DUSP4

Summary

Gene Symbol: DUSP4
Description: dual specificity phosphatase 4
Alias: HVH2, MKP-2, MKP2, TYP, dual specificity protein phosphatase 4, MAP kinase phosphatase 2, VH1 homologous phosphatase 2, dual specificity protein phosphatase hVH2, mitogen-activated protein kinase phosphatase 2, serine/threonine specific protein phosphatase
Species: human
Products:     DUSP4

Top Publications

  1. Cadalbert L, Sloss C, Cameron P, Plevin R. Conditional expression of MAP kinase phosphatase-2 protects against genotoxic stress-induced apoptosis by binding and selective dephosphorylation of nuclear activated c-jun N-terminal kinase. Cell Signal. 2005;17:1254-64 pubmed
    ..These studies demonstrate the in vivo specificity of MKP-2 for JNK and not ERK and show that nuclear-targeted JNK is involved in genotoxic stress-induced apoptosis. ..
  2. Guan K, Butch E. Isolation and characterization of a novel dual specific phosphatase, HVH2, which selectively dephosphorylates the mitogen-activated protein kinase. J Biol Chem. 1995;270:7197-203 pubmed
    ..Here we report the cloning and characterization of a novel dual specific phosphatase, HVH2, which may function in vivo as a MAP kinase phosphatase...
  3. Chu Y, Solski P, Khosravi Far R, Der C, Kelly K. The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation. J Biol Chem. 1996;271:6497-501 pubmed
    ..A hyperactive allele of ERK2 (D319N), analogous to the Drosophila sevenmaker gain-of-function mutation, has significantly reduced sensitivity to all three MAP kinase phosphatases in vivo. ..
  4. Chen P, Hutter D, Yang X, Gorospe M, Davis R, Liu Y. Discordance between the binding affinity of mitogen-activated protein kinase subfamily members for MAP kinase phosphatase-2 and their ability to activate the phosphatase catalytically. J Biol Chem. 2001;276:29440-9 pubmed
    ..Our studies provided a mechanistic explanation for the substrate preference of MKP-2 and suggest that catalytic activation of MKP-2 upon binding to its substrates is crucial for its function. ..
  5. Cadalbert L, Sloss C, Cunningham M, Al Mutairi M, McIntire A, Shipley J, et al. Differential regulation of MAP kinase activation by a novel splice variant of human MAP kinase phosphatase-2. Cell Signal. 2010;22:357-65 pubmed publisher
  6. Al Mutairi M, Al Harthi S, Cadalbert L, Plevin R. Over-expression of mitogen-activated protein kinase phosphatase-2 enhances adhesion molecule expression and protects against apoptosis in human endothelial cells. Br J Pharmacol. 2010;161:782-98 pubmed publisher
    ..These properties may make Adv.MKP-2 a potentially useful future therapy in cardiovascular diseases where endothelial dysfunction is a feature. ..
  7. Tresini M, Lorenzini A, Torres C, Cristofalo V. Modulation of replicative senescence of diploid human cells by nuclear ERK signaling. J Biol Chem. 2007;282:4136-51 pubmed
    ..This impairment coincides with increased activity of the nuclear ERK phosphatase MKP2. Here we show that replicative lifespan can be altered by changes in nuclear ERK activity...
  8. Amit I, Citri A, Shay T, Lu Y, Katz M, Zhang F, et al. A module of negative feedback regulators defines growth factor signaling. Nat Genet. 2007;39:503-12 pubmed
    ..More generally, our study proposes a mechanistic description of the cellular response to growth factors by defining architectural motifs that underlie the function of signaling networks. ..
  9. Wang J, Shen W, Jin Y, Brandt Rauf P, Yin Y. A molecular link between E2F-1 and the MAPK cascade. J Biol Chem. 2007;282:18521-31 pubmed
    ..E2F-1 acts as a transcriptional regulator of MKP-2 (MAPK phosphatase-2), a dual specificity protein phosphatase (DUSP4) with stringent substrate specificity for MAPKs...

More Information

Publications138 found, 100 shown here

  1. Saigusa S, Inoue Y, Tanaka K, Toiyama Y, Okugawa Y, Shimura T, et al. Decreased expression of DUSP4 is associated with liver and lung metastases in colorectal cancer. Med Oncol. 2013;30:620 pubmed publisher
    Dual-specificity protein phosphatase 4 (DUSP4), a negative regulator of extracellular-regulated kinase activity, is a potential mediator of resistance to chemotherapy and a tumor suppressor...
  2. Arvidsson G, Henriksson J, Sander B, Wright A. Mixed-species RNAseq analysis of human lymphoma cells adhering to mouse stromal cells identifies a core gene set that is also differentially expressed in the lymph node microenvironment of mantle cell lymphoma and chronic lymphocytic leukemia patient. Haematologica. 2018;103:666-678 pubmed publisher
    ..From these genes, we suggest a core set of genes (CCL3, CCL4, DUSP4, ETV5, ICAM1, IL15RA, IL21R, IL4I1, MFSD2A, NFKB1, NFKBIE, SEMA7A, TMEM2) characteristic of cells undergoing ..
  3. Checker R, Gambhir L, Sharma D, Kumar M, Sandur S. Plumbagin induces apoptosis in lymphoma cells via oxidative stress mediated glutathionylation and inhibition of mitogen-activated protein kinase phosphatases (MKP1/2). Cancer Lett. 2015;357:265-78 pubmed publisher
    ..In conclusion, oxidative stress mediated tumor cytotoxicity operates through sustained JNK activation via a novel redox-mediated regulation of MKP-1 and MKP-2. ..
  4. Plotnik J, Budka J, Ferris M, Hollenhorst P. ETS1 is a genome-wide effector of RAS/ERK signaling in epithelial cells. Nucleic Acids Res. 2014;42:11928-40 pubmed publisher
    ..cell migration genes, but also identified a surprising role for ETS1 in the repression of genes such as DUSP4, DUSP6 and SPRY4 that provide negative feedback to the RAS/ERK pathway...
  5. Westphal S, Stoppe C, Gruenewald M, Bein B, Renner J, Cremer J, et al. Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery - a sub-analysis of the RIPHeart-Study. BMC Cardiovasc Disord. 2019;19:26 pubmed publisher
    ..We identified several potential loci, in particular PHLPP2, BBS9, RyR2, DUSP4 and HSPA8, associated with new-onset of atrial fibrillation, delirium, myocardial infarction, acute kidney injury ..
  6. Röhlig M, Junemann A, Fischer D, Prakasam R, Stachs O, Schumann H. [Visual Analysis of Retinal OCT Data]. Klin Monbl Augenheilkd. 2017;234:1463-1471 pubmed publisher
    ..Wir belegen dies beispielhaft anhand einer Studie mit pädiatrischen Patienten mit Diabetes mellitus Typ 1 (T1DM)...
  7. Ilyenko I. Role of VEGF-A gene in the formation of late effects after the Chornobyl accident. Probl Radiac Med Radiobiol. 2013;:190-9 pubmed
    ..u grupi ULNA na ChAES, jaka ne povjazana z ekspresijeju VEGF-A, shho daje pidstavy oharakteryzuvaty takyj typ imunologichnogo reaguvannja jak projav viddalenyh efektiv pislja oprominennja. Vysnovky...
  8. Zeng Z, Yang Y, Dai X, Xu S, Li T, Zhang Q, et al. Polydatin ameliorates injury to the small intestine induced by hemorrhagic shock via SIRT3 activation-mediated mitochondrial protection. Expert Opin Ther Targets. 2016;20:645-52 pubmed publisher
    ..The addition of 3-TYP (SIRT3 inhibitor) partially blocked the mitochondrial-protective effects of PD, but did not affect increased SIRT1 ..
  9. Bensch W, Teske C, Hansen A, Weihrich R, Kienle L, Kamp M, et al. Synthesis, Crystal Structure and Selected Properties of [Au(S2CNH2)2]SCN: A precursor for gold macro-needles consisting of gold nanoparticles glued by graphitic carbon nitride. Chemistry. 2019;: pubmed publisher
    ..with signals corresponding well to heptazine units like in melon and triazine units like in poly(triazin imide) typ compounds are present...
  10. Ferguson B, Nam H, Stephens J, Morrison R. Mitogen-Dependent Regulation of DUSP1 Governs ERK and p38 Signaling During Early 3T3-L1 Adipocyte Differentiation. J Cell Physiol. 2016;231:1562-74 pubmed publisher
    ..of this, qRT-PCR identified several MAPK-specific DUSPs induced during early (DUSP2, -4, -5, & -6), mid (DUSP4 & -16) and late (DUSP9) stages of adipocyte differentiation...
  11. Wang W, Wang J, Li N, Zhang X, Zhao W, Li J, et al. Chemopreventive flavonoids from Millettia pulchra Kurz var-laxior (Dunn) Z.Wei (Yulangsan) function as Michael reaction acceptors. Bioorg Med Chem Lett. 2015;25:1078-81 pubmed publisher
    ..Compounds 3, 4, 6, 13, and 14 showed to have NQO1 inducing activity. Among them, compounds 4 and 14 interact with NQO1 at Gly 149, Gly 150, Phe 106, Typ 105 and His 161, revealed by molecular docking studies.
  12. Okuno H, Okuzono H, Hayase A, Kumagai F, Tanii S, Hino N, et al. Lipin-1 is a novel substrate of protein phosphatase PGAM5. Biochem Biophys Res Commun. 2019;509:886-891 pubmed publisher
    ..Our findings further elucidate the molecular mechanisms that regulate Lipin-1. ..
  13. Chen T, Sorna V, Choi S, Call L, Bearss J, Carpenter K, et al. Fragment-based design, synthesis, biological evaluation, and SAR of 1H-benzo[d]imidazol-2-yl)-1H-indazol derivatives as potent PDK1 inhibitors. Bioorg Med Chem Lett. 2017;27:5473-5480 pubmed publisher
    ..The microarray data showed that DUSP6, DUSP4, and FOSL1 were down-regulated in the sensitive cell lines with the compound treatment...
  14. Gleize V, Alentorn A, Connen de Kérillis L, Labussière M, Nadaradjane A, Mundwiller E, et al. CIC inactivating mutations identify aggressive subset of 1p19q codeleted gliomas. Ann Neurol. 2015;78:355-74 pubmed publisher
    ..glioma cell line expressing IDH1(R132H) and overexpression of CCND1 and other new target genes of CIC, such as DUSP4 and SPRED1...
  15. Ma Y, Li M. Establishment of a Strong Link Between Smoking and Cancer Pathogenesis through DNA Methylation Analysis. Sci Rep. 2017;7:1811 pubmed publisher
    ..Of these, genes such as DUSP4 and AKT3 are well documented as being involved in smoking-related lung cancer...
  16. Jäckel K, Braschler T, Knechtle B. [When the tissue tolerance fiber tears]. Praxis (Bern 1994). 2015;104:411-7 pubmed publisher
    ..axillaris-Aneurysma und einige Jahre später mit einer akuten Aortendissektion vom Typ Stanford A präsentierte...
  17. Badodi S, Dubuc A, Zhang X, Rosser G, da Cunha Jaeger M, Kameda Smith M, et al. Convergence of BMI1 and CHD7 on ERK Signaling in Medulloblastoma. Cell Rep. 2017;21:2772-2784 pubmed publisher
    ..We provide evidence that repression of the ERK inhibitor DUSP4 by BMI1 is dependent on a more accessible chromatin configuration in G4 MB cells with low CHD7 expression...
  18. Subat S, Inamura K, Ninomiya H, Nagano H, Okumura S, Ishikawa Y. Unique MicroRNA and mRNA Interactions in EGFR-Mutated Lung Adenocarcinoma. J Clin Med. 2018;7: pubmed publisher
    ..comprehensive view of the complex miRNA⁻mRNA interactions in EGFR-mutated lung adenocarcinoma, including DUSP4 and MUC4 axes...
  19. Li Z, Zhao Y, Liu X, Jiang Z, Peng J, Jin J, et al. Construction of the Leaf Senescence Database and Functional Assessment of Senescence-Associated Genes. Methods Mol Biol. 2017;1533:315-333 pubmed
    ..of putative SAGs reveal that WRKY75, AZF2, NAC16, and WRKY26 are positive regulators of leaf senescence, while MKP2 and CTR1 perform negative regulation to leaf senescence...
  20. Fernández Rozadilla C, Cazier J, Tomlinson I, Carvajal Carmona L, Palles C, Lamas M, et al. A colorectal cancer genome-wide association study in a Spanish cohort identifies two variants associated with colorectal cancer risk at 1p33 and 8p12. BMC Genomics. 2013;14:55 pubmed publisher
    ..These two SNPs are located near the SLC5A9 and DUSP4 loci, respectively, which could be good functional candidates for the association signals...
  21. Jałoszyński P. Redescription of late-instar larva of Scydmoraphes sparshalli (Denny) Coleoptera: Staphylinidae, Scydmaeninae). Zootaxa. 2015;4032:582-94 pubmed publisher
    ..study of previous descriptions resulted in recognizing a misidentification of a Scydmoraphes larva (the "Typ 2-Larve" of Schmid) as a putative Neuraphes (Pararaphes)...
  22. Ouyang J, Zeng Z, Fang H, Li F, Zhang X, Tan W. SIRT3 Inactivation Promotes Acute Kidney Injury Through Elevated Acetylation of SOD2 and p53. J Surg Res. 2019;233:221-230 pubmed publisher
    ..The rats were intraperitoneally injected with either the vehicle or a selective SIRT3 inhibitor (3-TYP) and scarified at different time points (4, 8, and 24 h after I/R)...
  23. Balakirev E, Krupnova T, Ayala F. DNA variation in the phenotypically-diverse brown alga Saccharina japonica. BMC Plant Biol. 2012;12:108 pubmed publisher
    ..and mitochondrial (COI) DNA sequence data, we have analyzed the genetic composition of typical Saccharina japonica (TYP) and its two common morphological varieties, known as the "longipes" (LON) and "shallow-water" (SHA) forms seeking ..
  24. Wierzbicka M, Leszczyńska M, Szyfter W. [Re-evaluation of 191 larynx cancer surgeries according to the Open Partial Horizontal Laryngectomies classification proposed by European Laryngological Society working committee in 2014]. Otolaryngol Pol. 2014;68:281-6 pubmed publisher
    ..There was no discrepancies in supraglottic laryngectomies (4 cases), classified as OPHL Typ I...
  25. Lim S, Pradhan A, Barth R, Nahar S, Nakkula R, Yang W, et al. Tumoricidal activity of low-energy 160-KV versus 6-MV X-rays against platinum-sensitized F98 glioma cells. J Radiat Res. 2015;56:77-89 pubmed publisher
    ..cells; and (iii) to describe the in vitro cytotoxicity and in vivo toxicity of a Pt(II) terpyridine platinum (Typ-Pt) complex...
  26. Xue Z, Vis D, Bruna A, Sustic T, van Wageningen S, Batra A, et al. MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models. Cell Res. 2018;28:719-729 pubmed publisher
    ..We show here that MEK inhibition activates JNK-JUN signaling through suppression of DUSP4, leading to activation of HER Receptor Tyrosine Kinases...
  27. Gu Y, Lv X, Liu Y, Li J, Du G, Chen J, et al. Synthetic redesign of central carbon and redox metabolism for high yield production of N-acetylglucosamine in Bacillus subtilis. Metab Eng. 2019;51:59-69 pubmed publisher
    One of the primary goals of microbial metabolic engineering is to achieve high titer, yield and productivity (TYP) of engineered strains...
  28. O Farrell H, Harbourne B, Kurlawala Z, Inoue Y, Nagelberg A, Martinez V, et al. Integrative Genomic Analyses Identifies GGA2 as a Cooperative Driver of EGFR-Mediated Lung Tumorigenesis. J Thorac Oncol. 2019;14:656-671 pubmed publisher
    ..EGFR mutation, including amplification of the mutant EGFR allele and deletion of dual specificity phosphatase 4 (DUSP4), which have both previously been reported...
  29. Overby M, Caspari S. Volubility, consonant, and syllable characteristics in infants and toddlers later diagnosed with childhood apraxia of speech: A pilot study. J Commun Disord. 2015;55:44-62 pubmed publisher
    ..syllable structure development between infants and toddlers (birth-24 months) with typical speech sound production (TYP) and those later diagnosed with childhood apraxia of speech (CAS)...
  30. Auger Messier M, Accornero F, Goonasekera S, Bueno O, Lorenz J, van Berlo J, et al. Unrestrained p38 MAPK activation in Dusp1/4 double-null mice induces cardiomyopathy. Circ Res. 2013;112:48-56 pubmed publisher
    ..To determine the role of DUSP1 and DUSP4 in regulating p38 MAPK function in the heart and the effect on disease...
  31. Cushman S, Jiang C, Hatch A, Shterev I, Sibley A, Niedzwiecki D, et al. Gene expression markers of efficacy and resistance to cetuximab treatment in metastatic colorectal cancer: results from CALGB 80203 (Alliance). Clin Cancer Res. 2015;21:1078-86 pubmed publisher
    ..gene expression levels of HER-related genes, including amphiregulin (AREG), betacellulin (BTC), NT5E (CD73), DUSP4, EGF, EGFR, epigen (EPGN), epiregulin (EREG), HBEGF, ERBB2 (HER2), ERBB3 (HER3), ERBB4 (HER4), PHLDA1, and TGFA...
  32. May T, Cornish K, Rinehart N. Exploring factors related to the anger superiority effect in children with Autism Spectrum Disorder. Brain Cogn. 2016;106:65-71 pubmed publisher
    ..were 81, 7-12year old children, 42 with ASD matched on age, gender and perceptual IQ to 39 typically developing (TYP) children...
  33. Brinkhof B, van Tol H, Groot Koerkamp M, Riemers F, IJzer S, Mashayekhi K, et al. A mRNA landscape of bovine embryos after standard and MAPK-inhibited culture conditions: a comparative analysis. BMC Genomics. 2015;16:277 pubmed publisher
    ..Expression of other genes in the MAPK pathway including DUSP4 and SPRY4, or influenced by MAPK inhibition such as IFNT, was down-regulated...
  34. Lubos E, Kelly N, Oldebeken S, Leopold J, Zhang Y, Loscalzo J, et al. Glutathione peroxidase-1 deficiency augments proinflammatory cytokine-induced redox signaling and human endothelial cell activation. J Biol Chem. 2011;286:35407-17 pubmed publisher
    ..Among the genes whose expression changed significantly, dual specificity phosphatase 4 (DUSP4), encoding an antagonist of MAPK signaling, was down-regulated by GPx-1 suppression...
  35. Braga L, Faria Silva A, Buono V, de Azevedo Bahia M. Impact of heat treatments on the fatigue resistance of different rotary nickel-titanium instruments. J Endod. 2014;40:1494-7 pubmed publisher
    ..Inc, Cuyahoga Falls, OH), ProFile Vortex (PV; Dentsply Tulsa Dental Specialties, Tulsa, OK), and Typhoon (TYP; Clinician's Choice Dental Products, New Milford, CT) systems together with ProTaper Universal F2 instruments (PTU ..
  36. Tsai M, Strong C, Lin C. Effects of pubertal timing on deviant behaviors in Taiwan: A longitudinal analysis of 7th- to 12th-grade adolescents. J Adolesc. 2015;42:87-97 pubmed publisher
    We investigated the relationship between pubertal timing and deviant behaviors in Taiwan using Taiwan Youth Project (TYP) data. The TYP used multistage-stratified and class-clustered methods in 40 randomly selected schools...
  37. Kim S, Han Y, Oh M, Kim W, Oh K, Lee S, et al. DUSP4 regulates neuronal differentiation and calcium homeostasis by modulating ERK1/2 phosphorylation. Stem Cells Dev. 2015;24:686-700 pubmed publisher
    ..In this study, we show that dual specificity phosphatase 4 (DUSP4) is crucial for neuronal differentiation and functions in the neurogenesis of embryonic stem cells (ESCs)...
  38. Han W, Fu X, Xie J, Meng Z, Gu Y, Wang X, et al. MiR-26a enhances autophagy to protect against ethanol-induced acute liver injury. J Mol Med (Berl). 2015;93:1045-55 pubmed publisher
    ..We identified DUSP4 and DUSP5, two MAPKs inhibitors, as direct targets of miR-26a...
  39. Barajas Espinosa A, Basye A, Angelos M, Chen C. Modulation of p38 kinase by DUSP4 is important in regulating cardiovascular function under oxidative stress. Free Radic Biol Med. 2015;89:170-81 pubmed publisher
    ..Previously, we demonstrated that N-acetyl cysteine (NAC) pretreatment up-regulates DUSP4 expression in endothelial cells, regulating p38 and ERK1/2 activities, and thus providing a protective effect ..
  40. Demetriou E, Song C, Park S, Pepper K, Naismith S, Hermens D, et al. Autism, Early Psychosis, and Social Anxiety Disorder: a transdiagnostic examination of executive function cognitive circuitry and contribution to disability. Transl Psychiatry. 2018;8:200 pubmed publisher
    ..ASD), Early Psychosis (EP) and Social Anxiety Disorder (SAD), as well as a neurotypically developing group (TYP). We examined whether overall disability could be predicted by neuropsychological and self-report assessments of EF...
  41. Enzensberger C, Vogel M, Degenhardt J, Fass N, Kawecki A, Kohl T, et al. Fetal pulmonary venous flow and restrictive foramen ovale in hypoplastic left heart. Ultraschall Med. 2012;33:E38-E45 pubmed publisher
    ..3 verschiedene PV-Doppler-Spektren konnten nachgewiesen werden: Typ A: kontinuierlicher Vorwärtsfluss mit einem geringen Rückwärtsfluss während der a-Welle; Typ B: ..
  42. Guan G, Zhang D, Zheng Y, Wen L, Yu D, Lu Y, et al. microRNA-423-3p promotes tumor progression via modulation of AdipoR2 in laryngeal carcinoma. Int J Clin Exp Pathol. 2014;7:5683-91 pubmed
    ..in silico prediction algorithms for target identification, AdipoR2 (adiponectin receptor 2) and DUSP4 (MAP kinase phosphatase 2) were identified to be potential targets of miR-423-3p...
  43. Zhai M, Li B, Duan W, Jing L, Zhang B, Zhang M, et al. Melatonin ameliorates myocardial ischemia reperfusion injury through SIRT3-dependent regulation of oxidative stress and apoptosis. J Pineal Res. 2017;63: pubmed publisher
    ..effects of melatonin were largely abolished by the selective SIRT3 inhibitor 3-(1H-1,2,3-triazol-4-yl)pyridine (3-TYP), suggesting that SIRT3 plays an essential role in mediating the cardioprotective effects of melatonin...
  44. Lunger A, Lunger L, Bach A, Frey C, Jandali A, Sproedt J. [Early active motion management of volar plate disruption of the proximal interphalangeal joint after finger hyperextension injury: extension block splinting versus buddy taping]. Handchir Mikrochir Plast Chir. 2017;49:297-303 pubmed publisher
    ..in unserer handchirurgischen Ambulanz wegen luxationsstabiler Läsionen der palmaren Platte (Eaton und Littler Typ I und II) behandelt wurden. In Gruppe A wurden 23 Patienten eingeschlossen, in Gruppe B 21...
  45. Gembruch O, Lemonas E, Ahmadipour Y, Sure U, El Hindy N, Müller O. Nonoperative management of C-2 dens fractures: Single center experience and review of the literature. Clin Neurol Neurosurg. 2018;169:166-173 pubmed publisher
    ..71 patients (mean age 74.08 years ± 16.06 years) were diagnosed with C-2 fractures (Typ I: 4; Typ II 36; Typ III: 31) and treated conservatively using a Philadelphia collar (n = 57), or a ..
  46. Gabele A, Budde J, Spichiger E. [Transition from childhood to adolescence-a qualitative study on experiences of adolescents with type 1 diabetes mellitus and their mothers]. Pflege. 2015;28:69-78 pubmed publisher
    ..Hintergrund: In Deutschland erkranken jährlich etwa 2 200 Kinder unter 14 Jahren an Typ 1 Diabetes mellitus (T1DM)...
  47. Ma L, Bayram Y, McLaughlin H, Cho M, Krokosky A, Turner C, et al. De novo missense variants in PPP1CB are associated with intellectual disability and congenital heart disease. Hum Genet. 2016;135:1399-1409 pubmed
    ..Our data suggest that our heterozygous de novo PPP1CB pathogenic variants are associated with syndromic intellectual disability. ..
  48. Makarowski R, Piotrowski A. [The psychological profile of pilots of passenger planes: Analysis of temperamental traits, aggression and risk]. Med Pr. 2017;68:639-651 pubmed publisher
    ..Wykonane analizy doprowadziły do wyodrębnienia 3 grup pilotów: 1) silny typ układu nerwowego z tendencją do unikania ryzyka, 2) silny typ układu nerwowego z tendencją do ..
  49. Pereira Ã, Viana A, Buono V, Peters O, Bahia M. Behavior of nickel-titanium instruments manufactured with different thermal treatments. J Endod. 2015;41:67-71 pubmed publisher
    ..Specialties, Tulsa, OK), Vortex Blue (VB, Dentsply Tulsa Dental Specialties), and TYPHOON Infinite Flex NiTi (TYP; Clinician's Choice Dental Products, New Milford, CT) (all size 25/.06) were evaluated...
  50. Brinton M, Di H, Vatter H. Simian hemorrhagic fever virus: Recent advances. Virus Res. 2015;202:112-9 pubmed publisher
    ..The catalytic Cys of PLP1α is unusual in being adjacent to an Ala instead of a Typ. PLP1γ cleaves at both downstream and upstream sites...
  51. Räling R, Holzgrefe Lang J, Schröder A, Wartenburger I. On the influence of typicality and age of acquisition on semantic processing: Diverging evidence from behavioural and ERP responses. Neuropsychologia. 2015;75:186-200 pubmed publisher
    Various behavioural studies show that semantic typicality (TYP) and age of acquisition (AOA) of a specific word influence processing time and accuracy during the performance of lexical-semantic tasks...
  52. Bhattacherjee A, Kunar B. Miners' return to work following injuries in coal mines. Med Pr. 2016;67:729-742 pubmed publisher
    ..staż w zawodzie, spożycie alkoholu, czas trwania snu, choroby, stres w pracy, satysfakcję z pracy i typ urazu. Do analizy wyników użyto estymatorów Kaplana-Meiera i modelu proporcjonalnego hazardu Coxa...
  53. Manzano R, Martínez Navarro E, Forteza J, Brugarolas A. Microarray phosphatome profiling of breast cancer patients unveils a complex phosphatase regulatory role of the MAPK and PI3K pathways in estrogen receptor-negative breast cancers. Int J Oncol. 2014;45:2250-66 pubmed publisher
    ..of the MAPK and PI3K pathways in ER- BCs as some of the most differentially expressed phosphatases (like DUSP4 and DUSP6) sharing ERK as substrate, or regulating the PI3K pathway (INPP4B, PTEN)...
  54. Gardini G. A revision of the species of the pseudoscorpion subgenus Chthonius (Ephippiochthonius) (Arachnida, Pseudoscorpiones, Chthoniidae) from Italy and neighbouring areas. Zootaxa. 2013;3655:1-151 pubmed
    ..altamurae n. sp. (♀, loc. typ.: Apulia, Bari Prov., Altamura, Grotta Lamalunga 1295 Pu/BA), C. (E.) elymus n. sp. (♂, loc. typ...
  55. Dougherty J, Kilbane Myers J, Khan M, Angelos M, Chen C. Dual-Specificity Phosphatase 4 Overexpression in Cells Prevents Hypoxia/Reoxygenation-Induced Apoptosis via the Upregulation of eNOS. Front Cardiovasc Med. 2017;4:22 pubmed publisher
    ..Previously, we demonstrated that DUSP4-/- hearts sustain a larger infarct and have poor functional recovery, when isolated hearts were ..
  56. Singh C, Kaur S, George J, Nihal M, Pellitteri Hahn M, Scarlett C, et al. Molecular signatures of sanguinarine in human pancreatic cancer cells: A large scale label-free comparative proteomics approach. Oncotarget. 2015;6:10335-48 pubmed
    ..Four of these proteins (IL33, CUL5, GPS1 and DUSP4) appear to occupy regulatory nodes in key pathways...
  57. Gaggianesi M, Turdo A, Chinnici A, Lipari E, Apuzzo T, Benfante A, et al. IL4 Primes the Dynamics of Breast Cancer Progression via DUSP4 Inhibition. Cancer Res. 2017;77:3268-3279 pubmed publisher
    ..cancer stem-like cells and elevated expression of the dual specificity phosphatase DUSP4 by inhibiting NF-κB. Enforced expression of DUSP4 drove conversion of metastatic cells to nonmetastatic cells...
  58. Lu J, Nguyen L, Samadzadeh S, Masouminia M, Mendoza A, Sweeney O, et al. Expression of proteins upregulated in hepatocellular carcinoma in patients with alcoholic hepatitis (AH) compared to non-alcoholic steatohepatitis (NASH): An immunohistochemical analysis of candidate proteins. Exp Mol Pathol. 2018;104:125-129 pubmed publisher
    ..Liver Meeting as overexpressed in hepatocellular carcinoma: KLF4, SCL19A1, FANCG, HRH-1, DNMT1, DNMT3B, TNFR2, DUSP4, EGFR, Integrin α6, HDACII, PDE3A, BCL-XL, and MTCO2...
  59. Gopallawa I, Uhal B. Angiotensin-(1-7)/mas inhibits apoptosis in alveolar epithelial cells through upregulation of MAP kinase phosphatase-2. Am J Physiol Lung Cell Mol Physiol. 2016;310:L240-8 pubmed publisher
  60. Huang Y, Li T, Jin M, Yin S, Hui K, Ren Q. Newly identified PcToll4 regulates antimicrobial peptide expression in intestine of red swamp crayfish Procambarus clarkii. Gene. 2017;610:140-147 pubmed publisher
    ..PcToll4 contains a signal peptide, 13 LRR domains, 3 LRR TYP domains, 2 LRR CT domains, an LRR NT domain, a transmembrane region, and a TIR domain...
  61. Garner A, Hansen A, Baxley C, Becker S, Sidol C, Beebe D. Effect of sleep extension on sluggish cognitive tempo symptoms and driving behavior in adolescents with chronic short sleep. Sleep Med. 2017;30:93-96 pubmed publisher
    ..hours of sleep completed a five-week at-home experimental protocol: a baseline week to determine typical sleep (TYP), followed in a counterbalanced order by two-week spans in which school-night bedtimes and rise times were (a) ..
  62. Balakirev E, Krupnova T, Ayala F. Symbiotic associations in the phenotypically-diverse brown alga Saccharina japonica. PLoS ONE. 2012;7:e39587 pubmed publisher
    ..We have obtained 16S rRNA sequence data in symbiont microorganisms of the typical form (TYP) of S...
  63. Hutchinson K, Johnson D, Johnson A, Sanchez V, Kuba M, Lu P, et al. ERBB activation modulates sensitivity to MEK1/2 inhibition in a subset of driver-negative melanoma. Oncotarget. 2015;6:22348-60 pubmed
    ..A potential mechanism of ERBB activation in Class II melanomas is minimal expression of the ERK1/2 phosphatase, DUSP4, as ectopic restoration of DUSP4 attenuated ERBB signaling through potential modulation of the ERBB ligand, ..
  64. Hsiao W, Lin Y, Liao F, Chan Y, Huang C. Dual-Specificity Phosphatase 4 Regulates STAT5 Protein Stability and Helper T Cell Polarization. PLoS ONE. 2015;10:e0145880 pubmed publisher
    ..Our previous results found that the deficiency of a dual-specificity phosphatase, DUSP4, induced STAT5 hyper-activation, enhanced IL-2 signaling, and increased T cell proliferation...
  65. Samson F, Zeffiro T, Doyon J, Benali H, Mottron L. Speech acquisition predicts regions of enhanced cortical response to auditory stimulation in autism spectrum individuals. J Psychiatr Res. 2015;68:285-92 pubmed publisher
    ..Onset Delay (AS-SOD and AS-NoSOD, respectively) and were compared with IQ-matched typically developing individuals (TYP)...
  66. Gerovska D, Araúzo Bravo M. Does mouse embryo primordial germ cell activation start before implantation as suggested by single-cell transcriptomics dynamics?. Mol Hum Reprod. 2016;22:208-25 pubmed publisher
    ..5 and steady PE and EPI markers. Among the transitory E3.5 PE markers (Dnmt3l, Dusp4, Cpne8, Akap13, Dcaf12l1, Aaed1, B4galt6, BC100530, Rnpc3, Tfpi, Lgalsl, Ckap4 and Fbxl20), several (Dusp4, Akap13,..
  67. Jung H, Lee S, Kim J, Ahn J, Park Y, Im Y. Statins affect ETS1-overexpressing triple-negative breast cancer cells by restoring DUSP4 deficiency. Sci Rep. 2016;6:33035 pubmed publisher
    ..the transcription factor ets proto-oncogene 1(ets-1) and downregulate dual specific protein phosphatase 4(dusp4) expression...
  68. Kaneko Y, Nakajima T, Irie T, Iizuka T, Tamura S, Kurabayashi M. Atrial and ventricular activation sequence after ventricular induction/entrainment pacing during fast-slow atrioventricular nodal reentrant tachycardia: New insight into the use of V-A-A-V for the differential diagnosis of supraventricular tachycardi. Heart Rhythm. 2017;14:1615-1622 pubmed publisher
    ..We enrolled 28 patients with F/S-AVNRT incorporating a typical slow pathway (typ-F/S-AVNRT) and 9 patients with F/S-AVNRT incorporating a superior slow pathway (sup-F/S-AVNRT)...
  69. Boulding T, Wu F, McCuaig R, Dunn J, Sutton C, Hardy K, et al. Differential Roles for DUSP Family Members in Epithelial-to-Mesenchymal Transition and Cancer Stem Cell Regulation in Breast Cancer. PLoS ONE. 2016;11:e0148065 pubmed publisher
    ..Here we show that DUSP1, DUSP4, and DUSP6 are involved in epithelial-to-mesenchymal transition (EMT) and breast cancer stem cell (CSC) regulation...
  70. Mo S, Liu X, Hao X, Chen W, Zhang K, Cai J, et al. EYA4 functions as tumor suppressor gene and prognostic marker in pancreatic ductal adenocarcinoma through ?-catenin/ID2 pathway. Cancer Lett. 2016;380:403-12 pubmed publisher
    ..We showed that EYA4 functioned as tumor suppressor gene in PDAC via repressing ?-catenin/ID2 activation, and was an independent prognostic factor in PDAC. ..
  71. Solomon M, McCauley J, Iosif A, Carter C, Ragland J. Cognitive control and episodic memory in adolescents with autism spectrum disorders. Neuropsychologia. 2016;89:31-41 pubmed publisher
    ..8; range=12.2-17.9), and 26 age, gender, and IQ-matched adolescents with typical development (TYP) (mean age=14.7 years; SD=1.9; range=12.3-17...
  72. Huang Y, Yang Q, Wang H, Xu Y, Peng W, Jiang Y. Long-term clinical effect of Tangyiping Granules () on patients with impaired glucose tolerance. Chin J Integr Med. 2016;22:653-9 pubmed publisher
    To evaluate the long-term clinical effect of Tangyiping Granules (, TYP) on patients with impaired glucose tolerance (IGT) to achieve normal glucose tolerance (NGT) and hence preventing them from conversion to diabetes mellitus (DM)...
  73. Barbour M, Plevin R, Jiang H. MAP kinase phosphatase 2 deficient mice develop attenuated experimental autoimmune encephalomyelitis through regulating dendritic cells and T cells. Sci Rep. 2016;6:38999 pubmed publisher
    ..While MKP-2 also modulates macrophage activation, our study suggests that MKP-2 is essential to the pathogenic response of EAE, and it acts mainly via regulating the important antigen presenting DC function and T cell activation. ..
  74. Van Boxtel A, Economou A, Heliot C, Hill C. Long-Range Signaling Activation and Local Inhibition Separate the Mesoderm and Endoderm Lineages. Dev Cell. 2018;44:179-191.e5 pubmed publisher
    ..Nodal induces long-range Fgf signaling while simultaneously inducing the cell-autonomous Fgf signaling inhibitor Dusp4 within the first two cell tiers from the margin...
  75. Barajas Espinosa A, Basye A, Jesse E, Yan H, QUAN D, Chen C. Redox activation of DUSP4 by N-acetylcysteine protects endothelial cells from Cd²⁺-induced apoptosis. Free Radic Biol Med. 2014;74:188-199 pubmed publisher
    ..Immunoblotting of endothelial NO synthase (eNOS) and DUSP4, a dual-specificity phosphatase with a cysteine as its active residue, revealed that both enzymes are upregulated ..
  76. Ham J, Oh E, Kim D, Choi S. Differential expression profiles and roles of inducible DUSPs and ERK1/2-specific constitutive DUSP6 and DUSP7 in microglia. Biochem Biophys Res Commun. 2015;467:254-60 pubmed publisher
    ..LPS induced expression of DUSP1, DUSP2, and DUSP5 within 60 min, whereas DUSP4 expression was induced more slowly...
  77. Solomon M, Ragland J, Niendam T, Lesh T, Beck J, Matter J, et al. Atypical Learning in Autism Spectrum Disorders: A Functional Magnetic Resonance Imaging Study of Transitive Inference. J Am Acad Child Adolesc Psychiatry. 2015;54:947-55 pubmed publisher
    ..with ASD aged 12 to 18 years, and 23 gender-, IQ-, and age-matched adolescents with typical development (TYP), completed a transitive inference (TI) task implemented using rapid event-related functional magnetic resonance ..
  78. Abdul Rahman N, Greenwood S, Brett R, Tossell K, Ungless M, Plevin R, et al. Mitogen-Activated Protein Kinase Phosphatase-2 Deletion Impairs Synaptic Plasticity and Hippocampal-Dependent Memory. J Neurosci. 2016;36:2348-54 pubmed publisher
    ..Here, using transgenic mice where the Dusp4 gene encoding MKP-2 has been knocked out (MKP-2(-/-) mice), we show that long-term potentiation is impaired in MKP-..
  79. Wang R, Zhang J, Zhang M, Zhai M, Di S, Han Q, et al. Curcumin attenuates IR-induced myocardial injury by activating SIRT3. Eur Rev Med Pharmacol Sci. 2018;22:1150-1160 pubmed publisher
    ..to curcumin (Cur) treatment in the absence or presence of the silent information regulator 3 (SIRT3) inhibitor 3-TYP and were then subjected to IR. H9c2 cells and male Sprague-Dawley (SD) rats were cultured...
  80. Yan D, Farache J, Mingueneau M, Mathis D, Benoist C. Imbalanced signal transduction in regulatory T cells expressing the transcription factor FoxP3. Proc Natl Acad Sci U S A. 2015;112:14942-7 pubmed publisher
    ..in Treg cells of the signaling modulator CD5, the coinhibitors PD-1 and CTLA4, or the regulatory phosphatase DUSP4. However, transcriptome profiling in Dusp4-deficient mice showed that DUSP4 enhances the expression of a segment ..
  81. Jin X, Li M, Yin L, Zhou J, Zhang Z, Lv H. Tyroservatide-TPGS-paclitaxel liposomes: Tyroservatide as a targeting ligand for improving breast cancer treatment. Nanomedicine. 2017;13:1105-1115 pubmed publisher
    ..glycol 1000 succinate monoester (TPGS)-modified paclitaxel (PTX) liposomes (TP-Lip) to form YSV-conjugated TP-Lip (TYP-Lip)...
  82. Zhang R, Wang G, Zhang P, Zhang J, Huang Y, Lu Y, et al. Sanguinarine inhibits growth and invasion of gastric cancer cells via regulation of the DUSP4/ERK pathway. J Cell Mol Med. 2017;21:1117-1127 pubmed publisher
    ..This study was aimed to investigate the correlation of dual-specificity phosphatase 4 (DUSP4) expression with clinicopathologic features and overall survival in patients with GC and explore the effects of ..
  83. Echavarria R, Hussain S. Regulation of angiopoietin-1/Tie-2 receptor signaling in endothelial cells by dual-specificity phosphatases 1, 4, and 5. J Am Heart Assoc. 2013;2:e000571 pubmed publisher
    ..Ang-1 differentially induces DUSP1, DUSP4, and DUSP5 in human umbilical vein endothelial cells through activation of the PI-3 kinase, ERK1/2, p38, and SAPK/..
  84. Wise R, Zolkiewska A. Metalloprotease-dependent activation of EGFR modulates CD44+/CD24- populations in triple negative breast cancer cells through the MEK/ERK pathway. Breast Cancer Res Treat. 2017;166:421-433 pubmed publisher
    ..there was a positive correlation between EGFR_pY1068 and MEK activation score in tumors without genomic loss of DUSP4, a negative regulator of ERK, but not in tumors harboring DUSP4 deletion...
  85. Mills B, Albert G, Halterman M. Expression Profiling of the MAP Kinase Phosphatase Family Reveals a Role for DUSP1 in the Glioblastoma Stem Cell Niche. Cancer Microenviron. 2017;10:57-68 pubmed publisher
    ..Interrogation of the REpository for Molecular BRAin Neoplasia DaTa (REMBRANDT) revealed induction (DUSP4, DUSP6), repression (DUSP2, DUSP7-9), or mixed (DUSP1, DUSP5, DUSP10, DUSP15) DUSP transcription of select DUSPs ..
  86. Waha A, Felsberg J, Hartmann W, von dem Knesebeck A, Mikeska T, Joos S, et al. Epigenetic downregulation of mitogen-activated protein kinase phosphatase MKP-2 relieves its growth suppressive activity in glioma cells. Cancer Res. 2010;70:1689-99 pubmed publisher
    ..a CpG-rich region of the promoter of the dual-specificity mitogen-activated protein kinase phosphatase-2 gene (DUSP4/MKP-2) that is hypermethylated in gliomas...
  87. Schmid C, Robinson M, Scheifinger N, Müller S, Cogliatti S, Tzankov A, et al. DUSP4 deficiency caused by promoter hypermethylation drives JNK signaling and tumor cell survival in diffuse large B cell lymphoma. J Exp Med. 2015;212:775-92 pubmed publisher
    ..We find that a CpG island in the promoter of the dual-specificity phosphatase DUSP4 is aberrantly methylated in nodal and extranodal DLBCL, irrespective of ABC or GCB subtype, resulting in loss of ..
  88. Kang X, Li M, Zhu H, Lu X, Miao J, Du S, et al. DUSP4 promotes doxorubicin resistance in gastric cancer through epithelial-mesenchymal transition. Oncotarget. 2017;8:94028-94039 pubmed publisher
    ..Dual specificity phosphatase 4 (DUSP4) has been associated with tumor progression...
  89. Cagnol S, Rivard N. Oncogenic KRAS and BRAF activation of the MEK/ERK signaling pathway promotes expression of dual-specificity phosphatase 4 (DUSP4/MKP2) resulting in nuclear ERK1/2 inhibition. Oncogene. 2013;32:564-76 pubmed publisher
    ..Nuclear ERK dephosphorylation was found to be tightly correlated with the rapid expression of DUSP4 phosphatase induced in an MEK-dependent manner...
  90. Haagenson K, Zhang J, Xu Z, Shekhar M, Wu G. Functional analysis of MKP-1 and MKP-2 in breast cancer tamoxifen sensitivity. Oncotarget. 2014;5:1101-10 pubmed
    ..These data suggest that MKP-2 rather than MKP-1 is tamoxifen-regulated and that the elevated expression of MKP-2 in MCF7-TAMR cells potentially functions to restore tamoxifen sensitivity. ..
  91. Ichimanda M, Hijiya N, Tsukamoto Y, Uchida T, Nakada C, Akagi T, et al. Downregulation of dual-specificity phosphatase 4 enhances cell proliferation and invasiveness in colorectal carcinomas. Cancer Sci. 2018;109:250-258 pubmed publisher
    ..we reported that constitutive activation of MAPK accompanied by downregulation of dual-specificity phosphatase 4 (DUSP4), a MAPK phosphatase, contributes to the progression of precursor lesions in the pancreas...
  92. De Vriendt V, De Roock W, Di Narzo A, Tian S, Biesmans B, Jacobs B, et al. DUSP 4 expression identifies a subset of colorectal cancer tumors that differ in MAPK activation, regardless of the genotype. Biomarkers. 2013;18:516-24 pubmed publisher
    ..In three different CRC patient microarray datasets, we analyzed the expression of DUSP1. DUSP4 and DUSP6 according to mutational status, their correlation with survival and their association with different ..