Gene Symbol: DYNLL2
Description: dynein light chain LC8-type 2
Alias: DNCL1B, Dlc2, RSPH22, dynein light chain 2, cytoplasmic, 8 kDa dynein light chain b, DLC8b, radial spoke 22 homolog
Species: human
Products:     DYNLL2

Top Publications

  1. Wolosz D, Walczak A, Szparecki G, Dwojak M, Winiarska M, Wolinska E, et al. Deleted in Liver Cancer 2 (DLC2) protein expression in hepatocellular carcinoma. Eur J Histochem. 2019;63: pubmed publisher
    ..The function of its close family relative, DLC2 is unequivocal...
  2. Hamada Y, Tsurumi Y, Nozaki S, Katoh Y, Nakayama K. Interaction of WDR60 intermediate chain with TCTEX1D2 light chain of the dynein-2 complex is crucial for ciliary protein trafficking. Mol Biol Cell. 2018;29:1628-1639 pubmed publisher
    ..The dynein-2 complex can be divided into three subcomplexes, namely DYNC2H1-DYNC2LI1, WDR34-DYNLL1/DYNLL2-DYNLRB1/DYNLRB2, and WDR60-TCTEX1D2-DYNLT1/DYNLT3...
  3. Goggolidou P, Stevens J, Agueci F, Keynton J, Wheway G, Grimes D, et al. ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis. Development. 2014;141:3966-77 pubmed publisher
    ..DYNLL1 in cultured cells recapitulated the in vivo ciliogenesis phenotypes and expression of DYNLL1 or the related DYNLL2 rescued the effects of loss of ATMIN, demonstrating that ATMIN primarily promotes ciliogenesis by regulating ..
  4. Vitiello E, Ferreira J, Maiato H, Balda M, Matter K. The tumour suppressor DLC2 ensures mitotic fidelity by coordinating spindle positioning and cell-cell adhesion. Nat Commun. 2014;5:5826 pubmed publisher
    ..Here we demonstrate that the tumour suppressor DLC2, a negative regulator of Cdc42, and the interacting kinesin Kif1B coordinate cell junction maintenance and planar ..
  5. Asante D, Stevenson N, Stephens D. Subunit composition of the human cytoplasmic dynein-2 complex. J Cell Sci. 2014;127:4774-87 pubmed publisher
    ..also known as DYNLRB1) and roadblock-2 (also known as DYNLRB2), and LC8-1 and LC8-2 light chains (DYNLL1 and DYNLL2, respectively). We also find that NudCD3 associates with dynein-2 as it does with dynein-1...
  6. Haque Bhuiyan M, Mohibbullah M, Hannan M, Hong Y, Han C, Kim Y, et al. The neuritogenic and synaptogenic effects of the ethanolic extract of radix Puerariae in cultured rat hippocampal neurons. J Ethnopharmacol. 2015;173:172-82 pubmed publisher
    ..study revealed that RPE and puerarin both up-regulated a number of proteins, including dynein light chain 2 (DLC2) and elongation factor 2 (EF2), which are associated with neuritogenesis and synaptic potentiation, respectively...
  7. Suyama S, Kodaira Hirano M, Otgon Uul Z, Ueta Y, Nakata M, Yada T. Fasted/fed states regulate postsynaptic hub protein DYNLL2 and glutamatergic transmission in oxytocin neurons in the hypothalamic paraventricular nucleus. Neuropeptides. 2016;56:115-23 pubmed publisher
    ..In Oxt neurons, dynein light chain 2 (DYNLL2), a protein suggested to be implicated in the NMDA receptor trafficking to the postsynaptic site, was increased ..
  8. Wang D, Qian X, Rajaram M, Durkin M, Lowy D. DLC1 is the principal biologically-relevant down-regulated DLC family member in several cancers. Oncotarget. 2016;7:45144-45157 pubmed publisher
    ..members of the Deleted in Liver Cancer (DLC) family of Rho-GAPs, which comprises three closely related genes (DLC1, DLC2, and DLC3) that are down-regulated in a wide range of malignancies...
  9. Takaoka M, Ito S, Miki Y, Nakanishi A. FKBP51 regulates cell motility and invasion via RhoA signaling. Cancer Sci. 2017;108:380-389 pubmed publisher
    ..e., deleted in liver cancer 1 (DLC1) and deleted in liver cancer 2 (DLC2), using immunoprecipitation and mass spectrometry...

More Information


  1. Kreko Pierce T, Eaton B. The Drosophila LC8 homolog cut up specifies the axonal transport of proteasomes. J Cell Sci. 2017;130:3388-3398 pubmed publisher
    ..analyses reveals that the Drosophila homolog of the LC8 dynein light chains (mammalian DYNLL1 and DYNLL2), called Cut up, binds proteasomes and functions specifically during their transport...
  2. Lei K, Davis R. JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis. Proc Natl Acad Sci U S A. 2003;100:2432-7 pubmed
    ..These proapoptotic BH3-only proteins therefore provide a molecular link between the JNK signal transduction pathway and the Bax/Bak-dependent mitochondrial apoptotic machinery. ..
  3. Bodor A, Radnai L, Hetényi C, Rapali P, Láng A, Kövér K, et al. DYNLL2 dynein light chain binds to an extended linear motif of myosin 5a tail that has structural plasticity. Biochemistry. 2014;53:7107-22 pubmed publisher
    ..Among the binding partners of DYNLL2, myosin 5a (myo5a) is a motor protein involved in cargo transport...
  4. Pfister K, Fisher E, Gibbons I, Hays T, Holzbaur E, McIntosh J, et al. Cytoplasmic dynein nomenclature. J Cell Biol. 2005;171:411-3 pubmed
    ..This nomenclature recognizes the two distinct cytoplasmic dynein complexes and has the flexibility to accommodate the discovery of new subunits and isoforms. ..
  5. Radnai L, Rapali P, Hódi Z, Süveges D, Molnar T, Kiss B, et al. Affinity, avidity, and kinetics of target sequence binding to LC8 dynein light chain isoforms. J Biol Chem. 2010;285:38649-57 pubmed publisher
    ..Here, we compared the kinetic and thermodynamic parameters of binding of both mammalian isoforms, DYNLL1 and DYNLL2, to two putative consensus binding motifs (KXTQTX and XG(I/V)QVD) and report only subtle differences...
  6. Naisbitt S, Valtschanoff J, Allison D, Sala C, Kim E, Craig A, et al. Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein. J Neurosci. 2000;20:4524-34 pubmed
    ..A yeast two-hybrid screen with GKAP isolated DLC2, a novel protein 93% identical to the previously cloned 8 kDa dynein light chain (DLC1)...
  7. Fuhrmann J, Kins S, Rostaing P, El Far O, Kirsch J, Sheng M, et al. Gephyrin interacts with Dynein light chains 1 and 2, components of motor protein complexes. J Neurosci. 2002;22:5393-402 pubmed
    ..Because Dlc-1 and Dlc-2 have been described as stoichiometric components of cytoplasmic dynein and myosin-Va complexes, our results suggest that motor proteins are involved in the subcellular localization of gephyrin. ..
  8. Puthalakath H, Villunger A, O Reilly L, Beaumont J, Coultas L, Cheney R, et al. Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. Science. 2001;293:1829-32 pubmed
    ..Thus, at least two mammalian BH3-only proteins, Bmf and Bim, function to sense intracellular damage by their localization to distinct cytoskeletal structures. ..
  9. Haraguchi K, Satoh K, Yanai H, Hamada F, Kawabuchi M, Akiyama T. The hDLG-associated protein DAP interacts with dynein light chain and neuronal nitric oxide synthase. Genes Cells. 2000;5:905-911 pubmed
    ..Furthermore, DAP interacted with nNOS and recruited it into the Triton X-100-insoluble fraction of transfected cells. DAP interacts directly with DLC and nNOS, and links these proteins to the NMDA-R-PSD-95 complex. ..
  10. Day C, Puthalakath H, Skea G, Strasser A, Barsukov I, Lian L, et al. Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands. Biochem J. 2004;377:597-605 pubmed
    ..In vivo DLC2 is found exclusively as a component of the myosin V motor complex and Bmf binds DLC2 selectively...
  11. Simonis N, Rual J, Lemmens I, Boxus M, Hirozane Kishikawa T, Gatot J, et al. Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses. Retrovirology. 2012;9:26 pubmed publisher
  12. Basak P, Leslie H, Dillon R, Muller W, Raouf A, Mowat M. In vivo evidence supporting a metastasis suppressor role for Stard13 (Dlc2) in ErbB2 (Neu) oncogene induced mouse mammary tumours. Genes Chromosomes Cancer. 2017;: pubmed publisher
    ..Altogether our results indicate that Stard13 acts as a metastasis suppressor rather than a tumor suppressor gene, in Neu oncogene induced mammary tumorigenesis. This article is protected by copyright. All rights reserved...