DUSP5

Summary

Gene Symbol: DUSP5
Description: dual specificity phosphatase 5
Alias: DUSP, HVH3, dual specificity protein phosphatase 5, VH1-like phosphatase 3, dual specificity protein phosphatase hVH3, serine/threonine specific protein phosphatase
Species: human
Products:     DUSP5

Top Publications

  1. Mandl M, Slack D, Keyse S. Specific inactivation and nuclear anchoring of extracellular signal-regulated kinase 2 by the inducible dual-specificity protein phosphatase DUSP5. Mol Cell Biol. 2005;25:1830-45 pubmed
    ..Here we demonstrate that DUSP5, an inducible nuclear phosphatase, interacts specifically with ERK2 via a kinase interaction motif (KIM) within ..
  2. Kovanen P, Bernard J, Al Shami A, Liu C, Bollenbacher Reilley J, Young L, et al. T-cell development and function are modulated by dual specificity phosphatase DUSP5. J Biol Chem. 2008;283:17362-9 pubmed publisher
    ..Here we have evaluated the in vivo actions of DUSP5, an extracellular signal-regulated kinase 1/2 (ERK1/2)-specific phosphatase, by generating transgenic mice ..
  3. Pramanik K, Chun C, Garnaas M, Samant G, Li K, Horswill M, et al. Dusp-5 and Snrk-1 coordinately function during vascular development and disease. Blood. 2009;113:1184-91 pubmed publisher
    ..we have identified a specific role that one member of this family of phosphatases, dual-specific phosphatase-5 (Dusp-5) plays in vascular development in vivo...
  4. Kucharska A, Rushworth L, Staples C, Morrice N, Keyse S. Regulation of the inducible nuclear dual-specificity phosphatase DUSP5 by ERK MAPK. Cell Signal. 2009;21:1794-805 pubmed publisher
    b>DUSP5 is an inducible, nuclear, dual-specificity phosphatase, which specifically interacts with and inactivates the ERK1/2 MAP kinases in mammalian cells...
  5. Nunes Xavier C, Tárrega C, Cejudo Marín R, Frijhoff J, Sandin A, Ostman A, et al. Differential up-regulation of MAP kinase phosphatases MKP3/DUSP6 and DUSP5 by Ets2 and c-Jun converge in the control of the growth arrest versus proliferation response of MCF-7 breast cancer cells to phorbol ester. J Biol Chem. 2010;285:26417-30 pubmed publisher
    ..MKP3/DUSP6 and DUSP5 MAP kinase phosphatases, two negative regulators of ERK1/2, were specifically up-regulated in MCF-7 and SKBR3 ..
  6. Caunt C, Keyse S. Dual-specificity MAP kinase phosphatases (MKPs): shaping the outcome of MAP kinase signalling. FEBS J. 2013;280:489-504 pubmed publisher
  7. Jeong D, Cho Y, Yoon T, Kim J, Ryu S, Kim S. Crystal structure of the catalytic domain of human DUSP5, a dual specificity MAP kinase protein phosphatase. Proteins. 2007;66:253-8 pubmed
  8. Izumi S, Higa Nakamine S, Nishi H, Torihara H, Uehara A, Sugahara K, et al. Phosphorylation of epidermal growth factor receptor at serine 1047 in cultured lung alveolar epithelial cells by bradykinin B2 receptor stimulation. Pulm Pharmacol Ther. 2018;48:53-61 pubmed publisher
    ..In addition, we found that BK treatment increased the mRNA level of dual specificity MAPK phosphatase 5 (DUSP5) in an ERK-dependent manner, which suggested that a negative feedback mechanism of ERK existed in the cells.
  9. Lösing P, Niturad C, Harrer M, Reckendorf C, Schätz T, Sinske D, et al. SRF modulates seizure occurrence, activity induced gene transcription and hippocampal circuit reorganization in the mouse pilocarpine epilepsy model. Mol Brain. 2017;10:30 pubmed publisher
    ..Upon SRF ablation, seizure evoked induction of dual specific phosphatases (Dusp5 and Dusp6) was reduced...

More Information

Publications125 found, 100 shown here

  1. Law N, Donaubauer E, Zeleznik A, Hunzicker Dunn M. How Protein Kinase A Activates Canonical Tyrosine Kinase Signaling Pathways To Promote Granulosa Cell Differentiation. Endocrinology. 2017;158:2043-2051 pubmed publisher
    ..For the MAPK/ERK pathway, PKA promotes inactivation of the MAPK phosphatase (MKP) dual specificity phosphatase (DUSP) MKP3/DUSP6 to permit MEK-phosphorylated ERK to accumulate downstream of the epidermal growth factor receptor...
  2. Eslamloo K, Xue X, Hall J, Smith N, Caballero Solares A, Parrish C, et al. Transcriptome profiling of antiviral immune and dietary fatty acid dependent responses of Atlantic salmon macrophage-like cells. BMC Genomics. 2017;18:706 pubmed publisher
    ..Moreover, the qPCR revealed transcripts responding early to pIC (e.g. lgp2, map3k8, socs1, dusp5 and cflar) and time-responsive transcripts (e.g. scarb1-a, csf1r, traf5a, cd80 and ctsf) in salmon MLCs...
  3. Cheng C, Liu F, Li J, Song Q. DUSP1 promotes senescence of retinoblastoma cell line SO-Rb5 cells by activating AKT signaling pathway. Eur Rev Med Pharmacol Sci. 2018;22:7628-7632 pubmed publisher
    ..DUSP1 plasmid transfection significantly enhanced DUSP expression, triggered SO-Rb5 cell senescence, and inhibited Akt signaling activation...
  4. Okuno H, Okuzono H, Hayase A, Kumagai F, Tanii S, Hino N, et al. Lipin-1 is a novel substrate of protein phosphatase PGAM5. Biochem Biophys Res Commun. 2019;509:886-891 pubmed publisher
    ..Our findings further elucidate the molecular mechanisms that regulate Lipin-1. ..
  5. Hua K, Wang M, Chen M, Wei L, Chen C, Ko C, et al. The H3K9 methyltransferase G9a is a marker of aggressive ovarian cancer that promotes peritoneal metastasis. Mol Cancer. 2014;13:189 pubmed publisher
    ..and quantitative RT-PCR analysis revealed that G9a regulates a cohort of tumor suppressor genes including CDH1, DUSP5, SPRY4, and PPP1R15A in ovarian cancer...
  6. Zhao B, Keasey S, Tropea J, Lountos G, Dyas B, Cherry S, et al. Phosphotyrosine Substrate Sequence Motifs for Dual Specificity Phosphatases. PLoS ONE. 2015;10:e0134984 pubmed publisher
    ..These newly identified DUSP substrates will be important for examining structure-activity relationships with physiologically relevant targets.
  7. Holzer M, Krähling V, Amman F, Barth E, Bernhart S, Carmelo V, et al. Differential transcriptional responses to Ebola and Marburg virus infection in bat and human cells. Sci Rep. 2016;6:34589 pubmed publisher
    ..We observed a strong induction of the JAK/STAT pathway, of several genes encoding inhibitors of MAP kinases (DUSP genes) and of PPP1R15A, which is involved in ER stress-induced cell death...
  8. Xu K, Bägli D, Egan S. NOTch just a bladder control problem. Cancer Cell. 2014;26:452-4 pubmed publisher
    ..This leads to elevated MAPK pathway activation, as direct Notch-mediated transcription of MAPK phosphatase DUSP is lost. These bladder tumors, with impaired Notch signaling, also show basal differentiation.
  9. Kashima Y, Suzuki A, Liu Y, Hosokawa M, Matsunaga H, Shirai M, et al. Combinatory use of distinct single-cell RNA-seq analytical platforms reveals the heterogeneous transcriptome response. Sci Rep. 2018;8:3482 pubmed publisher
    ..found that two distinct transcriptional modules, one associated with the Aurora kinase gene and the other with the DUSP gene, are aberrantly regulated in a minor population of cells and may thus contribute to the possible emergence of ..
  10. Sipthorp J, Lebraud H, Gilley R, Kidger A, Okkenhaug H, Saba El Leil M, et al. Visualization of Endogenous ERK1/2 in Cells with a Bioorthogonal Covalent Probe. Bioconjug Chem. 2017;28:1677-1683 pubmed publisher
    ..limitations were encountered with this approach, endogenous ERK1/2 was successfully imaged in cells, and "on-target" staining was confirmed by over-expressing DUSP5, a nuclear ERK1/2 phosphatase that anchors ERK1/2 in the nucleus.
  11. Finelli M, Murphy K, Chen L, Zou H. Differential phosphorylation of Smad1 integrates BMP and neurotrophin pathways through Erk/Dusp in axon development. Cell Rep. 2013;3:1592-606 pubmed publisher
    ..Together, the BMP and neurotrophin pathways form a tightly regulated signaling network with a balanced ratio of Erk1/2 and pErk1/2 to direct the precise connections between sensory neurons and peripheral targets. ..
  12. Harper S, Gratton H, Cornaciu I, Oberer M, Scott D, Emsley J, et al. Structure and catalytic regulatory function of ubiquitin specific protease 11 N-terminal and ubiquitin-like domains. Biochemistry. 2014;53:2966-78 pubmed publisher
    ..USP11 consists of an N-terminal "domain present in USPs" (DUSP) and "ubiquitin-like" (UBL) domain, together referred to as DU domains, and the catalytic domain harboring a second ..
  13. Stetka J, Vyhlidalova P, Lanikova L, Koralkova P, Gursky J, Hlusi A, et al. Addiction to DUSP1 protects JAK2V617F-driven polycythemia vera progenitors against inflammatory stress and DNA damage, allowing chronic proliferation. Oncogene. 2019;: pubmed publisher
    ..suppress DNA single-strand break repair genes' expression yet overexpress the dual-specificity phosphatase (DUSP) 1...
  14. Boulding T, Wu F, McCuaig R, Dunn J, Sutton C, Hardy K, et al. Differential Roles for DUSP Family Members in Epithelial-to-Mesenchymal Transition and Cancer Stem Cell Regulation in Breast Cancer. PLoS ONE. 2016;11:e0148065 pubmed publisher
    ..We show for the first time that the key chromatin-associated kinase PKC-θ directly regulates a subset of DUSP family members...
  15. Monteiro L, Forti F. Network analysis of DUSP12 partners in the nucleus under genotoxic stress. J Proteomics. 2019;: pubmed publisher
    Dual Specificity Phosphatase 12 is a member of the Atypical DUSP Protein Tyrosine Phosphatase family, meaning that it does not contain typical MAP kinase targeting motifs, while being able to dephosphorylate tyrosine and serine/threonine ..
  16. Ramkissoon A, Chaney K, Milewski D, Williams K, Williams R, Choi K, et al. Targeted Inhibition of the Dual Specificity Phosphatases DUSP1 and DUSP6 Suppress MPNST Growth via JNK. Clin Cancer Res. 2019;: pubmed publisher
    ..b>Experimental Design: We examined DUSP gene and protein expression in neurofibroma and MPNSTs...
  17. Buiga P, Elson A, Tabernero L, Schwartz J. Modelling the role of dual specificity phosphatases in herceptin resistant breast cancer cell lines. Comput Biol Chem. 2019;80:138-146 pubmed publisher
    ..We used a systems biology approach to investigate how DUSP overexpression could favour cell proliferation and to predict how this mechanism could be reversed by targeted ..
  18. Teyra J, Singer A, Schmitges F, Jaynes P, Kit Leng Lui S, Polyak M, et al. Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15. Structure. 2019;27:590-605.e5 pubmed publisher
    ..that targeted either the catalytic domain or each of three adaptor domains in USP15, including the N-terminal DUSP domain...
  19. Köröskényi K, Kiss B, Szondy Z. Adenosine A2A receptor signaling attenuates LPS-induced pro-inflammatory cytokine formation of mouse macrophages by inducing the expression of DUSP1. Biochim Biophys Acta. 2016;1863:1461-71 pubmed publisher
    ..kinases, but by regulating adenylate cyclase activity it enhanced the expression of dual specific phosphatase (DUSP)1, a negative regulator of MAP kinases...
  20. Zhang W, Zhang Y, Zhang H, Zhao Q, Liu Z, Xu Y. USP49 inhibits ischemia-reperfusion-induced cell viability suppression and apoptosis in human AC16 cardiomyocytes through DUSP1-JNK1/2 signaling. J Cell Physiol. 2019;234:6529-6538 pubmed publisher
    Dual-specificity protein phosphatases (DUSP) also known as mitogen-activated protein kinase (MAPK) phosphatases (MKPs) can dephosphorylate MAPKs, including extracellular signal-regulated kinase, c-Jun N-terminal kinase (JNK), and p38...
  21. Higa T, Takahashi H, Higa Nakamine S, Suzuki M, Yamamoto H. Up-regulation of DUSP5 and DUSP6 by gonadotropin-releasing hormone in cultured hypothalamic neurons, GT1-7 cells. Biomed Res. 2018;39:149-158 pubmed publisher
    ..These up-regulated genes included four dual-specificity MAPK phosphatases (DUSPs), DUSP1, DUSP2, DUSP5, and DUSP6...
  22. Ye P, Xiang M, Liao H, Liu J, Luo H, Wang Y, et al. Dual-Specificity Phosphatase 9 Protects Against Nonalcoholic Fatty Liver Disease in Mice Through ASK1 Suppression. Hepatology. 2019;69:76-93 pubmed publisher
    ..Dual-specificity phosphatase 9 (Dusp9) is a member of the DUSP protein family...
  23. Aurtenetxe O, Zaldumbide L, Erramuzpe A, Lopez R, Lopez J, Cortés J, et al. DUSP5 expression associates with poor prognosis in human neuroblastoma. Exp Mol Pathol. 2018;105:272-278 pubmed publisher
    ..pERK1/2 high expression correlated with high expression of the MKP DUSP5 in NB tumors, and was associated with poor prognosis...
  24. Song Z, Wei D, Chen Y, Chen L, Bian Y, Shen Y, et al. Association of astragaloside IV-inhibited autophagy and mineralization in vascular smooth muscle cells with lncRNA H19 and DUSP5-mediated ERK signaling. Toxicol Appl Pharmacol. 2018;364:45-54 pubmed publisher
    ..AS-IV administration attenuated the autophagy and mineralization in VSMCs. Reverse expression profiles of H19 and DUSP5 were observed...
  25. Aoki M, Matsumoto N, Okubo Y, Ogawa R. Cytochrome P450 genes play central roles in transcriptional response by keratinocytes to a high-voltage alternating current electric field. Bioelectrochemistry. 2019;126:163-171 pubmed publisher
    ..They included the cytochrome P450 (CYP) genes CYP1A1 and CYP1B1, HMOX1, EREG, DUSP5, and SLC7A11 (all upregulated), and DOCK8, ABCC6, and CYP26A1 (all downregulated)...
  26. Kleber A, Ruf C, Wolf A, Fink T, Glas M, Wolf B, et al. Melatonin or ramelteon therapy differentially affects hepatic gene expression profiles after haemorrhagic shock in rat--A microarray analysis. Exp Mol Pathol. 2015;99:189-97 pubmed publisher
    ..Shock-induced upregulation of three candidate genes with relevant functions for hepatocytes (ppp1r15a, dusp5, rhoB) was significantly reduced by melatonin (p<0.05 vs. shock/vehicle), but not by ramelteon...
  27. Boeckx C, Op de Beeck K, Wouters A, Deschoolmeester V, Limame R, Zwaenepoel K, et al. Overcoming cetuximab resistance in HNSCC: the role of AURKB and DUSP proteins. Cancer Lett. 2014;354:365-77 pubmed publisher
    ..cells still exhibit RAS-MAPK pathway signaling contributing to drug resistance, as witnessed by low expression of DUSP5 and DUSP6, negative regulators of ERK1/2, and increased expression of AURKB, a key regulator of mitosis...
  28. Xian F, Hu X, Hu X, Chen Q, Qin J, Bie J. DUSP facilitates RPMI8226 myeloma cell aging and inhibited TLR4 expression. Eur Rev Med Pharmacol Sci. 2018;22:6030-6034 pubmed publisher
    ..Whether DUSP can regulate myeloma cell is unclear...
  29. Isikbay M, Otto K, Kregel S, Kach J, Cai Y, Vander Griend D, et al. Glucocorticoid receptor activity contributes to resistance to androgen-targeted therapy in prostate cancer. Horm Cancer. 2014;5:72-89 pubmed publisher
    ..In addition, GR activation increased prostate-specific antigen (PSA) secretion and induced SGKI and MKP1/DUSP gene expression...
  30. Golebski K, van Egmond D, de Groot E, Roschmann K, Fokkens W, van Drunen C. EGR-1 and DUSP-1 are important negative regulators of pro-allergic responses in airway epithelium. Mol Immunol. 2015;65:43-50 pubmed publisher
    ..To investigate whether a deregulated expression of EGR-1 and/or DUSP-1, two potential negative regulators of pro-inflammatory responses, could contribute to the activation of the ..
  31. Bisio A, Zámborszky J, Zaccara S, Lion M, Tebaldi T, Sharma V, et al. Cooperative interactions between p53 and NFκB enhance cell plasticity. Oncotarget. 2014;5:12111-25 pubmed
    ..Transcriptome data were confirmed for 12 of 15 selected genes and seven (PLK3, LAMP3, ETV7, UNC5B, NTN1, DUSP5, SNAI1) were synergistically up-regulated after Doxo+TNFα and dependent both on p53 and NFκB...
  32. Benavides Serrato A, Anderson L, Holmes B, Cloninger C, Artinian N, Bashir T, et al. mTORC2 modulates feedback regulation of p38 MAPK activity via DUSP10/MKP5 to confer differential responses to PP242 in glioblastoma. Genes Cancer. 2014;5:393-406 pubmed
    ..Activation of MAPK signaling leads to enhanced DUSP expression, thus establishing feedback regulation of the MAPK pathway...
  33. Piras I, Krate J, Schrauwen I, Corneveaux J, Serrano G, Sue L, et al. Whole transcriptome profiling of the human hippocampus suggests an involvement of the KIBRA rs17070145 polymorphism in differential activation of the MAPK signaling pathway. Hippocampus. 2017;27:784-793 pubmed publisher
    ..01 and Fold Change?>?|1.00|) were: RSPO4 (HP); ARC, DUSP5, DNAJB5, EGR4, PPP1R15A, WBP11P1, EGR1, GADD45B (DG); CH25H, HSPA1A, HSPA1B, TNFSF9, and NPAS4 (PC)...
  34. Qiao G, Zhang M, Li Y, Xu C, Xu D, Zhao Z, et al. Biofloc technology (BFT): An alternative aquaculture system for prevention of Cyprinid herpesvirus 2 infection in gibel carp (Carassius auratus gibelio). Fish Shellfish Immunol. 2018;83:140-147 pubmed publisher
    ..groups, including myeloid-specific- peroxidase (MPO), keratin 8 (KRT 8), dual specificity phosphatase 1 (DUSP 1), interleukin-11 (IL-11), intelectin (ITLN), purine nucleoside phosphorylase 5α (PNP 5α) and c-type lysozyme (c-..
  35. James S, Jiao H, Teh H, Takahashi H, Png C, Phoon M, et al. MAPK Phosphatase 5 Expression Induced by Influenza and Other RNA Virus Infection Negatively Regulates IRF3 Activation and Type I Interferon Response. Cell Rep. 2015;10:1722-1734 pubmed publisher
    ..we show that virus infection induces the expression of MAPK phosphatase 5 (MKP5), a dual-specificity phosphatase (DUSP), in host cells...
  36. Tjaden K, Adam C, Godfrey R, Hanley P, Pardali E, Waltenberger J. Low density lipoprotein interferes with intracellular signaling of monocytes resulting in impaired chemotaxis and enhanced chemokinesis. Int J Cardiol. 2018;255:160-165 pubmed publisher
    ..the aberrant p38 activation induced by oxLDL is due to the functional impairment of Dual Specificity Phosphatase-1 (DUSP-1)...
  37. Han W, Fu X, Xie J, Meng Z, Gu Y, Wang X, et al. MiR-26a enhances autophagy to protect against ethanol-induced acute liver injury. J Mol Med (Berl). 2015;93:1045-55 pubmed publisher
    ..We identified DUSP4 and DUSP5, two MAPKs inhibitors, as direct targets of miR-26a...
  38. Clerici M, Luna Vargas M, Faesen A, Sixma T. The DUSP-Ubl domain of USP4 enhances its catalytic efficiency by promoting ubiquitin exchange. Nat Commun. 2014;5:5399 pubmed publisher
    ..Nevertheless, it requires its N-terminal DUSP-Ubl domain to achieve full catalytic turnover...
  39. Kapoor D, Trikha D, Vijayvergiya R, Kaul D, Dhawan V. Conventional therapies fail to target inflammation and immune imbalance in subjects with stable coronary artery disease: a system-based approach. Atherosclerosis. 2014;237:623-31 pubmed publisher
    ..e. inflammation (CXCR4, CXCL2, PTGS2), immune imbalance (IL-8, IL-Iß, CCL3), and active atherosclerosis (DUSP-1, OSM, ATF3)...
  40. Wang D, Han S, Peng R, Jiao C, Wang X, Han Z, et al. DUSP28 contributes to human hepatocellular carcinoma via regulation of the p38 MAPK signaling. Int J Oncol. 2014;45:2596-604 pubmed publisher
    DUSP28, a member of the atypical dual‑specificity phosphatase (DUSP) family, is a candidate tumor-related gene in hepatocellular carcinoma (HCC) selected by genome‑wide approach, but its pathological role in HCC has not been ..
  41. Hamamura K, Nishimura A, Chen A, Takigawa S, Sudo A, Yokota H. Salubrinal acts as a Dusp2 inhibitor and suppresses inflammation in anti-collagen antibody-induced arthritis. Cell Signal. 2015;27:828-35 pubmed publisher
    ..this study, we examined the effects of salubrinal on expression of inflammation linked genes as well as a family of DUSP genes using genome-wide microarrays, qPCR, and RNA interference...
  42. Tuglu M, Bostanabad S, Ozyon G, Dalkiliç B, Gurdal H. The role of dual?specificity phosphatase 1 and protein phosphatase 1 in ?2?adrenergic receptor?mediated inhibition of extracellular signal regulated kinase 1/2 in triple negative breast cancer cell lines. Mol Med Rep. 2018;17:2033-2043 pubmed publisher
    ..2?adrenergic receptor?mediated ERK1/2 dephosphorylation by investigating the role of dual?specificity phosphatase (DUSP)1/6 and protein phosphatase (PP)1/2, which are established regulators of ERK1/2 phosphorylation, in MDA?MB?231 and ..
  43. Hou P, Li Y, Lin S, Lin S, Lee J, Lin B, et al. Hypoxia-Induced Downregulation of DUSP-2 Phosphatase Drives Colon Cancer Stemness. Cancer Res. 2017;77:4305-4316 pubmed publisher
    ..Our findings illuminate mechanisms of cancer stemness and suggest new cancer therapy regimens. Cancer Res; 77(16); 4305-16. ©2017 AACR. ..
  44. Fan F, Geurts A, Pabbidi M, Smith S, Harder D, Jacob H, et al. Zinc-finger nuclease knockout of dual-specificity protein phosphatase-5 enhances the myogenic response and autoregulation of cerebral blood flow in FHH.1BN rats. PLoS ONE. 2014;9:e112878 pubmed publisher
    ..of chromosome 1 from the Brown Norway (BN) containing 15 genes including dual-specificity protein phosphatase-5 (Dusp5) were transferred into the FHH genetic background...
  45. Podok P, Wang H, Xu L, Xu D, Lu L. Characterization of myeloid-specific peroxidase, keratin 8, and dual specificity phosphatase 1 as innate immune genes involved in the resistance of crucian carp (Carassius auratus gibelio) to Cyprinid herpesvirus 2 infection. Fish Shellfish Immunol. 2014;41:531-40 pubmed publisher
    Myeloid-specific peroxidase (MPO), keratin 8 (KRT-8), and dual specificity phosphatase 1 (DUSP-1) are believed to play essential roles in innate immunity...
  46. Ajabnoor G, Bahijri S, Shaik N, Borai A, Alamoudi A, Al Aama J, et al. Ramadan fasting in Saudi Arabia is associated with altered expression of CLOCK, DUSP and IL-1alpha genes, as well as changes in cardiometabolic risk factors. PLoS ONE. 2017;12:e0174342 pubmed publisher
  47. Holmes D, Yeh J, Yan D, Xu M, Chan A. Dusp5 negatively regulates IL-33-mediated eosinophil survival and function. EMBO J. 2015;34:218-35 pubmed publisher
    ..We demonstrate here that DUSP5 is expressed in eosinophils, is upregulated following IL-33 stimulation and regulates IL-33 signaling...
  48. Chou C, Chang Y, Korinek M, Chen Y, Yang Y, Leu S, et al. The Regulations of Deubiquitinase USP15 and Its Pathophysiological Mechanisms in Diseases. Int J Mol Sci. 2017;18: pubmed publisher
    ..to high degree of homology in an N-terminal region consisting of domains present in ubiquitin-specific proteases (DUSP) domain and ubiquitin-like (UBL) domain...
  49. Faltermann S, Grundler V, Gademann K, Pernthaler J, Fent K. Comparative effects of nodularin and microcystin-LR in zebrafish: 2. Uptake and molecular effects in eleuthero-embryos and adult liver with focus on endoplasmic reticulum stress. Aquat Toxicol. 2016;171:77-87 pubmed publisher
    ..strong transcriptional changes occurred for tumor necrosis factor alpha (tnfa) and dual specificity phosphatase 5 (dusp5), associated with mitogen activated protein kinase (MAPK) pathway...
  50. Li W, Zhao Y, Zhu G, Peng W, Zhu M, Yu X, et al. Dual specific phosphatase 12 ameliorates cardiac hypertrophy in response to pressure overload. Clin Sci (Lond). 2017;131:141-154 pubmed publisher
    ..DUSP12 is a member of the dual specific phosphatase (DUSP) family, which is characterized by its DUSP activity to dephosphorylate both tyrosine and serine/threonine residues ..
  51. Pavic K, Duan G, Köhn M. VHR/DUSP3 phosphatase: structure, function and regulation. FEBS J. 2015;282:1871-90 pubmed publisher
    Vaccinia H1-related (VHR) phosphatase, also known as dual-specificity phosphatase (DUSP) 3, is a small member of the DUSP (also called DSP) family of phosphatases...
  52. Rushworth L, Kidger A, Delavaine L, Stewart G, van Schelven S, Davidson J, et al. Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRasQ61L)-driven SerpinB2 expression. Proc Natl Acad Sci U S A. 2014;111:18267-72 pubmed publisher
    Ectopic expression of dual-specificity phosphatase 5 (DUSP5), an inducible mitogen-activated protein (MAP) kinase phosphatase, specifically inactivates and anchors extracellular signal-regulated kinase (ERK)1/2 in the nucleus...
  53. Mina M, Magi S, Jurman G, Itoh M, Kawaji H, Lassmann T, et al. Promoter-level expression clustering identifies time development of transcriptional regulatory cascades initiated by ErbB receptors in breast cancer cells. Sci Rep. 2015;5:11999 pubmed publisher
    ..Moreover, we identify a new potential regulation of DUSP5 and RARA (known to antagonize the transcriptional regulation induced by the estrogen receptors) by the activity of ..
  54. Ham J, Oh E, Kim D, Choi S. Differential expression profiles and roles of inducible DUSPs and ERK1/2-specific constitutive DUSP6 and DUSP7 in microglia. Biochem Biophys Res Commun. 2015;467:254-60 pubmed publisher
    ..LPS induced expression of DUSP1, DUSP2, and DUSP5 within 60 min, whereas DUSP4 expression was induced more slowly...
  55. Rane S, Das R, Ranganathan V, Prabhu S, Das A, Mattoo H, et al. Peripheral residence of naïve CD4 T cells induces MHC class II-dependent alterations in phenotype and function. BMC Biol. 2014;12:106 pubmed publisher
    ..CD4lo cells were smaller with higher CD5 levels and lower levels of the dual-specific phosphatase (DUSP)6-suppressing micro-RNA miR181a, and responded poorly with more Th2-skewed outcomes...
  56. Park J, Das T, Song E, Kim E. Structural basis for recruiting and shuttling of the spliceosomal deubiquitinase USP4 by SART3. Nucleic Acids Res. 2016;44:5424-37 pubmed publisher
    ..HAT) repeat domain alone and in complex with the domain present in ubiquitin-specific protease (DUSP)-ubiquitin-like (UBL) domains of ubiquitin specific protease 4 (USP4)...
  57. Kutty R, Xin G, Schauder D, Cossette S, Bordas M, Cui W, et al. Dual Specificity Phosphatase 5 Is Essential for T Cell Survival. PLoS ONE. 2016;11:e0167246 pubmed publisher
    ..The final proteins in this pathway, ERK1/2, are regulated by dual specificity phosphatase 5 (DUSP5). DUSP5 is a nuclear, inducible phosphatase with high affinity and fidelity for ERK1/2...
  58. Vattakuzhi Y, Abraham S, Freidin A, Clark A, Horwood N. Dual-specificity phosphatase 1-null mice exhibit spontaneous osteolytic disease and enhanced inflammatory osteolysis in experimental arthritis. Arthritis Rheum. 2012;64:2201-10 pubmed publisher
    ..Dual-specificity phosphatase 1 (DUSP-1) is a factor involved in the negative regulation of p38 MAPK...
  59. Vemula S, Maxwell J, Nefedov A, Wan B, Steve J, Newhard W, et al. Identification of proximal biomarkers of PKC agonism and evaluation of their role in HIV reactivation. Antiviral Res. 2017;139:161-170 pubmed publisher
    ..qPCR of RNA Seq data confirmed upregulation of 24 genes, including CD69, Egr1, Egr2, Egr3, CSF2, DUSP5, and NR4A1...
  60. Zhang Q, Harding R, Hou F, Dong A, Walker J, Bteich J, et al. Structural Basis of the Recruitment of Ubiquitin-specific Protease USP15 by Spliceosome Recycling Factor SART3. J Biol Chem. 2016;291:17283-92 pubmed publisher
    ..proteases (USPs) USP15 and USP4 belong to a subset of USPs featuring an N-terminal tandem domain in USP (DUSP) and ubiquitin-like (UBL) domain...
  61. Mo S, Liu X, Hao X, Chen W, Zhang K, Cai J, et al. EYA4 functions as tumor suppressor gene and prognostic marker in pancreatic ductal adenocarcinoma through ?-catenin/ID2 pathway. Cancer Lett. 2016;380:403-12 pubmed publisher
    ..We showed that EYA4 functioned as tumor suppressor gene in PDAC via repressing ?-catenin/ID2 activation, and was an independent prognostic factor in PDAC. ..
  62. Ponzio G, Rezzonico R, Bourget I, Allan R, Nottet N, Popa A, et al. A new long noncoding RNA (lncRNA) is induced in cutaneous squamous cell carcinoma and down-regulates several anticancer and cell differentiation genes in mouse. J Biol Chem. 2017;292:12483-12495 pubmed publisher
    ..epidermal terminal differentiation and of anticancer genes such as Cgref1, Brsk1, Basp1, Dusp5, Btg2, Anpep, Dhrs9, Stfa2, Tpm1, SerpinB2, Cpa4, Crct1..
  63. Maurer J, SAGERSTROM C. A parental requirement for dual-specificity phosphatase 6 in zebrafish. BMC Dev Biol. 2018;18:6 pubmed publisher
    ..Two members of the dual-specificity phosphatase (Dusp) family, dusp6 and dusp2, are believed to be negative regulators of the ERK pathway and are expressed in both ..
  64. Shah S, Ishinaga H, Takeuchi K. Clarithromycin inhibits TNF-α-induced MUC5AC mucin gene expression via the MKP-1-p38MAPK-dependent pathway. Int Immunopharmacol. 2017;49:60-66 pubmed publisher
    ..The dual specificity phosphatase MKP-1 (MAPK phosphatase-1), also called DUSP (dual specificity phosphatase-1), was initially identified as an in vitro ERK-specific phosphatase, but depending ..
  65. Lin K, Huang M, Cheng W, Wang S, Fang S, Tu H, et al. RNA-seq transcriptome analysis of breast cancer cell lines under shikonin treatment. Sci Rep. 2018;8:2672 pubmed publisher
    ..In particular, our results indicated that shikonin induces the expression of dual specificity phosphatase (DUSP)-1 and DUSP2 in both RNA and protein levels...
  66. Coit P, Renauer P, Jeffries M, Merrill J, McCune W, Maksimowicz McKinnon K, et al. Renal involvement in lupus is characterized by unique DNA methylation changes in naïve CD4+ T cells. J Autoimmun. 2015;61:29-35 pubmed publisher
    ..The tyrosine kinase gene TNK2 involved in cell trafficking and tissue invasion, and the phosphatase gene DUSP5 which dephosphorylates and inhibits the ERK signaling pathway, were among the most hypomethylated...
  67. Börnigen D, Tyekucheva S, Wang X, Rider J, Lee G, Mucci L, et al. Computational Reconstruction of NF?B Pathway Interaction Mechanisms during Prostate Cancer. PLoS Comput Biol. 2016;12:e1004820 pubmed publisher
    ..We identified novel roles for ATF3, CXCL2, DUSP5, JUNB, NEDD9, SELE, TRIB1, and ZFP36 in this pathway, in addition to new mechanistic interactions between these ..
  68. Buffet C, Catelli M, Hecale Perlemoine K, Bricaire L, García C, Gallet Dierick A, et al. Dual Specificity Phosphatase 5, a Specific Negative Regulator of ERK Signaling, Is Induced by Serum Response Factor and Elk-1 Transcription Factor. PLoS ONE. 2015;10:e0145484 pubmed publisher
    Serum stimulation of mammalian cells induces, via the MAPK pathway, the nuclear protein DUSP5 (dual-specificity phosphatase 5), which specifically interacts with and inactivates the ERK1/2 MAP kinases...
  69. Caunt C, Kidger A, Keyse S. Visualizing and Quantitating the Spatiotemporal Regulation of Ras/ERK Signaling by Dual-Specificity Mitogen-Activated Protein Phosphatases (MKPs). Methods Mol Biol. 2016;1447:197-215 pubmed publisher
    ..of activated (p-ERK) and total ERK in populations of mouse embryonic fibroblasts derived from mice lacking DUSP5, a nuclear ERK-specific MKP...
  70. Kaltenmeier C, Vollmer L, Vernetti L, Caprio L, Davis K, Korotchenko V, et al. A Tumor Cell-Selective Inhibitor of Mitogen-Activated Protein Kinase Phosphatases Sensitizes Breast Cancer Cells to Lymphokine-Activated Killer Cell Activity. J Pharmacol Exp Ther. 2017;361:39-50 pubmed publisher
    ..mitogen-activated protein kinase (MAPK) phosphatases [dual specificity phosphatase/MAP kinase phosphatase (DUSP-MKP)] have been hypothesized to maintain cancer cell survival by buffering excessive MAPK signaling caused by ..
  71. Tögel L, Nightingale R, Wu R, Chueh A, Al Obaidi S, Luk I, et al. DUSP5 is methylated in CIMP-high colorectal cancer but is not a major regulator of intestinal cell proliferation and tumorigenesis. Sci Rep. 2018;8:1767 pubmed publisher
    ..We have found that the nuclear ERK-selective phosphatase DUSP5 is downregulated in colorectal tumours and cell lines, as previously observed in gastric and prostate cancer...
  72. Youns M, ElKhoely A, Kamel R. The growth inhibitory effect of gambogic acid on pancreatic cancer cells. Naunyn Schmiedebergs Arch Pharmacol. 2018;391:551-560 pubmed publisher
    ..effect of gambogic acid on pancreatic cancer cells was modulated through up-regulation of DDIT3, DUSP1, and DUSP5 and down-regulation of ALDOA, TOP2A, and ATG4B...
  73. Tao H, Cao W, Yang J, Shi K, Zhou X, Liu L, et al. Long noncoding RNA H19 controls DUSP5/ERK1/2 axis in cardiac fibroblast proliferation and fibrosis. Cardiovasc Pathol. 2016;25:381-9 pubmed publisher
    Down-regulation of DUSP5 has been shown to increase cell proliferation. DUSP5 expression is regulated through epigenetic events involving LncRNA H19 human choriocarcinoma cell line...
  74. Bongard R, Lepley M, Thakur K, Talipov M, Nayak J, Lipinski R, et al. Serendipitous discovery of light-induced (In Situ) formation of an Azo-bridged dimeric sulfonated naphthol as a potent PTP1B inhibitor. BMC Biochem. 2017;18:10 pubmed publisher
    Protein tyrosine phosphatases (PTPs) like dual specificity phosphatase 5 (DUSP5) and protein tyrosine phosphatase 1B (PTP1B) are drug targets for diseases that include cancer, diabetes, and vascular disorders such as hemangiomas...
  75. Chan W, Ismail H, Mayaki D, Sanchez V, Tiedemann K, Davis E, et al. Fibulin-5 Regulates Angiopoietin-1/Tie-2 Receptor Signaling in Endothelial Cells. PLoS ONE. 2016;11:e0156994 pubmed publisher
    ..and expressions of the transcription factor early growth response 1 (EGR1) and the dual-specificity phosphatase 5 (DUSP5)...
  76. Wang J, Zhou J, Kho D, Reiners J, Wu G. Role for DUSP1 (dual-specificity protein phosphatase 1) in the regulation of autophagy. Autophagy. 2016;12:1791-1803 pubmed
    ..Here we report that DUSP1/MKP-1, the founding member of the DUSP family, plays a critical role in regulating autophagy...
  77. Ma L, Bayram Y, McLaughlin H, Cho M, Krokosky A, Turner C, et al. De novo missense variants in PPP1CB are associated with intellectual disability and congenital heart disease. Hum Genet. 2016;135:1399-1409 pubmed
    ..Our data suggest that our heterozygous de novo PPP1CB pathogenic variants are associated with syndromic intellectual disability. ..
  78. Singh G, Khanna S, Raut S, Sharma S, Sharma R, Khullar M. DUSP-1 gene expression is not regulated by promoter methylation in diabetes-associated cardiac hypertrophy. Ther Adv Cardiovasc Dis. 2017;11:147-154 pubmed publisher
    The exact mechanism causing decreased expression of the dual specific phosphatase-1 ( DUSP-1) gene in diabetes-associated cardiac hypertrophy is not known...
  79. Chandrasekar A, Aksan B, Heuvel F, Förstner P, Sinske D, Rehman R, et al. Neuroprotective effect of acute ethanol intoxication in TBI is associated to the hierarchical modulation of early transcriptional responses. Exp Neurol. 2018;302:34-45 pubmed publisher
    ..g. Gadd45b and Gadd45c). While a subset of IEGs encoding for effector proteins (such as Bdnf, InhbA and Dusp5) were downregulated by ethanol, others (such as Il-6) were unaffected...
  80. Neumann T, Span E, Kalous K, Bongard R, Gastonguay A, Lepley M, et al. Identification of inhibitors that target dual-specificity phosphatase 5 provide new insights into the binding requirements for the two phosphate pockets. BMC Biochem. 2015;16:19 pubmed publisher
    Dual-specificity phosphatase-5 (DUSP5) plays a central role in vascular development and disease. We present a p-nitrophenol phosphate (pNPP) based enzymatic assay to screen for inhibitors of the phosphatase domain of DUSP5...
  81. Garner K, Perrett R, Voliotis M, Bowsher C, Pope G, Pham T, et al. Information Transfer in Gonadotropin-releasing Hormone (GnRH) Signaling: EXTRACELLULAR SIGNAL-REGULATED KINASE (ERK)-MEDIATED FEEDBACK LOOPS CONTROL HORMONE SENSING. J Biol Chem. 2016;291:2246-59 pubmed publisher
    ..inactive ERK2) and increasing negative feedback (by Egr1-driven expression of dual-specificity phosphatase 5 (DUSP5)) both reduced information transfer from GnRHR to ERK...
  82. Johnson M, Reeder J, O CONNELL M. p38MAPK activation and DUSP10 expression in meningiomas. J Clin Neurosci. 2016;30:110-114 pubmed publisher
    ..p38MAPK is regulated, in part, by dual specificity phosphatases (DUSP) that inactivate signaling by dephosphorylation...
  83. Singh G, Raut S, Khanna S, Kumar A, Sharma S, Prasad R, et al. MicroRNA-200c modulates DUSP-1 expression in diabetes-induced cardiac hypertrophy. Mol Cell Biochem. 2017;424:1-11 pubmed publisher
    ..Dual-specific phosphatase-1 (DUSP-1) has been reported to regulate the activity of MAPKs in cardiac hypertrophy; however, the role of DUSP-1 in ..
  84. Smallie T, Ross E, Ammit A, Cunliffe H, Tang T, Rosner D, et al. Dual-Specificity Phosphatase 1 and Tristetraprolin Cooperate To Regulate Macrophage Responses to Lipopolysaccharide. J Immunol. 2015;195:277-88 pubmed publisher
    Dual-specificity phosphatase (DUSP) 1 dephosphorylates and inactivates members of the MAPK superfamily, in particular, JNKs, p38α, and p38β MAPKs...
  85. Morris D, Lei B, Longo L, Bomsztyk K, Schwinn D, Michelotti G. Temporal Dissection of Rate Limiting Transcriptional Events Using Pol II ChIP and RNA Analysis of Adrenergic Stress Gene Activation. PLoS ONE. 2015;10:e0134442 pubmed publisher
    ..Temporal analysis of Nr4a3, Dusp5 and Nfil3 shows that transcription of native IEG genes can proceed at velocities of 3...
  86. Zhang H, Zheng H, Mu W, He Z, Yang B, Ji Y, et al. DUSP16 ablation arrests the cell cycle and induces cellular senescence. FEBS J. 2015;282:4580-94 pubmed publisher
    ..Here, using short hairpin RNA-based gene knockdown, we found that several members of the DUSP family play critical roles in regulating cell proliferation...
  87. Dyszkiewicz Konwińska M, Nawrocki M, Huang Y, Bryja A, Celichowski P, Jankowski M, et al. New Gene Markers for Metabolic Processes and Homeostasis in Porcine Buccal Pouch Mucosa during Cells Long Term-Cultivation-A Primary Culture Approach. Int J Mol Sci. 2018;19: pubmed publisher
    ..In results, we observed significant up-regulation of SCARB1, PTGS2, DUSP5, ITGB3, PLK2, CCL2, TGFB1, CCL8, RFC4, LYN, ETS1, ..
  88. Tao H, Yang J, Hu W, Shi K, Deng Z, Li J. MeCP2 regulation of cardiac fibroblast proliferation and fibrosis by down-regulation of DUSP5. Int J Biol Macromol. 2016;82:68-75 pubmed publisher
    ..We report that MeCP2 modulates cardiac fibrosis via down-regulation of dual-specificity phosphatase 5 (DUSP5), a nuclear phosphatase that negatively regulates prohypertrophic signaling by ERK1/2...
  89. Kidger A, Rushworth L, Stellzig J, Davidson J, Bryant C, Bayley C, et al. Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling. Proc Natl Acad Sci U S A. 2017;114:E317-E326 pubmed publisher
    ..However, interactions between these feedback mechanisms are unclear. Here we show that, although the MKP DUSP5 both inactivates and anchors ERK in the nucleus, it paradoxically increases and prolongs cytoplasmic ERK activity...
  90. Yokoyama Y, Watanabe T, Tamura Y, Hashizume Y, Miyazono K, Ehata S. Autocrine BMP-4 Signaling Is a Therapeutic Target in Colorectal Cancer. Cancer Res. 2017;77:4026-4038 pubmed publisher
    ..of endogenous BMP signaling by the BMP type I receptor inhibitor LDN-193189 elevated expression of the phosphatase DUSP5 in colorectal cancer cells, inducing apoptosis via dephosphorylation of Erk MAPK...
  91. Talipov M, Nayak J, Lepley M, Bongard R, Sem D, Ramchandran R, et al. Critical Role of the Secondary Binding Pocket in Modulating the Enzymatic Activity of DUSP5 toward Phosphorylated ERKs. Biochemistry. 2016;55:6187-6195 pubmed
    b>DUSP5 is an inducible nuclear dual-specificity phosphatase that specifically interacts with and deactivates extracellular signal-regulated kinases ERK1 and ERK2, which are responsible for cell proliferation, differentiation, and survival...
  92. Mills B, Albert G, Halterman M. Expression Profiling of the MAP Kinase Phosphatase Family Reveals a Role for DUSP1 in the Glioblastoma Stem Cell Niche. Cancer Microenviron. 2017;10:57-68 pubmed publisher
    ..BRAin Neoplasia DaTa (REMBRANDT) revealed induction (DUSP4, DUSP6), repression (DUSP2, DUSP7-9), or mixed (DUSP1, DUSP5, DUSP10, DUSP15) DUSP transcription of select DUSPs in bulk tumor specimens...