DYNLL1

Summary

Gene Symbol: DYNLL1
Description: dynein light chain LC8-type 1
Alias: DLC1, DLC8, DNCL1, DNCLC1, LC8, LC8a, PIN, hdlc1, dynein light chain 1, cytoplasmic, 8 kDa dynein light chain, cytoplasmic dynein light polypeptide, dynein, cytoplasmic, light polypeptide 1, protein inhibitor of neuronal nitric oxide synthase
Species: human
Products:     DYNLL1

Top Publications

  1. Song C, Wen W, Rayala S, Chen M, Ma J, Zhang M, et al. Serine 88 phosphorylation of the 8-kDa dynein light chain 1 is a molecular switch for its dimerization status and functions. J Biol Chem. 2008;283:4004-13 pubmed
    Dynein light chain 1 (DLC1, also known as DYNLL1, LC8, and PIN), a ubiquitously expressed and highly conserved protein, participates in a variety of essential intracellular events...
  2. Jaffrey S, Snyder S. PIN: an associated protein inhibitor of neuronal nitric oxide synthase. Science. 1996;274:774-7 pubmed
    ..This inhibitor, designated PIN, appears to be one of the most conserved proteins in nature, showing 92 percent amino acid identity with the ..
  3. Tochio H, Ohki S, Zhang Q, Li M, Zhang M. Solution structure of a protein inhibitor of neuronal nitric oxide synthase. Nat Struct Biol. 1998;5:965-9 pubmed
    The structure of the neuronal nitric oxide synthase inhibitory protein, PIN (protein inhibitor of nNOS), has been determined by NMR spectroscopy...
  4. Faulkner N, Dujardin D, Tai C, Vaughan K, O Connell C, Wang Y, et al. A role for the lissencephaly gene LIS1 in mitosis and cytoplasmic dynein function. Nat Cell Biol. 2000;2:784-91 pubmed
    ..We conclude that LIS1 participates in a subset of dynein functions, and may regulate the division of neuronal progenitor cells in the developing brain. ..
  5. Lightcap C, Kari G, Arias Romero L, Chernoff J, Rodeck U, Williams J. Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development. PLoS ONE. 2009;4:e6025 pubmed publisher
    ..In addition, the dynein light chain, LC8, has been described to cooperate with Pak1 in malignant transformation of breast cancer cells...
  6. Rapali P, Radnai L, Süveges D, Harmat V, Tölgyesi F, Wahlgren W, et al. Directed evolution reveals the binding motif preference of the LC8/DYNLL hub protein and predicts large numbers of novel binders in the human proteome. PLoS ONE. 2011;6:e18818 pubmed publisher
    b>LC8 dynein light chain (DYNLL) is a eukaryotic hub protein that is thought to function as a dimerization engine. Its interacting partners are involved in a wide range of cellular functions...
  7. Rodriguez Crespo I, Straub W, Gavilanes F, Ortiz de Montellano P. Binding of dynein light chain (PIN) to neuronal nitric oxide synthase in the absence of inhibition. Arch Biochem Biophys. 1998;359:297-304 pubmed
    b>PIN, an 89-amino-acid polypeptide found in a rat hippocampal cDNA library using the yeast two-hybrid system and various neuronal nitric oxide synthase (nNOS) fragments as bait, was reported to be an inhibitor of nNOS (Science 274, 774-..
  8. Lo K, Naisbitt S, Fan J, Sheng M, Zhang M. The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif. J Biol Chem. 2001;276:14059-66 pubmed
    ..Using purified recombinant proteins, we show that the highly conserved 8-kDa light chain (DLC8) binds to the intermediate chain of the dynein complex...
  9. Fan J, Zhang Q, Tochio H, Li M, Zhang M. Structural basis of diverse sequence-dependent target recognition by the 8 kDa dynein light chain. J Mol Biol. 2001;306:97-108 pubmed
    ..than acting as an essential component of the dynein motor complex, the 89-residue subunit of dynein light chain (DLC8) also regulates a number of other biological events by binding to various proteins and enzymes...

More Information

Publications103 found, 100 shown here

  1. Wong R, Blobel G, Coutavas E. Rae1 interaction with NuMA is required for bipolar spindle formation. Proc Natl Acad Sci U S A. 2006;103:19783-7 pubmed
    ..These data point to the Rae1-NuMA interaction as a critical element for normal spindle formation in mitosis. ..
  2. García Mayoral M, Martínez Moreno M, Albar J, Rodríguez Crespo I, Bruix M. Structural basis for the interaction between dynein light chain 1 and the glutamate channel homolog GRINL1A. FEBS J. 2010;277:2340-50 pubmed publisher
    Human dynein light chain 1 (DYNLL1) is a dimeric 89-residue protein that is known to be involved in cargo binding within the dynein multiprotein complex...
  3. Raaijmakers J, Tanenbaum M, Medema R. Systematic dissection of dynein regulators in mitosis. J Cell Biol. 2013;201:201-15 pubmed publisher
  4. Crepieux P, Kwon H, Leclerc N, Spencer W, Richard S, Lin R, et al. I kappaB alpha physically interacts with a cytoskeleton-associated protein through its signal response domain. Mol Cell Biol. 1997;17:7375-85 pubmed
  5. Puthalakath H, Huang D, O Reilly L, King S, Strasser A. The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. Mol Cell. 1999;3:287-96 pubmed
    ..In healthy cells, most Bim molecules were bound to LC8 cytoplasmic dynein light chain and thereby sequestered to the microtubule-associated dynein motor complex...
  6. Lei K, Davis R. JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis. Proc Natl Acad Sci U S A. 2003;100:2432-7 pubmed
    ..These proapoptotic BH3-only proteins therefore provide a molecular link between the JNK signal transduction pathway and the Bax/Bak-dependent mitochondrial apoptotic machinery. ..
  7. Day C, Puthalakath H, Skea G, Strasser A, Barsukov I, Lian L, et al. Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands. Biochem J. 2004;377:597-605 pubmed
    ..On the other hand, Bim interacts with DLC1 (LC8), an integral component of the dynein motor complex...
  8. Dick T, Ray K, Salz H, Chia W. Cytoplasmic dynein (ddlc1) mutations cause morphogenetic defects and apoptotic cell death in Drosophila melanogaster. Mol Cell Biol. 1996;16:1966-77 pubmed
    ..Cloning of the human homolog of the ddlc1 gene, hdlc1, demonstrates that the dynein light-chain 1 is highly conserved in flies and humans...
  9. Liang J, Jaffrey S, Guo W, Snyder S, Clardy J. Structure of the PIN/LC8 dimer with a bound peptide. Nat Struct Biol. 1999;6:735-40 pubmed
    ..as neuronal nitric oxide synthase inhibitory protein, PIN (protein inhibitor of nNOS), and also as the 8 kDa dynein light chain (LC8) has been solved by X-ray diffraction...
  10. Lo K, Kan H, Chan L, Xu W, Wang K, Wu Z, et al. The 8-kDa dynein light chain binds to p53-binding protein 1 and mediates DNA damage-induced p53 nuclear accumulation. J Biol Chem. 2005;280:8172-9 pubmed
    ..We report here that the 8-kDa light chain (LC8) of dynein binds to p53-binding protein 1 (53BP1)...
  11. Naisbitt S, Valtschanoff J, Allison D, Sala C, Kim E, Craig A, et al. Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein. J Neurosci. 2000;20:4524-34 pubmed
    ..A yeast two-hybrid screen with GKAP isolated DLC2, a novel protein 93% identical to the previously cloned 8 kDa dynein light chain (DLC1)...
  12. Jacob Y, Badrane H, Ceccaldi P, Tordo N. Cytoplasmic dynein LC8 interacts with lyssavirus phosphoprotein. J Virol. 2000;74:10217-22 pubmed
    Using a yeast two-hybrid human brain cDNA library screen, the cytoplasmic dynein light chain (LC8), a 10-kDa protein, was found to interact strongly with the phosphoprotein (P) of two lyssaviruses: rabies virus (genotype 1) and Mokola ..
  13. Rayala S, den Hollander P, Manavathi B, Talukder A, Song C, Peng S, et al. Essential role of KIBRA in co-activator function of dynein light chain 1 in mammalian cells. J Biol Chem. 2006;281:19092-9 pubmed
    Recently dynein light chain 1 (DLC1), a cytoskeleton signaling component, has been shown to interact with and transactivate estrogen receptor-alpha (ER), leading to increased expression of ER target genes and growth stimulation of breast ..
  14. Herzig R, Andersson U, Scarpulla R. Dynein light chain interacts with NRF-1 and EWG, structurally and functionally related transcription factors from humans and drosophila. J Cell Sci. 2000;113 Pt 23:4263-73 pubmed
    ..Thus, the interaction with dynein light chain is conserved between transcription factors that are structurally and functionally similar between humans and Drosophila. ..
  15. Bielli A, Thörnqvist P, Hendrick A, Finn R, Fitzgerald K, McCaffrey M. The small GTPase Rab4A interacts with the central region of cytoplasmic dynein light intermediate chain-1. Biochem Biophys Res Commun. 2001;281:1141-53 pubmed
    ..Additionally, GFPRab4A endosomes localize to microtubules and are redistributed by nocodazole treatment. This is the first described interaction between cytoplasmic dynein, a retrograde motor protein, and a Rab protein. ..
  16. Kaiser F, Tavassoli K, van den Bemd G, Chang G, Horsthemke B, Moroy T, et al. Nuclear interaction of the dynein light chain LC8a with the TRPS1 transcription factor suppresses the transcriptional repression activity of TRPS1. Hum Mol Genet. 2003;12:1349-58 pubmed
    ..We found that two distinct regions of TRPS1 can physically interact with the dynein light chain 8 protein, LC8a, that are at least 458 amino acids apart from each other...
  17. Vadlamudi R, Bagheri Yarmand R, Yang Z, Balasenthil S, Nguyen D, Sahin A, et al. Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes. Cancer Cell. 2004;5:575-85 pubmed
    We identified dynein light chain 1 (DLC1) as a physiologic substrate of p21-activated kinase 1 (Pak1). Pak1-DLC1 interaction plays an essential role in cell survival, which depends on Pak1's phosphorylation of DLC1 on Ser88...
  18. Giordano F, Zicca A, Barba C, Guerrini R, Genitori L. Vagus nerve stimulation: Surgical technique of implantation and revision and related morbidity. Epilepsia. 2017;58 Suppl 1:85-90 pubmed publisher
    ..The actual device is composed of a wire with three helical contacts (two active contacts, one anchoring) and a one-pin battery. VNS is usually started 2 weeks after implantation with recommended settings of stimulation (1.0-2...
  19. Tao J, Hou Y, Ma X, Liu D, Tong Y, Zhou H, et al. An integrated global chemomics and system biology approach to analyze the mechanisms of the traditional Chinese medicinal preparation Eriobotrya japonica - Fritillaria usuriensis dropping pills for pulmonary diseases. BMC Complement Altern Med. 2016;16:4 pubmed publisher
    ..A. DC. (Pla) and guanosine from Pinellia ternata (Thunb.) Makino. (Pin)...
  20. Sakamoto K, Ogihara A, Mitsuboshi S, Maeda H, Matsumoto T, Isaka T, et al. A successful surgical repair of intraoperative pneumothorax and the diffuse dissection of visceral pleura during liver transplantation surgery via trans-diaphragmatic approach. Surg Case Rep. 2019;5:7 pubmed publisher
    ..widely expanded like a giant cyst due to the dissection from the lung parenchyma and (2) a large air leakage from a pin hole appeared in the dissected pleura...
  21. Martínez Fernández R, Rodríguez Rojas R, del Alamo M, Hernández Fernández F, Pineda Pardo J, Dileone M, et al. Focused ultrasound subthalamotomy in patients with asymmetric Parkinson's disease: a pilot study. Lancet Neurol. 2018;17:54-63 pubmed publisher
    ..The most frequent adverse events were transient gait ataxia (related to subthalamotomy, six patients), transient pin-site head pain (related to the head frame, six patients), and transient high blood pressure (during the procedure, ..
  22. Tse A, Li J, Chan T, Wu R, Lai K. Hypoxia induces miR-210, leading to anti-apoptosis in ovarian follicular cells of marine medaka Oryzias melastigma. Aquat Toxicol. 2015;165:189-96 pubmed publisher
    ..A number of miR-210 target apoptotic genes, including Deleted in liver cancer 1 protein (DLC1), STE20-like serine/threonine-protein kinase (SLK), tumor necrosis factor receptor superfamily member 10b (..
  23. Kumar S, Lakshmi P, Sahi C, Pawar R. Sida cordifolia accelerates wound healing process delayed by dexamethasone in rats: Effect on ROS and probable mechanism of action. J Ethnopharmacol. 2019;235:279-292 pubmed publisher
    ..wound healing study, the period for complete re-epithelialization of the wound tissue was reduced significantly (pin the treatment groups as compared to the negative control group...
  24. Yan L, Zhang H, Gao S, Zhu G, Zhu Q, Gu Y, et al. EPO Derivative ARA290 Attenuates Early Renal Allograft Injury in Rats by Targeting NF-κB Pathway. Transplant Proc. 2018;50:1575-1582 pubmed publisher
    ..A rat model of renal allograft was established by anastomosis using a titanium ring pin stapler...
  25. El Magd M, Abdo W, El Maddaway M, Nasr N, Gaber R, El Shetry E, et al. High doses of S-methylcysteine cause hypoxia-induced cardiomyocyte apoptosis accompanied by engulfment of mitochondaria by nucleus. Biomed Pharmacother. 2017;94:589-597 pubmed publisher
    ..of apoptotic genes (caspase3 and Bax), hypoxia inducible factor 1 alpha (HIF1?), dynein light chain 1 (DYNLL1) and downregulation of the anti-apoptotic marker, Bcl2...
  26. Zhu M, Ding J, Jiang H, Kong L, Sun Z, Chen J, et al. Propofol ameliorates endothelial inflammation induced by hypoxia/reoxygenation in human umbilical vein endothelial cells: Role of phosphatase A2. Vascul Pharmacol. 2015;73:149-57 pubmed publisher
    ..Compared with the control group, H/R up-regulated expression of Pin-1 and PP2A, increased p66(Shc)-Ser(36) phosphorylation, induced p66(Shc) mitochondrial translocation, O2(-) ..
  27. Chernyavsky A, Shchepotin I, Grando S. Mechanisms of growth-promoting and tumor-protecting effects of epithelial nicotinic acetylcholine receptors. Int Immunopharmacol. 2015;29:36-44 pubmed publisher
    ..In this study, we sought to pin down principal mechanisms mediating the tumor-promoting activities of nicotine resulting from activation of cm- and ..
  28. Yang X, Zhou X, Tone P, Durkin M, Popescu N. Cooperative antiproliferative effect of coordinated ectopic expression of DLC1 tumor suppressor protein and silencing of MYC oncogene expression in liver cancer cells: Therapeutic implications. Oncol Lett. 2016;12:1591-1596 pubmed
    ..effect of combined knockdown of c-Myc expression and ectopic restoration of deleted in liver cancer 1 (DLC1) expression was investigated in human liver cancer cells...
  29. Zhou W, Zhang Y, Li Y, Wang S, Zhang J, Zhang C, et al. Investigating dysregulated pathways in Staphylococcus aureus (SA) exposed macrophages based on pathway interaction network. Comput Biol Chem. 2017;66:21-25 pubmed publisher
    ..dysregulated pathways for Staphylococcus aureus (SA) exposed macrophages based on pathway interaction network (PIN)...
  30. Shahid M, Subhan F, Ahmad N, Ullah I. A bacosides containing Bacopa monnieri extract alleviates allodynia and hyperalgesia in the chronic constriction injury model of neuropathic pain in rats. BMC Complement Altern Med. 2017;17:293 pubmed publisher
    ..paw withdrawal duration [PWD] to acetone), heat- (PWL to heat-stimulus) and punctate-hyperalgesia (PWD to pin-prick) were assessed on days 3, 7, 14 and 21...
  31. Meijer R, Halm J, Schepers T. Unstable fragility fractures of the ankle in the elderly: Transarticular Steinmann pin or external fixation. Foot (Edinb). 2017;32:35-38 pubmed publisher
    ..the results of two temporary fixation types in fragility fractures in the older patient: transarticular Steinmann pin fixation and external fixation...
  32. Gan Z, Wang Y, Wu T, Xu X, Zhang X, Han Z. MdPIN1b encodes a putative auxin efflux carrier and has different expression patterns in BC and M9 apple rootstocks. Plant Mol Biol. 2018;96:353-365 pubmed publisher
    ..As IAA polar transportation largely depends on the PIN-FORMED (PIN) auxin efflux carrier...
  33. Xie X, Qin G, Si P, Luo Z, Gao J, Chen X, et al. Analysis of Nicotiana tabacum PIN genes identifies NtPIN4 as a key regulator of axillary bud growth. Physiol Plant. 2017;160:222-239 pubmed publisher
    The plant-specific PIN-FORMED (PIN) auxin efflux proteins have been well characterized in many plant species, where they are crucial in the regulation of auxin transport in various aspects of plant development...
  34. Ma J, Wang T, Lovric V, Johnson K, Walsh W. A biomechanical comparison of Kirschner-wire fixation on fracture stability in Salter-Harris type I fractures of the proximal humeral physis in a porcine cadaveric model. BMC Vet Res. 2017;13:306 pubmed publisher
    ..001). The difference between three pins and two pins on toggle was not significant (p = 0.053), but both three-pin and two-pin fixation significantly reduced rotational toggle compared to one-pin fixation...
  35. Liu J, Lyu Q, Wang Q, Yu X. A digital memories based user authentication scheme with privacy preservation. PLoS ONE. 2017;12:e0186925 pubmed publisher
    The traditional username/password or PIN based authentication scheme, which still remains the most popular form of authentication, has been proved insecure, unmemorable and vulnerable to guessing, dictionary attack, key-logger, shoulder-..
  36. Li C, Wang N, Bi D. [Clinical observation of minor external fixation combined with Kirschner wire for open comminuted fracture of metacarpophalangeal joint]. Zhongguo Gu Shang. 2016;29:1110-1113 pubmed publisher
    ..6±1.0) weeks. No broken and loose needle, pin track infections, malunion, loose bracket, reflection sexual sense of neurological malnutrition occurred...
  37. Simásková M, O Brien J, Khan M, van Noorden G, Otvös K, Vieten A, et al. Cytokinin response factors regulate PIN-FORMED auxin transporters. Nat Commun. 2015;6:8717 pubmed publisher
    ..FACTORS (CRFs), transcription factors downstream of cytokinin perception, transcriptionally control genes encoding PIN-FORMED (PIN) auxin transporters at a specific PIN CYTOKININ RESPONSE ELEMENT (PCRE) domain...
  38. Cucinotta M, Manrique S, Guazzotti A, Quadrelli N, Mendes M, Benkova E, et al. Cytokinin response factors integrate auxin and cytokinin pathways for female reproductive organ development. Development. 2016;143:4419-4424 pubmed
    ..Crosstalk between these factors converges on regulation of the auxin carrier PIN-FORMED 1 (PIN1)...
  39. Rakusová H, Abbas M, Han H, Song S, Robert H, Friml J. Termination of Shoot Gravitropic Responses by Auxin Feedback on PIN3 Polarity. Curr Biol. 2016;26:3026-3032 pubmed publisher
    ..2] that is generated by lateral transport, mediated in the hypocotyl predominantly by the auxin transporter PIN-FORMED3 (PIN3) [3-5]...
  40. Zhu C, Chen P, Zhu R, Jiang G, Lin Z, Wu W, et al. Conversion of Triple Bonds into Single Bonds in a Domino Carbopalladation with Norbornene. Chem Asian J. 2017;: pubmed publisher
    ..formed ?-allylpalladium species are independently trapped by N-tosylhydrazones, boronic acids, and B2 pin2 in a highly diastereoselective manner, delivering the corresponding polycyclic and twisted products ..
  41. Lam H, Ho S, Chen J, Medvedovic M, Tam N. Bisphenol A Disrupts HNF4α-Regulated Gene Networks Linking to Prostate Preneoplasia and Immune Disruption in Noble Rats. Endocrinology. 2016;157:207-19 pubmed publisher
    ..1 ± 0.05 ng/mL). Prostatic hyperplasia, low-grade prostatic intraepithelial neoplasia (PIN), and marked infiltration of CD4+ and CD8+ T cells into the PIN epithelium (P < ...
  42. Lo Vecchio S, Petersen L, Finocchietti S, Gazerani P, Christensen S, Arendt Nielsen L, et al. Interaction between ultraviolet B-induced cutaneous hyperalgesia and nerve growth factor-induced muscle hyperalgesia. Eur J Pain. 2016;20:1058-69 pubmed publisher
    ..Cutaneous blood flow, pin-prick thresholds, pressure pain thresholds (PPTs), temporal summation to repetitive painful pressure stimulation, ..
  43. Lopes A, Andrade A, Silva I, Paiva W, Brock R, Teixeira M. Brain Abscess After Halo Fixation for the Cervical Spine. World Neurosurg. 2017;104:1047.e7-1047.e11 pubmed publisher
    ..However, improper use of these devices may lead to many complications, such as pin loosening, halo dislocation, pin site infection, and intradural penetration...
  44. Mravec J, Skupa P, Bailly A, Hoyerova K, Krecek P, Bielach A, et al. Subcellular homeostasis of phytohormone auxin is mediated by the ER-localized PIN5 transporter. Nature. 2009;459:1136-40 pubmed publisher
    ..In particular, PIN auxin-efflux-carrier-mediated, directional transport between cells is crucial for generating auxin gradients...
  45. Reimann S, Ayubi M, McDonald F, Bourauel C. Experimental investigation of the fracture torque of orthodontic anchorage screws. J Orofac Orthop. 2016;77:272-80 pubmed publisher
    ..The torsional deflection of ten different orthodontic anchorage screws from different manufacturers [Ortho Easy Pin (Forestadent), Benefit, quattro (both PSM Medical Solutions), Vector TAS (Ormco), AbsoAnchor(®) (DENTOS Inc...
  46. Saldanha I, Schmid C, Lau J, Dickersin K, Berlin J, Jap J, et al. Evaluating Data Abstraction Assistant, a novel software application for data abstraction during systematic reviews: protocol for a randomized controlled trial. Syst Rev. 2016;5:196 pubmed
    ..PDFs juxtaposed to electronic data abstraction forms linked to a data abstraction system, (2) highlight (or "pin") the location of the text in the PDF, and (3) copy relevant text from the PDF into the form...
  47. Corona P, Ramirez Nuñez L, Amat C, Carrera L. Outcome of oscillating saw open osteotomy in two-stage lower extremity bone transport with monolateral frame. Injury. 2017;48:2285-2291 pubmed publisher
    ..Finally, the Bone Healing Index (BHI) in our series averaged 21.09?days per cm. The main complication observed was pin-track infection, occurring in 45% of the cases...
  48. Osseman Q, Gallucci L, Au S, Cazenave C, Berdance E, Blondot M, et al. The chaperone dynein LL1 mediates cytoplasmic transport of empty and mature hepatitis B virus capsids. J Hepatol. 2018;68:441-448 pubmed publisher
    ..hepatocytes with cytoplasmic capsids are better recognized by the T cells, we hypothesize that targeting capsid DynLL1-interaction will not only block HBV infection but also stimulate elimination of infected cells...
  49. Lal Sahu R. Percutaneous K wire fixation in pediatric lateral condylar fractures of humerus: A prospective study. Rev Esp Cir Ortop Traumatol. 2018;62:1-7 pubmed publisher
    ..None of the patients had instability postoperatively. Post-operatively, 5.88% children got pin tract infection, which was superficial and healed after removing pins and oral antibiotic administration...
  50. Wang L, Guo X, Wang J, Jiang C, Bosland M, Lü J, et al. Methylseleninic Acid Superactivates p53-Senescence Cancer Progression Barrier in Prostate Lesions of Pten-Knockout Mouse. Cancer Prev Res (Phila). 2016;9:35-42 pubmed publisher
    ..human prostate cancer arises from precancerous lesions such as high-grade prostatic intraepithelial neoplasia (HG-PIN), which frequently have lost phosphatase and tensin homolog (PTEN) tumor suppressor permitting phosphatidylinositol-..
  51. Lopes O, de Freitas Spinelli L, Leite L, Buzzeto B, Saggin P, Kuhn A. Femoral tunnel enlargement after anterior cruciate ligament reconstruction using RigidFix compared with extracortical fixation. Knee Surg Sports Traumatol Arthrosc. 2017;25:1591-1597 pubmed publisher
    ..The present study showed greater enlargement of the femoral bone tunnel when a bioabsorbable trans-tunnel pin system was used with the medial portal technique when compared to extracortical fixation...
  52. Oelsner K, Guo Y, To S, Non A, Barkin S. Maternal BMI as a predictor of methylation of obesity-related genes in saliva samples from preschool-age Hispanic children at-risk for obesity. BMC Genomics. 2017;18:57 pubmed publisher
    ..Furthermore, eight of the 17 CpG sites reside in genes (FSTL1, SORCS2, NRF1, DLC1, PPARGC1B, CHN2, NXPH1) that have prior known associations with obesity, diabetes, and the insulin pathway...
  53. Soong M, Chase S, George Kasparyan N. Metacarpal fractures in the athlete. Curr Rev Musculoskelet Med. 2017;10:23-27 pubmed publisher
    ..be customized to the specific athlete and injury, and is often successful without surgery, or with percutaneous pin fixation...
  54. Visweswaraiah J, PITTMAN Y, Dever T, Hinnebusch A. The β-hairpin of 40S exit channel protein Rps5/uS7 promotes efficient and accurate translation initiation in vivo. elife. 2015;4:e07939 pubmed publisher
    ..Consistently, the β-strand-1 substitution greatly destabilized the 'PIN' conformation of TC binding to reconstituted 43S·mRNA complexes in vitro...
  55. Gibert S, Kowaleski M, Matthys R, Nützi R, Serck B, Boudrieau R. Biomechanical comparison of pin and tension-band wire fixation with a prototype locking plate fixation in a transverse canine patellar fracture model. Vet Comp Orthop Traumatol. 2016;29:20-8 pubmed publisher
    To compare a locking plate (LP) with pin and tension-band wire (pin/TBW) for fixation of mid-patellar transverse fractures. Cadaveric canine stifle joints from 10 adult mixed breed dogs (23-36 kg) were used...
  56. Solomin L, Andrianov M, Takata M, Tsuchiya H. Reference positions for transosseous elements in femur: A cadaveric study. Injury. 2016;47:1196-201 pubmed publisher
    During external fixator treatment, displacement of soft tissue at pin sites may cause infection and contracture. Due to surrounding soft tissue thickness, the femur is especially susceptible to severe complications...
  57. Schakenraad K, Biebricher A, Sebregts M, Ten Bensel B, Peterman E, Wuite G, et al. Hyperstretching DNA. Nat Commun. 2017;8:2197 pubmed publisher
    ..These results pin down the physical principles that govern DNA mechanics under the influence of tension and biochemical reactions...
  58. Chen J, Wang F, Zheng S, Xu T, Yang Z. Pavement cells: a model system for non-transcriptional auxin signalling and crosstalks. J Exp Bot. 2015;66:4957-70 pubmed publisher
    ..Rho GTPases from plants and subsequent downstream events regulating cytoskeletal reorganization and PIN polarization...
  59. Dworsky E, Hegde V, Loftin A, Richman S, Hu Y, Lord E, et al. Novel in vivo mouse model of implant related spine infection. J Orthop Res. 2017;35:193-199 pubmed publisher
    ..Bacteria were then harvested from the pin and surrounding tissue for confirmatory CFU counts...
  60. Farhoudi H, Fallahnezhad K, Oskouei R, Taylor M. A finite element study on the mechanical response of the head-neck interface of hip implants under realistic forces and moments of daily activities: Part 1, level walking. J Mech Behav Biomed Mater. 2017;75:470-476 pubmed publisher
    ..These ranges were found comparable to previous experimental displacement-controlled pin/cylinder-on-disk fretting corrosion studies.
  61. Cotogno G, Holzwarth U, Franchi M, Rivetti S, Chiesa R. Tribological characterization of surface-treated commercially pure titanium for femoral heads in total hip replacement: a feasibility study. Int J Artif Organs. 2006;29:1174-84 pubmed
    ..The tribological properties were characterized by multidirectional pin-on-flat screening wear tests, using UHMWPE pins as bearing surface...
  62. Parhad S, Jaiswal D, Ray K, Mazumdar S. The protein inhibitor of nNOS (PIN/DLC1/LC8) binding does not inhibit the NADPH-dependent heme reduction in nNOS, a key step in NO synthesis. Biochem Biophys Res Commun. 2016;472:189-93 pubmed publisher
    ..Although previous studies have indicated that the dynein light chain 1 (DLC1) binding to nNOS could inhibit the NO synthesis, the claim is challenged by contradicting reports...
  63. Losko M, Lichawska Cieslar A, Kulecka M, Paziewska A, Rumienczyk I, Mikula M, et al. Ectopic overexpression of MCPIP1 impairs adipogenesis by modulating microRNAs. Biochim Biophys Acta Mol Cell Res. 2018;1865:186-195 pubmed publisher
    ..protein-1-induced protein 1 (MCPIP1) possesses the N-terminus of the PilT protein (PilT N-terminus or PIN domain) that has RNase properties...
  64. Khan K, Aslam M, Zahra F, Basheer H, Bilal M, Sumrin A. Potential biomarkers for the diagnosis of respiratory tract infection and lungs cancer. Cell Mol Biol (Noisy-le-grand). 2017;63:46-52 pubmed publisher
    ..shown great potential in specific diagnosis of many respiratory diseases and also have shown capability in timely pin pointing different stages of lung carcinomas...
  65. Liu X, McKenzie J, Maschhoff C, Gardner M, Silva M. Exogenous hedgehog antagonist delays but does not prevent fracture healing in young mice. Bone. 2017;103:241-251 pubmed publisher
    ..We created closed, transverse diaphyseal femur fractures in mice, stabilized with an intramedullary pin, and administered a systemic Hh inhibitor or vehicle...
  66. Erdös G, Szaniszlo T, Pajkos M, Hajdu Soltész B, Kiss B, Pal G, et al. Novel linear motif filtering protocol reveals the role of the LC8 dynein light chain in the Hippo pathway. PLoS Comput Biol. 2017;13:e1005885 pubmed publisher
    ..The approach was applied to the dynein light chain LC8, a ubiquitous eukaryotic hub protein that has been suggested to be involved in motor-related functions as well as ..
  67. Critchley A, Holtham S. An unusual case of chronic anal pain--a pin in the bum?. Ann R Coll Surg Engl. 2010;92:W27-8 pubmed publisher
    ..This was removed and she has been subsequently asymptomatic. This condition was clearly difficult to diagnose and requires a high index of suspicion in those patients who have previously undergone pelvic surgery...
  68. Merrimen J, Evans A, Srigley J. Preneoplasia in the prostate gland with emphasis on high grade prostatic intraepithelial neoplasia. Pathology. 2013;45:251-63 pubmed publisher
    ..Prostatic intraepithelial neoplasia (PIN), inflammation with or without atrophy, and adenosis (atypical adenomatous hyperplasia) have all been given ..
  69. Tian Y, Liu Z, Xiao H, Zhao G, Liu G, Yang J, et al. Experimental demonstration of a reconfigurable electro-optic directed logic circuit using cascaded carrier-injection micro-ring resonators. Sci Rep. 2017;7:6410 pubmed publisher
    ..b>PIN diodes embedded around MRRs are employed to achieve the carrier injection modulation...
  70. D Urso G, Giardini C. Thermo-Mechanical Characterization of Friction Stir Spot Welded AA7050 Sheets by Means of Experimental and FEM Analyses. Materials (Basel). 2016;9: pubmed publisher
    ..A specific external routine for the calculation of the thermal energy due to friction acting between pin and sheet was developed...
  71. Juneja R, Nambiar P. Cardiomyopathies and anaesthesia. Indian J Anaesth. 2017;61:728-735 pubmed publisher
    ..With more and more research and with the advent of genetic analysis pin pointing the disease causing mutations, causative factors have been defined and classifications and definitions ..
  72. Walsh E, Feuerborn A, Wheeler J, Tan A, Durham W, Foster K, et al. Microfluidics with fluid walls. Nat Commun. 2017;8:816 pubmed publisher
    ..circuits with any 2D shape are printed in seconds on plastic or glass Petri dishes; then, interfacial forces pin liquids to substrates, and overlaying an immiscible liquid prevents evaporation...
  73. Lee E, Yang H, Cho J, Ko J, Moon J. Two Cases of Colonoscopic Retrieval of a Foreign Body in Children: A Button Battery and an Open Safety Pin. Pediatr Gastroenterol Hepatol Nutr. 2017;20:204-209 pubmed publisher
    ..We report one case of a button battery and one case of an open safety pin, both impacted in the terminal ileum that had moved from the stomach within a few hours of ingestion and were ..
  74. Sobol G, Gibson P, Patel P, Koury K, Sirkin M, Reilly M, et al. Low Incidence of Neurovascular Complications After Placement of Proximal Tibial Traction Pins. Orthopedics. 2017;40:e1004-e1008 pubmed publisher
    ..The medical record was reviewed to determine whether a pin-related complication had occurred...
  75. Ruzicka K, Strader L, Bailly A, Yang H, Blakeslee J, Langowski L, et al. Arabidopsis PIS1 encodes the ABCG37 transporter of auxinic compounds including the auxin precursor indole-3-butyric acid. Proc Natl Acad Sci U S A. 2010;107:10749-53 pubmed publisher
    ..homolog ABCG36 act redundantly at outermost root plasma membranes and, unlike established IAA transporters from the PIN and ABCB families, transport IBA out of the cells...
  76. Liu Y, Zhang P. Characterization of compression behaviors of fully covered biodegradable polydioxanone biliary stent for human body: A numerical approach by finite element model. J Mech Behav Biomed Mater. 2016;62:128-138 pubmed publisher
    ..investigate the relationship between the compression force and structure parameter (monofilament diameter and braid-pin number), nine numerical models based on actual biliary stent were established, the simulation and experimental ..
  77. Liao X, Qiu Z, Jiang T, Sadiq M, Huang Z, Demore C, et al. Functional Piezocrystal Characterisation under Varying Conditions. Materials (Basel). 2015;8:8304-8326 pubmed publisher
    ..Three generations of piezocrystal have been tested: (I) binary, PMN-PT; (II) ternary, PIN-PMN-PT; and (III) doped ternary, Mn:PIN-PMN-PT...
  78. Mohan P, Hosur R. pH dependent unfolding characteristics of DLC8 dimer: Residue level details from NMR. Biochim Biophys Acta. 2008;1784:1795-803 pubmed publisher
    ..In the present study we investigated the guanidine induced unfolding transition of dynein light chain protein (DLC8), a cargo adaptor of the dynein complex in the pH range 7-10...
  79. Beaulac J, Edwards J, Steele A. Formative evaluation of practice changes for managing depression within a Shared Care model in primary care. Prim Health Care Res Dev. 2017;18:50-63 pubmed
    Aim To investigate the implementation and initial impact of the Physician Integrated Network (PIN) mental health indicators, which are specific to screening and managing follow-up for depression, in three primary care practices with ..
  80. Melendez P, Romero C, Pithua P, Marin M, Pinedo P, Duchens M. Retrospective evaluation of milk production and culling risk following either surgical, toggle-pin suture or conservative treatment of left displaced abomasum in Chilean dairy cows. N Z Vet J. 2017;65:292-296 pubmed publisher
    ..However, the retrospective nature of the data, the inclusion of only four herds and the non-random allocation to treatments means that these conclusions cannot be extrapolated to the overall dairy cattle population in Chile...
  81. Nieto A, Jiang L, Kim J, Kim D, Schoenung J. Synthesis and Multi Scale Tribological Behavior of WC-Co/Nanodiamond Nanocomposites. Sci Rep. 2017;7:7060 pubmed publisher
    ..Macroscale reciprocating pin-on-disk tests were conducted to assess wear behavior under conditions relevant to service environments, e.g...
  82. Egevad L, Delahunt B, Kristiansen G, Samaratunga H, Varma M. Contemporary prognostic indicators for prostate cancer incorporating International Society of Urological Pathology recommendations. Pathology. 2018;50:60-73 pubmed publisher
    ..propose that atypical intraductal proliferation, indeterminate for high-grade prostatic intraepithelial neoplasia (PIN) and IDCP, should be reported as atypical proliferation suspicious for IDCP (ASID) with a note that the lesion is ..
  83. Ye Y, Li S, Ma Y, Diao Y, Yang L, Su M, et al. Exosomal miR-141-3p regulates osteoblast activity to promote the osteoblastic metastasis of prostate cancer. Oncotarget. 2017;8:94834-94849 pubmed publisher
    ..miR-141-3p suppressed the protein levels of the target gene DLC1, indicating its functional significance in activating the p38MAPK pathway...
  84. Pfister K, Fisher E, Gibbons I, Hays T, Holzbaur E, McIntosh J, et al. Cytoplasmic dynein nomenclature. J Cell Biol. 2005;171:411-3 pubmed
    ..This nomenclature recognizes the two distinct cytoplasmic dynein complexes and has the flexibility to accommodate the discovery of new subunits and isoforms. ..
  85. Peng W, Li M, Chen L, Wang L. Predicting Protein Functions by Using Unbalanced Random Walk Algorithm on Three Biological Networks. IEEE/ACM Trans Comput Biol Bioinform. 2017;14:360-369 pubmed publisher
    ..which takes several steps of random walking on three different biological networks: protein interaction network (PIN), domain co-occurrence network (DCN), and functional interrelationship network (FIN), respectively, so as to infer ..
  86. Martínez Muñoz A, Bello M, Romero Castro A, Rodríguez Fonseca R, Rodrigues J, Sánchez Espinosa V, et al. Binding free energy calculations using MMPB/GBSA approaches for PAMAM-G4-drug complexes at neutral, basic and acid pH conditions. J Mol Graph Model. 2017;76:330-341 pubmed publisher
    ..area and for ventricular tachycardia treatment, Metoprolol (MET) - a β1 receptor blocker, and Pindolol (PIN) - a β blocker, which have the lowest affinities for the G4-PAMAM dendrimer, to perform MD simulations combined ..
  87. Kim H, Hyeon S, Kim H, Yang Y, Huh J, Park D, et al. Dynein light chain LC8 inhibits osteoclast differentiation and prevents bone loss in mice. J Immunol. 2013;190:1312-8 pubmed publisher
    ..The 8-kDa dynein L chain (LC8) was previously identified as a novel NF-?B regulator...
  88. de Thomasson E, Gouzy S, Cloerec F, Geais L. Is determination of the hip rotation center during computer-assisted surgery influenced by the pinless femoral sensor attachment method? An in vitro preliminary study comparing osseous pin fixation. Orthop Traumatol Surg Res. 2016;102:375-8 pubmed publisher
    ..7%) close to that obtained with a pin (6%)...
  89. Smithard J, Rajic N, van der Velden S, Norman P, Rosalie C, Galea S, et al. An Advanced Multi-Sensor Acousto-Ultrasonic Structural Health Monitoring System: Development and Aerospace Demonstration. Materials (Basel). 2017;10: pubmed publisher
    ..on four Piezoelectric Wafer Active Sensor (PWAS) elements with further sensing on four Positive Intrinsic Negative (PIN) photodiodes for intensity-based interrogation of Fiber Bragg Gratings (FBG)...
  90. Azeza B, Hadj Alouane M, Ilahi B, Patriarche G, Sfaxi L, Fouzri A, et al. Towards InAs/InGaAs/GaAs Quantum Dot Solar Cells Directly Grown on Si Substrate. Materials (Basel). 2015;8:4544-4552 pubmed publisher
    ..The effect of inserting 40 InAs/InGaAs/GaAs QDs layers in the intrinsic region of the heterojunction pin-GaAs/n?-Si was evaluated using photocurrent spectroscopy in comparison with pin-GaAs/n?-Si and pin-GaAs/GaAs ..
  91. Kim M, Koh I, Choi Y, In Y. Posterior Cruciate Ligament Reconstruction with Retrograde Femoral Technique, Posterior Trans-septal Portal and Full Tibial Tunnel. Arthrosc Tech. 2017;6:e973-e978 pubmed publisher
    ..A retrograde drilling pin that recently has been popular in ACL reconstruction allows "no incision" in the outside-in (OI) technique for the ..
  92. Morris K, Law E, Jefferys R, Dearth E, Fabyanic E. An evaluation of the discriminating power of an Integrated Ballistics Identification System® Heritage™system with the NIST standard cartridge case (Standard Reference Material 2461). Forensic Sci Int. 2017;280:188-193 pubmed publisher
    Through analysis and comparison of firing pin, breech face, and ejector impressions, where appropriate, firearm examiners may connect a cartridge case to a suspect firearm with a certain likelihood in a criminal investigation...