DUSP22

Summary

Gene Symbol: DUSP22
Description: dual specificity phosphatase 22
Alias: JKAP, JSP-1, JSP1, LMW-DSP2, LMWDSP2, MKP-x, MKPX, VHX, dual specificity protein phosphatase 22, JNK-stimulating phosphatase 1, JNK-stimulatory phosphatase-1, MAP kinase phosphatase x, homolog of mouse dual specificity phosphatase LMW-DSP2, low molecular weight dual specificity phosphatase 2, mitogen-activated protein kinase phosphatase x
Species: human
Products:     DUSP22

Top Publications

  1. Smith A, Price C, Cullen M, Muda M, King A, Ozanne B, et al. Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7). Genomics. 1997;42:524-7 pubmed
    ..The genes were localized to three different chromosomes, MKP2 (DUSP4) to 8p11-p12, MKP3 (DUSP6) to 12q22-q23, and MKPX (DUSP7) to 3p21. This will allow the potential roles of these genes in disease processes to be evaluated.
  2. Chen A, Zhou G, Juan T, Colicos S, Cannon J, Cabriera Hansen M, et al. The dual specificity JKAP specifically activates the c-Jun N-terminal kinase pathway. J Biol Chem. 2002;277:36592-601 pubmed
    ..We report the cloning and characterization of a murine DSP, called JNK pathway-associated phosphatase (JKAP), which lacks the regulatory region present in most other MAP kinase phosphatases (MKPs) and is preferentially ..
  3. Zhao X, Huang C, Wang R, Wang S. DUSP22 promotes senescence of HS-1 skin cancer cells through triggering MAPK signaling pathway. Eur Rev Med Pharmacol Sci. 2018;22:7819-7825 pubmed publisher
    Skin cancer severely threatens the public health. Dual-specificity protein phosphatase 22 (DUSP22) characterizes with multiple roles regulating cell growth, proliferation and gaining...
  4. Wang R, Sakata S, Chen B, Chang S, Hsieh P, Yang C, et al. Mycosis fungoides in Taiwan shows a relatively high frequency of large cell transformation and CD56 expression. Pathology. 2018;50:718-724 pubmed publisher
    ..immunohistochemistry, in situ hybridisation for EBV (EBER), and fluorescence in situ hybridisation (FISH) for DUSP22/MUM1 gene translocation...
  5. Shustov A, Soma L. Anaplastic Large Cell Lymphoma: Contemporary Concepts and Optimal Management. Cancer Treat Res. 2019;176:127-144 pubmed publisher
    ..e., International Prognostic Index, IPI) define the outcome in both subtypes. Molecular events affecting DUSP22 and TP63 have been reported to predict survival outcomes as well, with former being favorable, and the latter an ..
  6. Terao C, Yoshifuji H, Matsumura T, Naruse T, Ishii T, Nakaoka Y, et al. Genetic determinants and an epistasis of LILRA3 and HLA-B*52 in Takayasu arteritis. Proc Natl Acad Sci U S A. 2018;115:13045-13050 pubmed publisher
    ..loci, namely rs2322599, rs103294, rs17133698, and rs1713450, in PTK2B, LILRA3/LILRB2, DUSP22, and KLHL33, respectively...
  7. Luchtel R, Dasari S, Oishi N, Pedersen M, Hu G, Rech K, et al. Molecular profiling reveals immunogenic cues in anaplastic large cell lymphomas with DUSP22 rearrangements. Blood. 2018;: pubmed publisher
    ..About 30% of ALK-negative ALCLs have rearrangements of DUSP22 and have excellent long-term outcomes with standard therapy...
  8. Boks M, Houtepen L, Xu Z, He Y, Ursini G, Maihofer A, et al. Genetic vulnerability to DUSP22 promoter hypermethylation is involved in the relation between in utero famine exposure and schizophrenia. NPJ Schizophr. 2018;4:16 pubmed publisher
    ..schizophrenia patients, we found significant hypermethylation of the dual specificity phosphatase 22 (DUSP22) gene promoter (Chr6:291687-293285) (N?=?153, p?=?0.01)...
  9. Fauconneau A, Pham Ledard A, Cappellen D, Frison E, Prochazkova Carlotti M, Parrens M, et al. Assessment of diagnostic criteria between primary cutaneous anaplastic large-cell lymphoma and CD30-rich transformed mycosis fungoides; a study of 66 cases. Br J Dermatol. 2015;172:1547-1554 pubmed publisher
    ..b>DUSP22 gene rearrangement had no diagnostic or prognostic value...

More Information

Publications38

  1. Hamada N, Mizuno M, Tomita H, Iwamoto I, Hara A, Nagata K. Expression analyses of Dusp22 (Dual-specificity phosphatase 22) in mouse tissues. Med Mol Morphol. 2018;51:111-117 pubmed publisher
    b>Dusp22 (dual-specificity phosphatase 22) is considered to regulate various cellular processes through the regulation of protein dephosphorylation...
  2. Sakata Yanagimoto M, Chiba S. Molecular Pathogenesis of Peripheral T Cell Lymphoma. Curr Hematol Malig Rep. 2015;10:429-37 pubmed publisher
    ..in angioimmunoblastic T cell lymphoma (AITL), and recurrent translocations at the dual specificity phosphatase 22 (DUSP22) locus in anaplastic lymphoma receptor tyrosine kinase (ALK)-negative anaplastic large cell lymphomas (ALCLs)...
  3. Wang X, Boddicker R, Dasari S, Sidhu J, Kadin M, Macon W, et al. Expression of p63 protein in anaplastic large cell lymphoma: implications for genetic subtyping. Hum Pathol. 2017;64:19-27 pubmed publisher
    ..0001). Extra copies of TP63 correlated with extra copies of the DUSP22 locus on 6p25.3 (P<.0001)...
  4. Miura R, Araki A, Miyashita C, Kobayashi S, Kobayashi S, Wang S, et al. An epigenome-wide study of cord blood DNA methylations in relation to prenatal perfluoroalkyl substance exposure: The Hokkaido study. Environ Int. 2018;115:21-28 pubmed publisher
    ..were associated with exposure to PFOS and PFOA, in addition to ZFP57, DMRs in the CYP2E1, SMAD3, SLC17A9, GFPT2, DUSP22, and TCERG1L genes showed the same direction of effect in the replication cohort...
  5. Azar B, Eckert S, Kunkela J, Ingr T, Mounajjed R. The marginal fit of lithium disilicate crowns: Press vs. CAD/CAM. Braz Oral Res. 2018;32:e001 pubmed publisher
    ..The marginal gap was measured using optical microscope at 200× magnification (Keyence VHX-5000, Japan). Statistical analysis was performed using Wilcoxon test...
  6. Zhao B, Keasey S, Tropea J, Lountos G, Dyas B, Cherry S, et al. Phosphotyrosine Substrate Sequence Motifs for Dual Specificity Phosphatases. PLoS ONE. 2015;10:e0134984 pubmed publisher
    ..of peptide substrates with select DUSPs of four types: MAP kinases (DUSP1 and DUSP7), atypical (DUSP3, DUSP14, DUSP22 and DUSP27), viral (variola VH1), and Cdc25 (A-C)...
  7. Bian D, Zhang Y, Ji L. Microdytes huangyongensis sp. n. and new records of Allopachria Zimmermann, 1924 from Zhejiang Province, China (Coleoptera: Dytiscidae). Zootaxa. 2015;4040:469-71 pubmed publisher
    ..The photograph of the holotype (Fig 1) was made with a KEYENCE VHX-2000 C digital microscope...
  8. Pratt B, Zion D, Lwin K, Cheah P, Nosten F, Loff B. Closing the translation gap for justice requirements in international research. J Med Ethics. 2012;38:552-8 pubmed publisher
    ..describe how such methods have been used in relation to the Shoklo Malaria Research Unit's vivax malaria treatment (VHX) trial (NCT01074905)...
  9. Sekine Y, Tsuji S, Ikeda O, Sato N, Aoki N, Aoyama K, et al. Regulation of STAT3-mediated signaling by LMW-DSP2. Oncogene. 2006;25:5801-6 pubmed
    ..These results strongly suggest that LMW-DSP2 acts as a negative regulator of the IL-6/LIF/STAT3-mediated signaling pathway. ..
  10. King R, Dao L, McPhail E, Jaffe E, Said J, Swerdlow S, et al. Morphologic Features of ALK-negative Anaplastic Large Cell Lymphomas With DUSP22 Rearrangements. Am J Surg Pathol. 2016;40:36-43 pubmed publisher
    ..The largest subset, representing 30% of cases, had rearrangements of the DUSP22 locus. These cases had favorable outcomes similar to ALK-positive ALCL, and superior to other ALK-negative ALCLs...
  11. Sánchez Mut J, Aso E, Heyn H, Matsuda T, Bock C, Ferrer I, et al. Promoter hypermethylation of the phosphatase DUSP22 mediates PKA-dependent TAU phosphorylation and CREB activation in Alzheimer's disease. Hippocampus. 2014;24:363-8 pubmed publisher
    ..and patients, we have identified the presence of promoter hypermethylation of the dual-specificity phosphatase 22 (DUSP22) gene in AD...
  12. Guo C, Zhu X. Effect of ultrasound on dynamics characteristic of the cavitation bubble in grinding fluids during honing process. Ultrasonics. 2018;84:13-24 pubmed publisher
    ..The grinding fluid on the surface of the honing stone was measured by utilizing the digital microscope VHX-600ESO...
  13. Feldman A, Dogan A, Smith D, Law M, Ansell S, Johnson S, et al. Discovery of recurrent t(6;7)(p25.3;q32.3) translocations in ALK-negative anaplastic large cell lymphomas by massively parallel genomic sequencing. Blood. 2011;117:915-9 pubmed publisher
    ..We identified a balanced translocation disrupting the DUSP22 phosphatase gene on 6p25.3 and adjoining the FRA7H fragile site on 7q32.3 in a systemic ALK-negative ALCL...
  14. Shen Y, Luche R, Wei B, Gordon M, Diltz C, Tonks N. Activation of the Jnk signaling pathway by a dual-specificity phosphatase, JSP-1. Proc Natl Acad Sci U S A. 2001;98:13613-8 pubmed
  15. Boddicker R, Feldman A. Progress in the identification of subgroups in ALK-negative anaplastic large-cell lymphoma. Biomark Med. 2015;9:719-22 pubmed publisher
  16. Yokota T, Nara Y, Kashima A, Matsubara K, Misawa S, Kato R, et al. Crystal structure of human dual specificity phosphatase, JNK stimulatory phosphatase-1, at 1.5 A resolution. Proteins. 2007;66:272-8 pubmed
    ..JSP-1 has no loop corresponding to the Lys120-loop of PTP1B, and tryptophan residue corresponding to the substrate-stacking in PTP1B is substituted by alanine residue in JSP-1. ..
  17. Li J, Fu Y, Chen Y, Tan T. JNK pathway-associated phosphatase dephosphorylates focal adhesion kinase and suppresses cell migration. J Biol Chem. 2010;285:5472-8 pubmed publisher
    JNK pathway-associated phosphatase (JKAP, also named DUSP22) is expressed in various tissues, indicating that JKAP may have an important biological function. We showed that JKAP localized in the actin filament-enriched region...
  18. Lee Y, Takata K, Wang R, Yang S, Chuang S. Primary gastrointestinal anaplastic large cell lymphoma. Pathology. 2017;49:479-485 pubmed publisher
    ..By in situ hybridisation, all cases were negative for Epstein-Barr virus and for DUSP22/IRF4 gene translocation. At a median follow-up time of 37...
  19. Chuang H, Chen Y, Hung W, Li J, Chen D, Lan J, et al. Downregulation of the phosphatase JKAP/DUSP22 in T cells as a potential new biomarker of systemic lupus erythematosus nephritis. Oncotarget. 2016;7:57593-57605 pubmed publisher
    ..Our previous study indicates that JKAP (also named DUSP22) inhibits T-cell activation and that JKAP knockout mice develop spontaneous autoimmunity; therefore, we ..
  20. Sekine Y, Ikeda O, Hayakawa Y, Tsuji S, Imoto S, Aoki N, et al. DUSP22/LMW-DSP2 regulates estrogen receptor-alpha-mediated signaling through dephosphorylation of Ser-118. Oncogene. 2007;26:6038-49 pubmed
    In the previous study, we demonstrated the involvement of dual specificity phosphatase 22 (DUSP22/LMW-DSP2) in regulating the leukemia inhibitory factor/interleukin-6/signal transducer and activator of transcription 3-mediated signaling ..
  21. Arruga F, Gizdić B, Bologna C, Cignetto S, Buonincontri R, Serra S, et al. Mutations in NOTCH1 PEST domain orchestrate CCL19-driven homing of chronic lymphocytic leukemia cells by modulating the tumor suppressor gene DUSP22. Leukemia. 2017;31:1882-1893 pubmed publisher
    ..that NOTCH1 regulates growth and homing of CLL cells by dictating expression levels of the tumor suppressor gene DUSP22. Specifically, NOTCH1 affects the methylation of DUSP22 promoter by modulating a nuclear complex, which tunes the ..
  22. Ouyang B, Baxter C, Lam H, Yeramaneni S, Levin L, Haynes E, et al. Hypomethylation of dual specificity phosphatase 22 promoter correlates with duration of service in firefighters and is inducible by low-dose benzo[a]pyrene. J Occup Environ Med. 2012;54:774-80 pubmed publisher
    ..Cumulative occupational exposure to combustion-derived PAHs during firefighting can cause epigenetic changes in promoters of specific genes. ..
  23. Alonso A, Merlo J, Na S, Kholod N, Jaroszewski L, Kharitonenkov A, et al. Inhibition of T cell antigen receptor signaling by VHR-related MKPX (VHX), a new dual specificity phosphatase related to VH1 related (VHR). J Biol Chem. 2002;277:5524-8 pubmed
    ..Expression VHR-related MKPX (VHX) was highest in thymus, but also detectable in monocytes and lymphocytes...
  24. Xing X, Flotte T, Law M, Blahnik A, Chng W, Huang G, et al. Expression of the chemokine receptor gene, CCR8, is associated With DUSP22 rearrangements in anaplastic large cell lymphoma. Appl Immunohistochem Mol Morphol. 2015;23:580-9 pubmed publisher
    ..We recently identified recurrent rearrangements of the DUSP22 locus on 6p25.3 in both primary cutaneous and systemic ALK-negative ALCLs...
  25. Csikesz C, Knudson R, Greipp P, Feldman A, Kadin M. Primary cutaneous CD30-positive T-cell lymphoproliferative disorders with biallelic rearrangements of DUSP22. J Invest Dermatol. 2013;133:1680-2 pubmed publisher
  26. Lountos G, Cherry S, Tropea J, Waugh D. Structural analysis of human dual-specificity phosphatase 22 complexed with a phosphotyrosine-like substrate. Acta Crystallogr F Struct Biol Commun. 2015;71:199-205 pubmed publisher
    ..the first crystal structure is presented of a dual-specificity phosphatase, human dual-specificity phosphatase 22 (DUSP22), in complex with pNPP...
  27. Alonso A, Narisawa S, Bogetz J, Tautz L, Hadzic R, Huynh H, et al. VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX. J Biol Chem. 2004;279:32586-91 pubmed
    ..Similar to VHR-related MKPX (VHX) (DUSP22), the predicted protein has an N-terminal myristoylation recognition sequence, and we show here that both are ..
  28. Yu D, Li Z, Gan M, Zhang H, Yin X, Tang S, et al. Decreased expression of dual specificity phosphatase 22 in colorectal cancer and its potential prognostic relevance for stage IV CRC patients. Tumour Biol. 2015;36:8531-5 pubmed publisher
    Dual specificity phosphatase 22 (DUSP22) is a novel dual specificity phosphatase that has been demonstrated to be a cancer suppressor gene associated with numerous biological and pathological processes...
  29. Mélard P, Idrissi Y, Andrique L, Poglio S, Prochazkova Carlotti M, Berhouet S, et al. Molecular alterations and tumor suppressive function of the DUSP22 (Dual Specificity Phosphatase 22) gene in peripheral T-cell lymphoma subtypes. Oncotarget. 2016;7:68734-68748 pubmed publisher
    Monoallelic 6p25.3 rearrangements associated with DUSP22 (Dual Specificity Phosphatase 22) gene silencing have been reported in CD30+ peripheral T-cell lymphomas (PTCL), mostly with anaplastic morphology and of cutaneous origin...