DUSP28

Summary

Gene Symbol: DUSP28
Description: dual specificity phosphatase 28
Alias: DUSP26, VHP, dual specificity phosphatase 28
Species: human
Products:     DUSP28

Top Publications

  1. Yoshida K, Drew M, Mimura M, Tanaka K. Serotonin-mediated inhibition of ventral hippocampus is required for sustained goal-directed behavior. Nat Neurosci. 2019;: pubmed publisher
    ..suppression is required for goal-directed behavior, whereas optogenetic suppression of the ventral hippocampus (vHP) enhances the ability to sustain goal-directed behavior...
  2. Lee J, Lee J, Kim J. Scattered DUSP28 is a novel biomarker responsible for aggravating malignancy via the autocrine and paracrine signaling in metastatic pancreatic cancer. Cancer Lett. 2019;: pubmed publisher
    ..We have reported that dual specificity phosphatise 28 (DUSP28) could be secreted in pancreatic cancer cells. However, its biological function is poorly understood...
  3. de Lannoy G, Luyckx I, Vuylsteke B. The diffusion of hydrogen peroxide into the liquid product during filling operations inside vaporous hydrogen peroxide-sterilized isolators can be predicted by a mechanistic model. J Pharm Sci. 2019;: pubmed publisher
    ..To ensure an aseptic inner environment, isolators are regularly sterilized with vaporised hydrogen peroxide (VHP)...
  4. Ragland N, Miedel E, Engelman R. PCR Prevalence of Murine Opportunistic Microbes and their Mitigation by Using Vaporized Hydrogen Peroxide. J Am Assoc Lab Anim Sci. 2019;58:208-215 pubmed publisher
    ..Vaporized hydrogen peroxide (VHP) exposure of IVC equipment left unassembled (that is, in a 'static-open' configuration) did not eliminate PCR ..
  5. Maina S, Stylianou E, Vogiatzi E, Vlysidis A, Mallouchos A, Nychas G, et al. Improvement on bioprocess economics for 2,3-butanediol production from very high polarity cane sugar via optimisation of bioreactor operation. Bioresour Technol. 2018;274:343-352 pubmed publisher
    ..in fed-batch cultures carried out with the bacterial strain Enterobacter ludwigii using very high polarity (VHP) sugar from sugarcane mills...
  6. Lokareddy R, Bhardwaj A, Cingolani G. Atomic structure of dual-specificity phosphatase 26, a novel p53 phosphatase. Biochemistry. 2013;52:938-48 pubmed publisher
    ..Dual-specificity phosphatase 26 (DUSP26) is a brain phosphatase highly overexpressed in neuroblastoma, which has been implicated in dephosphorylating ..
  7. Miedel E, Ragland N, Engelman R. Facility-wide Eradication of Corynebacterium bovis by using PCR-validated Vaporized Hydrogen Peroxide. J Am Assoc Lab Anim Sci. 2018;57:465-476 pubmed publisher
    Facility-wide Corynebacterium bovis eradication was established using vaporized hydrogen peroxide (VHP) decontamination guided by C. bovis PCR surveillance...
  8. Yu G, Sharp B. Basolateral amygdala and ventral hippocampus in stress-induced amplification of nicotine self-administration during reacquisition in rat. Psychopharmacology (Berl). 2015;232:2741-9 pubmed publisher
    ..Similarly, ventral hippocampus (vHP) was inactivated or disconnected from BLA...
  9. Pavic K, Duan G, Köhn M. VHR/DUSP3 phosphatase: structure, function and regulation. FEBS J. 2015;282:1871-90 pubmed publisher
    ..We give a detailed overview of VHR/DUSP3 phosphatase and compare it with its most closely related phosphatases DUSP13B, DUSP26 and DUSP27.

More Information

Publications52

  1. Takata N, Yoshida K, Komaki Y, Xu M, Sakai Y, Hikishima K, et al. Optogenetic activation of CA1 pyramidal neurons at the dorsal and ventral hippocampus evokes distinct brain-wide responses revealed by mouse fMRI. PLoS ONE. 2015;10:e0121417 pubmed publisher
    The dorsal and ventral hippocampal regions (dHP and vHP) are proposed to have distinct functions. Electrophysiological studies have revealed intra-hippocampal variances along the dorsoventral axis...
  2. Papadaki A, Papapostolou H, Alexandri M, Kopsahelis N, Papanikolaou S, de Castro A, et al. Fumaric acid production using renewable resources from biodiesel and cane sugar production processes. Environ Sci Pollut Res Int. 2018;25:35960-35970 pubmed publisher
    ..NRRL 2582 has been evaluated using soybean cake from biodiesel production processes and very high polarity (VHP) sugar from sugarcane mills...
  3. Monge Palacios M, Rissanen M, Wang Z, Sarathy S. Theoretical kinetic study of the formic acid catalyzed Criegee intermediate isomerization: multistructural anharmonicity and atmospheric implications. Phys Chem Chem Phys. 2018;20:10806-10814 pubmed publisher
    ..of a six carbon atom Criegee intermediate (C6-CI), catalyzed by formic acid (HCOOH), to produce vinylhydroperoxide (VHP), C6-CI + HCOOH → VHP + HCOOH...
  4. Chiba F, Makino Y, Torimitsu S, Motomura A, Inokuchi G, Ishii N, et al. Stature estimation based on femoral measurements in the modern Japanese population: a cadaveric study using multidetector computed tomography. Int J Legal Med. 2018;132:1485-1491 pubmed publisher
    ..of the femur on the osteometric board using reconstructed CT images, we defined a virtual horizontal plane (VHP) based on the three most dorsal points of the femur (lateral condyle, medial condyle, and greater trochanter)...
  5. Ragland N, Miedel E, Gómez J, Engelman R. Staphylococcus xylosus PCR-validated Decontamination of Murine Individually Ventilated Cage Racks and Air Handling Units by Using 'Active-Closed' Exposure to Vaporized Hydrogen Peroxide. J Am Assoc Lab Anim Sci. 2017;56:742-751 pubmed
    Vaporized hydrogen peroxide (VHP) is used to decontaminate clinical, biocontainment, and research animal rooms and equipment...
  6. Matsumoto S, Yamada Y, Hashimoto M, Okamura T, Yamada M, Yashima F, et al. CT imaging before transcatheter aortic valve implantation (TAVI) using variable helical pitch scanning and its diagnostic performance for coronary artery disease. Eur Radiol. 2017;27:1963-1970 pubmed publisher
    To evaluate the effectiveness of CT before TAVI using variable helical pitch (VHP) scanning and its diagnostic performance for coronary artery disease (CAD). Sixty patients (84.4?±?4...
  7. Coffey J, Culligan K, Walsh L, Sehgal R, Dunne C, McGrath D, et al. An appraisal of the computed axial tomographic appearance of the human mesentery based on mesenteric contiguity from the duodenojejunal flexure to the mesorectal level. Eur Radiol. 2016;26:714-21 pubmed publisher
    ..and reference atlas of the mesentery were generated using the full-colour data set of the Visible Human Project (VHP). Seventy one normal abdominal CT images were examined to identify mesenteric regions...
  8. Yanamadala J, Noetscher G, Rathi V, Maliye S, Win H, Tran A, et al. New VHP-Female v. 2.0 full-body computational phantom and its performance metrics using FEM simulator ANSYS HFSS. Conf Proc IEEE Eng Med Biol Soc. 2015;2015:3237-41 pubmed publisher
    ..full-body electromagnetic computational model (computational phantom), the Visible Human Project(®) (VHP)-Female v. 2.0 and to describe its distinct features...
  9. Hsu T, Hahn J, Konanur V, Noble E, Suarez A, Thai J, et al. Hippocampus ghrelin signaling mediates appetite through lateral hypothalamic orexin pathways. elife. 2015;4: pubmed publisher
    ..aspects of feeding through which the gut-derived hormone ghrelin communicates with ventral hippocampus (vHP) neurons to stimulate meal-entrained conditioned appetite...
  10. Ren J, Cheng Z, Huang Y, Zhao J, Guo P, Zou Z, et al. Identification of novel dual-specificity phosphatase 26 inhibitors by a hybrid virtual screening approach based on pharmacophore and molecular docking. Biomed Pharmacother. 2017;89:376-385 pubmed publisher
    Dual-specificity phosphatase 26 (DUSP26) has recently emerged as a target for treatment of human cancers. However, only two small-molecule inhibitors of DUSP26 are known so far, namely NSC-87877 and ethyl-3, 4-dephostatin...
  11. Bourgonje A, Verrijp K, Schepens J, Navis A, Piepers J, Palmen C, et al. Comprehensive protein tyrosine phosphatase mRNA profiling identifies new regulators in the progression of glioma. Acta Neuropathol Commun. 2016;4:96 pubmed publisher
    ..Notably, seven PTP genes (DUSP26, MTMR4, PTEN, PTPRM, PTPRN2, PTPRT and PTPRZ1) were differentially expressed between grade II-III gliomas and (..
  12. Yang C, Yeh Y, Wang J, Liu Y, Chen Y, Cheng H, et al. NEAP/DUSP26 suppresses receptor tyrosine kinases and regulates neuronal development in zebrafish. Sci Rep. 2017;7:5241 pubmed publisher
    Expression of neuroendocrine-associated phosphatase (NEAP, also named as dual specificity phosphatase 26, [DUSP26]) is restricted to neuroendocrine tissues...
  13. Jung S, Nah J, Han J, Choi S, Kim H, Park J, et al. Dual-specificity phosphatase 26 (DUSP26) stimulates Aβ42 generation by promoting amyloid precursor protein axonal transport during hypoxia. J Neurochem. 2016;137:770-81 pubmed publisher
    ..In this study, we showed that dual-specificity phosphatase 26 (DUSP26) regulates Aβ generation through changes in subcellular localization of the γ-secretase complex and its ..
  14. Balaya V, Uhl J, Lanore A, Salachas C, Samoyeau T, Ngo C, et al. [3D modeling of the female pelvis by Computer-Assisted Anatomical Dissection: Applications and perspectives]. J Gynecol Obstet Biol Reprod (Paris). 2016;45:467-77 pubmed publisher
    ..From the database of "visible female" of Visible Human Project(®) (VHP) of the "national library of medicine" NLM (United States), we used 739 transverse anatomical slices of 0...
  15. Kanoski S, Hayes M, Skibicka K. GLP-1 and weight loss: unraveling the diverse neural circuitry. Am J Physiol Regul Integr Comp Physiol. 2016;310:R885-95 pubmed publisher
    ..area), hindbrain nuclei (parabrachial nucleus, medial nucleus tractus solitarius), hippocampus (ventral subregion; vHP), and nuclei embedded within the mesolimbic reward circuitry [ventral tegmental area (VTA) and nucleus accumbens (..
  16. Kishimoto A, Kimura S, Nio Kobayashi J, Takahashi Iwanaga H, Park A, Iwanaga T. Histochemical characteristics of regressing vessels in the hyaloid vascular system of neonatal mice: Novel implication for vascular atrophy. Exp Eye Res. 2018;172:1-9 pubmed publisher
    ..Macrophages immunoreactive for F4/80, cathepsin D, and LYVE-1 gathered around the vasa hyaloidea propria (VHP), while small round cells in vascular lumen of VHP were selectively immunoreactive for galectin-3; their segmented ..
  17. Ellis K, Zhou Y, Rodriguez Murillo L, Beshansky J, Ainehsazan E, Selker H, et al. Common variants associated with changes in levels of circulating free fatty acids after administration of glucose-insulin-potassium (GIK) therapy in the IMMEDIATE trial. Pharmacogenomics J. 2017;17:76-83 pubmed publisher
    ..47 × 10-7). Nearest to DUSP26, rs7464104 was associated with a decrease in unsaturated FFAs (P2df=5.51 × 10-7)...
  18. Shang X, Vasudevan S, Yu Y, Ge N, Ludwig A, Wesson C, et al. Dual-specificity phosphatase 26 is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma. Oncogene. 2010;29:4938-46 pubmed publisher
    ..In this study, we investigated the expression and function of dual-specificity phosphatase 26 (DUSP26), also known as mitogen-activated protein kinase phophatase-8, in human neuroblastoma...
  19. Zhu W, Mao Z, Zhu C, Li M, Cao C, Guan Y, et al. Adolescent exposure to cocaine increases anxiety-like behavior and induces morphologic and neurochemical changes in the hippocampus of adult rats. Neuroscience. 2016;313:174-83 pubmed publisher
    ..Dorsal hippocampus (dHP) has been implicated in learning and memory, whereas ventral hippocampus (vHP) plays an important role in emotional processing...
  20. Noetscher G, Yanamadala J, Tankaria H, Louie S, Prokop A, Nazarian A, et al. Computational human model VHP-FEMALE derived from datasets of the national library of medicine. Conf Proc IEEE Eng Med Biol Soc. 2016;2016:3350-3353 pubmed publisher
    ..platform-independent and computationally-efficient full-body electromagnetic model, the Visible Human Project® (VHP)-Female v.3.0 and to outline its distinct features...
  21. Shi Y, Ma I, Patel R, Shang X, Zhao Y, Cheng J, et al. NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis. Cell Death Dis. 2015;6:e1841 pubmed publisher
    Dual specificity protein phosphatase 26 (DUSP26) is overexpressed in high-risk neuroblastoma (NB) and contributes to chemoresistance by inhibiting p53 function. In vitro, DUSP26 has also been shown to effectively inhibit p38 MAP kinase...
  22. Tankaria H, Jackson X, Borwankar R, Srichandhru G, Le Tran A, Yanamadala J, et al. VHP-Female full-body human CAD model for cross-platform FEM simulations: recent development and validations. Conf Proc IEEE Eng Med Biol Soc. 2016;2016:2232-2235 pubmed publisher
    ..full-body electromagnetic computational model (computational phantom), the Visible Human Project® (VHP)-Female v. 3.1 and to describe its distinct features and enhancements compared to VHP-Female v. 2.0...
  23. Tran A, Makarov S. Degree of RF MRI coil detuning for an anatomically realistic respiratory cycle modeled with the finite element method. Conf Proc IEEE Eng Med Biol Soc. 2017;2017:1405-1408 pubmed publisher
    ..Using the concept of an ideal (perfectly matched and tuned at all available ports) RF transmit coil and the VHP-Female v4...
  24. Ku B, Hong W, Keum C, Kim M, Ryu H, Jeon D, et al. Structural and biochemical analysis of atypically low dephosphorylating activity of human dual-specificity phosphatase 28. PLoS ONE. 2017;12:e0187701 pubmed publisher
    ..b>DUSP28 is one of the DUSP subfamily members that is known to be implicated in the progression of hepatocellular and ..
  25. Wang D, Han S, Peng R, Jiao C, Wang X, Han Z, et al. DUSP28 contributes to human hepatocellular carcinoma via regulation of the p38 MAPK signaling. Int J Oncol. 2014;45:2596-604 pubmed publisher
    b>DUSP28, a member of the atypical dual‑specificity phosphatase (DUSP) family, is a candidate tumor-related gene in hepatocellular carcinoma (HCC) selected by genome‑wide approach, but its pathological role in HCC has not been ..
  26. Wang L, Wang L. Mechanism of gas-phase ozonolysis of sabinene in the atmosphere. Phys Chem Chem Phys. 2017;19:24209-24218 pubmed publisher
    ..Calculations showed that the stabilized CI-1 would undergo a rapid intramolecular H-shift to a vinyl hydroperoxide (VHP) at a rate of ?2700 s-1 followed by rapid decomposition to an OH radical and a vinoxy-type radical (VTR) ..
  27. Robustillo Rodela A, Pérez Blanco V, Espinel Ruiz M, Ruiz Carrascoso G, Figueira Iglesias J, Abad Martín D. Successful control of 2 simultaneous outbreaks of OXA-48 carbapenemase-producing Enterobacteriaceae and multidrug-resistant Acinetobacter baumannii in an intensive care unit. Am J Infect Control. 2017;45:1356-1362 pubmed publisher
    ..ICU) and the effectiveness of measures implemented, including decontamination with vaporized hydrogen peroxide (VHP). Affected patients were isolated in a confined area and cared for by dedicated personnel...
  28. Massey J, Prokop A, Yilmaz A. A comparison of two anatomical body models derived from the female visible human project data. Conf Proc IEEE Eng Med Biol Soc. 2017;2017:2162-2165 pubmed publisher
    ..human body models independently developed from the same image dataset-the voxel-based AustinWoman and surface-based VHP-Female models- are compared...
  29. Jia H, Li Y, Sun B, Zhao S, Yi Y, Zhao M, et al. Evaluation of vaporized hydrogen peroxide fumigation as a method for the bio-decontamination of the high efficiency particulate air filter unit. Biomed Environ Sci. 2013;26:110-7 pubmed publisher
    To evaluate the performance of vaporized hydrogen peroxide (VHP) for the bio-decontamination of the high efficiency particulate air (HEPA) filter unit...
  30. Lee J, Lee J, Yun J, Choi C, Cho S, Kim S, et al. Autocrine DUSP28 signaling mediates pancreatic cancer malignancy via regulation of PDGF-A. Sci Rep. 2017;7:12760 pubmed publisher
    ..We have reported that dual specificity phosphatase 28 (DUSP28) has a critical role of chemo-resistance and migration in pancreatic cancers...
  31. Inaba H, Yoda K, Adachi H. The F-actin-binding RapGEF GflB is required for efficient macropinocytosis in Dictyostelium. J Cell Sci. 2017;130:3158-3172 pubmed publisher
    ..GflB localized to the actin cortex most prominently at crowns and phagocytic cups. The villin headpiece domain (VHP)-like N-terminal domain of GflB directly interacted with F-actin in vitro Furthermore, a domain enriched in ..
  32. Hsu T, Noble E, Reiner D, Liu C, Suarez A, Konanur V, et al. Hippocampus ghrelin receptor signaling promotes socially-mediated learned food preference. Neuropharmacology. 2018;131:487-496 pubmed publisher
    ..results show that relative to vehicle treatment, ghrelin targeted to the ventral CA1 subregion of the hippocampus (vHP) enhanced STFP learning in rats...
  33. Zhang Z, Liu L, Twumasi Boateng K, Block D, Shapira M. FOS-1 functions as a transcriptional activator downstream of the C. elegans JNK homolog KGB-1. Cell Signal. 2017;30:1-8 pubmed publisher
    ..activation either in developing larvae or in adults, achieved by knocking down its negative phosphatase regulator vhp-1...
  34. Moureau N, Trick N, Nifong T, Perry C, Kelley C, Carrico R, et al. Vessel health and preservation (Part 1): a new evidence-based approach to vascular access selection and management. J Vasc Access. 2012;13:351-6 pubmed publisher
    ..The Vessel Health and Preservation (VHP) programme incorporates evidence-based practices focused on timely, intentional proactive device selection ..
  35. Lee J, Hun Yun J, Lee J, Choi C, Hoon Kim J. Blockade of dual-specificity phosphatase 28 decreases chemo-resistance and migration in human pancreatic cancer cells. Sci Rep. 2015;5:12296 pubmed publisher
    ..In the present study, we investigated the role of dual specificity phosphatase 28 (DUSP28) in relation to anti-cancer drug sensitivity and migratory activity in human pancreatic ..
  36. Rogers W, Zhang L, Welden S, Krieger B, Rickels M, Moore J, et al. Vascular Health Profile predicts cardiovascular outcomes in patients with diabetes. Cytometry B Clin Cytom. 2017;92:258-265 pubmed publisher
    We previously reported the development of a novel high dimensional cytomic assay, the Vascular Health Profile (VHP) based on measurements of angiogenic circulating hematopoietic stem and progenitor cells (CHSPCAng ) and ..
  37. Lee J, Lee J, Yun J, Jeong D, Kim J. DUSP28 links regulation of Mucin 5B and Mucin 16 to migration and survival of AsPC-1 human pancreatic cancer cells. Tumour Biol. 2016;37:12193-12202 pubmed
    ..Dual-specificity phosphatase 28 (DUSP28) is highly expressed in human pancreatic cancers and exerts critical effects...
  38. Borch Pedersen K, Mellegård H, Reineke K, Boysen P, Sevenich R, Lindbäck T, et al. Effects of High Pressure on Bacillus licheniformis Spore Germination and Inactivation. Appl Environ Microbiol. 2017;83: pubmed publisher
    ..In contrast to Bacillus subtilis spores, treatment with very HP (vHP) of 550 MPa at 37°C did not promote effective germination of B. licheniformis spores...
  39. Khan A, Hansen B, Wiborg O, Kroenke C, Jespersen S. Diffusion MRI and MR spectroscopy reveal microstructural and metabolic brain alterations in chronic mild stress exposed rats: A CMS recovery study. Neuroimage. 2018;167:342-353 pubmed publisher
    ..rats from the unpredictable CMS model of depression to study metabolic recovery in the ventral hippocampus (vHP) and microstructural recovery in the HP, AM, CP, and PFC...
  40. Sun T, Xu L, Sun H, Yue Q, Zhai H, Yao Y. VvVHP1; 2 Is Transcriptionally Activated by VvMYBA1 and Promotes Anthocyanin Accumulation of Grape Berry Skins via Glucose Signal. Front Plant Sci. 2017;8:1811 pubmed publisher
    In this work, four vacuolar H+-PPase (VHP) genes were identified in the grape genome...
  41. Noetscher G, Htet A, Maino N, Lacroix P. The Visible Human Project male CAD based computational phantom and its use in bioelectromagnetic simulations. Conf Proc IEEE Eng Med Biol Soc. 2017;2017:4227-4230 pubmed publisher
    ..This paper describes the construction of a new CAD based male computational phantom, the Visible Human Project (VHP)-Male model, suitable for use in major commercial electromagnetics simulation packages.
  42. Jeong D, Wei C, Ku B, Jeon T, Chien P, Kim J, et al. The family-wide structure and function of human dual-specificity protein phosphatases. Acta Crystallogr D Biol Crystallogr. 2014;70:421-35 pubmed publisher
    ..The family-wide structures of DUSPs form a basis for the understanding of phosphorylation-mediated signal transduction and the development of therapeutics. ..
  43. Yang Y, Jin L, Zhang J, Wang J, Zhao X, Wu G, et al. High HSF4 expression is an independent indicator of poor overall survival and recurrence free survival in patients with primary colorectal cancer. IUBMB Life. 2017;69:956-961 pubmed publisher
    ..958, 95%CI: 1.224-3.131, P = 0.005). Bioinformatic analysis showed that HSF4 can directly interact with DUSP26, ZBED8, and MAPK14...