Genomes and Genes
Gene Symbol: DYNC1LI1
Description: dynein cytoplasmic 1 light intermediate chain 1
Alias: DLC-A, DNCLI1, LIC1, cytoplasmic dynein 1 light intermediate chain 1, dynein light chain A, dynein light intermediate chain 1, cytosolic, dynein, cytoplasmic, light intermediate polypeptide 1
- Horgan C, Hanscom S, McCaffrey M. Dynein LIC1 localizes to the mitotic spindle and midbody and LIC2 localizes to spindle poles during cell division. Cell Biol Int. 2011;35:171-8 pubmed publisher..The dynein LIC (light intermediate chain) subunits, LIC1 (DLIC-1, gene symbol DYNC1LI1) and LIC2 (DLIC-2, gene symbol DYNC1LI2), associate with the dynein HC (heavy chain) in a mutually exclusive ..
- Lukic Z, Dharan A, Fricke T, Diaz Griffero F, Campbell E. HIV-1 uncoating is facilitated by dynein and kinesin 1. J Virol. 2014;88:13613-25 pubmed publisher..Targeting these factors may either directly inhibit infection or delay it enough to trigger mediators of intrinsic immunity that recognize cytoplasmic capsid or DNA and subsequently induce an antiviral state in these cells. ..
- Jones L, Villemant C, Starborg T, Salter A, Goddard G, Ruane P, et al. Dynein light intermediate chains maintain spindle bipolarity by functioning in centriole cohesion. J Cell Biol. 2014;207:499-516 pubmed publisher..The role of the light intermediate chains (LICs; DYNC1LI1 and 2) within the complex is poorly understood...
- Liu Z, Zhang S, Hao J, Xie T, Kang J. Cellular model of neuronal atrophy induced by DYNC1I1 deficiency reveals protective roles of RAS-RAF-MEK signaling. Protein Cell. 2016;7:638-50 pubmed publisher..These findings demonstrate protective roles of the RAS-RAF-MEK axis against neuronal atrophy, and imply a new therapeutic target for clinical intervention. ..