DUSP10

Summary

Gene Symbol: DUSP10
Description: dual specificity phosphatase 10
Alias: MKP-5, MKP5, dual specificity protein phosphatase 10, dual specificity phosphatase MKP-5, map kinase phosphatase 5, mitogen-activated protein kinase phosphatase 5, serine/threonine specific protein phosphatase
Species: human
Products:     DUSP10

Top Publications

  1. Theodosiou A, Smith A, Gillieron C, Arkinstall S, Ashworth A. MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases. Oncogene. 1999;18:6981-8 pubmed
    ..Here we describe the characterization of a novel member of the MKP family, MKP5. The MKP5 gene, which maps to human chromosome 1q32, is expressed tissue-specifically as two transcripts of ..
  2. Houlston R, Cheadle J, Dobbins S, Tenesa A, Jones A, Howarth K, et al. Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33. Nat Genet. 2010;42:973-7 pubmed publisher
    ..02 × 10??) and 20q13.33 (rs4925386, OR = 0.93, P = 1.89 × 10?¹?). In addition to identifying new CRC risk loci, this analysis provides evidence that additional CRC-associated variants of similar effect size remain to be discovered. ..
  3. Flem Karlsen K, Tekle C, Øyjord T, Flørenes V, Mælandsmo G, Fodstad Ø, et al. p38 MAPK activation through B7-H3-mediated DUSP10 repression promotes chemoresistance. Sci Rep. 2019;9:5839 pubmed publisher
    ..in B7-H3 knockdown cells we observed an increase in the expression of dual-specific MAP kinase phosphatase (MKP) DUSP10, a MKP known to dephosphorylate and inactivate p38 MAPK...
  4. Okuno H, Okuzono H, Hayase A, Kumagai F, Tanii S, Hino N, et al. Lipin-1 is a novel substrate of protein phosphatase PGAM5. Biochem Biophys Res Commun. 2019;509:886-891 pubmed publisher
    ..Our findings further elucidate the molecular mechanisms that regulate Lipin-1. ..
  5. Rezaei N, Talebi F, Ghorbani S, Rezaei A, Esmaeili A, Noorbakhsh F, et al. MicroRNA-92a Drives Th1 Responses in the Experimental Autoimmune Encephalomyelitis. Inflammation. 2019;42:235-245 pubmed publisher
    ..Enhanced miR-92a expression was accompanied by reduced expression TSC1 or DUSP10, predicted miR-92a targets, in EAE spinal cords...
  6. Manley G, Stokes C, Marsh E, Sabroe I, Parker L. DUSP10 Negatively Regulates the Inflammatory Response to Rhinovirus through Interleukin-1β Signaling. J Virol. 2019;93: pubmed publisher
    ..in innate immunity (DUSPs 1, 4, and 10) were expressed in primary bronchial epithelial cells, and one of them, DUSP10, was downregulated by RV infection...
  7. Yamamoto T, Endo Y, Onodera A, Hirahara K, Asou H, Nakajima T, et al. DUSP10 constrains innate IL-33-mediated cytokine production in ST2hi memory-type pathogenic Th2 cells. Nat Commun. 2018;9:4231 pubmed publisher
    ..Here we show that a MAPK phosphatase Dusp10 is a key negative regulator of IL-33-induced cytokine production in Th2 cells...
  8. Liu W, Zhang L, Xu H, Li Y, Hu C, Yang J, et al. The Anti-Inflammatory Effects of Vitamin D in Tumorigenesis. Int J Mol Sci. 2018;19: pubmed publisher
    ..D influences inflammatory processes involved in cancer progression, including cytokines, prostaglandins, MAP kinase phosphatase 5 (MKP5), the nuclear factor kappa B (NF-κB) pathway, and immune cells...
  9. Yang X, Zhang H, Shang J, Liu G, Xia T, Zhao C, et al. Comparative analysis of the blood transcriptomes between wolves and dogs. Anim Genet. 2018;49:291-302 pubmed publisher
    ..Six differentially expressed genes related to the innate immune response (CCL23, TRIM10, DUSP10, RAB27A, CLEC5A and GCH1) were found in the wolf by a Gene Ontology enrichment analysis...

More Information

Publications62

  1. Benavides Serrato A, Anderson L, Holmes B, Cloninger C, Artinian N, Bashir T, et al. mTORC2 modulates feedback regulation of p38 MAPK activity via DUSP10/MKP5 to confer differential responses to PP242 in glioblastoma. Genes Cancer. 2014;5:393-406 pubmed
    ..Here we report that mTORC2 function leads to stabilization of the p38 MAPK phosphatase, DUSP10, thereby inhibiting p38 activity...
  2. Saksa N, Neme A, Ryynänen J, Uusitupa M, de Mello V, Voutilainen S, et al. Dissecting high from low responders in a vitamin D3 intervention study. J Steroid Biochem Mol Biol. 2015;148:275-82 pubmed publisher
    ..In hematopoietic cells, the genes ASAP2, CAMP, CD14, CD97, DUSP10, G0S2, IL8, LRRC8A, NINJ1, NRIP1, SLC37A2 and THBD are known as primary vitamin D targets...
  3. Zhang Z, Xiao Q, Zhang Q, Sun H, Chen J, Li Z, et al. Genomic analysis reveals genes affecting distinct phenotypes among different Chinese and western pig breeds. Sci Rep. 2018;8:13352 pubmed publisher
    ..pigs and western pigs along the first principal component, the growth gene IGF1R; the immune genes IL1R1, IL1RL1, DUSP10, RAC3 and SWAP70; the meat quality-related gene SNORA50 and the olfactory gene OR1F1 were identified as candidate ..
  4. James S, Jiao H, Teh H, Takahashi H, Png C, Phoon M, et al. MAPK Phosphatase 5 Expression Induced by Influenza and Other RNA Virus Infection Negatively Regulates IRF3 Activation and Type I Interferon Response. Cell Rep. 2015;10:1722-1734 pubmed publisher
    ..Here, we show that virus infection induces the expression of MAPK phosphatase 5 (MKP5), a dual-specificity phosphatase (DUSP), in host cells...
  5. Sanchez Contreras M, Kouri N, Cook C, Serie D, Heckman M, Finch N, et al. Replication of progressive supranuclear palsy genome-wide association study identifies SLCO1A2 and DUSP10 as new susceptibility loci. Mol Neurodegener. 2018;13:37 pubmed publisher
    ..at MAPT, MOBP, EIF2AK3 and STX6 with risk of PSP, and uncover novel associations with SLCO1A2 (rs11568563) and DUSP10 (rs6687758) variants, both of which were classified as non-significant in the original GWAS...
  6. Hömmö T, Pesu M, Moilanen E, Korhonen R. Regulation of Inflammatory Cytokine Production by MKP-5 in Macrophages. Basic Clin Pharmacol Toxicol. 2015;117:96-104 pubmed publisher
  7. Pahl M, Erdman R, Kuivaniemi H, Lillvis J, Elmore J, Tromp G. Transcriptional (ChIP-Chip) Analysis of ELF1, ETS2, RUNX1 and STAT5 in Human Abdominal Aortic Aneurysm. Int J Mol Sci. 2015;16:11229-58 pubmed publisher
    ..00 × 10-04). Quantitative PCR assays confirmed a sub-set of the transcription factor binding sites including those in MTMR11, DUSP10, ITGAM, MARCH1, HDAC8, MMP14, MAGI1, THBD and SPOCK1.
  8. Manzano R, Martínez Navarro E, Forteza J, Brugarolas A. Microarray phosphatome profiling of breast cancer patients unveils a complex phosphatase regulatory role of the MAPK and PI3K pathways in estrogen receptor-negative breast cancers. Int J Oncol. 2014;45:2250-66 pubmed publisher
    ..identify a selective group of phosphatases upregulated only in the ER- ERBB2+ subgroup and not in ER+ (like DUSP6, DUSP10 and PPAPDC1A among others), suggesting a role of these phosphatases in specific BC subtypes, unlike other ..
  9. Zhang Y, Nguyen T, Tang P, Kennedy N, Jiao H, Zhang M, et al. Regulation of Adipose Tissue Inflammation and Insulin Resistance by MAPK Phosphatase 5. J Biol Chem. 2015;290:14875-83 pubmed publisher
    ..In this study, we show that mice deficient in MAPK phosphatase 5 (MKP5) develop insulin resistance spontaneously at an early stage of life and glucose intolerance at a later age...
  10. Wang C, He B, Piao D, Han P. Roux-en-Y Esophagojejunostomy Ameliorates Renal Function Through Reduction of Renal Inflammatory and Fibrotic Markers in Diabetic Nephropathy. Obes Surg. 2016;26:1402-13 pubmed publisher
    ..protein (MCP)-1, transforming growth factor (TGF)-β1, and mitogen-activated protein kinase phosphatase 5 (MKP5) were evaluated by real-time PCR and/or Western blotting/immunohistochemistry...
  11. McCartney D, Walker R, Morris S, Anderson S, Duff B, Marioni R, et al. Altered DNA methylation associated with a translocation linked to major mental illness. NPJ Schizophr. 2018;4:5 pubmed publisher
    ..Two of the five genes harbouring significant DMPs, DISC1 and DUSP10, have been previously shown to be differentially methylated in schizophrenia...
  12. Udhane S, Pandey A, Hofer G, Mullis P, Flück C. Retinoic acid receptor beta and angiopoietin-like protein 1 are involved in the regulation of human androgen biosynthesis. Sci Rep. 2015;5:10132 pubmed publisher
    ..CYP21A2, RARB, ASS1, CFI, ASCL1 and ENC1 play a role in steroid and energy metabolism and ANGPTL1, PLK2, DUSP6, DUSP10 and FREM2 are involved in signal transduction...
  13. Johnson M, Reeder J, O CONNELL M. p38MAPK activation and DUSP10 expression in meningiomas. J Clin Neurosci. 2016;30:110-114 pubmed publisher
    ..b>DUSP10 is also a likely participant in regulating meningioma proliferation...
  14. Frigolet M, Thomas G, Beard K, Lu H, Liu L, Fantus I. The bradykinin-cGMP-PKG pathway augments insulin sensitivity via upregulation of MAPK phosphatase-5 and inhibition of JNK. Am J Physiol Endocrinol Metab. 2017;313:E321-E334 pubmed publisher
    ..These data indicate that BK enhances insulin action by inhibition of negative feedback by JNK and ERK via upregulation of MKP-5, mediated by the sGC-cGMP-PKG signaling pathway. ..
  15. Lee H, Min K, Yi J, Shi H, Chang W, Jackson L, et al. A Phosphoproteomic Screen Identifies a Guanine Nucleotide Exchange Factor for Rab3A Protein as a Mitogen-activated Protein (MAP) Kinase Phosphatase-5-regulated MAP Kinase Target in Interleukin 6 (IL-6) Secretion and Myogenesis. J Biol Chem. 2017;292:3581-3590 pubmed publisher
    ..These data support the notion that MKP-5 serves as a negative regulator of MAPK-dependent signaling of critical skeletal muscle signaling pathways. ..
  16. Williams M, Biguetti C, Romero Bustillos M, Maheshwari K, Dinçkan N, Cavalla F, et al. Colorectal Cancer-Associated Genes Are Associated with Tooth Agenesis and May Have a Role in Tooth Development. Sci Rep. 2018;8:2979 pubmed publisher
    ..36 × 10-10) and DUSP10 rs6687758 (P = 1.25 × 10-9), and positive association found with CASC8 rs10505477 (P = 8...
  17. Choi H, Kim W, Kim E, Han B, Min J, Chi S, et al. Dual-specificity phosphatase 10 controls brown adipocyte differentiation by modulating the phosphorylation of p38 mitogen-activated protein kinase. PLoS ONE. 2013;8:e72340 pubmed publisher
    ..Here, we investigate the potential role of dual-specificity phosphatase 10 (DUSP10) in brown adipocyte differentiation using primary brown preadipocytes...
  18. Mo S, Liu X, Hao X, Chen W, Zhang K, Cai J, et al. EYA4 functions as tumor suppressor gene and prognostic marker in pancreatic ductal adenocarcinoma through ?-catenin/ID2 pathway. Cancer Lett. 2016;380:403-12 pubmed publisher
    ..We showed that EYA4 functioned as tumor suppressor gene in PDAC via repressing ?-catenin/ID2 activation, and was an independent prognostic factor in PDAC. ..
  19. Matsui S, Ogata Y. Effects of miR-223 on expression of IL-1? and IL-6 in human gingival fibroblasts. J Oral Sci. 2016;58:101-8 pubmed publisher
    ..These findings indicate that miR-223 might control the inflammatory response via IKK? and MKP-5 in periodontal tissue. (J Oral Sci 58, 101-108, 2016). ..
  20. Ma L, Bayram Y, McLaughlin H, Cho M, Krokosky A, Turner C, et al. De novo missense variants in PPP1CB are associated with intellectual disability and congenital heart disease. Hum Genet. 2016;135:1399-1409 pubmed
    ..Our data suggest that our heterozygous de novo PPP1CB pathogenic variants are associated with syndromic intellectual disability. ..
  21. Claudio J, Liew C, Dempsey A, Cukerman E, Stewart A, Na E, et al. Identification of sequence-tagged transcripts differentially expressed within the human hematopoietic hierarchy. Genomics. 1998;50:44-52 pubmed
    ..Thus, included in the KG1a EST dataset are candidates for new human genes that may play roles in hematopoietic differentiative progression and lineage commitment. ..
  22. Taxman D, Holley Guthrie E, Huang M, Moore C, Bergstralh D, Allen I, et al. The NLR adaptor ASC/PYCARD regulates DUSP10, mitogen-activated protein kinase (MAPK), and chemokine induction independent of the inflammasome. J Biol Chem. 2011;286:19605-16 pubmed publisher
    ..phosphorylation by pathogens and Toll-like receptor agonists via suppression of the dual-specificity phosphatase, DUSP10/MKP5. Chemokine induction, DUSP function, and MAPK phosphorylation were independent of caspase-1 and IL-1?...
  23. Png C, Weerasooriya M, Guo J, James S, Poh H, Osato M, et al. DUSP10 regulates intestinal epithelial cell growth and colorectal tumorigenesis. Oncogene. 2016;35:206-17 pubmed publisher
    Dual specificity phosphatase 10 (DUSP10), also known as MAP kinase phosphatase 5 (MKP5), negatively regulates the activation of MAP kinases...
  24. Jeong D, Yoon T, Kim J, Shim M, Jung S, Son J, et al. Crystal structure of the catalytic domain of human MAP kinase phosphatase 5: structural insight into constitutively active phosphatase. J Mol Biol. 2006;360:946-55 pubmed
    b>MAP kinase phosphatase 5 (MKP5) is a member of the mitogen-activated protein kinase phosphatase (MKP) family and selectively dephosphorylates JNK and p38...
  25. Nonn L, Duong D, Peehl D. Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells. Carcinogenesis. 2007;28:1188-96 pubmed
    ..In this study, we demonstrate a role for mitogen-activated protein kinase phosphatase-5 (MKP5) in mediating anti-inflammatory activities of the phytochemicals curcumin, resveratrol and [6]-gingerol...
  26. Malinowski J, Denny J, Bielinski S, Basford M, Bradford Y, Peissig P, et al. Genetic variants associated with serum thyroid stimulating hormone (TSH) levels in European Americans and African Americans from the eMERGE Network. PLoS ONE. 2014;9:e111301 pubmed publisher
    ..These results support the previously reported association between PDE8B and serum TSH levels in European Americans and emphasize the need for additional genetic studies in more diverse populations. ..
  27. Masuda K, Shima H, Kikuchi K, Watanabe Y, Matsuda Y. Expression and comparative chromosomal mapping of MKP-5 genes DUSP10/Dusp10. Cytogenet Cell Genet. 2000;90:71-4 pubmed
    ..On the other hand, the 2.7-kb transcript was specifically and highly expressed in testis. The MKP-5 genes (DUSP10/Dusp10) were localized to chr 1q41, Chr 1H5 and chr 13q26 in human, mouse and rat, respectively...
  28. Zhang T, Li X, Du Q, Gong S, Wu M, Mao Z, et al. DUSP10 gene polymorphism and risk of colorectal cancer in the Han Chinese population. Eur J Cancer Prev. 2014;23:173-6 pubmed publisher
    ..A recent study suggests that DUSP10 is frequently upregulated in colorectal cancer (CRC)...
  29. Tanoue T, Maeda R, Adachi M, Nishida E. Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions. EMBO J. 2001;20:466-79 pubmed
  30. Lin H, Su S, Lin W, Lin A, Yang Y, Lii C, et al. Andrographolide inhibits hypoxia-induced hypoxia-inducible factor 1? and endothelin 1 expression through the heme oxygenase 1/CO/cGMP/MKP-5 pathways in EA.hy926 cells. Environ Toxicol. 2017;: pubmed publisher
    ..The inhibition of hypoxia-induced HIF-1? and ET-1 expression by andrographolide is likely associated with HO-1/CO/cGMP/MKP-5 pathways, which is involved in inhibiting hypoxia-induced p38 MAPK activation...
  31. Kadoya T, Khurana A, Tcherpakov M, Bromberg K, Didier C, Broday L, et al. JAMP, a Jun N-terminal kinase 1 (JNK1)-associated membrane protein, regulates duration of JNK activity. Mol Cell Biol. 2005;25:8619-30 pubmed publisher
    ..Through its regulation of JNK1 activity, JAMP emerges as a membrane-anchored regulator of the duration of JNK1 activity in response to diverse stress stimuli...
  32. Furuta J, Ariyoshi W, Okinaga T, Takeuchi J, Mitsugi S, Tominaga K, et al. High molecular weight hyaluronic acid regulates MMP13 expression in chondrocytes via DUSP10/MKP5. J Orthop Res. 2017;35:331-339 pubmed publisher
    ..molecular mechanisms of HA in MMP13 regulation, the expression level of dual-specificity protein phosphatase 10 (DUSP10)/mitogen-activated protein kinases phosphatase 5 (MKP5) in HA-treated chondrocytes was assessed by real-time RT-..
  33. Mishra A, Oulès B, Pisco A, Ly T, Liakath Ali K, Walko G, et al. A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis. elife. 2017;6: pubmed publisher
    ..Conversely, DUSP10 expression antagonises commitment...
  34. Martell K, Angelotti T, Ullrich A. The "VH1-like" dual-specificity protein tyrosine phosphatases. Mol Cells. 1998;8:2-11 pubmed
    ..Moreover, this classification scheme may hold predictive value, since some of these motifs may hold the key to new, undiscovered functional properties. ..
  35. Tephly L, Carter A. Asbestos-induced MKP-3 expression augments TNF-alpha gene expression in human monocytes. Am J Respir Cell Mol Biol. 2008;39:113-23 pubmed publisher
    ..Taken together, these data demonstrate that the p38 MAP kinase down-regulates ERK via activation of MKP-3 in human monocytes exposed to asbestos to enhance TNF-alpha gene expression. ..
  36. Jeong D, Wei C, Ku B, Jeon T, Chien P, Kim J, et al. The family-wide structure and function of human dual-specificity protein phosphatases. Acta Crystallogr D Biol Crystallogr. 2014;70:421-35 pubmed publisher
    ..The family-wide structures of DUSPs form a basis for the understanding of phosphorylation-mediated signal transduction and the development of therapeutics. ..
  37. Duan X, Gao Y, Yang H, Feng T, Jin T, Long Y, et al. Polymorphisms in the DUSP10 gene are associated with sex-specific colorectal cancer risk in a Han population. Int J Clin Exp Pathol. 2015;8:2018-25 pubmed
    ..In this study, we investigated the role of genetic polymorphisms in the dual specificity protein phosphatase 10 (DUSP10) gene especially in sex-specific...
  38. Finch A, Caunt C, Perrett R, Tsaneva Atanasova K, McArdle C. Dual specificity phosphatases 10 and 16 are positive regulators of EGF-stimulated ERK activity: indirect regulation of ERK signals by JNK/p38 selective MAPK phosphatases. Cell Signal. 2012;24:1002-11 pubmed publisher
  39. Zhang B, Jia W, Matsuda K, Kweon S, Matsuo K, Xiang Y, et al. Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. Nat Genet. 2014;46:533-42 pubmed publisher
    ..11, 10q21.1 and 10q24.2. Furthermore, we replicated 22 previously reported CRC-associated loci. Our study provides insights into the genetic basis of CRC and suggests the involvement of new biological pathways. ..
  40. Tanoue T, Moriguchi T, Nishida E. Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5. J Biol Chem. 1999;274:19949-56 pubmed
    ..These results suggest that MKP-5 is a novel type of dual specificity phosphatase specific for p38 and SAPK/JNK. ..
  41. Hrstka R, Bouchalova P, Michalová E, Matoulkova E, Muller P, Coates P, et al. AGR2 oncoprotein inhibits p38 MAPK and p53 activation through a DUSP10-mediated regulatory pathway. Mol Oncol. 2016;10:652-62 pubmed publisher
    ..that AGR2, which is overexpressed in a variety of human cancers and provides a poor prognosis, up-regulates DUSP10 which subsequently inhibits p38 MAPK and prevents p53 activation by phosphorylation...
  42. Tanoue T, Yamamoto T, Maeda R, Nishida E. A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs. J Biol Chem. 2001;276:26629-39 pubmed
    ..MKP-5 and CL100/MKP-1 also bind to p38 alpha and -beta, but not gamma or delta. Finally, we propose a tentative classification of MKPs based on the sequence characteristics of their MAPK-docking site. ..
  43. Teng C, Huang W, Meng T. Several dual specificity phosphatases coordinate to control the magnitude and duration of JNK activation in signaling response to oxidative stress. J Biol Chem. 2007;282:28395-407 pubmed
    ..to characterize the functional role of these DUSPs and found rapid and transient induction of DUSP1 and DUSP10 to be essential for determining the appropriate magnitude of JNK activation in response to oxidative stress...
  44. Min K, Lawan A, Bennett A. Loss of MKP-5 promotes myofiber survival by activating STAT3/Bcl-2 signaling during regenerative myogenesis. Skelet Muscle. 2017;7:21 pubmed publisher
    ..Finally, these results suggest that MKP-5 inhibition may serve as an important therapeutic target for the preservation of skeletal muscle survival in degenerative muscle diseases. ..
  45. Chang C, Zhang Q, Liu Z, Clynes R, Suciu Foca N, Vlad G. Downregulation of inflammatory microRNAs by Ig-like transcript 3 is essential for the differentiation of human CD8(+) T suppressor cells. J Immunol. 2012;188:3042-52 pubmed publisher
    ..In conclusion, ILT3Fc inhibits T cell activation and induces the generation of Ts targeting multiple inflammatory miRNA pathways. ..
  46. Tao X, Tong L. Crystal structure of the MAP kinase binding domain and the catalytic domain of human MKP5. Protein Sci. 2007;16:880-6 pubmed
    ..We report here the crystal structures at up to 2.2 A resolution of the BD and CD of human MKP5 and compare them to the known structures from other MKPs...
  47. Ryynänen J, Neme A, Tuomainen T, Virtanen J, Voutilainen S, Nurmi T, et al. Changes in vitamin D target gene expression in adipose tissue monitor the vitamin D response of human individuals. Mol Nutr Food Res. 2014;58:2036-45 pubmed publisher
    ..Taking the genes DUSP10, TRAK1, NRIP1, and THBD as examples, we confirmed the predicted VDR binding sites upstream of their transcription ..
  48. Bose A, Janes K. A high-throughput assay for phosphoprotein-specific phosphatase activity in cellular extracts. Mol Cell Proteomics. 2013;12:797-806 pubmed publisher
    ..Our assay platform should be beneficial for phosphoproteomic surveys and computational-systems models of signaling, where phosphatases are known to be important but their activities are rarely measured. ..
  49. Zhang Y, Wu J, Wang Z. A distinct interaction mode revealed by the crystal structure of the kinase p38? with the MAPK binding domain of the phosphatase MKP5. Sci Signal. 2011;4:ra88 pubmed publisher
    ..structure of p38? in complex with the MAPK binding domain (KBD) from MAPK phosphatase 5 (MKP5) at 2.7 Å resolution...
  50. Mills B, Albert G, Halterman M. Expression Profiling of the MAP Kinase Phosphatase Family Reveals a Role for DUSP1 in the Glioblastoma Stem Cell Niche. Cancer Microenviron. 2017;10:57-68 pubmed publisher
    ..Neoplasia DaTa (REMBRANDT) revealed induction (DUSP4, DUSP6), repression (DUSP2, DUSP7-9), or mixed (DUSP1, DUSP5, DUSP10, DUSP15) DUSP transcription of select DUSPs in bulk tumor specimens...
  51. Nomura M, Shiiba K, Katagiri C, Kasugai I, Masuda K, Sato I, et al. Novel function of MKP-5/DUSP10, a phosphatase of stress-activated kinases, on ERK-dependent gene expression, and upregulation of its gene expression in colon carcinomas. Oncol Rep. 2012;28:931-6 pubmed publisher
    Mitogen-activated protein kinase phosphatase 5 (MKP-5)/DUSP10 acts as a phosphatase of stress-activated kinases (JNK and p38), but its activity towards ERK has not been demonstrated...
  52. Song M, Park Y, Ryu J. Polycyclic aromatic hydrocarbon (PAH)-mediated upregulation of hepatic microRNA-181 family promotes cancer cell migration by targeting MAPK phosphatase-5, regulating the activation of p38 MAPK. Toxicol Appl Pharmacol. 2013;273:130-9 pubmed publisher
    ..Based on these results, we conclude that the miR-181 family plays a critical role in PAH-induced hepatocarcinogenesis by targeting MKP-5, resulting in the regulation of p38 MAPK activation. ..
  53. Ng K, Chan L, Chai S, Tong M, Guan X, Lee N, et al. TP53INP1 Downregulation Activates a p73-Dependent DUSP10/ERK Signaling Pathway to Promote Metastasis of Hepatocellular Carcinoma. Cancer Res. 2017;77:4602-4612 pubmed publisher
    ..Mechanistic investigations revealed that TP53INP1 downregulation in early-stage HCC cells promoted metastasis via DUSP10 phosphatase-mediated activation of the ERK pathway...