Genomes and Genes
Gene Symbol: DUSP13
Description: dual specificity phosphatase 13
Alias: BEDP, DUSP13A, DUSP13B, MDSP, SKRP4, TMDP, dual specificity protein phosphatase 13, branching-enzyme interacting DSP, branching-enzyme interacting dual-specificity protein phosphatase, muscle-restricted DSP, testis- and skeletal-muscle-specific DSP
- Kim S, Jeong D, Yoon T, Son J, Cho S, Ryu S, et al. Crystal structure of human TMDP, a testis-specific dual specificity protein phosphatase: implications for substrate specificity. Proteins. 2007;66:239-45 pubmedThe testis- and skeletal-muscle-specific dual-specificity phosphatase (TMDP) is a member of the dual-specificity phosphatase (DSP) subgroup of protein tyrosine phosphatases...
- Katagiri C, Masuda K, Nomura M, Tanoue K, Fujita S, Yamashita Y, et al. DUSP13B/TMDP inhibits stress-activated MAPKs and suppresses AP-1-dependent gene expression. Mol Cell Biochem. 2011;352:155-62 pubmed publisherThe dual-specificity phosphatase (DUSP) 13 gene encodes two atypical DUSPs, DUSP13B/TMDP and DUSP13A/MDSP using alternative exons...
- Jeong D, Wei C, Ku B, Jeon T, Chien P, Kim J, et al. The family-wide structure and function of human dual-specificity protein phosphatases. Acta Crystallogr D Biol Crystallogr. 2014;70:421-35 pubmed publisher..The family-wide structures of DUSPs form a basis for the understanding of phosphorylation-mediated signal transduction and the development of therapeutics. ..
- Wei C, Min H, Kim M, Kim G, Chun H, Ryu S. Two intermediate states of the conformational switch in dual specificity phosphatase 13a. Pharmacol Res. 2018;128:211-219 pubmed publisher..Here, we determined the crystal structure of DUSP13a, and identified two different structures that represent intermediates of the postulated conformational switch...