. Becker W, Weber Y, Wetzel K, Eirmbter K, Tejedor F, Joost H. Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. J Biol Chem. 1998;273:25893-902 pubmed
    ..that the kinase belongs to a new family of protein kinases comprising at least seven mammalian isoforms (DYRK1A, DYRK1B, DYRK1C, DYRK2, DYRK3, DYRK4A, and DYRK4B), the yeast homolog Yak1p, and the Drosophila kinase minibrain (MNB)...
  46. Becker W. A wake-up call to quiescent cancer cells: potential use of DYRK1B inhibitors in cancer therapy. FEBS J. 2017;: pubmed publisher
    ..The protein kinase DYRK1B is overexpressed in a subset of cancers and maintains cellular quiescence by counteracting G0 /G1
  47. Leder S, Weber Y, Altafaj X, Estivill X, Joost H, Becker W. Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases. Biochem Biophys Res Commun. 1999;254:474-9 pubmed
    ..Here we describe a highly similar homolog, DYRK1B, which is, in contrast to DYRK1A, predominately expressed in muscle and testis...
  48. Lim S, Zou Y, Friedman E. The transcriptional activator Mirk/Dyrk1B is sequestered by p38alpha/beta MAP kinase. J Biol Chem. 2002;277:49438-45 pubmed
    Mirk/Dyrk1B protein kinase was shown in an earlier study to function as a transcriptional activator of HNF1alpha, which Mirk phosphorylates at Ser(249) within its CREB (cAMP-response element-binding protein)-binding protein (CBP) binding ..
  49. Deng X, Ewton D, Mercer S, Friedman E. Mirk/dyrk1B decreases the nuclear accumulation of class II histone deacetylases during skeletal muscle differentiation. J Biol Chem. 2005;280:4894-905 pubmed
    Mirk/dyrk1B is a member of the dyrk/minibrain family of serine/threonine kinases that mediate the transition from growth to differentiation in lower eukaryotes and mammals...
  50. Janumyan Y, Cui Q, Yan L, Sansam C, Valentin M, Yang E. G0 function of BCL2 and BCL-xL requires BAX, BAK, and p27 phosphorylation by Mirk, revealing a novel role of BAX and BAK in quiescence regulation. J Biol Chem. 2008;283:34108-20 pubmed publisher
    ..Stabilization of p27 in G(0) in BCL2 or BCL-x(L) cells was due to phosphorylation of p27 at Ser(10) by the kinase Mirk. In bax(-/-) bak(-/-) cells, total p27 and p27 phosphorylated at Ser(10) were elevated...
  51. Becker W. Emerging role of DYRK family protein kinases as regulators of protein stability in cell cycle control. Cell Cycle. 2012;11:3389-94 pubmed publisher
    ..Other DYRKs also function as cell cycle regulators by modulating the turnover of their target proteins. DYRK1B can induce reversible cell arrest in a quiescent G0 state by targeting cyclin D1 for proteasomal degradation and ..
  52. Pérez Sánchez G, Jimenez A, Quezada Ramírez M, Estudillo E, Ayala Sarmiento A, Mendoza Hernandez G, et al. Annexin A1, Annexin A2, and Dyrk 1B are upregulated during GAS1-induced cell cycle arrest. J Cell Physiol. 2017;: pubmed publisher
    ..Among them, Annexin A1 (Anxa1), Annexin A2 (Anxa2), dual specificity tyrosine-phosphorylation-regulated kinase 1B (Dyrk1B) and Eukaryotic translation initiation factor 3, F (eIf3f) were upregulated at transcriptional level regarding ..
  53. Abu Jhaisha S, Widowati E, Kii I, Sonamoto R, Knapp S, Papadopoulos C, et al. DYRK1B mutations associated with metabolic syndrome impair the chaperone-dependent maturation of the kinase domain. Sci Rep. 2017;7:6420 pubmed publisher
    Two missense mutations of the DYRK1B gene have recently been found to co-segregate with a rare autosomal-dominant form of metabolic syndrome...
  54. Song L, Silva J, Koller A, Rosenthal A, Chen E, Gelmann E. The Tumor Suppressor NKX3.1 Is Targeted for Degradation by DYRK1B Kinase. Mol Cancer Res. 2015;13:913-22 pubmed publisher
    ..1 degradation. This approach identified several candidates, of which DYRK1B, a kinase that is subject to gene amplification and overexpression in other cancers, had the greatest impact on ..
  55. Ashford A, Dunkley T, Cockerill M, Rowlinson R, Baak L, Gallo R, et al. Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome. Cell Mol Life Sci. 2016;73:883-900 pubmed publisher
    The dual-specificity tyrosine-phosphorylation-regulated kinase, DYRK1B, is expressed de novo during myogenesis, amplified or mutated in certain cancers and mutated in familial cases of metabolic syndrome...