DYRK1A

Summary

Gene Symbol: DYRK1A
Description: dual specificity tyrosine phosphorylation regulated kinase 1A
Alias: DYRK, DYRK1, HP86, MNB, MNBH, MRD7, dual specificity tyrosine-phosphorylation-regulated kinase 1A, MNB/DYRK protein kinase, dual specificity YAK1-related kinase, dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, mnb protein kinase homolog hp86, protein kinase minibrain homolog, serine/threonine kinase MNB, serine/threonine-specific protein kinase
Species: human
Products:     DYRK1A

Top Publications

  1. Dahmane N, Ghezala G, Gosset P, Chamoun Z, Dufresne Zacharia M, Lopes C, et al. Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome. Genomics. 1998;48:12-23 pubmed
    ..We identified 27 genuine or highly probable transcriptional units evenly distributed along the CBR-ERG region. Eight of the transcriptional units are known genes. ..
  2. Chen J, Lin J, Tsai F, Meyer T. Dosage of Dyrk1a shifts cells within a p21-cyclin D1 signaling map to control the decision to enter the cell cycle. Mol Cell. 2013;52:87-100 pubmed publisher
    ..we combine live-cell imaging and single-cell analysis to show that increased dosage of chromosome 21-localized Dyrk1a steeply increases G1 cell cycle duration through direct phosphorylation and degradation of cyclin D1 (CycD1)...
  3. Park J, Oh Y, Yoo L, Jung M, Song W, Lee S, et al. Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells. J Biol Chem. 2010;285:31895-906 pubmed publisher
    ..and, more specifically, a regulatory role for dual-specificity tyrosine-(Y) phosphorylation-regulated kinase 1A (Dyrk1A), a DSCR gene product, in embryonic neuronal cell proliferation...
  4. Wang J, Kudoh J, Shintani A, Minoshima S, Shimizu N. Identification of two novel 5' noncoding exons in human MNB/DYRK gene and alternatively spliced transcripts. Biochem Biophys Res Commun. 1998;250:704-10 pubmed
    Previously, the comparison of human MNB/DYRK cDNA sequences with publicly available genomic DNA sequence made a conclusion that MNB/DYRK gene consists of 11 exons spanning 100 kb...
  5. Møller R, Kübart S, Hoeltzenbein M, Heye B, Vogel I, Hansen C, et al. Truncation of the Down syndrome candidate gene DYRK1A in two unrelated patients with microcephaly. Am J Hum Genet. 2008;82:1165-70 pubmed publisher
    ..delay, and febrile seizures/epilepsy who both carry a de novo balanced translocation that truncates the DYRK1A gene at chromosome 21q22.2...
  6. Dowjat W, Adayev T, Kuchna I, Nowicki K, Palminiello S, Hwang Y, et al. Trisomy-driven overexpression of DYRK1A kinase in the brain of subjects with Down syndrome. Neurosci Lett. 2007;413:77-81 pubmed
    ..Among those genes is DYRK1A encoding dual-specificity proline-directed serine/treonine kinase, which, as documented by animal studies, can ..
  7. Murakami N, Xie W, Lu R, Chen Hwang M, Wieraszko A, Hwang Y. Phosphorylation of amphiphysin I by minibrain kinase/dual-specificity tyrosine phosphorylation-regulated kinase, a kinase implicated in Down syndrome. J Biol Chem. 2006;281:23712-24 pubmed
    Minibrain kinase/dual-specificity tyrosine phosphorylation-regulated kinase (Mnb/Dyrk1A) is a proline-directed serine/threonine kinase encoded in the Down syndrome critical region of human chromosome 21...
  8. Litovchick L, Florens L, Swanson S, Washburn M, DeCaprio J. DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly. Genes Dev. 2011;25:801-13 pubmed publisher
    ..Here we report that DYRK1A can specifically phosphorylate LIN52 on serine residue 28, and that this phosphorylation is required for DREAM ..
  9. Wegiel J, Dowjat K, Kaczmarski W, Kuchna I, Nowicki K, Frackowiak J, et al. The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome. Acta Neuropathol. 2008;116:391-407 pubmed publisher
    The gene encoding the minibrain kinase/dual-specificity tyrosine phosphorylated and regulated kinase 1A (DYRK1A) is located in the Down syndrome (DS) critical region of chromosome 21...

More Information

Publications78

  1. Qian W, Jin N, Shi J, Yin X, Jin X, Wang S, et al. Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) enhances tau expression. J Alzheimers Dis. 2013;37:529-38 pubmed publisher
    ..Dual-specificity tyrosine-phosphorylation regulated kinase 1A (Dyrk1A) is overexpressed in Down syndrome and may play a critical role in the early onset of tau pathology in this ..
  2. Courcet J, Faivre L, Malzac P, Masurel Paulet A, Lopez E, Callier P, et al. The DYRK1A gene is a cause of syndromic intellectual disability with severe microcephaly and epilepsy. J Med Genet. 2012;49:731-6 pubmed publisher
    b>DYRK1A plays different functions during development, with an important role in controlling brain growth through neuronal proliferation and neurogenesis...
  3. Jung M, Park J, Ryu Y, Choi S, Yoon S, Kwen M, et al. Regulation of RCAN1 protein activity by Dyrk1A protein-mediated phosphorylation. J Biol Chem. 2011;286:40401-12 pubmed publisher
    Two genes on chromosome 21, namely dual specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) and regulator of calcineurin 1 (RCAN1), have been implicated in some of the phenotypic characteristics of Down syndrome, including ..
  4. Shi J, Zhang T, Zhou C, Chohan M, Gu X, Wegiel J, et al. Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndrome. J Biol Chem. 2008;283:28660-9 pubmed publisher
    ..Here, we demonstrate that Dyrk1A, a kinase encoded by a gene in the DS critical region, phosphorylates alternative splicing factor (ASF) at Ser-227,..
  5. Ryoo S, Cho H, Lee H, Jeong H, Radnaabazar C, Kim Y, et al. Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimer's disease. J Neurochem. 2008;104:1333-44 pubmed
    ..protein involved in the pathogenesis of AD, and dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A (DYRK1A ), a proline-directed protein kinase that plays a critical role in neurodevelopment...
  6. Kimura R, Kamino K, Yamamoto M, Nuripa A, Kida T, Kazui H, et al. The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease. Hum Mol Genet. 2007;16:15-23 pubmed
    ..dose supported genetic risk of 17 markers, of which eight markers were linked to the SAMSN1, PRSS7, NCAM2, RUNX1, DYRK1A and KCNJ6 genes...
  7. Song W, Sternberg L, Kasten Sportes C, Keuren M, Chung S, Slack A, et al. Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome "critical region". Genomics. 1996;38:331-9 pubmed
    ..To study genes potentially responsible for some of these phenotypes, we cloned a human candidate gene (DYRK) from 21q22...
  8. Guimera J, Casas C, Estivill X, Pritchard M. Human minibrain homologue (MNBH/DYRK1): characterization, alternative splicing, differential tissue expression, and overexpression in Down syndrome. Genomics. 1999;57:407-18 pubmed
    The human homologue (MNBH/DYRK1) of the Drosophila minibrain gene maps to human chromosome 21 within the Down syndrome (DS) critical region and is within the region minimally deleted in chromosome 21-linked microcephaly...
  9. Mao J, Maye P, Kogerman P, Tejedor F, Toftgard R, Xie W, et al. Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1. J Biol Chem. 2002;277:35156-61 pubmed
    ..We found that Dyrk1 can substantially enhance Gli1-dependent, but not LEF-1-, c-Jun-, or Elk-dependent, gene transcription...
  10. de Graaf K, Hekerman P, Spelten O, Herrmann A, Packman L, Büssow K, et al. Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors. J Biol Chem. 2004;279:4612-24 pubmed
    ..we identified a new member of the cyclin family, cyclin L2, as a substrate of the nuclear protein kinase DYRK1A. Cyclin L2 contains an N-terminal cyclin domain and a C-terminal arginine/serine-rich domain (RS domain), which is ..
  11. Becker W, Sippl W. Activation, regulation, and inhibition of DYRK1A. FEBS J. 2011;278:246-56 pubmed publisher
    Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a protein kinase with diverse functions in neuronal development and adult brain physiology...
  12. Alvarez M, Estivill X, De La Luna S. DYRK1A accumulates in splicing speckles through a novel targeting signal and induces speckle disassembly. J Cell Sci. 2003;116:3099-107 pubmed
    The protein kinase DYRK1A is distributed throughout the nucleoplasm, accumulating in speckle-like regions. We have found that this punctuated nuclear distribution is determined by the contribution of several elements...
  13. Tejedor F, Hämmerle B. MNB/DYRK1A as a multiple regulator of neuronal development. FEBS J. 2011;278:223-35 pubmed publisher
    MNB/DYRK1A is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family that has been strongly conserved across evolution...
  14. Yabut O, Domogauer J, D ARCANGELO G. Dyrk1A overexpression inhibits proliferation and induces premature neuronal differentiation of neural progenitor cells. J Neurosci. 2010;30:4004-14 pubmed publisher
    b>Dyrk1A is a member of the mammalian Dyrk [dual-specificity tyrosine-(Y)-phosphorylation regulated kinase] family of protein kinases that is expressed at high levels in the brain, but its role in the development and function of this organ ..
  15. Maenz B, Hekerman P, Vela E, Galceran J, Becker W. Characterization of the human DYRK1A promoter and its regulation by the transcription factor E2F1. BMC Mol Biol. 2008;9:30 pubmed publisher
    Overexpression of the human DYRK1A gene due to the presence of a third gene copy in trisomy 21 is thought to play a role in the pathogenesis of Down syndrome...
  16. Hämmerle B, Elizalde C, Galceran J, Becker W, Tejedor F. The MNB/DYRK1A protein kinase: neurobiological functions and Down syndrome implications. J Neural Transm Suppl. 2003;:129-37 pubmed
    ..MNB/DYRK1A is one of these genes...
  17. Ferrer I, Barrachina M, Puig B, Martinez de Lagran M, Marti E, Avila J, et al. Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models. Neurobiol Dis. 2005;20:392-400 pubmed
    b>DYRK1A, dual-specificity tyrosine-regulated kinase 1A, maps to human chromosome 21 within the Down syndrome (DS) critical region...
  18. Chang H, Lin C, Yang C, Yen M, Lai C, Chen Y, et al. Increased expression of Dyrk1a in HPV16 immortalized keratinocytes enable evasion of apoptosis. Int J Cancer. 2007;120:2377-85 pubmed
    ..Using mRNA differential display, RT-PCR and Northern blot methods, we have identified and confirmed that Dyrk1a (dual-specificity tyrosine-phosphorylated and regulated kinase 1A) is present and increased in HPV16 immortalized ..
  19. Himpel S, Tegge W, Frank R, Leder S, Joost H, Becker W. Specificity determinants of substrate recognition by the protein kinase DYRK1A. J Biol Chem. 2000;275:2431-8 pubmed
    b>DYRK1A is a dual-specificity protein kinase that is thought to be involved in brain development...
  20. Lee Y, Ha J, Kim H, Kim Y, Chang E, Song W, et al. Negative feedback Inhibition of NFATc1 by DYRK1A regulates bone homeostasis. J Biol Chem. 2009;284:33343-51 pubmed publisher
    b>DYRK1A is a serine/threonine kinase that has been linked to mental retardation associated with Down syndrome. In the present report, we describe a previously unknown role for DYRK1A in bone homeostasis...
  21. Kim E, Sung J, Lee H, Rhim H, Hasegawa M, Iwatsubo T, et al. Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation. J Biol Chem. 2006;281:33250-7 pubmed
    ..Alpha-synuclein, the major component of LBs, is observed in the brain of Down syndrome (DS) patients with AD. Dyrk1A, a dual specificity tyrosine-regulated kinase (Dyrk) family member, is the mammalian ortholog of the Drosophila ..
  22. Tlili A, Hoischen A, Ripoll C, Benabou E, Badel A, Ronan A, et al. BDNF and DYRK1A are variable and inversely correlated in lymphoblastoid cell lines from Down syndrome patients. Mol Neurobiol. 2012;46:297-303 pubmed publisher
    ..neurotrophin levels, and reduced BDNF has been demonstrated in brains of adult transgenic mice overexpressing Dyrk1a, a candidate gene for Down syndrome phenotypes...
  23. Kelly P, Rahmani Z. DYRK1A enhances the mitogen-activated protein kinase cascade in PC12 cells by forming a complex with Ras, B-Raf, and MEK1. Mol Biol Cell. 2005;16:3562-73 pubmed
    Dual-specificity tyrosine-phosphorylated and regulated kinase 1A (Dyrk1A) is the human homologue of the Drosophila mnb (minibrain) gene. In Drosophila, mnb is involved in postembryonic neurogenesis...
  24. Guo X, Williams J, Schug T, Li X. DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1. J Biol Chem. 2010;285:13223-32 pubmed publisher
    b>DYRK1A (the dual specificity tyrosine phosphorylation-regulated kinase 1A) plays an important role in body growth and brain physiology...
  25. Ryoo S, Jeong H, Radnaabazar C, Yoo J, Cho H, Lee H, et al. DYRK1A-mediated hyperphosphorylation of Tau. A functional link between Down syndrome and Alzheimer disease. J Biol Chem. 2007;282:34850-7 pubmed
    ..on this chromosome is a gene that encodes the dual specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A)...
  26. Woods Y, Rena G, Morrice N, Barthel A, Becker W, Guo S, et al. The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site. Biochem J. 2001;355:597-607 pubmed
    ..homogeneity from rabbit skeletal muscle that phosphorylates FKHR at Ser(329) specifically and identified it as DYRK1A (dual-specificity tyrosine-phosphorylated and regulated kinase 1A)...
  27. Shindoh N, Kudoh J, Maeda H, Yamaki A, Minoshima S, Shimizu Y, et al. Cloning of a human homolog of the Drosophila minibrain/rat Dyrk gene from "the Down syndrome critical region" of chromosome 21. Biochem Biophys Res Commun. 1996;225:92-9 pubmed
    ..The human MNB protein strikingly resembles the recently discovered rat Dyrk protein kinase with a dual specificity...
  28. Guimera J, Casas C, Pucharcos C, Solans A, Domenech A, Planas A, et al. A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region. Hum Mol Genet. 1996;5:1305-10 pubmed
    The minibrain (mnb) gene of Drosophila melanogaster encodes a serine-threonine protein kinase with an essential role in postembryonic neurogenesis...
  29. Chen Hwang M, Chen H, Elzinga M, Hwang Y. Dynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrate. J Biol Chem. 2002;277:17597-604 pubmed
    The minibrain kinase (Mnbk)/dual specificity Yak 1-related kinase 1A (Dyrk1A) gene is implicated in the mental retardation associated with Down's syndrome...
  30. Liu F, Liang Z, Wegiel J, Hwang Y, Iqbal K, Grundke Iqbal I, et al. Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome. FASEB J. 2008;22:3224-33 pubmed publisher
    ..report that the presence of an extra copy of the dual-specificity tyrosine-phosphorylated and regulated kinase 1A (Dyrk1A) gene due to trisomy 21 resulted in overexpression of Dyrk1A and elevated kinase activity in DS brain...
  31. Galceran J, de Graaf K, Tejedor F, Becker W. The MNB/DYRK1A protein kinase: genetic and biochemical properties. J Neural Transm Suppl. 2003;:139-48 pubmed
    ..Evidence is accumulating that DYRK1A, one of the 20 genes located in this region, is an important candidate gene involved in the neurobiological ..
  32. Alvarez M, Altafaj X, Aranda S, De La Luna S. DYRK1A autophosphorylation on serine residue 520 modulates its kinase activity via 14-3-3 binding. Mol Biol Cell. 2007;18:1167-78 pubmed
    ..The family member DYRK1A has been shown to phosphorylate several cytosolic proteins and a number of splicing and transcription factors, ..
  33. Lu M, Zheng L, Han B, Wang L, Wang P, Liu H, et al. REST regulates DYRK1A transcription in a negative feedback loop. J Biol Chem. 2011;286:10755-63 pubmed publisher
    b>DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) has been shown to be involved in learning and memory impairments in Alzheimer disease and Down syndrome...
  34. Becker W, Weber Y, Wetzel K, Eirmbter K, Tejedor F, Joost H. Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. J Biol Chem. 1998;273:25893-902 pubmed
    ..we show that the kinase belongs to a new family of protein kinases comprising at least seven mammalian isoforms (DYRK1A, DYRK1B, DYRK1C, DYRK2, DYRK3, DYRK4A, and DYRK4B), the yeast homolog Yak1p, and the Drosophila kinase minibrain (..
  35. Sung M, Teng C, Yang T. Dissolution enhancement and mathematical modeling of removal of residual trichloroethene in sands by ozonation during flushing with micro-nano-bubble solution. J Contam Hydrol. 2017;202:1-10 pubmed publisher
    Soil flushing using micro-nano-sized bubbles (MNB) in water as the flushing solution was tested in laboratory sand columns for the cleanup of residual trichloroethene (TCE) non-aqueous-phase-liquid (NAPL)...
  36. Younis J, Yazdi V, Izhaki I, Ben Ami M. The association between multinucleated blastomeres and poor ovarian response under the Bologna criteria. J Assist Reprod Genet. 2016;33:885-92 pubmed publisher
    To investigate the occurrence of multinucleated blastomeres (MNB) in poor ovarian response (POR) women defined under the Bologna criteria. This observational study was designed in a prospective controlled manner...
  37. Malinge S, Bliss Moreau M, Kirsammer G, Diebold L, Chlon T, Gurbuxani S, et al. Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome. J Clin Invest. 2012;122:948-62 pubmed publisher
    ..Furthermore, through a functional screening of the trisomic genes, we demonstrated that DYRK1A, which encodes dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A, was a potent megakaryoblastic ..
  38. Kida E, Walus M, Jarzabek K, Palminiello S, Albertini G, Rabe A, et al. Form of dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A nonphosphorylated at tyrosine 145 and 147 is enriched in the nuclei of astroglial cells, adult hippocampal progenitors, and some cholinergic axon terminals. Neuroscience. 2011;195:112-27 pubmed publisher
    ..of evidence indicate that overexpression of dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A) in subjects with trisomy 21 (Down syndrome[DS]) contributes to the abnormal structure and function of the DS ..
  39. Xu D, Shan B, Lee B, Zhu K, Zhang T, Sun H, et al. Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system. elife. 2015;4:e10510 pubmed publisher
  40. Stagni F, Giacomini A, Emili M, Trazzi S, Guidi S, Sassi M, et al. Short- and long-term effects of neonatal pharmacotherapy with epigallocatechin-3-gallate on hippocampal development in the Ts65Dn mouse model of Down syndrome. Neuroscience. 2016;333:277-301 pubmed publisher
    ..EGCG), the major polyphenol of green tea, performs many actions in the brain, including inhibition of DYRK1A, a kinase that is over-expressed in the DS brain and contributes to the DS phenotype...
  41. Vidaki M, Drees F, Saxena T, Lanslots E, Taliaferro M, Tatarakis A, et al. A Requirement for Mena, an Actin Regulator, in Local mRNA Translation in Developing Neurons. Neuron. 2017;95:608-622.e5 pubmed publisher
    ..We find that translation of dyrk1a, a Down syndrome- and autism spectrum disorders-related gene, is dependent on Mena, both in steady-state ..
  42. Laguna A, Aranda S, Barallobre M, Barhoum R, Fernandez E, Fotaki V, et al. The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development. Dev Cell. 2008;15:841-53 pubmed publisher
    ..We show here that DYRK1A (minibrain), a protein kinase essential for normal growth, is a negative regulator of the intrinsic apoptotic ..
  43. Jin N, Yin X, Gu J, Zhang X, Shi J, Qian W, et al. Truncation and Activation of Dual Specificity Tyrosine Phosphorylation-regulated Kinase 1A by Calpain I: A MOLECULAR MECHANISM LINKED TO TAU PATHOLOGY IN ALZHEIMER DISEASE. J Biol Chem. 2015;290:15219-37 pubmed publisher
    ..Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Dyrk1A) lies at the Down syndrome critical region of chromosome 21...
  44. Van Bon B, Coe B, Bernier R, Green C, Gerdts J, Witherspoon K, et al. Disruptive de novo mutations of DYRK1A lead to a syndromic form of autism and ID. Mol Psychiatry. 2016;21:126-32 pubmed publisher
    Dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1 A (DYRK1A) maps to the Down syndrome critical region; copy number increase of this gene is thought to have a major role in the neurocognitive deficits associated with ..
  45. Kruitwagen H, Westendorp B, Viebahn C, Post K, van Wolferen M, Oosterhoff L, et al. DYRK1A is a regulator of S phase entry in hepatic progenitor cells. Stem Cells Dev. 2017;: pubmed publisher
    ..One hit increased the percentage of EdU-positive cells after knockdown: dual specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A)...
  46. Ritterhoff S, Farah C, Grabitzki J, Lochnit G, Skurat A, Schmitz M. The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions. EMBO J. 2010;29:3750-61 pubmed publisher
    ..In vitro experiments showed the direct binding of Han11 to HIPK2, but also to the kinases DYRK1a, DYRK1b and mitogen-activated protein kinase kinase kinase 1 (MEKK1)...
  47. Xu X, Rich E, Seldin D. Murine protein kinase CK2 alpha': cDNA and genomic cloning and chromosomal mapping. Genomics. 1998;48:79-86 pubmed
    ..A polymorphic dinucleotide repeat in the fifth intron allowed us to map the CK2 alpha' gene to murine Chromosome 8. ..
  48. Vázquez Higuera J, Sanchez Juan P, Rodriguez Rodriguez E, Mateo I, Pozueta A, Frank A, et al. DYRK1A genetic variants are not linked to Alzheimer's disease in a Spanish case-control cohort. BMC Med Genet. 2009;10:129 pubmed publisher
    As dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) has been implicated in the abnormal hyperphosphorylation of tau in Alzheimer's disease (AD) brain, and the development of neurofibrillary tangles, we examined the ..
  49. Loaëc N, Attanasio E, Villiers B, Durieu E, Tahtouh T, Cam M, et al. Marine-Derived 2-Aminoimidazolone Alkaloids. Leucettamine B-Related Polyandrocarpamines Inhibit Mammalian and Protozoan DYRK & CLK Kinases. Mar Drugs. 2017;15: pubmed publisher
    ..They inhibited cyclin D1 phosphorylation on a DYRK1A phosphosite in cultured cells...
  50. Oi A, Katayama S, Hatano N, Sugiyama Y, Kameshita I, Sueyoshi N. Subcellular distribution of cyclin-dependent kinase-like 5 (CDKL5) is regulated through phosphorylation by dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A). Biochem Biophys Res Commun. 2017;482:239-245 pubmed publisher
    ..directly phosphorylates CDKL5, identifying it as dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A), an enzyme binding to and phosphorylating CDKL5...
  51. Lee M, Rusin S, Jenkins N, Kettenbach A, Moseley J. Mechanisms Connecting the Conserved Protein Kinases Ssp1, Kin1, and Pom1 in Fission Yeast Cell Polarity and Division. Curr Biol. 2018;28:84-92.e4 pubmed publisher
    ..for cell polarity and cytokinesis (Tea4, Mod5, Cdc15, and Cyk3) were also phosphorylated by a second kinase, the DYRK family member Pom1 [8]...
  52. Lubelwana Hafver T, Wanichawan P, Manfra O, de Souza G, Lunde M, Martinsen M, et al. Mapping the in vitro interactome of cardiac sodium (Na+ )-calcium (Ca2+ ) exchanger 1 (NCX1). Proteomics. 2017;17: pubmed publisher
    ..Ten novel protein partners (DYRK1A, PPP2R2A, SNTB1, DMD, RABGGTA, DNAJB4, BAG3, PDE3A, POPDC2, STK39) were validated for binding to NCX1, and two ..
  53. Hutterer C, Milbradt J, Hamilton S, Zaja M, Leban J, Henry C, et al. Inhibitors of dual-specificity tyrosine phosphorylation-regulated kinases (DYRK) exert a strong anti-herpesviral activity. Antiviral Res. 2017;143:113-121 pubmed publisher
    ..Members of the DYRK family are capable of phosphorylating a number of substrate proteins, including regulators of the cell cycle, e.g...
  54. Wegiel J, Kaczmarski W, Barua M, Kuchna I, Nowicki K, Wang K, et al. Link between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndrome. J Neuropathol Exp Neurol. 2011;70:36-50 pubmed publisher
    ..in overexpression of the minibrain kinase/dual-specificity tyrosine phosphorylated and regulated kinase 1A gene (DYRK1A). DYRK1A phosphorylates cytoplasmic tau protein and appears in intraneuronal neurofibrillary tangles (NFTs)...
  55. Nanda G, Vallmuur K, LEHTO M. Improving autocoding performance of rare categories in injury classification: Is more training data or filtering the solution?. Accid Anal Prev. 2018;110:115-127 pubmed publisher
    ..the size of training data on the prediction performance of three classical ML models: Multinomial Naïve Bayes (MNB), Support Vector Machine (SVM) and Logistic Regression (LR), and b) studied the effect of filtering based on ..
  56. Laguna A, Barallobre M, Marchena M, Mateus C, Ramírez E, Martinez Cue C, et al. Triplication of DYRK1A causes retinal structural and functional alterations in Down syndrome. Hum Mol Genet. 2013;22:2775-84 pubmed publisher
    ..Moreover, we show that mice bearing only one additional copy of Dyrk1a have the same retinal phenotype as Ts65Dn mice and normalization of Dyrk1a gene copy number in Ts65Dn mice ..
  57. Wang P, Wang L, Chen L, Sun X. Dual-specificity tyrosine-phosphorylation regulated kinase 1A Gene Transcription is regulated by Myocyte Enhancer Factor 2D. Sci Rep. 2017;7:7240 pubmed publisher
    Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) is localized in the Down syndrome critical region of chromosome 21...
  58. Farooq M, Hashmi A, Khan I, Hong J. Superconductivity in two-dimensional ferromagnetic MnB. Sci Rep. 2017;7:17101 pubmed publisher
    Using the universal structure predictor algorithm, we proposed that two-dimensional MnB structures with p4mmm (?-MnB) and pmma (?-MnB) symmetries could be synthesized...
  59. Canzonetta C, Mulligan C, Deutsch S, Ruf S, O Doherty A, Lyle R, et al. DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome. Am J Hum Genet. 2008;83:388-400 pubmed publisher
    ..Using partially trisomic ES cells, we map this effect to a three-gene segment of HSA21, containing DYRK1A. We independently identify the same locus as the most significant eQTL controlling REST expression in the human ..
  60. Booiman T, Loukachov V, van Dort K, van t Wout A, Kootstra N. DYRK1A Controls HIV-1 Replication at a Transcriptional Level in an NFAT Dependent Manner. PLoS ONE. 2015;10:e0144229 pubmed publisher
    ..present study we analyzed the effect of host factor dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) on HIV-1 replication. We show that DYRK1A controls HIV-1 replication by regulating provirus transcription...
  61. Ji J, Lee H, Argiropoulos B, Dorrani N, Mann J, Martinez Agosto J, et al. DYRK1A haploinsufficiency causes a new recognizable syndrome with microcephaly, intellectual disability, speech impairment, and distinct facies. Eur J Hum Genet. 2015;23:1473-81 pubmed publisher
    Dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1 A (DYRK1A ) is a highly conserved gene located in the Down syndrome critical region. It has an important role in early development and regulation of neuronal proliferation...
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