DVL1

Summary

Gene Symbol: DVL1
Description: dishevelled segment polarity protein 1
Alias: DRS2, DVL, DVL1L1, DVL1P1, segment polarity protein dishevelled homolog DVL-1, DSH homolog 1, dishevelled 1 (homologous to Drosophila dsh), dishevelled, dsh homolog 1, dishevelled-1
Species: human
Products:     DVL1

Top Publications

  1. Li L, Yuan H, Weaver C, Mao J, Farr G, Sussman D, et al. Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1. EMBO J. 1999;18:4233-40 pubmed
    Wnt proteins transduce their signals through dishevelled (Dvl) proteins to inhibit glycogen synthase kinase 3beta (GSK), leading to the accumulation of cytosolic beta-catenin and activation of TCF/LEF-1 transcription factors...
  2. Habas R, Kato Y, He X. Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1. Cell. 2001;107:843-54 pubmed
    ..Wnt/Fz activation of Rho requires the cytoplasmic protein Dishevelled (Dvl) and a novel Formin homology protein Daam1...
  3. Russ C, Lovestone S, Powell J. Identification of genomic organisation, sequence variants and analysis of the role of the human dishevelled 1 gene in late onset Alzheimer's disease. Mol Psychiatry. 2002;7:104-9 pubmed
    ..b>Dishevelled 1 (DVL1) is thought to act as a positive regulator of the wnt signalling pathway, and inhibits GSK3beta activity ..
  4. Gan X, Wang J, Xi Y, Wu Z, Li Y, Li L. Nuclear Dvl, c-Jun, beta-catenin, and TCF form a complex leading to stabilization of beta-catenin-TCF interaction. J Cell Biol. 2008;180:1087-100 pubmed publisher
    In canonical Wnt signaling, Dishevelled (Dvl) is a critical cytoplasmic regulator that releases beta-catenin from degradation...
  5. Lee H, Finkelstein D, Li X, Wu D, Shi D, Zheng J. Identification of transmembrane protein 88 (TMEM88) as a dishevelled-binding protein. J Biol Chem. 2010;285:41549-56 pubmed publisher
    ..Dishevelled (Dvl/Dsh) protein is one of key components in Wnt signaling and plays essential roles in regulating these pathways ..
  6. Steitz S, Tsang M, Sussman D. Wnt-mediated relocalization of dishevelled proteins. In Vitro Cell Dev Biol Anim. 1996;32:441-5 pubmed
    ..1995). We report here that the mouse Dishevelled-1 (Dvl-1) and Dishevelled-2 genes encode proteins that are differentially localized in Wnt-overexpressing PC12 cell lines (..
  7. Ikeda S, Kishida S, Yamamoto H, Murai H, Koyama S, Kikuchi A. Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin. EMBO J. 1998;17:1371-84 pubmed
    ..These results suggest that rAxin negatively regulates the Wnt signaling pathway by interacting with GSK-3beta and beta-catenin and mediating the signal from GSK-3beta to beta-catenin. ..
  8. Habas R, Dawid I, He X. Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation. Genes Dev. 2003;17:295-309 pubmed
    ..Dishevelled (Dvl), a cytoplasmic protein downstream of Fz, forms a Wnt-induced complex with Rac independent of the Wnt-induced Dvl-..
  9. Nagahata T, Shimada T, Harada A, Nagai H, Onda M, Yokoyama S, et al. Amplification, up-regulation and over-expression of DVL-1, the human counterpart of the Drosophila disheveled gene, in primary breast cancers. Cancer Sci. 2003;94:515-8 pubmed
    ..Through several cytoplasmic relay components including DVL-1, the human counterpart of the Drosophila disheveled gene, the signal is transduced to beta-catenin, which then ..

More Information

Publications125 found, 100 shown here

  1. Okino K, Nagai H, Hatta M, Nagahata T, Yoneyama K, Ohta Y, et al. Up-regulation and overproduction of DVL-1, the human counterpart of the Drosophila dishevelled gene, in cervical squamous cell carcinoma. Oncol Rep. 2003;10:1219-23 pubmed
    The Dvl-1 gene on chromosome 1p36 belongs to a family of highly conserved secreted proteins which regulates embryonic induction, generation of cell polarity and specification of cell fate through activation of Wnt signaling pathways...
  2. Wei Q, Zhao Y, Yang Z, Dong Q, Dong X, Han Y, et al. Dishevelled family proteins are expressed in non-small cell lung cancer and function differentially on tumor progression. Lung Cancer. 2008;62:181-92 pubmed publisher
    Dishevelled (Dvl) family proteins are cytoplasmic mediators of the Wnt/beta-catenin signaling pathway and have recently been linked to cancers...
  3. Tu H, Chen Y, Fu E, Shen E, Wu M, Chen Y, et al. Cyclosporine A enhances gingival β-catenin stability via Wnt signaling. J Periodontol. 2015;86:473-82 pubmed publisher
    ..examine the mRNA and protein expression of proliferating cell nuclear antigen, cyclin D1, E-cadherin, β-catenin, Dvl-1, glycogen synthase kinase-3β, axin-1, and adenomatous polyposis coli (APC)...
  4. Hedman A, Zilmer M, Sundstrom J, Lind L, Ingelsson E. DNA methylation patterns associated with oxidative stress in an ageing population. BMC Med Genomics. 2016;9:72 pubmed
    ..Methylation variation at CpGs in the 3'-UTR of HIST1H4D (cg08170869; histone cluster 1, H4d) and in the body of DVL1 (cg03465880; dishevelled-1) were associated with incident T2D events during 10 years of follow-up (all permutation ..
  5. Arellanes Robledo J, Reyes Gordillo K, Shah R, Domínguez Rosales J, Hernández Nazara Z, Ramirez F, et al. Fibrogenic actions of acetaldehyde are ?-catenin dependent but Wingless independent: a critical role of nucleoredoxin and reactive oxygen species in human hepatic stellate cells. Free Radic Biol Med. 2013;65:1487-1496 pubmed publisher
    ..001) in glutathione levels with a concomitant 76% (P<0.001) decrease in the level of NXN/ disheveled (DVL) complex...
  6. Kriz V, Korinek V. Wnt, RSPO and Hippo Signalling in the Intestine and Intestinal Stem Cells. Genes (Basel). 2018;9: pubmed publisher
    ..Interestingly, dishevelled (DVL) appears to be an important mediator involved in both Wnt and Hippo (YAP1/TAZ) signalling and some of the DVL ..
  7. Koh C, Bezzi M, Low D, Ang W, Teo S, Gay F, et al. MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis. Nature. 2015;523:96-100 pubmed publisher
    ..sensitive to the perturbation of the MYC-PRMT5 axis, resulting in either intron retention (for example, Dvl1) or exon skipping (for example, Atr, Ep400)...
  8. Wang Z, Li B, Zhou L, Yu S, Su Z, Song J, et al. Prodigiosin inhibits Wnt/β-catenin signaling and exerts anticancer activity in breast cancer cells. Proc Natl Acad Sci U S A. 2016;113:13150-13155 pubmed
    ..sites of this pathway, including the low-density lipoprotein-receptor-related protein (LRP) 6, Dishevelled (DVL), and glycogen synthase kinase-3β (GSK3β)...
  9. Clemente Napimoga J, Silva M, Peres S, Lopes A, Lossio C, Oliveira M, et al. Dioclea violacea lectin ameliorates inflammation in the temporomandibular joint of rats by suppressing intercellular adhesion molecule-1 expression. Biochimie. 2019;158:34-42 pubmed publisher
    ..This study demonstrated by molecular docking and MM/PBSA that the lectin from Dioclea violacea (DVL) interacts favorably with α-methyl-D-mannoside, N-acetyl-D-glucosamine, and core1-sialyl-Lewis X which are ..
  10. Găman A, Ungureanu A, Turculeanu A, Gheonea D, Drocaş A, Mitroi G, et al. The impact of liver steatosis on early and sustained treatment response in chronic hepatitis C patients. Rom J Morphol Embryol. 2017;58:107-113 pubmed
    ..Based on the obtained results, it appears that initial value of HCV-RNA, dVL parameter value (low relative percentage of viral load during the first 12 weeks of treatment), histological scores ..
  11. Yeh C, Fan Y, Jiang L, Yang Y, He B, You L, et al. Genistein Suppresses Growth of Human Uterine Sarcoma Cell Lines via Multiple Mechanisms. Anticancer Res. 2015;35:3167-73 pubmed
    ..Dickkopf-related protein 1 (DKK1) and suppression of histone deacetylase 4/5/7 (HDAC4/5/7), dishevelled protein (DVL), BAX, survivin and phosphorylated mitogen-activated protein kinase kinase (phospho-MEK) in all three lines; ..
  12. Banerjee P, Dutta S, Pal R. Dysregulation of Wnt-Signaling and a Candidate Set of miRNAs Underlie the Effect of Metformin on Neural Crest Cell Development. Stem Cells. 2016;34:334-45 pubmed publisher
    ..We then revealed that metformin impedes Wnt axis, a major signaling pathway active during NC formation via DVL-3 inhibition and impairment in nuclear translocation of β-catenin...
  13. Vitorino M, Silva A, Inácio J, Ramalho J, Gur M, Fainsod A, et al. Xenopus Pkdcc1 and Pkdcc2 Are Two New Tyrosine Kinases Involved in the Regulation of JNK Dependent Wnt/PCP Signaling Pathway. PLoS ONE. 2015;10:e0135504 pubmed publisher
    ..Our results showed that Pkdcc1 and Pkdcc2 promote the recruitment of Dvl to the plasma membrane...
  14. Lu D, Bao D, Dong W, Liu N, Zhang X, Gao S, et al. Dkk3 prevents familial dilated cardiomyopathy development through Wnt pathway. Lab Invest. 2016;96:239-48 pubmed publisher
    ..Furthermore, we determined that Dkk3 upregulated Dvl1 (Dishevelled 1) and key proteins of the canonical Wnt pathway (cytoplasmic and nuclear β-catenin, c-Myc, and Axin2) and ..
  15. Yuan W, Li Z, Zhao C, Hou T, Hu S, Liu W, et al. Attenuation of the degenerative effects of endothelin-1 on cartilaginous end plate cells by the endothelin receptor antagonist BQ-123 via the Wnt/β-catenin signaling pathway. Spine J. 2018;18:1669-1677 pubmed publisher
    ..In addition, ET-1 stimulation increased the expression of β-catenin, cyclin D1, and Dvl1 in the Wnt/β-catenin signaling pathway of CECs from degenerated discs and reduced the expression of GSK-3β, ..
  16. Song J, Xie C, Jiang L, Wu G, Zhu J, Zhang S, et al. Transcription factor AP-4 promotes tumorigenic capability and activates the Wnt/?-catenin pathway in hepatocellular carcinoma. Theranostics. 2018;8:3571-3583 pubmed publisher
    ..TFAP4 played an important role in activating Wnt/?-catenin signaling by directly binding to the promoters of DVL1 (dishevelled segment polarity protein 1) and LEF1 (lymphoid enhancer binding factor 1)...
  17. Yang T, Kersigo J, Wu S, Fritzsch B, Bassuk A. Prickle1 regulates neurite outgrowth of apical spiral ganglion neurons but not hair cell polarity in the murine cochlea. PLoS ONE. 2017;12:e0183773 pubmed publisher
    ..This organization is regulated by planar cell polarity (PCP) signaling. Mutations of PCP genes, such as Vangl2, Dvl1/2, Celsr1, and Fzd3/6, affect the formation of HC orientation to varying degrees...
  18. Mansour T, Lucot K, Konopelski S, Dickinson P, Sturges B, Vernau K, et al. Whole genome variant association across 100 dogs identifies a frame shift mutation in DISHEVELLED 2 which contributes to Robinow-like syndrome in Bulldogs and related screw tail dog breeds. PLoS Genet. 2018;14:e1007850 pubmed publisher
    ..Importantly, analogous frameshift mutations in the human DVL1 and DVL3 genes cause Robinow syndrome, a congenital disorder characterized by similar craniofacial, limb and ..
  19. Nag J, Kancharla A, Maoz M, Turm H, Agranovich D, Gupta C, et al. Low-density lipoprotein receptor-related protein 6 is a novel coreceptor of protease-activated receptor-2 in the dynamics of cancer-associated ?-catenin stabilization. Oncotarget. 2017;8:38650-38667 pubmed publisher
    ..Disheveled (DVL) is translocated to the cell nucleus through the DVL-PDZ domain...
  20. Zhang Q, Liu Y, Wang H, Ma L, Xia H, Niu J, et al. The preventive effects of taurine on neural tube defects through the Wnt/PCP-Jnk-dependent pathway. Amino Acids. 2017;49:1633-1640 pubmed publisher
    ..Immunohistochemistry and Western blot analyses were used to detect the expression of Dvl, RhoA and phosphorylated (p)-Jnk/Jnk in the embryonic neural tubes...
  21. Sedlmeier E, Brunner S, Much D, Pagel P, Ulbrich S, Meyer H, et al. Human placental transcriptome shows sexually dimorphic gene expression and responsiveness to maternal dietary n-3 long-chain polyunsaturated fatty acid intervention during pregnancy. BMC Genomics. 2014;15:941 pubmed publisher
    ..ratio upon intervention found in female offspring correlated with mRNA levels for the 'Wnt signaling' genes DVL1 and LRP6...
  22. Szwed M, Kania K, Jóźwiak Z. Toxicity of doxorubicin-transferrin conjugate is connected to the modulation of Wnt/β-catenin pathway in human leukemia cells. Leuk Res. 2015;39:1096-102 pubmed publisher
    ..demonstrate that DOX-TRF conjugate effectively reduces transcription of key genes involved in β-catenin signaling transduction trial (Wnt3a, DVL-1, FZD-3, LRP5, β-catenin, DKK2) and triggers morphology alternations of CML cells.
  23. Fu L, Wang Y, Han B, Li X, Shi X, Yin F, et al. Gene expression profiling and pathway network analysis of anti-tumor activity by Jaridon 6 in esophageal cancer. Eur J Pharmacol. 2017;815:478-486 pubmed publisher
    ..analysis demonstrated that Jaridon 6 regulated the expression of Wnt pathway proteins, including reduced levels of Dvl 2, survivin and cyclin D1, and increased levels of p-?-catenin, and AXIN2 in EC109 and EC9706 esophageal cancer ..
  24. Han Q, Lin X, Zhang X, Jiang G, Zhang Y, Miao Y, et al. WWC3 regulates the Wnt and Hippo pathways via Dishevelled proteins and large tumour suppressor 1, to suppress lung cancer invasion and metastasis. J Pathol. 2017;242:435-447 pubmed publisher
    ..Specifically, WWC3 interacts with Dishevelled (Dvl) proteins, prevents casein kinase 1ϵ from phosphorylating Dvls, and inhibits β-catenin nuclear translocation to ..
  25. Wang C, Dai J, Sun Z, Shi C, Cao H, Chen X, et al. Targeted inhibition of disheveled PDZ domain via NSC668036 depresses fibrotic process. Exp Cell Res. 2015;331:115-22 pubmed publisher
    ..In vitro study, NSC668036, a small organic inhibitor of the PDZ domain in Dvl, suppressed β-catenin-driven gene transcription and abolished TGF-β1-induced migration, expression of ..
  26. Liu Y, Huang D, Wang Z, Wu C, Zhang Z, Wang D, et al. LMO2 attenuates tumor growth by targeting the Wnt signaling pathway in breast and colorectal cancer. Sci Rep. 2016;6:36050 pubmed publisher
    ..that LMO2 participates in the regulation of canonical Wnt signaling in the cytoplasm by binding to Dishevelled-1/2 (DVL-1/2) proteins...
  27. Olivença D, Uliyakina I, Fonseca L, Amaral M, Voit E, Pinto F. A Mathematical Model of the Phosphoinositide Pathway. Sci Rep. 2018;8:3904 pubmed publisher
    ..of the enzyme phosphoinositide 4-phosphate 5-kinase I (PIP5KI) or the PI4K + PIP5KI + DVL protein complex are decreased and cause an efficacious reduction in PI(4,5)P2 levels while avoiding ..
  28. Yang W, Garrett L, Feng D, Elliott G, Liu X, Wang N, et al. Wnt-induced Vangl2 phosphorylation is dose-dependently required for planar cell polarity in mammalian development. Cell Res. 2017;27:1466-1484 pubmed publisher
    ..b>Dvl family members are also required for Wnt5a-induced Vangl2 phosphorylation by enhancing the interaction of CK1 and ..
  29. Mandal A, WAXMAN J. Retinoic acid negatively regulates dact3b expression in the hindbrain of zebrafish embryos. Gene Expr Patterns. 2014;16:122-9 pubmed publisher
    ..proteins are modulators of both canonical and non-canonical Wnt signaling via direct interactions with Dishevelled (Dvl) and Van Gogh like-2 (Vangl2)...
  30. Bryja V, Cervenka I, Cajanek L. The connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic?. Crit Rev Biochem Mol Biol. 2017;52:614-637 pubmed publisher
    ..Wnt pathway components - such as ?-catenin, Dishevelled (DVL), Lrp6, and Axin-- are often dedicated proteins that emerged in evolution together with the Wnt signaling cascade ..
  31. Owen J, Wagner D, Chen C, Petersen C, Reddien P. teashirt is required for head-versus-tail regeneration polarity in planarians. Development. 2015;142:1062-72 pubmed publisher
    ..heads in place of tails, a phenotype previously observed with RNAi of the Wnt pathway genes β-catenin-1, wnt1, Dvl-1/2 or wntless...
  32. Yu B, Kiechl S, Qi D, Wang X, Song Y, Weger S, et al. A Cytokine-Like Protein Dickkopf-Related Protein 3 Is Atheroprotective. Circulation. 2017;136:1022-1036 pubmed publisher
    ..This DKK3-induced migration activated ROR2 and DVL1, activated Rac1 GTPases, and upregulated JNK and c-jun phosphorylation in endothelial cells...
  33. Huang M, Yen L, Liu H, Liu P, Chung F, Wang T, et al. Significant overexpression of DVL1 in Taiwanese colorectal cancer patients with liver metastasis. Int J Mol Sci. 2013;14:20492-507 pubmed publisher
    ..We employed the immunohistochemistry (IHC) method with polyclonal mouse antibody against DVL1 to detect DVL1 expression in 60 CRC patients. CRC liver metastasis occurred in 19.16% (41/214) of the patients...
  34. Chen S, Zhang Q, Bai B, Ouyang S, Bao Y, Li H, et al. MARK2/Par1b Insufficiency Attenuates DVL Gene Transcription via Histone Deacetylation in Lumbosacral Spina Bifida. Mol Neurobiol. 2017;54:6304-6316 pubmed publisher
    ..In 47 cases with NTDs and 61 matched controls, in brain tissues, the DVL1/2 mRNA levels were correlated with the levels of a serine/threonine protein kinase MARK2, and in 20 cases with ..
  35. Matsumoto S, Fumoto K, Okamoto T, Kaibuchi K, Kikuchi A. Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells. EMBO J. 2010;29:1192-204 pubmed publisher
    ..This report shows that Dishevelled (Dvl) binds to adenomatous polyposis coli (APC) gene product, and this binding is enhanced by Wnt5a...
  36. Zhang T, Chen L, Li Y. AUV Underwater Positioning Algorithm Based on Interactive Assistance of SINS and LBL. Sensors (Basel). 2015;16: pubmed publisher
    ..algorithm mainly includes an optimal correlation algorithm with aided tracking of an SINS/Doppler velocity log (DVL)/magnetic compass pilot (MCP), a three-dimensional TDOA positioning algorithm of Taylor series expansion and a ..
  37. Yum M, Kang J, Lee A, Jo Y, Seo J, Kim H, et al. AIMP2 Controls Intestinal Stem Cell Compartments and Tumorigenesis by Modulating Wnt/?-Catenin Signaling. Cancer Res. 2016;76:4559-68 pubmed publisher
    ..Mechanistically, AIMP2 disrupted the interaction between AXIN and Dishevelled-1 (DVL1) to inhibit Wnt/?-catenin signaling by competing with AXIN...
  38. Arthofer E, Hot B, Petersen J, Strakova K, Jäger S, Grundmann M, et al. WNT Stimulation Dissociates a Frizzled 4 Inactive-State Complex with Gα12/13. Mol Pharmacol. 2016;90:447-59 pubmed publisher
    ..and that these inactive-state complexes are dissociated by WNTs and regulated by the phosphoprotein Dishevelled (DVL)...
  39. Fabijanovic D, Zunic I, Martic T, Skenderi F, Serman L, Vranic S. The expression of SFRP1, SFRP3, DVL1, and DVL2 proteins in testicular germ cell tumors. APMIS. 2016;124:942-949 pubmed publisher
    ..paraffin-embedded tissue samples of the primary germ cell tumors of the testis were stained against SFRP1, SFRP3, DVL1, and DVL2 proteins using immunohistochemistry...
  40. Sharma M, Castro Piedras I, Simmons G, Pruitt K. Dishevelled: A masterful conductor of complex Wnt signals. Cell Signal. 2018;47:52-64 pubmed publisher
    ..Subsequently, the vertebrate homolog of Dishevelled genes were identified in Xenopus (Xdsh), mice (Dvl1, Dvl2, Dvl3), and in humans (DVL1, DVL2, DVL3) [5-10]...
  41. Pizzuti A, Novelli G, Mari A, Ratti A, Colosimo A, Amati F, et al. Human homologue sequences to the Drosophila dishevelled segment-polarity gene are deleted in the DiGeorge syndrome. Am J Hum Genet. 1996;58:722-9 pubmed
    ..Sequences homologous to the 3' UTR of these transcripts (DVL-22) were positioned within the DGS critical region and were found to be deleted in DGS patients...
  42. Zhou F, Li F, Fang P, Dai T, Yang B, van Dam H, et al. Ubiquitin-Specific Protease 4 Antagonizes Osteoblast Differentiation Through Dishevelled. J Bone Miner Res. 2016;31:1888-1898 pubmed publisher
    ..strongly inhibit the Wnt/β-catenin signaling by removing Lysine-63 linked poly-ubiquitin chain from Dishevelled (Dvl)...
  43. Liu M, Li Y, Liu A, Li R, Su Y, Du J, et al. The exon junction complex regulates the splicing of cell polarity gene dlg1 to control Wingless signaling in development. elife. 2016;5: pubmed publisher
    ..More importantly, human orthologous Dlg protein is sufficient to promote Dvl protein stabilization and Wnt signaling activity, thus revealing a conserved regulatory mechanism of Wg/Wnt ..
  44. Velázquez D, Castañeda Patlán M, Robles Flores M. Dishevelled stability is positively regulated by PKC?-mediated phosphorylation induced by Wnt agonists. Cell Signal. 2017;35:107-117 pubmed publisher
    Dishevelled (Dvl) proteins are central mediators of both canonical and non-canonical Wnt signaling. It is well known that, upon Wnt stimulation, Dvl becomes phosphorylated...
  45. Strakova K, Matricon P, Yokota C, Arthofer E, Bernatik O, Rodriguez D, et al. The tyrosine Y2502.39 in Frizzled 4 defines a conserved motif important for structural integrity of the receptor and recruitment of Disheveled. Cell Signal. 2017;38:85-96 pubmed publisher
    ..receptors, which activate diverse intracellular signaling pathways via the phosphoprotein Disheveled (DVL) and heterotrimeric G proteins...
  46. Kim S, Lee J, Park J, Chung J. BP75, bromodomain-containing M(r) 75,000 protein, binds dishevelled-1 and enhances Wnt signaling by inactivating glycogen synthase kinase-3 beta. Cancer Res. 2003;63:4792-5 pubmed
    To identify novel regulators of Wnt signaling, we performed yeast two-hybrid analyses with Dvl-1 and identified BP75 as a candidate...
  47. Oshita A, Kishida S, Kobayashi H, Michiue T, Asahara T, Asashima M, et al. Identification and characterization of a novel Dvl-binding protein that suppresses Wnt signalling pathway. Genes Cells. 2003;8:1005-17 pubmed
    b>Dvl is a cytoplasmic protein to regulate the stability of beta-catenin in the Wnt signalling pathway. However, the molecular mechanism by which Dvl regulates the Wnt signalling pathway is not fully understood...
  48. Peghaire C, Bats M, Sewduth R, Jeanningros S, Jaspard B, Couffinhal T, et al. Fzd7 (Frizzled-7) Expressed by Endothelial Cells Controls Blood Vessel Formation Through Wnt/β-Catenin Canonical Signaling. Arterioscler Thromb Vasc Biol. 2016;36:2369-2380 pubmed
    ..We found that Dvl3 depletion in dvl1-/- mice mimicked the fzd7ECKO vascular phenotype and demonstrated that Fzd7 acted via β-..
  49. Xie J, Han M, Zhang M, Deng H, Wu W. PP5 (PPP5C) is a phosphatase of Dvl2. Sci Rep. 2018;8:2715 pubmed publisher
    Dishevelled (Dvl) family proteins are key mediators of Wnt signalling and function in both canonical and noncanonical branches. Dvl2, the most studied Dvl protein, is extensively regulated by phosphorylation...
  50. Punchihewa C, Ferreira A, Cassell R, Rodrigues P, Fujii N. Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins. Protein Sci. 2009;18:994-1002 pubmed publisher
    ..initiate signaling by binding to Frizzled (Fz) receptors, and the signal is then relayed by Disheveled (Dvl)...
  51. Schueler M, Braun D, Chandrasekar G, Gee H, Klasson T, Halbritter J, et al. DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling. Am J Hum Genet. 2015;96:81-92 pubmed publisher
    ..We show that DCDC2 interacts with DVL and DCDC2 overexpression inhibits β-catenin-dependent Wnt signaling in an effect additive to Wnt inhibitors...
  52. Lee I, Choi S, Yun J, Seo S, Choi S, Choi K, et al. Crystal structure of the PDZ domain of mouse Dishevelled 1 and its interaction with CXXC5. Biochem Biophys Res Commun. 2017;485:584-590 pubmed publisher
    ..Although solution structures of the Dvl1 PDZ domain have been reported, a high-resolution crystal structure would provide detailed sidechain information ..
  53. Yanai S, Wakayama M, Nakayama H, Shinozaki M, Tsukuma H, Tochigi N, et al. Implication of overexpression of dishevelled-associated activator of morphogenesis 1 (Daam-1) for the pathogenesis of human Idiopathic Pulmonary Arterial Hypertension (IPAH). Diagn Pathol. 2017;12:25 pubmed publisher
    ..immunohistochemical techniques to identify expression patterns of cascading proteins-namely Wnt-11, dishevelled-2 (Dvl-2), and dishevelled-associated activator of morphogenesis 1 (Daam-1)-in pulmonary arteries...
  54. White J, Mazzeu J, Coban Akdemir Z, Bayram Y, Bahrambeigi V, Hoischen A, et al. WNT Signaling Perturbations Underlie the Genetic Heterogeneity of Robinow Syndrome. Am J Hum Genet. 2018;102:27-43 pubmed publisher
    ..variants reside in genes within the noncanonical Wnt signaling pathway including ROR2, WNT5A, and more recently, DVL1 and DVL3. However, ∼70% of autosomal-dominant Robinow syndrome cases remain molecularly unsolved...
  55. Liu W, Sato A, Khadka D, Bharti R, Diaz H, Runnels L, et al. Mechanism of activation of the Formin protein Daam1. Proc Natl Acad Sci U S A. 2008;105:210-5 pubmed
    ..we report that Daam1 is not significantly activated by Rho binding but rather by its interaction with Dishevelled (Dvl)...
  56. Bian W, Miao W, He S, Wan Z, Luo Z, Yu X. A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4. Dev Neurobiol. 2015;75:805-22 pubmed publisher
    ..Interestingly, the less conserved distal PDZ binding motif of Fzd4, and not its conserved proximal Dvl-interacting PDZ motif, is required for mediating this effect...
  57. Guillabert Gourgues A, Jaspard Vinassa B, Bats M, Sewduth R, Franzl N, Peghaire C, et al. Kif26b controls endothelial cell polarity through the Dishevelled/Daam1-dependent planar cell polarity-signaling pathway. Mol Biol Cell. 2016;27:941-53 pubmed publisher
    ..The Wnt planar cell polarity (PCP) pathway, through the recruitment of Dishevelled (Dvl) and Dvl-associated activator of morphogenesis (Daam1), has been proposed to regulate cell actin cytoskeleton and ..
  58. Ara H, Takagishi M, Enomoto A, Asai M, Ushida K, Asai N, et al. Role for Daple in non-canonical Wnt signaling during gastric cancer invasion and metastasis. Cancer Sci. 2016;107:133-9 pubmed publisher
    ..However, the mechanism of this regulatory pathway has not been completely addressed. The scaffold protein Dvl is a major component of the Wnt signaling pathway...
  59. Choi J, Ma S, Kim H, Yun J, Heo J, Lee W, et al. Identification of small-molecule compounds targeting the dishevelled PDZ domain by virtual screening and binding studies. Bioorg Med Chem. 2016;24:3259-66 pubmed publisher
    The Dishevelled (Dvl) protein, which conveys signals from receptors to the downstream effectors, is a critical constituent of the Wnt/?-catenin signaling pathway...
  60. Zhao H, Han Y, Wang J, Yang L, Zheng X, Du J, et al. IQ-domain GTPase-activating protein 1 promotes the malignant phenotype of invasive ductal breast carcinoma via canonical Wnt pathway. Tumour Biol. 2017;39:1010428317705769 pubmed publisher
    ..GTPase-activating protein 1 is a scaffolding protein with multidomain which plays a role in modulating dishevelled (Dvl) nuclear translocation in canonical Wnt pathway...
  61. Tauriello D, Haegebarth A, Kuper I, Edelmann M, Henraat M, Canninga Van Dijk M, et al. Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl. Mol Cell. 2010;37:607-19 pubmed publisher
    ..Frizzled (Fz) receptor-mediated plasma membrane recruitment and activation of the cytoplasmic effector Dishevelled (Dvl)...
  62. Li J, Guo G, Li J, Hao J, Zhang J, Guo Y, et al. The expression and significance of dishevelled in human glioma. J Surg Res. 2014;192:509-14 pubmed publisher
    The proto-oncogene dishevelled (Dvl) is a critical component of the Wnt/?-catenin signaling pathway, and its elevated expression in various tumor types is associated with malignancy...
  63. Wang J, Li G, Qian G, Hua J, Wang Y. Expression analysis of eight amphioxus genes involved in the Wnt/?-catenin signaling pathway. Dongwuxue Yanjiu. 2016;37:136-43 pubmed
    ..To obtain basic data for functional analysis, we identified and isolated seven genes (Lrp5/6, Dvl, APC, CkI?, CkI?, Gsk3?, and Gro) of the Wnt/?-catenin signaling pathway from the amphioxus (Branchiostoma floridae)..
  64. Wang H, Ren Y, Hu X, Ma M, Wang X, Liang H, et al. Effect of Wnt Signaling on the Differentiation of Islet ?-Cells from Adipose-Derived Stem Cells. Biomed Res Int. 2017;2017:2501578 pubmed publisher
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    ..These results suggest that the axin-dependent phosphorylation of APC is mediated in part by CKIepsilon and is involved in the regulation of APC function. ..
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    Axin, Ccd1 (coiled-coil-DIX1), and dishevelled (Dvl or Dsh) are three known DIX domain proteins that play important roles in Wnt signaling...
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    ..sequencing in four unrelated DRS-affected individuals without coding mutations in WNT5A and found heterozygous DVL1 exon 14 mutations in three of them...
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    ..Dishevelled (Dvl) is an essential and central component in Wnt signaling, and its stability and activity is tightly regulated...
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    Expression of dishevelled-1 (DVL1) has recently been linked to cancer progression, however, its role in resistance to cancer therapy is unclear...
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    ..Inversin inhibits the canonical Wnt pathway by targeting cytoplasmic dishevelled (Dsh or Dvl1) for degradation; concomitantly, it is required for convergent extension movements in gastrulating Xenopus laevis ..