DYNC1LI1

Summary

Gene Symbol: DYNC1LI1
Description: dynein cytoplasmic 1 light intermediate chain 1
Alias: DLC-A, DNCLI1, LIC1, cytoplasmic dynein 1 light intermediate chain 1, dynein light chain A, dynein light intermediate chain 1, cytosolic, dynein, cytoplasmic, light intermediate polypeptide 1
Species: human
Products:     DYNC1LI1

Top Publications

  1. Bielli A, Thörnqvist P, Hendrick A, Finn R, Fitzgerald K, McCaffrey M. The small GTPase Rab4A interacts with the central region of cytoplasmic dynein light intermediate chain-1. Biochem Biophys Res Commun. 2001;281:1141-53 pubmed
    ..Additionally, GFPRab4A endosomes localize to microtubules and are redistributed by nocodazole treatment. This is the first described interaction between cytoplasmic dynein, a retrograde motor protein, and a Rab protein. ..
  2. Tynan S, Purohit A, Doxsey S, Vallee R. Light intermediate chain 1 defines a functional subfraction of cytoplasmic dynein which binds to pericentrin. J Biol Chem. 2000;275:32763-8 pubmed
    ..Here we report the cloning of rat LIC1, which is approximately 75% homologous to rat LIC2 and also contains a P-loop consensus sequence...
  3. Horgan C, Hanscom S, Jolly R, Futter C, McCaffrey M. Rab11-FIP3 links the Rab11 GTPase and cytoplasmic dynein to mediate transport to the endosomal-recycling compartment. J Cell Sci. 2010;123:181-91 pubmed publisher
    ..Rab11-FIP3 (henceforth, FIP3) directly interacts with the dynein light intermediate chain 1 (DLIC-1, gene symbol DYNC1LI1) subunit of the cytoplasmic dynein 1 motor protein complex...
  4. Tan S, Scherer J, Vallee R. Recruitment of dynein to late endosomes and lysosomes through light intermediate chains. Mol Biol Cell. 2011;22:467-77 pubmed publisher
    ..The dynein light intermediate chains, LIC1 and LIC2 (DYNC1LI1 and DYNC1LI2, respectively), have been implicated in cargo binding, but their full range of functions is unknown...
  5. Splinter D, Razafsky D, Schlager M, Serra Marques A, Grigoriev I, Demmers J, et al. BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures. Mol Biol Cell. 2012;23:4226-41 pubmed publisher
    ..Our results demonstrate that dynein recruitment to cargo requires concerted action of multiple dynein cofactors...
  6. Sivaram M, Wadzinski T, Redick S, Manna T, Doxsey S. Dynein light intermediate chain 1 is required for progress through the spindle assembly checkpoint. EMBO J. 2009;28:902-14 pubmed publisher
    ..Here we show that human cells depleted of dynein light intermediate chain 1 (LIC1) delay in metaphase with increased interkinetochore distances; dynein remains intact, localised and functional...
  7. Schroeder C, Ostrem J, Hertz N, Vale R. A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region. elife. 2014;3:e03351 pubmed publisher
    ..Despite having a G protein fold, the fungal LIC has lost its ability to bind nucleotide, while the human LIC1 binds GDP preferentially over GTP...
  8. Schroeder C, Vale R. Assembly and activation of dynein-dynactin by the cargo adaptor protein Hook3. J Cell Biol. 2016;214:309-18 pubmed publisher
    ..We show that the conserved Hook domain interacts directly with the dynein light intermediate chain 1 (LIC1)...
  9. Pfister K, Fisher E, Gibbons I, Hays T, Holzbaur E, McIntosh J, et al. Cytoplasmic dynein nomenclature. J Cell Biol. 2005;171:411-3 pubmed
    ..This nomenclature recognizes the two distinct cytoplasmic dynein complexes and has the flexibility to accommodate the discovery of new subunits and isoforms. ..

More Information

Publications13

  1. Horgan C, Hanscom S, McCaffrey M. Dynein LIC1 localizes to the mitotic spindle and midbody and LIC2 localizes to spindle poles during cell division. Cell Biol Int. 2011;35:171-8 pubmed publisher
    ..The dynein LIC (light intermediate chain) subunits, LIC1 (DLIC-1, gene symbol DYNC1LI1) and LIC2 (DLIC-2, gene symbol DYNC1LI2), associate with the dynein HC (heavy chain) in a mutually exclusive ..
  2. Lukic Z, Dharan A, Fricke T, Diaz Griffero F, Campbell E. HIV-1 uncoating is facilitated by dynein and kinesin 1. J Virol. 2014;88:13613-25 pubmed publisher
    ..Targeting these factors may either directly inhibit infection or delay it enough to trigger mediators of intrinsic immunity that recognize cytoplasmic capsid or DNA and subsequently induce an antiviral state in these cells. ..
  3. Jones L, Villemant C, Starborg T, Salter A, Goddard G, Ruane P, et al. Dynein light intermediate chains maintain spindle bipolarity by functioning in centriole cohesion. J Cell Biol. 2014;207:499-516 pubmed publisher
    ..The role of the light intermediate chains (LICs; DYNC1LI1 and 2) within the complex is poorly understood...
  4. Liu Z, Zhang S, Hao J, Xie T, Kang J. Cellular model of neuronal atrophy induced by DYNC1I1 deficiency reveals protective roles of RAS-RAF-MEK signaling. Protein Cell. 2016;7:638-50 pubmed publisher
    ..These findings demonstrate protective roles of the RAS-RAF-MEK axis against neuronal atrophy, and imply a new therapeutic target for clinical intervention. ..