Gene Symbol: DUSP23
Description: dual specificity phosphatase 23
Alias: DUSP25, LDP-3, MOSP, VHZ, dual specificity protein phosphatase 23, VH1-like member Z, VH1-like phosphatase Z, low-molecular-mass dual-specificity phosphatase 3, testicular tissue protein Li 59
Species: human
Products:     DUSP23

Top Publications

  1. Wu Q, Li Y, Gu S, Li N, Zheng D, Li D, et al. Molecular cloning and characterization of a novel dual-specificity phosphatase 23 gene from human fetal brain. Int J Biochem Cell Biol. 2004;36:1542-53 pubmed
    ..In this study, a novel human dual-specificity protein phosphatases gene named dual-specificity phosphatase 23 (DUSP23) was isolated by large-scale sequencing analysis of a human fetal brain cDNA library...
  2. Alonso A, Burkhalter S, Sasin J, Tautz L, Bogetz J, Huynh H, et al. The minimal essential core of a cysteine-based protein-tyrosine phosphatase revealed by a novel 16-kDa VH1-like phosphatase, VHZ. J Biol Chem. 2004;279:35768-74 pubmed
    ..The gene for VHZ, which we designate as DUSP25, is located on human chromosome 1q23.1 and consists of only two coding exons...
  3. Takagaki K, Satoh T, Tanuma N, Masuda K, Takekawa M, Shima H, et al. Characterization of a novel low-molecular-mass dual-specificity phosphatase-3 (LDP-3) that enhances activation of JNK and p38. Biochem J. 2004;383:447-55 pubmed
    ..4 M sorbitol. By screening with a variety of stimuli, we found that LDP-3 specifically enhances the osmotic stress-induced activation of JNK and p38. ..
  4. Frinhani R, de Carvalho M, Soma N. A PageRank-based heuristic for the minimization of open stacks problem. PLoS ONE. 2018;13:e0203076 pubmed publisher
    The minimization of open stacks problem (MOSP) aims to determine the ideal production sequence to optimize the occupation of physical space in manufacturing settings...
  5. Godovikova V, Goetting Minesky M, Timm J, Fenno J. Immunotopological Analysis of the Treponema denticola Major Surface Protein (Msp). J Bacteriol. 2019;201: pubmed publisher
    ..Its major surface protein Msp (or MOSP) comprises an oligomeric outer membrane-associated complex that binds fibronectin, has cytotoxic pore-forming ..
  6. Anand A, Ledoyt M, Karanian C, Luthra A, Koszelak Rosenblum M, Malkowski M, et al. Bipartite Topology of Treponema pallidum Repeat Proteins C/D and I: OUTER MEMBRANE INSERTION, TRIMERIZATION, AND PORIN FUNCTION REQUIRE A C-TERMINAL β-BARREL DOMAIN. J Biol Chem. 2015;290:12313-31 pubmed publisher
    ..contains N- and C-terminal domains (TprC(N) and TprC(C)) orthologous to regions in the major outer sheath protein (MOSP(N) and MOSP(C)) of Treponema denticola and that TprC(C) is solely responsible for β-barrel formation, ..
  7. Radford R, Rcom H cheo Gauthier A, Wong M, Eaton E, Quilty M, Blizzard C, et al. The degree of astrocyte activation in multiple system atrophy is inversely proportional to the distance to α-synuclein inclusions. Mol Cell Neurosci. 2015;65:68-81 pubmed publisher
    ..syn addition caused ERK-dependent activation of rat astrocytes and perinuclear α-syn inclusions in mature (MOSP-positive) rat oligodendrocytes...
  8. Jdanov D, Deev A, Jasilionis D, Shalnova S, Shkolnikova M, Shkolnikov V. Recalibration of the SCORE risk chart for the Russian population. Eur J Epidemiol. 2014;29:621-8 pubmed publisher
    ..Petersburg populations (SCORE-MoSP)...
  9. Kim S, Oh M, Lee K, Kim W, Oh K, Lee S, et al. Profiling analysis of protein tyrosine phosphatases during neuronal differentiation. Neurosci Lett. 2016;612:219-224 pubmed publisher
    ..In particular, it was found that dual-specific phosphatase23 (DUSP23) affected neuronal differentiation...

More Information


  1. Wu A, Tian C, Yan H, Jiao Y, Yan Q, Yang G, et al. Hierarchical MoS2@MoP core-shell heterojunction electrocatalysts for efficient hydrogen evolution reaction over a broad pH range. Nanoscale. 2016;8:11052-9 pubmed publisher
    ..In this study, hierarchical flower-like MoS2@MoP core-shell heterojunctions (HF-MoSP) are designed as a promising catalyst for HER over a broad pH range...
  2. GALLEGOS L, Ng M, Sowa M, Selfors L, White A, Zervantonakis I, et al. A protein interaction map for cell-cell adhesion regulators identifies DUSP23 as a novel phosphatase for β-catenin. Sci Rep. 2016;6:27114 pubmed publisher
    ..Mechanistic studies of one novel CCARP which links to multiple cell-cell adhesion proteins, the phosphatase DUSP23, revealed that it promotes dephosphorylation of β-catenin at Tyr 142 and enhances the interaction between α- ..
  3. St Denis N, Gupta G, Lin Z, Gonzalez Badillo B, Veri A, Knight J, et al. Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. Cell Rep. 2016;17:2488-2501 pubmed publisher
    ..in mitotic exit, CDC14A in regulating microtubule integrity, PTPRF in mitotic retraction fiber integrity, and DUSP23 in centriole duplication...
  4. Tang J, Tan C, Li J, Siddique M, Guo K, Chan S, et al. VHZ is a novel centrosomal phosphatase associated with cell growth and human primary cancers. Mol Cancer. 2010;9:128 pubmed publisher
    VHZ is a VH1-like (member Z) dual specific protein phosphatase encoded by DUSP23 gene. Some of the dual specific protein phosphatases (DSPs) play an important role in cell cycle control and have shown to be associated with carcinogenesis...
  5. Jeong D, Wei C, Ku B, Jeon T, Chien P, Kim J, et al. The family-wide structure and function of human dual-specificity protein phosphatases. Acta Crystallogr D Biol Crystallogr. 2014;70:421-35 pubmed publisher
    ..The family-wide structures of DUSPs form a basis for the understanding of phosphorylation-mediated signal transduction and the development of therapeutics. ..
  6. Reiner A, Beleza S, Franceschini N, Auer P, Robinson J, Kooperberg C, et al. Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women. Am J Hum Genet. 2012;91:502-12 pubmed publisher
    ..The genetic architecture underlying the CRP phenotype in AA women is complex and involves genetic variants shared across populations, as well as variants specific to populations of African descent. ..
  7. Lin F, Chang C, Cheong M, Chen H, Lee D, Chang G, et al. Dual-specificity phosphatase 23 mediates GCM1 dephosphorylation and activation. Nucleic Acids Res. 2011;39:848-61 pubmed publisher
    ..Here we show that the interaction of GCM1 and dual-specificity phosphatase 23 (DUSP23) is enhanced by PKA-dependent phosphorylation of GCM1 on Ser269 and Ser275...
  8. Smith A, Rohrer B, Wheless L, Samantaray S, Ray S, Inoue J, et al. Calpain inhibition reduces structural and functional impairment of retinal ganglion cells in experimental optic neuritis. J Neurochem. 2016;139:270-284 pubmed publisher
    ..acuity and preserves retinal ganglion cells (Brn3a, brain-specific homeobox/POU domain protein 3A) and their axons (MOSP, myelin oligodendrocyte-specific protein)...
  9. Balada E, Felip L, Ordi Ros J, Vilardell Tarres M. DUSP23 is over-expressed and linked to the expression of DNMTs in CD4+ T cells from systemic lupus erythematosus patients. Clin Exp Immunol. 2017;187:242-250 pubmed publisher
    We evaluated the transcriptional expression of dual-specificity protein phosphatase 23 (DUSP23) in CD4+ T cells from 30 systemic lupus erythematosus (SLE) patients and 30 healthy controls...
  10. Nyberg F, Barratt B, Mushiroda T, Takahashi A, Jawaid A, Hada S, et al. Interstitial lung disease in gefitinib-treated Japanese patients with non-small-cell lung cancer: genome-wide analysis of genetic data. Pharmacogenomics. 2011;12:965-75 pubmed publisher
    ..Our top results may provide a useful hypothesis-generating starting point for further research. ..
  11. Puthenveetil R, Kumar S, Caimano M, Dey A, Anand A, Vinogradova O, et al. The major outer sheath protein forms distinct conformers and multimeric complexes in the outer membrane and periplasm of Treponema denticola. Sci Rep. 2017;7:13260 pubmed publisher
    The major outer sheath protein (MOSP) is a prominent constituent of the cell envelope of Treponema denticola (TDE) and one of its principal virulence determinants...
  12. Friedberg I, Nika K, Tautz L, Saito K, Cerignoli F, Friedberg I, et al. Identification and characterization of DUSP27, a novel dual-specific protein phosphatase. FEBS Lett. 2007;581:2527-33 pubmed
    ..DUSP27 is an active enzyme, and its kinetic parameters and were determined. DUSP27 is a cytosolic enzyme, expressed in skeletal muscle, liver and adipose tissue, suggesting its possible role in energy metabolism. ..