Gene Symbol: DUSP19
Description: dual specificity phosphatase 19
Alias: DUSP17, LMWDSP3, SKRP1, TS-DSP1, dual specificity protein phosphatase 19, SAPK pathway-regulating phosphatase 1, dual specificity phosphatase TS-DSP1, low molecular weight dual specificity phosphatase 3, protein phosphatase SKRP1, stress-activated protein kinase pathway-regulating phosphatase 1
Species: human
Products:     DUSP19

Top Publications

  1. Bou├žanova F, Maia A, Cruz A, Millar V, Mendes Pinto I, Relvas J, et al. Collar occupancy: A new quantitative imaging tool for morphometric analysis of oligodendrocytes. J Neurosci Methods. 2018;294:122-135 pubmed publisher
    ..cells, we were able to evaluate the role of new molecules in OL differentiation and myelination, such as Dusp19 and Kank2...
  2. Zama T, Aoki R, Kamimoto T, Inoue K, Ikeda Y, Hagiwara M. A novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway. Implication for the precise regulation of the particular MAPK pathway. J Biol Chem. 2002;277:23909-18 pubmed
    ..We report the identification and characterization of a novel MKP termed SKRP1 (SAPK pathway-regulating phosphatase 1)...
  3. Zama T, Aoki R, Kamimoto T, Inoue K, Ikeda Y, Hagiwara M. Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway. J Biol Chem. 2002;277:23919-26 pubmed
    Stress-activated protein kinase (SAPK) pathway-regulating phosphatase 1 (SKRP1) has been identified as a member of the mitogen-activated protein kinase (MAPK) phosphatase (MKP) family that interacts physically with the MAPK kinase (MAPKK)..
  4. Cheng H, Gao Q, Jiang M, Ma Y, Ni X, Guo L, et al. Molecular cloning and characterization of a novel human protein phosphatase, LMW-DSP3. Int J Biochem Cell Biol. 2003;35:226-34 pubmed
    ..LMW-DSP3 showed phosphatase activity toward oligopeptides containing pSer/Thr and pTyr, indicating that LMW-DSP3 is a protein phosphatase with dual substrate specificity. ..
  5. Patterson K, Brummer T, O Brien P, Daly R. Dual-specificity phosphatases: critical regulators with diverse cellular targets. Biochem J. 2009;418:475-89 pubmed
    ..The present review provides an overview of the DUSP family before focusing on atypical DUSPs, emerging as a group of proteins with vastly diverse substrate specificity and function. ..
  6. Wang Y, Xu Z, Wang J, Xu S. DUSP19, a downstream effector of leptin, inhibits chondrocyte apoptosis via dephosphorylating JNK during osteoarthritis pathogenesis. Mol Biosyst. 2016;12:721-8 pubmed publisher
    ..b>Dual specificity protein phosphatase 19 (DUSP19), a member of mitogen-activated protein kinase (MAPK) phosphatases (MKPs), controls the ..
  7. Yao Z, Hu A, Liu X. DUSP19 regulates IL-1?-induced apoptosis and MMPs expression in rat chondrocytes through JAK2/STAT3 signaling pathway. Biomed Pharmacother. 2017;96:1209-1215 pubmed publisher
    ..To examine whether DUSP19 and inhibitor of the JAK2/STAT3 will influence the response of rat chondrocytes cultured with IL-1?...
  8. Wei C, Ryu S, Jeon Y, Yoon M, Jeong D, Kim S, et al. Crystal structure of a novel mitogen-activated protein kinase phosphatase, SKRP1. Proteins. 2011;79:3242-6 pubmed publisher
  9. St Denis N, Gupta G, Lin Z, Gonzalez Badillo B, Veri A, Knight J, et al. Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. Cell Rep. 2016;17:2488-2501 pubmed publisher
    ..Using clues from the interactome, we have uncovered unsuspected roles for DUSP19 in mitotic exit, CDC14A in regulating microtubule integrity, PTPRF in mitotic retraction fiber integrity, and ..