Gene Symbol: DUSP18
Description: dual specificity phosphatase 18
Alias: DSP18, DUSP20, LMWDSP20, dual specificity protein phosphatase 18, low molecular weight dual specificity phosphatase 20
Ryu J, Lee D. Dual-specificity phosphatase 18 modulates the SUMOylation and aggregation of Ataxin-1. Biochem Biophys Res Commun. 2018;502:389-396 pubmed publisher
..Here we show that dual-specificity phosphatase 18 (DUSP18), a member of protein tyrosine phosphatases, exerts the opposite effects on ataxin-1...
Wu Q, Huang S, Sun Y, Gu S, Lu F, Dai J, et al
. Dual specificity phosphotase 18, interacting with SAPK, dephosphorylates SAPK and inhibits SAPK/JNK signal pathway in vivo. Front Biosci. 2006;11:2714-24 pubmed
..Dual-specificity phosphatase 18 (DUSP18), a newly recognized SAPK/JNK phosphatase, is widely expressed...
Hood K, Tobin J, Yoon C. Identification and characterization of two novel low-molecular-weight dual specificity phosphatases. Biochem Biophys Res Commun. 2002;298:545-51 pubmed
..Our data suggest that these novel LMW-DSPs might belong to a new subclass of testis-specific proteins that act independently of the MAPK signal transduction cascade and do not depend on N-terminal docking regions for substrate binding. ..
Jeong D, Cho Y, Yoon T, Kim J, Son J, Ryu S, et al
. Structure of human DSP18, a member of the dual-specificity protein tyrosine phosphatase family. Acta Crystallogr D Biol Crystallogr. 2006;62:582-8 pubmed
The human dual-specificity protein phosphatase 18 (DSP18) gene and its protein product have recently been characterized. Like most DSPs, DSP18 displays dephosphorylating activity towards both phosphotyrosine and phosphothreonine residues...
Rardin M, Wiley S, Murphy A, Pagliarini D, Dixon J. Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane. J Biol Chem. 2008;283:15440-50 pubmed publisher
..Here, we identify two members of the atypical dual specificity phosphatases (DSP), DSP18 and DSP21, that are localized in mitochondria...
Wu Q, Gu S, Dai J, Dai J, Wang L, Li Y, et al
. Molecular cloning and characterization of a novel dual-specificity phosphatase18 gene from human fetal brain. Biochim Biophys Acta. 2003;1625:296-304 pubmed
..In this study, a novel human DSP gene named Dual-specificity Phosphatase18 (DUSP18) was isolated by large-scale sequencing analysis of a human fetal brain cDNA library...
Patterson K, Brummer T, O Brien P, Daly R. Dual-specificity phosphatases: critical regulators with diverse cellular targets. Biochem J. 2009;418:475-89 pubmed
..The present review provides an overview of the DUSP family before focusing on atypical DUSPs, emerging as a group of proteins with vastly diverse substrate specificity and function. ..
Jeong D, Wei C, Ku B, Jeon T, Chien P, Kim J, et al
. The family-wide structure and function of human dual-specificity protein phosphatases. Acta Crystallogr D Biol Crystallogr. 2014;70:421-35 pubmed publisher
..The family-wide structures of DUSPs form a basis for the understanding of phosphorylation-mediated signal transduction and the development of therapeutics. ..