DUSP13

Summary

Gene Symbol: DUSP13
Description: dual specificity phosphatase 13
Alias: BEDP, DUSP13A, DUSP13B, MDSP, SKRP4, TMDP, dual specificity protein phosphatase 13, branching-enzyme interacting DSP, branching-enzyme interacting dual-specificity protein phosphatase, muscle-restricted DSP, testis- and skeletal-muscle-specific DSP
Species: human
Products:     DUSP13

Top Publications

  1. Fridley B, Armasu S, Cicek M, Larson M, Wang C, Winham S, et al. Methylation of leukocyte DNA and ovarian cancer: relationships with disease status and outcome. BMC Med Genomics. 2014;7:21 pubmed publisher
    ..The top association was observed for the methylation probe cg04834572 located approximately 315 kb upstream of DUSP13 (p = 1.6 x10-14). Other disease-associated CpGs included those near or within HHIP (cg14580567; p =5...
  2. Tang Q, Cheng Z, Yang N, Li Q, Wang P, Chen D, et al. Hydrangea-structured tumor microenvironment responsive degradable nanoplatform for hypoxic tumor multimodal imaging and therapy. Biomaterials. 2019;205:1-10 pubmed publisher
    ..MnO2 nanoparticles, and a tumor microenvironment (TME) responsive degradable nanoplatform (MDSP NP) is established...
  3. Dallaston K, Rumbach A. Vocal Performance of Group Fitness Instructors Before and After Instruction: Changes in Acoustic Measures and Self-Ratings. J Voice. 2016;30:127.e1-8 pubmed publisher
    ..intensity (volume), jitter, shimmer, harmonic-to-noise ratio (HNR), maximum duration of sustained phonation (MDSP), and pitch range. Additionally, self-ratings of voice quality were obtained before and after instruction...
  4. Bahrami Z, Badiei A, Atyabi F, Darabi H, Mehravi B. Piperazine and its carboxylic acid derivatives-functionalized mesoporous silica as nanocarriers for gemcitabine: adsorption and release study. Mater Sci Eng C Mater Biol Appl. 2015;49:66-74 pubmed publisher
    ..SBA-15 nanorods were synthesized by post grafting method with methyldimethoxysilylpropylpiperazine (MDSP)...
  5. Pavic K, Duan G, Köhn M. VHR/DUSP3 phosphatase: structure, function and regulation. FEBS J. 2015;282:1871-90 pubmed publisher
    ..We give a detailed overview of VHR/DUSP3 phosphatase and compare it with its most closely related phosphatases DUSP13B, DUSP26 and DUSP27.
  6. Lei T, Wang H, Li F, Cui Y, Fu F, Li R, et al. De Novo 1.77-Mb Microdeletion of 10q22.2q22.3 in a Girl With Developmental Delay, Speech Delay, Congenital Cleft Palate, and Bilateral Hearing Impairment. Cleft Palate Craniofac J. 2017;54:343-350 pubmed publisher
    ..77-Mb de novo interstitial deletion in 10q22.2q22.3. The deletion harbors 9 genes, including KAT6B, DUPD1, DUSP13, SAMD8, VDAC2, COMTD1, ZNF503, NCRNA00245, and C10orf11...
  7. Bagshaw A, Horwood L, Fergusson D, Gemmell N, Kennedy M. Microsatellite polymorphisms associated with human behavioural and psychological phenotypes including a gene-environment interaction. BMC Med Genet. 2017;18:12 pubmed publisher
    ..Our results suggest that it participates in a gene-environment interaction with MDSP and antisocial behaviour...
  8. Nakamura K, Shima H, Watanabe M, Haneji T, Kikuchi K. Molecular cloning and characterization of a novel dual-specificity protein phosphatase possibly involved in spermatogenesis. Biochem J. 1999;344 Pt 3:819-25 pubmed
    ..In the present study, we identified a novel DSP, termed TMDP (testis- and skeletal-muscle-specific DSP)...
  9. Chen H, Luche R, Wei B, Tonks N. Characterization of two distinct dual specificity phosphatases encoded in alternative open reading frames of a single gene located on human chromosome 10q22.2. J Biol Chem. 2004;279:41404-13 pubmed
    ..two distinct DSPs: the previously described testis and skeletal muscle-specific dual specificity phosphatase (TMDP) and a novel DSP, muscle-restricted dual specificity phosphatase (MDSP)...

More Information

Publications13

  1. Kim S, Jeong D, Yoon T, Son J, Cho S, Ryu S, et al. Crystal structure of human TMDP, a testis-specific dual specificity protein phosphatase: implications for substrate specificity. Proteins. 2007;66:239-45 pubmed
    The testis- and skeletal-muscle-specific dual-specificity phosphatase (TMDP) is a member of the dual-specificity phosphatase (DSP) subgroup of protein tyrosine phosphatases...
  2. Katagiri C, Masuda K, Nomura M, Tanoue K, Fujita S, Yamashita Y, et al. DUSP13B/TMDP inhibits stress-activated MAPKs and suppresses AP-1-dependent gene expression. Mol Cell Biochem. 2011;352:155-62 pubmed publisher
    The dual-specificity phosphatase (DUSP) 13 gene encodes two atypical DUSPs, DUSP13B/TMDP and DUSP13A/MDSP using alternative exons...
  3. Jeong D, Wei C, Ku B, Jeon T, Chien P, Kim J, et al. The family-wide structure and function of human dual-specificity protein phosphatases. Acta Crystallogr D Biol Crystallogr. 2014;70:421-35 pubmed publisher
    ..The family-wide structures of DUSPs form a basis for the understanding of phosphorylation-mediated signal transduction and the development of therapeutics. ..
  4. Wei C, Min H, Kim M, Kim G, Chun H, Ryu S. Two intermediate states of the conformational switch in dual specificity phosphatase 13a. Pharmacol Res. 2018;128:211-219 pubmed publisher
    ..Here, we determined the crystal structure of DUSP13a, and identified two different structures that represent intermediates of the postulated conformational switch...