Gene Symbol: DYNC1H1
Description: dynein cytoplasmic 1 heavy chain 1
Alias: CMT2O, DHC1, DHC1a, DNCH1, DNCL, DNECL, DYHC, Dnchc1, HL-3, SMALED1, p22, cytoplasmic dynein 1 heavy chain 1, dynein heavy chain, cytosolic, dynein, cytoplasmic, heavy polypeptide 1
Species: human
Products:     DYNC1H1

Top Publications

  1. Sasaki S, Shionoya A, Ishida M, Gambello M, Yingling J, Wynshaw Boris A, et al. A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system. Neuron. 2000;28:681-96 pubmed
    ..These results suggest that LIS1 and NUDEL regulate CDHC activity during neuronal migration and axonal retrograde transport in a Cdk5/p35-dependent fashion. ..
  2. Tanenbaum M, Macurek L, Galjart N, Medema R. Dynein, Lis1 and CLIP-170 counteract Eg5-dependent centrosome separation during bipolar spindle assembly. EMBO J. 2008;27:3235-45 pubmed publisher
    ..Taken together, these results suggest that complexes of dynein, Lis1 and CLIP-170 crosslink and slide microtubules within the spindle, thereby producing an inward force that pulls centrosomes together. ..
  3. Hoogenraad C, Akhmanova A, Howell S, Dortland B, De Zeeuw C, Willemsen R, et al. Mammalian Golgi-associated Bicaudal-D2 functions in the dynein-dynactin pathway by interacting with these complexes. EMBO J. 2001;20:4041-54 pubmed
    ..Taken together, these data suggest that mammalian BICD2 plays a role in the dynein- dynactin interaction on the surface of membranous organelles, by associating with these complexes. ..
  4. Tai C, Dujardin D, Faulkner N, Vallee R. Role of dynein, dynactin, and CLIP-170 interactions in LIS1 kinetochore function. J Cell Biol. 2002;156:959-68 pubmed
    ..Together, our data suggest a novel role for LIS1 in mediating CLIP-170-dynein interactions and in coordinating dynein cargo-binding and motor activities. ..
  5. Lehmann M, Milev M, Abrahamyan L, Yao X, Pante N, Mouland A. Intracellular transport of human immunodeficiency virus type 1 genomic RNA and viral production are dependent on dynein motor function and late endosome positioning. J Biol Chem. 2009;284:14572-85 pubmed publisher
    ..Our results demonstrate that dynein motor function is important for regulating Gag and vRNA egress on endosomal membranes in the cytoplasm to directly impact on viral production. ..
  6. Splinter D, Razafsky D, Schlager M, Serra Marques A, Grigoriev I, Demmers J, et al. BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures. Mol Biol Cell. 2012;23:4226-41 pubmed publisher
    ..Our results demonstrate that dynein recruitment to cargo requires concerted action of multiple dynein cofactors...
  7. Pawlica P, Le Sage V, Poccardi N, Tremblay M, Mouland A, Berthoux L. Functional evidence for the involvement of microtubules and dynein motor complexes in TRIM5?-mediated restriction of retroviruses. J Virol. 2014;88:5661-76 pubmed publisher
    ..In conclusion, association with microtubules and the translocation activity of dynein motor complexes are required to achieve efficient restriction by TRIM5?...
  8. Vaisberg E, Koonce M, McIntosh J. Cytoplasmic dynein plays a role in mammalian mitotic spindle formation. J Cell Biol. 1993;123:849-58 pubmed
    ..Possible mechanisms of dynein's involvement in mitosis are discussed. ..
  9. Habermann A, Schroer T, Griffiths G, Burkhardt J. Immunolocalization of cytoplasmic dynein and dynactin subunits in cultured macrophages: enrichment on early endocytic organelles. J Cell Sci. 2001;114:229-240 pubmed
    ..In contrast, our results show that dynactin can associate with microtubule ends in the absence of dynein, perhaps providing sites for subsequent organelle and dynein association to form a functional motility complex. ..

More Information

Publications115 found, 100 shown here

  1. Niethammer M, Smith D, Ayala R, Peng J, Ko J, Lee M, et al. NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein. Neuron. 2000;28:697-711 pubmed
    ..Inhibition of Cdk5 modifies NUDEL distribution in neurons and affects neuritic morphology. Our findings point to cross-talk between two prominent pathways that regulate neuronal migration. ..
  2. Yamada M, Toba S, Yoshida Y, Haratani K, Mori D, Yano Y, et al. LIS1 and NDEL1 coordinate the plus-end-directed transport of cytoplasmic dynein. EMBO J. 2008;27:2471-83 pubmed publisher
  3. Kotak S, Busso C, G nczy P. Cortical dynein is critical for proper spindle positioning in human cells. J Cell Biol. 2012;199:97-110 pubmed publisher
    ..Overall, we propose a model in which the ternary complex serves to anchor dynein at the plasma membrane to ensure correct spindle positioning...
  4. Raaijmakers J, Tanenbaum M, Medema R. Systematic dissection of dynein regulators in mitosis. J Cell Biol. 2013;201:201-15 pubmed publisher
  5. Maiolino G, Azzolini M, Rossi G, Davis P, Calò L. Bartter/Gitelman syndromes as a model to study systemic oxidative stress in humans. Free Radic Biol Med. 2015;88:51-8 pubmed publisher
    ..In fact, Bartter/Gitelman syndrome patients are characterized by reduced levels of p22(phox) gene expression and undetectable plasma peroxynitrite levels, while showing increased plasma antioxidant ..
  6. Song Q, Zhang Y, Han X, Zhang Y, Zhang X, Gao Y, et al. Potential mechanisms underlying the protective effects of salvianic acid A against atherosclerosis in vivo and vitro. Biomed Pharmacother. 2019;109:945-956 pubmed publisher
    ..factor erythroid 2-related factor 2/heme oxygenase-1 pathway and downregulated expression of p47phox and p22phox (all P <  0.05) in vivo...
  7. Hong S, Lee H, Sohn E, Ko H, Shim B, Ahn K, et al. Anti-nephrolithic potential of resveratrol via inhibition of ROS, MCP-1, hyaluronan and osteopontin in vitro and in vivo. Pharmacol Rep. 2013;65:970-9 pubmed
    ..the mRNA expression of nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) oxidase subunits such as p22(phox) and p47(phox), monocyte chemoattractant protein 1 (MCP-1) and osteopontin (OPN) in oxalate-treated HRCs...
  8. Zheng S, Zhong Z, Qin S, Chen G, Wu Q, Zeng J, et al. Advanced oxidation protein products induce inflammatory response in fibroblast-like synoviocytes through NADPH oxidase -dependent activation of NF-κB. Cell Physiol Biochem. 2013;32:972-85 pubmed publisher
    ..Challenged AOPPs induced phosphorylation of p47(phox), triggered an interaction between p47(phox), p22(phox) and gp91(phox), and significantly upregulated expression of NADPH oxidase subunits p47(phox), p22(phox) and ..
  9. Rincon J, Correia D, Arcaya J, Finol E, Fernandez A, Perez M, et al. Role of Angiotensin II type 1 receptor on renal NAD(P)H oxidase, oxidative stress and inflammation in nitric oxide inhibition induced-hypertension. Life Sci. 2015;124:81-90 pubmed publisher
    ..After two weeks, L-NAME induced high blood pressure, renal overexpression of AT1R, NAD(P)H oxidase sub-units gp91, p22 and p47, increased levels of oxidative stress, interleukin-6 (IL-6) and interleukin-17 (IL-17)...
  10. Agharazii M, St Louis R, Gautier Bastien A, Ung R, Mokas S, Larivière R, et al. Inflammatory cytokines and reactive oxygen species as mediators of chronic kidney disease-related vascular calcification. Am J Hypertens. 2015;28:746-55 pubmed publisher
    ..The expression of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunits p22(phox) and p47(phox) were increased, whereas the expression of antioxidant enzymes (SOD1, SOD2, Gpx1, and Prdx1) was ..
  11. Thandavarayan R, Giridharan V, Sari F, Arumugam S, Veeraveedu P, Pandian G, et al. Depletion of 14-3-3 protein exacerbates cardiac oxidative stress, inflammation and remodeling process via modulation of MAPK/NF-ĸB signaling pathways after streptozotocin-induced diabetes mellitus. Cell Physiol Biochem. 2011;28:911-22 pubmed publisher
    ..Moreover, reactive oxygen species, left ventricular expression of NADPH oxidase subunits, p22 phox, p67 phox, and Nox4, and lipid peroxidation levels were significantly increased in diabetic DN 14-3-3mice ..
  12. Zhang Y, Wei Z, Li J, Liu P. Molecular pathogenesis of lymphomas of mucosa-associated lymphoid tissue--from (auto)antigen driven selection to the activation of NF-κB signaling. Sci China Life Sci. 2015;58:1246-55 pubmed publisher
    ..been identified in MALT lymphoma, and among them are important translocations, such as t(11;18)(q21;q21), t(1;14)(p22;q32), t(14;18)(q32;q21) and t(3;14)(p13;q32)...
  13. Yiu W, Mead P, Jun H, Mansfield B, Chou J. Oxidative stress mediates nephropathy in type Ia glycogen storage disease. Lab Invest. 2010;90:620-9 pubmed publisher
    ..In this study, we further elucidate the mechanism of renal disease by showing that renal expression of Nox-2, p22(phox), and p47(phox), components of NADPH oxidase, are upregulated in GSD-Ia mice compared with controls...
  14. Dosoki H, Stegemann A, Taha M, Schnittler H, Luger T, Schröder K, et al. Targeting of NADPH oxidase in vitro and in vivo suppresses fibroblast activation and experimental skin fibrosis. Exp Dermatol. 2017;26:73-81 pubmed publisher
    ..expression analysis of all Nox isoforms and adaptors revealed expression of RNA and protein expression of Nox4, p22phox and Poldip2 but neither Nox1 nor Nox2. Nox4 could be immunolocalized to the endoplasmic reticulum...
  15. Martinez P, Bonomo C, Guizoni D, Junior S, Damatto R, Cezar M, et al. Influence of N- acetylcysteine on oxidative stress in slow-twitch soleus muscle of heart failure rats. Cell Physiol Biochem. 2015;35:148-59 pubmed publisher
    ..Gene expression of p47(phox) was lower in MI-C than Sham. NAC decreased NOX4 and p22(phox) expression...
  16. Araos P, Mondaca D, Jalil J, Yañez C, Novoa U, Mora I, et al. Diuretics prevent Rho-kinase activation and expression of profibrotic/oxidative genes in the hypertensive aortic wall. Ther Adv Cardiovasc Dis. 2016;10:338-347 pubmed
    ..growth factor ?1 (TGF-?1), gene expression of TGF-?1, connective tissue growth factor (CTGF), p22 phox and gp91 phox subunits of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, as well as increased ..
  17. Ding K, Wang Y, Jiang W, Zhang Y, Yin H, Fang Z. Qian Yang Yu Yin Granule-containing serum inhibits angiotensin II-induced proliferation, reactive oxygen species production, and inflammation in human mesangial cells via an NADPH oxidase 4-dependent pathway. BMC Complement Altern Med. 2015;15:81 pubmed publisher
    ..QYGS considerably suppressed production of ROS, decreased mRNA and protein expression of NAPDH-oxidase 4 (NOX4), p22 (phox) , and activated Ras-related C3 botulinum toxin substrate 1 (GTP-Rac1); as well as counteracted the up-..
  18. Banks G, Bros Facer V, Williams H, Chia R, Achilli F, Bryson J, et al. Mutant glycyl-tRNA synthetase (Gars) ameliorates SOD1(G93A) motor neuron degeneration phenotype but has little affect on Loa dynein heavy chain mutant mice. PLoS ONE. 2009;4:e6218 pubmed publisher
    ..other mutants: the TgSOD1(G93A) model of human amyotrophic lateral sclerosis and the Legs at odd angles mouse (Dync1h1(Loa)) which has a defect in the heavy chain of the dynein complex...
  19. Moloney J, Stanicka J, Cotter T. Subcellular localization of the FLT3-ITD oncogene plays a significant role in the production of NOX- and p22phox-derived reactive oxygen species in acute myeloid leukemia. Leuk Res. 2017;52:34-42 pubmed publisher
    ..A induce ER retention of FLT3-ITD, resulting in a decrease in protein expression of NOX4 and its partner protein p22phox, thus demonstrating the critical importance of FLT3-ITD localization for the generation of pro-..
  20. Song Q, Liu L, Yu J, Zhang J, Xu M, Sun L, et al. Dihydromyricetin attenuated Ang II induced cardiac fibroblasts proliferation related to inhibitory of oxidative stress. Eur J Pharmacol. 2017;807:159-167 pubmed publisher
    ..Expression of type I, type III collagen, ?-smooth muscle actin (?-SMA), p22phox (one vital subunit of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase), SOD and ..
  21. Jeong J, Koo J, Cho J, Kang E. Neuroprotective effect of treadmill exercise against blunted brain insulin signaling, NADPH oxidase, and Tau hyperphosphorylation in rats fed a high-fat diet. Brain Res Bull. 2018;142:374-383 pubmed publisher
    ..oxidase, and immunohistochemistry was performed to examine the immunoreactivity of p-Tau (Ser 202/Thr 205) and p22-phox...
  22. Park C, Lee J, Kim M, Shin S, Roh S, Choi J, et al. Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, protects the pancreas from apoptosis and proliferation via oxidative stress in streptozotocin-induced diabetic rats. Food Funct. 2016;7:3056-3063 pubmed publisher
    ..species (ROS) level, and western blots of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-4 (Nox-4), p22(phox), p47(phox), phosphor-c-Jun N-terminal kinase (p-JNK), Bax, cytochrome c, caspase 3, pancreatic-duodenal ..
  23. Cowley A, Yang C, Zheleznova N, Staruschenko A, Kurth T, Rein L, et al. Evidence of the Importance of Nox4 in Production of Hypertension in Dahl Salt-Sensitive Rats. Hypertension. 2016;67:440-50 pubmed publisher
    ..Before the development of hypertension, RNA expression levels of Nox subunits Nox2, p67(phox), and p22(phox) were found to be significantly lower (P<0.05) in SS(Nox4-/-) compared with SS rats in the renal cortex...
  24. Koike S, Yano S, Tanaka S, Sheikh A, Nagai A, Sugimoto T. Advanced Glycation End-Products Induce Apoptosis of Vascular Smooth Muscle Cells: A Mechanism for Vascular Calcification. Int J Mol Sci. 2016;17: pubmed publisher
    ..AGE3-BSA significantly increased the mRNA expression of NAD(P)H oxidase components including Nox4 and p22(phox), and these findings were confirmed by protein levels using immunofluorescence...
  25. Thandavarayan R, Watanabe K, Ma M, Gurusamy N, Veeraveedu P, Konishi T, et al. Dominant-negative p38alpha mitogen-activated protein kinase prevents cardiac apoptosis and remodeling after streptozotocin-induced diabetes mellitus. Am J Physiol Heart Circ Physiol. 2009;297:H911-9 pubmed publisher
    ..Moreover, LV expression of NADPH oxidase subunits, p22(phox), p67(phox), gp91(phox), and Nox4, reactive oxygen species and lipid peroxidation levels were significantly ..
  26. Wang Y, Zhang F, Liu Y, Yin S, Pang X, Li Z, et al. Nebivolol alleviates aortic remodeling through eNOS upregulation and inhibition of oxidative stress in l-NAME-induced hypertensive rats. Clin Exp Hypertens. 2017;39:628-639 pubmed publisher
    ..p-eNOS), Akt, and Akt phosphorylated at Ser473 (p-Akt) decreased, whereas that of Nox2, Nox4, and p22phox increased in the aortas from l-NAME-treated rats...
  27. Tsurusaki Y, Saitoh S, Tomizawa K, Sudo A, Asahina N, Shiraishi H, et al. A DYNC1H1 mutation causes a dominant spinal muscular atrophy with lower extremity predominance. Neurogenetics. 2012;13:327-32 pubmed publisher
    ..their mother who showed a unique quadriceps-dominant form of neurogenic muscular atrophy disclosed a heterozygous DYNC1H1 mutation [p.H306R (c.917A>G)]...
  28. Mutch C, Poduri A, Sahin M, Barry B, Walsh C, Barkovich A. Disorders of Microtubule Function in Neurons: Imaging Correlates. AJNR Am J Neuroradiol. 2016;37:528-35 pubmed publisher
    ..and 15 patients with known mutations of the genes encoding microtubule-associated proteins (5 LIS1, 4 DCX, and 6 DYNC1H1) were carefully visually analyzed and compared...
  29. Burger D, Turner M, Munkonda M, Touyz R. Endothelial Microparticle-Derived Reactive Oxygen Species: Role in Endothelial Signaling and Vascular Function. Oxid Med Cell Longev. 2016;2016:5047954 pubmed publisher
    ..eMPs contained Nox1, Nox2, Nox4, p47(phox), p67(phox), and p22(phox) and they produced ROS which was inhibited by the Nox inhibitor, apocynin...
  30. Du M. MALT lymphoma: Genetic abnormalities, immunological stimulation and molecular mechanism. Best Pract Res Clin Haematol. 2017;30:13-23 pubmed publisher
    ..The three translocations seen in MALT lymphoma, namely t(14;18)(q32;q21)/IGH-MALT1, t(1;14)(p22;q32)/BCL10-IGH, and t(11;18)(q21;q21)/BIRC3 (API2)-MALT1 are capable of activating both canonical and non-canonical ..
  31. Patterson D, Schwarz B, Avera J, Western B, Hicks M, Krugler P, et al. Sortase-Mediated Ligation as a Modular Approach for the Covalent Attachment of Proteins to the Exterior of the Bacteriophage P22 Virus-like Particle. Bioconjug Chem. 2017;28:2114-2124 pubmed publisher
    ..of a modular approach for the covalent attachment of protein domains to the exterior of the versatile bacteriophage P22 virus-like particle (VLP) via a sortase-mediated ligation strategy...
  32. Wu Y, Lee Y, Shih H, Chen S, Cheng Y, Tsun Yee Chiu D. Glucose-6-phosphate dehydrogenase is indispensable in embryonic development by modulation of epithelial-mesenchymal transition via the NOX/Smad3/miR-200b axis. Cell Death Dis. 2018;9:10 pubmed publisher
    ..The inhibition of NADPH oxidase (NOX) activation through the loss of p22phox signaling was involved in the dysregulation of the Smad3/miR-200b axis upon G6PD knockdown...
  33. Toyo oka K, Sasaki S, Yano Y, Mori D, Kobayashi T, Toyoshima Y, et al. Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration. Hum Mol Genet. 2005;14:3113-28 pubmed
    ..Our results suggest that NDEL1 is essential for mitotic cell division and neuronal migration not only via regulation of cytoplasmic dynein function but also by modulation of katanin p60 localization and function. ..
  34. Silva J, Capettini L, da Silva J, Sales Júnior P, Cruz J, Cortes S, et al. Mechanisms of vascular dysfunction in acute phase of Trypanosoma cruzi infection in mice. Vascul Pharmacol. 2016;82:73-81 pubmed publisher
    ..COX-2, thromboxane synthase, inducible nitric oxide synthase (iNOS), p65 NF?B subunit and p22(phox) of NAD(P)H oxidase (NOX) subunit expressions were increased in vessels of chagasic animals...
  35. Lin Z, Liu Z, Li X, Li F, Hu Y, Chen B, et al. Whole-exome sequencing identifies a novel de novo mutation in DYNC1H1 in epileptic encephalopathies. Sci Rep. 2017;7:258 pubmed publisher
    ..As a result, we found two deleterious de novo mutations in DYNC1H1 and RTP1 in two trios...
  36. Ikeda Y, Horinouchi Y, Hamano H, Hirayama T, Kishi S, Izawa Ishizawa Y, et al. Dietary iron restriction alleviates renal tubulointerstitial injury induced by protein overload in mice. Sci Rep. 2017;7:10621 pubmed publisher
    ..BSA-induced increase in renal superoxide production, NADPH oxidase activity, and p22phox expression was diminished in the IRD mice...
  37. Tey S, Ahmad Annuar A, Drew A, Shahrizaila N, Nicholson G, Kennerson M. Mutation analysis of genes within the dynactin complex in a cohort of hereditary peripheral neuropathies. Clin Genet. 2016;90:127-33 pubmed publisher
    ..The cytoplasmic dynein heavy chain (DYNC1H1) gene has been implicated in various neurodegenerative disorders, and dynactin 1 (DCTN1) genes have been ..
  38. Newcomer R, Fraser L, Teschke C, Alexandrescu A. Mechanism of Protein Denaturation: Partial Unfolding of the P22 Coat Protein I-Domain by Urea Binding. Biophys J. 2015;109:2666-77 pubmed publisher
    The I-domain is an insertion domain of the bacteriophage P22 coat protein that drives rapid folding and accounts for over half of the stability of the full-length protein...
  39. Al Azzouny M, El Ruby M, Issa H, Behiry E, Elsayed N, Fayez A. Detection and putative effect of GATA4 gene variants in patients with congenital cardiac septal defects. Cell Mol Biol (Noisy-le-grand). 2016;62:10-4 pubmed
    The zinc finger transcription factor GATA4, located on chromosome 8p23.1-p22, has been implicated as a critical regulator of cardiac development during embryogenesis...
  40. Ahn B, Coblentz P, Beharry A, Patel N, Judge A, Moylan J, et al. Diaphragm Abnormalities in Patients with End-Stage Heart Failure: NADPH Oxidase Upregulation and Protein Oxidation. Front Physiol. 2016;7:686 pubmed publisher
    ..05). Patients also had increased protein levels of Nox2 subunits (p47phox, p22phox, and p67phox) and total p47phox phosphorylation, while phospho-to-total p47<..
  41. Lacaria M, El Demellawy D, McGowan Jordan J. A rare case of pediatric lipoma with t(9;12)(p22;q14) and evidence of HMGA2-NFIB gene fusion. Cancer Genet. 2017;216-217:100-104 pubmed publisher
    ..Herein, we report a rare case of pediatric lipoma with t(9;12)(p22;q14) and evidence of HMGA2-NFIB gene fusion in a 9 year-old boy...
  42. Banerjee I, Miyake Y, Nobs S, Schneider C, Horvath P, Kopf M, et al. Influenza A virus uses the aggresome processing machinery for host cell entry. Science. 2014;346:473-7 pubmed publisher
  43. Lee J, Kim H, Hong J, Wang K, Kim S, Jang J, et al. Detection of novel and potentially actionable anaplastic lymphoma kinase (ALK) rearrangement in colorectal adenocarcinoma by immunohistochemistry screening. Oncotarget. 2015;6:24320-32 pubmed
    ..by ALK FISH and a novel CAD-ALK (C35; A20) fusion variant that resulted from a paracentric inversion event inv(2)(p22-21p23) was identified by CGP...
  44. Kusama K, Bai R, Ideta A, Aoyagi Y, Okuda K, Imakawa K. Regulation of epithelial to mesenchymal transition in bovine conceptuses through the interaction between follistatin and activin A. Mol Cell Endocrinol. 2016;434:81-92 pubmed publisher
    ..We then found that FST decreased in P22 conceptuses, whereas elevated activin A found in P20 UF and endometria was further increased on P22...
  45. Li L, Ren F, Qi C, Xu L, Fang Y, Liang M, et al. Intermittent hypoxia promotes melanoma lung metastasis via oxidative stress and inflammation responses in a mouse model of obstructive sleep apnea. Respir Res. 2018;19:28 pubmed publisher
    ..Lung tissues with tumor metastasis provided evidence of increased oxidative stress, as assessed by p22phox and SOD mRNA levels and the NRF2 protein level, as well as increased inflammation, as assessed by ..
  46. Kant R, Llauró A, Rayaprolu V, Qazi S, de Pablo P, Douglas T, et al. Changes in the stability and biomechanics of P22 bacteriophage capsid during maturation. Biochim Biophys Acta Gen Subj. 2018;1862:1492-1504 pubmed publisher
    The capsid of P22 bacteriophage undergoes a series of structural transitions during maturation that guide it from spherical to icosahedral morphology. The transitions include the release of scaffold proteins and capsid expansion...
  47. Zhang J, Wang Q, Xu C, Lu Y, Hu H, Qin B, et al. MitoTEMPO Prevents Oxalate Induced Injury in NRK-52E Cells via Inhibiting Mitochondrial Dysfunction and Modulating Oxidative Stress. Oxid Med Cell Longev. 2017;2017:7528090 pubmed publisher
    ..The protein expression of Nox4, Nox2, and p22 was also detected to explore the effect of oxalate and MitoTEMPO on NADPH oxidase...
  48. Hiraoka K, Kori C, Sato K. The somatosensory-evoked potential in reaction time is gated and elicited earlier when the motor response to a somatosensory cue is faster. Neuroreport. 2017;28:451-456 pubmed publisher
    ..The latencies of frontal P22 and P40 when producing a fast motor response were shorter than those when producing a slow motor response...
  49. Jung L, Ding T, Ahn J. Evaluation of lytic bacteriophages for control of multidrug-resistant Salmonella Typhimurium. Ann Clin Microbiol Antimicrob. 2017;16:66 pubmed publisher
    ..The potential lytic bacteriophages (P22-B1, P22, PBST10, PBST13, PBST32, and PBST 35) were characterized by morphological property, heat and pH stability, ..
  50. Chauhan P, Jaiswal S, Lakhotia A, Rai A. Molecular cytogenetic characterization of two Turner syndrome patients with mosaic ring X chromosome. J Assist Reprod Genet. 2016;33:1161-8 pubmed publisher
    ..Cases 1 and 2 with ring chromosome were cytogenetically characterized as 45, X [114]/46Xr (X) (p22.11q21.32) [116] and 45, X [170]/46, Xr (X) (p22.2q21.33) [92], respectively...
  51. Chen Y, Xu Y, Li G, Li N, Yu T, Yao R, et al. Exome Sequencing Identifies De Novo DYNC1H1 Mutations Associated With Distal Spinal Muscular Atrophy and Malformations of Cortical Development. J Child Neurol. 2017;32:379-386 pubmed publisher
    ..Gly1132Glu) and a previously reported de novo heterozygous missense mutation c.10151G>A (p.Arg3384Gln) in the DYNC1H1 gene. Bioinformatics predictions for c.3395G>A and c.10151G>A indicated pathogenicity of the mutations...
  52. Masoud R, Serfaty X, Erard M, Machillot P, Karimi G, Hudik E, et al. Conversion of NOX2 into a constitutive enzyme in vitro and in living cells, after its binding with a chimera of the regulatory subunits. Free Radic Biol Med. 2017;113:470-477 pubmed publisher
    ..The activated NADPH oxidase complex from phagocytes consists in two transmembrane proteins (Nox2 and p22phox) and four cytosolic proteins (p40phox, p47phox, p67phox and Rac1-2)...
  53. Sahin K, Orhan C, Tuzcu M, Sahin N, Ozdemir O, Juturu V. Ingested capsaicinoids can prevent low-fat-high-carbohydrate diet and high-fat diet-induced obesity by regulating the NADPH oxidase and Nrf2 pathways. J Inflamm Res. 2017;10:161-168 pubmed publisher
    ..001 for all). CAPs also depressed levels of NF?B p65, gp91phox, and p22phox, essential components of NADPH oxidase, in the aorta of rats...
  54. Hossain M, Xie L, Caywood E. Prognostic factors of childhood and adolescent acute myeloid leukemia (AML) survival: evidence from four decades of US population data. Cancer Epidemiol. 2015;39:720-6 pubmed publisher
    ..Contrary to previous findings, the subtypes of AML with t(9;11)(p22;q23)MLLT3-MLL, AML without maturation and acute myelomonocytic leukemia emerged to be indicative of poor outcome.
  55. Kuru D, Tarkan Argüden Y, Ar M, Çırakoğlu A, Ongoren S, Yilmaz S, et al. Variant Philadelphia translocations with different breakpoints in six chronic myeloid leukemia patients. Turk J Haematol. 2011;28:186-92 pubmed publisher
    ..Variant Ph translocations in the 6 patients were as follows: t(7;22)(p22;q11), t(9;22;15)(q34;q11;q22), t(15;22)(p11;q11), t(1;9;22;3)(q24;q34;q11;q21), t(12;22)(p13;q11), and t(4;8;9;22)(..
  56. Lin B, Hasegawa Y, Takane K, Koibuchi N, Cao C, Kim Mitsuyama S. High-Fat-Diet Intake Enhances Cerebral Amyloid Angiopathy and Cognitive Impairment in a Mouse Model of Alzheimer's Disease, Independently of Metabolic Disorders. J Am Heart Assoc. 2016;5: pubmed publisher
    ..05) and NADPH oxidase subunits, gp91(phox) (P<0.01) and p22(phox) (P<0.01) in 5XFAD mice, but not in wild-type mice...
  57. Nagaraj C, Haitchi H, Heinemann A, Howarth P, Olschewski A, Marsh L. Increased Expression of p22phox Mediates Airway Hyperresponsiveness in an Experimental Model of Asthma. Antioxid Redox Signal. 2017;27:1460-1472 pubmed publisher
    ..Increased expression and localization of p22-PHOX were observed in biopsies of asthmatic patients...
  58. von Leden R, Khayrullina G, Moritz K, Byrnes K. Age exacerbates microglial activation, oxidative stress, inflammatory and NOX2 gene expression, and delays functional recovery in a middle-aged rodent model of spinal cord injury. J Neuroinflammation. 2017;14:161 pubmed publisher
    ..damage (8-OHdG, Oxyblot, and 3-NT), microglial-related inflammation (Iba1), NOX2 component (p47PHOX, p22PHOX, and gp91PHOX), and inflammatory (CD86, CD206, TNF?, and NF?B) gene expression (all ..
  59. Gosgnach W, Messika Zeitoun D, Gonzalez W, Philipe M, Michel J. Shear stress induces iNOS expression in cultured smooth muscle cells: role of oxidative stress. Am J Physiol Cell Physiol. 2000;279:C1880-8 pubmed
    ..Shear stress also increased the expression of both membrane subunits of NADPH oxidase p22(phox) and Mox-1...
  60. Johansen L, Naumanen T, Knudsen A, Westerlund N, Gromova I, Junttila M, et al. IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration. J Cell Sci. 2008;121:854-64 pubmed publisher
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    Autosomal dominant mutations of DYNC1H1 cause a range of neurogenetic diseases, including mental retardation with cortical malformations, hereditary spastic paraplegia and spinal muscular atrophy...
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    ..These data suggest a model in which dynein accumulates and binds to the female pronucleus on sperm aster microtubules, where it interacts with dynactin, nucleoporins and vimentin. ..
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    ..ToCV) (genus Crinivirus, family Closteroviridae) encodes an RNA silencing suppressor, the protein p22, that has been described as having one of the longest lasting local suppressor activities when assayed in ..
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    ..Two of these clones, gHDHC7 and gMDHC7, are homologous genes encoding axonemal inner arm dyneins. While the human clone is assigned to 3p21, the mouse gene maps to chromosome 14. ..
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    ..The interaction of Snapin with both IncB and dynein has been shown in vitro and in vivo. We propose that Snapin connects chlamydial inclusions with the microtubule network by interacting with both IncB and dynein. ..
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    ..The final karyotype of the probands was: 46,Y,der(X),t(X;Y)(p22;q12).ish der(X)(DXYS129-,DXYS153-)mat.arr[hg19] Xp22.33(61091_2689408)×1mat,Xp22.33(2701273_3258404)×0mat,Yq11...
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