Gene Symbol: DVL2
Description: dishevelled segment polarity protein 2
Alias: segment polarity protein dishevelled homolog DVL-2, dishevelled 2 (homologous to Drosophila dsh), dishevelled, dsh homolog 2
Species: human
Products:     DVL2

Top Publications

  1. Habas R, Dawid I, He X. Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation. Genes Dev. 2003;17:295-309 pubmed
    ..We propose that parallel activation of Rac and Rho pathways by Wnt/Fz signaling is required for cell polarity and movements during vertebrate gastrulation. ..
  2. Schwarz Romond T, Fiedler M, Shibata N, Butler P, Kikuchi A, Higuchi Y, et al. The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization. Nat Struct Mol Biol. 2007;14:484-92 pubmed
    ..Here, we demonstrate that the DIX domain of Dvl2 mediates dynamic polymerization, which is essential for the signaling activity of Dvl2...
  3. Habas R, Kato Y, He X. Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1. Cell. 2001;107:843-54 pubmed
    ..Our study illustrates a molecular pathway from Wnt/Fz signaling to Rho activation in cell polarity signal transduction. ..
  4. Dang S, Zhou J, Chen Y, Chen P, Ji M, Shi B, et al. Dynamic expression of ZNF382 and its tumor-suppressor role in hepatitis B virus-related hepatocellular carcinogenesis. Oncogene. 2019;: pubmed publisher
    ..targets such as Fos proto-oncogene (FOS), Jun proto-oncogene (JUN), disheveled segment polarity protein 2 (DVL2), and frizzled class receptor 1 (FZD1), thereby impairing the activities of activating protein 1 (AP-1) and Wnt/β-..
  5. Srivastava N, Srivastava R. Curcumin and quercetin synergistically inhibit cancer cell proliferation in multiple cancer cells and modulate Wnt/β-catenin signaling and apoptotic pathways in A375 cells. Phytomedicine. 2019;52:117-128 pubmed publisher
    ..inhibition of cell proliferation occurred through down-regulation of Wnt/β-catenin signaling pathway proteins, DVL2, β-catenin, cyclin D1, Cox2, and Axin2...
  6. Zhang C, Xiang T, Li S, Ye L, Feng Y, Pei L, et al. The novel 19q13 KRAB zinc-finger tumour suppressor ZNF382 is frequently methylated in oesophageal squamous cell carcinoma and antagonises Wnt/?-catenin signalling. Cell Death Dis. 2018;9:573 pubmed publisher
    ..Wnt/?-catenin signalling and downstream target gene expression, likely through binding directly to FZD1 and DVL2 promoters...
  7. Bernaudo S, Salem M, Qi X, Zhou W, Zhang C, Yang W, et al. Cyclin G2 inhibits epithelial-to-mesenchymal transition by disrupting Wnt/β-catenin signaling. Oncogene. 2016;35:4816-27 pubmed publisher
    ..G2 potently suppressed the Wnt/β-catenin signaling pathway by downregulating key Wnt components, namely LRP6, DVL2 and β-catenin, which could be linked to inhibition of EMT...
  8. Yuan H, Li N, Fu D, Ren J, Hui J, Peng J, et al. Histone methyltransferase SETD2 modulates alternative splicing to inhibit intestinal tumorigenesis. J Clin Invest. 2017;127:3375-3391 pubmed publisher
    ..Importantly, we uncovered that SETD2 ablation reduces intron retention of dishevelled segment polarity protein 2 (DVL2) pre-mRNA, which would otherwise be degraded by nonsense-mediated decay, thereby augmenting Wnt signaling...
  9. Sun H, Wang Y, Zhang J, Chen Y, Liu Y, Lin Z, et al. CFTR mutation enhances Dishevelled degradation and results in impairment of Wnt-dependent hematopoiesis. Cell Death Dis. 2018;9:275 pubmed publisher
    ..Analysis of human database ( http://r2.amc.nl ) shows that CFTR is positively correlated with DVL2 and Wnt-related hematopoietic factors in human blood system...

More Information

Publications173 found, 100 shown here

  1. de Araujo T, Secolin R, Félix T, de Souza L, Fontes M, Monlleó I, et al. A multicentric association study between 39 genes and nonsyndromic cleft lip and palate in a Brazilian population. J Craniomaxillofac Surg. 2016;44:16-20 pubmed publisher
    ..etiology of NSCLP, including MSX1, SPRY1, MSX2, PRSS35, TFAP2A, SHH, VAX1, TBX10, WNT11, PAX9, BMP4, JAG2, AXIN2, DVL2, KIF7, and TCBE3. Stepwise regression analysis revealed that 11 genes contributed to 15...
  2. Liu C, Lin C, Gao C, May Simera H, Swaroop A, Li T. Null and hypomorph Prickle1 alleles in mice phenocopy human Robinow syndrome and disrupt signaling downstream of Wnt5a. Biol Open. 2014;3:861-70 pubmed publisher
    ..We show that Prickle1 is a proteasomal target of Wnt5a signaling and that Dvl2, a target of Wnt5a signaling, is misregulated in Prickle1 mutants...
  3. Voloshanenko O, Schwartz U, Kranz D, Rauscher B, Linnebacher M, Augustin I, et al. β-catenin-independent regulation of Wnt target genes by RoR2 and ATF2/ATF4 in colon cancer cells. Sci Rep. 2018;8:3178 pubmed publisher
    ..Moreover, non-canonical Wnt target genes are regulated via RoR2, Dvl2, ATF2 and ATF4...
  4. Rothé B, Leal Esteban L, Bernet F, Urfer S, Doerr N, Weimbs T, et al. Bicc1 Polymerization Regulates the Localization and Silencing of Bound mRNA. Mol Cell Biol. 2015;35:3339-53 pubmed publisher
    ..We conclude that polymerization is a novel disease-relevant mechanism both to stabilize Bicc1 and to present associated mRNAs in specific silencing platforms. ..
  5. Kadir R, Harel T, Markus B, Perez Y, Bakhrat A, Cohen I, et al. ALFY-Controlled DVL3 Autophagy Regulates Wnt Signaling, Determining Human Brain Size. PLoS Genet. 2016;12:e1005919 pubmed publisher
    ..Wnt signaling pathway via autophagy-dependent removal specifically of aggregates of DVL3 and not of Dvl1 or Dvl2. Thus, autophagic attenuation of Wnt signaling through removal of Dvl3 aggregates by ALFY acts in determining human ..
  6. Wang L, Brooks A, Fan J, Wan Y, Gambe R, Li S, et al. Transcriptomic Characterization of SF3B1 Mutation Reveals Its Pleiotropic Effects in Chronic Lymphocytic Leukemia. Cancer Cell. 2016;30:750-763 pubmed publisher
    ..telomere maintenance, and Notch signaling (mediated through KLF8 upregulation, increased TERC and TERT expression, or altered splicing of DVL2 transcript, respectively). SF3B1 mutation leads to diverse changes in CLL-related pathways.
  7. Cheng M, Xue H, Cao W, Li W, Chen H, Liu B, et al. Receptor for Activated C Kinase 1 (RACK1) Promotes Dishevelled Protein Degradation via Autophagy and Antagonizes Wnt Signaling. J Biol Chem. 2016;291:12871-9 pubmed publisher
    ..RACK1 also interacts with LC3 and enhances the association of LC3 with Dvl2, thereby leading to degradation of Dvl proteins through autophagy...
  8. Luo X, Liu Y, Ma S, Liu L, Xie R, Li M, et al. STIP1 is over-expressed in hepatocellular carcinoma and promotes the growth and migration of cancer cells. Gene. 2018;662:110-117 pubmed publisher
    ..Molecular mechanism study showed that STIP1 interacted with Axin, enhanced the interaction between Axin and DVL2, thus activated beta-catenin/TCF signaling...
  9. Larraguibel J, Weiss A, Pasula D, Dhaliwal R, Kondra R, Van Raay T. Wnt ligand-dependent activation of the negative feedback regulator Nkd1. Mol Biol Cell. 2015;26:2375-84 pubmed publisher
    ..Furthermore, our results support the hypothesis that Nkd1 is recruited to the Wnt signalosome with Dvl2, where it becomes activated to move into the cytoplasm to interact with β-catenin, inhibiting its nuclear ..
  10. Cao Y, Shi L, Wang M, Hou J, Wei Y, DU C. ATDC contributes to sustaining the growth and invasion of glioma cells through regulating Wnt/β-catenin signaling. Chem Biol Interact. 2019;305:148-155 pubmed publisher
    ..Moreover, our results showed that inhibition of ATDC reduced the expression levels of Dishevelled 2 (Dvl2) and β-catenin and impeded the activation of Wnt/β-catenin signaling, whereas overexpression of ATDC showed the ..
  11. Pei J, Cooper H, Flieder D, Talarchek J, Al Saleem T, Uzzo R, et al. NEAT1-TFE3 and KAT6A-TFE3 renal cell carcinomas, new members of MiT family translocation renal cell carcinoma. Mod Pathol. 2019;32:710-716 pubmed publisher
    ..Multiple 5' fusion partners for TFE3 have been reported, including ASPSCR1, CLTC, DVL2, LUC7L3, KHSRP, PRCC, PARP14, NONO, SFPQ1, MED15, and RBM10...
  12. Zhang Y, Ding Y, Chen Y, Tao Q. NEDD4L regulates convergent extension movements in Xenopus embryos via Disheveled-mediated non-canonical Wnt signaling. Dev Biol. 2014;392:15-25 pubmed publisher
    ..highly conserved HECT type E3 ligase, has been reported to regulate the stability of multiple substrates including Dvl2. Here we demonstrate that NEDD4L is required for the cellular polarity formation and convergent extension in the ..
  13. Li L, Mao B, Yan M, Wu S, Ge R, Lian Q, et al. Planar cell polarity protein Dishevelled 3 (Dvl3) regulates ectoplasmic specialization (ES) dynamics in the testis through changes in cytoskeletal organization. Cell Death Dis. 2019;10:194 pubmed publisher
    ..analysis, and with the technique of RNA interference (RNAi) to knockdown PCP protein Dishevelled (Dvl) 1 (Dvl1), Dvl2, Dvl3, or Dvl1/2/3, Dvl proteins, in particular Dvl3, it was shown that Dvl3 played a crucial role of support ..
  14. Zhao Z, Herman J, Brock M, Sheng J, Zhang M, Liu B, et al. Methylation of DACT2 promotes papillary thyroid cancer metastasis by activating Wnt signaling. PLoS ONE. 2014;9:e112336 pubmed publisher
    ..The activity of TCF/LEF was increased by co-transfecting DACT2 and Dvl2 in wild-type or mutant β-catenin cells...
  15. Zhang K, Zhang Y, Gu L, Lan M, Liu C, Wang M, et al. Islr regulates canonical Wnt signaling-mediated skeletal muscle regeneration by stabilizing Dishevelled-2 and preventing autophagy. Nat Commun. 2018;9:5129 pubmed publisher
    ..Islr interacts with Dishevelled-2 (Dvl2) to activate canonical Wnt signaling, consequently regulating the myogenic factor myogenin (MyoG)...
  16. Tadjuidje E, Cha S, Louza M, Wylie C, Heasman J. The functions of maternal Dishevelled 2 and 3 in the early Xenopus embryo. Dev Dyn. 2011;240:1727-36 pubmed publisher
    Of the three Dishevelled (Dvl) genes, only Dvl2 and Dvl3 are maternally encoded in the frog, Xenopus laevis...
  17. Smietana K, Mateja A, Krezel A, Otlewski J. PDZ domain from Dishevelled -- a specificity study. Acta Biochim Pol. 2011;58:243-9 pubmed
  18. Monies D, Abouelhoda M, AlSayed M, Alhassnan Z, Alotaibi M, Kayyali H, et al. The landscape of genetic diseases in Saudi Arabia based on the first 1000 diagnostic panels and exomes. Hum Genet. 2017;136:921-939 pubmed publisher
    ..ASB3, ATXN1L, C17orf62, CABP1, CCDC186, CCP110, CLSTN2, CNTN3, CNTN5, CTNNA2, CWC22, DMAP1, DMKN, DMXL1, DSCAM, DVL2, ECI1, EP400, EPB41L5, FBXL22, GAP43, GEMIN7, GIT1, GRIK4, GRSF1, GTRP1, HID1, IFNL1, KCNC4, LRRC52, MAP7D3, MCTP2, ..
  19. Liu X, Gao Y, Zhu C, Qi K, Xu X, Zhao D. [Effect of Dishevelled 2 on apoptosis in rheumatoid arthritis fibroblast-like synoviocytes through inhibiting JAK-STAT pathway]. Zhonghua Yi Xue Za Zhi. 2018;98:1189-1193 pubmed publisher
    b>Objective: To investigate if Dishevelled 2 (DVL2) regulates the apoptosis of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS) via the JAK-STAT pathway...
  20. Luo X, Ye S, Jiang Q, Gong Y, Yuan Y, Hu X, et al. Wnt inhibitory factor-1-mediated autophagy inhibits Wnt/β-catenin signaling by downregulating dishevelled-2 expression in non-small cell lung cancer cells. Int J Oncol. 2018;53:904-914 pubmed publisher
    ..autophagy was demonstrated to inhibit Wnt/β‑catenin signaling by downregulating dishevelled‑2 (Dvl2), which contributed to the inhibition of the proliferation and the promotion of the apoptosis of NSCLC cells...
  21. Zhang C, Li C, Chen X, Zhou Y, Yin B, Ni R, et al. Overexpression of dishevelled 2 is involved in tumor metastasis and is associated with poor prognosis in hepatocellular carcinoma. Clin Transl Oncol. 2017;19:1507-1517 pubmed publisher
    ..Dishevelled 2 (Dvl2) is one of the downstream targets of non-canonical Wnt signaling, which has been demonstrated to be of great ..
  22. Liu X, Gao Y, Qi K, Zhao D. [Expression of dishevelled-2 in cartilage of rheumatoid arthritis and its effect on cartilage destruction]. Zhonghua Nei Ke Za Zhi. 2018;57:674-678 pubmed publisher
    b>Objective: To study the expression of dishevelled-2 (DVL2) in rheumatoid arthritis cartilage and its effect on cartilage destruction...
  23. Wang J, Ren X, Piao H, Zhao S, Osada T, Premont R, et al. Niclosamide-induced Wnt signaling inhibition in colorectal cancer is mediated by autophagy. Biochem J. 2019;476:535-546 pubmed publisher
  24. Shi Z, Deng J, Fu S, Wang L, Wang Q, Liu B, et al. Protective effect of autophagy in neural ischemia and hypoxia: Negative regulation of the Wnt/β-catenin pathway. Int J Mol Med. 2017;40:1699-1708 pubmed publisher
    ..In addition, the upstream proteins (Wnt1 and Wnt3a), downstream proteins (Dvl2, β-catenin) and target proteins (C-myc and cyclin D) in the Wnt/β-catenin signaling pathway were examined ..
  25. Mazemondet O, Hübner R, Frahm J, Koczan D, Bader B, Weiss D, et al. Quantitative and kinetic profile of Wnt/β-catenin signaling components during human neural progenitor cell differentiation. Cell Mol Biol Lett. 2011;16:515-38 pubmed publisher
    ..During the first three hours of differentiation the signaling molecules LRP6, Dvl2 and β-catenin are spatio-temporally regulated between distinct cellular compartments...
  26. González Sancho J, Greer Y, Abrahams C, Takigawa Y, Baljinnyam B, Lee K, et al. Functional consequences of Wnt-induced dishevelled 2 phosphorylation in canonical and noncanonical Wnt signaling. J Biol Chem. 2013;288:9428-37 pubmed publisher
    ..We have previously reported that both Wnt3a and Wnt5a induce Dvl2 phosphorylation that is associated with an electrophoretic mobility shift and loss of recognition by monoclonal ..
  27. El Hage P, Petitalot A, Monsoro Burq A, Maczkowiak F, Driouch K, Formstecher E, et al. The Tumor-Suppressor WWOX and HDAC3 Inhibit the Transcriptional Activity of the β-Catenin Coactivator BCL9-2 in Breast Cancer Cells. Mol Cancer Res. 2015;13:902-12 pubmed publisher
    ..recently been shown to inhibit of the Wnt/β-catenin pathway by preventing the nuclear import of disheveled 2 (DVL2) in human breast cancer cells...
  28. Wang L, Xu M, Fu L, Chen X, Yang F. The Antihelminthic Niclosamide Inhibits Cancer Stemness, Extracellular Matrix Remodeling, and Metastasis through Dysregulation of the Nuclear ?-catenin/c-Myc axis in OSCC. Sci Rep. 2018;8:12776 pubmed publisher
    ..by targeting multiple components of this pathway, including downregulating the expression ?-catenin, Dishevelled 2 (DVL2), phosphorylated glycogen synthase kinase-3? (p-GSK3?) and Cyclin D1, in human OSCC SCC4 and SCC25 cell lines, as ..
  29. Zhang L, Luan L, Ma Y. Dishevelled‑2 modulates osteogenic differentiation of human synovial fibroblasts in osteoarthritis. Mol Med Rep. 2018;18:292-298 pubmed publisher
    ..The inactivation of Wnt3a reversed the effect of Dvl‑2 silencing. In conclusion, the results indicate that Dvl‑2 regulated osteogenic differentiation of SFBs in OA. ..
  30. Hübner M, Hinske C, Effinger D, Wu T, Thon N, Kreth F, et al. Intronic miR-744 Inhibits Glioblastoma Migration by Functionally Antagonizing Its Host Gene MAP2K4. Cancers (Basel). 2018;10: pubmed publisher
    ..Luciferase activity of 3'UTR reporter constructs revealed the pro-invasive factors TGFB1 and DVL2 as direct targets of miR-744...
  31. Varelas X, Miller B, Sopko R, Song S, Gregorieff A, Fellouse F, et al. The Hippo pathway regulates Wnt/beta-catenin signaling. Dev Cell. 2010;18:579-91 pubmed publisher
    ..These results uncover a cytoplasmic function of TAZ in regulating Wnt signaling and highlight the role of the Hippo pathway in coordinating morphogenetic signaling with growth control. ..
  32. Bouteille N, Driouch K, Hage P, Sin S, Formstecher E, Camonis J, et al. Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein. Oncogene. 2009;28:2569-80 pubmed publisher
    ..Our results indicate that WWOX is a novel inhibitor of the Wnt/beta-catenin pathway. WWOX would act, at least in part, by preventing the nuclear import of the Dvl proteins. ..
  33. Gnad T, Feoktistova M, Leverkus M, Lendeckel U, Naumann M. Helicobacter pylori-induced activation of beta-catenin involves low density lipoprotein receptor-related protein 6 and Dishevelled. Mol Cancer. 2010;9:31 pubmed publisher
    ..Further, we identified proteins of the Dvl family, namely Dvl2 and Dvl3, which are involved in LRP6 phosphorylation. H...
  34. Hegazy S, Alshareef A, Gelebart P, Anand M, Armanious H, Ingham R, et al. Disheveled proteins promote cell growth and tumorigenicity in ALK-positive anaplastic large cell lymphoma. Cell Signal. 2013;25:295-307 pubmed publisher
    ..To our knowledge, this is the first report demonstrating a physical and functional interaction between the Dvls and an oncogenic tyrosine kinase. ..
  35. Paclíková P, Bernatik O, Radaszkiewicz T, Bryja V. The N-Terminal Part of the Dishevelled DEP Domain Is Required for Wnt/β-Catenin Signaling in Mammalian Cells. Mol Cell Biol. 2017;37: pubmed publisher
    ..In this study, we took advantage of DVL knockout (DVL1/DVL2/DVL3 triple knockout) cells fully deficient in Wnt3a-induced signaling events and performed a series of rescue ..
  36. Gegg M, Böttcher A, Burtscher I, Hasenoeder S, Van Campenhout C, Aichler M, et al. Flattop regulates basal body docking and positioning in mono- and multiciliated cells. elife. 2014;3: pubmed publisher
    ..Taken together, the identification of novel BB/spindle positioning components as potential mediators of PCP signaling might have broader implications for other cell types, ciliary disease, and asymmetric cell division. ..
  37. Sharma M, Castro Piedras I, Simmons G, Pruitt K. Dishevelled: A masterful conductor of complex Wnt signals. Cell Signal. 2018;47:52-64 pubmed publisher
    ..Subsequently, the vertebrate homolog of Dishevelled genes were identified in Xenopus (Xdsh), mice (Dvl1, Dvl2, Dvl3), and in humans (DVL1, DVL2, DVL3) [5-10]...
  38. Hodges S, Reynolds C, Smith G, Jefferson T, Gao N, Morrison J, et al. Neuronal subset-specific deletion of Pten results in aberrant Wnt signaling and memory impairments. Brain Res. 2018;1699:100-106 pubmed publisher
    ..We found that deletion of Pten resulted in elevated Dvl2, Wnt5a/b, and Naked2, along with decreased GSK3β hippocampal synaptosome protein expression compared to wild type ..
  39. Greer Y, Fields A, Brown A, Rubin J. Atypical protein kinase C? is required for Wnt3a-dependent neurite outgrowth and binds to phosphorylated dishevelled 2. J Biol Chem. 2013;288:9438-46 pubmed publisher
    ..A., Uren, A., and Rubin, J. S. (2008) Mol. Cell. Biol. 28, 2368-2379). Subsequently, we observed that Dvl2/3 phosphorylation correlated with neurite outgrowth and that casein kinase 1?, one of the enzymes that mediate ..
  40. Agaram N, Sung Y, Zhang L, Chen C, Chen H, Singer S, et al. Dichotomy of Genetic Abnormalities in PEComas With Therapeutic Implications. Am J Surg Pathol. 2015;39:813-25 pubmed publisher
    ..9 (23%) TFE3 gene-rearranged tumors, with 3 cases showing an SFPQ/PSF-TFE3 fusion and 1 case showing a novel DVL2-TFE3 gene fusion...
  41. Dias C, Dietz D, Mazei Robison M, Sun H, Damez Werno D, Ferguson D, et al. Dishevelled-2 regulates cocaine-induced structural plasticity and Rac1 activity in the nucleus accumbens. Neurosci Lett. 2015;598:23-8 pubmed publisher
  42. Liu R, Cheng J, Chen Y, Wang W, Chen J, Mao G. Potential role and prognostic importance of dishevelled-2 in epithelial ovarian cancer. Int J Gynaecol Obstet. 2017;138:304-310 pubmed publisher
    To investigate the role and prognostic importance of Dvl2 in human epithelial ovarian cancer (EOC)...
  43. Wang L, Xiao Y, Tian T, Jin L, Lei Y, Finnell R, et al. Digenic variants of planar cell polarity genes in human neural tube defect patients. Mol Genet Metab. 2018;124:94-100 pubmed publisher
    ..These candidate genes were PCP genes, including VANGL1, VANGL2, CELSR1, SCRIB, DVL2, DVL3 and PTK7. Candidate variants were validated using Sanger sequencing...
  44. Dijksterhuis J, Baljinnyam B, Stanger K, Sercan H, Ji Y, Andres O, et al. Systematic mapping of WNT-FZD protein interactions reveals functional selectivity by distinct WNT-FZD pairs. J Biol Chem. 2015;290:6789-98 pubmed publisher
    ..Surprisingly, different WNT-FZD pairs showed differential effects on phosphorylation of DVL2 and DVL3, revealing a previously unappreciated DVL isoform selectivity by different WNT-FZD pairs in 32D cells...
  45. Kongkham P, Northcott P, Croul S, Smith C, Taylor M, Rutka J. The SFRP family of WNT inhibitors function as novel tumor suppressor genes epigenetically silenced in medulloblastoma. Oncogene. 2010;29:3017-24 pubmed publisher
    ..Stable SFRP1, SFRP2 and SFRP3 expression reduced phospho-DVL2 levels and hindered MB cell proliferation and colony formation in soft agar in vitro...
  46. Tsukiyama T, Fukui A, Terai S, Fujioka Y, Shinada K, Takahashi H, et al. Molecular Role of RNF43 in Canonical and Noncanonical Wnt Signaling. Mol Cell Biol. 2015;35:2007-23 pubmed publisher
    ..RNF43 is also one of the potential target genes of Wnt/β-catenin signaling. Our results reveal the molecular role of RNF43 and provide an insight into tumorigenesis. ..
  47. Mund T, Graeb M, Mieszczanek J, Gammons M, Pelham H, Bienz M. Disinhibition of the HECT E3 ubiquitin ligase WWP2 by polymerized Dishevelled. Open Biol. 2015;5:150185 pubmed publisher
    ..Here, we show that Dvl2 binds to the ubiquitin ligase WWP2 and unlocks its ligase activity from autoinhibition...
  48. Argani P, Zhong M, Reuter V, Fallon J, Epstein J, Netto G, et al. TFE3-Fusion Variant Analysis Defines Specific Clinicopathologic Associations Among Xp11 Translocation Cancers. Am J Surg Pathol. 2016;40:723-37 pubmed publisher
    ..partner was identified in 53/60 (88%) cases, including 18 SFPQ (PSF), 16 PRCC, 12 ASPSCR1 (ASPL), 6 NONO, and 1 DVL2. We provide the first morphologic description of the NONO-TFE3 RCC, which frequently demonstrates subnuclear ..
  49. Lee U, Kim S, Hwang J, Jang J, Son S, Ryoo I, et al. The Fungal Metabolite Brefeldin A Inhibits Dvl2-Plk1-Dependent Primary Cilium Disassembly. Mol Cells. 2017;40:401-409 pubmed publisher
    ..Among them, the application of KY-0120, identified as Brefeldin A, disturbed Dvl2-Plk1-mediated cilium disassembly via repression of the interaction of CK1É›-Dvl2 and the expression of Plk1 mRNA...
  50. Gao X, Yang L, Luo H, Tan F, Ma X, Lu C. A Rare Rs139365823 Polymorphism in Pre-miR-138 Is Associated with Risk of Congenital Heart Disease in a Chinese Population. DNA Cell Biol. 2018;37:109-116 pubmed publisher
    ..As TOF is caused by severe outflow tract (OFT) development and an alignment defect, we identified Dvl2, involved in OFT development, as a direct target of miR-138...
  51. Huang W, Kuo K, Adebayo B, Wang C, Chen Y, Jin K, et al. Garcinol inhibits cancer stem cell-like phenotype via suppression of the Wnt/β-catenin/STAT3 axis signalling pathway in human non-small cell lung carcinomas. J Nutr Biochem. 2018;54:140-150 pubmed publisher
    ..In the same assay, garcinol down-regulated β-catenin, Dvl2, Axin2, and cyclin D1 expressions in NSCLC-generated spheres, suggesting its ability to regulate the Wnt/β-..
  52. Tanghe G, Urwyler Rösselet C, De Groote P, Dejardin E, De Bock P, Gevaert K, et al. RIPK4 activity in keratinocytes is controlled by the SCFβ-TrCP ubiquitin ligase to maintain cortical actin organization. Cell Mol Life Sci. 2018;75:2827-2841 pubmed publisher
    ..pathways controlling keratinocyte proliferation and differentiation depend on its kinase activity leading to Dvl2, Pkp1 and IRF6 phosphorylation and NF-κB activation...
  53. Banach Orlowska M, Szymańska E, Miaczynska M. APPL1 endocytic adaptor as a fine tuner of Dvl2-induced transcription. FEBS Lett. 2015;589:532-9 pubmed publisher
    ..Here we report that APPL1 interacts with Dvl2, a protein known to activate the canonical and non-canonical Wnt pathways...
  54. Carvalho C, Vasanth S, Shinawi M, Russell C, Ramocki M, Brown C, et al. Dosage changes of a segment at 17p13.1 lead to intellectual disability and microcephaly as a result of complex genetic interaction of multiple genes. Am J Hum Genet. 2014;95:565-78 pubmed publisher
    ..in zebrafish embryos revealed a complex genetic architecture: dosage perturbation of four genes (ASGR1, ACADVL, DVL2, and GABARAP) impeded neurodevelopment and decreased dosage of the same loci caused a reduced mitotic index in ..
  55. Madrzak J, Fiedler M, Johnson C, Ewan R, Knebel A, Bienz M, et al. Ubiquitination of the Dishevelled DIX domain blocks its head-to-tail polymerization. Nat Commun. 2015;6:6718 pubmed publisher
    ..Here, we generate milligram quantities of pure human Dvl2 DIX domain mono-ubiquitinated at two lysines (K54 and K58) by genetically encoded orthogonal protection with ..
  56. Lee K, Johmura Y, Yu L, Park J, Gao Y, Bang J, et al. Identification of a novel Wnt5a-CK1?-Dvl2-Plk1-mediated primary cilia disassembly pathway. EMBO J. 2012;31:3104-17 pubmed publisher
    ..Here, we report unexpected roles of Dishevelled 2 (Dvl2) and interphase polo-like kinase 1 (Plk1) in primary cilia disassembly...
  57. McGreevy E, Vijayraghavan D, Davidson L, Hildebrand J. Shroom3 functions downstream of planar cell polarity to regulate myosin II distribution and cellular organization during neural tube closure. Biol Open. 2015;4:186-96 pubmed publisher
    ..These findings support a model in which the Shroom3 and PCP pathways interact to control CE and polarized bending of the neural plate and provide a clear illustration of the complex genetic basis of NTDs. ..
  58. Bernkopf D, Hadjihannas M, Behrens J. Negative-feedback regulation of the Wnt pathway by conductin/axin2 involves insensitivity to upstream signalling. J Cell Sci. 2015;128:33-9 pubmed publisher
    ..Conductin shows reduced binding to Dvl2 compared to axin, and degradation of β-catenin by conductin is only poorly blocked by Dvl2...
  59. Yan M, Wang X, Zhao L, Chang X, Zhou Z. [The effect of Wnt signaling pathway on paraquat induced PC12 cells damage]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2015;33:806-11 pubmed
    ..polymerase chain reaction (RT-PCR) was used to measure the mRNA expression of Wnt pathway key genes including Fzd1, Dvl2 and β-catenin and downstream genes including Bax, Bcl2, Survivin, Cyclin D1 and C-myc...
  60. Tan Z, Song L, Wu W, Zhou Y, Zhu J, Wu G, et al. TRIM14 promotes chemoresistance in gliomas by activating Wnt/β-catenin signaling via stabilizing Dvl2. Oncogene. 2018;37:5403-5415 pubmed publisher
    ..These findings demonstrated that TRIM14 stabilized dishevelled (Dvl2) and subsequently activated the canonical Wnt signaling and promoted chemoresistance...
  61. Liu X, Arnold J, Blackman M. Dehydroepiandrosterone administration or G{alpha}q overexpression induces {beta}-catenin/T-Cell factor signaling and growth via increasing association of estrogen receptor-{beta}/Dishevelled2 in androgen-independent prostate cancer cells. Endocrinology. 2010;151:1428-40 pubmed publisher
    ..now report that DHEA induces beta-CTS via increasing association of estrogen receptor (ER)-beta with Dishevelled2 (Dvl2) in AR nonresponsive human PrCa DU145 cells, a line of androgen-independent PrCa (AiPC) cells...
  62. Chen H, Liu L, Ma B, Ma T, Hou J, Xie G, et al. Protein kinase A-mediated 14-3-3 association impedes human Dapper1 to promote dishevelled degradation. J Biol Chem. 2011;286:14870-80 pubmed publisher
    ..Together, our findings establish a novel layer of regulation of Wnt signaling by PKA via the 14-3-3-Dpr1-Dvl axis. ..
  63. Semenov M, Snyder M. Human dishevelled genes constitute a DHR-containing multigene family. Genomics. 1997;42:302-10 pubmed
    ..Indirect immunofluorescence indicates that it is found throughout the cytoplasm. Our results indicate that the human dishevelled genes constitute a multigene family and that Dishevelled proteins are highly conserved among metazoans. ..
  64. Chang B, Tessneer K, McManus J, Liu X, Hahn S, Pasula S, et al. Epsin is required for Dishevelled stability and Wnt signalling activation in colon cancer development. Nat Commun. 2015;6:6380 pubmed publisher
    ..against colon cancer by significantly reducing the stability of the crucial Wnt signalling effector, dishevelled (Dvl2), and impairing Wnt signalling. Consistently, epsins and Dvl2 are correspondingly upregulated in colon cancer...
  65. Narimatsu M, Bose R, Pye M, Zhang L, Miller B, Ching P, et al. Regulation of planar cell polarity by Smurf ubiquitin ligases. Cell. 2009;137:295-307 pubmed publisher
    ..Our work thus uncovers ubiquitin ligases in a mechanistic link between noncanonical Wnt signaling and PCP/CE. ..
  66. Greco T, Sussman D, Camper S. Dishevelled-2 maps to human chromosome 17 and distal to Wnt3a and vestigial tail (vt) on mouse chromosome 11. Mamm Genome. 1996;7:475-6 pubmed
  67. Bentzinger C, von Maltzahn J, Dumont N, Stark D, Wang Y, Nhan K, et al. Wnt7a stimulates myogenic stem cell motility and engraftment resulting in improved muscle strength. J Cell Biol. 2014;205:97-111 pubmed publisher
    ..polarity and directional migration of mouse satellite cells and human myogenic progenitors through activation of Dvl2 and the small GTPase Rac1...
  68. He T, Wu D, Lin P, Wang L, Huang C, Chou M, et al. DDX3 promotes tumor invasion in colorectal cancer via the CK1ε/Dvl2 axis. Sci Rep. 2016;6:21483 pubmed publisher
    DDX3, a subunit of CK1ε, phosphorylates Dvl2 to promote β-catenin activation. Overexpression of the Dvl2 protein results in potent activation of β-catenin/TCF signaling in colorectal cancer...
  69. Gao C, Cao W, Bao L, Zuo W, Xie G, Cai T, et al. Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation. Nat Cell Biol. 2010;12:781-90 pubmed publisher
    ..Von Hippel-Lindau protein-mediated ubiquitylation is critical for the binding of Dvl2 to p62, which in turn facilitates the aggregation and the LC3-mediated autophagosome recruitment of Dvl2 under ..
  70. Gentzel M, Schille C, Rauschenberger V, Schambony A. Distinct functionality of dishevelled isoforms on Ca2+/calmodulin-dependent protein kinase 2 (CamKII) in Xenopus gastrulation. Mol Biol Cell. 2015;26:966-77 pubmed publisher
    ..Dvl1 is required for the activation of CamKII and PKC in the Wnt/Ca(2+) pathway. However, CamKII interacts with Dvl2 but not with Dvl1, and Dvl2 is necessary to mediate CamKII function downstream of Dvl1 in convergent extension ..
  71. Wang Z, Li B, Zhou L, Yu S, Su Z, Song J, et al. Prodigiosin inhibits Wnt/β-catenin signaling and exerts anticancer activity in breast cancer cells. Proc Natl Acad Sci U S A. 2016;113:13150-13155 pubmed
    ..cancer MDA-MB-231 and MDA-MB-468 cells, nanomolar concentrations of prodigiosin decreased phosphorylation of LRP6, DVL2, and GSK3β and suppressed β-catenin-stimulated Wnt target gene expression, including expression of cyclin D1...
  72. Kim S, Nie H, Nesin V, Tran U, Outeda P, Bai C, et al. The polycystin complex mediates Wnt/Ca(2+) signalling. Nat Cell Biol. 2016;18:752-764 pubmed publisher
    ..In Xenopus embryos, pkd1, Dishevelled 2 (dvl2) and wnt9a act within the same pathway to preserve normal tubulogenesis...
  73. Rharass T, Lantow M, Gbankoto A, Weiss D, Panàkovà D, Lucas S. Ascorbic acid alters cell fate commitment of human neural progenitors in a WNT/?-catenin/ROS signaling dependent manner. J Biomed Sci. 2017;24:78 pubmed publisher
    ..yield, and levels of two proteins: Nucleoredoxin (NXN) and the WNT/?-catenin signaling component Dishevelled 2 (DVL2). TUBB3 and MYC gene responses were evaluated by quantitative real-time PCR...
  74. Matsumoto S, Fumoto K, Okamoto T, Kaibuchi K, Kikuchi A. Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells. EMBO J. 2010;29:1192-204 pubmed publisher
    ..These results suggest that the functional and physical interaction of Dvl and APC is involved in Wnt5a/Fz2-dependent focal adhesion dynamics during cell migration and epithelial morphogenesis. ..
  75. Huang X, Li D, Wang Z, Huang Z, Dong X, Li C, et al. Study of MicroRNAs Targeted Dvl2 on the Osteoblasts Differentiation of Rat BMSCs in Hyperlipidemia Environment. J Cell Physiol. 2017;: pubmed publisher
    ..In our previous study, we observed a strong correlation between increased dvl2 expression and decreased new bone formation around implants in a rat hyperlipidemia implant surgery model...
  76. Mund T, Lewis M, Maslen S, Pelham H. Peptide and small molecule inhibitors of HECT-type ubiquitin ligases. Proc Natl Acad Sci U S A. 2014;111:16736-41 pubmed publisher
    ..Heclin kills HEK293 cells growing in culture, consistent with an essential role for HECT ligase activity in mammalian cells. ..
  77. Dong X, Wang Z, Wang H, Lan J. The Research of Dishevelled-2 in Dental Implant Osseointegration of Hyperlipidemic Rats. Int J Oral Maxillofac Implants. 2018;33:351–356 pubmed publisher
    To investigate the influence of dishevelled-2 (Dvl2) protein and the phosphorylation and ubiquitination of Dvl2 on dental implant osseointegration in hyperlipidemic rats...
  78. Gu X, Wang Y, Wang H, Ni Q, Zhang C, Zhu J, et al. Upregulated PFTK1 promotes tumor cell proliferation, migration, and invasion in breast cancer. Med Oncol. 2015;32:195 pubmed publisher
    ..and confirmed that cyclin B was a new interacting protein of PFTK1, and the complex might increase the amount of DVL2, which triggers Wnt/β-catenin signaling pathway...
  79. Guo C, Chen L, Li M, Hu Y, Ding W, Wang X. Long non-coding RNA MALAT1 regulates ovarian cancer cell proliferation, migration and apoptosis through Wnt/?-catenin signaling pathway. Eur Rev Med Pharmacol Sci. 2018;22:3703-3712 pubmed publisher
    ..The cell cycle distribution and apoptosis rate were measured by flow cytometry analysis. The expression level of Dvl2, GSK-3?, ?-catenin and cyclin D1 were detected by RT-PCR and Western blot...
  80. Sheng X, Liu Y, Wang J, Li X, Shu B. [HUVECs respond to low shear stress stimulation by activating Wnt/?-catenin signaling pathway]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017;33:1657-1661 pubmed
    ..Subsequently, real-time quantitative PCR was used to observe the mRNA expression levels of dishevelled 2 (Dvl2) and ?-catenin in the Wnt signaling pathway, and immunofluorescence technology to observe their protein expression ..
  81. Huang X, McGann J, Liu B, Hannoush R, Lill J, Pham V, et al. Phosphorylation of Dishevelled by protein kinase RIPK4 regulates Wnt signaling. Science. 2013;339:1441-5 pubmed publisher
    ..RIPK4 interacted constitutively with the adaptor protein DVL2 and, after Wnt3a stimulation, with the co-receptor LRP6...
  82. Lin Z, Gao C, Ning Y, He X, Wu W, Chen Y. The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling. J Biol Chem. 2008;283:33053-8 pubmed publisher
    ..Altogether, our data indicate that BAMBI can function as a positive regulator of the Wnt/beta-catenin pathway to promote cell proliferation. ..
  83. Liu X, Fan J, Qi K, Liu S, Xu W, Gao Y, et al. Dishevelled2 promotes apoptosis and inhibits inflammatory cytokine secretion in rheumatoid arthritis fibroblast-like synoviocytes through crosstalk with the NF-?B pathway. Oncotarget. 2017;8:12649-12663 pubmed publisher
    ..As there is no systematic study to date on Dvl in rheumatoid arthritis (RA), we explored the impact of Dvl2 on proliferation and inflammatory cytokine secretion in RA fibroblast-like synoviocytes (FLSs)...
  84. Torban E, Wang H, Groulx N, Gros P. Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family. J Biol Chem. 2004;279:52703-13 pubmed
    ..mutations identified in two independent Lp alleles associated with neural tube defects impair binding to Dvl1, Dvl2, and Dvl3. These findings suggest a molecular mechanism for the neural tube defect seen in Lp mice...
  85. Zhang X, Ke X, Pu Q, Yuan Y, Yang W, Luo X, et al. MicroRNA-410 acts as oncogene in NSCLC through downregulating SLC34A2 via activating Wnt/β-catenin pathway. Oncotarget. 2016;7:14569-85 pubmed publisher
    ..MiR-410 significantly increased the expression of DVL2 and β-catenin protein while decreased that of Gsk3β protein of Wnt/β-catenin signaling pathway, while ..
  86. Nagy I, Xu Q, Naillat F, Ali N, Miinalainen I, Samoylenko A, et al. Impairment of Wnt11 function leads to kidney tubular abnormalities and secondary glomerular cystogenesis. BMC Dev Biol. 2016;16:30 pubmed publisher
    ..Also Dvl2, an important PCP pathway component, was downregulated by more than 90 % due to Wnt11 deficiency in both the E16...
  87. Johansen T, Birgisdottir A, Huber J, Kniss A, Dotsch V, Kirkin V, et al. Methods for Studying Interactions Between Atg8/LC3/GABARAP and LIR-Containing Proteins. Methods Enzymol. 2017;587:143-169 pubmed publisher
    ..g., ULK1, ATG13, FIP200, and Dvl2), which mediate binding to Atg8/LC3/GABARAPs...
  88. Klingensmith J, Yang Y, Axelrod J, Beier D, Perrimon N, Sussman D. Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2. Mech Dev. 1996;58:15-26 pubmed
    ..We report here the isolation of a second mouse dsh homolog, Dvl2, which maps to chromosome 11...
  89. Ulmer B, Tingler M, Kurz S, Maerker M, Andre P, Mönch D, et al. A novel role of the organizer gene Goosecoid as an inhibitor of Wnt/PCP-mediated convergent extension in Xenopus and mouse. Sci Rep. 2017;7:43010 pubmed publisher
    ..b>Dvl2 recruitment to the cell membrane was inhibited by Gsc in Xenopus animal cap assays and key Wnt/PCP factors (RhoA, ..
  90. Zheng C, Yinghao S, Li J. MiR-221 expression affects invasion potential of human prostate carcinoma cell lines by targeting DVL2. Med Oncol. 2012;29:815-22 pubmed publisher
    ..Cell growth was assessed by using the CCK-8 cell proliferation assay at different times. The expression of NSE and DVL2 during the neuroendocrine phenotype and migration were measured by qRT-PCR and Western blot...
  91. De Marco P, Merello E, Consales A, Piatelli G, Cama A, Kibar Z, et al. Genetic analysis of disheveled 2 and disheveled 3 in human neural tube defects. J Mol Neurosci. 2013;49:582-8 pubmed publisher
    ..In mouse disruption of Dvl2 alone (Dvl2 (-/-)) or Dvl2 and Dvl3 (Dvl2 (-/-); Dvl3 (+/-), Dvl2 ..
  92. Rao C, Lin S, Ruan W, Wen H, Wu D, Deng H. High expression of IGFBP7 in fibroblasts induced by colorectal cancer cells is co-regulated by TGF-? and Wnt signaling in a Smad2/3-Dvl2/3-dependent manner. PLoS ONE. 2014;9:e85340 pubmed publisher
    ..The Wnt signaling-targeted genes, c-Myc, CCND1 and the proteins Dvl2/3, were all up-regulated in fibroblasts expressing high levels of IGFBP7, and the up-regulation could be inhibited ..