Gene Symbol: DUSP26
Description: dual specificity phosphatase 26
Alias: DSP-4, DUSP24, LDP-4, MKP-8, MKP8, NATA1, NEAP, SKRP3, dual specificity protein phosphatase 26, MAP kinase phosphatase 8, Novel amplified gene in thyroid anaplastic cancer, dual specificity phosphatase 26 (putative), dual specificity phosphatase SKRP3, low-molecular-mass dual-specificity phosphatase 4, mitogen-activated protein kinase phosphatase 8, neuroendocrine-associated phosphatase
Species: human
Products:     DUSP26

Top Publications

  1. Hu Y, Mivechi N. Association and regulation of heat shock transcription factor 4b with both extracellular signal-regulated kinase mitogen-activated protein kinase and dual-specificity tyrosine phosphatase DUSP26. Mol Cell Biol. 2006;26:3282-94 pubmed
    ..Surprisingly, Hsf4b also interacts with an ERK-specific dual-specificity tyrosine phosphatase named DUSP26 identified from a yeast two-hybrid screen...
  2. Shang X, Vasudevan S, Yu Y, Ge N, Ludwig A, Wesson C, et al. Dual-specificity phosphatase 26 is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma. Oncogene. 2010;29:4938-46 pubmed publisher
    ..In this study, we investigated the expression and function of dual-specificity phosphatase 26 (DUSP26), also known as mitogen-activated protein kinase phophatase-8, in human neuroblastoma...
  3. Vasudevan S, Skoko J, Wang K, Burlingame S, Patel P, Lazo J, et al. MKP-8, a novel MAPK phosphatase that inhibits p38 kinase. Biochem Biophys Res Commun. 2005;330:511-8 pubmed
    ..When co-expressed with activated MAPKs, MKP-8 is able to inhibit p38 kinase phosphorylation and downstream activity. ..
  4. Tanuma N, Nomura M, Ikeda M, Kasugai I, Tsubaki Y, Takagaki K, et al. Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediated cell-cell adhesion. Oncogene. 2009;28:752-61 pubmed publisher
    ..In this study, we report identification of the protein-phosphatase Dusp26 as a novel regulator of the KIF3 motor...
  5. Takagaki K, Shima H, Tanuma N, Nomura M, Satoh T, Watanabe M, et al. Characterization of a novel low-molecular-mass dual specificity phosphatase-4 (LDP-4) expressed in brain. Mol Cell Biochem. 2007;296:177-84 pubmed
    ..When expressed in COS-7 cells, FLAG-tagged LDP-4 protein was present within the nucleus and Golgi apparatus. LDP-4 expression did not reduce phosphorylation levels of MAPKs, but rather evoked activation of JNK and p38. ..
  6. Wang J, Lin C, Yang C, Tan T, Chen Y. Biochemical and biological characterization of a neuroendocrine-associated phosphatase. J Neurochem. 2006;98:89-101 pubmed
    The biochemical and biological properties of a novel neuroendocrine-associated phosphatase (NEAP) were characterized...
  7. Wang J, Yang C, Yeh C, Lin C, Chen Y. NEAP causes down-regulation of EGFR, subsequently induces the suppression of NGF-induced differentiation in PC12 cells. J Neurochem. 2008;107:1544-55 pubmed publisher
    Neuroendocrine-associated phosphatase (NEAP), an atypical dual specificity phosphatase is preferentially expressed in neuroendocrine cells...
  8. Yu W, Imoto I, Inoue J, Onda M, Emi M, Inazawa J. A novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity. Oncogene. 2007;26:1178-87 pubmed
    ..14 ATC cell lines with further fluorescence in situ hybridization analysis, we demonstrated amplification of the DUSP26 gene, known by another report as MAP kinase phosphatase-8...
  9. Adio A, Casteel C, De Vos M, Kim J, Joshi V, Li B, et al. Biosynthesis and defensive function of Nδ-acetylornithine, a jasmonate-induced Arabidopsis metabolite. Plant Cell. 2011;23:3303-18 pubmed publisher
    ..experiments show that, after MeJA elicitation, Arg, Pro, and Glu are converted to Orn, which is acetylated by NATA1 to produce N(δ)-acetylornithine...

More Information


  1. Pavic K, Duan G, Köhn M. VHR/DUSP3 phosphatase: structure, function and regulation. FEBS J. 2015;282:1871-90 pubmed publisher
    ..We give a detailed overview of VHR/DUSP3 phosphatase and compare it with its most closely related phosphatases DUSP13B, DUSP26 and DUSP27.
  2. Lemarié S, Robert Seilaniantz A, Lariagon C, Lemoine J, Marnet N, Jubault M, et al. Both the Jasmonic Acid and the Salicylic Acid Pathways Contribute to Resistance to the Biotrophic Clubroot Agent Plasmodiophora brassicae in Arabidopsis. Plant Cell Physiol. 2015;56:2158-68 pubmed publisher
    ..Finally, we showed that the JA-mediated induction of NATA1 drove N(δ)-acetylornithine biosynthesis in infected Col-0 roots...
  3. Bourgonje A, Verrijp K, Schepens J, Navis A, Piepers J, Palmen C, et al. Comprehensive protein tyrosine phosphatase mRNA profiling identifies new regulators in the progression of glioma. Acta Neuropathol Commun. 2016;4:96 pubmed publisher
    ..Notably, seven PTP genes (DUSP26, MTMR4, PTEN, PTPRM, PTPRN2, PTPRT and PTPRZ1) were differentially expressed between grade II-III gliomas and (..
  4. Yang C, Yeh Y, Wang J, Liu Y, Chen Y, Cheng H, et al. NEAP/DUSP26 suppresses receptor tyrosine kinases and regulates neuronal development in zebrafish. Sci Rep. 2017;7:5241 pubmed publisher
    Expression of neuroendocrine-associated phosphatase (NEAP, also named as dual specificity phosphatase 26, [DUSP26]) is restricted to neuroendocrine tissues...
  5. Ren J, Cheng Z, Huang Y, Zhao J, Guo P, Zou Z, et al. Identification of novel dual-specificity phosphatase 26 inhibitors by a hybrid virtual screening approach based on pharmacophore and molecular docking. Biomed Pharmacother. 2017;89:376-385 pubmed publisher
    Dual-specificity phosphatase 26 (DUSP26) has recently emerged as a target for treatment of human cancers. However, only two small-molecule inhibitors of DUSP26 are known so far, namely NSC-87877 and ethyl-3, 4-dephostatin...
  6. Shi Y, Ma I, Patel R, Shang X, Zhao Y, Cheng J, et al. NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis. Cell Death Dis. 2015;6:e1841 pubmed publisher
    b>Dual specificity protein phosphatase 26 (DUSP26) is overexpressed in high-risk neuroblastoma (NB) and contributes to chemoresistance by inhibiting p53 function. In vitro, DUSP26 has also been shown to effectively inhibit p38 MAP kinase...
  7. Lou Y, Bor M, Yan J, Preuss A, Jander G. Arabidopsis NATA1 Acetylates Putrescine and Decreases Defense-Related Hydrogen Peroxide Accumulation. Plant Physiol. 2016;171:1443-55 pubmed publisher
    ..Here we show that Arabidopsis (Arabidopsis thaliana) N-ACETYLTRANSFERASE ACTIVITY1 (NATA1) catalyzes acetylation of putrescine to N-acetylputrescine and thereby competes with spermidine synthase for a ..
  8. Ellis K, Zhou Y, Rodriguez Murillo L, Beshansky J, Ainehsazan E, Selker H, et al. Common variants associated with changes in levels of circulating free fatty acids after administration of glucose-insulin-potassium (GIK) therapy in the IMMEDIATE trial. Pharmacogenomics J. 2017;17:76-83 pubmed publisher
    ..47 × 10-7). Nearest to DUSP26, rs7464104 was associated with a decrease in unsaturated FFAs (P2df=5.51 × 10-7)...
  9. Kim H, Lee H, Oh Y, Choi S, Hong S, Kim H, et al. The DUSP26 phosphatase activator adenylate kinase 2 regulates FADD phosphorylation and cell growth. Nat Commun. 2014;5:3351 pubmed publisher
    ..AK2 forms a complex with dual-specificity phosphatase 26 (DUSP26) phosphatase and stimulates DUSP26 activity independently of its AK activity...
  10. Lokareddy R, Bhardwaj A, Cingolani G. Atomic structure of dual-specificity phosphatase 26, a novel p53 phosphatase. Biochemistry. 2013;52:938-48 pubmed publisher
    ..Dual-specificity phosphatase 26 (DUSP26) is a brain phosphatase highly overexpressed in neuroblastoma, which has been implicated in dephosphorylating ..
  11. Yang Y, Jin L, Zhang J, Wang J, Zhao X, Wu G, et al. High HSF4 expression is an independent indicator of poor overall survival and recurrence free survival in patients with primary colorectal cancer. IUBMB Life. 2017;69:956-961 pubmed publisher
    ..958, 95%CI: 1.224-3.131, P = 0.005). Bioinformatic analysis showed that HSF4 can directly interact with DUSP26, ZBED8, and MAPK14...
  12. Jung S, Nah J, Han J, Choi S, Kim H, Park J, et al. Dual-specificity phosphatase 26 (DUSP26) stimulates Aβ42 generation by promoting amyloid precursor protein axonal transport during hypoxia. J Neurochem. 2016;137:770-81 pubmed publisher
    ..In this study, we showed that dual-specificity phosphatase 26 (DUSP26) regulates Aβ generation through changes in subcellular localization of the γ-secretase complex and its ..
  13. Prabhakar S, Asuthkar S, Lee W, Chigurupati S, Zakharian E, Tsung A, et al. Targeting DUSPs in glioblastomas - wielding a double-edged sword?. Cell Biol Int. 2014;38:145-53 pubmed publisher
    ..This review identifies and summarize the specific roles of DUSP1, DUSP4, DUSP6 and DUSP26 that have been implicated in GBM.
  14. Won E, Xie Y, Takemoto C, Chen L, Liu Z, Wang B, et al. High-resolution crystal structure of the catalytic domain of human dual-specificity phosphatase 26. Acta Crystallogr D Biol Crystallogr. 2013;69:1160-70 pubmed publisher
    ..Human DUSP26 inhibits the apoptosis of cancer cells by dephosphorylating substrates such as p38 and p53...
  15. Patterson K, Brummer T, Daly R, O Brien P. DUSP26 negatively affects the proliferation of epithelial cells, an effect not mediated by dephosphorylation of MAPKs. Biochim Biophys Acta. 2010;1803:1003-12 pubmed publisher
    ..The aim of this study was to characterise the phosphatase activity of the atypical dual specificity phosphatase, DUSP26 on MAP kinases, and to determine its expression, regulation and function in cancer cells...