DVL3

Summary

Gene Symbol: DVL3
Description: dishevelled segment polarity protein 3
Alias: DRS3, segment polarity protein dishevelled homolog DVL-3, dishevelled 3 (homologous to Drosophila dsh), dishevelled, dsh homolog 3
Species: human
Products:     DVL3

Top Publications

  1. Angers S, Thorpe C, Biechele T, Goldenberg S, Zheng N, MacCoss M, et al. The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation. Nat Cell Biol. 2006;8:348-57 pubmed
  2. Huang T, Xie Z, Wang J, Li M, Jing N, Li L. Nuclear factor of activated T cells (NFAT) proteins repress canonical Wnt signaling via its interaction with Dishevelled (Dvl) protein and participate in regulating neural progenitor cell proliferation and differentiation. J Biol Chem. 2011;286:37399-405 pubmed publisher
    ..Our findings suggest that NFAT negatively regulates canonical Wnt/?-catenin signaling by binding to Dvl, thereby participating in vertebrate neurogenesis. ..
  3. Holloway K, Calhoun T, Saxena M, Metoyer C, Kandler E, Rivera C, et al. SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling. Proc Natl Acad Sci U S A. 2010;107:9216-21 pubmed publisher
    ..In contrast, here we report that SIRT1 regulates Dvl protein levels and Wnt signaling in several cellular contexts. These findings demonstrate that SIRT1 is a regulator of transient and constitutive Wnt signaling. ..
  4. Tauriello D, Haegebarth A, Kuper I, Edelmann M, Henraat M, Canninga Van Dijk M, et al. Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl. Mol Cell. 2010;37:607-19 pubmed publisher
    ..Together, our results argue that loss of CYLD instigates tumor growth in human cylindromatosis through a mechanism in which hyperubiquitination of polymerized Dvl drives enhancement of Wnt responses...
  5. Chan D, Chan C, Yam J, Ching Y, Ng I. Prickle-1 negatively regulates Wnt/beta-catenin pathway by promoting Dishevelled ubiquitination/degradation in liver cancer. Gastroenterology. 2006;131:1218-27 pubmed
    ..The expression levels of human Prickle-1 and Dvl3 were examined in HCC cell lines and human HCC samples...
  6. Wu C, Wei W, Li C, Li Q, Sheng Q, Zeng R. Delicate analysis of post-translational modifications on Dishevelled 3. J Proteome Res. 2012;11:3829-37 pubmed publisher
    ..In this study, we focused on low abundant Dvl3, one of the three Dvl isoforms...
  7. Sakanaka C, Leong P, Xu L, Harrison S, Williams L. Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function. Proc Natl Acad Sci U S A. 1999;96:12548-52 pubmed
    ..CKIepsilon appears to be a positive regulator of the pathway and a link between upstream signals and the complexes that regulate beta-catenin. ..
  8. Gray R, Bayly R, Green S, Agarwala S, Lowe C, Wallingford J. Diversification of the expression patterns and developmental functions of the dishevelled gene family during chordate evolution. Dev Dyn. 2009;238:2044-57 pubmed publisher
    ..Most strikingly, we report a novel role for Dvl3 in the maintenance of gene expression in muscle and in the development of the Xenopus sclerotome...
  9. Mamidi A, Inui M, Manfrin A, Soligo S, Enzo E, Aragona M, et al. Signaling crosstalk between TGFβ and Dishevelled/Par1b. Cell Death Differ. 2012;19:1689-97 pubmed publisher
    ..Mechanistically, the assembly of the Par1b/Dvl3/Smad4 complex is fostered by Wnt5a...

More Information

Publications98

  1. Li L, Mao B, Yan M, Wu S, Ge R, Lian Q, et al. Planar cell polarity protein Dishevelled 3 (Dvl3) regulates ectoplasmic specialization (ES) dynamics in the testis through changes in cytoskeletal organization. Cell Death Dis. 2019;10:194 pubmed publisher
    ..and with the technique of RNA interference (RNAi) to knockdown PCP protein Dishevelled (Dvl) 1 (Dvl1), Dvl2, Dvl3, or Dvl1/2/3, Dvl proteins, in particular Dvl3, it was shown that Dvl3 played a crucial role of support Sertoli ..
  2. Harnoš J, Canizal M, Jurásek M, Kumar J, Holler C, Schambony A, et al. Dishevelled-3 conformation dynamics analyzed by FRET-based biosensors reveals a key role of casein kinase 1. Nat Commun. 2019;10:1804 pubmed publisher
    ..In summary, our study describes an experimental tool for DVL conformational sampling in living cells and elucidates the essential regulatory role of CK1ɛ in DVL conformational dynamics. ..
  3. Danyel M, Kortüm F, Dathe K, Kutsche K, Horn D. Autosomal dominant Robinow syndrome associated with a novel DVL3 splice mutation. Am J Med Genet A. 2018;176:992-996 pubmed publisher
    ..We identified the novel de novo splice acceptor mutation c.1715-2A > C in DVL3 in a 15-year-old female patient with typical features of Robinow syndrome...
  4. Mansour T, Lucot K, Konopelski S, Dickinson P, Sturges B, Vernau K, et al. Whole genome variant association across 100 dogs identifies a frame shift mutation in DISHEVELLED 2 which contributes to Robinow-like syndrome in Bulldogs and related screw tail dog breeds. PLoS Genet. 2018;14:e1007850 pubmed publisher
    ..Importantly, analogous frameshift mutations in the human DVL1 and DVL3 genes cause Robinow syndrome, a congenital disorder characterized by similar craniofacial, limb and vertebral ..
  5. Li X, Liu S, Cha N, Zhao Y, Wang S, Li W, et al. Transcription expression and clinical significance of dishevelled-3 mRNA and δ-catenin mRNA in pleural effusions from patients with lung cancer. Clin Dev Immunol. 2012;2012:904946 pubmed publisher
    ..0%, NPV of 100.0%, and accuracy of 96.0%, respectively. As molecular markers of detecting pleural micrometastasis, DVL-3 mRNA and δ-catenin mRNA are helpful to diagnose the cancer cells in pleural effusions of patients with lung cancer. ..
  6. Chen X, Jiang J, Wang X, Zhang C, Ji A, Chen X. Role and mechanism of Dvl3 in the esophageal squamous cell carcinoma. Eur Rev Med Pharmacol Sci. 2018;22:7716-7725 pubmed publisher
    The purpose of this project was to investigate the expression of Dishevelled-3 (Dvl3) in esophageal squamous cell carcinoma and cultured cells, and to determine the consequence of Dvl3 silencing in the tumorous properties of esophageal ..
  7. Rolph D, Deb M, Kanji S, Greene C, Das M, Joseph M, et al. Ferutinin directs dental pulp-derived stem cells towards the osteogenic lineage by epigenetically regulating canonical Wnt signaling. Biochim Biophys Acta Mol Basis Dis. 2018;: pubmed publisher
    ..evaluate the role of ferutinin in epigenetic regulation of canonical Wnt signaling, the pathway molecules Wnt3a and Dvl3 were analyzed using chromatin immunoprecipitation (ChIP)-quantitative PCR approaches...
  8. Wang J, Qian J, Hoeksema M, Zou Y, Espinosa A, Rahman S, et al. Integrative genomics analysis identifies candidate drivers at 3q26-29 amplicon in squamous cell carcinoma of the lung. Clin Cancer Res. 2013;19:5580-90 pubmed publisher
    ..The meta-analysis identified 20 consensus candidates, among which four (SENP2, DCUN1D1, DVL3, and UBXN7) are involved in a small protein-protein interaction network...
  9. Cui Y, Fang W, Li C, Tang K, Zhang J, Lei Y, et al. Development and Validation of a Novel Signature to Predict Overall Survival in "Driver Gene-negative" Lung Adenocarcinoma (LUAD): Results of a Multicenter Study. Clin Cancer Res. 2019;25:1546-1556 pubmed publisher
    ..Finally, a Wnt/β-catenin pathway-based CSDW signature comprising 4 genes (CTNNB1 or β-catenin, SOX9, DVL3, and Wnt2b) was developed to classify patients into high-risk and low-risk groups in the training cohort...
  10. Zhang J, Yang J, Han D, Zhao X, Ma J, Ban B, et al. Dvl3 polymorphism interacts with life events and pro-inflammatory cytokines to influence major depressive disorder susceptibility. Sci Rep. 2018;8:14181 pubmed publisher
    The purpose of this study is to explore Dvl3 variants and their interaction with negative life events on MDD susceptibility in a Chinese Han population...
  11. Sharma M, Castro Piedras I, Simmons G, Pruitt K. Dishevelled: A masterful conductor of complex Wnt signals. Cell Signal. 2018;47:52-64 pubmed publisher
    ..Subsequently, the vertebrate homolog of Dishevelled genes were identified in Xenopus (Xdsh), mice (Dvl1, Dvl2, Dvl3), and in humans (DVL1, DVL2, DVL3) [5-10]...
  12. Sewduth R, Jaspard Vinassa B, Peghaire C, Guillabert A, Franzl N, Larrieu Lahargue F, et al. The ubiquitin ligase PDZRN3 is required for vascular morphogenesis through Wnt/planar cell polarity signalling. Nat Commun. 2014;5:4832 pubmed publisher
    ..PDZRN3 ubiquitinates Dishevelled 3 (Dvl3), to promote endocytosis of the Frizzled/Dvl3 complex, for PCP signal transduction...
  13. Lo R, Leung C, Chan K, Ho D, Wong C, Lee T, et al. Cripto-1 contributes to stemness in hepatocellular carcinoma by stabilizing Dishevelled-3 and activating Wnt/?-catenin pathway. Cell Death Differ. 2018;25:1426-1441 pubmed publisher
    ..of Cripto-1 to Frizzled-7 (FZD7), low-density lipoprotein receptor-related protein 6 (LRP6) and Dishevelled-3 (DVL3) of the Wnt/?-catenin pathway and stabilized DVL3 protein...
  14. Dijksterhuis J, Baljinnyam B, Stanger K, Sercan H, Ji Y, Andres O, et al. Systematic mapping of WNT-FZD protein interactions reveals functional selectivity by distinct WNT-FZD pairs. J Biol Chem. 2015;290:6789-98 pubmed publisher
    ..Surprisingly, different WNT-FZD pairs showed differential effects on phosphorylation of DVL2 and DVL3, revealing a previously unappreciated DVL isoform selectivity by different WNT-FZD pairs in 32D cells...
  15. Oda T, Chiba S, Nagai T, Mizuno K. Binding to Cep164, but not EB1, is essential for centriolar localization of TTBK2 and its function in ciliogenesis. Genes Cells. 2014;19:927-40 pubmed publisher
  16. Gammons M, Rutherford T, Steinhart Z, Angers S, Bienz M. Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay. J Cell Sci. 2016;129:3892-3902 pubmed
    ..Here, we generate a human cell line devoid of endogenous Dishevelled (DVL1- DVL3), which lacks Wnt signal transduction to ?-catenin...
  17. Wang L, Xiao Y, Tian T, Jin L, Lei Y, Finnell R, et al. Digenic variants of planar cell polarity genes in human neural tube defect patients. Mol Genet Metab. 2018;124:94-100 pubmed publisher
    ..These candidate genes were PCP genes, including VANGL1, VANGL2, CELSR1, SCRIB, DVL2, DVL3 and PTK7. Candidate variants were validated using Sanger sequencing...
  18. Bayod S, Felice P, Andrés P, Rosa P, Camins A, Pallàs M, et al. Downregulation of canonical Wnt signaling in hippocampus of SAMP8 mice. Neurobiol Aging. 2015;36:720-9 pubmed publisher
    ..Moreover, nuclear levels of Dvl3 were lower in 9- and 12-month-old SAMP8 mice...
  19. Ding V, Lin L, Chiang A, McCormick F. Activation of p53 by Dishevelled independent of Wnt or planar polarity pathways. J Mol Med (Berl). 2007;85:1281-9 pubmed
    ..The MAP kinase pathway and E1B55k may also be involved in this dishevelled-p53 connection. Our data provide evidence that there is a novel signaling pathway from Dishevelled to p53. ..
  20. Belinson H, Nakatani J, Babineau B, Birnbaum R, Ellegood J, Bershteyn M, et al. Prenatal β-catenin/Brn2/Tbr2 transcriptional cascade regulates adult social and stereotypic behaviors. Mol Psychiatry. 2016;21:1417-33 pubmed publisher
    ..We generated a mouse model with mutations in two Disheveled genes, Dvl1 and Dvl3, that displays adult social and repetitive behavioral abnormalities associated with transient embryonic brain ..
  21. Linke F, Zaunig S, Nietert M, von Bonin F, Lutz S, Dullin C, et al. WNT5A: a motility-promoting factor in Hodgkin lymphoma. Oncogene. 2017;36:13-23 pubmed publisher
    ..Overexpression of DVL3-K435M or inhibition of ROCK (Rho-associated protein kinase) by Y-27632/H1152P disrupted cHL cell migration...
  22. Zou Y, Xie C, Yang S, Xiong J. AMPK activators suppress breast cancer cell growth by inhibiting DVL3-facilitated Wnt/?-catenin signaling pathway activity. Mol Med Rep. 2017;15:899-907 pubmed publisher
    ..AMPK activator metformin impaired breast cancer cell growth by reducing dishevelled segment polarity protein 3 (DVL3) and ??catenin levels...
  23. Hosseini Farahabadi S, Gignac S, Danescu A, Fu K, Richman J. Abnormal WNT5A Signaling Causes Mandibular Hypoplasia in Robinow Syndrome. J Dent Res. 2017;96:1265-1272 pubmed publisher
    ..Autosomal dominant RS is caused by missense mutations in WNT5A or nonsense mutations in the adaptor protein DVL1 or DVL3. The recessive form of the disease is caused by loss-of-function mutations in the receptor ROR2...
  24. Paclíková P, Bernatik O, Radaszkiewicz T, Bryja V. The N-Terminal Part of the Dishevelled DEP Domain Is Required for Wnt/β-Catenin Signaling in Mammalian Cells. Mol Cell Biol. 2017;37: pubmed publisher
    ..In this study, we took advantage of DVL knockout (DVL1/DVL2/DVL3 triple knockout) cells fully deficient in Wnt3a-induced signaling events and performed a series of rescue ..
  25. Xie Y, Zhang H, Guo X, Feng Y, He R, Li X, et al. Let-7c inhibits cholangiocarcinoma growth but promotes tumor cell invasion and growth at extrahepatic sites. Cell Death Dis. 2018;9:249 pubmed publisher
    ..malignant biological properties, at least in part, through regulation of EZH2 protein expression and through the DVL3/β-catenin axis...
  26. Zhan Y, Luo Q, Zhang X, Xiao N, Lu C, Yue C, et al. CELSR1 Is a Positive Regulator of Endothelial Cell Migration and Angiogenesis. Biochemistry (Mosc). 2016;81:591-9 pubmed publisher
    ..CELSR1-regulated migration and tube formation was mediated through disheveled segment polarity protein 3 (Dvl3)...
  27. Peghaire C, Bats M, Sewduth R, Jeanningros S, Jaspard B, Couffinhal T, et al. Fzd7 (Frizzled-7) Expressed by Endothelial Cells Controls Blood Vessel Formation Through Wnt/β-Catenin Canonical Signaling. Arterioscler Thromb Vasc Biol. 2016;36:2369-2380 pubmed
    ..We found that Dvl3 depletion in dvl1-/- mice mimicked the fzd7ECKO vascular phenotype and demonstrated that Fzd7 ..
  28. Chen Q, Jiao D, Zhu Y, Hu H, Wang J, Tang X, et al. Identification of carcinogenic potential-associated molecular mechanisms in CD133(+) A549 cells based on microRNA profiles. Tumour Biol. 2016;37:521-30 pubmed publisher
    ..g., DVL1, DVL3, WNT3A, and WNT5A)...
  29. Chen Z, Lei Y, Cao X, Zheng Y, Wang F, Bao Y, et al. Genetic analysis of Wnt/PCP genes in neural tube defects. BMC Med Genomics. 2018;11:38 pubmed publisher
    ..001). Functional studies indicated compound heterozygote variants of CELSR2 p.Thr2026Met and DVL3 p.Asp403Asn result in down regulation of PCP signals...
  30. Jin Y, Zhou J, Xu F, Jin B, Cui L, Wang Y, et al. Targeting methyltransferase PRMT5 eliminates leukemia stem cells in chronic myelogenous leukemia. J Clin Invest. 2016;126:3961-3980 pubmed publisher
    ..inhibition of PRMT5 abrogated the Wnt/?-catenin pathway in CML CD34+ cells by depleting dishevelled homolog 3 (DVL3)...
  31. Sue Ng S, Mahmoudi T, Li V, Hatzis P, Boersema P, Mohammed S, et al. MAP3K1 functionally interacts with Axin1 in the canonical Wnt signalling pathway. Biol Chem. 2010;391:171-80 pubmed publisher
    ..These results suggest that MAP3K1, previously reported as an Axin1 inter-actor in c-Jun NH(2)-terminal kinase pathway, is also involved in the canonical Wnt signalling pathway and positively regulates expression of Wnt target genes. ..
  32. White J, Mazzeu J, Coban Akdemir Z, Bayram Y, Bahrambeigi V, Hoischen A, et al. WNT Signaling Perturbations Underlie the Genetic Heterogeneity of Robinow Syndrome. Am J Hum Genet. 2018;102:27-43 pubmed publisher
    ..reside in genes within the noncanonical Wnt signaling pathway including ROR2, WNT5A, and more recently, DVL1 and DVL3. However, ∼70% of autosomal-dominant Robinow syndrome cases remain molecularly unsolved...
  33. Le L, Swingler T, Crowe N, Vincent T, Barter M, Donell S, et al. The microRNA-29 family in cartilage homeostasis and osteoarthritis. J Mol Med (Berl). 2016;94:583-96 pubmed publisher
    ..Expression profiles revealed regulation of new WNT-related genes. Amongst these, FZD3, FZD5, DVL3, FRAT2, and CK2A2 were validated as direct targets of the miR-29 family...
  34. Fukukawa C, Nagayama S, Tsunoda T, Toguchida J, Nakamura Y, Katagiri T. Activation of the non-canonical Dvl-Rac1-JNK pathway by Frizzled homologue 10 in human synovial sarcoma. Oncogene. 2009;28:1110-20 pubmed publisher
    ..We found a significant enhancement of phosphorylation of the Dishevelled (Dvl)2/Dvl3 complex as well as activation of the Rac1-JNK cascade in synovial sarcoma cells in which FZD10 was overexpressed...
  35. Lee Y, Gao Y, Wang H. Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3. Cell Signal. 2008;20:443-52 pubmed
    ..the genomes of higher organism (including mammals), three genes encoding isoforms of Dishevelled (Dvl1, Dvl2, and Dvl3) are present...
  36. Bernatik O, Sedova K, Schille C, Ganji R, Cervenka I, Trantirek L, et al. Functional analysis of dishevelled-3 phosphorylation identifies distinct mechanisms driven by casein kinase 1ϵ and frizzled5. J Biol Chem. 2014;289:23520-33 pubmed publisher
    Dishevelled-3 (Dvl3), a key component of the Wnt signaling pathways, acts downstream of Frizzled (Fzd) receptors and gets heavily phosphorylated in response to pathway activation by Wnt ligands...
  37. Tsui Y, Sze K, Tung E, Ho D, Lee T, Ng I. Dishevelled-3 phosphorylation is governed by HIPK2/PP1Cα/ITCH axis and the non-phosphorylated form promotes cancer stemness via LGR5 in hepatocellular carcinoma. Oncotarget. 2017;8:39430-39442 pubmed publisher
    Dishevelled-3 (Dvl3) is regarded as a binding hub with many different interacting partners. However, its regulation and mechanism on cancer stemness remain to be explored...
  38. Kim P, Park J, Kim H, Cho Y, Go H. Dishevelled segment polarity protein 3 (DVL3): a novel and easily applicable recurrence predictor in localised prostate adenocarcinoma. BJU Int. 2017;120:343-350 pubmed publisher
    ..001). Cyclin B1 (CCNB1), dishevelled segment polarity protein 3 (DVL3), paxillin (PXN), RAF1, transferrin, X-ray repair cross complementing 5 (XRCC5) and BIM had lower expression in the ..
  39. de Groot R, Ganji R, Bernatik O, Lloyd Lewis B, Seipel K, Sedova K, et al. Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the Wnt signaling pathway. Sci Signal. 2014;7:ra26 pubmed publisher
    ..Our findings indicate that Huwe1 is part of an evolutionarily conserved negative feedback loop in the Wnt/?-catenin pathway. ..
  40. El Hassan A, Leung V, Kharfallah F, Guyot M, Allache R, Gros P, et al. Identification and characterization of a novel chemically induced allele at the planar cell polarity gene Vangl2. Mamm Genome. 2018;29:229-244 pubmed publisher
    ..The Vangl2I268N variant no longer physically interacts with its PCP partner DVL3 and has a reduced protein half-life...
  41. Strovel E, Wu D, Sussman D. Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription. J Biol Chem. 2000;275:2399-403 pubmed
    ..PP2C utilizes Axin as a substrate both in vitro and in vivo and decreases its half-life. These results indicate that PP2C is a positive regulator of Wnt signal transduction and mediates its effects through the dephosphorylation of Axin. ..
  42. Li T, Hou S, Mao J, Wang Y, Lu X, Tan J, et al. The expression of Dishevelled-3 and glutamine metabolism in malignant pleural mesothelioma. J Clin Pathol. 2012;65:855-8 pubmed publisher
  43. Bui T, Beier D, Jonssen M, Smith K, Dorrington S, Kaklamanis L, et al. cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27, and expression in human breast and colon carcinomas. Biochem Biophys Res Commun. 1997;239:510-6 pubmed
    ..The data indicates that DVL-3 is widely expressed in human cells and supports the notion of a new developmental gene family for dishevelled which may have a widespread role in signal transduction. ..
  44. Song D, Sussman D, Seldin D. Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells. J Biol Chem. 2000;275:23790-7 pubmed
    ..These results demonstrate that endogenous CK2 is a positive regulator of Wnt signaling and growth of mammary epithelial cells. ..
  45. Pecina Slaus N, Kafka A, Bukovac A, Vladusić T, Tomas D, Hrascan R. Genetic changes of MLH1 and MSH2 genes could explain constant findings on microsatellite instability in intracranial meningioma. Tumour Biol. 2017;39:1010428317705791 pubmed publisher
    ..Furthermore, genes DVL3 (D3S1262), AXIN1 (D16S3399), and CDH1 (D16S752) were also investigated for microsatellite instability...
  46. Chen D, Mi J, Wu M, Wang W, Gao H. Expression of dishevelled gene in Hirschsprung's disease. Int J Clin Exp Pathol. 2013;6:1791-8 pubmed
    ..The study showed an association of DVL-1 and DVL-3 with HSCR, it may play an important role in the pathogenesis of HSCR. ..
  47. Zhao H, Zhao Y, Jiang G, Zhang X, Zhang Y, Dong Q, et al. Dishevelled-3 activates p65 to upregulate p120-catenin transcription via a p38-dependent pathway in non-small cell lung cancer. Mol Carcinog. 2015;54 Suppl 1:E112-21 pubmed publisher
    ..Dvl-3 activates a p38 → p65 → PAX2 → p120ctn pathway to affect biological behavior of NSCLC cells. ..
  48. Zhao G, Jiang K, Zhang T, Wu H, Qiu C, Deng G. Specific interferon tau gene-regulation networks in bovine endometrial luminal epithelial cells. Theriogenology. 2018;105:51-60 pubmed publisher
    ..A set of candidate genes (RAC2, DVL3, PSMB9, STAT1, ISG15, JAK1, and MUC1) was identified...
  49. White J, Mazzeu J, Hoischen A, Bayram Y, Withers M, Gezdirici A, et al. DVL3 Alleles Resulting in a -1 Frameshift of the Last Exon Mediate Autosomal-Dominant Robinow Syndrome. Am J Hum Genet. 2016;98:553-561 pubmed publisher
    ..location of frameshift variants in DVL1-mediated Robinow syndrome and the functional redundancy of DVL1, DVL2, and DVL3, we elected to pursue direct Sanger sequencing of the penultimate exon of DVL1 and its paralogs DVL2 and DVL3 to ..
  50. Wei Q, Zhao Y, Yang Z, Dong Q, Dong X, Han Y, et al. Dishevelled family proteins are expressed in non-small cell lung cancer and function differentially on tumor progression. Lung Cancer. 2008;62:181-92 pubmed publisher
    ..Expression of Dvl family proteins, Dvl-1, Dvl-2 and Dvl-3, is common in NSCLCs. They may contribute to the progression of NSCLCs, but Dvl-1 and Dvl-3 may function on this process through different signaling pathways. ..
  51. Pizzuti A, Amati F, Calabrese G, Mari A, Colosimo A, Silani V, et al. cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene. Hum Mol Genet. 1996;5:953-8 pubmed
    ..Although the precise role of these genes in embryogenesis is only conjectural at present, the structural and evolutionary characteristics suggest that mutations at their loci may be involved in neural and heart developmental defects. ..
  52. Yuan W, Liu Z, Lei W, Sun L, Yang H, Wang Y, et al. Mutation landscape and intra-tumor heterogeneity of two MANECs of the esophagus revealed by multi-region sequencing. Oncotarget. 2017;8:69610-69621 pubmed publisher
    ..i>TP53 mutation, RB1 deletion or LOH, and PIK3CA, PTEN, KRAS, SOX2, DVL3, TP63 amplification appeared in all regions in both tumors...
  53. Yang Y, Liu M, Li D, Ran J, Gao J, Suo S, et al. CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation. Proc Natl Acad Sci U S A. 2014;111:2158-63 pubmed publisher
    ..These findings uncover CYLD as an important player in the orientation of the mitotic spindle and cell division and have important implications in health and disease. ..
  54. Velázquez D, Castañeda Patlán M, Robles Flores M. Dishevelled stability is positively regulated by PKC?-mediated phosphorylation induced by Wnt agonists. Cell Signal. 2017;35:107-117 pubmed publisher
    ..In addition, we found that Wnt3a treatment rapidly induces hyperphosphorylation and stabilization of Dvl2 and Dvl3. The latter can be blocked by inhibition of Protein Kinase C (PKC)?, PKC?, and PKC? isoforms...
  55. Khan A, Hojjat Farsangi M, Daneshmanesh A, Hansson L, Kokhaei P, Osterborg A, et al. Dishevelled proteins are significantly upregulated in chronic lymphocytic leukaemia. Tumour Biol. 2016;37:11947-11957 pubmed
    ..The expression of DVL1 and DVL3 proteins was significantly more pronounced in progressive than in non-progressive disease (p?<?0...
  56. Schueler M, Braun D, Chandrasekar G, Gee H, Klasson T, Halbritter J, et al. DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling. Am J Hum Genet. 2015;96:81-92 pubmed publisher
    ..We thus demonstrate a central role of Wnt signaling in the pathogenesis of NPHP-RC, suggesting an avenue for potential treatment of NPHP-RC. ..
  57. He H, Chen K, Wang F, Zhao L, Wan X, Wang L, et al. miR-204-5p promotes the adipogenic differentiation of human adipose-derived mesenchymal stem cells by modulating DVL3 expression and suppressing Wnt/β-catenin signaling. Int J Mol Med. 2015;35:1587-95 pubmed publisher
    ..used bioinformatics tools and luciferase reporter assay to establish that dishevelled segment polarity protein 3 (DVL3), a key regulator of the Wnt/β-catenin signaling pathway, is a direct target of miR-204-5p...
  58. Hegazy S, Alshareef A, Gelebart P, Anand M, Armanious H, Ingham R, et al. Disheveled proteins promote cell growth and tumorigenicity in ALK-positive anaplastic large cell lymphoma. Cell Signal. 2013;25:295-307 pubmed publisher
    ..To our knowledge, this is the first report demonstrating a physical and functional interaction between the Dvls and an oncogenic tyrosine kinase. ..
  59. Chaki M, Airik R, Ghosh A, Giles R, Chen R, Slaats G, et al. Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling. Cell. 2012;150:533-48 pubmed publisher
    ..Our findings link degenerative diseases of the kidney and retina, disorders of increasing prevalence, to mechanisms of DDR. ..
  60. Li V, Ng S, Boersema P, Low T, Karthaus W, Gerlach J, et al. Wnt signaling through inhibition of ?-catenin degradation in an intact Axin1 complex. Cell. 2012;149:1245-56 pubmed publisher
    ..Subsequently, newly synthesized ?-catenin can accumulate in a free cytosolic form and engage nuclear TCF transcription factors. ..
  61. Varelas X, Miller B, Sopko R, Song S, Gregorieff A, Fellouse F, et al. The Hippo pathway regulates Wnt/beta-catenin signaling. Dev Cell. 2010;18:579-91 pubmed publisher
    ..These results uncover a cytoplasmic function of TAZ in regulating Wnt signaling and highlight the role of the Hippo pathway in coordinating morphogenetic signaling with growth control. ..
  62. Kishida S, Yamamoto H, Hino S, Ikeda S, Kishida M, Kikuchi A. DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability. Mol Cell Biol. 1999;19:4414-22 pubmed
    ..These results indicate that the DIX domains of Dvl-1 and Axin are important for protein-protein interactions and that they are necessary for the ability of Dvl-1 and Axin to regulate the stability of beta-catenin. ..
  63. Rao C, Lin S, Ruan W, Wen H, Wu D, Deng H. High expression of IGFBP7 in fibroblasts induced by colorectal cancer cells is co-regulated by TGF-? and Wnt signaling in a Smad2/3-Dvl2/3-dependent manner. PLoS ONE. 2014;9:e85340 pubmed publisher
    ..Taken together, these data suggest that the fibroblasts could be a novel therapeutic target in tumor therapy. ..
  64. Kafka A, Tomas D, Lechpammer M, Gabud T, Pazanin L, Pecina Slaus N. Expression Levels and Localizations of DVL3 and sFRP3 in Glioblastoma. Dis Markers. 2017;2017:9253495 pubmed publisher
    The expression patterns of critical molecular components of Wnt signaling, sFRP3 and DVL3, were investigated in glioblastoma, the most aggressive form of primary brain tumors, with the aim to offer potential biomarkers...
  65. Gnad T, Feoktistova M, Leverkus M, Lendeckel U, Naumann M. Helicobacter pylori-induced activation of beta-catenin involves low density lipoprotein receptor-related protein 6 and Dishevelled. Mol Cancer. 2010;9:31 pubmed publisher
    ..Further, we identified proteins of the Dvl family, namely Dvl2 and Dvl3, which are involved in LRP6 phosphorylation. H...
  66. Jansen R, Penninx B, Madar V, Xia K, Milaneschi Y, Hottenga J, et al. Gene expression in major depressive disorder. Mol Psychiatry. 2016;21:339-47 pubmed publisher
    ..to the Psychiatric Genomics Consortium (PGC) MDD genome-wide association study results revealed overlap with DVL3. In conclusion, multiple gene expression associations with MDD were identified and suggest a measurable impact of ..
  67. Wang Y, Wu W, Zhu M, Wang C, Shen W, Cheng Y, et al. Integrating expression related SNPs into genome-wide gene-pathway-based analysis identified novel lung cancer susceptibility genes. Int J Cancer. 2017;: pubmed publisher
    ..1 in 6q27, and MPZL3 in 11q23.3). Besides, DVL3 (3q27.1), RP11-522I20.3 (9q21.32), and CCDC116 (22q11.21) were identified as novel lung cancer susceptibility genes...
  68. Semenov M, Snyder M. Human dishevelled genes constitute a DHR-containing multigene family. Genomics. 1997;42:302-10 pubmed
    ..Indirect immunofluorescence indicates that it is found throughout the cytoplasm. Our results indicate that the human dishevelled genes constitute a multigene family and that Dishevelled proteins are highly conserved among metazoans. ..
  69. Yan D, Wallingford J, Sun T, Nelson A, Sakanaka C, Reinhard C, et al. Cell autonomous regulation of multiple Dishevelled-dependent pathways by mammalian Nkd. Proc Natl Acad Sci U S A. 2001;98:3802-7 pubmed
    ..These data suggest that mNkd may act as a switch to direct Dishevelled activity toward the PCP pathway, and away from the canonical Wnt pathway. ..
  70. Kadir R, Harel T, Markus B, Perez Y, Bakhrat A, Cohen I, et al. ALFY-Controlled DVL3 Autophagy Regulates Wnt Signaling, Determining Human Brain Size. PLoS Genet. 2016;12:e1005919 pubmed publisher
    ..ALFY attenuates the canonical Wnt signaling pathway via autophagy-dependent removal specifically of aggregates of DVL3 and not of Dvl1 or Dvl2...
  71. Bouteille N, Driouch K, Hage P, Sin S, Formstecher E, Camonis J, et al. Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein. Oncogene. 2009;28:2569-80 pubmed publisher
    ..Our results indicate that WWOX is a novel inhibitor of the Wnt/beta-catenin pathway. WWOX would act, at least in part, by preventing the nuclear import of the Dvl proteins. ..
  72. Kwan H, Chan D, Cai P, Mak C, Yung M, Leung T, et al. AMPK activators suppress cervical cancer cell growth through inhibition of DVL3 mediated Wnt/?-catenin signaling activity. PLoS ONE. 2013;8:e53597 pubmed publisher
    ..Here we show that AMPK activators impair cervical cancer cell growth through the reduction of DVL3, a positive regulator in Wnt/?-catenin signaling and an oncogenic player in cervical cancer tumorigenesis...
  73. De Marco P, Merello E, Consales A, Piatelli G, Cama A, Kibar Z, et al. Genetic analysis of disheveled 2 and disheveled 3 in human neural tube defects. J Mol Neurosci. 2013;49:582-8 pubmed publisher
    ..In mouse disruption of Dvl2 alone (Dvl2 (-/-)) or Dvl2 and Dvl3 (Dvl2 (-/-); Dvl3 (+/-), Dvl2 (+/-); Dvl3 (-/-)) ..
  74. Sun T, Lu B, Feng J, Reinhard C, Jan Y, Fantl W, et al. PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling. Nat Cell Biol. 2001;3:628-36 pubmed
    ..These findings show that PAR-1, a regulator of polarity, is also a modulator of Wnt-beta-catenin signalling, indicating a link between two important developmental pathways. ..
  75. Pethe V, Charames G, Bapat B. Rac1b recruits Dishevelled and ?-catenin to Wnt target gene promoters independent of Wnt3A stimulation. Int J Oncol. 2011;39:805-10 pubmed publisher
    ..Our studies suggest a novel transcriptional co-activator role of Rac1b in ?-catenin/TCF-mediated transcription. ..
  76. Cajanek L, Ganji R, Henriques Oliveira C, Theofilopoulos S, Konik P, Bryja V, et al. Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons. Mol Cell Biol. 2013;33:59-70 pubmed publisher
    ..First, we characterize the interaction between Rac1 and Dvl and identify the N-terminal part of Dvl3 as necessary for Rac1 binding...
  77. Ripke S, Wray N, Lewis C, Hamilton S, Weissman M, Breen G, et al. A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry. 2013;18:497-511 pubmed publisher
    ..The 3p21.1 MDD-BIP finding should be interpreted with caution as the most significant SNP did not replicate in MDD samples, and genotyping in independent samples will be needed to resolve its status. ..
  78. Bian W, Miao W, He S, Wan Z, Luo Z, Yu X. A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4. Dev Neurobiol. 2015;75:805-22 pubmed publisher
  79. Murata Shinozaki Y, Takahashi T, Matsubara T, Maruyama H, Izumi Y, Matsumoto M. The origins of rimmed vacuoles and granulovacuolar degeneration bodies are associated with the Wnt signaling pathway. Neurosci Lett. 2017;638:55-59 pubmed publisher
    ..The antigens probed included the following: (1) dishevelled (Dvl) family proteins (Dvl1, Dvl2 and Dvl3), (2) NMJ-associated proteins (low density lipoprotein-related protein 4 [Lrp4], heat shock protein 70 [Hsp70], ?-..
  80. Sancho R, Law B, Harvey K. Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways. Hum Mol Genet. 2009;18:3955-68 pubmed publisher
    ..Our findings also link LRRK2 to Wnt signalling pathways, suggesting novel pathogenic mechanisms and new targets for genetic analysis in Parkinson's disease. ..
  81. Torban E, Wang H, Groulx N, Gros P. Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family. J Biol Chem. 2004;279:52703-13 pubmed
    ..identified in two independent Lp alleles associated with neural tube defects impair binding to Dvl1, Dvl2, and Dvl3. These findings suggest a molecular mechanism for the neural tube defect seen in Lp mice...
  82. Hocevar B, Mou F, Rennolds J, Morris S, Cooper J, Howe P. Regulation of the Wnt signaling pathway by disabled-2 (Dab2). EMBO J. 2003;22:3084-94 pubmed
    ..Based on these results, we propose that Dab2 functions as a negative regulator of canonical Wnt signaling by stabilizing the beta-catenin degradation complex, which may contribute to its proposed role as a tumor suppressor. ..
  83. Guillabert Gourgues A, Jaspard Vinassa B, Bats M, Sewduth R, Franzl N, Peghaire C, et al. Kif26b controls endothelial cell polarity through the Dishevelled/Daam1-dependent planar cell polarity-signaling pathway. Mol Biol Cell. 2016;27:941-53 pubmed publisher
    ..First, we find that Kif26b is recruited within the Dvl3/Daam1 complex...
  84. Wei W, Li M, Wang J, Nie F, Li L. The E3 ubiquitin ligase ITCH negatively regulates canonical Wnt signaling by targeting dishevelled protein. Mol Cell Biol. 2012;32:3903-12 pubmed publisher
    ..Collectively, these results indicate that ITCH plays a negative regulatory role in modulating canonical Wnt signaling by targeting the phosphorylated form of Dvl. ..
  85. Gao S, Bajrami I, Verrill C, Kigozi A, Ouaret D, Aleksic T, et al. Dsh homolog DVL3 mediates resistance to IGFIR inhibition by regulating IGF-RAS signaling. Cancer Res. 2014;74:5866-77 pubmed publisher
    ..In this study, we used genetic screening and downstream validation to identify the WNT pathway element DVL3 as a mediator of resistance to IGFIR inhibition...
  86. Punchihewa C, Ferreira A, Cassell R, Rodrigues P, Fujii N. Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins. Protein Sci. 2009;18:994-1002 pubmed publisher
    ..Molecular modeling and circular dichroism studies indicated that the Fz peptides that bind to Dvl PDZ domain form specific conformations that are different from those of nonbinding peptides. ..
  87. Liu J, Bang A, Kintner C, Orth A, Chanda S, Ding S, et al. Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis. Proc Natl Acad Sci U S A. 2005;102:1927-32 pubmed
    ..components and previously uncharacterized regulators of this pathway were identified, including beta-catenin, Dvl1, Dvl3, Fbxw-1, Cul1, CK1epsilon, CK1delta, and gamma-catenin...
  88. Zhang X, Yu X, Jiang G, Miao Y, Wang L, Zhang Y, et al. Cytosolic TMEM88 promotes invasion and metastasis in lung cancer cells by binding DVLS. Cancer Res. 2015;75:4527-37 pubmed publisher
    ..Overall, our findings show how mislocalization of TMEM88 to the cytosol in NSCLC cells ablates its Wnt pathway regulatory properties, thereby promoting invasion and metastasis by activating the p38-GSK3β-Snail signaling pathway. ..
  89. Hino S, Kishida S, Michiue T, Fukui A, Sakamoto I, Takada S, et al. Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. Mol Cell Biol. 2001;21:330-42 pubmed
    ..Therefore, these results suggest that Idax functions as a negative regulator of the Wnt signaling pathway by directly binding to the PDZ domain of Dvl. ..