DUSP2

Summary

Gene Symbol: DUSP2
Description: dual specificity phosphatase 2
Alias: PAC-1, PAC1, dual specificity protein phosphatase 2, dual specificity protein phosphatase PAC-1, serine/threonine specific protein phosphatase
Species: human
Products:     DUSP2

Top Publications

  1. Lin S, Chien C, Lee J, Yeh Y, Hsu K, Lai Y, et al. Suppression of dual-specificity phosphatase-2 by hypoxia increases chemoresistance and malignancy in human cancer cells. J Clin Invest. 2011;121:1905-16 pubmed publisher
    ..Here, we show that expression of the MAPK-specific phosphatase dual-specificity phosphatase-2 (DUSP2) is markedly reduced or completely absent in many human cancers and that its level of expression inversely ..
  2. Ergang P, Vodička M, Soták M, Klusoňová P, Behuliak M, Řeháková L, et al. Differential impact of stress on hypothalamic-pituitary-adrenal axis: gene expression changes in Lewis and Fisher rats. Psychoneuroendocrinology. 2015;53:49-59 pubmed publisher
    ..The upregulation of PACAP and CRH was paralleled only by increased expression of PACAP receptor PAC1 but not CRH receptor type 1...
  3. Telegdy G, Adamik A. Neurotransmitter-mediated anxiogenic action of PACAP-38 in rats. Behav Brain Res. 2015;281:333-8 pubmed publisher
    ..The receptor antagonist PACAP 6-38 (a PAC 1/VPAC2 receptor antagonist of PACAP-38 receptor), haloperidol (a non-selective dopamine receptor antagonist), ..
  4. Scarsini R, Prioli M, Milano E, Castellani C, Pesarini G, Assael B, et al. Hemodynamic predictors of long term survival in end stage cystic fibrosis. Int J Cardiol. 2016;202:221-5 pubmed publisher
    ..44: 95% CI 1.51-7.85: p=0.003). Impaired PAC is associated with poor prognosis in CF patients awaiting lung transplantation. Other traditional hemodynamic parameters add no prognostic information. ..
  5. Andres O, Henning K, Strauß G, Pflug A, Manukjan G, Schulze H. Diagnosis of platelet function disorders: A standardized, rational, and modular flow cytometric approach. Platelets. 2017;:1-10 pubmed publisher
  6. Yao Y, Chen Y, Adili R, McKeown T, Chen P, Zhu G, et al. Plant-based Food Cyanidin-3-Glucoside Modulates Human Platelet Glycoprotein VI Signaling and Inhibits Platelet Activation and Thrombus Formation. J Nutr. 2017;147:1917-1925 pubmed publisher
    ..Supplementation of Cy-3-g may have protective effects against atherothrombosis. ..
  7. Zhao C, Kodama Y, Flatberg A, Beisvag V, Kulseng B, Sandvik A, et al. Gene expression profiling of gastric mucosa in mice lacking CCK and gastrin receptors. Regul Pept. 2014;192-193:35-44 pubmed publisher
    ..was associated with an up-regulated pituitary adenylate cyclase-activating polypeptide (PACAP) type 1 receptor (PAC1)...
  8. Rigg R, Healy L, Nowak M, Mallet J, Thierheimer M, Pang J, et al. Heat shock protein 70 regulates platelet integrin activation, granule secretion and aggregation. Am J Physiol Cell Physiol. 2016;310:C568-75 pubmed publisher
  9. Levin C, Koren A, Pretorius E, Rosenberg N, Shenkman B, Hauschner H, et al. Deleterious mutation in the FYB gene is associated with congenital autosomal recessive small-platelet thrombocytopenia. J Thromb Haemost. 2015;13:1285-92 pubmed publisher
    ..The described phenotype shows ADAP to be important for normal platelet production, morphologic changes, and function. It is suggested that mutation analysis of this gene be included in the diagnosis of inherited thrombocytopenia. ..

More Information

Publications122 found, 100 shown here

  1. Mahata M, Zhang K, Gayen J, Nandi S, Brar B, Ghosh S, et al. Catecholamine biosynthesis and secretion: physiological and pharmacological effects of secretin. Cell Tissue Res. 2011;345:87-102 pubmed publisher
    ..PC12 cells, but this was inhibited by pre-treatment with VIP-preferring receptor (VPAC1)/PACAP-preferring receptor (PAC1) antagonists...
  2. Martínez Sánchez S, Minguela A, Prieto Merino D, Zafrilla Rentero M, Abellán Alemán J, Montoro García S. The Effect of Regular Intake of Dry-Cured Ham Rich in Bioactive Peptides on Inflammation, Platelet and Monocyte Activation Markers in Humans. Nutrients. 2017;9: pubmed publisher
    ..This study strongly suggests the existence of a mechanism that links dietary biopeptides and beneficial health effects. ..
  3. Gajewska A, Zielińska Górska M, Wolinska Witort E, Siawrys G, Baran M, Kotarba G, et al. Intracellular mechanisms involved in copper-gonadotropin-releasing hormone (Cu-GnRH) complex-induced cAMP/PKA signaling in female rat anterior pituitary cells in vitro. Brain Res Bull. 2016;120:75-82 pubmed publisher
  4. Qadri I, Hu L, Iwahashi M, Al Zuabi S, Quattrochi L, Simon F. Interaction of hepatocyte nuclear factors in transcriptional regulation of tissue specific hormonal expression of human multidrug resistance-associated protein 2 (abcc2). Toxicol Appl Pharmacol. 2009;234:281-92 pubmed publisher
    ..The coordinated regulation of xenobiotic transporters and oxidative conjugation may determine the adaptive responses to cellular detoxification processes...
  5. Hsia C, Velusamy M, Sheu J, Khamrang T, Jayakumar T, Lu W, et al. A novel ruthenium (II)-derived organometallic compound, TQ-6, potently inhibits platelet aggregation: Ex vivo and in vivo studies. Sci Rep. 2017;7:9556 pubmed publisher
    ..Therefore, TQ-6 has potential to develop as a therapeutic agent for preventing or treating thromboembolic disorders. ..
  6. Missig G, Mei L, Vizzard M, Braas K, Waschek J, Ressler K, et al. Parabrachial Pituitary Adenylate Cyclase-Activating Polypeptide Activation of Amygdala Endosomal Extracellular Signal-Regulated Kinase Signaling Regulates the Emotional Component of Pain. Biol Psychiatry. 2017;81:671-682 pubmed publisher
    ..Pituitary adenylate cyclase-activating polypeptide (PACAP; Adcyap1) and its cognate PAC1 receptor (Adcyap1r1) are expressed in peripheral nociceptive pathways, participate in anxiety-related responses and ..
  7. Kimmelstiel C, Stevenson R, Nguyen N, Van Doren L, Zhang P, Perkins J, et al. Enhanced potency of prasugrel on protease-activated receptors following bivalirudin treatment for PCI as compared to clopidogrel. Thromb Res. 2019;177:59-69 pubmed publisher
    ..These data identify a PAR4-dependent inhibitory mechanism for the prasugrel-mediated platelet inhibition, not seen with clopidogrel that could explain the reduction in stent thrombosis documented in clinical trials with prasugrel. ..
  8. Cline D, Short L, Forster M, Gray S. Adipose Tissue Expression of PACAP, VIP, and Their Receptors in Response to Cold Stress. J Mol Neurosci. 2018;: pubmed publisher
    ..We identified PACAP receptor (PAC1, VPAC1/2) expression for the first time in murine BAT and confirmed their expression in white adipose tissues...
  9. Higa T, Takahashi H, Higa Nakamine S, Suzuki M, Yamamoto H. Up-regulation of DUSP5 and DUSP6 by gonadotropin-releasing hormone in cultured hypothalamic neurons, GT1-7 cells. Biomed Res. 2018;39:149-158 pubmed publisher
    ..These up-regulated genes included four dual-specificity MAPK phosphatases (DUSPs), DUSP1, DUSP2, DUSP5, and DUSP6...
  10. Zhao Q, Li M, Chen M, Zhou L, Zhao L, Hu R, et al. Lovastatin induces platelet apoptosis. Environ Toxicol Pharmacol. 2016;42:69-75 pubmed publisher
    ..Lovastatin does not incur platelet activation, whereas impairs platelet function and reduces circulating platelets in vivo, suggesting the possible pathogenesis of thrombocytopenia and hemorrhage in patients treated with statins. ..
  11. Wang B, Peng Y, Dong J, Lin J, Wu C, Su Y, et al. Human platelets express functional thymic stromal lymphopoietin receptors: a potential role in platelet activation in acute coronary syndrome. Cell Physiol Biochem. 2013;32:1741-50 pubmed publisher
    ..In coronary disease patients, the determination of TSLPR in platelets may help to identify the risk of ACS. ..
  12. Lee W, Ku S, Kim M, Bae J. Anti-factor Xa activities of zingerone with anti-platelet aggregation activity. Food Chem Toxicol. 2017;105:186-193 pubmed publisher
    ..Collectively, these results show that ZGR could serve as candidates and provide scaffolds for the development of new anti-FXa and anti-platelet drugs. ..
  13. Li S, Hao G, Li J, Peng W, Geng X, Sun J. Comparative analysis of dual specificity protein phosphatase genes 1, 2 and 5 in response to immune challenges in Japanese flounder Paralichthys olivaceus. Fish Shellfish Immunol. 2017;68:368-376 pubmed publisher
    ..are detected in all examined Japanese flounder tissues; however, DUSP1 is dominantly expressed in spleen while DUSP2 and 5 are primarily expressed in skin...
  14. Mills B, Albert G, Halterman M. Expression Profiling of the MAP Kinase Phosphatase Family Reveals a Role for DUSP1 in the Glioblastoma Stem Cell Niche. Cancer Microenviron. 2017;10:57-68 pubmed publisher
    ..of the REpository for Molecular BRAin Neoplasia DaTa (REMBRANDT) revealed induction (DUSP4, DUSP6), repression (DUSP2, DUSP7-9), or mixed (DUSP1, DUSP5, DUSP10, DUSP15) DUSP transcription of select DUSPs in bulk tumor specimens...
  15. Gupte R, Kadunganattil S, Shepherd A, Merrill R, Planer W, Bruchas M, et al. Convergent phosphomodulation of the major neuronal dendritic potassium channel Kv4.2 by pituitary adenylate cyclase-activating polypeptide. Neuropharmacology. 2016;101:291-308 pubmed publisher
    ..cloned and characterized the downstream signaling originating from the activation of three PACAP receptor (PAC1) isoforms that are expressed in rodent hippocampal neurons that also exhibit abundant expression of Kv4.2 protein...
  16. Lee W, Kim M, Park I, Hwang J, Na M, Bae J. Novel direct factor Xa inhibitory compounds from Tenebrio molitor with anti-platelet aggregation activity. Food Chem Toxicol. 2017;109:19-27 pubmed publisher
    ..Therefore, 1-2 could serve as candidates and provide scaffolds for the development of new anti-FXa and anti-platelet drugs. ..
  17. Saito Y, Ohtani T, Kioka H, Onishi T, Tsukamoto Y, Nakamoto K, et al. Clinical Significance of Pulmonary Arterial Capacitance Calculated by Echocardiography in Patients With Advanced Heart Failure. Circ J. 2017;81:1871-1878 pubmed publisher
    ..94 mL/mmHg. They also had a significantly higher rate of ventricular assist device implantation or death, even after adjustment for indices related to HF severity or RV function during a 1-year follow-up period (P<0.01)...
  18. Fejes A, Best M, van der Heijden W, Vancura A, Verschueren H, de Mast Q, et al. Impact of Escherichia coli K12 and O18:K1 on human platelets: Differential effects on platelet activation, RNAs and proteins. Sci Rep. 2018;8:16145 pubmed publisher
    ..Our results demonstrate that different E. coli strains influence activation, RNA and protein levels differently which may affect platelet-bacteria crosstalk. ..
  19. Gorgoglione B, Carpio Y, Secombes C, Taylor N, Lugo J, Estrada M. Viral and bacterial septicaemic infections modulate the expression of PACAP splicing variants and VIP/PACAP receptors in brown trout immune organs. Fish Shellfish Immunol. 2015;47:923-32 pubmed publisher
    ..However, further experimental evidence is still required to fully elucidate and characterize the role of PACAP and PRP for an efficient immune response against pathogens. ..
  20. Qiao J, Wu Y, Liu Y, Li X, Wu X, Liu N, et al. Busulfan Triggers Intrinsic Mitochondrial-Dependent Platelet Apoptosis Independent of Platelet Activation. Biol Blood Marrow Transplant. 2016;22:1565-1572 pubmed publisher
    ..These data suggest targeting caspase activation might be beneficial in the prophylaxis of platelet apoptosis-associated thrombocytopenia after administration of busulfan. ..
  21. Ago Y, Hayata Takano A, Kawanai T, Yamauchi R, Takeuchi S, Cushman J, et al. Impaired extinction of cued fear memory and abnormal dendritic morphology in the prelimbic and infralimbic cortices in VPAC2 receptor (VIPR2)-deficient mice. Neurobiol Learn Mem. 2017;145:222-231 pubmed publisher
    ..Several bodies of research have shown the impact of the PACAP specific receptor PAC1 on fear memory, but the roles of other PACAP receptors in regulating fear stress responses remain to be elucidated...
  22. Chaurasiya S, Hew P, Crosley P, Sharon D, Potts K, Agopsowicz K, et al. Breast cancer gene therapy using an adenovirus encoding human IL-2 under control of mammaglobin promoter/enhancer sequences. Cancer Gene Ther. 2016;23:178-87 pubmed publisher
    ..Both IL-2 vectors exerted significant tumor growth delay; however, attempts to further enhance antitumor activity of the IL-2 vectors by combining with the proapoptotic drug procaspase activating compound 1 (PAC1) were unsuccessful.
  23. Iemolo A, Seiglie M, Blasio A, Cottone P, Sabino V. Pituitary adenylate cyclase-activating polypeptide (PACAP) in the central nucleus of the amygdala induces anxiety via melanocortin receptors. Psychopharmacology (Berl). 2016;233:3269-77 pubmed publisher
    ..The neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptor PAC1 (PAC1R) are highly expressed in the central nucleus of the amygdala (CeA), and they have gained growing attention ..
  24. Tan Y, Abad C, Wang Y, Lopez R, Waschek J. VPAC2 (vasoactive intestinal peptide receptor type 2) receptor deficient mice develop exacerbated experimental autoimmune encephalomyelitis with increased Th1/Th17 and reduced Th2/Treg responses. Brain Behav Immun. 2015;44:167-175 pubmed publisher
    ..what are the specific immunoregulatory roles played by each of their receptor subtypes (VPAC1, VPAC2, and PAC1) is critical...
  25. Lin C, Bai J, He M, Wong A. Grass Carp Prolactin Gene: Structural Characterization and Signal Transduction for PACAP-induced Prolactin Promoter Activity. Sci Rep. 2018;8:4655 pubmed publisher
    ..These results suggest that PACAP can stimulate PRL promoter activation by PAC1 mediated functional coupling of the Ca2+/CaM/CaM kinase II cascades with the AC/cAMP/PKA pathway...
  26. Gkourogianni A, Kiouptsi K, Koloka V, Moussis V, Tsikaris V, Bachelot Loza C, et al. Synergistic effect of peptide inhibitors derived from the extracellular and intracellular domain of ?IIb subunit of integrin ?IIb?3 on platelet activation and aggregation. Platelets. 2018;29:34-40 pubmed publisher
    ..We suggest that the use of the intracellular in combination with the extracellular peptide inhibitor, acting with a non-RGD-like mechanism, may provide an alternative way to antagonize integrin ?IIb?3 activation. ..
  27. Lebrun A, Moll Khosrawi P, Pohl S, Makrypidi G, Storch S, Kilian D, et al. Analysis of potential biomarkers and modifier genes affecting the clinical course of CLN3 disease. Mol Med. 2011;17:1253-61 pubmed publisher
    ..Of those, dual specificity phosphatase 2 (DUSP2) was also validated in acutely CLN3-depleted cell models and in CbCln3(?ex7/8) cerebellar precursor cells...
  28. Häkkinen M, Sivasiddarthan D, Aro N, Saloheimo M, Pakula T. The effects of extracellular pH and of the transcriptional regulator PACI on the transcriptome of Trichoderma reesei. Microb Cell Fact. 2015;14:63 pubmed publisher
    ..profiling and by analysing the effects of deletion of the gene encoding the transcriptional regulator pac1, the orthologue of Aspergillus nidulans pacC gene. Transcriptional analysis revealed the pH-responsive genes of T...
  29. Kuriyama N, Mizuno T, Yasuike H, Matsuno H, Kawashita E, Tamura A, et al. CD62-mediated activation of platelets in cerebral white matter lesions in patients with cognitive decline. Arch Gerontol Geriatr. 2016;62:118-24 pubmed publisher
    ..CD62P levels may be useful as a sensitive clinical marker for the early detection of DWMLs with cognitive decline. ..
  30. Algarni A, Hargreaves A, Dickenson J. Role of transglutaminase 2 in PAC1 receptor mediated protection against hypoxia-induced cell death and neurite outgrowth in differentiating N2a neuroblastoma cells. Biochem Pharmacol. 2017;128:55-73 pubmed publisher
    ..Furthermore, PAC1 receptor-induced cytoprotection and neurite outgrowth are dependent upon TG2. These results highlight the importance of TG2 in the cellular functions of the PAC1 receptor. ..
  31. Huang J, Waters K, Machaalani R. Pituitary adenylate cyclase activating polypeptide (PACAP) and its receptor 1 (PAC1) in the human infant brain and changes in the Sudden Infant Death Syndrome (SIDS). Neurobiol Dis. 2017;103:70-77 pubmed publisher
    Pituitary adenylate cyclase activating polypeptide (PACAP) and its complementary receptor, PAC1, are crucial in central respiratory control...
  32. Krajcs N, Hernádi L, Pirger Z, Reglődi D, Tóth G, Kiss T. PACAP Modulates Acetylcholine-Elicited Contractions at Nicotinic Neuromuscular Contacts of the Land Snail. J Mol Neurosci. 2015;57:492-500 pubmed publisher
    ..Using immunohistochemistry, we show that PACAP and PAC1 receptors are present in nerve fibers innervating the flexor muscles but not in the muscle itself...
  33. Juhász T, Szentléleky E, Somogyi C, Takács R, Dobrosi N, Engler M, et al. Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) Pathway Is Induced by Mechanical Load and Reduces the Activity of Hedgehog Signaling in Chondrogenic Micromass Cell Cultures. Int J Mol Sci. 2015;16:17344-67 pubmed publisher
    ..Expressions of the mRNAs of PACAP and its major receptor, PAC1 increased, while that of other receptors, VPAC1, VPAC2 decreased upon mechanical stimulus...
  34. Adnani L, Langevin L, Gautier E, Dixit R, Parsons K, Li S, et al. Zac1 Regulates the Differentiation and Migration of Neocortical Neurons via Pac1. J Neurosci. 2015;35:13430-47 pubmed publisher
    ..Finally, Zac1 controlled neuronal migration by regulating Pac1 transcription, a receptor for the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP)...
  35. Yang T, Li Y, Ma M, Lin Q, Sun S, Zhang B, et al. Protective effect of soluble eggshell membrane protein hydrolysate on cardiac ischemia/reperfusion injury. Food Nutr Res. 2015;59:28870 pubmed publisher
    ..This cardioprotective effect of SP2 suggested a novel therapeutic agent of SEP for ischemic-related heart diseases. ..
  36. Mo S, Liu X, Hao X, Chen W, Zhang K, Cai J, et al. EYA4 functions as tumor suppressor gene and prognostic marker in pancreatic ductal adenocarcinoma through ?-catenin/ID2 pathway. Cancer Lett. 2016;380:403-12 pubmed publisher
    ..We showed that EYA4 functioned as tumor suppressor gene in PDAC via repressing ?-catenin/ID2 activation, and was an independent prognostic factor in PDAC. ..
  37. Suntsova E, Demina I, Ignatova A, Ershov N, Trubina N, Dobrynina J, et al. Bleeding tendency and platelet function during treatment with romiplostim in children with severe immune thrombocytopenic purpura. Int J Hematol. 2017;105:841-848 pubmed publisher
    ..Levels of CD42b, PAC1, and CD62P, but not CD61 or annexin V, were significantly increased (P < 0...
  38. Huang J, Waters K, Machaalani R. Hypoxia and nicotine effects on Pituitary adenylate cyclase activating polypeptide (PACAP) and its receptor 1 (PAC1) in the developing piglet brainstem. Neurotoxicology. 2017;62:30-38 pubmed publisher
    Pituitary adenylate cyclase activating polypeptide (PACAP) and its cognate receptor 1 (PAC1), have been implicated in the pathophysiology of the Sudden Infant Death Syndrome (SIDS)...
  39. Yahata C, Mochizuki A. Platelet compatibility of magnesium alloys. Mater Sci Eng C Mater Biol Appl. 2017;78:1119-1124 pubmed publisher
    ..These results show that platelet activation is caused by an increase in pH at the alloy surface owing to the erosion of the alloy. ..
  40. Zhang Q, Ma J, Liu H, He D, Chen L, Wu H, et al. Comparative Analysis of Gene Expression Profiles of Human Dental Fluorosis and Kashin-Beck Disease. Sci Rep. 2018;8:170 pubmed publisher
    ..A total of 10 overlaps (DUSP2, KLRF1, SRP19, KLRC3, CD69, SIK1, ITGA4, ID3, HSPA1A, GPR18) were obtained between DEGs of patients with KBD and ..
  41. Ohnou T, Yokai M, Kurihara T, Hasegawa Moriyama M, Shimizu T, Inoue K, et al. Pituitary adenylate cyclase-activating polypeptide type 1 receptor signaling evokes long-lasting nociceptive behaviors through the activation of spinal astrocytes in mice. J Pharmacol Sci. 2016;130:194-203 pubmed publisher
    ..long-lasting nociceptive behaviors for more than 60 min in mice, while the involvement of PACAP type1 receptor (PAC1-R) has not been clarified yet...
  42. Chen Y, Sun M, Ding J, Zhu Q. SM-1, a novel PAC-1 derivative, activates procaspase-3 and causes cancer cell apoptosis. Cancer Chemother Pharmacol. 2016;78:643-54 pubmed publisher
    ..We identified SM-1 as a promising antitumor candidate, which displayed enhanced procaspase-3 activating activity and potent cytotoxicity for cancer cells but low toxicity for normal cells. ..
  43. Annarapu G, Singhal R, Gupta A, Chawla S, Batra H, Seth T, et al. HbS Binding to GP1b? Activates Platelets in Sickle Cell Disease. PLoS ONE. 2016;11:e0167899 pubmed publisher
    ..7 fold) and PAC1 binding (10.4 fold) in platelet surface in a concentration-dependent manner...
  44. Hardwick J, Clason T, Tompkins J, Girard B, Baran C, Merriam L, et al. Recruitment of endosomal signaling mediates the forskolin modulation of guinea pig cardiac neuron excitability. Am J Physiol Cell Physiol. 2017;313:C219-C227 pubmed publisher
    ..which is a major signaling mechanism for the pituitary adenylate cyclase-activating polypeptide (PACAP)-selective PAC1 receptor, in the regulation of guinea pig cardiac neuronal excitability...
  45. Lammers L, Markus S. The dynein cortical anchor Num1 activates dynein motility by relieving Pac1/LIS1-mediated inhibition. J Cell Biol. 2015;211:309-22 pubmed publisher
    ..Rather than walking toward minus ends, dynein remains associated with plus ends due in part to its association with Pac1/LIS1, an inhibitor of dynein motility...
  46. Liu W, Bai J, Guo Q, Huang Z, Yang H, Bai Y. Role of platelet function and platelet membrane glycoproteins in children with primary immune thrombocytopenia. Mol Med Rep. 2016;14:2052-60 pubmed publisher
    ..In conclusion, the activation of platelets in ITP children was low. Decreased platelet function, platelet parameters and platelet glycoproteins may be used as markers for monitoring the treatment efficacy in ITP children. ..
  47. Refsum E, Meinke S, Gryfelt G, Wikman A, Hoglund P. Adding to the complexity of fetal and neonatal alloimmune thrombocytopenia: Reduced fibrinogen binding in the presence of anti-HPA-1a antibody and hypo-responsive neonatal platelets. Thromb Res. 2018;162:69-76 pubmed publisher
    ..This effect may operate in parallel to platelet destruction and contribute to the clinical outcome in FNAIT. ..
  48. Zaman S, Wang R, Gandhi V. Targeting executioner procaspase-3 with the procaspase-activating compound B-PAC-1 induces apoptosis in multiple myeloma cells. Exp Hematol. 2015;43:951-962.e3 pubmed publisher
    ..This novel strategy has the potential to become an effective antimyeloma therapy. ..
  49. Marzagalli R, Leggio G, Bucolo C, Pricoco E, Keay K, Cardile V, et al. Genetic blockade of the dopamine D3 receptor enhances hippocampal expression of PACAP and receptors and alters their cortical distribution. Neuroscience. 2016;316:279-95 pubmed publisher
    ..Consistently, PAC1, VPAC1 and VPAC2 IRs were variably redistributed in CX, with a general upregulation in cortical layers II-IV in ..
  50. Xu Z, Ohtaki H, Watanabe J, Miyamoto K, Murai N, Sasaki S, et al. Pituitary adenylate cyclase-activating polypeptide (PACAP) contributes to the proliferation of hematopoietic progenitor cells in murine bone marrow via PACAP-specific receptor. Sci Rep. 2016;6:22373 pubmed publisher
    ..This study assessed the expression of a PACAP-specific receptor (PAC1) gene and protein in mouse bone marrow (BM)...
  51. Peh J, Fan T, Wycislo K, Roth H, Hergenrother P. The Combination of Vemurafenib and Procaspase-3 Activation Is Synergistic in Mutant BRAF Melanomas. Mol Cancer Ther. 2016;15:1859-69 pubmed publisher
    ..Mol Cancer Ther; 15(8); 1859-69. ©2016 AACR. ..
  52. Alberio L, Ravanat C, Hechler B, Mangin P, Lanza F, Gachet C. Delayed-onset of procoagulant signalling revealed by kinetic analysis of COAT platelet formation. Thromb Haemost. 2017;117:1101-1114 pubmed publisher
  53. Lu D, Liu L, Ji X, Gao Y, Chen X, Liu Y, et al. The phosphatase DUSP2 controls the activity of the transcription activator STAT3 and regulates TH17 differentiation. Nat Immunol. 2015;16:1263-73 pubmed publisher
    ..However, the mechanism by which TH17 cells are regulated remains elusive. Here we found that the phosphatase DUSP2 (PAC1) negatively regulated the development of TH17 cells...
  54. Schubert P, Coupland D, Nombalais M, M Walsh G, Devine D. RhoA/ROCK signaling contributes to sex differences in the activation of human platelets. Thromb Res. 2016;139:50-5 pubmed publisher
    ..males. The increased signaling activity in platelets from females mirrors their greater sensitivity to agonists. These findings further our understanding of the molecular differences between platelets from males and females. ..
  55. Vaczy A, Reglodi D, Somoskeoy T, Kovacs K, Lokos E, Szabo E, et al. The Protective Role of PAC1-Receptor Agonist Maxadilan in BCCAO-Induced Retinal Degeneration. J Mol Neurosci. 2016;60:186-94 pubmed publisher
    ..All three PACAP receptors (PAC1, VPAC1, VPAC2) appear in the retina...
  56. Robertson N, Yang Y, Khan I, LaMantia V, Royzen M, Yigit M. Single-trigger dual-responsive nanoparticles for controllable and sequential prodrug activation. Nanoscale. 2017;9:10020-10030 pubmed publisher
    ..Our nanodrug loaded with the slow-releasing doxorubicin and fast-releasing PAC-1 prodrugs displayed a greater therapeutic response than the nanodrug which released both payloads simultaneously. ..
  57. Mitsui C, Kajiwara K, Hayashi H, Ito J, Mita H, Ono E, et al. Platelet activation markers overexpressed specifically in patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2016;137:400-11 pubmed publisher
    ..Platelet activation was involved in cysteinyl leukotriene overproduction and persistent airflow limitations in patients with AERD. ..
  58. Joo S, Choi J, Kim S, Kim K, Kim Y, Kang S. An Assay of Measuring Platelet Reactivity Using Monoclonal Antibody against Activated Platelet Glycoprotein IIb/IIIa in Patients Taking Clopidogrel. Korean Circ J. 2015;45:378-85 pubmed publisher
    ..In this study, PAC1, a monoclonal antibody against activated platelet GP IIb/IIIa, was used to measure the residual platelet reactivity...
  59. Iwasa T, Matsuzaki T, Tungalagsuvd A, Munkhzaya M, Yiliyasi M, Kato T, et al. Developmental changes in the hypothalamic mRNA expression levels of PACAP and its receptor PAC1 and their sensitivity to fasting in male and female rats. Int J Dev Neurosci. 2016;52:33-7 pubmed publisher
    ..found to play pivotal roles in the regulation of metabolic and nutritional status through its specific receptor PAC1. PACAP/PAC1 have anorectic roles, and their functions are regulated by leptin in adulthood...
  60. Gajos K, Kamińska A, Awsiuk K, Bajor A, Gruszczyński K, Pawlak A, et al. Immobilization and detection of platelet-derived extracellular vesicles on functionalized silicon substrate: cytometric and spectrometric approach. Anal Bioanal Chem. 2017;409:1109-1119 pubmed publisher
    ..Immobilized PMVs can be subjected to label-free analyses by means ellipsometry, atomic force microscopy (AFM) and time-of-flight secondary ion mass spectrometry (TOF-SIMS). ..
  61. Reglodi D, Tamas A, Jungling A, Vaczy A, Rivnyak A, Fulop B, et al. Protective effects of pituitary adenylate cyclase activating polypeptide against neurotoxic agents. Neurotoxicology. 2018;66:185-194 pubmed publisher
    ..PACAP has been shown to activate several protective pathways, mainly through its specific PAC1 receptor and protein kinase A, C and MAP kinases downstream...
  62. Ma Y, Zhao S, Wang X, Shen S, Ma M, Xu W, et al. A New Recombinant PACAP-Derived Peptide Efficiently Promotes Corneal Wound Repairing and Lacrimal Secretion. Invest Ophthalmol Vis Sci. 2015;56:4336-49 pubmed publisher
    ..pituitary adenylate cyclase-activating polypeptide (PACAP)-derived peptide, MPAPO, which has higher stability and PAC1-specific potency, was generated...
  63. Ferguson B, Nam H, Stephens J, Morrison R. Mitogen-Dependent Regulation of DUSP1 Governs ERK and p38 Signaling During Early 3T3-L1 Adipocyte Differentiation. J Cell Physiol. 2016;231:1562-74 pubmed publisher
    ..In support of this, qRT-PCR identified several MAPK-specific DUSPs induced during early (DUSP2, -4, -5, & -6), mid (DUSP4 & -16) and late (DUSP9) stages of adipocyte differentiation...
  64. Zhang D, Zhang X, Liu D, Liu T, Cai W, Yan C, et al. Association between insulin receptor substrate-1 polymorphisms and high platelet reactivity with clopidogrel therapy in coronary artery disease patients with type 2 diabetes mellitus. Cardiovasc Diabetol. 2016;15:50 pubmed publisher
    ..8 ± 12.4 vs 36.2 ± 13.8, p = 0.01; 43.7 ± 15.9 vs 38.7 ± 19.9, p = 0.03, respectively). The G allele of rs13431554 in the IRS-1 gene was associated with a hyperreactive platelet phenotype in the CAD patients with T2DM. ..
  65. Chiva Blanch G, Crespo J, Suades R, Arderiu G, Padro T, Vilahur G, et al. CD142+/CD61+, CD146+ and CD45+ microparticles predict cardiovascular events in high risk patients following a Mediterranean diet supplemented with nuts. Thromb Haemost. 2016;116:103-14 pubmed publisher
  66. Agüero Chapin G, Pérez Machado G, Mull J, Ancede Gallardo E, Antunes A, Riva G. How the Protein Architecture of RNases III Influences their Substrate Specificity?. Curr Pharm Des. 2016;22:5065-5071 pubmed
    ..enzymatic activity of three RNase III members from class I (Escherichia coli RNase III, Schizosaccharomyces pombe Pac1 and Saccharomyces cerevisiae Rntp1) and the human Drosha placed in class II was revisited against four different ..
  67. Li L, Qu C, Wu X, Dai J, Lu Y, Gong Y, et al. Patterns and levels of platelet glycosylation in patients with coronary heart disease and type 2 diabetes mellitus. J Thromb Thrombolysis. 2018;45:56-65 pubmed publisher
    ..The changes of platelet glycosylation may be associated with high platelet reactivity and the increased risk of thrombosis in CHD and T2DM. ..
  68. Yi H, Morton C, Weremowicz S, McBride O, Kelly K. Genomic organization and chromosomal localization of the DUSP2 gene, encoding a MAP kinase phosphatase, to human 2p11.2-q11. Genomics. 1995;28:92-6 pubmed
    The mitogen-induced gene, DUSP2, encodes a nuclear protein, PAC1, that acts as a dual-specific protein phosphatase with stringent substrate specificity for MAP kinase...
  69. Martell K, Kwak S, Hakes D, Dixon J, Trent J. Chromosomal localization of four human VH1-like protein-tyrosine phosphatases. Genomics. 1994;22:462-4 pubmed
    ..The genes were localized to unique regions of different chromosomes: CL100, a stress-induced PTPase, to 5q35; PAC-1, a mitogen-induced nuclear PTPase, to 2q11;hVH-3 to 10q25; and hVH-4 to 10q11. ..
  70. Karakashev S, Reginato M. Hypoxia/HIF1α induces lapatinib resistance in ERBB2-positive breast cancer cells via regulation of DUSP2. Oncotarget. 2015;6:1967-80 pubmed
    ..bypass the lapatinib-treated inhibition of the ERK pathway via inhibition of the dual-specificity phosphatase 2 (DUSP2)...
  71. Han X, Ran Y, Su M, Liu Y, Tang W, Dong Z, et al. Chronic changes in pituitary adenylate cyclase-activating polypeptide and related receptors in response to repeated chemical dural stimulation in rats. Mol Pain. 2017;13:1744806917720361 pubmed publisher
    ..to measure the protein and mRNA expression of pituitary adenylate cyclase-activating polypeptide-related receptors (PAC1, VPAC1, and VPAC2) in the trigeminal ganglia and trigeminal nucleus caudalis to identify changes associated with ..
  72. Yin Y, Liu Y, Jin Y, Hall E, Barrett J. PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression. Nature. 2003;422:527-31 pubmed
    ..PAC1 (phosphatase of activated cells 1; also known as dual specificity phosphatase 2, DUSP2) is a dual threonine/tyrosine phosphatase that specifically dephosphorylates and inactivates mitogen-activated ..
  73. Kothapalli R, Yoder S, Kusmartseva I, Loughran T. Characterization of a variant of PAC-1 in large granular lymphocyte leukemia. Protein Expr Purif. 2003;32:52-60 pubmed
    ..The significance of the constitutive over-expression and its physiological role of this protein remain to be established in leukemic LGL. ..
  74. Lin S, Hsiao K, Chang N, Hou P, Tsai S. Loss of dual-specificity phosphatase-2 promotes angiogenesis and metastasis via up-regulation of interleukin-8 in colon cancer. J Pathol. 2017;241:638-648 pubmed publisher
    Dual-specificity phosphatase 2 (DUSP2) is a negative regulator of mitogen-activated protein kinases...
  75. Li W, Yang X, Peng M, Li C, Mu G, Chen F. Inhibitory effects of ethyl pyruvate on platelet aggregation and phosphatidylserine exposure. Biochem Biophys Res Commun. 2017;487:560-566 pubmed publisher
  76. Simon A, Oláh J, Komlósi I, Javor A, Nemeth J, Szilvassy Z, et al. Changes in expression of neuropeptides and their receptors in the hypothalamus and gastrointestinal tract of calorie restricted hens. Acta Biol Hung. 2017;68:237-247 pubmed publisher
    ..mRNA expression of the pituitary adenylate cyclase-activating polypeptide (PACAP), gene expression of its receptor (PAC1), furthermore the gene expression of galanin (GAL), neuromedin U (NMU), and its two receptors (NMUR1 and NMUR2) in ..
  77. Bhandare A, Kapoor K, Farnham M, Pilowsky P. Microglia PACAP and glutamate: Friends or foes in seizure-induced autonomic dysfunction and SUDEP?. Respir Physiol Neurobiol. 2016;226:39-50 pubmed publisher
    ..Seizure-induced increase in PACAP is neuroprotective. PACAP produces neuroprotective effects acting on microglial PAC1 and VPAC1 receptors...
  78. Bondu V, Wu C, Cao W, Simons P, Gillette J, Zhu J, et al. Low-affinity binding in cis to P2Y2R mediates force-dependent integrin activation during hantavirus infection. Mol Biol Cell. 2017;28:2887-2903 pubmed publisher
    ..recapitulates physiologic activation of the integrin as indicated by staining with the activation-specific mAB PAC1. The data also show that blocking of the Gα13 protein from binding to the cytoplasmic domain of the Î..
  79. Verma A, Manohar M, Upparahalli Venkateshaiah S, Mishra A. Neuroendocrine cells derived chemokine vasoactive intestinal polypeptide (VIP) in allergic diseases. Cytokine Growth Factor Rev. 2017;38:37-48 pubmed publisher
    ..VIP mediates immunological function through interaction with specific receptors namely VPAC-1, VPAC-2, CRTH2 and PAC1 that are expressed on several immune cells such as eosinophils, mast cells, neutrophils, and lymphocytes; therefore,..
  80. de Castro E, Reus T, de Aguiar A, Avila A, de Arruda Campos Brasil de Souza T. Procaspase-activating compound-1 induces apoptosis in Trypanosoma cruzi. Apoptosis. 2017;22:1564-1577 pubmed publisher
    ..These data are important for improving the understanding of the apoptosis pathway in T. cruzi so that TcMCA3 could be better targeted with future pharmaceuticals. ..
  81. Zhang Q, Muller M, Chen C, Zeng L, Farooq A, Zhou M. New insights into the catalytic activation of the MAPK phosphatase PAC-1 induced by its substrate MAPK ERK2 binding. J Mol Biol. 2005;354:777-88 pubmed
    ..These results suggest that Arg294 and Arg295 play an important role in PAC-1 catalytic activation induced by ERK2 binding. ..
  82. Caunt C, Rivers C, Conway Campbell B, Norman M, McArdle C. Epidermal growth factor receptor and protein kinase C signaling to ERK2: spatiotemporal regulation of ERK2 by dual specificity phosphatases. J Biol Chem. 2008;283:6241-52 pubmed publisher
    ..b>DUSP2 and -4 inactivate and anchor ERK2, whereas DUSP1 dephosphorylates ERK in the nucleus but allows its traffic back ..
  83. Kang J, Amar M, Remaley A, Kwon J, Blackshear P, Wang P, et al. Zinc finger protein tristetraprolin interacts with CCL3 mRNA and regulates tissue inflammation. J Immunol. 2011;187:2696-701 pubmed publisher
  84. Hannibal J, Georg B, Fahrenkrug J. PAC1- and VPAC2 receptors in light regulated behavior and physiology: Studies in single and double mutant mice. PLoS ONE. 2017;12:e0188166 pubmed publisher
    ..cyclase activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP) and their receptors, the PAC1 -and the VPAC2 receptors, are involved in regulation of the circadian timing system...
  85. Feher M, Gaszner B, Tamas A, Gil Martinez A, Fernandez Villalba E, Herrero M, et al. Alteration of the PAC1 Receptor Expression in the Basal Ganglia of MPTP-Induced Parkinsonian Macaque Monkeys. Neurotox Res. 2018;33:702-715 pubmed publisher
    ..PACAP exerts its protective actions via three G protein-coupled receptors: the specific Pac1 receptor (Pac1R) and the Vpac1/Vpac2 receptors, the neuroprotective effects being mainly mediated by the Pac1R...
  86. Raingeaud J, Gupta S, Rogers J, Dickens M, Han J, Ulevitch R, et al. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J Biol Chem. 1995;270:7420-6 pubmed
    ..Immunofluorescence microscopy demonstrated that p38 MAP kinase is present in both the nucleus and cytoplasm of activated cells. Together, these data establish that p38 is a member of the mammalian MAP kinase group. ..
  87. Wu J, Jin Y, Calaf G, Huang W, Yin Y. PAC1 is a direct transcription target of E2F-1 in apoptotic signaling. Oncogene. 2007;26:6526-35 pubmed
    ..In this paper, we report that phosphatase of activated cells 1 (PAC1) phosphatase is a direct transcription target of E2F-1 in signaling apoptosis...
  88. Lo K, Li Z, Wang F, Marcotte E, Johnson A. Ribosome stalk assembly requires the dual-specificity phosphatase Yvh1 for the exchange of Mrt4 with P0. J Cell Biol. 2009;186:849-62 pubmed publisher
    ..The initial assembly of the ribosome with Mrt4 may provide functional compartmentalization of ribosome assembly in addition to the spatial separation afforded by the nuclear envelope. ..
  89. Hou P, Li Y, Lin S, Lin S, Lee J, Lin B, et al. Hypoxia-Induced Downregulation of DUSP-2 Phosphatase Drives Colon Cancer Stemness. Cancer Res. 2017;77:4305-4316 pubmed publisher
    ..Here, we report that hypoxia-mediated downregulation of the dual specificity phosphatase 2 (DUSP2) is critical for the accumulation of CSC in colorectal cancer...
  90. Jiang Y, Li X, Wang H, Kang L, Zhu G, Zhuang W. [Influence of dipyridamole on expression of PAC-1 and CD62p in patients with malignant lymphoma]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010;18:923-6 pubmed
    ..Applying dipyridamole routine dosage in chemotherapy can efficiently restrain platelet activation. ..
  91. Wen W, Young S, Duvernay M, Schulte M, Nance K, Melancon B, et al. Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354. Bioorg Med Chem Lett. 2014;24:4708-4713 pubmed publisher
    ..Using a novel PAC-1 fluorescent αIIbβ3 activation assay this probe molecule antagonist was found to have an IC50 of 140nM for PAR-4 with 71-fold selectivity versus PAR-1 (PAR-1IC50=10μM). ..
  92. Wang D, Cai F, Ge J, Yin L. Brief Exercises Affect Gene Expression in Circulating Monocytes. Scand J Immunol. 2015;82:429-35 pubmed publisher
    ..Dual-specificity phosphatase 2 (DUSP2) was identified as a key node in the co-expression network...